PBB geneid 100 Infobox protein family Symbol A deaminase Name Adenosine AMP deaminase image PDB 2amx EBI.jpg width caption crystal structure of plasmodium yoelii adenosinedeaminase py02076 Pfam PF00962 ... CAZy CDD Infobox protein family Symbol A deamin Name Adenosinedeaminase editase domain image width caption crystal structure of the catalytic domain of an adenosinedeaminase that acts on rna ... N Name Adenosine AMP deaminase N terminal image width caption crystal structure of human adenosinedeaminase growth factor, adenosinedeaminase type 2 ada2 complexed with transition state analogue ... OPM protein CAZy CDD Adenosinedeaminase also known as adenosine aminhydrolase, or ADA is an enzyme ... G proteins. ref name eight Pathology Some mutation s in the gene for adenosinedeaminase ... mutation in the adenosinedeaminase ADA gene implies a high incidence of ADA deficient severe combined ... author Chottiner EG, Cloft HJ, Tartaglia AP, Mitchell BS title Elevated adenosinedeaminase activity ... pmid11121182 cite journal author Persico AM, Militerni R, Bravaccio C, et al. title Adenosinedeaminase ... of a patient with combined immunodeficiency disease and adenosinedeaminase deficiency journal ... and board review, chapter 18 question 16 ref See also Adenosinedeaminase deficiency References ... title Adenosinedeaminase. A pluridisciplinary enzyme journal Acta m dica portuguesa volume 4 issue .... title Cell surface adenosinedeaminase much more than an ectoenzyme journal Prog. Neurobiol. volume ... E, et al. title Presence of adenosinedeaminase on the surface of mononuclear blood cells immunochemical ... activity of human erythrocyte adenosinedeaminase journal Mol. Cell. Biochem. volume 86 issue 2 ... Murray JL, Perez Soler R, Bywaters D, Hersh EM title Decreased adenosinedeaminase ADA and 5 nucleotidase ... K title Elevated red cell adenosinedeaminase activity a marker of disordered erythropoiesis in Diamond ... MB, Tranebjaerg L, Tommerup N, et al. title New assignment of the adenosinedeaminase gene locus to chromosome ... more details
enzyme Name adenosine phosphate deaminase EC number 3.5.4.17 CAS number 37289 20 6 IUBMB EC number 3 5 4 17 GO code 0047623 image width caption In enzymology , an adenosine phosphate deaminase EC number 3.5.4.17 is an enzyme that catalysis catalyzes the chemical reaction 5 AMP H sub 2 sub O math rightleftharpoons math 5 IMP NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are 5 AMP and water H sub 2 sub O , whereas its two product chemistry products are 5 IMP and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenosine phosphate aminohydrolase . Other names in common use include adenylate deaminase , adenine nucleotide deaminase , and adenosine phosphate deaminase . References reflist 1 cite journal author Su JC, Li CC, Ting CC date 1966 title A new adenylate deaminase from red marine alga Porphyra crispata journal Biochemistry. volume 5 pages 536&ndash 43 pmid 5940938 doi 10.1021 bi00866a020 issue 2 cite journal author Yates MG date 1969 title A non specific adenine nucleotide deaminase from desulfovibrio desulfuricans journal Biochim. Biophys. Acta. volume 171 pages 299&ndash 310 pmid 5773435 issue 2 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
refimprove date March 2008 Infobox Disease Name Adenosinedeaminase deficiency Image Caption DiseasesDB 260 ICD10 ICD10 D 81 3 d 80 ICD9 ICD9 279.2 ICDO OMIM 102700 MedlinePlus eMedicineSubj eMedicineTopic MeshID Adenosinedeaminase deficiency , also called ADA deficiency or ADA SCID , ref name omim OMIM 102700 ref is an autosome autosomal dominance genetics recessive ref cite journal pmid 477037 year 1979 month September author Hirschhorn R, Vawter GF, Kirkpatrick JA Jr., Rosen FS title Adenosinedeaminase deficiency frequency and comparative pathology in autosomally recessive severe combined immunodeficiency volume 14 issue 1 pages 107 20 journal Clinical immunology and immunopathology doi 10.1016 0090 1229 79 90131 4 ref metabolic disorder that causes immunodeficiency . It occurs in fewer ... title Genotype is an important determinant of phenotype in adenosinedeaminase deficiency volume 15 ... S, Hershfield MS title Adenosinedeaminase deficiency genotype phenotype correlations based ... of the enzyme adenosinedeaminase . This deficiency results in an accumulation of deoxyadenosine , ref name titleAdenosine Deaminase ADA Deficiency cite web url http learn.genetics.utah.edu units disorders whataregd ada title AdenosineDeaminase ADA Deficiency accessdate 2008 02 28 format work archiveurl ... adenosinedeaminase is important in the purine salvage pathway both substances are toxic to immature ... is severely compromised or completely lacking. Genetics Image Autorecessive.svg thumb right Adenosinedeaminase deficiency has an autosomal recessive pattern of inheritance . The enzyme adenosinedeaminase ... condition adenosinedeaminasedeficiency Adenosinedeaminase deficiency Genetics Home Reference http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part ada GeneReviews NCBI NIH UW entry on AdenosineDeaminase Deficiency Immune disorders Purine, pyrimidine, porphyrin, bilirubin metabolic pathology DEFAULTSORT AdenosineDeaminase Deficiency Category Autosomal recessive disorders Category Rare ... more details
Infobox disease Name Adenosine Monophosphate Deaminase Deficiency type 1 Image AMP structure.svg Caption Adenosine monophosphate DiseasesDB ICD10 ICD9 ICDO OMIM 102770 MedlinePlus eMedicineSubj eMedicineTopic MeshID Adenosine monophosphate deaminase deficiency type 1 is also called myoadenylate deaminase ... of European descent. ref name ghr2008 cite web url http ghr.nlm.nih.gov condition adenosine monophosphate deaminase deficiency title Adenosine monophosphate deaminase deficiency work Genetics ... this is AMP deaminase ref name ghr2008 though there is also an acquired form of AMP deficiency. Causes AMP deaminase is an enzyme that converts adenosine monophosphate AMP to inosine monophosphate IMP ... Without myoadenlyate deaminase, heavy activity causes adenosine to be released into the cell or perfused ... one of the above fuels into adenosine triphosphate ATP via the mitochondrion mitochondria . Cellular processes, especially muscle s, then convert the ATP into adenosine diphosphate ADP , freeing the energy ... ATP available to supply energy. AMP is normally converted into IMP by myoadenylate deaminase so myoadenylate deaminase deficiency reduces energy that would be available to the cell through the Purine ... AMP, increasing levels of cellular and circulating adenosine by 16x 25x. ref cite journal pages 720 30 doi 10.1172 JCI111265 title Myoadenylate deaminase deficiency. Functional and metabolic abnormalities ... of adenosine, another vasodilator. ref cite journal pmid 9576114 title Role of nitric oxide in adenosine ... cramping. ref cite web url http www.mda.org disease mad.html title Myoadenylate Deaminase Deficiency ... adenosine in the cells which signals muscle fiber to feel fatigued. In the brain, excess adenosine decreases alertness and causes sleepiness. In this way, adenosine may play a role in fatigue from ... due to high levels of lactate. Increased levels of free adenosine temporarily decrease pain, allowing ... Hansson first5 Per title Systemic Adenosine Infusion Alleviates Spontaneous and Stimulus Evoked Pain ... more details
adenosine enters the circulation, it is broken down by adenosinedeaminase , which is present in red blood cell red cell s and the vessel wall. Dipyridamole , an inhibitor of adenosinedeaminase , allows .... Adenosinedeaminase deficiency is a known cause of immunodeficiency. Analogs and viruses The adenosine ... 9 yl 5 hydroxymethyl oxolane 3,4 diol image Adenosin.svg image2 Adenosine spacefilling.png Clinical data tradename Adenocard Drugs.com drugs.com monograph adenosine pregnancy AU A B1 B2 B3 C D X pregnancy ... bound No metabolism Rapidly converted to inosine and adenosine monophosphate elimination half life cleared ... KQYNXXCUSA N Adenosine Ado is a purine nucleoside comprising a molecule of adenine attached ... . Adenosine plays an important role in biochemistry biochemical processes, such as energy transfer as adenosine triphosphate ATP and adenosine diphosphate ADP as well as in signal transduction as cyclic adenosine monophosphate , cAMP. It is also an inhibitory neurotransmitter, believed to play a role .... Pharmacological effects Adenosine is an endogenous purine nucleoside that modulates many physiological processes. Cellular signaling by adenosine occurs through four known adenosine receptor subtypes adenosine A1 receptor A1 , adenosine A2A receptor A2A , adenosine A2B receptor A2B , and adenosine ... P title Adenosine receptors therapeutic aspects for inflammatory and immune diseases journal Nat ... 10.1038 nrd2638 ref Extracellular adenosine concentrations from normal cells are approximately 300 ... are quickly elevated 600 1,200 nM . Thus, in regard to stress or injury, the function of adenosine ... Adenosine receptors Main Adenosine receptor The different adenosine receptor subtypes A1, A2A, A2B ... cyclase, while the A1 and A3 adenosine receptors couple to G sub i sub which inhibits adenylate cyclase ... adenosine inhibition of Ca2 conductance, whereas A2B and A3 receptors also couple to G sub q sub and stimulate phospholipase activity. Anti inflammatory properties Adenosine is believed to be an anti ... more details
enzyme Name ADP deaminase EC number 3.5.4.7 CAS number 9027 79 6 IUBMB EC number 3 5 4 7 GO code 0047629 image width caption In enzymology , an ADP deaminase EC number 3.5.4.7 is an enzyme that catalysis catalyzes the chemical reaction ADP H sub 2 sub O math rightleftharpoons math IDP NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and water H sub 2 sub O , whereas its two product chemistry products are IDP and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is ADP aminohydrolase . Other names in common use include adenosine diphosphate deaminase , and adenosinepyrophosphate deaminase . References reflist 1 cite journal author Deutsch A and Nilsson R date 1954 title On the dephosphorylation and deamination of adenosine triphosphate by actomyosin gel journal Acta Chem. Scand. volume 8 pages 1898&ndash 1906 doi 10.3891 acta.chem.scand.08 1898 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
enzyme Name ATP deaminase EC number 3.5.4.18 CAS number 37289 21 7 IUBMB EC number 3 5 4 18 GO code 0047692 image width caption In enzymology , an ATP deaminase EC number 3.5.4.18 is an enzyme that catalysis catalyzes the chemical reaction ATP H sub 2 sub O math rightleftharpoons math ITP NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and water H sub 2 sub O , whereas its two product chemistry products are ITP and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is ATP aminohydrolase . This enzyme is also called adenosine triphosphate deaminase . References reflist 1 cite journal author Chung ST, Aida K date Tokyo title Purification and properties of ATP deaminase from Microsporum audouini journal J. volume Biochem. pages 1&ndash 9 pmid 6048966 issue 1 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
EntrezGene 270 ref Adenosine monophosphate deaminase is an enzyme that converts adenosine monophosphate AMP to inosine monophosphate IMP , freeing an ammonia molecule in the process. Function Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays ... title Radioisotopic assay for erythrocyte adenosine 5 monophosphate deaminase. journal Clin. Chim. Acta ...PBB geneid 270 AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene . ref name pmid1400401 cite journal author Mahnke Zizelman DK, Sabina RL title Cloning of human AMP deaminase isoform ... In order to use energy, a cell biology cell converts one of the above fuels into adenosine triphosphate ... into adenosine diphosphate ADP , freeing the energy to do work. Citation needed date January ... kinase by directly inhibiting AMP deaminase, thereby increasing cellular AMP. ref name pmid21059655 ... of AMP deaminase journal J. Biol. Chem. volume 286 issue 1 pages 1 11 year 2011 month January ... ref Pathology A deficiency is associated with myoadenylate deaminase deficiency . gallery Image AMP structure.svg adenosine monophosphate AMP Image Inosine monophosphate.svg inosine monophosphate IMP ... VW, Griffin JL title Myoadenylate deaminase deficiency a new disease of muscle. journal Science ... Sabina RL, Fishbein WN, Pezeshkpour G, et al. title Molecular analysis of the myoadenylate deaminase ... author Morisaki T, Gross M, Morisaki H, et al. title Molecular basis of AMP deaminase deficiency ... P, et al. title Characterization of the human and rat myoadenylate deaminase genes. journal J. Biol ... author Mercelis R, Martin JJ, Dehaene I, et al. title Myoadenylate deaminase deficiency in a patient ... Kelemen J, Rice DR, Bradley WG, et al. title Familial myoadenylate deaminase deficiency and exertional ... author Baumeister FA, Gross M, Wagner DR, et al. title Myoadenylate deaminase deficiency with severe ... S, et al. title Combined defects of muscle phosphofructokinase and AMP deaminase in a child with myoglobinuria ... more details
adenosinedeaminase and cytidine deaminase activities in patients with systemic lupus erythematosus ...PBB geneid 978 Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene . ref name pmid8422236 ... cytidine deaminase CDD and its use as a marker of monocyte macrophage differentiation journal ... deaminase journal Biochim Biophys Acta volume 1443 issue 3 pages 323 33 year 1999 month Feb pmid 9878810 pmc doi ref ref name entrez cite web title Entrez Gene CDA cytidine deaminase url http www.ncbi.nlm.nih.gov ... of certain childhood leukemias. ref name entrez cite web title Entrez Gene CDA cytidine deaminase ... R title On the interaction of 3,4,5,6 tetrahydrouridine with human liver cytidine deaminase. journal ... journal author Lalibert J, Momparler RL title Human cytidine deaminase purification of enzyme, cloning ... of the human cytidine deaminase CDA gene to chromosome 1 band p35 p36.2. journal Genomics volume ... by human cytidine deaminase requires the catalytic function of the protein. journal Blood volume ... A, et al. title Intracellular localization of human cytidine deaminase. Identification of a functional ... induced cytidine deaminase deaminates deoxycytidine on single stranded DNA but requires the action of RNase ... Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia journal ... cytidine deaminase. journal Nucleosides Nucleotides Nucleic Acids volume 22 issue 5 8 pages 1535 ... A, et al. title Human cytidine deaminase understanding the catalytic mechanism. journal Nucleosides ... NCN 120023029 cite journal author Ge Y, Jensen TL, Stout ML, et al. title The role of cytidine deaminase ... al. title Functional properties of subunit interactions in human cytidine deaminase. journal Protein ... SJ, Fromme JC, Verdine GL title Structure of human cytidine deaminase bound to a potent inhibitor ... cytidine deaminase. journal Protein Eng. Des. Sel. volume 17 issue 12 pages 871 7 year 2005 pmid ... A title Human cytidine deaminase a three dimensional homology model of a tetrameric metallo enzyme ... more details
SMILES O P O O OC C H 3O C H n2cnc1c ncnc12 N C H O C H 3O MeSHName Adenosine monophosphate Section2 ... FlashPt Autoignition Adenosine monophosphate AMP , also known as 5 adenylic acid , is a nucleotide that is used as a monomer in RNA . It is an ester of phosphoric acid and the nucleoside adenosine ... Adenosine triphosphate ATP synthesis by the enzyme adenylate kinase by combining two Adenosine ... phosphate bond of ADP ADP AMP phosphate P sub i sub AMP can also be formed by hydrolysis of Adenosine ... down by living systems, nucleoside monophosphates, including adenosine monophosphate, are formed. AMP ... AMP can be converted into inosine monophosphate IMP by the enzyme myoadenylate deaminase , freeing an ammonia group. In a catabolic pathway, adenosine monophosphate can be converted to uric ... adenosine monophosphate cyclic AMP or cAMP . Within certain cells the enzyme adenylate cyclase ... ur Adenosine monophosphate zh ... more details
enzyme Name adenosine kinase EC number 2.7.1.20 CAS number 9027 72 9 IUBMB EC number 2 7 1 20 GO code 0004001 image PDB 1lio EBI.jpg width 200px caption Cartoon representation of the molecular structure of protein registered with 1lio code. In enzymology , an adenosine kinase EC number 2.7.1.20 is an enzyme that catalysis catalyzes the chemical reaction ATP adenosine math rightleftharpoons math ADP AMP Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and adenosine , whereas its two product chemistry products are adenosine diphosphate ADP and adenosine monophosphate AMP . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP adenosine 5 phosphotransferase . This enzyme is also called adenosine kinase phosphorylating . This enzyme participates in purine metabolism . Structural studies As of late 2007, 16 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB2 1BX4 , PDB2 1DGM , PDB2 1LII , PDB2 1LIJ , PDB2 1LIK , PDB2 1LIO , PDB2 2A9Y , PDB2 2A9Z , PDB2 2AA0 , PDB2 2AB8 , PDB2 2ABS , PDB2 2GL0 , PDB2 2PKF , PDB2 2PKK , PDB2 2PKM , and PDB2 2PKN . References reflist 1 cite journal author Lindberg B, Klenow H, Hansen K date 1967 title Some properties of partially purified mammalian adenosine kinase journal J. Biol. Chem. volume 242 pages 350&ndash 6 pmid 4290214 issue 3 cite journal author CAPUTTO R date 1951 title The enzymatic synthesis of adenylic acid adenosinekinase journal J. Biol. Chem. volume 189 pages 801&ndash 14 pmid 14832298 issue 2 cite journal author Kornberg A and Pricer WE date 1951 title Enzymatic phosphorylation of adenosine and 2,6 diaminopurine riboside journal J. Biol. Chem. volume 193 issue 2 pages 481&ndash 495 pmid 14907737 enzyme stub Category EC 2.7.1 Category Enzymes of known ... more details
enzyme Name adenosine nucleosidase EC number 3.2.2.7 CAS number 9075 41 6 IUBMB EC number 3 2 2 7 GO code 0047622 image width caption In enzymology , an adenosine nucleosidase EC number 3.2.2.7 is an enzyme that catalysis catalyzes the chemical reaction adenosine H sub 2 sub O math rightleftharpoons math D ribose adenine Thus, the two substrate biochemistry substrates of this enzyme are adenosine and water H sub 2 sub O , whereas its two product chemistry products are D ribose and adenine . This enzyme belongs to the family of hydrolase s, specifically those glycosylases that hydrolyse N glycosyl compounds. The systematic name of this enzyme class is adenosine ribohydrolase . Other names in common use include adenosinase , N ribosyladenine ribohydrolase , adenosine hydrolase , and ANase . This enzyme participates in purine metabolism . References reflist 1 cite journal author MAZELIS M, CREVELING RK date 1963 title AN ADENOSINE HYDROLASE FROM BRUSSELS SPROUTS journal J. Biol. Chem. volume 238 pages 3358&ndash 61 pmid 14085386 hydrolase stub Category EC 3.2.2 Category Enzymes of unknown structure ... more details
enzyme Name pterin deaminase EC number 3.5.4.11 CAS number 9025 04 1 IUBMB EC number 3 5 4 11 GO code 0050228 image width caption In enzymology , a pterin deaminase EC number 3.5.4.11 is an enzyme that catalysis catalyzes the chemical reaction 2 amino 4 hydroxypteridine H sub 2 sub O math rightleftharpoons math 2,4 dihydroxypteridine NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are 2 amino 4 hydroxypteridine and water H sub 2 sub O , whereas its two product chemistry products are 2,4 dihydroxypteridine and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 2 amino 4 hydroxypteridine aminohydrolase . This enzyme is also called acrasinase . References reflist 1 cite journal author LEVENBERG B, HAYAISHI O date 1959 title A bacterial pterin deaminase journal J. Biol. Chem. volume 234 pages 955&ndash 61 pmid 13654299 issue 4 cite journal author Rembold H, Simmersbach F date 1969 title Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver journal Biochim. Biophys. Acta. volume 184 pages 589&ndash 96 pmid 5821022 issue 3 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
enzyme Name S adenosylhomocysteine deaminase EC number 3.5.4.28 CAS number 125149 24 8 IUBMB EC number 3 5 4 28 GO code 0050270 image width caption In enzymology , a S adenosylhomocysteine deaminase EC number 3.5.4.28 is an enzyme that catalysis catalyzes the chemical reaction S adenosyl L homocysteine H sub 2 sub O math rightleftharpoons math S inosyl L homocysteine NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are S adenosyl L homocysteine and water H sub 2 sub O , whereas its two product chemistry products are S inosyl L homocysteine and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is S adenosyl L homocysteine aminohydrolase . This enzyme is also called adenosylhomocysteine deaminase . References reflist 1 cite journal author Zulty JJ, Speedie MK date 1989 title Purification and characterization of S adenosylhomocysteine deaminase from streptonigrin producing Streptomyces flocculus journal J. Bacteriol. volume 171 pages 6840&ndash 4 pmid 2592350 issue 12 pmc 210584 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
enzyme Name adenosine tetraphosphatase EC number 3.6.1.14 CAS number 37289 26 2 IUBMB EC number 3 6 1 14 GO code 0047624 image width caption In enzymology , an adenosine tetraphosphatase EC number 3.6.1.14 is an enzyme that catalysis catalyzes the chemical reaction adenosine 5 tetraphosphate H sub 2 sub O math rightleftharpoons math ATP phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine 5 tetraphosphate and water H sub 2 sub O , whereas its two product chemistry products are adenosine triphosphate ATP and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is adenosine tetraphosphate phosphohydrolase . This enzyme participates in purine metabolism . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 2V7Q . References reflist 1 cite journal author Small GD, Cooper C date 1966 title Purification and properties of nucleoside tetraphosphate hydrolase from rabbit muscle journal Biochemistry. volume 5 pages 14&ndash 26 pmid 4287215 doi 10.1021 bi00865a003 issue 1 hydrolase stub Category EC 3.6.1 Category Enzymes of known structure ... more details
enzyme Name dCTP deaminase EC number 3.5.4.13 CAS number 37289 18 2 IUBMB EC number 3 5 4 13 GO code 0008829 image width caption lowercase In enzymology , a dCTP deaminase EC number 3.5.4.13 is an enzyme that catalysis catalyzes the chemical reaction dCTP H sub 2 sub O math rightleftharpoons math dUTP NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are dCTP and water H sub 2 sub O , whereas its two product chemistry products are dUTP and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase . Other names in common use include deoxycytidine triphosphate deaminase , and 5 methyl dCTP deaminase . This enzyme participates in pyrimidine metabolism . Structural studies As of late 2007, 9 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1OGH , PDB link 1PKH , PDB link 1PKJ , PDB link 1PKK , PDB link 1XS1 , PDB link 1XS4 , PDB link 1XS6 , PDB link 2J4H , and PDB link 2J4Q . References reflist 1 cite journal author Tomita F, Takahashi I date 1969 title A novel enzyme, dCTP deaminase, found in Bacillus subtilis infected with phage PBS I journal Biochim. Biophys. Acta. volume 179 pages 18&ndash 27 pmid 4976547 issue 1 hydrolase stub Category EC 3.5.4 Category Enzymes of known structure ... more details
The adenosine receptors or P1 receptors ref name pmid9133776 cite journal author Fredholm BB, Abbracchio ... protein coupled receptor s with adenosine as endogenous ligand biochemistry ligand . ref name pmid11734617 ... Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors journal Pharmacol ... cgi content abstract 53 4 527 ref Pharmacology In humans, there are four types of adenosine .... ref name pmid17874974 cite journal author Gao ZG, Jacobson KA title Emerging adenosine receptor ... journal author Kalda A, Yu L, Oztas E, Chen JF title Novel neuroprotection by caffeine and adenosine ... title Adenosine receptor dopamine receptor interactions in the basal ganglia and their relevance for brain ... author Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferr S title Adenosine A2A receptors and basal ... of adenosine A2A receptors in psychiatric disorders journal Current Pharmaceutical Design volume ... in processes such as inflammation and immune responses. Most older compounds acting on adenosine receptors are nonselective, with the endogenous agonist adenosine being used in hospitals as treatment ... adenosine receptors in heart tissue, ref name pmid17999026 cite journal author Cohen MV, Downey JM title Adenosine trigger and mediator of cardioprotection journal Basic Research in Cardiology volume ... the opposite effect to adenosine, producing a stimulant effect and rapid heart rate. ref name pmid18088379 ... 3 pages 171 94 year 2007 month June pmid 17373584 doi 10.1007 s10557 007 6014 6 url issn ref Newer adenosine ... extensive research into the effects of blocking or stimulating the individual adenosine receptor ... uses. Some of these compounds are still derived from adenosine or from the xanthine family, but researchers in this area have also discovered many selective adenosine receptor ligands that are entirely ... pmid18181659 cite journal author Baraldi PG, Tabrizi MA, Gessi S, Borea PA title Adenosine receptor ... R, Dal Ben D title A2A adenosine receptor and its modulators overview on a druggable GPCR and on structure ... more details
enzyme Name 1 pyrroline 4 hydroxy 2 carboxylate deaminase EC number 3.5.4.22 CAS number 9054 77 7 IUBMB EC number 3 5 4 22 GO code 0047425 image width caption In enzymology , a 1 pyrroline 4 hydroxy 2 carboxylate deaminase EC number 3.5.4.22 is an enzyme that catalysis catalyzes the chemical reaction 1 pyrroline 4 hydroxy 2 carboxylate H sub 2 sub O math rightleftharpoons math 2,5 dioxopentanoate NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are 1 pyrroline 4 hydroxy 2 carboxylate and water H sub 2 sub O , whereas its two product chemistry products are 2,5 dioxopentanoate and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1 pyrroline 4 hydroxy 2 carboxylate aminohydrolase decyclizing . This enzyme is also called HPC deaminase . This enzyme participates in arginine and proline metabolism . References reflist 1 cite journal author Singh RMM and Adams E date 1965 title Enzymatic deamination of Delta1 pyrroline 4 hydroxy 2 carboxylate to 2,5 dioxovalerate alpha ketoglutaric semialdehyde journal J. Biol. Chem. volume 240 pages 4344&ndash 4351 cite journal author Singh RMM and Adams E date 1965 title Isolation and identification of 2,5 dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline journal J. Biol. Chem. volume 240 issue 11 pages 4352&ndash 4356 pmid 5845839 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
enzyme Name blasticidin S deaminase EC number 3.5.4.23 CAS number 54576 55 5 IUBMB EC number 3 5 4 23 GO code 0047711 image width caption In enzymology , a blasticidin S deaminase EC number 3.5.4.23 is an enzyme that catalysis catalyzes the chemical reaction blasticidin S H sub 2 sub O math rightleftharpoons math deaminohydroxyblasticidin S NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are blasticidin S and water H sub 2 sub O , whereas its two product chemistry products are deaminohydroxyblasticidin S and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin S aminohydrolase . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1WN5 and PDB link 1WN6 . References reflist 1 cite journal author Yamaguchi I, Shibata H, Seto H, Misato T date Tokyo title Isolation and purification of blasticidin S deaminase from Aspergillus terreus journal J. volume Antibiot. pages 7&ndash 14 pmid 236272 issue 1 hydrolase stub Category EC 3.5.4 Category Enzymes of known structure ... more details
enzyme Name guanosine deaminase EC number 3.5.4.15 CAS number 9067 85 0 IUBMB EC number 3 5 4 15 GO code 0047974 image width caption In enzymology , a guanosine deaminase EC number 3.5.4.15 is an enzyme that catalysis catalyzes the chemical reaction guanosine H sub 2 sub O math rightleftharpoons math xanthosine NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are guanosine and water H sub 2 sub O , whereas its two product chemistry products are xanthosine and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is guanosine aminohydrolase . This enzyme is also called guanosine aminase . References reflist 1 cite journal author Isihida Y, Shirafiji H, Kida M and Yoneda M date 1969 title Studies on the guanosine degrading system in bacterial cell. III Preparation and properties of guanosine deaminase journal Agric. Biol. Chem. volume 33 pages 384&ndash 390 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
enzyme Name sepiapterin deaminase EC number 3.5.4.24 CAS number 62213 22 3 IUBMB EC number 3 5 4 24 GO code 0050279 image width caption In enzymology , a sepiapterin deaminase EC number 3.5.4.24 is an enzyme that catalysis catalyzes the chemical reaction sepiapterin H sub 2 sub O math rightleftharpoons math xanthopterin B sub 2 sub NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are sepiapterin and water H sub 2 sub O , whereas its two product chemistry products are xanthopterin xanthopterin B2 and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is sepiapterin aminohydrolase . References reflist 1 cite journal author Tsusue M date Tokyo title Studies on sepiapterin deaminase from the silkworm, Bombyx mori Purification and some properties of the enzyme journal J. volume Biochem. pages 781&ndash 8 pmid 5572808 issue 4 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
enzyme Name cytosine deaminase EC number 3.5.4.1 CAS number 9025 05 2 IUBMB EC number 3 5 4 1 GO code 0004131 image width caption In enzymology , a cytosine deaminase EC number 3.5.4.1 is an enzyme that catalysis catalyzes the chemical reaction cytosine H sub 2 sub O math rightleftharpoons math uracil NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are cytosine and water H sub 2 sub O , whereas its two product chemistry products are uracil and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase . This enzyme is also called isocytosine deaminase . This enzyme participates in pyrimidine metabolism . Structural studies As of late 2007, 13 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1K6W , PDB link 1K70 , PDB link 1OX7 , PDB link 1P6O , PDB link 1R9X , PDB link 1R9Y , PDB link 1RA0 , PDB link 1RA5 , PDB link 1RAK , PDB link 1RB7 , PDB link 1UAQ , PDB link 1YSB , and PDB link 1YSD . References reflist 1 cite journal author COHEN SS, BARNER HD date 1957 title The conversion of 5 methyldeoxycytidine to thymidine in vitro and in vivo journal J. Biol. Chem. volume 226 pages 631&ndash 42 pmid 13438848 issue 2 cite journal author Kream J and Chargaff E date 1952 title On the cytosine deaminase of yeast journal J. Am. Chem. Soc. volume 74 issue 20 pages 5157&ndash 5160 doi 10.1021 ja01140a050 hydrolase stub Category EC 3.5.4 Category Enzymes of known structure ... more details
BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Adenosine diphosphate ... adenosine . ADP consists of the pyrophosphate Functional group group , the pentose sugar ribose , and the nucleobase adenine . ADP is the product of adenosine triphosphate ATP dephosphorylation ... is converted to adenosine by the action of ecto ADPases, inhibiting further platelet activation via adenosine receptor s. ADP is the end product that results when ATP loses one of its phosphate groups located at the end of the molecule. ref name hyperphysics.phy astr.gsu.edu Nave, C.R. Adenosine ... Nucleotide Adenine Ribose DNA RNA Oligonucleotide Adenosine triphosphate Adenosine monophosphate ... difosfato ru simple Adenosine diphosphate sr sh Adenozin difosfat fi Adenosiinidifosfaatti sv Adenosindifosfat tr Adenozin difosfat uk ur Adenosine diphosphate vi Adenosine diphosphate zh ... more details
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