March 2009 Infobox protein family Symbol Serum albumin Name Serum albumin family image PDB 1ao6 EBI.jpg width caption Structure of human serum albumin. ref cite journal author Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K title Crystal structure of human serum albumin at 2.5 A resolution journal ... and chemistry of human serum albumin. journal Nature year 1992 volume 358 issue 6383 pages 209 15 ... , PDB2 2vue , PDB2 2vuf , PDB2 3b9l , PDB2 3b9m Albumin Latin albus, white refers generally to any ... containing albumin, such as egg white , are called albuminoids . A number of blood transport protein s are known to be evolutionarily related, including serum albumin , alpha fetoprotein , vitamin ... JE, Schoenberg DR, Wahli W title Amphibian albumins as members of the albumin, alpha fetoprotein, vitamin ... homology as in serum albumin and alpha fetoprotein journal Biochim. Biophys. Acta volume 871 issue ... JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM title Afamin is a new member of the albumin ... blood volume, there is no evidence that albumin reduces mortality when compared with cheaper alternatives such as normal saline , or that albumin reduces mortality in patients with burns and low albumin levels. Therefore, the Cochrane Collaboration recommends that it not be used, except in clinical ... title Human albumin solution for resuscitation and volume expansion in critically ill patients year 2011 journal Cochrane Database Syst Rev pages CD001208 ref Function Albumin is the main protein of plasma ... D and its metabolites, as well as to fatty acids. The biological role of afamin alpha albumin has not yet ... albumin has been determined by X ray crystallography to a resolution of 2.5 . ref name pmid10388840 ... of human serum albumin at 2.5 A resolution. journal Protein Engineering volume 12 issue 6 pages ... content 12 6 439.full issn ref Albumin comprises three homologous domains that assemble to form ... albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry ... more details
About the family of mammalian albumin proteins the human variant human serum albumin the cow variant bovine serum albumin PBB geneid 213 Serum albumin , often referred to simply as albumin is a protein ... A title The human serum albumin gene structure of a unique locus journal Gene volume 19 issue ... cite journal author Harper ME, Dugaiczyk A title Linkage of the evolutionarily related serum albumin ... entrez cite web title Entrez Gene albumin url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 213 accessdate ref Serum albumin is the most abundant plasma protein in mammal s. Albumin is essential for maintaining the osmotic pressure needed for proper distribution of body ... and fatty acid s. Too much serum albumin in the body can be harmful. Function Major contributors to oncotic pressure known also as colloid osmotic pressure of plasma carriers for various substances. Albumin is a soluble, monomeric protein which comprises about one half of the blood serum protein. Albumin ... a role in stabilizing extracellular fluid volume. Albumin is a globular un glycosylation glycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin ... Golgi vesicle s to produce the secreted albumin. ref name entrez Types Serum albumin is widely distributed in mammals. Examples include The human version is human serum albumin . Bovine serum albumin , or BSA, is commonly used in immunodiagnostic procedures, clinical chemistry reagents, cell ... non specific protein binding properties . Physical properties Albumin when ionized in water at pH ... charged in the body some studies suggest that this prevents the filtration of albumin in the urine. According to this theory, that charge plays a major role in the selective exclusion of albumin from the glomerular filtrate. A defect in this property results in nephrotic syndrome leading to albumin loss in the urine. Nephrotic syndrome patients are sometimes given albumin to replace the lost albumin ... more details
Diagnostic infobox Name CSF albumin Image Alt Caption DiseasesDB ICD10 ICD9 ICDO MedlinePlus eMedicine MeshID LOINC LOINC 1746 7 MCnc BR LOINC 2861 3 MCnc , electrophoresis BR LOINC 43711 1 ACnc HCPCSlevel2 Reference range CSF albumin is a measurement used to determine the levels of albumin in cerebrospinal fluid . ref name pmid10585175 cite journal author Murakami K, Nakagawa T, Shozu M, Uchide K, Koike K, Inoue M title Changes with aging of steroidal levels in the cerebrospinal fluid of women journal Maturitas volume 33 issue 1 pages 71 80 year 1999 month September pmid 10585175 doi 10.1016 S0378 5122 99 00040 7 url http linkinghub.elsevier.com retrieve pii S0378 5122 99 00040 7 ref A closely related test, CSF total protein is a measurement used to determine the levels of protein in cerebrospinal fluid . ref name urlMedlinePlus Medical Encyclopedia CSF total protein cite web url http www.nlm.nih.gov medlineplus ency article 003628.htm title MedlinePlus Medical Encyclopedia CSF total protein work accessdate ref ref name pmid14524396 cite journal author Seehusen DA, Reeves MM, Fomin DA title Cerebrospinal fluid analysis journal Am Fam Physician volume 68 issue 6 pages 1103 8 year 2003 month September pmid 14524396 doi url http www.aafp.org afp 20030915 1103.html ref It combines the albumin, IgG , and other proteins. It can be useful in distinguishing among causes of Meningitis . It is more likely to be elevated in bacterial meningitis than in viral meningitis . The upper normal range is 150 mg dl in neonates, and 50 mg dl in adults. ref name isbn0 07 140816 9 cite book author Karen Roos title Principles of neurologic infectious diseases publisher McGraw Hill, Medical Pub. Division location New York year 2005 pages 4 isbn 0 07 140816 9 oclc doi accessdate ref References div style float right border solid 10px white Test sample values div Reflist CSF tests Category Body fluids Category CSF tests medicine stub ... more details
Drugbox Verifiedfields changed verifiedrevid 477314998 IUPAC name image Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite changed ?? CAS number 9006 52 4 ATC prefix A07 ATC suffix XA01 PubChem DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA Chemical data chemical formula molecular weight Albumin tannate also known as Tannin albuminate is an antidiarrheal . Antidiarrheals, intestinal anti inflammatory anti infective agents Category Antidiarrhoeals gastrointestinal drug stub ja ... more details
orphan date November 2007 Radioiodinated serum albumin , abbreviated RISA, is a marker used in identifying blood plasma via the dilution method in renal physiology . Category Renal physiology Category Iodine medicine stub ... more details
protein name albumin caption Protein Data Bank PDB rendering based on 1e7h. image ALB structure.png width ... 1E7H ECnumber Chromosome 4 Arm q Band 13.3 LocusSupplementaryData Human serum albumin is the most abundant protein in human blood plasma . It is produced in the liver . Albumin constitutes about half of the blood serum protein. It is soluble and monomeric. Albumin transports hormones, fatty acids, and other compounds, buffers pH, and maintains osmotic pressure, among other functions. Albumin is synthesized ... cleaved in the Golgi vesicles to produce the secreted albumin. The reference range for albumin concentrations ... article 003480.htm title Albumin serum MedlinePlus Medical Encyclopedia publisher Nlm.nih.gov date ... mass of 67 kDa. The gene for albumin is located on chromosome 4 and mutations in this gene can result in anomalous proteins. The human albumin gene is 16,961 nucleotides long from the putative cap site ... Transports many medication drugs serum albumin levels can affect the half life of drugs Competitively binds calcium ions Ca sup 2 sup Buffers pH Serum albumin, as a negative acute phase protein ... albumin is a component of liver function tests LFTs , but may be ordered separately. Albumin can ... Reference ranges for blood tests , comparing blood content of albumin shown in purple at right with other constituents. Pathology Hypoalbuminemia Low blood albumin levels hypoalbuminemia can be caused ... , and albumin is known to increase cellular taurine absorption. Zinc has been shown to increase retinol vitamin A production from beta carotene, and in lab experiments retinol reduced human albumin ... I, Watanabe T, Suzuki T title All trans retinoic acid down regulates human albumin gene expression ... vitamin A deficiency alone could cause albumin levels to become raised. Patients recovering from ... 2006 month June pmid 16716979 doi 10.1080 00365520500442625 url ref Therapeutic Uses Human albumin solution or HAS is available for medical use, usually at concentrations of 5 25 . Human albumin is often ... more details
About albumin specific to cows the human variant human serum albumin the family of mammalian albumins serum albumin Infobox nonhuman protein Name albumin image Bovine serum albumin 3v03 crystal structure.jpg width caption Organism Bos taurus domestic cow TaxID 9913 Symbol ALB AltSymbols CAS number CAS supplemental EntrezGene 280717 PDB RefSeqmRNA NM 180992 RefSeqProtein NP 851335 UniProt P02769 ECnumber Chromosome 6 EntrezChromosome NC 007304 GenLoc start 91543999 GenLoc end 91567876 Bovine serum albumin also known as BSA or Fraction V is a serum albumin protein derived from cows. It is often used as a protein concentration standard. The nickname Fraction V refers to albumin being the fifth fraction of the original Cohn process Edwin Cohn purification methodology that made use of differential solubility characteristics of plasma protein s. By manipulating solvent concentrations, pH, salt levels, and temperature , Cohn was able to pull out successive fractions of blood plasma . The process was first commercialized with human albumin for medical use and later adopted for production of BSA. Properties The full length BSA precursor protein is 607 amino acids in length. An N terminus N terminal 18 residue signal peptide is cut off from the precursor protein upon secretion, hence the initial protein product contains 589 amino acid residues. An additional 4 amino acids is cleaved to yield ... AK, Thompson MR title Hydrodynamic structure of bovine serum albumin determined by transient electric ... of the cattle industry. See also Acceptable daily intake Protein allergy Human serum albumin Serum albumin ... b430384deb613141a202 title Bovine Serum Albumin 7 Solution author Wise SA, Watters RL date 2010 06 30 ... Rapid confirmation and revision of the primary structure of bovine serum albumin by ESIMS and Frit .....pdf issn refend External links MeshName Serum Albumin, Bovine DEFAULTSORT Bovine Serum Albumin Category Proteins cs Hov z s rov albumin es Alb mina de suero bovino fr Albumine de s rum bovin nl ... more details
Diagnostic infobox Name CSF serum albumin ratio Image Alt Caption DiseasesDB ICD10 ICD9 ICDO MedlinePlus eMedicine MeshID LOINC LOINC 1756 6 HCPCSlevel2 Reference range CSF serum albumin ratio is a test performed to compare the levels of albumin in the cerebrospinal fluid and the Blood serum serum . It is useful as a measure of the integrity of the blood brain barrier . ref name pmid17531849 cite journal author Luque FA, Jaffe SL title Cerebrospinal fluid analysis in multiple sclerosis journal Int. Rev. Neurobiol. volume 79 issue pages 341 56 year 2007 pmid 17531849 doi 10.1016 S0074 7742 07 79015 3 url http linkinghub.elsevier.com retrieve pii S0074 7742 07 79015 3 series International Review of Neurobiology isbn 9780123737366 ref ref name pmid15932356 cite journal author Anckars ter H, Forsman A, Blennow K title Increased CSF serum albumin ratio a recurrent finding in violent offenders journal Acta Neurol. Scand. volume 112 issue 1 pages 48 50 year 2005 month July pmid 15932356 doi 10.1111 j.1600 0404.2005.00433.x url http www3.interscience.wiley.com resolve openurl?genre article&sid nlm pubmed&issn 0001 6314&date 2005&volume 112&issue 1&spage 48 ref ref name pmid17511849 cite journal author Algotsson A, Winblad B title The integrity of the blood brain barrier in Alzheimer s disease journal Acta Neurol. Scand. volume 115 issue 6 pages 403 8 year 2007 month June pmid 17511849 doi 10.1111 j.1600 0404.2007.00823.x url http www3.interscience.wiley.com resolve openurl?genre article&sid nlm pubmed&issn 0001 6314&date 2007&volume 115&issue 6&spage 403 ref References div style float right border solid 10px white Test sample values div Reflist Category Neurology Category CSF tests medicine stub CSF tests ... more details
Test sample values align right The serum ascites albumin gradient or gap SAAG is a calculation used in medicine to help determine the cause of ascites . ref name pmid18334692 cite journal author Wong CL, Holroyd Leduc J, Thorpe KE, Straus SE title Does this patient have bacterial peritonitis or portal hypertension? How do I perform a paracentesis and analyze the results? journal JAMA volume 299 issue 10 pages 1166 78 year 2008 month March pmid 18334692 doi 10.1001 jama.299.10.1166 url http jama.ama assn.org cgi pmidlookup?view long&pmid 18334692 ref The SAAG may be a better discriminant than the older method of classifying ascites fluid as a transudate versus exudate . ref name pmid1616215 cite journal author Runyon BA, Montano AA, Akriviadis EA, Antillon MR, Irving MA, McHutchison JG title The serum ascites albumin gradient is superior to the exudate transudate concept in the differential diagnosis of ascites journal Annals of Internal Medicine volume 117 issue 3 pages 215 20 year 1992 month August pmid 1616215 doi url ref The formula is as follows SAAG albumin concentration of Blood serum serum albumin concentration of ascitic fluid . Ideally, the two values should be measured at the same time. The reason for the value measurement is simple, using Starling s forces as a guide. If you think about it, when you have a small gap i.e. 1.1 then fluid wants to equilibrate due to oncotic pressures being similar. In conditions where there is a high gradient ie, 1.1 , the fluid SHOULD stay in the circulation because of the serum oncotic pressure trying to maintain it. Despite this desire, the ascites will still accumulate secondary to the hydrostatic pressure ie Budd Chiari, Heart Failure or Cirrhosis pushing the fluid into the abdomen. Differential High gradient A high gradient 1.1 g dL indicates the ascites is due to portal hypertension with 97 accuracy. ref name pmid1616215 ... , which in turn forces water out into the peritoneal cavity but leaves proteins such as albumin within ... more details
orphan date March 2010 The surfactant albumin ratio is a test for assessing Fetus fetal lung maturity. ref name pmid10920328 cite journal author Liu KZ, Shaw RA, Dembinski TC, Reid GJ, Ying SL, Mantsch HH title Comparison of infrared spectroscopic and fluorescence depolarization assays for fetal lung maturity journal Am. J. Obstet. Gynecol. volume 183 issue 1 pages 181 7 year 2000 month July pmid 10920328 doi 10.1067 mob.2000.105345 url http linkinghub.elsevier.com retrieve pii S0002 9378 00 77338 8 ref References reflist Obstetrical procedures Category Embryology medicine stub ... more details
No less than 90 of the radioactivity present in the product must be tagged to albumin particles ... study is 3 4 mCi containing between 100,000 250,000 albumin particles . The particle burden should ... more details
wiktionary albumen albumin Albumen is the white of an egg. It contains albumin proteins. Albumin is a class of several hundred proteins. Albumen or Albumin may also refer to Serum albumin , a protein, encoded by the ALB gene in humans Operation Albumen , a series of sabotages against airfields on occupied Crete in 1942 Albumen album Albumen album , by The Egg See also Human serum albumin the human variant Bovine serum albumin the cow variant Endosperm , tissue produced in the seeds of most flowering plants Albumen print , method of producing a print on a paper base from a negative using egg white lookfrom Albumen intitle Albumen lookfrom Albumin intitle Albumin disambiguation title Albumen ... more details
Analbuminaemia or analbuminemia is a genetically inherited metabolism metabolic defect characterised by an impaired synthesis of human serum albumin serum albumin . ref cite journal author Watkins S, Madison J, Galliano M, Minchiotti L, Putnam FW title Analbuminemia three cases resulting from different point mutations in the albumin gene journal Proc. Natl. Acad. Sci. U.S.A. volume 91 issue 20 pages 9417 21 year 1994 pmid 7937781 doi 10.1073 pnas.91.20.9417 pmc 44823 ref Despite the fact that albumin is the most common serum protein, analbuminaemia is a benign condition. References references Category Inborn errors of metabolism Category Albumin disorders pathology stub pl Analbuminemia ... more details
orphan date April 2009 Bisalbuminemia is the, sometimes inherited, condition of having two types of serum albumin that differ in mobility during electrophoresis . It can be seen in densitometry as a bifid mountain where albumin has 2 heads. Inherited bisalbuminemia has no pathologic effects, but is of interest to researchers who study the evolution and functional changes in the protein. ref http www.clinchem.org cgi content full 48 11 2076 ref References Reflist Category Albumin disorders ... more details
SAAG can mean South Asia Analysis Group , a non profit thinktank concerned with South Asian affairs. serum ascites albumin gradient See also Saag , an Indian foodstuff disambig ... more details
Orphan date February 2009 In medicine and pharmacology, albondin is a cell receptor that binds albumin . References cite pmid 8119952 Category Receptors pharma stub ... more details
Infobox disease Name Hypoalbuminemia Image Caption DiseasesDB 31324 ICD10 ICD9 ICD9 273.8 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 1116 MeshID D034141 Hypoalbuminemia is a medical condition where levels of human serum albumin albumin in blood serum are abnormally low. It is a specific form of hypoproteinemia . Albumin is a major protein in the human body, making up about 60 of total human Blood plasma plasma protein by mass. Many hormone s, drug s, and other molecules are mostly bound to albumin in the bloodstream and must be released before becoming biologically active. For example, calcium binds to albumin and hypoalbuminemia leads to an increase in free ionized calcium. Albumin is synthesized in the liver , and low serum albumin may be indicative of liver failure or diseases such as cirrhosis or chronic hepatitis . Hypoalbuminemia can also present as part of the nephrotic syndrome , in which protein is lost in the urine due to kidney damage. Low albumin levels can be an indicator of chronic malnutrition or protein losing enteropathy . Hypoalbuminemia may cause generalized edema swelling via a decrease in oncotic pressure . The serum albumin level is part of a standard panel of liver function tests . Levels below 3.5 grams per deciliter are generally considered low External links CrispThesaurus 00004012 http www.medscape.com viewarticle 484802 Treating Hypoalbuminemia In Critically Ill Patients Abnormal clinical and laboratory findings for blood Category Abnormal clinical and laboratory findings for blood disease stub ca Hipoalbumin mia de Hypalbumin mie es Hipoalbuminemia id Hipoalbuminemia ja pl Hipoalbuminemia pt Hipoalbuminemia ru ... more details
Jeanatope is iodinated I 125 human serum albumin , typically injected to aid in the determination of total blood and blood plasma plasma volume . I 125 is a radioactive isotope of Iodine , it decays by electron capture with a physical half life of 60.14 days. The biologic half life in normal individuals for I 125 has been reported to be approximately 14 days. Iodinated I 131 albumin Volumex, Daxor is used for a similar purpose. External links http www.isotexdiagnostics.com jeanatope i 125.html Jeanatope at isotexdiagnostics.com Category Iodine pharma stub ... more details
Thyroxine binding proteins is a protein which binds thyroid hormone . Examples include Thyroxine binding globulin Transthyretin Serum albumin External links MeshName Thyroxine binding proteins Glycoproteins Biochem stub Category Human proteins Category Blood proteins ... more details
A tannate is the salt or ester of tannic acid . ref http medical dictionary.thefreedictionary.com tannate Medical Dictionary definition ref Albumin tannate also known as Tannin albuminate is an antidiarrheal. References reflist hydrolysable tannin Category Hydrolysable tannins polyphenol stub ... more details
and host specificity due to their varied affinities for different species of albumin. ref name ..., and stability variation in bacterial albumin binding modules implications for species specificity ... T, Wikstrom M title The GA module, a mobile albumin binding bacterial domain, adopts a three helix ... more details
Refimprove date November 2008 Pediatric end stage liver disease PELD is a disease severity scoring system for children under 12 years of age. It is calculated from the patient s human serum albumin albumin , bilirubin , and international normalized ratio INR together with the patient s age and degree of growth failure . This score is also used by the United Network for Organ Sharing UNOS for prioritizing allocation of Liver transplantation liver transplants . Determination PELD uses the patient s values for serum bilirubin , serum albumin , the Prothrombin time international normalized ratio for prothrombin time INR , whether the patient is less than 1 year old, and whether the patient has growth failure 2 standard deviation to predict survival. It is calculated according to the following formula ref http www.unos.org SharedContentDocuments MELD PELD Calculator Documentation.pdf ref PELD 4.80 Ln serum bilirubin mg dL 18.57 Ln INR 6.87 Ln albumin g dL 4.36 1 year old 6.67 growth failure See also Liver transplantation Model for end stage liver disease MELD References Reflist http www.unos.org United Network for Organ Sharing External links http www.unos.org resources MeldPeldCalculator.asp?index 99 PELD Calculator Category Diseases of liver Category Medical scoring system med stub ... more details
Unreferenced stub auto yes date December 2009 Orphan date November 2006 Riboflavin carrier proteins RFCPs together with human serum albumin transport flavin mononucleotide FMN in the Circulatory system blood circuit . RFCPs are important in pregnancy . DEFAULTSORT Riboflavin Carrier Protein Category Hematology Biochem stub ... more details
Lactalbumin is the albumins albumin contained in milk and obtained from whey . Lactalbumin is found in the milk of many mammals. There are Alpha lactalbumin alpha and beta lactalbumins both contained in milk. See also Alpha lactalbumin Beta lactoglobulin External links MeshName Lactalbumin Albumins Category Milk protein stub de Lactalbumin ... more details
DBP may refer to Dewan Bahasa dan Pustaka , a government body responsible for coordinating the use of the Malay language in Malaysia and Brunei German Farmers Party Deutsche Bauernpartei , former German political party Deutsche Bundespost , former German federal post office Development Bank of the Philippines Dibutyl phthalate , a plasticizer Disinfection by product , a chemical occurring in water as a result of disinfection in medicine , Diastolic blood pressure A gene coding for the DBP gene D site of albumin promoter albumin D box binding protein Disambig de DBP es DBP it DBP pl DBP ... more details
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