ribose ADP ribose ADPribosylation is the addition of one or more ADP ribose moieties to a protein ... ADPribosylation journal EMBO J. volume 22 issue 9 pages 1953 8 year 2003 pmid 12727863 doi 10.1093 emboj cdg209 pmc 156081 ref ADPribosylation enzymes One way this protein modification can be produced is by NAD diphthamide ADP ribosyltransferase NAD sup sup diphthamide ADP ribosyltransferase enzymes, which transfer the ADP ribose group from nicotinamide adenine dinucleotide NAD sup sup onto acceptors such as arginine , glutamic acid , or aspartic acid . In human s, one type of ADP ribosyltransferases is Type is subject predicate does not agree with its complement. the NAD arginine ADP ribosyltransferases, which modify amino acid residues in proteins such as histone s by adding a single ADP ... anchored, secreted, and intracellular vertebrate mono ADP ribosyltransferases journal ... ref These reactions are reversible for example, when arginine is modified, the ADP ribosylarginine produced can be removed by ADP ribosylarginine hydrolases. ref cite journal author Takada T, Okazaki IJ, Moss J title ADP ribosylarginine hydrolases journal Mol. Cell. Biochem. volume 138 issue 1 2 pages 119 22 year 1994 pmid 7898453 doi 10.1007 BF00928452 ref Multiple groups of ADP ribose ... ADP ribosyl ation. ref name Diefenbach cite journal author Diefenbach J, B rkle A title Introduction to poly ADP ribose metabolism journal Cell. Mol. Life Sci. volume 62 issue 7 8 pages 721 30 year ... ADP ribose polymerase poly ADP ribose polymerase s PARPs , which are found in most eukaryote s, but not prokaryote ... Poly ADP ribose . The most elaborate metabolite of NAD journal FEBS J. volume 272 issue 18 pages 4576 89 year 2005 pmid 16156780 doi 10.1111 j.1742 4658.2005.04864.x ref The poly ADP ribose structure ... , in processes such as DNA repair and telomere maintenance. ref name Burkle Bacterial toxins ADPribosylation is also responsible for the actions of some bacterial toxin s, such as cholera toxin , diphtheria ... more details
of the human ADPribosylation factor 1 complexed with GDP. Amor JC, Harrison DH, Kahn RA, Ringe D ... AL, Kahn RA Trends Biochem Sci 1995 20 147 150. PMID 7770914 4 . Human ADPribosylation factors. A functionally ... peptides and proteins InterPro content IPR006689 DEFAULTSORT AdpRibosylation Factor Category ... more details
ADP may refer to Organizations and companies Automatic Data Processing , global provider of integrated computing and business outsourcing A roports de Paris , airport authority for the Parisian region in France Aeropuertos del Per , airport operator for airports in northern Peru Alaska Democratic Party , the local branch of the Democratic Party in the state of Alaska California Department of Alcohol and Drug Programs , Californian agency dealing with substance abuse prevention and treatment Alpha Delta Phi , a fraternal organization on college campuses Alpha Delta Pi , a sorority organization on college campuses American Democracy Project AASCU initiative , a project of the AASCU to promote understanding of civic engagement among college students American Democracy Project 527 group in Florida Arab Democratic Party Israel , a former political party in Israel Arab Democratic Party Lebanon , a political party in Lebanon Association for the Development of Pakistan , a Boston based non profit organization Azerbaijan Democratic Party Computing Android Dev Phone , a device sold by Google for Android developers Automatic data processing online payroll software People ADP, a nickname for Alessandro Del Piero , Italian footballer AdP, a nickname for Adrian Peterson , an American football player for the Minnesota Vikings. Science and Technology Adenosine diphosphate , an important molecule resulting from the transfer of energy from ATP Ammonium dihydrogen phosphate , an optical crystal Other Andorran peseta , a former currency of Andorra ADP, the IATA airport code for SLAF Anuradhapura , an airport in Sri Lanka Actual deferral percentage, a 401 k test for highly compensated employees Austin Danger Powers, the full name of film character Austin Powers character Antidepressant ... , a method to determine the percentage of body fat Disambig de ADP eo ADP fr ADP it ADP hu ADP egy rtelm s t lap nl ADP ja ADP pt ADP sr ADP ... more details
Orphan date August 2011 Infobox protein family Symbol ADP ribosyl GH Name ADP ribosylglycohydrolase image PDB 1t5j EBI.jpg width caption crystal structure of ribosylglycohydrolase mj1187 from methanococcus jannaschii Pfam PF03747 Pfam clan InterPro IPR005502 SMART PROSITE MEROPS SCOP 1t5j TCDB OPM family OPM protein CAZy CDD In molecular biology, ADP ribosylglycohydrolase is a family of enzymes which catalysis catalyses Adenosine diphosphate ADP ribosylations. This family includes enzyme s such as ADP ribosylarginine hydrolase EC number 3.2.2.19. which Bond cleavage cleaves ADP ribose L arginine. ref name pmid8349667 cite journal author Takada T, Iida K, Moss J title Cloning and site directed mutagenesis of human ADP ribosylarginine hydrolase journal J. Biol. Chem. volume 268 issue 24 pages 17837 43 year 1993 month August pmid 8349667 doi url ref The family also includes dinitrogenase reductase activating glycohydrolase, ref name pmid2506427 cite journal author Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP title Genes coding for the reversible ADPribosylation system of dinitrogenase reductase from Rhodospirillum rubrum journal Mol. Gen. Genet. volume 218 issue 2 pages 340 7 year 1989 month August pmid 2506427 doi 10.1007 BF00331287 url ref and most surprisingly jellyfish crystallin s, ref name pmid2506427 although these protein s appear to have lost the presumed active site residue chemistry residues . References reflist InterPro content IPR005502 Category Protein families ... more details
enzyme Name ADP deaminase EC number 3.5.4.7 CAS number 9027 79 6 IUBMB EC number 3 5 4 7 GO code 0047629 image width caption In enzymology , an ADP deaminase EC number 3.5.4.7 is an enzyme that catalysis catalyzes the chemical reaction ADP H sub 2 sub O math rightleftharpoons math IDP NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and water H sub 2 sub O , whereas its two product chemistry products are IDP and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is ADP aminohydrolase . Other names in common use include adenosine diphosphate deaminase , and adenosinepyrophosphate deaminase . References reflist 1 cite journal author Deutsch A and Nilsson R date 1954 title On the dephosphorylation and deamination of adenosine triphosphate by actomyosin gel journal Acta Chem. Scand. volume 8 pages 1898&ndash 1906 doi 10.3891 acta.chem.scand.08 1898 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
levels of ADP ribose in the cell can cause non enzymatic ADPribosylation. Non enzymatic ADPribosylation ... enzymatic ADPribosylation . ref name Ribeiroet.al.2001 For example, actin polymerization is inhibited by non enzymatic ADPribosylation at a Cys residue. Thus, it is believed that ADPRase functions ...enzyme Name ADP ribose diphosphatase EC number 3.6.1.13 CAS number 9024 83 3 IUBMB EC number 3 6 1 13 GO code 0047631 image width caption ADP ribose diphosphatase EC number 3.6.1.13 is an enzyme that catalysis ... ADP ribose to produce Adenosine monophosphate AMP and D ribose 5 phosphate. Enzyme hydrolysis ... in complex by the enzyme. Image ADP Ribose Diphosphatase Pocket shown for the substrate .png thumb This shows the full enzyme with ADP Ribose bound in the active site pocket. Blue and red areas on the surface ... pdb explore.do?structureId 1KHZ From PDB 1KHZ . The C terminal domain of ADP ribose diphosphatase .... ref name Gabelliet.al.2001 Gabelli, Sandra B. et al. The structure of ADP ribose pyrophosphatase reveals ... 72 2001 . ref ADP ribose hydrolases in general act as protective agents against excessive intracellular accumulation of ADP ribose, as high intracellular levels of ADP ribose can be damaging to the cell. ADP ribose diphosphatase, in particular, hydrolyzes ADP ribose into AMP and D ribose 5 phosphate ... placenta hydrolases active on free ADP ribose an ADP sugar pyrophosphatase and a specific ADP ribose pyrophosphatase. Biochimica et Biophysica Acta 1526 86 94 2001 . ref Other common names for ADP ribose diphosphatase include ADP ribose pyrophosphatase and ADPRase. ADP ribose is commonly referred to as ADPR. Structure Image How ADP ribose is Held in Complex by H bonds and Mg2 coordination.jpg thumb This shows how H bonds and Mg sup 2 sup coordinate and hold the AMPCPR substrate an analog of ADP ... with the attachment and coordination of H sub 2 sub O, Mg sup 2 sup , and the ADP ribose substrate. ref name Gabelliet.al.2001 Image ADP Ribose Diphosphatase Mechanism Glutamate 162 as catalyst .png ... more details
enzyme Name NAD diphthamide ADP ribosyltransferase EC number 2.4.2.36 CAS number 52933 21 8 IUBMB EC number 2 4 2 36 GO code 0047286 image width caption In enzymology , a NAD diphthamide ADP ribosyltransferase EC number 2.4.2.36 is an enzyme that catalysis catalyzes the chemical reaction NAD sup sup peptide diphthamide math rightleftharpoons math nicotinamide peptide N ADP D ribosyl diphthamide Thus, the two substrate biochemistry substrates of this enzyme are nicotinamide adenine dinucleotide NAD sup sup and peptide diphthamide , whereas its two product chemistry products are nicotinamide and peptide N ADP D ribosyl diphthamide . This enzyme belongs to the family of glycosyltransferase s, to be specific, the pentosyltransferases. The systematic name of this enzyme class is NAD peptide diphthamide N ADP D ribosyl transferase . Other names in common use include ADP ribosyltransferase , mono ADPribosyl transferase , and NAD diphthamide ADP ribosyltransferase . Structural studies As of late 2007, 15 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1S5B , PDB link 1S5C , PDB link 1S5D , PDB link 1S5E , PDB link 1S5F , PDB link 1SGK , PDB link 1TOX , PDB link 1XDT , PDB link 1XK9 , PDB link 1ZM3 , PDB link 1ZM4 , PDB link 1ZM9 , PDB link 2A5D , PDB link 2A5F , and PDB link 2A5G . References reflist 1 cite journal author Lee H, Iglewski WJ date 1984 title Cellular ADP ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A journal Proc. Natl. Acad. Sci. U. S. A. volume 81 pages 2703&ndash 7 pmid 6326138 doi 10.1073 pnas.81.9.2703 issue 9 pmc 345138 cite journal author Ueda K, Hayaishi O date 1985 title ADPribosylation journal Annu. Rev. Biochem. volume 54 issue 1 pages 73&ndash 100 pmid 3927821 doi 10.1146 annurev.bi.54.070185.000445 See also Diphtheria toxin enzyme stub Glycosyltransferases Category EC 2.4.2 Category NADH dependent enzymes Category Enzymes ... more details
enzyme Name ADP ribosyl dinitrogen reductase hydrolase EC number 3.2.2.24 CAS number 125626 63 3 IUBMB EC number 3 2 2 24 GO code 0047407 image width caption In enzymology , an ADP ribosyl dinitrogen reductase hydrolase EC number 3.2.2.24 is an enzyme that catalysis catalyzes the chemical reaction ADP D ribosyl dinitrogen reductase math rightleftharpoons math ADP D ribose dinitrogen reductase Hence, this enzyme has one substrate biochemistry substrate , ADP D ribosyl dinitrogen reductase , and two product chemistry products , ADP D ribose and dinitrogen reductase . This enzyme belongs to the family of hydrolase s, specifically those glycosylases that hydrolyse N glycosyl compounds. The systematic name of this enzyme class is ADP D ribosyl dinitrogen reductase ADP ribosylhydrolase . Other names in common use include azoferredoxin glycosidase , azoferredoxin activating enzymes , dinitrogenase reductase activating glycohydrolase , and ADP ribosyl glycohydrolase . References reflist 1 cite journal author Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP date 1989 title Genes coding for the reversible ADPribosylation system of dinitrogenase reductase from Rhodospirillum rubrum journal Mol. Gen. Genet. volume 218 pages 340&ndash 7 pmid 2506427 doi 10.1007 BF00331287 issue 2 hydrolase stub Category EC 3.2.2 Category Enzymes of unknown structure ... more details
unreferenced date March 2011 The ADP National Employment Report also popularly known as the ADP Jobs Report or ADP Employment Report is Sponsor commercial sponsor ed by Automatic Data Processing ADP , and was developed and presently maintained by Macroeconomic Advisers, LLC . The report is a measure of non farm private sector employment which measurement is obtained by utilizing an anonymous subset of roughly 500,000 United States U.S. business es which are clients of ADP. During the twelve month period through, this subset averaged over U.S. business clients and over U.S. employees working in all private industrial sectors. Category Reports on finance and business ... more details
enzyme Name ADP sugar diphosphatase EC number 3.6.1.21 CAS number 37289 32 0 IUBMB EC number 3 6 1 21 GO code 0019144 image width caption In enzymology , an ADP sugar diphosphatase EC number 3.6.1.21 is an enzyme that catalysis catalyzes the chemical reaction ADP sugar H sub 2 sub O math rightleftharpoons math AMP alpha D aldose 1 phosphate Thus, the two substrate biochemistry substrates of this enzyme are ADP sugar and water H sub 2 sub O , whereas its two product chemistry products are adenosine monophosphate AMP and alpha D aldose 1 phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is ADP sugar sugarphosphohydrolase . Other names in common use include ADP sugar pyrophosphatase , and adenosine diphosphosugar pyrophosphatase . This enzyme participates in 3 metabolism metabolic pathways fructose and mannose metabolism , purine metabolism , and starch and sucrose metabolism . References reflist 1 cite journal author Rodriguez P, Bass ST, Hansen RG date 1968 title A pyrophosphatase from mammalian tissues specific for derivatives of ADP journal Biochim. Biophys. Acta. volume 167 pages 199&ndash 201 pmid 5686292 issue 1 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
enzyme Name ADP phosphoglycerate phosphatase EC number 3.1.3.28 CAS number 37288 12 3 IUBMB EC number 3 1 3 28 GO code 0047630 image width caption In enzymology , an ADP phosphoglycerate phosphatase EC number 3.1.3.28 is an enzyme that catalysis catalyzes the chemical reaction 3 ADP 2 phosphoglycerate H sub 2 sub O math rightleftharpoons math 3 ADP glycerate phosphate Thus, the two substrate biochemistry substrates of this enzyme are 3 ADP 2 phosphoglycerate and water H sub 2 sub O , whereas its two product chemistry products are 3 ADP glycerate and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on phosphoric ester monoester bonds. The systematic name of this enzyme class is 3 ADP 2 phosphoglycerate phosphohydrolase . This enzyme is also called adenosine diphosphate phosphoglycerate phosphatase . References reflist 1 cite journal author Zancan GT, Recondo EF and Leloir LF date 1964 title Enzymic dephosphorylation of adenosine diphosphate phosphoglyceric acid journal Biochim. Biophys. Acta volume 92 pages 125&ndash 131 pmid 14243760 hydrolase stub Category EC 3.1.3 Category Enzymes of unknown structure ... more details
enzyme Name ADP thymidine kinase EC number 2.7.1.118 CAS number 82114 39 4 IUBMB EC number 2 7 1 118 GO code 0047628 image width caption In enzymology , an ADP thymidine kinase EC number 2.7.1.118 is an enzyme that catalysis catalyzes the chemical reaction ADP thymidine math rightleftharpoons math AMP thymidine 5 phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and thymidine , whereas its two product chemistry products are adenosine monophosphate AMP and thymidine 5 phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ADP thymidine 5 phosphotransferase . Other names in common use include ADP dThd phosphotransferase , and adenosine diphosphate thymidine phosphotransferase . References reflist 1 cite journal author Falke D, Labenz J, Brauer D, Muller WE date 1982 title Adenosine diphosphate thymidine 5 phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus induced deoxypyrimidine kinase journal Biochim. Biophys. Acta. volume 708 pages 99&ndash 103 pmid 6293576 issue 1 enzyme stub Kinases Category EC 2.7.1 Category Enzymes of unknown structure ... more details
enzyme Name NAD dinitrogen reductase ADP D ribosyltransferase EC number 2.4.2.37 CAS number 117590 45 1 IUBMB EC number 2 4 2 37 GO code 0030701 image width caption In enzymology , a NAD dinitrogen reductase ADP D ribosyltransferase EC number 2.4.2.37 is an enzyme that catalysis catalyzes the chemical reaction NAD sup sup dinitrogen reductase math rightleftharpoons math nicotinamide ADP D ribosyl dinitrogen reductase Thus, the two substrate biochemistry substrates of this enzyme are nicotinamide adenine dinucleotide NAD sup sup and dinitrogen reductase , whereas its two product chemistry products are nicotinamide and ADP D ribosyl dinitrogen reductase ADP D ribosyl dinitrogen reductase . This enzyme belongs to the family of glycosyltransferase s, specifically the pentosyltransferases. The systematic name of this enzyme class is NAD dinitrogen reductase ADP D ribosyl transferase . Other names in common use include NAD azoferredoxin ADPribose transferase , and NAD dinitrogen reductase ADP D ribosyltransferase . References reflist 1 cite journal author Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP date 1989 title Genes coding for the reversible ADPribosylation system of dinitrogenase reductase from Rhodospirillum rubrum journal Mol. Gen. Genet. volume 218 pages 340&ndash 7 pmid 2506427 doi 10.1007 BF00331287 issue 2 cite journal author Lowery RG, Ludden PW date 1988 title Purification and properties of dinitrogenase reductase ADP ribosyltransferase from the photosynthetic bacterium Rhodospirillum rubrum journal J. Biol. Chem. volume 263 pages 16714&ndash 9 pmid 3141411 issue 32 enzyme stub Category EC 2.4.2 Category NADH dependent enzymes Category Enzymes of unknown structure ... more details
Orphan date August 2011 File ATP ADP Translocase Top View.png thumb A cytoplasmic view of the binding pocket of ATP ADP translocase. From PDB 1OKC ATP ADP translocase is a Membrane transport protein transporter protein that enables Adenosine triphosphate ATP and Adenosine diphosphate ADP to traverse ... matrix to the cytoplasm , whereas ADP is transported from the cytoplasm to the mitochondrial ... 10 of the protein in the inner mitochondrial membrane consists of ATP ADP translocase. ref cite journal ... bi00329a029 pmid 2990548 ref Structure File ATP ADP Translocase Side View w drawn over.png thumb ... to ADP, transporting it into the matrix. From PDB 1OKC ATP ADP translocase is a homodimer with each ... cloning of a cDNA for a human ADP ATP carrier which is growth regulated journal J. Biol. Chem. year ... to ATP or ADP and has a maximal diameter of 20 and a depth of 30 . ref name nature paper cite journal ... of mitochondrial ADP ATP carrier complex with carboxyatractyloside journal Nature year 2003 month November ... directed mutagenesis of the yeast mitochondrial ADP ATP translocator. Six arginines and one lysine ... jmbi.1993.1233 pmid 8487299 ref Translocase Mechanism Under normal conditions, ATP and ADP cannot cross the inner mitochondrial membrane due to their high negative charges, but ATP ADP translocase, an antiporter , couples the transport of the two molecules. The depression in ATP ADP translocase alternatively faces the matrix and the cytoplasmic sides of the membrane. ADP binding from the cytoplasm induces eversion of the transporter and results in the release of ADP into the matrix. Binding ... brings the translocase back to its original conformation. ref name Berg ATP and ADP are the only ... is denoted by ADP sup 3 sup sub cytoplasm sub ATP sup 4 sup sub matrix sub ADP sup 3 sup sub matrix sub ATP sup 4 sup sub cytoplasm sub ATP ADP exchange is energetically expensive about 25 of the energy ... , is consumed to regenerate the membrane potential that is tapped by ATP ADP translocase. ref name Berg ... more details
enzyme Name ADP specific phosphofructokinase EC number 2.7.1.146 CAS number 237739 62 7 IUBMB EC number 2 7 1 146 GO code 0043844 image width caption In enzymology , an ADP specific phosphofructokinase EC number 2.7.1.146 is an enzyme that catalysis catalyzes the chemical reaction ADP D fructose 6 phosphate math rightleftharpoons math AMP D fructose 1,6 bisphosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and D fructose 6 phosphate , whereas its two product chemistry products are adenosine monophosphate AMP and D fructose 1,6 bisphosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ADP D fructose 6 phosphate 1 phosphotransferase . This enzyme is also called ADP 6 phosphofructokinase, ADP dependent phosphofructokinase . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1U2X . References reflist 1 cite journal author WM date 1999 title Molecular and biochemical characterization of the ADP dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus journal J. Biol. Chem. volume 274 pages 21023&ndash 8 pmid 10409652 doi 10.1074 jbc.274.30.21023 last2 Verhees first2 CH last3 Van Der Oost first3 J last4 Kengen first4 SW last5 Stams first5 AJ last6 De Vos first6 WM issue 30 enzyme stub Category EC 2.7.1 Category Enzymes of known structure ... more details
enzyme Name sulfate adenylyltransferase ADP EC number 2.7.7.5 CAS number 9027 70 7 IUBMB EC number 2 7 7 5 GO code 0004780 image width caption In enzymology , a sulfate adenylyltransferase ADP EC number 2.7.7.5 is an enzyme that catalysis catalyzes the chemical reaction ADP sulfate math rightleftharpoons math phosphate adenylyl sulfate Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and sulfate , whereas its two product chemistry products are phosphate and adenylyl sulfate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is ADP sulfate adenylyltransferase . Other names in common use include ADP sulfurylase , sulfate adenosine diphosphate adenylyltransferase , and adenosine diphosphate sulfurylase . This enzyme participates in sulfur metabolism . References reflist 1 cite journal author Grunberg Manago M, Del Campillo Campbell A, Dondon L, Michelson AM date 1966 title Yeast ADP sulfurylase catalyzing an exchange between orthophosphate and the terminal phosphate of nucleoside diphosphates journal Biochim. Biophys. Acta. volume 123 pages 1&ndash 16 pmid 5964041 issue 1 cite journal author ROBBINS PW, LIPMANN F date 1957 title Isolation and identification of active sulfate journal J. Biol. Chem. volume 229 pages 837&ndash 51 pmid 13502346 issue 2 enzyme stub Category EC 2.7.7 Category Enzymes of unknown structure ... more details
chembox verifiedrevid 424586166 ImageFile Cyclic ADP Ribose.PNG ImageSize 175px IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo 119340 53 3 PubChem 123847 IUPHAR ligand 2445 SMILES MeSHName Cyclic ADP Ribose Section2 Chembox Properties Formula C15H21N5O13P2 MolarMass 541.301 Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Cyclic ADP Ribose , frequently abbreviated as cADPR , is a cyclic adenine nucleotide like Cyclic adenosine monophosphate cAMP with two phosphate groups present on 5 OH of the adenosine like adenosine diphosphate ADP , further connected to another ribose at the 5 position, which, in turn, closes the cycle by glycosidic bond ing to the nitrogen 1 N sup 1 sup of the same adenine base whose position N sup 9 sup has the glycosidic bond to the other ribose ref cite journal author Lee ... D title The crystal structure of cyclic ADP ribose journal Nat. Struct. Biol. volume 1 issue 3 pages ... is what distinguishes cADPR from ADP ribose ADPR , the non cyclic analog. cADPR is produced from nicotinamide adenine dinucleotide NAD sup sup by ADP ribosyl cyclases List of EC numbers EC 3 EC ..., monofunctional ADP ribosyl cyclase of the mollusc Aplysia . ref cite journal author Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD title Crystal structure of Aplysia ADP ribosyl ... linkage of cyclic ADP ribose by the Mn sup 2 sup dependent ADP ribose CDP alcohol pyrophosphatase ... ref See also NAADP Inositol triphosphate IP3 ADP ribose References reflist External links ... ADP ribose. http books.google.es books?id UfUpyJZW0roC&printsec frontcover&source gbs summary r&cad 0 Cyclic ADP ribose and NAADP. The first book on these two second messengers. Calcium signaling ... fr Ad nosine diphosphate ribose cyclique gl ADP ribosa c clico nl Cyclisch ADP ribose ja ru sr Cikli na ADP riboza zh ADP ... more details
enzyme Name ADP glyceromanno heptose 6 epimerase EC number 5.1.3.20 CAS number 85030 75 7 IUBMB EC number 5 1 3 20 GO code 0008712 image width caption In enzymology , an ADP L glycero D manno heptose 6 epimerase EC number 5.1.3.20 is an enzyme that catalysis catalyzes the chemical reaction ADP D glycero D manno heptose math rightleftharpoons math ADP L glycero D manno heptose Hence, this enzyme has one substrate biochemistry substrate , ADP D glycero D manno heptose , and one product chemistry product , ADP L glycero D manno heptose . This enzyme belongs to the family of isomerase s, specifically those racemase s and epimerase s acting on carbohydrate s and derivatives. The systematic name of this enzyme class is ADP L glycero D manno heptose 6 epimerase . This enzyme participates in lipopolysaccharide biosynthesis . It employs one cofactor biochemistry cofactor , NADP in a direct oxidation mechanism. Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1EQ2 . References reflist 1 cite journal author Read JA, Ahmed RA, Morrison JP, Coleman WG Jr, Tanner ME date 2004 title The Mechanism of the Reaction Catalyzed by ADP L glycero D manno heptose 6 Epimerase journal J. Am. Chem. Soc. volume 126 pages 8878&ndash 9 pmid 15264802 doi 10.1021 ja0485659 cite journal author Ding L, Seto BL, Ahmed SA, Coleman WG Jr date 1994 title Purification and properties of the Escherichia coli K 12 NAD dependent nucleotide diphosphosugar epimerase, ADP L glycero D mannoheptose 6 epimerase journal J. Biol. Chem. volume 269 pages 24384&ndash 90 pmid 7929099 issue 39 cite journal author Raetz CR date 1990 title Biochemistry of endotoxins journal Annu. Rev. Biochem. volume 59 pages 129&ndash 70 pmid 1695830 doi 10.1146 annurev.bi.59.070190.001021 isomerase stub Category EC 5.1.3 Category NADH dependent enzymes Category Enzymes of known structure ... more details
pmid 6247348 issue 12 cite journal author Ueda K, Hayaishi O year 1985 title ADPribosylation journal ...enzyme Name NAD P protein arginine ADP ribosyltransferase EC number 2.4.2.31 CAS number 81457 93 4 IUBMB EC number 2 4 2 31 GO code 0003956 image width caption Infobox protein family Symbol ART Name ART image PDB 1gy0 EBI.jpg width caption crystal structure of the eucaryotic mono adp ribosyltransferase art2.2 crystal form c p3121 Pfam PF01129 Pfam clan CL0084 InterPro IPR000768 SMART START PROSITE PDOC00993 MEROPS SCOP 1gy0 TCDB OPM family OPM protein CAZy CDD In enzymology , a NAD P protein arginine ADP ribosyltransferase EC number 2.4.2.31 is an enzyme that catalysis catalyzes the chemical reaction using nicotinamide adenine dinucleotide NAD sup sup protein L arginine math rightleftharpoons math nicotinamide Nomega ADP D ribosyl protein L arginine NADP sup sup protein L arginine math rightleftharpoons math nicotinamide Nomega 2 phospho ADP D ribosyl protein L arginine as well as the corresponding ... math rightleftharpoons math nicotinamide Nomega ADP D ribosyl protein L arginine NADP sup sup protein L arginine math rightleftharpoons math nicotinamide Nomega 2 phospho ADP D ribosyl protein L arginine ... , whereas its two product chemistry products are nicotinamide and Nomega ADP D ribosyl protein L arginine or Nomega 2 phospho ADP D ribosyl protein L arginine, respectively . This enzyme belongs to the family ... class is NAD P protein L arginine ADP D ribosyltransferase . Other names in common use include ADP ribosyltransferase , mono ADP ribosyl transferase , NAD L arginine ADP D ribosyltransferase , NAD P arginine ADP ribosyltransferase , and NAD P L arginine ADP D ribosyltransferase . At least ... glycosylphosphatidylinositol linked ADP ribosyltransferases journal Biochemistry volume 33 issue 43 ... of a stereospecific NAD and guanidine dependent ADP ribosyltransferase from avian erythrocytes journal ..., Stanley SJ, Watkins PA year 1980 title Isolation and properties of an NAD and guanidine dependent ADP ... more details
enzyme Name ADP specific glucokinase EC number 2.7.1.147 CAS number 173585 07 4 IUBMB EC number 2 7 1 147 GO code 0043843 image width caption PBB geneid 83440 In enzymology , an ADP specific glucokinase EC number 2.7.1.147 also known as ADP dependent glucokinase is an enzyme that catalysis catalyzes the chemical reaction ADP D glucose math rightleftharpoons math AMP D glucose 6 phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and D glucose , whereas its two product chemistry products are adenosine monophosphate AMP and D glucose 6 phosphate . This enzyme belongs to the family of transferase s, to be specific those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. In humans, the ADP dependent glucokinase is encoded by the ADPGK gene . ref name pmid14975750 cite journal author Ronimus RS, Morgan HW title Cloning and biochemical characterization of a novel mouse ADP dependent glucokinase journal Biochem. Biophys. Res. Commun. volume 315 issue 3 pages 652 8 year 2004 month March pmid 14975750 doi 10.1016 j.bbrc.2004.01.103 url ref Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1GC5 . References reflist Further reading refbegin 2 cite journal author Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM year 1995 title Purification and characterization of a novel ADP dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus journal J. Biol. Chem. volume 270 pages 30453&ndash 7 pmid 8530474 doi 10.1074 jbc.270.51.30453 issue 51 cite journal author Gerhard DS title The Status, Quality, and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid ... Ronimus RS, Morgan HW title Cloning and biochemical characterization of a novel mouse ADP dependent ... more details
the synthesis of a poly ADP ribose chain PAR as a signal for the other DNA repairing enzymes such as DNA ... complementing gene 1 XRCC1 . After repairing, the PAR chains are degraded via Poly ADP ribose glycohydrolase .... journal Proteome Sci. 8 22. date 2010 04 13 ref It is interesting to note that NAD diphthamide ADP ribosyltransferase NAD is required as substrate for generating ADP ribose monomers. The overactivation ... year 2008 title Deficiency in Poly ADP ribose Polymerase 1 PARP 1 Accelerates Aging and Spontaneous ... ADP ribose polymerase 1 activity regulates JP 8 induced sustained cytokine expression in alveolar macrophages ... 17993261 pmc 2278030 ref Activity The catalytic domain is responsible for Poly ADP ribose polymerization ... Dawson first6 T. M. last7 Dawson first7 V. L. title Apoptosis inducing factor mediates poly ADP ... after attaching poly ADP ribose chains to itself after interaction with CTCF and affecting DNMT1 s enzymatic ... ADP ribose polymerase at inotekcorp.com http parplink.u strasbg.fr index.html The PARP Link Homepage at parplink.u strasbg.fr MeshName Poly ADP Ribose Polymerase http www.parp inhibitors.com Parp Inhibitors ... ADP ribosio polimerasi ru ... more details
orphan date January 2010 enzyme Name alpha 1,4 glucan protein synthase ADP forming EC number 2.4.1.113 CAS number 67053 99 0 IUBMB EC number 2 4 1 113 GO code 0047211 image width caption In enzymology , an alpha 1,4 glucan protein synthase ADP forming EC number 2.4.1.113 is an enzyme that catalysis catalyzes the chemical reaction ADP glucose protein math rightleftharpoons math ADP alpha D glucosyl protein Thus, the two substrate biochemistry substrates of this enzyme are ADP glucose and protein , whereas its two product chemistry products are adenosine diphosphate ADP and alpha D glucosyl protein . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is ADP glucose protein 4 alpha D glucosyltransferase . Other names in common use include ADP glucose protein glucosyltransferase , and adenosine diphosphoglucose protein glucosyltransferase . References reflist 1 cite journal author Barengo R, Krisman CR date 1978 title Initiation of glycogen biosynthesis in Escherichia coli. Studies of the properties of the enzymes involved journal Biochim. Biophys. Acta. volume 540 pages 190&ndash 6 pmid 418819 issue 2 Category EC 2.4.1 Category Enzymes of unknown structure enzyme stub ... more details
enzyme Name acetate CoA ligase ADP forming EC number 6.2.1.13 CAS number 62009 85 2 IUBMB EC number 6 2 1 13 GO code 0043758 image width caption In enzymology , an acetate CoA ligase ADP forming EC number 6.2.1.13 is an enzyme that catalysis catalyzes the chemical reaction ATP acetate CoA math rightleftharpoons math ADP phosphate acetyl CoA The 3 substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP , acetate , and coenzyme A CoA , whereas its 3 product chemistry products are adenosine diphosphate ADP , phosphate , and acetyl CoA . This enzyme belongs to the family of ligase s, specifically those forming carbon sulfur bonds as acid thiol ligases. The systematic name of this enzyme class is acetate CoA ligase ADP forming . Other names in common use include acetyl CoA synthetase ADP forming , acetyl coenzyme A synthetase adenosine diphosphate forming , and acetate thiokinase . This enzyme participates in pyruvate metabolism and propanoate metabolism . References reflist 1 cite journal author Reeves RE, Warren LG, Susskind B, Lo HS date 1977 title An energy conserving pyruvate to acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase journal J. Biol. Chem. volume 252 pages 726&ndash 31 pmid 13076 issue 2 ligase stub Category EC 6.2.1 Category Enzymes of unknown structure it Acetato tiochinasi ... more details
enzyme Name aspartate ammonia ligase ADP forming EC number 6.3.1.4 CAS number 37318 61 9 IUBMB EC number 6 3 1 4 GO code 0047478 image width caption In enzymology , an aspartate ammonia ligase ADP forming EC number 6.3.1.4 is an enzyme that catalysis catalyzes the chemical reaction ATP L aspartate NH sub 3 sub math rightleftharpoons math ADP phosphate L asparagine The 3 substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP , L aspartate , and ammonia NH sub 3 sub , whereas its 3 product chemistry products are adenosine diphosphate ADP , phosphate , and L asparagine . This enzyme belongs to the family of ligase s, specifically those forming carbon nitrogen bonds as acid D ammonia or amine ligases amide synthases . The systematic name of this enzyme class is L aspartate ammonia ligase ADP forming . Other names in common use include asparagine synthetase ADP forming , and asparagine synthetase adenosine diphosphate forming . This enzyme participates in nitrogen metabolism . References reflist 1 cite journal author Nair PM date 1969 title Asparagine synthetase from gamma irradiated potatoes journal Arch. Biochem. Biophys. volume 133 pages 208&ndash 15 pmid 5820987 doi 10.1016 0003 9861 69 90447 0 issue 2 ligase stub Category EC 6.3.1 Category Enzymes of unknown structure ... more details
enzyme Name succinate CoA ligase ADP forming EC number 6.2.1.5 CAS number 9080 33 5 IUBMB EC number 6 2 1 5 GO code 0004775 image 2scu.png width caption Succinyl COA synthetase from Escherichia coli . PDB PDBe 2scu ref cite pmid 9917402 ref In enzymology , a succinate CoA ligase ADP forming EC number 6.2.1.5 is an enzyme that catalysis catalyzes the chemical reaction ATP succinate CoA math rightleftharpoons math ADP phosphate succinyl CoA The 3 substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP , succinate , and coenzyme A CoA , whereas its 3 product chemistry products are adenosine diphosphate ADP , phosphate , and succinyl CoA . This enzyme belongs to the family of ligase s, specifically those forming carbon sulfur bonds as acid thiol ligases. The systematic name of this enzyme class is succinate CoA ligase ADP forming . Other names in common use include succinyl CoA synthetase ADP forming , succinic thiokinase , succinate thiokinase , succinyl CoA synthetase , succinyl coenzyme A synthetase adenosine diphosphate forming , succinyl coenzyme A synthetase , A STK adenin nucleotide linked succinate thiokinase , STK , and A SCS . This enzyme participates in 4 metabolism metabolic pathways citrate cycle tca cycle , propanoate metabolism , c5 branched dibasic acid metabolism , and reductive carboxylate cycle CO sub 2 sub fixation . Structural studies As of late 2007, 12 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1CQI , PDB link 1CQJ , PDB link 1JKJ , PDB link 1JLL , PDB link 1OI7 , PDB link 1SCU , PDB link 2NU6 , PDB link 2NU7 , PDB link 2NU8 , PDB link 2NU9 , PDB link 2NUA , and PDB link 2SCU . References reflist 1 Boyer, P.D., Lardy, H. and Myrback, K. Eds. , The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387 399. cite journal author Kaufman S date 1955 title Studies on the mechanism of the reaction catalyzed by the phosphorylating enzyme journal ... more details
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