- Argatroban
m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey KXNPVXPOPUZYGB VSVYTNTFSA N Argatroban ..., argatroban was licensed by the Food and Drug Administration FDA for prophylaxis or treatment of thrombosis ... it. Argatroban is given intravenously and drug plasma concentrations reach steady state in 1 3 hours. ref name test Dhillon S. Argatroban A Review of its Use in the Management of Heparin Induced ... articleviewer.aspx?year 2009&issue 09040&article 00005&type abstract Link text ref Argatroban is metabolized ... . Transitioning to warfarin in individuals with heparin induced thrombocytopenia Argatroban is used ... normalized ratio INR caused by argatroban. The combination of argatroban and warfarin may raise the INR ... cite journal author Hursting MJ, Lewis BE, Macfarlane DE. title Transitioning from argatroban ... that the INR will be therapeutic 2 3 when the argatroban is discontinued. References references External links http www.argatroban.com GlaxoSmithKline s website on argatroban Antithrombotics Category Direct thrombin inhibitors Category Guanidines Category Sulfonamides de Argatroban pt Argatrobana ... more details
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- List of drugs: Aq-Ar
List of drugs A Aq Ar aq Aqua Lube Plus Aquacare Aquacort Aquamephyton Aquaphyllin Aquasol A Aquatag AquaTar Aquatensen Aquazide H ar ara arf ARA C Aralast Aralen Aramine Aranesp Amgen aranidipine International Nonproprietary Name INN aranotin International Nonproprietary Name INN araprofen International Nonproprietary Name INN arasertaconazole International Nonproprietary Name INN Arava arbaclofen placarbil United States Adopted Name USAN , International Nonproprietary Name INN arbaprostil International Nonproprietary Name INN arbekacin International Nonproprietary Name INN arbutamine International Nonproprietary Name INN Arcalyst Arcet arcitumomab International Nonproprietary Name INN arclofenin International Nonproprietary Name INN ardacin avoparcin International Nonproprietary Name INN ardenermin United States Adopted Name USAN ardeparin sodium International Nonproprietary Name INN Arduan Aredia Aredia Novartis Arestin Arestocaine hcl arfalasin International Nonproprietary Name INN arfendazam International Nonproprietary Name INN Arfonad arg ars Argatroban argatroban International Nonproprietary Name INN Argesic SA argimesna International Nonproprietary Name INN arginine International Nonproprietary Name INN argipressin International Nonproprietary Name INN argiprestocin International Nonproprietary Name INN Argyrol S.S. arhalofenate United States Adopted Name USAN , International Nonproprietary Name INN Aricept arildone International Nonproprietary Name INN Arimidex AstraZeneca aripiprazole International Nonproprietary Name INN Aristocort Aristogel Aristospan Arixtra Arlex Arlidin armodafinil United States Adopted Name USAN Armour Thyroid arnolol International Nonproprietary Name INN arofylline International Nonproprietary Name INN Aromasin Pharmacia & Upjohn Company aronixil International Nonproprietary Name INN arotinolol International Nonproprietary Name INN arprinocid International Nonproprietary Name INN arpromidine International Nonproprietary Name INN Ar ... more details
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- Direct thrombin inhibitor
Direct thrombin inhibitors DTIs are a class of medication that act as anticoagulant s delaying coagulation blood clotting by directly inhibiting the enzyme thrombin . Some are in clinical use, while others are undergoing clinical development. Several members of the class are expected to replace heparin and derivatives and warfarin in various clinical scenarios. Types There are two types of DTIs, dependent on their interaction with the thrombin molecule. Bivalent DTIs hirudin and analogs bind both to the active site and exosite 1, while univalent DTIs bind only to the active site. ref name DiNisio cite journal author Di Nisio M, Middeldorp S, B ller H title Direct thrombin inhibitors. journal N Engl J Med volume 353 issue 10 pages 1028 40 year 2005 pmid 16148288 doi 10.1056 NEJMra044440 ref Bivalent Hirudin and derivatives were originally discovered in Hirudo medicinalis Hirudin Bivalirudin transient inhibition is cleaved by thrombin Lepirudin Desirudin Univalent Univalent DTIs include Argatroban Melagatran and its prodrug ximelagatran Dabigatran Uses Bivalent DTIs enjoy limited use in circumstances where heparin would be indicated such as the acute coronary syndrome unstable angina , but cannot be used. As they are administered by injection intravenous , intramuscular or subcutaneous , they are less suitable for long term treatment. ref name DiNisio Argatroban as well as the hirudins are used for heparin induced thrombocytopenia , a rare but serious complication of heparin treatment that requires anticoagulation as it increases both arterial and venous thrombosis risk but not with the putative agent, heparin. ref name DiNisio Ximelagatran showed good efficacy compared with warfarin in several trials in prevention and treatment of deep vein thrombosis and as thromboprophylaxis in atrial fibrillation . ref name DiNisio Development was stopped by manufacturer AstraZeneca , however, because of reports of liver enzyme derangements and liver failure . ref cite press relea ... more details
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- ATC code B01
ATC codes lead B 01 Antithrombotic agents anchor B01A B01A Antithrombotic agents anchor B01AA B01AA Vitamin K antagonists B01AA01 Dicoumarol B01AA02 Phenindione B01AA03 Warfarin B01AA04 Phenprocoumon B01AA07 Acenocoumarol B01AA08 Ethyl biscoumacetate B01AA09 Clorindione B01AA10 Diphenadione B01AA11 Tioclomarol B01AA12 Fluindione anchor B01AB B01AB Heparin group B01AB01 Heparin B01AB02 Antithrombin III B01AB04 Dalteparin B01AB05 Enoxaparin B01AB06 Nadroparin B01AB07 Parnaparin B01AB08 Reviparin B01AB09 Danaparoid B01AB10 Tinzaparin B01AB11 Sulodexide B01AB12 Bemiparin B01AB51 Heparin, combinations anchor B01AC B01AC Platelet aggregation inhibitors excluding heparin B01AC01 Ditazole B01AC02 Cloricromen B01AC03 Picotamide B01AC04 Clopidogrel B01AC05 Ticlopidine B01AC06 Acetylsalicylic acid B01AC07 Dipyridamole B01AC08 Carbasalate calcium B01AC09 Epoprostenol B01AC10 Indobufen B01AC11 Iloprost B01AC13 Abciximab B01AC15 Aloxiprin B01AC16 Eptifibatide B01AC17 Tirofiban B01AC18 Triflusal B01AC19 Beraprost B01AC21 Treprostinil B01AC22 Prasugrel B01AC23 Cilostazol B01AC24 Ticagrelor B01AC30 Combinations B01AC56 Acetylsalicylic acid and esomeprazole anchor B01AD B01AD Enzymes B01AD01 Streptokinase B01AD02 Alteplase B01AD03 Anistreplase B01AD04 Urokinase B01AD05 Fibrinolysin B01AD06 Brinase B01AD07 Reteplase B01AD08 Saruplase B01AD09 Ancrod B01AD10 Drotrecogin alfa activated B01AD11 Tenecteplase B01AD12 Protein C anchor B01AE B01AE Direct thrombin inhibitors B01AE01 Desirudin B01AE02 Lepirudin B01AE03 Argatroban B01AE04 Melagatran B01AE05 Ximelagatran B01AE06 Bivalirudin B01AE07 Dabigatran etexilate anchor B01AX B01AX Other antithrombotic agents B01AX01 Defibrotide B01AX04 Dermatan sulfate B01AX05 Fondaparinux B01AX06 Rivaroxaban References Reflist Antithrombotics Category ATC codes B01 ca Codi ATC B01 cs ATC k d B01 es Anexo C digo ATC B01 ko ATC B01 hu ATC B01 Tromb zis kezel s re haszn latos szerek pl ATC B01 ro Cod ATC B01 sr ATC kod B01 sv ATC kod B01 Antikoagulantia t ... more details
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- Heparin-induced thrombocytopenia
Treatment Image Argatroban.svg right thumb Molecular structure of argatroban, a direct thrombin ... in patients with strongly suspected or proven HIT danaparoid , lepirudin , and argatroban . These are alternatives to heparin therapy. Not all agents are registered in all countries. For instance, argatroban ... and 0.42 when compared to patient controls. In addition, patients treated with argatroban for HIT showed ... more details
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- Lepirudin
J title A comparison of lepirudin and argatroban outcomes. journal Clin Appl Thromb Hemost volume ... more details
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- Anticoagulant
drugs argatroban and dabigatran . An oral direct thrombin inhibitor, ximelagatran Exanta was denied ... more details
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- Extracorporeal membrane oxygenation
D, Han Y, Custer J et al. title A case series describing the use of argatroban in patients on extracorporeal ... more details
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- Thrombocytopenia
such as lepirudin or argatroban , which are approved by the Food and Drug Administration United States ... more details
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- Ventricular assist device
2008 month day title Argatroban as a Primary or Secondary Postoperative Anticoagulant in Patients Implanted ... more details
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