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Anti Basment Membrane Collagen Type IV Protein
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Encyclopedia results for Anti Basment Membrane Collagen Type IV Protein

Anti Basment Membrane Collagen Type IV Protein





Encyclopedia results for Anti Basment Membrane Collagen Type IV Protein

  1. Type-IV collagen

    Type IV collagen is a type of collagen found primarily in the basal lamina . The type IV collagen C4 domain at the C terminus is not removed in post translational processing, and the fibers link head to head, rather than in parallel. Also, type IV lacks the regular glycine in every third residue necessary for the tight, collagen helix . This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina There are six human genes associated with it ref name pmid18219669 cite journal author Khoshnoodi J, Pedchenko V, Hudson BG title Mammalian collagen IV journal Microsc. Res. Tech. volume 71 issue 5 pages 357 70 year 2008 month May pmid 18219669 doi 10.1002 jemt.20564 ref COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 Clinical significance The alpha 3 protein constituent of type IV collagen is thought to be the antigen implicated in Goodpasture s syndrome , wherein the immune system attacks the basement membrane s of the glomerulus glomeruli and the alveolus alveoli . Mutations to the genes coding for type IV collagen lead to Alport syndrome . References Reflist External links MeshName Collagen type IV Category Collagens Fibrous proteins protein stub ...   more details



  1. Collagen, type IV, alpha 1

    primary structure of the alpha 1 chain of human basement membrane type IV collagen journal FEBS ..., a heparin binding bone morphogenetic protein, with type IV collagen. journal J. Biol. Chem ... complex to basement membrane collagen type IV. journal Eur. J. Biochem. volume 184 issue 1 pages ... domain of basement membrane type IV collagen. journal Eur. J. Biochem. volume 176 issue 3 pages 617 ... of the alpha 1 chain of human basement membrane collagen type IV reveals 21 non triplet interruptions ...PBB geneid 1282 Collagen alpha 1 IV chain is a protein that in humans is encoded by the COL4A1 gene . ref ... the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head to head conformation with another type IV collagen gene so that each gene pair shares a common promoter. ref name entrez cite web title Entrez Gene COL4A1 collagen, type IV, alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... type IV collagen genes. journal Ann. N. Y. Acad. Sci. volume 580 issue pages 97 111 year 1990 pmid ... of fibronectin and vitronectin receptors and collagen type IV. journal J. Leukoc. Biol. volume 51 ... of human type IV collagen. journal J. Biol. Chem. volume 264 issue 23 pages 13565 71 year 1989 pmid ... R, K hn K title The genes for the alpha 1 IV and alpha 2 IV chains of human basement membrane collagen type IV are arranged head to head and separated by a bidirectional promoter of unique structure ... of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter ... T, Tryggvason K, Myers JC, et al. title cDNA clones coding for the pro alpha1 IV chain of human type ... 1 type IV and other procollagen chains. journal Proc. Natl. Acad. Sci. U.S.A. volume 82 issue 11 ... author Bowcock AM, Hebert JM, Christiano AM, et al. title The pro alpha 1 IV collagen gene is linked ..., III, and IV collagen a dispersed gene family. journal Proc. Natl. Acad. Sci. U.S.A. volume 82 issue ...   more details



  1. Type IV collagen C4 domain

    P, Hudson BG title Crystal structure of NC1 domains. Structural basis for type IV collagen assembly ... fold s into a protein tertiary structure tertiary structure with predominantly beta strands. The collagen IV C4 domain is composed of two similarly protein folding folded subdomains stabilised ... P, Hudson BG title Crystal structure of NC1 domains. Structural basis for type IV collagen assembly ...Infobox protein family Symbol C4 Name C4 image PDB 1li1 EBI.jpg width caption the 1.9 a crystal structure of the noncollagenous nc1 domain of human placenta collagen iv shows stabilization via a novel type of covalent met lys cross link Pfam PF01413 Pfam clan CL0056 InterPro IPR001442 SMART C4 PROSITE PDOC00031 MEROPS C47 SCOP 1hra TCDB 2.A.16 OPM family OPM protein CAZy CDD In molecular biology, the type IV collagen C4 domain or collagen IV NC1 domain is a duplicated protein domain domain present at the C terminus of type IV collagen s. Each type IV collagen contains a long triple helical collagenous domain flanked by a short 7S domain of 25 amino acids and a globular non collagenous C4 domain ... W title The 1.9 A crystal structure of the noncollagenous NC1 domain of human placenta collagen IV shows stabilization via a novel type of covalent Met Lys cross link journal Proc. Natl. Acad. Sci ... network of collagen IV. Reinforced stabilization of the noncollagenous domain 1 by noncovalent forces ... 30 year 2004 month October pmid 15299013 doi 10.1074 jbc.M406344200 url ref The collagen IV C4 domain ... HD, Bode W title The 1.9 A crystal structure of the noncollagenous NC1 domain of human placenta collagen IV shows stabilization via a novel type of covalent Met Lys cross link journal Proc. Natl. Acad ... network of collagen IV. Reinforced stabilization of the noncollagenous domain 1 by noncovalent ... chains interact, forming an C4 trimer, to select and register chains for Collagen helix triple ... InterPro content IPR001442 Category Protein domains ...   more details



  1. Membrane protein

    of the lipid bilayer are indicated by red and blue dots. A membrane protein is a protein molecule .... Membrane transport protein Transport protein s play an important role in the maintenance of concentrations ... bilayer or with integral membrane proteins Lipid anchored protein s bound to lipid bilayer bound .... Integral membrane proteins Integral membrane protein s are permanently attached to the membrane. They can ... proteins with known 3D structure to different membrane types ref Membrane protein complexes Membrane ... their function and regulation. Reoccurring in recent literature are the ideas that membrane protein ..., and membrane proteins can be interchanged in existing complexes. Membrane protein complexes ... preventing damaging interactions they could cause. Membrane protein complexes are not fixed entities ..., 18 420 424. ref Assembly of membrane protein There are two different types of membrane proteins depending upon the synthesis it undergoes and they are Constitutive membrane protein and non constitutive membrane protein. Constitutive membrane protein The messengerRNA attaches to the translocon which ... in the bilayer membrane. When the protein is left in the membrane bilayer more protein folding occurs creating its final 3D structure White . Non constitutive membrane protein Examples of non ... Principle of Membrane Protein Folding and Stability. Stephen White Laboratory Homepage. 10 Nov. 2009. web. ref Membrane protein structures In membrane proteins the two known structural classes of membrane ... environment. The influence of the environment on membrane protein structures is especially ... has been particularly challenging as shown by the low number of membrane protein structures determined ... for existing structural methodologies. Many of the successful membrane protein structures are characterized ... conditions that can be chosen for crystallization and for solution NMR. All membrane protein ... of Solubilizing Environments on Membrane Protein Structures ref See also Integral membrane protein ...   more details



  1. Collagen alpha-3(IV) chain

    membrane collagen type IV. journal Immunology volume 47 issue 1 pages 133 40 year 1982 pmid 6811420 ... membrane proteins in normal and fibrotic human liver collagen type IV, laminin, and fibronectin ...PBB geneid 1285 Collagen alpha 3 IV chain is a protein that in humans is encoded by the COL4A3 gene . ref ... of type IV collagen journal J Clin Invest volume 89 issue 2 pages 592 601 year 1992 month Mar pmid ... region. Like the other members of the type IV collagen gene family, this gene is organized in a head to head conformation with another type IV collagen gene so that each gene pair shares a common promoter ... strand. ref name ncbi cite web title Entrez Gene COL4A3 collagen, type IV, alpha 3 Goodpasture ... Pescucci C, Longo I, Bruttini M, et al. title Type IV collagen related diseases. journal J. Nephrol ... B, Ars E, Ballar n J title Collagen type IV alpha3 alpha4 nephropathy from isolated haematuria to renal ... and collagen type IV. journal J. Leukoc. Biol. volume 51 issue 6 pages 546 56 year 1992 pmid ... Sequence and localization of a partial cDNA encoding the human alpha 3 chain of type IV collagen ... encoding basement membrane alpha 1 IV and alpha 2 IV chains map to the distal long arm of chromosome ... in cartilage. Specific interaction of fibronectin with collagen type II. journal Histochemistry ... maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome , autoantibodies bind to the collagen ... are localized largely to the non collagenous C terminal domain of the protein. A specific ... author Hinek A title Nature and the multiple functions of the 67 kD elastin laminin binding protein ...   more details



  1. Type-I collagen

    protein Name collagen, type I, alpha 1 caption image width HGNCid 2197 Symbol COL1A1 AltSymbols EntrezGene 1277 OMIM 120150 RefSeq NM 000088 UniProt P02452 PDB ECnumber Chromosome 17 Arm q Band 21.3 LocusSupplementaryData q22 protein Name collagen, type I, alpha 2 caption image width HGNCid 2198 Symbol COL1A2 AltSymbols OI4 EntrezGene 1278 OMIM 120160 RefSeq NM 000089 UniProt P08123 PDB ECnumber Chromosome 7 Arm q Band 21.3 22.1 LocusSupplementaryData Type I collagen is the most abundant collagen of the human body. It is present in scar tissue , the end product when tissue healing heals by repair. It is found in tendon s, the endomysium of myofibrils and the organic part of bone . See also Collagen Type II collagen Collagen, type III, alpha 1 COL1A1 COL1A2 External links MeshName Collagen type I Fibrous proteins Category Collagens gene 17 stub ca Col lagen tipus I ...   more details



  1. Type XVIII collagen

    protein Name collagen, type XVIII, alpha 1 caption image width HGNCid 2195 Symbol COL18A1 AltSymbols EntrezGene 80781 OMIM 120328 RefSeq NM 130445 UniProt P39060 PDB ECnumber Chromosome 21 Arm q Band 22.3 LocusSupplementaryData Type XVIII collagen is a type of collagen which can be cleaved to form endostatin . File Schematic representation of the human collagen XVIII variants.jpg thumb 640px Schematic representation of the human collagen XVIII variants External links MeshName Collagen Type XVIII Category Collagens biochem stub Fibrous proteins ca Col lagen tipus XVIII ...   more details



  1. Type-V collagen

    Type V collagen is a form of fibrillar ref cite journal author Wenstrup RJ, Florer JB, Brunskill EW, Bell SM, Chervoneva I, Birk DE title Type V collagen controls the initiation of collagen fibril assembly journal J. Biol. Chem. volume 279 issue 51 pages 53331 7 year 2004 pmid 15383546 doi 10.1074 jbc.M409622200 ref collagen associated with classical Ehlers Danlos syndrome . Genes COL5A1 , COL5A2 , COL5A3 References references External links MeshName Collagen Type V Fibrous proteins Category Collagens protein stub ca Col lagen tipus V ...   more details



  1. Type-II collagen

    protein Name collagen, type II, alpha 1 primary osteoarthritis, spondyloepiphyseal dysplasia, congenital caption image width HGNCid 2200 Symbol COL2A1 AltSymbols SEDC EntrezGene 1280 OMIM 120140 RefSeq NM 001844 UniProt P02458 PDB ECnumber Chromosome 12 Arm q Band 13.11 LocusSupplementaryData q13.2 Type II collagen is the basis for articular cartilage and hyaline cartilage . It makes up 50 of all protein in cartilage and 85 90 of collagen of articular cartilage. Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue. Treatment of Rheumatoid Arthritis According to a study ref Cite journal last Trentham first D. last2 Dynesius Trentham first2 R. last3 Orav first3 J. last4 Combitchi first4 D. last5 Lorenzo first5 C. last6 Sewell first6 K. last7 Hafler first7 D. lastauthoramp yes first8 H. last8 Weiner title Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis journal Science journal Science year 1993 volume 261 issue 5119 pages 1727 1730 doi 10.1126 science.8378772 ref published in the journal Science, oral administration of type II collagen improves symptoms of rheumatoid arthritis . The authors conducted a randomized, double blind trial involving 60 patients with severe, active rheumatoid arthritis. A decrease in the number of swollen joints and tender joints occurred in subjects fed with chicken type II collagen for 3 months, but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident. References Reflist colwidth 30em See also Collagen Type I collagen Collagen, type III, alpha 1 External links MeshName Collagen type II gene 12 stub Fibrous proteins Category Collagens ...   more details



  1. Type XXVII collagen

    Unreferenced date December 2009 Orphan date December 2009 Type XXVII collagen is the protein predicted to be encoded by COL27A1 . It was first described by Dr. James M. Pace and his colleagues at the University of Washington . It is related to the fibrillar collagens type II, type XI, and type XXIV. Current research suggests that it is made by cartilage during skeletal development. DEFAULTSORT Type Xxvii Collagen Category Proteins ...   more details



  1. Membrane fusion protein

    Membrane fusion proteins are membrane proteins which cause more than one membrane to combine. Examples include SNARE protein , such as Vesicle associated membrane protein VAMP Gp41 See also Fusion protein Interbilayer Forces in Membrane Fusion External links MeshName Membrane fusion proteins Membrane proteins Category Membrane proteins membrane protein stub ...   more details



  1. Eggshell and protein membrane separation

    Orphan date November 2011 wikify date November 2011 Eggshell and Protein Membrane Separation is a recycling ... the shells and the attached membrane attract vermin. Together the calcium carbonate eggshell and protein rich membrane have no value or use. ref name Wei Wei Z, Li B, Xu C Application of waste eggshell ... as a low cost catalyst for biodiesel production. ref name Wei Eggshell and Protein Membrane Separation ... method to separate the eggshell and Membrane protein protein membrane . The two products are processed in two streams to yield mm size particles of dry membrane and mm size particles of dried shell ... to separate the eggshell form the protein membrane. ref name Yoo Then the ground eggshell is placed ... the lighter component protein membrane to float and the heavier calcium carbonate eggshells to sink. This unit recovers 96 of eggshell membrane and 99 of eggshell calcium carbonate in two hours. ref ... a year. ref name Hecht Hecht J Eggshells break into collagen market. New Scientist 1999, 161 6 ... 2009, 100 2883 2885. ref The invention of an eggshell and membrane separator has allowed for the recycling .... ref name Vlad Vlad Eggshell membrane separation method. In US Patent, vol. 7534909. United States Biova, L.L.C 2009. ref Eggshell particles are used in toothpaste as an anti tartar agent. ref name Fermented ... State University developed a machine that uses a delicate multi bladed knife to scrape the membrane form the surface of shell fragments. ref MacNeil JH Method and apparatus for separating a protein membrane and shell material in waste egg shells In United States Patent Foundation TPSR ed., vol. 6,176,376 ... , and a light vacuum to separate the hard eggshell from the protein containing membranes. ref name Adams Adams Egghell membrane separation method. In US Patent 7,017,277, United States ESM Technologies ... a series of heated augers. Once the shell and membrane flakes reach the appropriate moisture ... eggshell flakes fromt the lighter membrane flakes. This invention has been commercialized and can ...   more details



  1. Integral membrane protein

    File transmembrane receptor.svg thumb right E extracellular space P plasma membrane I intracellular space An integral membrane protein IMP is a protein molecule or assembly of proteins that is permanently attached to the biological membrane . Proteins that cross the membrane are surrounded by annular lipids, which are defined as lipids that are in direct contact with a membrane protein. Such proteins ... in the Protein Data Bank . Their membrane anchoring helices have been removed to facilitate the extraction and Protein crystallization crystallization . Search http www.ebi.ac.uk pdbe srv PDBeXplore go ?GO go 0016021 integral membrane proteins in the PDB based on gene ontology classification ... monotopic protein s Integral Polytopic Protein Main Integral polytopic protein The most common type of IMP is the transmembrane protein TM , which spans the entire biological membrane . Single pass membrane ... protein structures and to develop techniques for use in structural biology , including for membrane ... Function IMPs include Membrane transport protein transporters , linkers, Ion channel channels , Receptor ... proteins Glycophorin Rhodopsin Band 3 CD36 GPR30 See also Membrane protein s Transmembrane protein s Peripheral membrane protein s Orientations of Proteins in Membranes database Hydrophilicity plot s Inner ... 7007 7 50 The Human Membrane Proteome A comprehensive article covering the transmembrane protein component ... laboratory Cell membranes DEFAULTSORT Integral Membrane Protein Category Membrane biology Category Integral membrane proteins Category Protein structure ar ca Prote na integral de ... wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms journal Protein Science volume 7 issue 4 pages 1029 38 year 1998 pmid 9568909 pmc 2143985 doi 10.1002 pro.5560070420 ref All transmembrane protein s are IMPs, but not all IMPs are transmembrane proteins ... integral membrane proteins are currently determined at atomic resolution by X ray crystallography ...   more details



  1. Peripheral membrane protein

    Peripheral membrane proteins are protein s that adhere only temporarily to the biological membrane with which they are associated. These molecules attach to integral membrane protein s, or penetrate the peripheral regions of the lipid bilayer . The regulatory protein subunits of many ion channel s and transmembrane receptor s, for example, may be defined as peripheral membrane proteins. In contrast to integral membrane proteins, peripheral membrane proteins tend to collect in the water soluble component ... of integral membrane protein s. The reversible attachment of proteins to biological membranes has .... In cite book author Tamm LK Editor title Protein Lipid Interactions From Membrane Domains to Cellular ... the probability of any appropriate protein protein interactions. Image Monotopic membrane protein.svg ... can be buried in a protein s hydrophobic binding pocket after dissociation from the membrane. This process ... protein interactions in cell signaling and membrane trafficking journal Annual Review of Biophysics ... lipid occurs via specific membrane targeting structural domains that occur within the protein and have ... lipid interaction between both protein C2 domain C2 type domains and annexin s. ref . Protein ... electrostatic interactions play an important role in Protein targeting membrane targeting of electron ... book last Sankaram first MB coauthors Marsh D title Protein lipid interactions with peripheral membrane ... ref chemical labeling, measurement of membrane binding affinities of protein ... title Positioning membrane proteins by novel protein engineering and biophysical approaches journal ...?PF03055 Pfam entry Retinal pigment epithelial membrane protein ref Carotenoids function in both plants ... cell s. See also Membrane protein s Lipoprotein s Transmembrane proteins Antimicrobial peptide s References ... title Protein Lipid Interactions From Membrane Domains to Cellular Networks url http books.google.com ... 3 oclc doi cite journal author Cho, W. and Stahelin, R.V. year 2005 title Membrane protein interactions ...   more details



  1. Collagen, type III, alpha 1

    books NBK1494 GeneReview NCBI NIH UW entry on Ehlers Danlos Syndrome Type IV MeshName Collagen type III gene 2 stub Fibrous proteins Category Collagens The PBB Controls template provides controls for Protein Box Bot, please see Template PBB Controls for details. PBB Controls update page yes require manual inspection no update protein box yes update summary no update citations yes ...PBB geneid 1281 Collagen alpha 1 III chain is a protein that in humans is encoded by the COL3A1 gene ref name pmid2780304 cite journal author Janeczko RA, Ramirez F title Nucleotide and amino acid sequences of the entire human alpha 1 III collagen journal Nucleic Acids Res volume 17 issue 16 pages 6742 year 1989 month Oct pmid 2780304 pmc 318382 doi 10.1093 nar 17.16.6742 ref ref name pmid2834369 cite ... type IV a multi exon deletion in one of the two COL3A1 alleles affecting structure, stability, and processing of type III procollagen journal J Biol Chem volume 263 issue 13 pages 6226 32 year 1988 month Jun pmid 2834369 pmc doi ref , which is located on chromosome 2 . Function Collagen alpha 1 III chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. Although alternate transcripts ..., often leading to the exclusion of multiple exons. ref cite web title Entrez Gene COL3A1 collagen, type III, alpha 1 Ehlers Danlos syndrome type IV, autosomal dominant url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1281 accessdate ref Type III collagen is a fibrous ... yields gelatin on boiling . Scleroprotein is a simple protein found in horny and cartilaginous tissues and in the lens of the eye . Clinical significance Mutations in this gene are associated with type III and IV Ehlers Danlos syndrome and with aortic and arterial aneurysm s. See also Collagen Reticular ... collagen type IX , and network forming collagen type X cause a spectrum of diseases of bone ...   more details



  1. Vesicle-associated membrane protein

    Vesicle associated membrane proteins VAMP are a family of SNARE protein SNARE proteins with similar structure, and are mostly involved in vesicle fusion . VAMP1 and VAMP2 proteins known as synaptobrevin s are expressed in brain and are constituents of the synaptic vesicles, where they participate in exocytosis neuromediator release . VAMP3 known as cellubrevin is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles. VAMP5 and VAMP7 SYBL1 participate in constitutive exocytosis. VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures. VAMP7 is found both in secretory granules and endosomes. VAMP8 known as endobrevin participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells. VAMP4 is involved in transport from the Golgi. ref cite journal author Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH title Vesicle associated membrane protein 4 is implicated in trans Golgi network vesicle trafficking journal Mol. Biol. Cell volume 10 issue 6 pages 1957 72 year 1999 pmid 10359608 doi pmc 25394 ref References references External links MeshName Vesicle Associated Membrane Protein 1 Membrane proteins Vesicular transport proteins Category Membrane proteins membrane protein stub ...   more details



  1. Membrane transport protein

    Refimprove date January 2009 A membrane transport protein or simply transporter is a membrane protein ref MeshName Membrane transport proteins ref involved in the movement of ion s, small molecule s, or macromolecule s, such as another protein across a biological membrane . Transport proteins are integral membrane protein s that is they exist within and span the membrane across which they transport substances. The proteins may assist in the movement of substances by facilitated diffusion or active transport . These mechanisms of action are known as carrier mediated transport . ref http www.answers.com topic carrier mediated transport Carrier mediated transport , Answers.com ref Types Image Scheme facilitated diffusion in cell membrane en.svg right thumb 400px Facilitated diffusion Grouped by Transporter Classification database categories 1 Channels Pores Facilitated diffusion 2 Electrochemical Potential driven transporters Mitochondrial membrane transport protein Glucose transporter Neurotransmitter transporter s Glutamate transporter Glutamate aspartate transporter s GABA transporter s Glycine transporter s Monoamine transporter s, including Dopamine transporter DAT Norepinephrine transporter NET Serotonin transporter SERT Vesicular monoamine transporter s VMAT Equilibrative nucleoside transporter Adenosine transporter s Vesicular acetylcholine transporter VAChT 3 Primary Active Transporters ATP binding cassette transporter genes P glycoprotein CD98 V ATPase Ion transporter s Na K ATPase Plasma membrane Ca2 ATPase Plasma membrane Ca sup 2 sup ATPase Proton pump Hydrogen potassium ... transport protein Wikipedia MeSH D12.776 MeSH D12.776.157.530 membrane transport proteins References reflist External links DorlandsDict seven 000087339 Transport protein Carrier proteins Ion channels Membrane transport proteins Neurotransmitter transporters ABC transporters Ion pumps Category Transport ... Systems 9.A.50 Karyopherin Ungrouped CD36 See also Carrier protein Co transport Cotransport Cotransporter ...   more details



  1. Outer membrane protein G

    Pfam box Symbol Porin OmpG Name Outer membrane protein G OmpG image 2iwv.gif width 220 caption Pfam PF09381 InterPro SMART Prosite SCOP 2iwv TCDB 1.B.21 OPM family 181 OPM protein 2iwv PDB Outer membrane protein G OmpG is a porin protein porin , a channel proteins in the Bacterial outer membrane outer membrane of Gram negative bacteria . Escherichia coli OmpG forms a 14 stranded beta barrel and in contrast to most porins, appears to function as a monomer. ref name pmid16797588 cite journal author Subbarao GV, van den Berg B title Crystal structure of the monomeric porin OmpG journal J. Mol. Biol. volume 360 issue 4 pages 750 9 year 2006 month July pmid 16797588 doi 10.1016 j.jmb.2006.05.045 url ref The central pore of OmpG is wider than other E. coli porins and it is speculated that it may form a non specific channel for the transport of larger oligosaccharide s. ref name pmid16797588 cite journal author Subbarao GV, van den Berg B title Crystal structure of the monomeric porin OmpG journal J. Mol. Biol. volume 360 issue 4 pages 750 9 year 2006 month July pmid 16797588 doi 10.1016 j.jmb.2006.05.045 url ref References reflist Category Protein domains Category Protein families Category Outer membrane proteins membrane protein stub InterPro content ...   more details



  1. Mitochondrial membrane transport protein

    Mitochondrial membrane transport proteins are protein s which exist in the plasma membrane membranes of mitochondria and which serve to transport ref MeshName Mitochondrial Membrane Transport Proteins ref molecule s and other factors such as ion s into or out of the organelles. Examples Examples of mitochondrial transport protein s include the following The mitochondrial permeability transition mitochondrial permeability transition pore , which opens in response to increased mitochondrial calcium Ca sup 2 sup load and oxidative stress ref name Crompton Crompton M. 1999. http www.biochemj.org bj 341 0233 bj3410233.htm The mitochondrial permeability transition pore and its role in cell death . Biochemical Journal . Volume 341, Pages 233 249. PMID 10393078. Retrieved on January 23, 2007. ref The mitochondrial calcium uniporter which transports calcium in biology calcium from the cytosol of the Cell biology cell into the mitochondrial matrix ref name Crompton ref name Nicholls Nicholls DG. 2005. Mitochondria and calcium signaling. Cell Calcium , Volume 38, Issues 3 4, Pages 311 317. PMID 16087232. Retrieved on January 23, 2007. ref The mitochondrial sodium calcium exchanger , which carries Ca sup 2 sup ions out of the matrix in exchange for sodium Na sup sup ions. These transport proteins serve to maintain the proper electrochemical gradient electrical and chemical gradient s in mitochondria by keeping ions and other factors in the right balance between the inside and outside of mitochondria. See also Mitochondrial carrier Membrane transport protein References references Membrane transport proteins Mitochondrial proteins Category Transport proteins Category mitochondria Category transmembrane proteins membrane protein stub zh ...   more details



  1. Outer membrane protein OpcA

    Pfam box Symbol OpcA Name Outer membrane protein OpcA image 1k24.gif width 200 caption Pfam PF07239 InterPro IPR009876 SMART Prosite SCOP 1k24 TCDB OPM family 27 OPM protein 1k24 PDB PDB3 1k24 A 2 245 Outer membrane adhesin OpcA protein family consists of several Neisseria species specific outer membrane proteins. Neisseria meningitidis causes meningococcal meningitis and septicemia . Opc formerly called 5C is one of the major outer membrane proteins and has been shown to play an important role in meningococcal adhesion and invasion of epithelial and endothelial cells, mediating attachment to host cells by binding proteoglycan cell surface receptor s ref name PUB00013057 cite journal author Zhu P, Klutch MJ, Derrick JP, Prince SM, Tsang RS, Tsai CM title Identification of opcA gene in Neisseria polysaccharea interspecies diversity of Opc protein family journal Gene volume 307 issue pages 31 40 year 2003 pmid 12706886 doi 10.1016 S0378 1119 02 01208 8 ref . OpcA forms a 10 stranded beta barrel with five highly mobile extracellular loops that protrude above the surface of the membrane ref name PUB00028792 cite journal author Derrick JP, Prince SM, Achtman M title Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 6 pages 3417 21 year 2002 pmid 11891340 doi 10.1073 pnas.062630899 pmc 122538 ref . These extracellular loops combine to form a crevice in the external surface that is lined by positively charged residues, which is predicted to be a binding site for proteoglycan polysaccharides involved in pathogenesis. Conformational changes in the extracellular loops modulate the surface of OpcA ... . These conformational changes could also lead to pore opening. References reflist Category Protein domains Category Protein families Category Outer membrane proteins InterPro content IPR009876 ..., Derrick JP, Bond PJ title Membrane Simulations of OpcA Gating in the Loops? journal Biophys. J. volume ...   more details



  1. Collagen, type I, alpha 1

    collagen molecule and prevent the production of mature type I collagen, which results in type IV osteogenesis ...PBB geneid 1277 Collagen, type I, alpha 1 , also known as COL1A1 , is a human gene that encodes the major component of type I collagen , the fibrillar collagen found in most connective tissue s, including cartilage . Collagen is a protein that strengthens and supports many tissues in the body, including ... gene produces a component of type I collagen , called the pro alpha1 I chain. This chain combines ... result in the formation of very strong mature type I collagen fibers. The COL1A1 gene is located ... of type I collagen is compromised. Tissues that are rich in type I collagen, such as the skin .... The altered protein interacts abnormally with other collagen building proteins, disrupting the structure of type I collagen fibrils and trapping collagen in the cell. Researchers believe that these changes ... type I. The mutated copy of the gene does not produce any pro alpha1 I collagen chains. Because ... with this disorder make only half of the normal amount of type I collagen, which results in bone fragility ... prevent the normal production of mature type I collagen, which results in this severe condition ... chains. Type I collagen production is inhibited by the inability of the altered procollagen strands ... negatively affect tissues that are rich in type I collagen, such as the skin, bones, teeth, and tendons ... Osteogenesis imperfecta, type IV Several different types of mutations in the COL1A1 gene cause osteogenesis imperfecta type IV. These mutations may involve missing pieces of the COL1A1 gene or changes ... author Karsenty G, Park RW title Regulation of type I collagen genes expression journal Int Rev Immunol ... of polymorphism at the type I collagen COL1A1 locus with reduced bone mineral density, increased ... Danlos syndrome caused by a mutation in type I collagen journal Am J Hum Genet year 2000 pages 1398 ... associated collagen type IX , and network forming collagen type X cause a spectrum of diseases of bone ...   more details



  1. Collagen, type XIII, alpha 1

    PBB geneid 1305 Collagen alpha 1 XIII chain is a protein that in humans is encoded by the COL13A1 gene . ref name entrez The PBB Summary template is automatically maintained by Protein Box Bot. See Template ... matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer it is not known whether this trimer ... has not been determined. ref name entrez cite web title Entrez Gene COL13A1 collagen, type XIII, alpha ... 1 chain of type XIII collagen consists of three collagenous and four noncollagenous domains, and its ... P, et al. title Gene structure for the alpha 1 chain of a human short chain collagen type XIII with alternatively ... M, Pihlajaniemi T, Autio Harmainen H title Location and alternative splicing of type XIII collagen ... pmid 8246446 doi cite journal author H gg P, Rehn M, Huhtala P, et al. title Type XIII collagen is identified as a plasma membrane protein. journal J. Biol. Chem. volume 273 issue 25 pages 15590 7 year ... 2 beta 1 integrins. Alpha 1 beta 1 mediates cell adhesion to type XIII collagen. journal J. Biol ... journal author Sandberg Lall M, H gg PO, Wahlstr m I, Pihlajaniemi T title Type XIII collagen is widely ... Type XIII collagen and some other transmembrane collagens contain two separate coiled coil motifs, which ... 1 XIII collagen transcripts in HT 1080 cells and calvarial tissue resulted in identification of two ... 1 XIII collagen chain in human tissues and cell lines. journal J. Biol. Chem. volume 267 issue 34 pages ... K title Human alpha 1 XIII collagen gene. Multiple forms of the gene transcripts are generated ... collagen alpha 1 XIII chain gene COL13A1 to the q22 region of chromosome 10. journal Genomics ... weight human collagen that undergoes alternative splicing. journal Proc. Natl. Acad. Sci. U.S.A. ... M, et al. title Complete exon intron organization and chromosomal location of the gene for mouse type ...   more details



  1. Collagen, type XV, alpha 1

    PBB geneid 1306 Collagen alpha 1 XV chain is a protein that in humans is encoded by the COL15A1 gene ..., Pihlajaniemi T, Myers JC title Chromosomal assignment of a gene encoding a new collagen type COL15A1 ... 10.1016 S0888 7543 05 80209 5 ref ref name entrez cite web title Entrez Gene COL15A1 collagen, type ... chain of type XV collagen, a member of the FACIT collagen family fibril associated collagens with interrupted helices . Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle ... S, Hein m ki P, Rehn M, et al. title Primary structure of the alpha 1 chain of human type XV collagen ... AS, Abraham V, Amenta PS title Type XV collagen exhibits a widespread distribution in human tissues but a distinct localization in basement membrane zones. journal Cell Tissue Res. volume 286 issue ... PO, Peltonen S, et al. title Location of type XV collagen in human tissues and its accumulation in the interstitial ... exon intron organization of the human gene for the alpha1 chain of type XV collagen COL15A1 and comparison ... 10049780 doi 10.1006 bbrc.1999.0248 cite journal author Li D, Clark CC, Myers JC title Basement membrane zone type XV collagen is a disulfide bonded chondroitin sulfate proteoglycan in human tissues ... L, Muona A, Li tard J, Pihlajaniemi T title Structure of the mouse type XV collagen gene, Col15a1 ... accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template ... of a previously unknown human collagen chain, alpha 1 XV , characterized by extensive interruptions ... Y, et al. title The human alpha 1 XV collagen chain contains a large amino terminal non triple helical domain with a tandem repeat structure and homology to alpha 1 XVIII collagen. journal J. Biol ..., Volk R, et al. title Antiangiogenic activity of restin, NC10 domain of human collagen XV comparison ...   more details



  1. Collagen, type VI, alpha 1

    s003359900436 cite journal author Kuo HJ, Maslen CL, Keene DR, Glanville RW title Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen. journal J. Biol. Chem. volume ...PBB geneid 1291 Collagen alpha 1 VI chain is a protein that in humans is encoded by the COL6A1 gene . ref name entrez cite web title Entrez Gene COL6A1 collagen, type VI, alpha 1 url http www.ncbi.nlm.nih.gov ... Collagen type VI and related disorders Bethlem myopathy and Ullrich scleroatonic muscular dystrophy ... decorin to collagen type VI. journal J. Biol. Chem. volume 267 issue 8 pages 5250 6 ... of alpha 1 VI and alpha 2 VI chains of human type VI collagen reveals internal triplication of globular ... of the triple helical domain of human collagen type VI. journal J. Biol. Chem. volume 263 issue 35 ... Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen ... chains of collagen type VI by peptide sequences and cDNA clones. journal Eur. J. Biochem. volume 168 ... of alpha 1 VI and alpha 2 VI chains of human collagen type VI. journal Eur. J. Biochem. volume ... al. title Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures ... element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1 VI , alpha2 VI , and alpha3 VI chains. The alpha2 VI and alpha3 VI chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen alpha1 VI chain . Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. ref ... ejpn.2002.0593 cite journal author Lampe AK, Bushby KM title Collagen VI related muscle disorders ... organization of the triple helical coding regions of the human alpha 1 VI and alpha 2 VI collagen genes ... of bovine and human short chain collagen intima collagen . journal Eur. J. Biochem. volume 133 issue ...   more details



  1. Collagen, type XII, alpha 1

    PBB geneid 1303 Collagen alpha 1 XII chain is a protein that in humans is encoded by the COL12A1 gene ... Entrez Gene COL12A1 collagen, type XII, alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... of type XII collagen in embryonic tissues. journal J. Cell Biol. volume 109 issue 2 pages ..., Gerecke DR, Olsen BR title Type XII collagen distinct extracellular matrix component discovered by cDNA ... Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices journal ..., Keene DR, Tufa SF, et al. title Developmental distribution of collagen type XII in cartilage association ... DL, Champliaud MF, Olsen BR, Burgeson RE title Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1 XII collagen COL12A1 , alpha 1 IX collagen COL9A1 , and alpha 1 XIX collagen COL19A1 to human chromosome 6q12 q13 journal Genomics volume 41 issue 2 pages 236 ... by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes the alpha chain of type XII collagen, a member of the FACIT fibril associated collagens with interrupted triple helices collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding ... The mouse alpha 1 XII and human alpha 1 XII like collagen genes are localized on mouse chromosome 9 ... journal author Chiquet M, Mumenthaler U, Wittwer M, et al. title The chick and human collagen alpha1 ... of collagen XII expression by changes in tensile stress journal Exp. Cell Res. volume 247 ... pmc 139241 cite journal author Jin X, Iwasa S, Okada K, et al. title Shear stress induced collagen ... author Thierry L, Geiser AS, Hansen A, et al. title Collagen types XII and XIV are present in basement membrane zones during human embryonic development journal J. Mol. Histol. volume 35 issue 8 9 pages ...   more details




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