Infobox protein family Symbol Apolipoprotein Name Apolipoprotein image PDB 1nfn EBI.jpg width caption apolipoprotein e3 apoe3 Pfam PF01442 Pfam clan InterPro IPR000074 SMART PROSITE MEROPS SCOP 1oef TCDB OPM family 193 OPM protein 3r2p CAZy CDD Apolipoproteins are protein s that bind lipids oil soluble substances such as fat and cholesterol to form lipoproteins and transport the lipids through the lymphatic system lymphatic and circulatory system circulatory systems. The lipid components of lipoproteins are not soluble in water however, because of their detergent like amphipathic properties, apolipoproteins and other amphipathic molecules such as phospholipids can surround the lipids, creating ... apolipoprotein gene family are related. ref name pmid15234552 cite journal author Saito H, Lund ... dimensional structure of the LDL receptor binding domain of human apolipoprotein E journal Science ... for LDL receptors, apoA I for HDL receptors Classes There are two major types of apolipoproteins. Apolipoprotein ... and several sub classes A apo Apolipoprotein A1 A I , apo APOA2 A II , APOA4 apo A IV , and apo APOA5 A V B Apolipoprotein B apo B48 and apo B100 Apolipoprotein C C apo Apolipoprotein C1 C I , apo APOC2 C II , apo Apolipoprotein C3 C III , and apo Apolipoprotein C4 C IV Apolipoprotein D D Apolipoprotein E E Apolipoprotein H H Exchangeable apolipoproteins apoA, apoC and apoE have the same genome ... been described, and many of them alter their structure and function. Synthesis and regulation Apolipoprotein synthesis in the intestine is regulated principally by the fat content of the diet. Apolipoprotein ... apoproteins. References reflist See also Apolipoprotein L Apoprotein External links http www.ncbi.nlm.nih.gov ... apolipoprotein.html Apolipoprotein AI Mutations and Information protein stub Lipoproteins InterPro content IPR000074 Category Apolipoproteins ca Apolipoprote na da Apolipoprotein de Apolipoprotein es ... ru tr Apolipoprotein zh ... more details
protein Name apolipoprotein A II caption image width HGNCid 601 Symbol APOA2 AltSymbols EntrezGene 336 OMIM 107670 RefSeq NM 001643 UniProt P02652 PDB ECnumber Chromosome 1 Arm q Band 21 LocusSupplementaryData q23 Apolipoprotein A2 is an apolipoprotein found in high density lipoprotein HDL cholesterol in Blood plasma plasma . It has an approximate molecular weight 17 Dalton unit KDa ref http emedicine.medscape.com article 121187 overview ref . References Reflist 2 External links MeshName Apolipoprotein A II gene 1 stub Lipoproteins Category Apolipoproteins ru A2 sr Apolipoprotein A2 ... more details
In the field of molecular biology , apolipoprotein C is a family of four low molecular weight apolipoprotein s, designated as Apolipoprotein C1 C I , APOC2 C II , Apolipoprotein C3 C III , and Apolipoprotein C4 C IV that are surface components of chylomicron s, very low density lipoprotein VLDL , and high density lipoprotein HDL . In the fasting state, the C apolipoproteins are mainly associated with HDL. During absorption of dietary fat, the C apoli poproteins preferentially redistribute to the surface of the triglyceride rich chylomicrons and VLDL. ref name pmid6099394 cite journal author Mahley RW, Innerarity TL, Rall SC, Weisgraber KH title Plasma lipoproteins apolipoprotein structure and function journal J. Lipid Res. volume 25 issue 12 pages 1277 94 year 1984 month December pmid 6099394 doi url issn ref References Reflist Category Proteins protein stub ... more details
PBB geneid 347 Apolipoprotein D is a protein that in humans is encoded by the APOD gene . ref name pmid2439269 ... apolipoprotein D gene gene sequence, chromosome localization, and homology to the alpha 2u globulin ... apolipoprotein D cDNA journal J Biol Chem volume 261 issue 35 pages 16535 9 year 1987 month Jan pmid 3453108 pmc doi ref ref name entrez cite web title Entrez Gene APOD apolipoprotein D url http ... Apolipoprotein D Apo D is a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol binding protein ..., Werner R, W nsch L, Cario G, Demeter J, Hiort O, Riepe F, Brooks JD, Holterhus PM title Apolipoprotein ... cite journal author Rassart E, Bedirian A, Do Carmo S, et al. title Apolipoprotein D journal Biochim ... 00162 X cite journal author Peitsch MC, Boguski MS title Is apolipoprotein D a mammalian bilin binding ... author Balb n M, Freije JM, Fueyo A, et al. title Apolipoprotein D is the major protein component ... R title Multiple RFLPs at the human apolipoprotein D APOD locus journal Nucleic Acids Res. volume 15 ... acyltransferase and apolipoprotein D using HPLC electrospray mass spectrometry and sequential ... Structure of human apolipoprotein D locations of the intermolecular and intramolecular disulfide ... gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members ... al. title A human axillary odorant is carried by apolipoprotein D journal Proc. Natl. Acad. Sci. U.S.A. ... Apolipoprotein D interacts with the long form leptin receptor a hypothalamic function in the control ... apolipoprotein D during mouse embryogenesis journal Mech. Dev. volume 110 issue 1 2 pages 225 9 year ... DR, Parikh VV title Elevated plasma level of apolipoprotein D in schizophrenia and its treatment and outcome ... variation in apolipoprotein D affects the risk of Alzheimer disease in African Americans journal ..., Sutcliffe JG, et al. title Apolipoprotein D levels are elevated in prefrontal cortex of subjects ... more details
nmr structure of human apolipoprotein c ii in the presence of sds Pfam PF05355 Pfam clan InterPro IPR008019 SMART PROSITE MEROPS SCOP 1by6 TCDB OPM family OPM protein CAZy CDD Apolipoprotein C2 or Apolipoprotein ... Apolipoprotein C II is a novel substrate for matrix metalloproteinases journal Biochem. Biophys ... entrez cite web title Entrez Gene APOC2 apolipoprotein C II url http www.ncbi.nlm.nih.gov sites ... WP430 highlight APOC2 See also Apolipoprotein C References reflist refbegin 2 PBB Further reading ... low density apolipoprotein C II of human plasma. journal Proc. Natl. Acad. Sci. U.S.A. volume ... and secondary structure of a carboxy terminal functional fragment of apolipoprotein CII. journal Eur ... cite journal author Hegele RA, Connelly PW, Maguire GF, et al. title An apolipoprotein CII ... of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency Apo CII ... DL, et al. title The structure of the human apolipoprotein C II gene. Electron microscopic analysis ... apolipoprotein genes. journal J. Biol. Chem. volume 260 issue 28 pages 15211 21 year 1986 pmid 2415514 doi cite journal author Fojo SS, Lohse P, Parrott C, et al. title A nonsense mutation in the apolipoprotein C IIPadova gene in a patient with apolipoprotein C II deficiency. journal J. Clin. Invest ... author Jackson CL, Bruns GA, Breslow JL title Isolation of cDNA and genomic clones for apolipoprotein ... of a patient with a deficiency of apolipoprotein C II. journal J. Biol. Chem. volume 263 issue .... title Donor splice site mutation in the apolipoprotein Apo C II gene Apo C IIHamburg of a patient with Apo ... JA title Structure of apolipoprotein C IIToronto, a nonfunctional human apolipoprotein. journal Proc ... apolipoprotein C II total solid phase synthesis and chemical and biological characterization. journal .... title The human apolipoprotein C II gene sequence contains a novel chromosome 19 specific minisatellite ... 3558370 doi cite journal author Connelly PW, Maguire GF, Little JA title Apolipoprotein CIISt. Michael ... more details
PBB geneid 79135 Infobox protein family Symbol ApoO Name ApoO image width caption Pfam PF09769 Pfam clan InterPro IPR019166 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene . APOO is a member of the apolipoprotein family. ref name pmid16956892 cite journal author Lamant M, Smih F, Harmancey R, Philip Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P title ApoO, a novel apolipoprotein, is an original glycoprotein up regulated by diabetes in human heart journal J. Biol. Chem. volume 281 issue 47 pages 36289 302 year 2006 month November pmid 16956892 doi 10.1074 jbc.M510861200 ref The human, apolipoprotein O is a 198 amino acid s protein that contains a 23 amino acids long signal peptide . The apoprotein is secreted by a microsome microsomal triglyceride transfer protein MTTP dependent mechanism, probably as a VLDL associated protein that is subsequently transferred to high density lipoprotein HDL . Apolipoprotein O is the first chondroitin sulphate chondroitine sulphate polymer chain containing apolipoprotein. ref name pmid16956892 cite journal author Lamant M, Smih F, Harmancey R, Philip Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P title ApoO, a novel apolipoprotein, is an original glycoprotein up regulated by diabetes in human heart journal J. Biol. Chem. volume 281 issue 47 pages 36289 302 year 2006 month November pmid 16956892 doi 10.1074 jbc.M510861200 url ref Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including high density lipoprotein HDL , low density lipoprotein LDL and very low density lipoprotein VLDL . References reflist Further reading refbegin 2 cite journal author Talmud PJ, Drenos F, Shah S, et al. title Gene centric association s ... more details
Pfam box Symbol ApoL Name Apolipoprotein L image width caption Pfam PF05461 InterPro IPR008405 SMART Prosite SCOP TCDB OPM family OPM protein PDB Apolipoprotein L Apo L belongs to the High density lipoprotein high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment . There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia. ref name PUB00011252 cite journal author Arai H, Mimmack ML, Ryan M, Baba H, Navarro ruiz J, Iritani S, Faull RL, Mckenna PJ, Jones PB, Starkey M, Emson PC, Bahn S title Gene expression analysis in schizophrenia reproducible up regulation of several members of the apolipoprotein L family located in a high susceptibility locus for schizophrenia on chromosome 22 journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 7 pages 4680 4685 year 2002 pmid 11930015 doi 10.1073 pnas.032069099 pmc 123707 ref Human proteins containing this domain APOL1 APOL2 APOL3 APOL4 APOL5 APOL6 APOLD1 References reflist InterPro content IPR008405 Category Apolipoproteins Category Protein domains Category Protein families ... more details
Metabolism of VLDL and LDL containing apolipoprotein C III and not other small apolipoproteins R2 journal ... fatty liver disease. Interactive pathway map StatinPathway WP430 highlight Apolipoprotein C3 See also Apolipoprotein C External links MeshName Apolipoprotein C III References reflist Further reading ... Apolipoprotein C III Lys58 Glu . Identification of an apolipoprotein C III variant in a family ... of the human apolipoprotein A4 gene APOA4 journal Proc. Natl. Acad. Sci. U.S.A. volume 83 issue ... cite journal author Karathanasis SK title Apolipoprotein multigene family tandem organization of human apolipoprotein AI, CIII, and AIV genes journal Proc. Natl. Acad. Sci. U.S.A. volume 82 issue ... Zannis VI, Cole FS, Jackson CL title Distribution of apolipoprotein A I, C II, C III, and E mRNA in fetal human tissues. Time dependent induction of apolipoprotein E mRNA by cultures of human monocyte ... apolipoprotein genes. Apo AII presents a unique functional intron exon junction journal ... plasma apolipoprotein C III from normolipidemic subjects journal FEBS Lett. volume 197 issue 1 2 ... R, Herbert P title The complete amino acid sequence of alanine apolipoprotein apoC 3 , and apolipoprotein ... Wilson B, Miller J title Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic ... LA, Halaas JL title An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified ... author Wu JH, Kao JT, Wen MS, Lo SK title DNA polymorphisms at the apolipoprotein A1 CIII loci ... activation of the human apolipoprotein C III promoter by upstream stimulatory factor and hepatic ... doi 10.1074 jbc.M200227200 cite journal author Chhabra S, Narang R, Krishnan LR title Apolipoprotein ... more details
PBB geneid 335 Apolipoprotein A I is a protein that in humans is encoded by the APOA1 gene . ref name ..., Karathanasis SK, Zannis VI title Isolation and characterization of cDNA clones for human apolipoprotein ... author Arinami T, Hirano T, Kobayashi K, Yamanouchi Y, Hamaguchi H title Assignment of the apolipoprotein ... issn ref It has a specific role in lipid metabolism . Apolipoprotein A I is the major protein component ... C title Serum prostacyclin stabilizing factor is identical to apolipoprotein A I Apo A I . A novel ... Entrez Gene APOA1 apolipoprotein A I url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... R, Hegele RA, Pajukanta P, Engert JC, Genest J, Marcil M title A novel nonsense apolipoprotein ..., it was the first known molecular abnormality of apolipoprotein s. ref name pmid6785551 cite journal ... apolipoprotein A I a study of secondary structural and functional properties journal J. Lipid Res ... . ref cite journal author Chiesa G, Sirtori CR title Apolipoprotein A I Milano current perspectives ... Apolipoprotein AI CIII AIV gene cluster Lately, two novel susceptibility haplotypes i.e. P2 S2 X1 ... author Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS title Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment ... joint meniscus is formed from apolipoprotein A I journal Arthritis Rheum. volume 54 issue 11 pages ... Ma J, Liao XL, Lou B, Wu MP title Role of apolipoprotein A I in protecting against endotoxin toxicity ... M, Oxley D, Leweke FM, Bahn S title Independent protein profiling studies show a decrease in apolipoprotein ... I Apolipoprotein A I and APOE interact epistatically to modulate triglyceride levels in Coronary ..., Beers A, Haas MJ, Wong NC, Steinmeyer A, Zugel U, Mooradian AD title Inhibition of apolipoprotein AI ... 2003 pmid 12801612 doi 10.1016 S0021 9150 03 00094 7 ref Potential Binding Partners Apolipoprotein ... for this interaction is unknown. Interactions Apolipoprotein A1 has been shown to Protein protein ... more details
of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19 journal Hum ... EC title Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic ... by this gene is a member of the apolipoprotein C family. This gene is expressed primarily in the liver ... 19, where it resides within an apolipoprotein gene cluster. Alternatively spliced transcript ... determined. ref name entrez cite web title Entrez Gene APOC1 apolipoprotein C I url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 341 accessdate ref Apolipoprotein ... like other apolipoprotein C , it is found primarily within High density lipoprotein HDL , while after ... of C I apoLp Ser , an apolipoprotein from human very low density lipoproteins. journal J. Biol. Chem ... NA, et al. title Two copies of the human apolipoprotein C I gene are linked closely to the apolipoprotein ... al. title There are two gene sequences for human apolipoprotein CI apo CI on chromosome 19, one of which ... S title The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein ... of mRNAs encoding the precursor for human apolipoprotein CI. journal Nucleic Acids Res. volume ... corresponding to human apolipoprotein C I residues 7 24 and 35 53 in the presence of sodium dodecyl ... apolipoprotein C I by CD and 1H NMR spectroscopy. journal Protein Sci. volume 6 issue 9 pages ... al. title Human apolipoprotein C I accounts for the ability of plasma high density lipoproteins to inhibit ... more details
PBB geneid 338 Apolipoprotein B APOB or ApoB are the primary apolipoprotein s of chylomicron s and low ... exactly what functional role APOB plays in LDL, it is the primary apolipoprotein component ... Image Free text.png Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural ... are not viable. ref Image Free text.png Knockout of the Mouse Apolipoprotein B Gene Results in Embryonic ... for invasive Staphylococcus aureus infection. The mechanism of antagonism entails binding Apolipoprotein ... in apolipoprotein B are more susceptible to invasive bacterial infection. ref cite journal author ..., Gresham HD. title Apolipoprotein B is an innate barrier against invasive Staphylococcus aureus infection ... using apolipoprotein B the Copenhagen City Heart Study. journal Arterioscler Thromb Vasc Biol year ... a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes ... 8 1 1 Free Full Text ref Interactions Apolipoprotein B has been shown to Protein protein interaction ... Haya year 2003 month Feb. title Nascent lipidated apolipoprotein B is transported to the Golgi ... Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum resident chaperones ERp72, GRP94, calreticulin, and BiP interacts with apolipoprotein ... StatinPathway WP430 highlight Apolipoprotein B Regulation The Gene expression expression of APOB is regulated by cis regulatory element s in the Apolipoprotein B apoB 5 UTR cis regulatory element APOB ... title Translational control of apolipoprotein B mRNA regulation via cis elements in the 5 and 3 ... A novel form of tissue specific RNA processing produces apolipoprotein B48 in intestine journal Cell ... N, Jarmuz A, von Haeseler A, Scott J title C U editing of apolipoprotein B mRNA in marsupials .... ref name pmid1939106 cite journal author Lau PP, Xiong WJ, Zhu HJ, Chen SH, Chan L title Apolipoprotein ... more details
PBB geneid 346 Apolipoprotein C IV , also known as apolipoprotein C4 , is a protein that in humans is encoded by the APOC4 gene . ref name entrez cite web title Entrez Gene apolipoprotein C IV url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 346 accessdate ref ref name pmid8530039 cite journal author Allan CM, Walker D, Segrest JP, Taylor JM title Identification and characterization of a new human gene APOC4 in the apolipoprotein E, C I, and C II gene locus journal Genomics volume 28 issue 2 pages 291 300 year 1995 month July pmid 8530039 doi 10.1006 geno.1995.1144 url issn ref Function Apolipoprotein apo C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. Apo C4 is a 3.3 kb gene consisting of 3 exons and 2 introns it is located 0.5 kb 5 to the APOC2 gene. ref name entrez References reflist Further reading refbegin 2 cite journal author Kim E, Li K, Lieu C, et al. title Expression of apolipoprotein C IV is regulated by Ku antigen peroxisome proliferator activated receptor gamma complex and correlates with liver steatosis. journal J. Hepatol. volume 49 issue 5 pages 787 98 year 2008 pmid 18809223 doi 10.1016 j.jhep.2008.06.029 pmc 2644636 cite journal author Burkhardt R, Kenny EE, Lowe JK, et al. title Common SNPs in HMGCR in micronesians and whites associated with LDL cholesterol levels affect alternative splicing of exon13 journal Arterioscler. Thromb. Vasc. Biol. volume 28 issue 11 pages 2078 84 year 2008 pmid 18802019 doi 10.1161 ATVBAHA.108.172288 pmc 2764366 cite journal author Willer CJ, Sanna S, Jackson AU, et al ... author Mak PA, Laffitte BA, Desrumaux C, et al. title Regulated expression of the apolipoprotein ... variation in human apolipoprotein C4 gene and its effect on plasma lipid profile journal Atherosclerosis ... in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants ... more details
PBB geneid 348 Apolipoprotein E APOE is a class of apolipoprotein found in the chylomicron and intermediate ... APOE apolipoprotein E url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... . ref name pmid20182542 cite journal author Zhang HL, Wu J, Zhu J title The Role of Apolipoprotein ... to chromosome 19 human chromosome 19 in a cluster with Apolipoprotein C1 and the Apolipoprotein C2 ... of aggregates of the peptide beta amyloid . Apolipoprotein E enhances proteolytic break down of this peptide ..., Gaskell PC, Small GW, Roses AD, Haines JL, Pericak Vance MA title Gene dose of apolipoprotein E type ... PC, Rimmler JB, Locke PA, Conneally PM, Schmader KE title Protective effect of apolipoprotein ... map StatinPathway WP430 highlight Apolipoprotein E References Reflist 2 Further reading Refbegin 2 cite ... and cross linking of amyloid fibrils by human apolipoprotein E journal J. Biol. Chem. volume 282 issue ... cite journal author Mahley RW title Apolipoprotein E cholesterol transport protein with expanding ... science.3283935 cite journal author Strittmatter WJ, Roses AD title Apolipoprotein E and Alzheimer ..., Frants RR, Havekes LM title Genetic heterogeneity of apolipoprotein E and its influence on plasma ..., biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism ... cell surface heparan sulfate proteoglycans and apolipoprotein E journal J. Lipid Res. volume 40 issue 1 pages 1 16 year 1999 pmid 9869645 doi cite journal author Mahley RW, Rall SC title Apolipoprotein ... Parasuraman R, Greenwood PM, Sunderland T title The Apolipoprotein E Gene, Attention, and Brain ... 0894 4105.16.2.254 pmc 1350934 cite journal author Bocksch L, Stephens T, Lucas A, Singh B title Apolipoprotein ... RW title Apolipoprotein E diversity of cellular origins, structural and biophysical properties, and effects ... KK title Apolipoprotein E polymorphism, age and coronary heart disease journal Ageing ... doi 10.1016 j.psyneuen.2007.05.015 cite journal author Raber J title Role of Apolipoprotein E ... more details
PBB geneid 350 Apolipoprotein H Apo H , previously known as sub 2 sub glycoprotein I, beta 2 glycoprotein I , is a multifunctional apolipoprotein . One of its functions is to bind cardiolipin . When bound the structure of cardiolipin and Apo H both undergo large changes in structure. ref name pmid7586693 cite journal author Borchman D, Harris EN, Pierangeli SS, Lamba OP title Interactions and molecular structure of cardiolipin and beta 2 glycoprotein 1 beta 2 GP1 journal Clin. Exp. Immunol. volume 102 issue 2 pages 373 8 year 1995 pmid 7586693 doi 10.1111 j.1365 2249.1995.tb03792.x pmc 1553418 ref Within the structure of Apo H is a stretch of positively charged amino acids, protein sequence positions 282 287 Lys Asn Lys Glu Lys Lys, are involved in phospholipid binding See image on right . ref name pmid8871678 cite journal author Sheng Y, Sali A, Herzog H, Lahnstein J, Krilis SA title Site directed mutagenesis of recombinant human beta 2 glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti cardiolipin antibody activity journal J. Immunol. volume 157 issue 8 pages 3744 51 year 1996 pmid 8871678 doi ref Apo H has a complex involvement in agglutination, it appears to alter ADP mediated agglutenation of platlets. ref name pmid4082080 cite journal author Nimpf J, Wurm H, Kostner GM title Interaction of beta 2 glycoprotein I with human blood platelets influence upon the ADP induced aggregation journal Thromb. Haemost. volume 54 ... in autoimmune antiphospholipid syndrome requires apolipoprotein H. ref name pmid2349221 cite ... glycoprotein I apolipoprotein H journal Proc. Natl. Acad. Sci. U.S.A. volume 87 issue 11 pages 4120 ... from antibodies that bind thrombin, serum phospholipids and are called anti apolipoprotein antibodies . In autoimmune disease, anti apolipoprotein antibodies Anti sub 2 sub glycoprotein I antibodies ... sclerosis . References Reflist 2 External links MeshName Apolipoprotein H Autoantigens Lipoproteins ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB 34399 ICD10 ICD9 ICDO OMIM 107730 MedlinePlus eMedicineSubj eMedicineTopic MeshID D052476 Apolipoprotein B deficiency also known as Familial defective apolipoprotein B 100 is an autosomal dominant disorder resulting from a missense mutation which reduces the affinity of apoB 100 for the low density lipoprotein receptor LDL Receptor ref Kumar V, Butcher SJ, rni K, Engelhardt P, Heikkonen J, et al. 2011 Three Dimensional cryoEM Reconstruction of Native LDL Particles to 16 Resolution at Physiological Body Temperature. http www.plosone.org article info 3Adoi 2F10.1371 2Fjournal.pone.0018841 ref YouTube id CtFwss81GBk title see native LDL ApoB structure at 37 C . This causes impairments in LDL catabolism, resulting in increased levels of low density lipoprotein in the blood. The clinical manifestations are similar to diseases produced by mutations of the LDL receptor, such as familial hypercholesterolemia . Treatment may include, niacin or statin or ezetimibe . ref name Harrison s cite book author Braunwald, Eugene Hauser, Stephen L. et al. title Harrison s Principles of Internal Medicine publisher McGraw hill location year 2001 pages 2246 2247 isbn 0 07 007272 8 oclc doi accessdate ref rp 534 It is also known as normotriglyceridemic hypobetalipoproteinemia . ref name pmid15984016 cite journal author Homer VM, George PM, du Toit S, Davidson JS, Wilson CJ title Mental retardation and ataxia due to normotriglyceridemic hypobetalipoproteinemia journal Ann. Neurol. volume 58 issue 1 pages 160 3 year 2005 month July pmid 15984016 doi 10.1002 ana.20531 ref See also Familial hypercholesterolemia References reflist Lipid metabolism disorders Category Skin conditions resulting from errors in metabolism Category Lipid metabolism disorders Cutaneous condition stub ... more details
AutoAbBox Autoantigen Apolipoprotein, br sub 2 sub Glycoprotein 1 OneIsoform Yes OneIsoformSpecialName Apolipoprotein H OneGene APOH OneOrgan Cardiovascular OneTissue serum OneCell blood platelets OneAlso serum proteins OneDisease Idiopathic Thrombosis , br Sclerosis medicine Sclerosis , br lupus erythematosus Systemic lupus erythematosus OneIgClass OneIgGSubclass OneHLA1 HLA DR4 DR4 HLA DQ3 DQ3 OneHLA2 HLA DR53 DR53 OneHLA3 DRB1 0402 DR4 OneAssociatedGene OneTCellRestr OneTrigger In autoimmune disease, anti apolipoprotein H AAHA antibodies, also called anti sub 2 sub glycoprotein I antibodies, comprise a subset of anti cardiolipin antibodies and lupus anticoagulant . These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. ref name pmid1782567 cite journal author Viard JP, Amoura Z, Bach JF title Anti beta 2 glycoprotein I antibodies in systemic lupus erythematosus a marker of thrombosis associated with a circulating anticoagulant language French journal C. R. Acad. Sci. III, Sci. Vie volume 313 issue 13 pages 607 12 year 1991 pmid 1782567 doi ref . As a result AAHA are strongly implicated in autoimmune deep vein thrombosis . Also, it was proposed that AAHA is responsible for lupus anticoagulant . However, antiphospholipid syndrome antiphospholipid antibodies bind phospholipids at sites similar to sites bound by anti coagulants such as PAP1 sites and augment anti coagulation activity ref name pmid1372614 cite journal author Sammaritano LR, Gharavi AE, Soberano C, Levy RA, Lockshin MD title Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein journal J. Clin. Immunol. volume 12 issue 1 pages 27 35 year 1992 pmid 1372614 doi 10.1007 BF00918270 ref . This contrasts with the major, specific ... activities. Image Apolipoprotein H.png thumb 150px left structure of Apolipoprotein H AAHA interferes ... reflist Autoantibodies DEFAULTSORT Anti Apolipoprotein Antibodies Category Autoantibodies T ... more details
Infobox rfam Name Apolipoprotein B apoB 5 UTR cis regulatory element image RF00463.jpg width caption Predicted secondary structure and sequence conservation of ApoB 5 CRE Symbol ApoB 5 CRE AltSymbols Rfam RF00463 miRBase miRBase family RNA type Cis regulatory element Cis reg Tax domain Eukaryota GO SO SO 0000204 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The apolipoprotein B apoB 5 UTR cis regulatory element is an cis regulatory element RNA element located in the 5 UTR of the human apoB mRNA . This structured element increases translation of the apoB protein or a reporter gene. ref cite journal last Pontrelli first L coauthors Sidiropoulos KG, Adeli K year 2004 title Translational control of apolipoprotein B mRNA regulation via cis elements in the 5 and 3 untranslated regions journal Biochemistry volume 43 pages 6734&ndash 6744 pmid 15157107 doi 10.1021 bi049887s issue 21 ref References reflist 1 External links Rfam id RF00463 name Apolipoprotein B apoB 5 UTR cis regulatory element Category Cis regulatory RNA elements molecular cell biology stub ... more details
Apoprotein can refer to Apoenzyme Cofactors Apoenzyme , the protein part of an enzyme without its characteristic prosthetic group . Apolipoprotein , a lipid binding protein that is a constituent of the plasma lipoprotein . disambig ja ... more details
APOE may refer to Apolipoprotein E , a main apoprotein of the chylomicron, also studied for its involvement in Alzheimer s Disease risk. Professional Oklahoma Educators , an organization in Oklahoma formerly known as the Association of Professional Oklahoma Educators or APOE. disambig ... more details
because of the apolipoprotein B apolipoprotein B 100 apoB 100 and apoE they contain and are endocytosis ... the content of triglyceride, they become LDL, with apoB 100 as the primary apolipoprotein. The LDL ... more details
PBB geneid 116519 Apolipoprotein A V is a protein that in humans is encoded by the APOA5 gene . ref name pmid11588264 cite journal author Len A. Pennacchio Pennacchio LA , Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM title An apolipoprotein influencing triglycerides in humans ... title Apolipoprotein A V a novel apolipoprotein associated with an early phase of liver regeneration ... jbc.M106888200 ref ref name entrez 116519 cite web title Entrez Gene APOA5 apolipoprotein A V ... ref The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride ... Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS, Olivecrona G title Endocytosis of Apolipoprotein ... proximal to the apolipoprotein gene cluster on chromosome 11q23. ref name entrez 116519 Interactive pathway map StatinPathway WP430 highlight APOA5 See also Apolipoprotein References reflist Further ... LA , Rubin EM title Apolipoprotein A5, a newly identified gene that affects plasma triglyceride ..., Helleboid Chapman A, et al. title Is apolipoprotein A5 a novel regulator of triglyceride rich lipoproteins ... K, Ryan RO title Characterization of apolipoprotein A V structure and mode of plasma triacylglycerol ... apolipoprotein A5 haplotypes influence human plasma triglyceride levels journal Hum. Mol. Genet ... P, Jakel H, et al. title Apolipoprotein A5, a crucial determinant of plasma triglyceride levels ... journal author Prieur X, Coste H, Rodriguez JC title The human apolipoprotein AV gene is regulated ... and interfacial properties of human apolipoprotein A V journal J. Biol. Chem. volume 278 issue ... A, Vr bl k M, Ceska R, et al. title T 1131 C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic .... title Structure function studies of human apolipoprotein A V a regulator of plasma lipid homeostasis ... cite journal author Kao JT, Wen HC, Chien KL, et al. title A novel genetic variant in the apolipoprotein ... A, Ceska R, et al. title Ser19 Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic ... more details
composed of triglycerides 85 and contain some cholesterol and cholesteryl ester s. The main apolipoprotein component is Apolipoprotein B apolipoprotein B 48 APOB48 . Mature chylomicron While circulating ... donates Apolipoprotein C2 apolipoprotein C II APOC2 and apolipoprotein E APOE to the nascent chylomicron ... more details
Infobox protein family Symbol ApoLp III Name ApoLp III image PDB 1eq1 EBI.jpg width caption nmr structure of an exchangeable apolipoprotein manduca sexta apolipophorin iii Pfam PF07464 Pfam clan InterPro IPR010009 SMART PROSITE MEROPS SCOP 1eq1 TCDB OPM family OPM protein CAZy CDD In molecular biology, the apolipophorin III family of proteins are a family of exchangeable apolipoproteins . Exchangeable apolipoproteins constitute a functionally important protein family family of proteins that play critical roles in lipid transport and lipoprotein metabolism Regulation and control metabolism . Apolipophorin III apoLp III is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diglyceride diacylglycerol DAG from the fat body lipid storage depot to flight muscle s in the adult life stage. ref name pmid11818551 cite journal author Wang J, Sykes BD, Ryan RO title Structural basis for the conformational adaptability of apolipophorin III, a helix bundle exchangeable apolipoprotein journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 3 pages 1188 93 year 2002 month February pmid 11818551 pmc 122165 doi 10.1073 pnas.032565999 url ref References reflist InterPro content IPR010009 Category Protein families ... more details
pmid11418126 cite journal author Duan J, Dahlback B, Villoutreix BO title Proposed lipocalin fold for apolipoprotein ... ref name entrez cite web title Entrez Gene APOM apolipoprotein M url http www.ncbi.nlm.nih.gov sites ... title summary text The protein encoded by this gene is an apolipoprotein and member of the lipocalin ... of apolipoprotein M in HepG2 cells journal Biochem. Biophys. Res. Commun. volume 292 issue 4 ... X, Zheng L, et al. title Specific tissue expression and cellular localization of human apolipoprotein ... DQ, Pearson ER, et al. title Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor 1alpha haploinsufficiency is associated with reduced serum apolipoprotein M levels ... Zhang XY, Jiao GQ, Hurtig M, et al. title Expression pattern of apolipoprotein M during mouse and human ... Xu N, Nilsson Ehle P, Ahr n B title Correlation of apolipoprotein M with leptin and cholesterol ... Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 ... in the proximal promoter region of apolipoprotein M gene apoM confer the susceptibility to development ... O, et al. title Isolation and characterization of human apolipoprotein M containing lipoproteins ... of apolipoprotein M isoforms in low density lipoprotein journal J. Proteome Res. volume 5 issue 10 ... al. title Effects of ischemia reperfusion injury on apolipoprotein M expression in the liver journal ... binding properties of the human lipocalin apolipoprotein M journal J. Lipid Res. volume 48 issue 8 ... more details
protein Name apolipoprotein A I binding protein caption image width HGNCid 18453 Symbol APOA1BP AltSymbols EntrezGene 128240 OMIM 608862 RefSeq NM 144772 UniProt Q8NCW5 PDB ECnumber Chromosome 1 Arm q Band 21 LocusSupplementaryData Apolipoprotein A I binding protein also known as APOA1BP is a protein that in humans is encoded by the APOA1BP gene . ref name pmid11991719 cite journal author Ritter M, Buechler C, Boettcher A, Barlage S, Schmitz Madry A, Ors E, Bared SM, Schmiedeknecht G, Baehr CH, Fricker G, Schmitz G title Cloning and characterization of a novel apolipoprotein A I binding protein, AI BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA I journal Genomics volume 79 issue 5 pages 693 702 year 2002 month May pmid 11991719 doi 10.1006 geno.2002.6761 url ref Function APOA1BP binds to APOA1 , APOA2 , and high density lipoprotein HDL . ref name pmid11991719 In addition, APOA1BP appears to play a role in capacitation sperm capacitation . ref name pmid18202122 cite journal author Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC title Biochemical and Structural Characterization of Apolipoprotein A I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation journal Endocrinology volume 149 issue 5 pages 2108 20 year 2008 month May pmid 18202122 pmc 2329272 doi 10.1210 en.2007 0582 url ref References Reflist gene 1 stub ... more details
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