- Alkylating antineoplastic agent
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group C sub n sub H sub 2n 1 sub to DNA . ref name urlantineop cite web url http faculty.swosu.edu scott.long phcl antineop.htm title antineop work accessdate 2009 01 24 ref The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring. Since cancer cells, in general, proliferate faster and with less error correcting than healthy cells, cancer cells are more sensitive to DNA damage such as being alkylated. Alkylating agents are used to treat several cancers. However, they are also toxic to normal cells cytotoxic , leading to damage, in particular in Labile cell cells that divide frequently , as those in the gastrointestinal tract, bone marrow, testicles and ovaries, which can cause loss of fertility. Most of the alkylating agents are also carcinogenic . Hyperthermia is especially effective at enhancing the effects of alkylating agents. ref name pmid9081372 cite journal author Wiedemann GJ, Robins HI, Gutsche S, Mentzel M, Deeken M, Katschinski DM, Eleftheriadis S, Crah R, Weiss C, Storer B, Wagner T. title Ifosfamide, carboplatin and etoposide ICE combined with 41.8 degrees C whole body hyperthermia in patients with refractory sarcoma journal European Journal of Cancer volume 32A issue 5 pages 888 92 year 1996 month May pmid 9081372 url http cancerres.aacrjournals.org cgi reprint 54 20 5346.pdf ref History Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard , mustard gas and related chemical weapon s in World War I . The nitrogen mustards were the first alkylating agents used medically, as well as the first modern cancer chemotherapies. Goodman, Gilman, and others at Yale began ... Alkylating antineoplastic agents http www.cancernetwork.com cancer management 11 chapter03 article ... agents Category Alkylating antineoplastic agents Category Alkylating agents de Alkylantien fr Agent ... more details
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- Cell-cycle nonspecific antineoplastic agents
Cell cycle nonspecific antineoplastic agents CCNS refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle . ref name urlCancer Treatment Information Chemotherapy, Radiation Oncology, and Surgery OncoLink cite web url http cancer.med.upenn.edu treatment article.cfm?c 2&s 9&id 319 title Cancer Treatment Information Chemotherapy, Radiation Oncology, and Surgery & 124 OncoLink format work accessdate 2008 12 17 ref Alkylating antineoplastic agent are an example. References reflist Further reading cite journal author Alberts DS, Golde DW title DNA synthesis in multiple myeloma cells following cell cycle nonspecific chemotherapy journal Cancer Res. volume 34 issue 11 pages 2911 4 year 1974 month November pmid 4424360 doi url http cancerres.aacrjournals.org cgi pmidlookup?view long&pmid 4424360 cite journal author Ozawa S, Sugiyama Y, Mitsuhashi Y, Kobayashi T, Inaba M title Cell killing action of cell cycle phase non specific antitumor agents is dependent on concentration time product journal Cancer Chemother. Pharmacol. volume 21 issue 3 pages 185 90 year 1988 pmid 3129204 doi url Intracellular chemotherapeutic agents Category Antineoplastic drugs ... more details
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- Exisulind
unreferenced date September 2009 Exisulind is a drug used to treat cancer . It acts by inhibiting the enzyme cyclic guanosine monophosphate phosphodiesterase . Trademark by OSI Pharmaceuticals is Aptosyn. Category Antineoplastic drugs Antineoplastic drug stub ... more details
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- Chemoprotective agent
In the treatment of cancer , chemoprotective agents are drugs which protect healthy tissue from the toxic effects of anticancer drugs. External links http www.cancer.gov Templates db alpha.aspx?CdrID 45639 Chemoprotective entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Antineoplastic drugs antineoplastic drug stub oncology stub ... more details
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- Chemosensitizer
A chemosensitizer is a drug that makes tumor cells more sensitive to the effects of chemotherapy . External links http www.cancer.gov Templates db alpha.aspx?CdrID 45640 Chemosensitizer entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Antineoplastic drugs antineoplastic drug stub oncology stub ... more details
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- Dopastin
Dopastin is a drug that is considered an antihypertensive , as well as an antineoplastic . ref cite web title Drug Summary ICPC url url http www.icpc.biz ItemDetail.aspx?DATA 6MyPXPMOjizLx49xzsKsTKzS43Srmxex1BHYIzjfAnhGIdx1Nj3q5gy95tYr1zAr3TcvdIl6UBw 3D publisher ICPC accessdate 29 October 2011 ref References Reflist Cardiovascular drug stub Category Antihypertensive agents Category Antineoplastic drugs ... more details
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- Antiprogestin
An antiprogestin is a substance that prevents cells from making or using progesterone a hormone that plays a role in the menstrual cycle and pregnancy . Antiprogestins may stop some cancer cells from growing and they are being studied in the treatment of breast cancer . An antiprogestin is a type of hormone antagonist . External links http www.cancer.gov Templates db alpha.aspx?CdrID 561317 Antiprogestin entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Estrogens and progestogens Category Antineoplastic drugs antineoplastic drug stub genito urinary drug stub ... more details
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- Signal transduction inhibitor
Signal transduction inhibitors are drug s that may prevent the ability of cancer cells to multiply quickly and invade other tissues. External links http www.cancer.gov Templates db alpha.aspx?CdrID 44829 Signal transduction inhibitor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Antineoplastic drugs antineoplastic drug stub fr Inhibiteur de transduction de signal ... more details
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- COPP (chemotherapy)
Unreferenced stub auto yes date December 2009 Orphan date December 2009 COPP is a chemotherapy regimen for treatment of Non Hodgkin s lymphoma , consisting of treatment with cyclophosphamide , oncovin , procarbazine and prednisone . All drugs are administered intravenous ly. DEFAULTSORT Copp Category Chemotherapy regimens antineoplastic drug stub ... more details
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- C18H22O4
DISPLAYTITLE C sub 18 sub H sub 22 sub O sub 4 sub The molecular formula C sub 18 sub H sub 22 sub O sub 4 sub molar mass 302.36 g mol may refer to Enterodiol , a lignan Masoprocol , an antineoplastic drug Nordihydroguaiaretic acid MolFormDisambig ... more details
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- Taxoid
Taxoid s are a class of derivatives from taxol . ref Cite web url http www.usrf.org news 19MAY04taxotere Sci 20Am 20Taxoids 201996.pdf title Taxoids New Weapons against Cancer year 1996 ref They were developed for their anti cancer properties. See also the similar taxane s. Taxoids include Taxotere . References Reflist Category Mitotic inhibitors antineoplastic drug stub ... more details
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- Amphinex
Amphinex is a photosensitising agent used in photodynamic therapy for treating superficial cancers. It has had promising preliminary results in early trials on patients with advanced head and neck cancer ref http www.pcibiotech.no content successful completion third dose group amphinex study continued good tolerability and strong Successful completion of the third dose group in the Amphinex study. March 2010 ref ref http www.medicalnewstoday.com articles 176431.php PCI Biotech Reports Successful Completion Of Second Dose Group In Pivotal Amphinex R Trial. Jan 2010 ref ref Inoperable cancers killed by new laser surgery The Times. UK. 3 April 2010 p15 ref References reflist Category Antineoplastic drugs antineoplastic drug stub ... more details
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- Tamibarotene
chembox UNII Ref fdacite correct FDA UNII 08V52GZ3H9 ImageFile Tamibarotene.svg ImageSize IUPACName 4 1,1,4,4 tetramethyltetralin 6 yl carbamoyl benzoic acid OtherNames Section1 Chembox Identifiers CASNo 94497 51 5 ChEMBL 25202 PubChem 108143 ChemSpiderID 97231 Beilstein 3564473 DrugBank DB04942 SMILES O C O c1ccc cc1 C O Nc2ccc3c c2 C CCC3 C C C C InChI InChI 1S C22H25NO3 c1 21 2 11 12 22 3,4 18 13 16 9 10 17 18 21 23 19 24 14 5 7 15 8 6 14 20 25 26 h5 10,13H,11 12H2,1 4H3, H,23,24 H,25,26 Section2 Chembox Properties C 22 H 25 N 1 O 3 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Tamibarotene , also called retinobenzoic acid, is orally active, synthetic retinoid , developed to overcome Tretinoin all trans retinoic acid ATRA resistance, with potential antineoplastic activity. File Tamibarotene synth.png 500px Y. Hamada, I. Yamada, M. Uenaka, T. Sakata, US Patent 5,214,202 1993 . Further reading cite journal pmid 15563242 year 2004 title Tamibarotene AM 80, retinobenzoic acid, Tamibaro volume 5 issue 6 pages 359 62 journal Drugs in R&D Category Retinoids Category Antineoplastic drugs Category Benzoic acids Category Benzamides Category Tetralins Antineoplastic drug stub fa pt Tamibarotene ... more details
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- Hypogeusia
Hypogeusia is a reduced ability to taste things to taste sweet, sour, bitter, or salty substances . The complete lack of taste is referred to as ageusia . Causes of hypogeusia include the chemotherapy drug bleomycin , an antineoplastic antitumor antibiotic as well as zinc deficiency. citation needed date November 2007 Cognition, perception, emotional state and behaviour symptoms and signs Category Gustatory system med stub ... more details
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- Neurovax
Neurovax is a vaccine designed to treat patients with Multiple Sclerosis M.S. . Developed by Immune Response BioPharma, Inc. it is currently in phase II clinical trials. Neurovax is designed to stimulate FOXP3 regulatory T cells that can then suppress the autoreactive T cells in some patients. All work with Neurovax is now being developed by Immune Response BioPharma, Inc. and has licensed TCR FOXP3 Technology from OHSU in December 2011. External Links http www.immmuneresponsebiopharma.com Immune Response BioPharma Category Monoclonal antibodies Category Immunosuppressants Antineoplastic drug stub ... more details
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- Alkyl sulfonate
Alkyl sulfonates are ester s of alkane sulfonic acids with the general formula R SO sub 2 sub O R . They act as alkylation alkylating agents , some of them are used as alkylating antineoplastic agent s in the treatment of cancer , e.g. Busulfan . ref R mpp CD 2006, Georg Thieme Verlag 2006 ref References references Category Sulfonate esters organic chem stub nl Alkylsulfonaat ... more details
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- Chemoimmunotherapy
Chemoimmunotherapy is chemotherapy combined with immunotherapy . Chemotherapy uses different drugs to kill or slow the growth of cancer cells immunotherapy uses treatments to stimulate or restore the ability of the immune system to fight cancer. A common chemoimmunotherapy regimen is CHOP combined with rituximab CHOP R for B cell non Hodgkin lymphoma s. External links http www.cancer.gov Templates db alpha.aspx?CdrID 270867 NCI Dictionary of Cancer Terms Definition of chemoimmunotherapy Category Antineoplastic drugs oncology stub ... more details
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- Antimicrotubule agent
An antimicrotubule agent is a type of drug that blocks cell growth by stopping mitosis cell division . Antimicrotubule agents interfere with microtubules cellular structures that help move chromosomes during mitosis . They are used to treat cancer . External links http www.cancer.gov Templates db alpha.aspx?CdrID 306526 Antimicrotubule agent entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict oncology stub antineoplastic drug stub Category Mitotic inhibitors ... more details
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- Angiozyme
Angiozyme is a substance that is being studied in the treatment of kidney cancer . It may prevent the growth of blood vessels from surrounding tissue to the tumor . It belongs to the families of drugs called VEGF receptor and angiogenesis inhibitors . Also called RPI.4610 . External links http www.cancer.gov Templates db alpha.aspx?CdrID 413942 Angiozyme entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict oncology stub Category Antineoplastic drugs ... more details
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- Dose-dense chemotherapy
Dose dense chemotherapy is a chemotherapy treatment plan in which drugs are given with less time between treatments than in a standard chemotherapy treatment plan. Also see IFL chemotherapy External links http www.cancer.gov Templates db alpha.aspx?CdrID 322855 Dose dense chemotherapy entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict oncology stub Category Antineoplastic drugs ... more details
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- Antileukemic drug
Unreferenced date October 2008 Antileukemic drugs , Chemotherapy anticancer drugs that are used to treat one or more types of leukemia , include Mercaptopurine 6 Mercaptopurine 6 Thioguanine Aminopterin Arsenic trioxide Asparaginase Cladribine Clofarabine Cyclophosphamide Cytosine arabinoside Dasatinib Daunorubicin Decitabine Dexamethasone Etoposide Fludarabine Gemtuzumab ozogamicin Idarubicin Imatinib mesylate Interferon Interleukin 2 Melphalan Methotrexate Mitoxantrone Nelarabine Nilotinib Oblimersen Pegaspargase Pentostatin Prednisone Rituximab Tretinoin Vincristine Category Leukemia antineoplastic drug stub ... more details
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- Rhabdomycin
Rhabdomycin is a drug that is sometimes used to treat such ailments as rhabdomyosarcoma , ref http www.fda.gov OHRMS DOCKETS AC 01 transcripts 3756t1 01.pdf ref a type of cancer, specifically a sarcoma cancer of connective tissues , in which the cancer cells are thought to arise from skeletal muscle progenitors. It can also be found attached to muscle tissue, wrapped around intestines, or anywhere, to exclude the neck area. References references Category Drugs Category Sarcoma antineoplastic drug stub ... more details
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- Biologically effective dose
unreferenced date November 2011 The Biologically effective dose is the dose of radiation or a drug that must be delivered to a target organ or tissue, to have a desired therapeutic effect Radiation oncology Category Radioactivity Category Radiation health effects Category Radiation oncology Category Medical physics Category Radiobiology Category Pharmacology Category Antineoplastic drugs Category Oncology Category Cancer treatments medicine stub ... more details
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- ATC code L
ATC codes lead L Antineoplastic and immunomodulating agents References Reflist Major drug groups Intracellular chemotherapeutic agents Extracellular chemotherapeutic agents Sex hormones Immunostimulants Immunosuppressants Category ATC codes L Category Antineoplastic and immunomodulating drugs Category Article Feedback 5 ca Codi ATC L cs ATC k d L es Anexo C digo ATC L fr ATC code L gl C digo ATC L ko ATC L id Kode ATC L hu ATC L Daganatellenes szerek s immunmodul torok pl ATC L pt C digo ATC L ro Cod ATC L sl Zdravila z delovanjem na novotvorbe in imunomodulatorji sr ATC kod L fi ATC koodi L sv ATC kod L Tum rer och rubbningar i immunsystemet th ATC L zh ATC L ... more details
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- Uramustine
Unreferenced stub auto yes date December 2009 Drugbox Verifiedfields changed verifiedrevid 409092073 IUPAC name 5 bis 2 chloroethyl amino 1H pyrimidine 2,4 dione image uramustine.svg width 200px Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound 5 metabolism elimination half life excretion Kidney Renal Identifiers CASNo Ref cascite CAS number Ref cascite correct ?? CAS number 66 75 1 ATC prefix none ATC suffix ATC supplemental PubChem 6194 DrugBank Ref drugbankcite changed drugbank DrugBank DB00791 UNII Ref fdacite changed FDA UNII W7KQ46GJ8U KEGG Ref keggcite correct kegg KEGG D06265 ChEMBL Ref ebicite changed EBI ChEMBL 1488 Chemical data C 8 H 11 Cl 2 N 3 O 2 molecular weight 252.097 Gram g Mole unit mol Uramustine International Nonproprietary Name INN or uracil mustard is a chemotherapy medication drug which belongs to the class of alkylating antineoplastic agent alkylating agent s. It is used in lymph atic malignancies such as non Hodgkin s lymphoma . It works by damaging DNA , primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division . The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil . Chemotherapeutic agents Category Alkylating antineoplastic agents Category IARC Group 2B carcinogens Category Nitrogen mustards Category Pyrimidinediones Category Organochlorides antineoplastic drug stub ... more details
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