- Arsphenamine
Image Salvarsan montage.png thumb right 300px right The structure of Arsphenamine has been proposed to be akin to the azobenzene A , but mass spectral studies published in 2005 suggest it is actually a mixture of the trimer B and the pentamer C . Arsphenamine , also known as Salvarsan and 606 , is a medication drug that was used beginning in the 1910s to treat syphilis and African trypanosomiasis trypanosomiasis . reference for trypanosomiasis not included here as a better one will be found ... Karen H. Antman, The History of Arsenic Trioxide in Cancer Therapy, The Oncologist, Vol. 6, Suppl 2, 1 2, April 2001 It is an organoarsenic compound , and was the first modern Chemotherapy chemotherapeutic agent . History Sahachiro Hata discovered the antisyphilitic activity of this compound in 1909 in the laboratory of Paul Ehrlich , during a survey of hundreds of newly synthesized organic arsenic al compounds. Ehrlich had theorized that by screening many compounds, a drug could be discovered with antimicrobial activity. Ehrlich s team began their search for such a magic bullet among chemical derivatives of the dangerously toxic drug atoxyl . This was the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications, the basis for nearly all modern pharmaceutical research. Arsphenamine was originally called 606 because it was the sixth in the sixth group of compounds synthesized for testing it was marketed by Hoechst AG under the trade name Salvarsan in 1910. ref name acs cite web url http pubs.acs.org cen coverstory 83 8325 8325salvarsan.html title Salvarsan accessdate 2010 02 01 quote publisher Chemical & Engineering News ref ref In Germany, it was the practice to designate compounds by their development number. Another compound known commonly in Germany by its number is parathion , which was the 605th compound to be developed ... . Arsphenamine is not toxic to spirochetes until it has been converted to an active form by the body ... more details
|
- Arsenical
An arsenical is a arsenic containing compound. ref MeshName Arsenicals ref Examples include arsanilic acid arsenamide arsenates arsenites arsphenamine p azobenzenearsonate cacodylic acid melarsoprol roxarsone References reflist chemistry stub Category Arsenic compounds ... more details
|
- Abelin reaction
Image Neosalvarsan.svg thumb Neosalvarsan The Abelin reaction is a qualitative reaction for demonstrating the presence of arsphenamine and neoarsphenamine in blood and urine . It is named for Issak Abelin , Swiss physiologist. ref WhoNamedIt synd 131 ref References reflist Eponymous medical signs for infectious disease Category Blood tests med diagnostic stub ... more details
|
- Joseph Igersheimer
Orphan date February 2009 Infobox scientist name PAGENAME image Replace this image male.svg image size 150px caption PAGENAME birth date 1879 birth place death date 1965 death place residence citizenship nationality Germany ethnicity field Ophthalmology work institutions Tufts University alma mater doctoral advisor doctoral students known for arsphenamine for the treatment of syphilis author abbrev bot author abbrev zoo influences influenced prizes religion footnotes signature Joseph Igersheimer 1879&ndash 1965 was a German born ophthalmology ophthalmologist known for his work on arsphenamine for the treatment of syphilis . References cite journal last Namal first Arin authorlink coauthors Reisman A. year 2007 month November title Joseph Igersheimer 1879 1965 a visionary ophthalmologist and his contributions before and after exile journal Journal of medical biography volume 15 issue 4 pages 227 34 publisher location England issn 0967 7720 pmid 18172563 bibcode oclc id url language format accessdate laysummary laysource laydate quote cite journal last Sloane first A E authorlink year 1969 month November title Biographical sketch of Josef Igersheimer journal Survey of Ophthalmology volume 14 issue 3 pages 174 5 publisher location UNITED STATES issn 0039 6257 pmid 4902158 bibcode oclc id url language format accessdate laysummary laysource laydate quote Persondata Metadata see Wikipedia Persondata . NAME Igersheimer,Josef ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1879 PLACE OF BIRTH DATE OF DEATH 1965 PLACE OF DEATH DEFAULTSORT Igersheimer,Josef Category 1879 births Category 1965 deaths Category German physicians Category German ophthalmologists Category Tufts University faculty Germany med bio stub ... more details
|
- Sahachiro Hata
Japanese name Hata Infobox scientist name Sahachir Hata image Elrich and Hata.jpg image size alt caption Dr Paul Ehrlich & Dr Hata Sahachir birth date birth date 1873 03 23 mf y birth place Masuda, Shimane , Japan death date death date and age 1938 11 22 1873 03 23 death place residence citizenship nationality ethnicity fields workplaces alma mater doctoral advisor academic advisors doctoral students notable students known for Arsphenamine influences influenced awards footnotes Image Hata Sahachiro.jpg thumb right 200px Doctor Hata bronze Bust sculpture bust , at Hata Memorial Museum in Shimane prefecture . nihongo Sahachir Hata Hata Sahachir extra March 23, 1873 November 22, 1938 was a Japan Japanese bacteriologist who developed the Arsphenamine drug in 1909 in the laboratory of Paul Ehrlich . Hata was born in Tsumo Village, Mino District, Shimane now part of Masuda, Shimane Masuda City , and completed his medical education in Kyoto . He studied epidemic diseases under the famous Dr Kitasato Shibasabur at Kitasato University Kitasato s Institute for the Study of Infectious Diseases in Tokyo , and later studied immunology at the Robert Koch Institute in Berlin . While in Germany , he took the opportunity to learn about chemotherapy at the German National Institute for Experimental Therapeutics in Frankfurt , where he assisted Paul Ehrlich in the discovery of arsphenamine, which proved effective in curing syphilis . It was called Salvarsan 606 because it was the 606th drug that Ehrlich tried. After his return to Japan, he helped found the Institute now Kitasato University , of which he became a director. He also lectured at Keio University . References Low, Morris. Building a Modern Japan Science, Technology, and Medicine in the Meiji Era and Beyond . Macmillan Publishers Palgrave Macmillan 2005 . ISBN 1 4039 6832 2 Porter, Roy. Blood and Guts A Short History of Medicine . W. W. Norton & Company Reprint edition June 2004 . ISBN 0 393 32569 5 Waller, John. ... more details
|
- Timeline of antibiotics
Unreferenced date December 2009 This is the timeline of antimicrobial anti infective therapy. The years show when a given drug was released onto the pharmaceutical market. This is not a timeline of the development of the antibiotics themselves. 1910 Arsphenamine aka Salvarsan 1912 Neosalvarsan 1935 Prontosil an oral precursor to sulfanilimide 1936 Sulfanilimide 1938 Sulfapyridine M&B 693 1939 sulfacetamide 1940 sulfamethizole 1942 benzylpenicillin 1942 gramicidin S 1942 sulfadimidine 1943 sulfamerazine 1944 streptomycin 1947 sulfadiazine 1948 chlortetracycline 1949 chloramphenicol 1949 neomycin 1950 oxytetracycline 1950 penicillin G procaine 1952 erythromycin 1954 benzathine penicillin 1955 spiramycin 1955 tetracycline 1955 thiamphenicol 1955 vancomycin 1956 phenoxymethylpenicillin 1958 colistin 1958 demeclocycline 1959 virginiamycin 1960 methicillin 1960 metronidazole 1961 ampicillin 1961 spectinomycin 1961 sulfamethoxazole 1961 trimethoprim 1962 cloxacillin 1962 fusidic acid 1963 fusafungine 1963 lymecycline 1964 gentamicin 1966 doxacycline 1967 carbenicillin 1967 rifampicin 1968 clindamycin 1970 cefalexin 1971 cefazolin 1971 pivampicillin 1971 tinidazole 1972 amoxicillin 1972 cefradine 1972 minocycline 1972 pristinamycin 1973 fosfomycin 1974 talampicillin 1975 tobramycin 1975 bacampicillin 1975 ticarcillin 1976 amikacin 1977 azlocillin 1977 cefadroxil 1977 cefamandole 1977 cefoxitin 1977 cefuroxime 1977 mezlocillin 1977 pivmecillinam 1979 cefaclor 1980 cefmetazole 1980 cefotaxime 1980 cefsulodin 1980 piperacillin 1981 amoxicillin clavulanic acid co amoxiclav 1981 cefperazone 1981 cefotiam 1981 cefsulodin 1981 latamoxef 1981 netelmicin 1982 apalcillin 1982 ceftriaxone 1982 micronomicin 1983 cefmenoxime 1983 ceftazidime 1983 ceftiroxime 1983 norfloxacin 1984 cefonicid 1984 cefotetan 1984 temocillin 1985 cefpiramide 1985 imipenem cilastatin 1985 ofloxacin 1986 mupirocin 1986 aztreonam 1986 cefoperazone sulbactam 1986 ticarcillin clavulanic acid 1987 ampicillin sulba ... more details
|
- Balanoposthitis
, used with peroxide powder and arsphenamine and, in severe cases, a dorsal slit, was the extent ... more details
|
- Paul Ehrlich
toxic version of the medicament. In 1909 he and his student Sahachiro Hata developed Arsphenamine Salvarsan ... his life and focuses on Arsphenamine Salvarsan arsphenamine , compound 606 , his cure for syphilis ... more details
|
- Dr. Ehrlich's Magic Bullet
called 606 , is now known as Arsphenamine or Salvarsan . The joy of discovery is short lived, as 38 ... more details
|
- 1910 in science
Year nav topic 1910 science The year 1910 in science and technology involved some significant events, listed below. Astronomy The earth passes through the tail of Comet Halley . Chemistry Albert Einstein and Marian Smoluchowski find the Einstein Smoluchowski formula for the attenuation coefficient due to density fluctuations in a gas. Umetaro Suzuki isolates the first vitamin complex, aberic acid . ref http www.journalarchive.jst.go.jp english jnlabstract en.php?cdjournal nikkashi1880&cdvol 32&noissue 1&startpage 4 Tokyo Kagaku Kaishi 1911 ref Hoechst AG market Arsphenamine under the trade name Salvarsan , the first organic antisyphilitic, its properties having been discovered the previous fall by bacteriologist Sahachiro Hata during systematic testing in the laboratory of Paul Ehrlich it rapidly becomes the world s most widely prescribed drug. ref cite web url http pubs.acs.org cen coverstory 83 8325 8325salvarsan.html title Salvarsan accessdate 2010 02 01 work Chemical & Engineering News year 2005 publisher American Chemical Society accessdate 2011 12 31 ref Mathematics Publication of the 1st volume of Principia Mathematica by Alfred North Whitehead and Bertrand Russell , one of the most important and seminal works in mathematical logic and philosophy. First known use of the term Econometrics in cognate form , by Pawe Ciompa . ref cite book first M. Hashem last Pesaran authorlink M. Hashem Pesaran year 1987 chapter Econometrics title The New Palgrave A Dictionary of Economics volume 2 pages 8 22 ref Physics German people German physicist Theodor Wulf climbs the Eiffel Tower with an electrometer and discovers the first evidence of cosmic rays . Hans Reissner and Gunnar Nordstrom Gunnar Nordstr m define the Reissner Nordstr m Gravitational singularity singularity Hermann Weyl solves the special case for a point body source. Physiology and medicine July 15 Publication of the eighth edition of Emil Kraepelin s Psychiatrie Ein Lehrbuch f r Studierende und Arzte , nami ... more details
|
- History of neurology
was Arsphenamine salvarsan for syphilis , followed by the induction of fever in neurosyphilis . The treatment ... more details
|
- Poikiloderma vasculare atrophicans
containing arsenic , such as arsphenamine , has also been suggested as a least common cause. ref ... more details
|
- August 1909
ref Paul Ehrlich found the first successful treatment for syphilis , arsphenamine , on his ... 606 would become the slang name for the treatment with Salvarsan , the trade name for arsphenamine ... more details
|
- List of antibiotics
Antituberculosis Neurotoxicity , ototoxicity As other aminoglycosides colspan 5 Others Arsphenamine ... more details
|
- History of syphilis
were found. An antimicrobial used for treating disease was the arsenic organo arsenical drug Arsphenamine ... more details
|
- Organic chemistry
2012 The first time a drug was systematically improved was with arsphenamine Salvarsan . Though numerous ... more details
|
- Arsenic
, including arsphenamine by Paul Ehrlich and arsenic trioxide by Thomas Fowler inventor Thomas Fowler . Arsphenamine as well as neosalvarsan was indicated for syphilis and trypanosomiasis , but has ... more details
|
- List of MeSH codes (D02)
For other categories, see List of MeSH codes . This is the fourth part of the list of the D codes for MeSH . It is a product of the United States National Library of Medicine . Source for content is http www.nlm.nih.gov mesh filelist.html here . File 2006 MeSH Trees . MeshNumber D02 Organic Chemicals organic chemical s MeshNumber D02.033 Alcohols alcohol s MeshNumber D02.033.100 Amino Alcohols amino alcohol s MeshNumber D02.033.100.291 Ethanolamines ethanolamine s MeshNumber D02.033.100.291.057 Albuterol salbutamol albuterol MeshNumber D02.033.100.291.211 Choline choline MeshNumber D02.033.100.291.211.500 Platelet Activating Factor platelet activating factor MeshNumber D02.033.100.291.231 Clenbuterol clenbuterol MeshNumber D02.033.100.291.274 Deanol deanol MeshNumber D02.033.100.291.310 Epinephrine epinephrine MeshNumber D02.033.100.291.375 Ethanolamine ethanolamine MeshNumber D02.033.100.291.410 2 Hydroxyphenethylamine 2 hydroxyphenethylamine MeshNumber D02.033.100.291.439 Isoproterenol isoproterenol MeshNumber D02.033.100.291.460 Labetalol labetalol MeshNumber D02.033.100.291.480 Midodrine midodrine MeshNumber D02.033.100.291.502 Norepinephrine norepinephrine MeshNumber D02.033.100.291.502.651 Normetanephrine normetanephrine MeshNumber D02.033.100.291.525 Octopamine octopamine MeshNumber D02.033.100.291.550 Orciprenaline orciprenaline MeshNumber D02.033.100.291.550.300 Fenoterol fenoterol MeshNumber D02.033.100.291.617 Phenylephrine phenylephrine MeshNumber D02.033.100.291.617.300 Etilefrine etilefrine MeshNumber D02.033.100.291.630 Procaterol procaterol MeshNumber D02.033.100.291.805 Sotalol sotalol MeshNumber D02.033.100.291.870 Synephrine synephrine MeshNumber D02.033.100.291.905 Terbutaline terbutaline MeshNumber D02.033.100.350 Heptaminol heptaminol MeshNumber D02.033.100.400 Isoetharine isoetharine MeshNumber D02.033.100.624 Propanolamines propanolamines MeshNumber D02.033.100.624.025 Acebutolol acebutolol MeshNumber D02.033.100.624.058 Alprenolol alprenolol ... more details
|
- Chemotherapy
of antibiotic s antibacterial chemotherapy . The first modern chemotherapeutic agent was arsphenamine ... more details
|
- Tuskegee syphilis experiment
studied for six to eight months and then treated with contemporary methods including Arsphenamine Salvarsan ... more details
|
- John R. Brinkley
at 25 a shot formatnum Inflation US 25 1910 r 2 in current value , telling them it was Arsphenamine ... more details
|
- Hepatitis B
Arsphenamine Salvarsan for the treatment of syphilis . The virus was not discovered until ... more details
|
- Sexually transmitted disease
to arrest suspected prostitutes. The first effective treatment for a sexually transmitted disease was Arsphenamine ... more details
|
- Antibacterial
ref name Bosch2008 now called Arsphenamine. In 1895, Vincenzo Tiberio, physician of the University ... more details
|
- Medicine
Jenner and Louis Pasteur . The first antibiotic was arsphenamine Salvarsan discovered by Paul Ehrlich ... more details
|
Encyclopedia
top
