Activator may mean Activator genetics , a DNA binding protein that regulates one or more genes by increasing the rate of transcription Activator proteomics , a type of effector that increases the rate of enzyme mediated reactions Activator phosphor , a type of dopant used in phosphor s and scintillator s Sega Activator , a motion sensing controller for the Sega Mega Drive Genesis Activator technique , a method of spinal adjustment disambig nl Activator nn Aktivator sv Aktivator ... more details
Unreferenced stub auto yes date December 2009 Image Fibrinolysis.png thumb 400px Fibrinolysis A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis . Types include Tissue plasminogen activator Urokinase It is inhibited by plasminogen activator inhibitor 1 and plasminogen activator inhibitor 2 . Serine endopeptidases Antithrombotics Category Hematology DEFAULTSORT Plasminogen Activator blood drug stub pt Ativador do plasminog nio ... more details
Unreferenced date December 2009 An activator is a DNA binding protein that regulates one or more gene s by increasing the rate of transcription genetics transcription . The activator may increase transcription by virtue of a connected domain which assists in the formation of the RNA polymerase holoenzyme , or may operate through a Coactivator genetics coactivator . A coactivator binds the DNA binding activator and contains the domain assisting holoenzyme formation. A particular activator may bind one or more specific coactivators. Role in transcriptional regulation RNA polymerase RNAP is usually bound to the Promoter biology promoter region on the gene which creates a complex that sometimes undergoes a transition that allows Transcription genetics transcription to take place. An activator essentially recruits the RNAP to its promoter region, by binding to the activator binding site itself which serves as a liaison between the RNA polymers and the DNA. Sometimes, the activator is required for the RNA polymerase to change DNA conformation through allostery to initiate transcription. RNAP does not spontaneously transform into the open complex and requires the activator. Examples In the lac operon of the bacteria Escherichia coli , the Lac repressor is constitutively expressed and always bound to the Operon Operator operator region of the promoter, interfering with the ability of RNAP to bind to the promoter and transcribe the lac operon. In the presence of lactose , the repressor changes conformation and falls off the operator and RNAP is able to bind to the promoter. The catabolite activator protein CAP is an example of an activator for this operon, present in prokaryotic systems. Cyclic adenosine monophosphate cAMP is present in low levels of glucose, and binds to CAP which changes to an active conformation. Only then, can CAP act as an activator and help recruit RNAP to its ... terms DEFAULTSORT Activator Genetics Category Gene expression Category Proteins de Aktivator Genetik ... more details
Refimprove date December 2007 File Activator II adjustment instrument.png thumb right Activator device The Activator Method Chiropractic Technique is a chiropractic treatment method and device created ... regarded as a low force chiropractic treatment technique . Activator Methods International ... of the Activator Method Chiropractic Technique and the associated Activator Adjusting Instruments. About Dr. Arlan Fuhr Arlan W. Fuhr, DC, co founder and chief executive officer of Activator Methods International, is the co inventor of the Activator Adjusting Instrument and the Activator Method Chiropractic Technique . The Activator Method has become the second most widely used chiropractic ... chiropractors. Today, Activator is taught in nearly every chiropractic college in the United States and abroad, and in professional seminars throughout the year. For over 45 years, Activator has remained ... the second edition of the technique textbook, The Activator Method, globally known as the standard ... in Phoenix, Arizona. About Activator Methods International More than 105 peer reviewed papers have been published on the Activator Method. Research efforts have also been funded by the National Institutes ... trained in the Activator Method is approximately 150,000 worldwide, making it the most widely ... provides online training in the Basic Scan Protocol, the cornerstone of the Activator Method, through Activator Online www.activatoronline.com . Doctors can achieve and maintain Proficiency or Advanced ... through these seminars. Physical characteristics of the activator adjusting instrument The activator ... 2005 month February title Status of Activator Methods Chiropractic Technique, Theory, and Practice journal ... j.jmpt.2005.01.001 pmid 15800504 ref Activator method chiropractic technique The activator method ... showing inter testing reliability using the Activator Method. The literature shows that properly trained ... 150,000 chiropractors worldwide have been trained to use the Activator Method. ref name ... more details
orphan date November 2009 Image SB activator front.jpg thumb Splint activator type K3F , frontal view... Image SB activator back.jpg thumb ...and back view The splint activator of Soulet Besombes is a removable appliance for the treatment of dental and jaw anomalies. It is basically a stylized activator , which is however not fitted individually, but is mass produced in various shapes and sizes. The device is also known as Position Trainer or Kaukraft Kiefer Former bite force jaw former, K3F . Design and operation The device is made from flexible material as one single piece. At its center, it is completely even and approximates the shape of an ideal dental arch. This flat part is surrounded by ramp shaped walls. The teeth of the upper and lower jaw bite into the space between these walls accordingly. Normally, there are no individual tooth slots, with the prominent exception of the Australian Myobrace design. The appliance sits passively between the upper and lower jaw, and does not exercise any force by itself to the teeth. When the patient bites together, the teeth standing out of line collide with ramp shaped walls and are moved into their correct position over time. This works due to the principle of the inclined plane and the spring force of the elastic deformation of the device. By biting more or less intensively, the patient can determine by himself how much force is applied. When the appliance is worn, the lower jaw is positioned into Angle class 1 relation towards the upper jaw. This is supposed to get the jaw muscles used to this position, and to let the patient learn the correct swallowing pattern. The teeth that in this jaw position do not reach the central plane ... today The splint activator is a rather exotic appliance, albeit in recent times, the Trainer for Kids ... patients of any age using the splint activator. External links http sodis apf.fr Societ por la distribution ... zahnklammern.de IzZ Info Basis und Initiative f r zwanglose Zahnspangen DEFAULTSORT Splint Activator ... more details
unreferenced date March 2010 In phosphor s and scintillator s, the activator is the element added as dopant to the crystal of the material to create desired type of nonhomogeneities. In luminescence , only a small fraction of atoms, called emission centers or luminescence centers , emit light. In inorganic phosphors, these inhomogeneities in the crystal structure are created usually by addition of a trace amount of dopant s, impurities called activators . In rare cases dislocation s or other crystal defect s can play the role of the impurity. The wavelength emitted by the emission center is dependent on the atom itself, its electronic configuration , and on the surrounding crystal structure. The activators prolong the emission time afterglow . In turn, other materials such as nickel can be used to quench the afterglow and shorten the decay part of the phosphor emission characteristics. The electronic configuration of the activator is depending on its oxidation state and is crucial for the light emission. Oxidation of the activator is one of the common mechanisms of phosphor degradation. The distribution of the activator in the crystal is also of high importance. Diffusion of the ions can cause depletion of the crystal from the activators with resulting loss of efficiency. This is another mechanism of phosphor degradation. The scintillation process in inorganic materials is due to the electronic band structure found in the crystal s. An incoming particle can excite an electron from the valence band to either the conduction band or the exciton band located just below the conduction band and separated from the valence band by an energy gap see picture . This leaves an associated electron hole hole behind, in the valence band. Impurities create electronic levels in the forbidden ... scintillation light fast component . In case of inorganic scintillator s, the activator impurities ... , again results in light emission slow component . The activator is the main factor determining ... more details
Image Phosphofructokinase 6PFK wpmp.png thumb right Bacillus stearothermophilus phosphofructokinase . PDB 6PFK . Enzyme activators are molecules that bind to enzyme s and increase their activity. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism . In opposition to coenzymes , enzyme activators are inorganic compound s, while both coenzyms and activators are Cofactor biochemistry cofactors . ref http www.elmhurst.edu chm vchembook 570enzymes.html ref An example of an enzyme activator working in this way is fructose 2,6 bisphosphate , which activates phosphofructokinase 1 and increases the rate of glycolysis in response to the hormone insulin . ref cite journal author Kurland IJ, Pilkis SJ title Covalent control of 6 phosphofructo 2 kinase fructose 2,6 bisphosphatase insights into autoregulation of a bifunctional enzyme url http www.proteinscience.org cgi reprint 4 6 1023 journal Protein Sci. volume 4 issue 6 pages 1023 37 year 1995 pmid 7549867 date 06 01 1995 pmc 2143155 doi 10.1002 pro.5560040601 ref ref cite journal author Okar DA, Lange AJ title Fructose 2,6 bisphosphate and control of carbohydrate metabolism in eukaryotes journal Biofactors volume 10 issue 1 pages 1 14 year 1999 pmid 10475585 doi 10.1002 biof.5520100101 ref References reflist enzyme stub Category Enzyme kinetics ca Activador enzim tic nl Activator biochemie pl Aktywator enzymatyczny pt Ativador enzim tico sr Enzimski aktivator sv Enzymaktivator zh ... more details
Orphan date February 2008 HP Service Activator HPSA is a service provisioning and activation software platform from Hewlett Packard . Once installed and integrated with a Customer Service Provider s CSP environment, HPSA automates the processes inherent in the creation and activation of new telecommunications services. It is not specific to any network or service type and can apply across fixed, mobile, or internet environments. HPSA software is activation centric, but engages the entire fulfillment stack as defined by the TeleManagement Forum s eTOM framework, including order management, resource inventory and service activation. The core of the platform is a highly scalable workflow engine that executes activation oriented workflows, and is designed to support various plug ins that control activation targets in a CSP s network and IT service infrastructure irrespective of the protocol used ... partner activation systems and other OSS BSS software. History HP Service Activator was originally ... solution from HP Software . In 2007, it transitioned to HP Service Activator under the purview .... The 5th generation product, HP Service Activator 5.0, was released in January 2008. HP Service Activator software was formerly branded HP OpenView Service Activator OVSA , but HP has since retired ... HP Service Activator Solution for VPN Services HPSA VPN Layer 2 and Layer 3 Virtual Private Network VPN services HP Service Activator Solution for Metro Ethernet HPSA ME Layer 2 Virtual Private LAN Services HP Service Activator Solution for Residential IP Services HPSA RIPS Multi play residential services delivered over an IP infrastructure HP Service Activator Solution for Managed Services HPSA MSS Managed Services for VoIP, Wireless LAN and Security Technical data HP Service Activator Software ... and XML SOAP. External links HP Service Activator and Suite of Solutions http www.hp.com go activation Category Hewlett Packard products Service Activator ... more details
Infobox protein family Symbol Activator LAG 3 Name Activator LAG 3 image PDB 2fo1 EBI.jpg width caption crystal structure of the csl notch mastermind ternary complex bound to dna Pfam PF11498 Pfam clan InterPro IPR021587 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the transcriptional activator LAG 3 is a transcription genetics transcription al Activator genetics activator protein. The Caenorhabditis elegans C. elegans Notch signaling Notch pathway, involved in the control of growth, differentiation cellular differentiation and patterning in animal development, relies on either of the receptor biochemistry receptor s GLP 1 or LIN 12. ref name pmid10830967 cite journal author Petcherski AG, Kimble J title LAG 3 is a putative transcriptional activator in the C. elegans Notch pathway journal Nature volume 405 issue 6784 pages 364 8 year 2000 month May pmid 10830967 doi 10.1038 35012645 url ref Both these Receptor biochemistry receptors promote cell signalling signalling by the recruitment of LAG 3 to target Promoter biology promoters , where it then acts as a Transcription genetics transcriptional activator. LAG 3 works as a ternary Protein complex complex together with the DNA Binding molecular binding protein, LAG 1. ref name pmid10830967 cite journal author Petcherski AG, Kimble J title LAG 3 is a putative transcriptional activator in the C. elegans Notch pathway journal Nature volume 405 issue 6784 pages 364 8 year 2000 month May pmid 10830967 doi 10.1038 35012645 url ref References reflist InterPro content IPR021587 Category Protein families ... more details
Image Lac operon.png thumb 400px Lac operon. Catabolite Activator Protein is labeled cAMP activator protein. Catabolite Activator Protein or CAP is a transcriptional activator that exists as a homodimer in solution, with each subunit comprising a Ligand biochemistry ligand binding domain at the N terminus CAP sup N sup , residues 1 138 , which is also responsible for the dimerization of the protein, and a DNA binding domain at the C terminus DBD, residues 139 209 . Two cAMP cyclic AMP molecules bind dimeric CAP with negative cooperativity and function as allosteric effectors by increasing the protein s Affinity pharmacology affinity for DNA . Cytosol ic cAMP levels rise when the amount of glucose transported into the cell is low, but lactose is readily available. CAP has a characteristic helix turn helix structure that allows it to bind to successive major groove s on DNA. The two helices are reinforcing each, causing a 43 turn in the structure, so overall causing a 94 degree turn in the DNA. ref cite pmid 1653449 ref This opens the DNA molecule up, allowing RNA polymerase to bind and Transcription genetics transcribe the genes involved in lactose catabolism . Thus, CAP enhances the expression of the lac operon when lactose is present, but not glucose. This requirement reflects the greater simplicity with which glucose may be metabolized in comparison to lactose. The cell prefers glucose, and, if it is available, the lac operon is not activated, even when lactose is present. This is an effective way of integrating the two different signals. CAP is responsible for catabolite repression , a well known example of a modulon . External links MeshName Catabolite Activator Protein References Reflist Transcription factors g0 Category DNA Cell biology stub ... more details
For the drugs cinaciguat riociguat Wikify date December 2011 A guanylate cyclase activator or GUCA is one of group of proteins which upregulates guanylate cyclase . It is also known as guanylate cyclase activating protein , with the abbreviation GCAP . Mutations can be associated with vision defects. ref name pmid9425234 cite journal author Payne AM, Downes SM, Bessant DA, et al. title A mutation in guanylate cyclase activator 1A GUCA1A in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1 journal Hum. Mol. Genet. volume 7 issue 2 pages 273 7 year 1998 pmid 9425234 doi 10.1093 hmg 7.2.273 ref There are five genes involved Gene GUCA1A , Gene GUCA1B , Gene GUCA1C Gene GUCA2A , Gene GUCA2B References references External links MeshName Guanylate Cyclase Activating Proteins Eye proteins Category Proteins biochemistry stub ... more details
PBB geneid 5055 Plasminogen activator inhibitor 2 placental PAI is a coagulation factor that inactivates Tissue plasminogen activator tPA and urokinase . It is present in most cells, especially monocytes ... internal signal peptide. Interactions Plasminogen activator inhibitor 2 SerpinB2 has been ... in immunity. Crit Rev Immunol. 2011 31 1 15 30. PMID 21395508. See also Plasminogen activator ..., Wun TC, Behrendt N, et al. title Inhibition of receptor bound urokinase by plasminogen activator inhibitors ... plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes ... BS, Monroe MC, Bradshaw JD title Endotoxin induced production of plasminogen activator inhibitor by human ... Structure of the gene for human plasminogen activator inhibitor 2. The nearest mammalian homologue of chicken ... activator inhibitors from vascular smooth muscle cells. journal Thromb. Haemost. volume ... activator inhibitor 2. Isolation and characterization of the promoter region of the gene ... in Escherichia coli of a plasminogen activator inhibitor from human placenta. journal J. Biol ... plasminogen activator inhibitor. journal Proc. Natl. Acad. Sci. U.S.A. volume 85 issue 4 pages 985 ... RL, Hession C, et al. title Plasminogen activator inhibitor 2 regulation of gene transcription ... assignment, and homology to plasminogen activator inhibitor. journal J. Exp. Med. volume 166 issue ... JL, Bates EJ, Ferrante A, Antalis TM title Plasminogen activator inhibitor type 2 inhibits tumor ... cite journal author Mikus P, Urano T, Liljestr m P, Ny T title Plasminogen activator inhibitor type ... P, et al. title Plasminogen activator inhibitor type 2 an intracellular keratinocyte differentiation ... K, Kondo H, et al. title Microglia express the type 2 plasminogen activator inhibitor in the brain ... TM title DNase I hypersensitive sites in the 5 flanking region of the human plasminogen activator ... H title Expression and localization of the urokinase type plasminogen activator receptor uPAR in the human ... more details
PBB geneid 5054 Plasminogen activator inhibitor 1 PAI 1 also known as endothelial plasminogen activator ... protease inhibitor serpin that functions as the principal inhibitor of tissue plasminogen activator ... PAI, plasminogen activator inhibitor 2 PAI 2 is secreted by the placenta and only present in significant ... activator inhibitor 1, so it accelerates the development of atherosclerosis. Pharmacology Tiplaxtinin ... 14 title Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor 1 design ... 4 author Elokdah H, Abou Gharbia M, Hennan JK, et al. ref Interactions Plasminogen activator inhibitor ... activator inhibitor type 1 and stabilizes its inhibitory activity journal J. Biol. Chem. volume ... Mimuro J title Type 1 plasminogen activator inhibitor its role in biological reactions journal ... BR title Plasminogen activator inhibitor 1 physiological and pathophysiological roles journal News Physiol ... M last7 Mihaly first7 J last8 Prager first8 GW cite journal author Eddy AA title Plasminogen activator ... of plasminogen activator inhibitor type 1 PAI 1 with vitronectin Vn mapping the binding sites ... 2004 pmid 14983217 doi 10.1160 TH03 12 0764 cite journal author Durand MK title Plasminogen activator ... Katrine E. cite journal author Harbeck N title Urokinase type plasminogen activator uPA and its ... journal author Hertig A, Rondeau E title Plasminogen activator inhibitor type 1 the two faces of the same ..., Kluft C title Plasminogen activator inhibitor type 1 its plasma determinants and relation with cardiovascular ... 10.1267 THRO04050861 cite journal author Lijnen HR title Pleiotropic functions of plasminogen activator ... activator inhibitor 1 a common denominator in obesity, diabetes and cardiovascular disease journal ... journal author Hermans PW, Hazelzet JA title Plasminogen activator inhibitor type 1 gene polymorphism ... doi 10.1086 431996 cite journal author Alessi MC, Poggi M, Juhan Vague I title Plasminogen activator ... cgi bin merops.cgi?id I04.020 I04.020 MeshName Plasminogen Activator Inhibitor 1 Coagulation Serpins ... more details
PBB geneid 5327 Tissue plasminogen activator abbreviated tPA or PLAT is a protein involved in the breakdown of blood clot s. It is a serine protease EC number 3.4.21.68 found on endothelial cell s, the cells that line the blood vessel s. As an enzyme , it catalysis catalyzes the conversion of plasminogen ... to as recombinant tissue plasminogen activator rtPA . Function Image Fibrinolysis.png left thumb ... or embolism . Tissue plasminogen activator also plays a role in cell migration and tissue remodeling . Genetics Tissue plasminogen activator is a protein encoded by the PLAT gene , which is located ... tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older journal ... plasminogen activator has been shown to Protein protein interaction interact with Fibrinogen alpha chain ... site of tissue type plasminogen activator to fibrin journal J. Clin. Invest. volume 78 issue ..., DeMaro J, Jacquin M, Bu G year 2000 month Jan. title Role of tissue plasminogen activator receptor ... plasminogen activator and its serpin inhibitor plasminogen activator inhibitor type 1 are internalized ... type plasminogen activator journal Klin. Wochenschr. volume 66 Suppl 12 issue pages 33 9 year 1988 pmid 3126346 doi cite journal author Bode W, Renatus M title Tissue type plasminogen activator ... at the lysine binding site and plasminogen activator cleavage site journal Biol. Chem. volume 383 issue ... activator and matrix metalloproteinase systems journal Mol. Cell. Endocrinol. volume 187 issue ... author Teesalu T title Tissue plasminogen activator as a key effector in neurobiology and neuropathology ...?identifier 4751 Tissue Plasminogen Activator from the American Heart Association http www.sciam.com ... DEFAULTSORT Tissue Plasminogen Activator Category Antithrombotic enzymes Category EC 3.4.21 de Gewebespezifischer ... fr Activateur tissulaire du plasminog ne id Tissue plasminogen activator nl Tissue plasminogen activator ja pl Tkankowy aktywator plazminogenu pt Ativador do plasminog nio tecidual ... more details
Continuous erythropoietin receptor activator CERA is the generic term for drugs in a new class of third generation erythropoietic stimulating agent s ESAs . In the media, these agents are commonly referred to as EPO , short for erythropoietin . CERAs have an extended half life and a mechanism of action that promotes increased stimulation of erythropoietin receptors compared with other ESAs. Under the trade name Mircera , Roche Pharmaceuticals received approval from the U.S. FDA in January 2008 to market a continuous erythropoiesis receptor activator methoxy polyethylene glycol epoetin beta for the treatment of anemia in patients with chronic kidney disease , including in those undergoing dialysis ref http www.medscape.com viewarticle 568576 FDA approval ref . Patent disputes between Amgen, which owns several patents relating to recombinant Erythropoietin EPO variants, and Roche are blocking distribution of Mircera in the U.S. Methoxy polyethylene glycol epoetin beta previously was approved by the European Commission in August 2007, and was made available in Europe at the start of 2008. citation needed date November 2011 In terms of its structure, Micera is similar to the previous synthetic EPO drugs, except that it is connected to a chemical called polyethylene glycol PEG , which makes it last longer in the body. According to Roche, the product has the longest half life of all FDA approved erythropoiesis stimulating agents ESAs up to 6 times longer than darbepoetin alfa and up to 20 times longer than epoetin. CERAs thus promise both lower dosing significant owing to the high inherent cost of manufacturing recombinant protein drugs and less frequent injections for patients. ESAs are administered via subcutaneous injections, often in doctor s offices for patients who lack the skill or dexterity to inject themselves, so the once or twice monthly dosing regimen for CERAs promises ... no Continuous erythropoietin receptor activator fi Cera ... more details
Pfam box Symbol RasGAP Name GTPase activator protein for Ras like GTPase image width caption Pfam PF00616 InterPro IPR001936 SMART RasGAP Prosite SCOP 1wer TCDB OPM family OPM protein PDB PDB3 1nf1 A 1256 1451 PDB3 1wer 769 942 PDB3 1wq1 G 769 942 GTPase activator protein for Ras like GTPase is a Protein family family of evolutionarily related proteins . Ras subfamily Ras proteins are membrane associated molecular switches that bind guanosine triphosphate GTP and guanosine diphosphate GDP and slowly hydrolyze GTP to GDP. ref name PUB00004087 cite journal author McCormick F, Bourne HR, Sanders DA title The GTPase superfamily conserved structure and molecular mechanism journal Nature volume 349 issue 6305 pages 117 127 year 1991 pmid 1898771 doi 10.1038 349117a0 ref This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as GAP or GTPase activating proteins. ref name PUB00000983 cite journal author Wang Y, Riggs M, Rodgers L, Wigler M, Boguski M title sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1 journal Cell Regul. volume 2 issue 6 pages 453 465 year 1991 pmid 1883874 ref ref name PUB00000726 cite journal author Maruta H, Burgess AW title Regulation of the Ras signalling network journal Bioessays volume 16 issue 7 pages 489 496 year 1994 pmid 7945277 doi 10.1002 bies.950160708 ref As it is the GTP bound form of ras which is active, these proteins are said to be down regulators of ras. The Ras GTPase activating proteins are quite large from 765 residues for sar1 to 3079 residues for IRA2 but share only a limited about 250 residues region of sequence similarity, referred to as the catalytic domain or rasGAP domain. Note There are distinctly different GAPs for the rap and rho rac subfamilies of ras like proteins reviewed in reference ref name PUB00004162 cite journal author McCormick F, Boguski MS ... Neurofibromin 1 NF1 RAS p21 protein activator 1 RASA1 RASA2 RASA3 RASA4 RASAL1 RASAL2 SYNGAP1 References ... more details
protein Name D amino acid oxidase activator caption image width HGNCid 21191 Symbol DAOA AltSymbols G72, LG72, SG72 EntrezGene 267012 OMIM 607408 RefSeq NM 172370 UniProt P59103 PDB ECnumber Chromosome 13 Arm q Band 33.2 LocusSupplementaryData D amino acid oxidase activator DAOA , also known as G72 is a protein enriched in various parts of brain, spinal cord, and testis. DAOA is thought to interact with D amino acid oxidase , a peroxisomal enzyme, and its gene was associated with schizophrenia in a number of studies. ref name pmid16581030 cite journal author Detera Wadleigh SD, McMahon FJ title G72 G30 in schizophrenia and bipolar disorder review and meta analysis journal Biol. Psychiatry volume 60 issue 2 pages 106 14 year 2006 pmid 16581030 doi 10.1016 j.biopsych.2006.01.019 ref ref name SZGeneDAOA http www.schizophreniaforum.org res sczgene geneoverview.asp?geneid 289 Gene Overview of All Published Schizophrenia Association Studies for DAOA , schizophreniaforum.org ref In separate studies it has been shown to confer susceptibility to bipolar disorder. Therefore it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22 q34 region, ref name pmid12364586 cite journal author Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz Fuertes R, Meguenni S, Aurich Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham ... more details
Transcription Activator Like Effector Nuclease s TALENs are artificial restriction enzyme s generated by fusing the TAL effector DNA binding domain to a DNA cleavage domain. Use These reagents enable efficient, programmable, and specific DNA cleavage and represent powerful tools for genome editing in situ . Synthetic transcription factors using TALE domain constructs can also be used for gene regulation by pairing the TALE DNA binding domain with an endogenous activation domain affecting expression at specific sites in complex genomes. ref name Morbitzer2010 Cite doi 10.1073 pnas.1013133107 ref ref name Miller2011 cite journal last Miller first Jeffrey coauthors et.al. title A TALE nuclease architecture for efficient genome editing journal Nature Biotechnology year 2011 month February volume 29 issue 2 pages 143 8 doi 10.1038 nbt.1755 pmid 21179091 ref ref name Zhang2011 cite journal last Zhang first Feng coauthors et.al. title Efficient construction of sequence specific TAL effectors for modulating mammalian transcription journal Nature Biotechnology year 2011 month February volume 29 issue 2 pages 149 53 doi 10.1038 nbt.1775 pmid 21248753 pmc 3084533 ref ref name Geissler2011 Cite doi 10.1371 journal.pone.0019509 ref Transcription activator like effectors TALEs can be quickly engineered to bind practically any DNA sequence. ref name Boch2011 cite journal last Boch first Jens title TALEs of genome targeting journal Nature Biotechnology year 2011 month February volume 29 issue 2 pages 135 6 doi 10.1038 nbt.1767 pmid 21301438 ref DNA binding domain TAL effector s are proteins secreted by Xanthomonas bacteria. The DNA binding domain contains a highly conserved 33 34 amino acid sequence with the exception of the 12th and 13th amino acids. These two locations are highly variable Repeat Variable Diresidue and show a strong correlation with specific nucleotide recognition. ref ... engineered transcription activator like effector TALE hybrid nuclease with novel DNA binding specificity ... more details
PBB geneid 5921 RAS p21 protein activator 1 or RasGAP Ras GTPase activating protein , also known as RASA1 , is a 120 kDa cytosolic human protein that provides two principal activities Inactivation of Ras protein Ras from its active Guanosine triphosphate GTP bound form to its unactive Guanosine diphosphate GDP bound form by enhancing the endogenous GTPase activity of Ras, via its C terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N terminal SH2 SH3 SH2 domains The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. ref cite web title Entrez Gene RASA1 RAS p21 protein activator GTPase activating protein 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5921 accessdate ref Domains RasGAP contains one SH3 domain and two SH2 domain s, a PH domain , and a GAP domain . Interactions RAS p21 protein activator 1 has been shown to Protein protein interaction interact with SOCS3 , ref name pmid11331873 cite journal last Cacalano first N A authorlink coauthors Sanden D, Johnston J A year 2001 month May. title Tyrosine phosphorylated ... more details
Refimprove date February 2012 Unlike Allosteric regulation allosteric activators , which induce enzymatic activity, obligate activators are required for enzymatic activity. 2 examples ref Kaplan, Inc. Kaplan Biochemistry Notes Lecture 2010 ref are Acetyl CoA for Pyruvate carboxylase Gluconeogenesis N acetylglutamate for Carbamoyl phosphate synthase I Urea cycle References Reflist Category Enzyme kinetics ... more details
RTPA may refer to Radiotelevisi n del Principado de Asturias , a public broadcasting company in Asturias, Spain. rtPA may refer to Tissue plasminogen activator Recombinant tissue plasminogen activator , a protein involved in the breakdown of blood clots. disambig ... more details
CDH1 may refer to Huntsville Deerhurst Resort Airport CDH1 gene classical cadherin from the cadherin superfamily APC C activator protein CDH1 Cell cycle regulated activator of the anaphase promoting complex cyclosome APC C Letter NumberCombDisambig Long comment to avoid being listed on short pages ... more details
Plasminogen activators can refer to Tissue plasminogen activator Urinary plasminogen activator also known as urokinase disambig Short pages monitor This long comment was added to the page to prevent it being listed on Special Shortpages. It and the accompanying monitoring template were generated via Template Longcomment. Please do not remove the monitor template without removing the comment as well. ... more details
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