PBB geneid 10000 RAC gamma serine threonine protein kinase is an enzyme that in humans is encoded by the AKT3 gene . ref name pmid10092583 cite journal author Brodbeck D, Cron P, Hemmings BA title A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C terminal hydrophobic domain journal J Biol Chem volume 274 issue 14 pages 9133 6 year 1999 month Apr pmid 10092583 pmc doi 10.1074 jbc.274.14.9133 ref ref name pmid10208883 cite journal author Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA title Identification of a human Akt3 protein kinase B gamma which contains the regulatory serine phosphorylation site journal Biochem Biophys Res Commun volume 257 issue 3 pages 906 10 year 1999 month Jun pmid 10208883 pmc doi 10.1006 bbrc.1999.0559 ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of the AKT serine threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet derived growth ... AKT3 v akt murine thymoma viral oncogene homolog 3 protein kinase B, gamma url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10000 accessdate ref Mice lacking Akt3 have ... in brain mass. Incidentally, Akt3 is highly expressed in the brain. Interactions AKT3 has been ... of Akt3 in estrogen receptor deficient breast cancers and androgen independent prostate cancer lines ... author Murthy SS, Tosolini A, Taguchi T, Testa JR title Mapping of AKT3, encoding a member of the Akt ... and Akt3 journal Oncogene volume 20 issue 32 pages 4419 23 year 2001 pmid 11466625 doi 10.1038 sj.onc.1204486 ... more details
AKT1 and AKT3 , whereas PHLPP1 is specific for AKT2 and AKT3. Lack of PHLPP appears to have effects ... genes in the Akt family AKT1 , AKT2 , and AKT3 . These enzyme s are members of the Protein kinase Serine.2Fthreonine ... JCI16885 url ref The role of Akt3 is less clear, though it appears to be predominantly expressed in brain. It has been reported that mice lacking Akt3 have small brains. ref name pmid16923958 cite ... Isoform of Akt Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis ... more details
Chromosome 19 Arm q Band 13.1 LocusSupplementaryData 13.2 protein Name AKT3 v akt murine thymoma viral oncogene homolog 3 protein kinase B, gamma caption image width HGNCid 393 Symbol AKT3 AltSymbols ... year 2003 month July pmid 12843127 pmc 164287 doi 10.1172 JCI16885 url ref The role of Akt3 is less ... lacking Akt3 have small brains. ref name pmid15046607 cite journal author Yang ZZ, Tschopp O, Baudry ... phosphorylate, and therefore inactivate, distinct Akt isoforms. PHLPP2 dephosphorylates Akt1 and Akt3, whereas PHLPP1 is specific for Akt 2 and Akt3. Function Akt regulates cellular survival ref name ... more details
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