Infobox Disease Name Arthralgia Image Caption DiseasesDB 15237 ICD10 ICD10 M 25 5 m 20 ICD9 ICD9 719.4 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D018771 Arthralgia from Greek arthro , joint algos , pain literally means joint pain ref name medterms arthralgia cite web url http www.medterms.com script main art.asp?articlekey 2343 title Arthralgia Definition accessdate 2007 09 20 work MedicineNet.com ref ref name jgh arthralgia cite web url http www.ncbi.nlm.nih.gov books bv.fcgi?indexed google&rid cm.chapter.4738 title Arthralgia author Joe G. Hardin accessdate 2007 09 20 work Clinical Methods The History, Physical, and Laboratory Examinations ref it is a symptom of injury , infection , illness es in particular arthritis or an allergic reaction to medication . ref name drugReaction cite web url http www.ncbi.nlm.nih.gov books bv.fcgi?highlight arthralgia&rid cm.chapter.5910 5949 title Allergic Drug Reactions Systemic Allergic Drug Reactions author James R Philp accessdate 2007 09 20 work Clinical Methods The History, Physical, and Laboratory Examinations ref According to Medical Subject Headings MeSH , the term arthralgia should only be used when the condition is non inflammatory, and the term arthritis should be used when the condition is inflammation inflammatory . ref ... and performing physical exam s. When attempting to establish the cause of the arthralgia, the emphasis is on the interview. ref name jgh arthralgia The patient is asked questions intended to narrow ... es or a history of seizure s. ref name jgh arthralgia ref name spondyl table1 cite web url http ... the appropriate exams and lab tests. The causes of arthralgia are varied and range, from a joints ... Vaccine, Recombinant GARDASIL , to include arthralgia, myalgia, asthenia, fatigue, and malaise in the Adverse ... of arthralgia class wikitable sortable Cause Monoarticular Mono or br polyarticular Speed of onset ... cause of the arthralgia . Pain management may include stretching exercises, over the counter pain ... more details
Meltzer s triad describes the classical symptoms suggesting the diagnosis of cryoglobulinaemia of polyclonal CGs seen in essential , viral , or connective tissue disease associated cryoglobulinaemia. ref http www.patient.co.uk doctor Cryoglobulinaemia.htm ref The triad consists of palpable purpura arthralgia joint pain weakness . References references Category Symptoms and signs Vascular ... more details
Gonococcemia also known as Arthritis dermatosis syndrome ref name Bolognia and Disseminated gonococcal infection ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref is a condition characterized by a hemorrhagic vesiculopustular eruption, bouts of fever , and arthralgia or actual arthritis of one or several joints. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 277 See also Primary gonococcal dermatitis List of cutaneous conditions References reflist Cutaneous infection stub Category Bacterium related cutaneous conditions ... more details
Wikify date September 2011 Topical irritation agents Some agents Mustard plaster sinapism Refined terebenthine oil Menthol Ammonia Indications Respiratory diseases Sinapism , Terebenthine , Menthol Angina pectoris Sinapism , Menthol Neuralgia Sinapism , Terebenthine , Menthol Myalgia Sinapism , Terebenthine , Menthol Arthralgia Terebenthine , Menthol Migraine Menthol pencil, friction in temporal area Inhale in lipothymia or ebriety Ammonia Antiseptic Ammonia Mechanism of action Revulsive action in CNS interfere 2 flows of excitation from affected viscera and from the surface of the skin and visceral afferences decrease in intensity. Amelioration of trophic status due to cutaneo visceral reflexes and histamine release the skin becomes hyperemic reflectory dilation of arterioles and capillaries due to axon reflexes and edematous vasodilation and increase of permeability due to histamine release . Sources Pharmacology 9th ed., Harkervich D.A., ISBN 5 9704 0264 8, Geothar Media,2006 Category Traditional medicine alt med stub ... more details
Taxobox virus group iv familia Togaviridae genus Alphavirus Babanki virus BBKV is a member of the virus family Togaviridae of Class IV of the Baltimore classification Baltimore classification system and the genus Alphavirus . Genome and Structure It has an unsegmented, positive sense, single stranded RNA genome which is approximately 11.7kb long. In general, members of the Togaviridae have genomes which are able to be used directly as mRNA and the genome of BBKV can code for both structural and non structural proteins. Currently, the genome of BBKV has only been partially sequenced. It has a spherical nucleocapsid which is approximately 40 nm in diameter and shows icosahedral symmetry of T 4. This nucleocapsid core is surrounded by a lipid envelope covered with glycoprotein spikes and virion particles are approximately 70 nm in diameter in total http phene.cpmc.columbia.edu ICTVdB 73001B24.htm . Disease BBKV was first isolated in Babanki in Northwest Cameroon , Africa in 1969 http phene.cpmc.columbia.edu ICTVdB 73001B24.htm and the disease is also known in Senegal and Madagascar http bugsmart.com.au content view 22 51 . It is closely related to another Alphavirus , Sindbis virus and causes similar symptoms in humans like fever, arthralgia or joint pain and a rash. It is spread by an arthropod vector, typically mosquito es of the genus Culex and in this way, may be described as an Arbovirus http www.diseasesdatabase.com ddb32204.htm . Its normal host is birds http www.online medical dictionary.org Babanki virus.asp?q Babanki virus . References ICTVdB The Universal Virus Database , version 3. http www.ncbi.nlm.nih.gov ICTVdb ICTVdB Category Togaviruses ... more details
Pentavalent antimonials also abbreviated pentavalent Sb or Sb sup V sup are a group of compounds used for the treatment of leishmaniasis . They are also called pentavalent antimony compounds . Types The first pentavalent antimonial used was urea stibamine first introduced in the 1930s, it fell out of favour in the 1950s due to higher toxicity compared to sodium stibogluconate . The compounds currently available for clinical use are sodium stibogluconate Pentostam manufactured by GlaxoSmithKline available in United States and UK , which is administered by slow intravenous injection. meglumine antimoniate Glucantim manufactured by Aventis available in Brazil , France and Italy , which is administered by intramuscular or intravenous injection. ref Lima EB, Porto C, Motta JCO, Sampaio RNR.Treatment of American cutaneous leishmaniasis. An Bras Dermatol. 2007 82 2 111 24. ref The pentavalent antimonials can only be given by injection there are no oral preparations available. Alternatives In many countries, widespread resistance to antimony has meant that amphotericin or miltefosine are now used in preference. ref cite journal title Treatment options for visceral leishmaniasis a systematic review of clinical studies done in India, 1980 2004 journal Lancet Infect Dis volume 5 issue 12 pages 763 774 author Olliaro P, Guerin P, Gerstl S, doi 10.1016 S1473 3099 05 70296 6 year 2005 pmid 16310148 display authors 2 ref Side effects Cardiotoxicity , reversible renal failure , pancreatitis , anemia , leukopenia , rash , headache , abdominal pain , nausea , vomiting , arthralgia , myalgia , thrombocytopenia , and transaminase elevation. References references Excavata antiparasitics Category Antiprotozoal agents Category Antimony compounds antiinfective drug stub ... more details
Anadin is a brand of painkiller sold in the United Kingdom UK and Ireland may be marketed elsewhere too by Wyeth . ref http www.wyeth.co.uk Home ConsumerProducts tabid 136 Default.aspx ref Several different types of painkiller are sold under the brand. ref http www.anadin.co.uk ref As of 2009 04 , these include Anadin Original aspirin and caffeine based Anadin paracetamol tablets launched in 1988 Anadin ibuprofen tablets launched in 1997 Anadin Extra aspirin, paracetamol and caffeine based ordinary version launched in 1983 and soluble version in 1992 Anadin Arthralgia Joint Pain Anadin Liquifast or Anadin Ultra ibuprofen based liquid capsules ordinary and Double strength versions ref http www.brandrepublic.com InDepth Features 188772 Superbrands case studies Anadin Superbrands case studies Anadin ref Criticism Along with other brands, Anadin s paracetamol tablets have been criticised for being overpriced compared to non branded versions e.g. 16 Anadin Paracetamol tablets each containing 500mg of paracetamol cost around 2.09 while non branded equivalents retail for around 0.35 . Over the past five years Anadin sales have dropped significantly with people favouring purchase of non branded versions and the Nurofen brand of painkillers which has seen increased sales due to marketing ref http www.dailymail.co.uk money article 1249869 Marketing push pays Nurofen maker Reckitt.html ref . As with many proprietary painkillers, the addition of caffeine to Anadin products may also make them slightly addictive or even induce headaches once people stop taking them. ref http www.independent.co.uk life style health and wellbeing features the great medicine ripoff 808919.html?r RSS The Independent The great medicine rip off ref In popular culture Anadin is mentioned in the song Harry May by the Oi band, The Business . Anadin is mentioned in the song New York by the punk rock band, Sex Pistols . It s one of the songs included in Never Mind the Bollocks, Here s the Sex Pistols album. ... more details
RR&BF Symptoms Symptoms of the disease may vary widely in severity, but major indicators are arthralgia ... arthralgia at 3 months. Arthralgias have resolved in the majority by 5 7 months. The incidence of chronic ... arthritis arthralgia which is similar to human disease. The disease in mice is characterized by an inflammatory ... more details
rash , fever, malaise, conjunctivitis , and arthralgia . The first well documented case of Zika virus ... States of Micronesia . This virus was characterized by rash, conjunctivitis, and arthralgia, and was initially ... more details
Infobox Disease Name Renal osteodystrophy Image Caption DiseasesDB ICD10 ICD10 N 25 0 n 25 ICD9 ICD9 588.0 ICDO OMIM MedlinePlus eMedicineSubj radio eMedicineTopic 500 MeshID D012080 Renal osteodystrophy or chronic kidney disease mineral and bone disorder ref name pmid19222724 cite journal author Sv ra F title Chronic kidney disease mineral and bone disorder CKD MBD a new term for a complex approach journal J Ren Care volume 35 Suppl 1 issue pages 3 6 year 2009 month March pmid 19222724 doi 10.1111 j.1755 6686.2009.00067.x url ref is a bone pathology , characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease . Renal osteodystrophy can be further divided into metabolic states associated with either high or low bone turnover. Signs and symptoms Renal osteodystrophy may exhibit no symptoms if it does show symptoms, they include Bone pain Arthralgia Joint pain Bone deformation Bone fracture Diagnosis Renal osteodystrophy is usually diagnosed after treatment for Chronic kidney disease end stage renal disease begins. Blood tests will indicate decreased calcium and calcitriol and increased phosphate and parathyroid hormone . X rays will also show bone features of renal osteodystropy chondrocalcinosis at the knees and pubic symphysis , osteopenia and bone fractures but may be difficult to differentiate from other conditions. Pathogenesis Renal osteodystrophy is thought to be the result of hyperparathyroidism secondary to hyperphosphatemia combined with hypocalcaemia , both of which are due to decreased excretion of phosphate by the damaged kidney. Low activated vitamin D3 vitamin D sub 3 sub levels are a result of the damaged kidneys inability to convert vitamin D sub 3 sub into its active form, calcitriol , and result in further hypocalcaemia . Differential diagnosis To confirm diagnosis, renal osteodystrophy must be distinguished from osteoporosis Alk Phos and PO sub 4 sub ... more details
Infobox Disease Name Periodic fever syndrome Image Caption DiseasesDB 9836 ICD10 ICD9 ICD9 277.31 ICDO OMIM MedlinePlus eMedicineSubj article eMedicineTopic 952254 MeshID D056660 The periodic fever syndromes also known as autoinflammatory syndromes are a set of disorders, many of which are genetic disorders in which the mechanisms which initiate and control inflammation are disturbed, leading to uncontrolled inflammation throughout the body. The syndromes are diverse, but tend to cause fever, arthralgia joint pains , abdominal pain s and may lead to chronic complications such as amyloidosis . ref name pmid16093838 cite journal author Stojanov S, Kastner DL title Familial autoinflammatory diseases genetics, pathogenesis and treatment journal Curr Opin Rheumatol volume 17 issue 5 pages 586 99 year 2005 pmid 16093838 doi 10.1097 bor.0000174210.78449.6b ref Restated, autoinflammatory syndromes are a group of inherited disorders characterized by bouts of inflammatory skin lesions and periodic fevers. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 148 Periodic fever syndromes are medically distinct from immunodeficiency conditions, in which infections can occur frequently and induce fever. Individual periodic fever syndromes class wikitable Name OMIM Gene Familial Mediterranean fever FMF OMIM2 249100 MEFV Hyperimmunoglobulinemia D with recurrent fever HIDS . This is now along with mevalonic aciduria defined as a mevalonate kinase deficiency ref name pmid12861380 cite journal author Houten SM, Frenkel J, Waterham HR title Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation journal Cell. Mol. Life Sci. volume 60 issue 6 pages 1118 34 year 2003 pmid 12861380 doi 10.1007 s00018 003 2296 4 ref OMIM2 260920 MVK TNF receptor associated periodic syndrome TRAPS OMIM2 142680 TNFRSF1A Cryopyrin associated periodic syndrome CAPS Muckle W ... more details
Taxobox color violet name Sindbis virus image caption image virus group iv familia Togaviridae genus alphavirus species Sindbis virus Sindbis Virus SINV is a member of the Togaviridae family, in the alphavirus subfamily. The virus was first isolated in 1952 in Cairo , Egypt . The virus is transmitted by mosquitoes Culex spp. SINV causes sindbis fever in humans and the symptoms include arthralgia , rash and malaise . Sindbis fever is most common in South and East Africa , Egypt , Israel , Philippines and parts of Australia . Sindbis virus is an arbovirus u ar u thropod u bo u rne and is maintained in nature by transmission between vertebrate bird hosts and invertebrate mosquito vectors. Humans are infected with Sindbis virus when bitten by an infected mosquito. Recently SINV has been linked to Pogosta disease in Finland . ref name cdc Kurkela S, Manni T, Vaheri A, Vapalahti O. http www.cdc.gov ncidod eid vol10no5 03 0689.htm Causative agent of Pogosta disease isolated from blood and skin lesions , Emerg Infect Dis serial on the Internet . Published 2004 May. accessed 2007 10 16 ref Virus structure, genome and replication Sindbis viruses are enveloped particles with an icosahedral capsid . Its genome is a single stranded RNA approximately 11.7kb long. It has a 5 cap and 3 polyadenylated tail therefore serves directly as messenger RNA mRNA in a host cell. The genome encodes four non structural proteins at the 5 end and the capsid and two envelope proteins at the 3 end. This is characteristic of all Togaviruses . Replication is cytoplasmic and rapid. The genomic RNA is partially translated at the 5 end to produce the non structural proteins which are then involved in genome replication and the production of new genomic RNA and a shorter sub genomic RNA strand. This sub genomic strand is translated into the structural proteins. The viruses assemble at the host cell surfaces and acquire their envelope through budding . A Togavirus 5 plus strand cis regulatory element non ... more details
Infobox disease Name Serum sickness Image Caption DiseasesDB 11970 ICD10 ICD10 T 80 6 t 80 ICD9 ICD9 999.5 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 2105 MeshID D012713 Serum sickness in humans is a adverse drug reaction reaction to proteins in antiserum derived from a non human animal source. It is a type of hypersensitivity , specifically immune complex hypersensitivity type III . The term serum sickness like reaction SSLR is occasionally used to refer to similar illnesses that arise from the introduction of certain non protein substances. ref name pmid16504095 cite journal author Brucculeri M, Charlton M, Serur D title Serum sickness like reaction associated with cefazolin journal BMC Clin Pharmacol volume 6 pages 3 year 2006 pmid 16504095 pmc 1397863 doi 10.1186 1472 6904 6 3 url http www.biomedcentral.com 1472 6904 6 3 ref It was first characterized by Clemens von Pirquet and B la Schick in 1906. ref name pmid11231202 cite journal author Jackson R title Serum sickness journal J Cutan Med Surg volume 4 issue 4 pages 223 5 year 2000 month October pmid 11231202 doi url ref Causes Serum sickness can be developed as a result of exposure to antibody antibodies derived from animals. These serums are generally administered to prevent or treat an infection or envenomation . When the antiserum is given, the human immune system can mistake the protein s present for harmful antigen s. The body produces antibodies, which combine with these proteins to form immune complex es. These complexes can cause more reactions, and cause the symptoms detailed below. Serum sickness can also be caused by several medication drugs , notably penicillin based medicines. This results in hypocomplementemia , a low C3 level in serum. Symptoms Symptoms can take as long as fourteen days after exposure to appear, and may include signs and symptoms commonly associated with allergic reaction s or infections, such as rash es, itching, joint pain arthralgia , fever , and swollen lymph nod ... more details
. In 1943 several outbreaks of arthralgia and arthritis were described in the Northern Territory ... arthritis arthralgia which is similar to human disease. The disease in mice, similar to humans, is characterized ... more details
Infobox disease Name Hyperimmunoglobulinemia D with recurrent fever Image Mevalonic acid 2D skeletal.png Caption Mevalonic acid DiseasesDB 30161 ICD10 ICD9 ICDO OMIM 260920 MedlinePlus eMedicineSubj eMedicineTopic MeshID Hyperimmunoglobulinemia D with recurrent fever commonly abbreviated as HIDS is a periodic fever syndrome originally described in 1984 by the internist Jos van der Meer Prof. Jos van der Meer , ref name pmid6144826 cite journal author van der Meer JW, Vossen JM, Radl J, et al. title Hyperimmunoglobulinaemia D and periodic fever a new syndrome journal Lancet volume 1 issue 8386 pages 1087 90 year 1984 month May pmid 6144826 doi 10.1016 S0140 6736 84 92505 4 url ref then at Leiden University Leiden University Medical Centre Medical Centre . No more than 300 cases have been described worldwide. Features HIDS is one of a number of periodic fever syndrome s. It is characterised by attacks of fever , arthralgia , skin disease skin lesions including cyclical mouth ulcers, and diarrhea . Laboratory features include an acute phase response elevated C reactive protein CRP and Erythrocyte sedimentation rate ESR and markedly elevated IgD and often IgA , although cases with normal IgD have been described. ref name Drenth cite journal author Drenth JP, van der Meer JW title Hereditary periodic fever journal N. Engl. J. Med. volume 345 issue 24 pages 1748 57 year 2001 month December pmid 11742050 doi 10.1056 NEJMra010200 ref It has mainly been described in the Netherlands and France , although the international registry includes a number of cases from other countries. ref name Drenth The differential diagnosis includes fever of unknown origin , familial Mediterranean fever FMF and TNF receptor associated periodic syndrome familial Hibernian fever or TNF reception associated periodic syndrome TRAPS . ref name Drenth Cause Virtually all patients with the syndrome have mutations in the gene for mevalonate kinase , which is part of the HMG CoA reductase pathway , an i ... more details
Yunogo or Yunogo Onsen is a hot spring town located in Mimasaka, Okayama Mimasaka city of Okayama Prefecture , Japan . The waters of the Yunogo hot springs onsen in Japanese are a mixture of sodium chloride and calcium chloride , with the amount of discharge at 540L min. ref http okayama japan.jp en onsen onsen mimasaka yunogo.html ref The waters are said to have healing effects on those suffering from chronic digestive disorders, nerve pain, rheumatism, arthralgia, chronic feminine problems, and skin problems. ref http www.kifunosato.com eng onsen.html ref History File Yunogo2000.jpg thumb Yunogo2000 Statue of En nin in Yunogo Yunogo Onsen is known as Sagi no yu, or hot water of the heron sagi is the Japanese word for egret or heron because 1,200 years ago a Buddhist high priest named Ennin En nin houshi discovered an injured heron bathing its wounded leg in the waters of a hot spring in Yunogo. This is how the special healing powers of these waters were discovered, and they now have evolved into a spot where people come to relax and enjoy the waters. There is a statue of En nin with a Heron outside of the Yunogo Sagi Onsen kan, the public bathing public bathhouse created in the exact spot where the Heron s hot spring was discovered. ref http www.japan i.jp hotspring chugoku d8jk7l0000029n4f.html ref Events Night Time Cherry Blossom Watching Early April The night time cherry blossom watching bus tour to Tsuyama Castle Kakuzan Park. This is one of the best cherry blossom viewing spots in western Japan. bus 30 min. one way Koinobori carp streamer Early April to early May 30 koinobori are flown from the You ragi Bridge on the Yoshino River . Mimasaka Furusato Summer Festival, Firework Show Early July Many night vendor stalls open at the time of festival, alongside a firework show. Yu jinja Shrine Autumn Festival Middle of October Hoping for fertility, people carrying miniature shrines mikoshi and Danjiri Matsuri danjiri walk around the area in Yunogo. Decorative Illum ... more details
considered to comprise hypermobility together with other symptoms, such as myalgia and arthralgia ... Major criteria A Beighton score of 4 9 or more either current or historic Arthralgia for more ... if aged 50 Arthralgia 3 months in one to three joints or back pain 3 months , spondylosis, spondylolysis ... more details
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