An artificialtranscriptionfactor is an example of a Chimera protein chimeral protein , designed to target and modulate gene transcription. ref cite journal author Gommans W, Haisma H, Rots M title Engineering zinc finger protein transcription factors the therapeutic relevance of switching endogenous gene expression on or off at command journal J. Mol. Biol. volume 354 issue 3 pages 507 19 year 2005 pmid 16253273 url http www.rug.nl farmacie onderzoek basiseenheden therapeuticgenemodulation publicaties publicaties2004 2005 6.pdf doi 10.1016 j.jmb.2005.06.082 ref They are generally composed of a DNA binding domain specific to a certain sequence coupled to a modulatory domain which acts upon other transcription factors in order to alter the expression of a particular gene. It is also possible to downregulate expression of a gene by targeting the 5 untranslated region with a DNA binding domain that lacks a regulatory domain this will reduce transcription simply by blocking RNA polymerase progression along the DNA template. See also Therapeutic gene modulation Zinc finger Zinc finger protein transcriptionfactor Chimera protein Protein engineering References reflist Category Engineered proteins ... more details
In molecular biology and genetics , a transcriptionfactor sometimes called a sequence specific DNA binding factor is a protein that binds to specific DNA sequence s, thereby controlling the flow or transcription ... issue 5556 pages 813 8 year 2002 pmid 11823631 doi 10.1126 science.1066355 ref Transcriptionfactor ... promoter regions of DNA adjacent to the genes that they regulate. Depending on the transcriptionfactor ... proteins. The transcriptionfactor can either do this directly or recruit other proteins with this catalytic ... proteins to the transcriptionfactor DNA complex ref name pmid10322133 cite journal author ... factors called general transcriptionfactor s GTFs are necessary for transcription to occur. ref ... needed for cell fate determination and cellular differentiation . The Hox transcriptionfactor family ... url ref Another example is the transcriptionfactor encoded by the SRY Sex determining ... receptor transcriptionfactor Estrogen is secreted by tissues such as the ovary ovaries and placenta ... K title Regulation of transcriptionfactor activity during cellular aging journal Biochem. Cell ... and transcriptionfactor binding activity during cellular aging journal Biol. Signals volume 5 issue ... the production and thus activity of a transcriptionfactor. One interesting implication of this is that transcription ... factor acts as its own repressor If the transcriptionfactor protein binds the DNA of its ... low levels of a transcriptionfactor in a cell. Nuclear localization In eukaryote s, transcription ... and nuclear targeting regulation of transcriptionfactor activity by subcellular localisation ... binding able to influence where a transcriptionfactor is located within a cell but ligand binding can also affect whether the transcriptionfactor is in an active state and capable of binding ... cite journal author Bohmann D title Transcriptionfactor phosphorylation a link between signal transduction ... be partially unwrapped by thermal fluctuations allowing temporary access to the transcriptionfactor ... more details
In molecular biology , activating transcriptionfactor , ATF , is a class of AP 1 transcriptionfactor AP 1 transcriptionfactor dimers. ref name van Dam cite journal author van Dam H, Castellazzi M title Distinct roles of Jun Fos and Jun ATF dimers in oncogenesis journal Oncogene volume 20 issue 19 pages 2453 64 year 2001 pmid 11402340 doi 10.1038 sj.onc.1204239 ref Genes include ATF1 , Activating transcriptionfactor 2 ATF2 , ATF3 , ATF4 , ATF5 , ATF6 , and ATF7 . References references External links MeshName Activating Transcription Factors protein stub Oncogenes Transcription factors g1 Category Transcription factors es Factor de transcripci n activador ... more details
GATA transcriptionfactor s are a family of transcriptionfactor s characterized by their ability to bind to the DNA sequence GATA . ref name pmid8321208 cite journal author Ko LJ, Engel JD title DNA binding specificities of the GATA transcriptionfactor family journal Mol. Cell. Biol. volume 13 issue 7 pages 4011 22 year 1993 pmid 8321208 doi pmc 359950 ref Genes GATA1 see also Gene GATA1 GATA2 see also Gene GATA2 GATA3 see also Gene GATA3 GATA4 see also Gene GATA4 GATA5 see also Gene GATA5 GATA6 see also Gene GATA6 References Reflist External links MeshName GATA transcription factors biochem stub Transcription factors g2 Category Transcription factors es GATA ... more details
General transcription factors GTF s or basal transcription factors are protein transcriptionfactor s that assist an RNA polymerase in Transcription genetics transcription initiation and or transcription elongation of broad classes of genes. GTFs are intimately involved in the process of gene regulation, and most are required for life. Types In bacteria , transcription initiation requires an RNA polymerase and a single GTF sigma factor . In archaea and eukaryotes , transcription initiation requires an RNA polymerase and a set of multiple GTFs. The Transcription initiation by eukaryotic RNA polymerase II involves the following GTFsare ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue 1 pages 77 137 year 2000 pmid 11092823 doi 10.1146 annurev.genet.34.1.77 ref ref name pmidc cite journal author Orphanides G, Lagrange T, Reinberg D title The general transcription factors of RNA polymerase II journal Genes Dev. volume 10 issue 21 pages 2657 83 year 1996 pmid 8946909 doi 10.1101 gad.10.21.2657 ref TFIIA TFIIB TFIID TFIIE TFIIF TFIIH References Reflist External links MeshName General Transcription Factors Cell signaling Transcription factors g2 DEFAULTSORT General TranscriptionFactor Category Transcription factors genetics stub fr Facteur g n ral de transcription ja nl Basale transcriptiefactoren pl Og lne czynniki transkrypcyjne ... more details
Conceptdab COUP transcriptionfactor can refer to COUP TFI COUP TFII Short pages monitor This long comment was added to the page to prevent it being listed on Special Shortpages. It and the accompanying monitoring template were generated via Template Longcomment. Please do not remove the monitor template without removing the comment as well. Category Transcription factors ... more details
An octamer transcriptionfactor is a transcriptionfactor which binds to the ATTTGCAT sequence. ref cite journal author Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB title Characterization of chicken octamer binding proteins demonstrates that POU domain containing homeobox transcription factors have been highly conserved during vertebrate evolution journal Proc. Natl. Acad. Sci. U.S.A. volume 87 issue 3 pages 1099 103 year 1990 pmid 1967834 doi 10.1073 pnas.87.3.1099 pmc 53418 ref Examples include Oct 1 Gene POU2F1 Oct 2 Gene POU2F2 Oct 4 Oct 3 4 Gene POU5F1 POU3F1 Oct 6 Gene POU3F1 POU3F2 Oct 7 Gene POU3F2 Oct 8 Gene POU3F3 POU3F2 Oct 9 Gene POU3F4 POU2F3 Oct 11 Gene POU3F4 References references External links MeshName Octamer transcription factors Transcription factors g3 Category Transcription factors biochem stub ... more details
protein Name ets variant gene 5 ets related molecule caption image width HGNCid 3494 Symbol ETV5 AltSymbols ERM EntrezGene 2119 OMIM 601600 RefSeq NM 004454 UniProt P41161 PDB ECnumber Chromosome 3 Arm q Band 28 LocusSupplementaryData ERM transcription factor is a transcription factor generated in Sertoli cell s, which are found in the testes and play a crucial role in spermatogenesis . External links MeshName ERM protein, human MeshName ETV5 protein, human gene 3 stub Transcription factors g3 Category Transcription factors ... more details
RNA polymerase II, B TFIID transcriptionfactor associated, 170kDa Mot1 homolog, S. cerevisiae url http ... author Timmers HTM, Meyers RE, Sharp PA title Composition of transcriptionfactor B TFIID journal ... TAF15 TAFII68 See also Eukaryotic transcription GAAC element General transcriptionfactor Preinitiation complex Regulation of gene expression RNA polymerase II holoenzyme TATA Binding Protein Transcription genetics References Reflist External links MeshName TranscriptionFactor TFIID Cell signaling Transcription factors g2 Category Gene expression Category Molecular genetics Category Proteins Category Transcription factors Genetics stub de Transkriptionsfaktor IID es TFIID ... TBP . In a test tube, only TBP is necessary for transcription genetics transcription at promoter biology ... Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue pages 77 ... than 70 polypeptides required for initiation of transcription by RNA polymerase II, binds to the core ... of the transcription complex, and acts as a channel for regulatory signals. Subunits in the TFIID ... more details
protein Name GTF2H1 general transcriptionfactor IIH, polypeptide 1, 62kDa caption image width HGNCid 4655 Symbol GTF2H1 AltSymbols BTF2 EntrezGene 2965 OMIM 189972 RefSeq NM 005316 UniProt P32780 PDB ECnumber Chromosome 11 Arm p Band 15.1 LocusSupplementaryData p14 protein Name GTF2H2 general transcriptionfactor IIH, polypeptide 2, 44kDa caption image width HGNCid 4656 Symbol GTF2H2 AltSymbols BTF2, TFIIH, BTF2P44, T BTF2P44 EntrezGene 2966 OMIM 601748 RefSeq NM 001515 UniProt Q13888 PDB ECnumber Chromosome 5 Arm q Band 12.2 LocusSupplementaryData 13.3 protein Name general transcriptionfactor IIH, polypeptide 3, 34kDa caption image width HGNCid 4657 Symbol GTF2H3 AltSymbols BTF2, TFIIH EntrezGene 2967 OMIM 601750 RefSeq NM 001516 UniProt Q13889 PDB ECnumber Chromosome 12 Arm q Band 24.31 LocusSupplementaryData Transcriptionfactor II H TFIIH is one of several general transcriptionfactor s that make up the RNA polymerase II preinitiation complex . ref cite journal author Kim TK, Richard H. Ebright Ebright RH , Reinberg D title Mechanism of ATP dependent promoter melting by transcriptionfactor IIH journal Science volume 288 issue 5470 pages 1418 22 year 2000 pmid 10827951 doi 10.1126 science.288.5470.1418 ref TFIIH consists of ten subunits, 7 of which XPD, XPB, p62, p52, p44, p34 and TTDA form the core complex. The cyclin activating kinase subcomplex CDK7, MAT1, and cyclin H ... links MeshName TranscriptionFactor TFIIH Transcription factors g2 Category Gene expression Category Transcription factors biochem stub cs TFIIH de Transkriptionsfaktor IIH sv TFIIH ... title Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue pages ... XPD and ERCC3 XPB , have helicase and ATPase activities and help create the transcription bubble . In a test tube these subunits are only required for transcription if the DNA template is not already ... domain and possibly other proteins involved in the cell cycle . Next to a vital function in transcription ... more details
protein Name GTF2F1 general transcriptionfactor IIF, polypeptide 1, 74kDa caption image width HGNCid 4652 Symbol GTF2F1 AltSymbols TFIIF, BTF4, RAP74 EntrezGene 2962 OMIM 189968 RefSeq NM 002096 UniProt P35269 PDB ECnumber Chromosome 19 Arm p Band 13.3 LocusSupplementaryData protein Name GTF2F2 general transcriptionfactor IIF, polypeptide 2, 30kDa caption image width HGNCid 4653 Symbol GTF2F2 AltSymbols TFIIF, BTF4, RAP30 EntrezGene 2963 OMIM 189969 RefSeq NM 004128 UniProt P13984 PDB ECnumber Chromosome 13 Arm q Band 14 LocusSupplementaryData protein Name general transcriptionfactor IIF, polypeptide 2 like caption image width HGNCid 4654 Symbol GTF2F2L AltSymbols TFIIF EntrezGene 2964 OMIM RefSeq NG 003013 UniProt PDB ECnumber Chromosome 4 Arm q Band 31.22 LocusSupplementaryData Transcriptionfactor IIF TF sub II sub F is one of several general transcriptionfactor s that make up the RNA polymerase II preinitiation complex . ref name isbn0 13 144946 X cite book author Lewin, Benjamin title Genes VIII publisher Pearson Prentice Hall location Upper Saddle River, NJ year 2004 pages p636 637 isbn 0 13 144946 X oclc doi ref ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue pages ... of DNA in the RNA polymerase II transcription preinitiation complex journal Proc Natl Acad Sci USA volume 94 issue 23 page 12268 73 pmid 9356438 ref TranscriptionFactor IIF is encoded by the gene ..., a general initiation factor for transcription by RNA polymerase II journal Nature volume 355 issue ... TranscriptionFactor TFIIF Cell signaling Transcription factors g2 DEFAULTSORT TranscriptionFactor Ii F Category Molecular genetics Category Proteins Category Gene expression Category Transcription factors ... for RNA polymerase II transcription are dispersed in the human genome journal Hum. Mol. Genet ... title Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens ... more details
protein Name general transcriptionfactor IIE, polypeptide 1, alpha 56kDa caption image width HGNCid 4650 Symbol GTF2E1 AltSymbols TF2E1 EntrezGene 2960 OMIM 189962 RefSeq NM 005513 UniProt P29083 PDB ECnumber Chromosome 3 Arm q Band 21 LocusSupplementaryData q24 protein Name general transcriptionfactor IIE, polypeptide 2, beta 34kDa caption image width HGNCid 4651 Symbol GTF2E2 AltSymbols TF2E2 EntrezGene 2961 OMIM 189964 RefSeq NM 002095 UniProt P29084 PDB ECnumber Chromosome 8 Arm p Band 12 LocusSupplementaryData Transcriptionfactor II E TF sub II sub E is one of several general transcriptionfactor s that make up the RNA polymerase II preinitiation complex . ref name isbn0 13 144946 X cite book author Lewin, Benjamin title Genes VIII publisher Pearson Prentice Hall location Upper Saddle River, NJ year 2004 pages p636 637 isbn 0 13 144946 X oclc doi ref TranscriptionFactor II E is encoded by the GTF2E1 and GTF2E2 genes. ref name pmid1454543 cite journal author Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M title Identification of two large subdomains in TFIIE alpha on the basis of homology between Xenopus and human sequences journal Nucleic Acids Res. volume 20 issue 21 pages 5838 year 1992 pmid 1454543 pmc 334425 doi 10.1093 nar 20.21.5838 issn ref ref name pmid8162052 cite journal author Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC title Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome journal Hum. Mol. Genet ... RG title Conserved sequence motifs in the small subunit of human general transcriptionfactor TFIIE ... transcriptionfactor TFIIE journal Nature volume 354 issue 6352 pages 398 401 year 1991 month ... TranscriptionFactor TFIIE Cell signaling Transcription factors g2 DEFAULTSORT TranscriptionFactor Ii E Category Molecular genetics Category Proteins Category Gene expression Category Transcription .... ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein ... more details
PBB geneid 6667 Sp1 , also known as Specificity Protein 1, is a human transcriptionfactor involved in gene expression in the early development of an organism. It belongs to the Sp KLF family of transcription .... ref See http www.expasy.org uniprot P08047 UniProtKB entry ref The SP1 transcriptionfactor contains a zinc finger zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription .... doi 10.1128 MCB.23.6.1843 1855.2003 ref Interactions Sp1 transcriptionfactor has been shown to Protein ... title Interaction of Sp1 with the growth and cell cycle regulated transcriptionfactor E2F journal Mol ... month July title A set of proteins interacting with transcriptionfactor Sp1 identified in a two hybrid ... of artificialtranscription factors journal J Biol Chem volume 276 issue 31 pages 29466 78 year ... Tat protein and cellular transcriptionfactor Sp1. journal J. Virol. volume 66 issue 6 pages 3932 6 ... The Sp1 transcriptionfactor gene SP1 and the 1,25 dihydroxyvitamin D3 receptor gene VDR are colocalized ... activation by the glutamine rich domains of human transcriptionfactor Sp1. journal Cell volume ... encoding transcriptionfactor Sp1 and functional analysis of the DNA binding domain. journal ... 1 with cellular transcriptionfactor Sp1 and trans activation of viral long terminal repeat. journal ... platelet derived growth factor D transcription requires specific Ser Thr residues in the second ... Factor FactorBook SP1 Transcription factors g2 The PBB Controls template provides controls ... enhancer factor 2C and Sp1 journal J. Biol. Chem. volume 273 issue 40 pages 26218 24 publisher ... 1999 month November title Transcription factors of the Sp1 family interaction with E2F and regulation ... coauthors Forsberg M, Lillhager P, Westin G year 1996 month June title The transcription factors ... laydate quote doi 10.1023 A 1007177623283 ref Host cell factor C1 , ref name pmid10976766 ref name ... proliferation factor HCF 1 journal Genes Dev. volume 17 issue 7 pages 896 911 publisher location ... more details
protein Name GTF2A1 general transcriptionfactor IIA, 1, 19 37kDa caption image width HGNCid 4646 Symbol GTF2A1 AltSymbols EntrezGene 2957 OMIM 600520 RefSeq NM 201595 UniProt P52655 PDB ECnumber Chromosome 14 Arm q Band 31 LocusSupplementaryData protein Name general transcriptionfactor IIA, 2, 12kDa caption image width HGNCid 4647 Symbol GTF2A2 AltSymbols EntrezGene 2958 OMIM 600519 RefSeq NM 004492 UniProt P52657 PDB ECnumber Chromosome 15 Arm q Band 21.3 LocusSupplementaryData Transcriptionfactor TFIIA is a cell nucleus nuclear protein involved in the RNA polymerase II dependent transcription genetics transcription of DNA . ref name pmid17560669 cite journal author H iby T, Zhou H, Mitsiou DJ, Stunnenberg HG title A facelift for the general transcriptionfactor TFIIA journal Biochim. Biophys. Acta volume 1769 issue 7 8 pages 429 36 year 2007 pmid 17560669 doi 10.1016 j.bbaexp.2007.04.008 ref TFIIA is one of several general basal transcriptionfactor s General transcriptionfactor GTF s that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID , a complex composed of the TATA binding protein TBP and TBP associated factors TAFs , as well as the factors TFIIB , TFIIE , TFIIF , and TFIIH . Together, these factors are responsible for promoter biology promoter recognition and the formation of a transcription preinitiation complex PIC capable ... s. References Reflist External links MeshName TranscriptionFactor TFIIA Transcription factors g2 Category Gene expression Category Transcription factors de Transkriptionsfaktor IIA ... in eukaryotic transcription initiation structure of the preinitiation complex journal Proc. Natl. Acad ... that might otherwise bind to TBP and interfere with PIC formation. TFIIA also acts as a transcription ... to increase, or activate, transcription. The requirement for TFIIA in vitro transcription ... transcription journal Genes Dev. volume 8 issue 19 pages 2324 35 year 1994 pmid 7958899 doi 10.1101 ... more details
PBB geneid 2959 Transcriptionfactor IIB TF sub II sub B is one of several general transcriptionfactor ... the general transcription initiation factor IIB journal Nature volume 352 issue 6337 pages 689 ... polymerase II transcription are dispersed in the human genome journal Hum. Mol. Genet. volume 3 issue 1 pages 61 4 year 1994 pmid 8162052 doi 10.1093 hmg 3.1.61 issn ref Transcriptionfactor IIB localizes to the nucleus where it forms a complex the DAB complex with transcription factors TranscriptionFactor II D IID and TFIIA IIA . The protein serves as a bridge between transcriptionfactor IID , which ... web title Entrez Gene GTF2B general transcriptionfactor IIB url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2959 accessdate ref It is involved in the selection of the transcription start site mutations in TFIIB cause a shift in the transcription start site. ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein coding ... annurev.genet.34.1.77 ref Interactions Transcriptionfactor IIB makes protein protein interaction s with the TATA binding protein TBP subunit of transcriptionfactor IID , ref cite journal author Tang ... RPB1 subunit of RNA polymerase II . ref name bushnell ref TranscriptionFactor IIB makes ... sequence specific DNA binding by transcriptionfactor IIB pmid 9420329 doi 10.1101 gad.12.1.34 pmc ... H, et al. title Sequence of general transcriptionfactor TFIIB and relationships to other initiation ... al. title Identification of human autoantibodies to transcriptionfactor IIB. journal Nucleic Acids ... terminal transactivation domain of p65 NF kappa B with TATA binding protein, transcriptionfactor ... type 1 Tat transactivator and the general transcriptionfactor TFIIB with the cellular protein TAP ... Gallery geneid 2959 External links MeshName TranscriptionFactor TFIIB FactorBook GTF2B Cell signaling ... box yes update summary no update citations no DEFAULTSORT TranscriptionFactor Ii B Category Molecular ... more details
PBB geneid 6670 Sp3 transcriptionfactor , also known as SP3 , refers to both a protein and the gene it is encoded by. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC and GT box regulatory elements in target genes. This protein contains a zinc finger DNA binding domain and several transactivation domains, and has been reported to function as a bifunctional transcriptionfactor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoform s have been described for this gene, and one has been reported to initiate translation from a non AUG AUA start codon . Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. ref cite web title Entrez Gene SP3 Sp3 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6670 accessdate ref Interactions Sp3 transcriptionfactor has been shown to Protein protein interaction interact with Histone deacetylase 2 , ref name pmid12151407 cite journal last Won first Jaejoon authorlink coauthors Yim Jeongbin, Kim Tae Kook date October 2002 title Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase hTERT promoter in normal human somatic cells journal J. Biol. Chem. volume 277 issue 41 pages 38230 8 publisher location United States issn 0021 9258 ... Frauke, Suske Guntram date October 2002 title Transcriptionfactor Sp3 is silenced through SUMO ... update summary no update citations yes DEFAULTSORT Sp3 TranscriptionFactor Category Transcription ... first H authorlink coauthors Geymayer S, Haidweger E date November 1999 title Transcription ... of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone ... year 2003 pmid 12943729 doi 10.1016 S0960 0760 03 00230 9 refend PDB Gallery geneid 6670 Transcription ... more details
PBB geneid 6671 Transcriptionfactor Sp4 is a protein that in humans is encoded by the SP4 gene . ref name pmid1454515 cite journal author Hagen G, Muller S, Beato M, Suske G title Cloning by recognition site screening of two novel GT box binding proteins a family of Sp1 related genes journal Nucleic Acids Res volume 20 issue 21 pages 5519 25 year 1993 month Jan pmid 1454515 pmc 334381 doi 10.1093 nar 20.21.5519 ref ref name entrez cite web title Entrez Gene SP4 Sp4 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6671 accessdate ref The PBB ... updates. PBB Summary section title summary text Interactions Sp4 transcriptionfactor has been shown ... author Hagen G, Dennig J, Preiss A, et al. title Functional analyses of the transcriptionfactor ..., Grzeschik KH, Suske G title Human Sp4 transcriptionfactor gene SP4 maps to chromosome 7p15. journal ... title POZ domain transcriptionfactor, FBI 1, represses transcription of ADH5 FDH by interacting with the zinc ... Association of the Asn306Ser variant of the SP4 transcriptionfactor and an intronic variant in the beta ... year 2007 pmid 17356515 doi refend PDB Gallery geneid 6671 External links MeshName Sp4 TranscriptionFactorTranscription factors g2 The PBB Controls template provides controls for Protein Box Bot, please ... last Rotheneder first H authorlink coauthors Geymayer S, Haidweger E year 1999 month Nov. title Transcription ... citations cite journal author Suske G title The Sp family of transcription factors. journal Gene volume ... 523756 cite journal author Rotheneder H, Geymayer S, Haidweger E title Transcription factors of the Sp1 ... mediate transcription of rod specific cGMP phosphodiesterase beta subunit gene involvement of multiple ... by the early growth response 1 EGR 1 and Sp family transcription factors. journal Nucleic Acids Res ... growth factor receptor 2 expression is induced by 17beta estradiol in ZR 75 breast cancer cells by estrogen ... no update protein box yes update summary yes update citations yes Category Transcription factors gene ... more details
PBB geneid 4286 Microphthalmia associated transcriptionfactor MITF is a basic helix loop helix leucine zipper transcriptionfactor involved in melanocyte ref name pmid16899407 cite journal author Levy ... DE title MITF and TFE3 members of a b HLH ZIP transcriptionfactor family essential for osteoclast ... genes confirmed by at least two independent sources of this transcriptionfactor include, CENTER TABLE ... author Luchin A, Purdom G, Murphy K, et al. title The microphthalmia transcriptionfactor reulates ... The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcriptionfactor ... author Yasumoto K, Takeda K, Saito H, et al. title Microphthalmia associated transcriptionfactor ..., Akasaka E, et al. title Epistatic connections between microphthalmia associated transcriptionfactor ... A, Du J, Angeletti B, et al. title The microphthalmia transcriptionfactor MITF controls expression ... E, et al. title Microphthalmia associated transcriptionfactor regulates RAB27A gene expression and controls ... transcriptionfactor in melanocytes journal J. Biol. Chem. volume 275 issue 29 pages 21920 7 ... by inhibition of the activity of melanocyte transcriptionfactor, MITF journal Nucleic Acids Res. volume ... Mar. title Interaction and cooperation of mi transcriptionfactor MITF and myc associated zinc finger protein related factor MAZR for transcription of mouse mast cell protease 6 gene journal J. Biol ... a repressor of microphthalmia transcriptionfactor journal J. Biol. Chem. volume 277 issue 3 pages ... 2002 month Feb. title The microphthalmia transcriptionfactor and the related helix loop helix zipper ... associated transcriptionfactor MITF protein levels by association with the ubiquitin conjugating enzyme ... associated transcriptionfactor interacts with LEF 1, a mediator of Wnt signaling journal EMBO J. volume ... transcriptionfactorTranscription factors g1 The PBB Controls template provides controls for Protein ... Associated TranscriptionFactor Category Transcription factors Category Gene expression ... more details
PBB geneid 221833 Transcriptionfactor Sp8 also known as specificity protein 8 SP 8 or Btd transcriptionfactor buttonhead ref name pmid14597661 cite journal author Treichel D, Sch ck F, J ckle H, Gruss P, Mansouri A title mBtd is required to maintain signaling during murine limb development journal Genes Dev. volume 17 issue 21 pages 2630 5 year 2003 month November pmid 14597661 pmc 280612 doi 10.1101 gad.274103 url ref is a protein that in humans is encoded by the SP8 gene . ref name pmid14526104 cite journal author Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ title Sp8 is crucial for limb outgrowth and neuropore closure journal Proc. Natl. Acad. Sci. U.S.A. volume 100 issue 21 pages 12195 200 year 2003 month October pmid 14526104 pmc 218735 doi 10.1073 pnas.2134310100 url ref ref name entrez cite web title Entrez Gene Sp8 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 221833 accessdate ref Sp8 is a transcriptionfactor in the Sp KLF family . Function Sp8 mediates limb outgrowth during early development. ref name pmid14597661 Sp8 deletion in mice resulted in severe exencephaly . ref name pmid16476661 cite journal author Waclaw RR, Allen ZJ, Bell SM, Erd lyi F, Szab G, Potter SS, Campbell K title The zinc finger transcriptionfactor Sp8 regulates the generation and diversity of olfactory bulb interneurons journal Neuron volume 49 issue 4 pages 503 16 year 2006 month February pmid 16476661 doi 10.1016 j.neuron.2006.01.018 ref References reflist Further reading refbegin 2 cite journal author Lee MT, Chen CH, Lee CS, et al. title Genome wide association study of bipolar I disorder in the Han Chinese population. journal Mol. Psychiatry volume 16 issue 5 pages 548 56 year 2011 pmid 20386566 doi 10.1038 mp.2010.43 cite journal author Milona MA, Gough JE, Edgar AJ title Genomic structure and cloning ... refend gene 7 stub Transcription factors g2 Category Transcription factors ... more details
Infobox protein family Symbol DP Name DP image PDB 2aze EBI.jpg width caption structure of the rb c terminal domain bound to an e2f1 dp1 heterodimer Pfam PF08781 Pfam clan InterPro IPR014889 SMART PROSITE PDOC00359 MEROPS S9 SCOP 1c5e TCDB OPM family OPM protein CAZy GT1 CDD In molecular biology, transcription factor DP is a family of proteins which function as transcription factors . DP forms a heterodimer with E2F and Transcriptional regulation regulate s genes involved in cell cycle progression. The Transcription genetics transcriptional activity of E2F is inhibited by the retinoblastoma protein which Molecular binding bind s to the E2F DP heterodimer ref name pmid16360038 cite journal author Rubin SM, Gall AL, Zheng N, Pavletich NP title Structure of the Rb C terminal domain bound to E2F1 DP1 a mechanism for phosphorylation induced E2F release journal Cell volume 123 issue 6 pages 1093 106 year 2005 month December pmid 16360038 doi 10.1016 j.cell.2005.09.044 url ref and negatively Regulation of gene expression regulates the G1 S Transition genetics transition . See also E2F TFDP1 TFDP2 References reflist InterPro content IPR014889 Category Protein domains ... more details
PBB geneid 5978 RE1 Silencing Transcriptionfactor REST , also known as Neuron Restrictive Silencer Factor ... Entrez Gene REST RE1 silencing transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db ... finger transcriptionfactor family. It represses transcription by binding a DNA sequence element ... cite web title Entrez Gene REST RE1 silencing transcriptionfactor url http www.ncbi.nlm.nih.gov sites ..., Lietz M, Cramer M title Biological activity and modular structure of RE 1 silencing transcriptionfactor ... Neuron specific splicing of zinc finger transcriptionfactor REST NRSF XBR is frequent in neuroblastomas ... cite journal author Lietz M, Hohl M, Thiel G title RE 1 silencing transcriptionfactor REST regulates human synaptophysin gene transcription through an intronic sequence specific DNA binding site. journal ... by the neuron restrictive silencer factor repressor element 1 silencing transcriptionfactor. journal ... CJ, Anderson DJ title The neuron restrictive silencer factor NRSF a coordinate repressor of multiple ... remodeling occurs, causing the gene to be turned off . Interactions RE1 silencing transcriptionfactor has been shown to Protein protein interaction interact with RCOR1 . ref name pmid10449787 cite ... CJ, Anderson DJ title The neuron restrictive silencer factor NRSF a coordinate repressor of multiple ... A zinc finger protein that represses transcription of the human MHC class II gene, DPA. journal ... T, Kojima T, Mori N title Neural restrictive silencer factor recruits mSin3 and histone deacetylase ... PJ, Quinn JP title A splice variant of the neuron restrictive silencer factor repressor is expressed ... author Kojima T, Murai K, Naruse Y, et al. title Cell type non selective transcription of mouse and human genes encoding neural restrictive silencer factor. journal Brain Res. Mol. Brain Res. volume ... by neuron restrictive silencer factor journal J. Biol. Chem. volume 278 issue 37 pages 35057 62 year ... al. title Huntingtin interacts with REST NRSF to modulate the transcription of NRSE controlled ... more details
SPI1 PU.1 , SPIB , Spi C transcriptionfactor SPIC TCF ELK1 , ELK4 SAP1 , ELK3 NET SAP2 LIN TEL ETV6 ..., such as through gene fusion . For example, the ERG ETS transcriptionfactor is fused to the EWS gene ... MA, Chinnaiyan AM title Recurrent fusion of TMPRSS2 and ETS transcriptionfactor genes in prostate ... doi 10.1002 bies.10068 refend Transcription factors g3 DEFAULTSORT Ets TranscriptionFactor Family Category Gene expression Category Transcription factors id ETS ... of molecular biology , the ETS E twenty six family is one of the largest families of transcription ... Hartman A, Duval DL, Bradford AP title ETS transcription factors in endocrine systems journal Trends ... factor ERF PE2 , ets variant 3 ETV3 PE1 ESE ELF3 ESE1 ESX , ELF5 ESE2 , EHF gene ESE3 EHF ETS ... When Ets transcription factors meet their partners journal Bioessays volume 24 issue 4 pages 362 ... , transcriptional activators , or both. ref cite journal author Sharrocks AD title The ETS domain transcriptionfactor family journal Nat Rev Mol Cell Biol volume 2 issue 11 pages 827 37 year 2001 pmid ... studies of ETS transcription factors journal Crit Rev Oncog volume 11 issue 3 4 pages 227 53 ... of transcription factors journal Gene volume 303 pages 11 34 year 2003 pmid 12559563 doi 10.1016 ... sj.onc.1204034 cite journal author Verger A, Duterque Coquillaud M title When Ets transcription ... more details
PBB geneid 121340 Transcriptionfactor Sp7 is a protein that in humans is encoded by the SP7 gene . ref name pmid11792318 cite journal author Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B title The novel zinc finger containing transcriptionfactor osterix is required for osteoblast differentiation and bone formation journal Cell volume 108 issue 1 pages 17 29 year 2002 month Jan pmid 11792318 pmc doi 10.1016 S0092 8674 01 00622 5 ref ref name entrez The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text SP7 is a C2H2 type zinc finger transcriptionfactor of the SP gene family and a putative master regulator of bone cell differentiation Gao et al., 2004 . supplied by OMIM ref name entrez cite web title Entrez Gene SP7 Sp7 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 121340 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Gronthos S, Chen S, Wang CY, et al. title Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. journal J. Bone Miner. Res. volume 18 issue 4 pages ... year 2007 pmid 17352693 doi 10.1042 BJ20070104 refend External links MeshName Sp12 TranscriptionFactorTranscription factors g2 The PBB Controls template provides controls for Protein Box Bot, please ... 9 cite journal author Amorim BR, Okamura H, Yoshida K, et al. title The transcriptional factor Osterix ... protein box yes update summary yes update citations yes Category Transcription factors gene 12 ... more details
PBB geneid 6668 Transcriptionfactor Sp2 is a protein that in humans is encoded by the SP2 gene . ref name pmid1341900 cite journal author Kingsley C, Winoto A title Cloning of GT box binding proteins a novel Sp1 multigene family regulating T cell receptor gene expression journal Mol Cell Biol volume 12 issue 10 pages 4251 61 year 1992 month Oct pmid 1341900 pmc 360348 doi ref ref name pmid9730617 cite journal author Scohy S, Van Vooren P, Szpirer C, Szpirer J title Assignment1 of Sp genes to rat chromosome bands 7q36 Sp1 , 10q31 q32.1 Sp2 , 3q24 q31 Sp3 and 6q33 Sp4 and of the SP2 gene to human chromosome bands 17q21.3 q22 by in situ hybridization journal Cytogenet Cell Genet volume 81 issue 3 4 pages 273 4 year 1998 month Oct pmid 9730617 pmc doi 10.1159 000015044 ref ref name entrez cite web title Entrez Gene SP2 Sp2 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6668 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the Sp subfamily of Sp XKLF transcription factors. Sp family proteins are sequence specific DNA binding proteins characterized by an amino terminal trans activation ... Interactions Sp2 transcriptionfactor has been shown to Protein protein interaction interact with E2F1 ... 13 year 2007 pmid 17071613 doi 10.1074 jbc.M607720200 refend External links MeshName Sp2 TranscriptionFactor FactorBook SP2 Transcription factors g2 The PBB Controls template provides controls for Protein ... S, Haidweger E year 1999 month Nov. title Transcription factors of the Sp1 family interaction ... G title A tale of three fingers the family of mammalian Sp XKLF transcription factors. journal ... E title Transcription factors of the Sp1 family interaction with E2F and regulation of the murine ... manual inspection no update protein box yes update summary yes update citations yes Category Transcription ... more details
. PBB geneid 1386 Activating transcriptionfactor 2 , also known as ATF2 , is a protein that, in humans ... transcriptionfactor 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1386 accessdate ref Function This gene encodes a transcriptionfactor that is a member of the leucine ... title Transcriptionfactor ATF2 regulation by the JNK signal transduction pathway journal Science ... title Phosphorylation of Activation TranscriptionFactor 2 at Serine 121 by Protein Kinase C Controls c Jun mediated Activation of Transcription journal J. Biol. Chem. volume 284 issue 13 pages 8567 ... S, van Dam H, Zoumpourlis V title Overexpression of activating transcriptionfactor 2 is required ... j.molcel.2005.04.015 url issn ref Interactions Activating transcriptionfactor 2 has been shown ... Y, Obata Y, Yokoyama KK title Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcriptionfactor 2, in Escherichia coli by Jun N terminal ..., a regulator of activating transcriptionfactor 2 response to stress and DNA damage journal Mol ... R, Feuerstein N title Association of activating transcriptionfactor 2 ATF2 with the ubiquitin ... doi 10.1074 jbc.273.10.5892 url issn ref See also Activating transcriptionfactor References Reflist ... expression of the human TGF beta 2 gene through transcriptionfactor ATF 2. journal Nature volume ... response element binding protein and activating transcriptionfactor 2 by protein protein interactions ... Activating TranscriptionFactor 2 Category Transcription factors Category Moonlighting proteins ... with c Jun and stimulates CRE dependent transcription. The protein is also a histone acetyltransferase ... specific factors that activate transcription by direct effects on chromatin components. Additional ... cite journal author Hai T, Curran T title Cross family dimerization of transcription factors ... Casein kinase II interacts with the bZIP domains of several transcription factors journal Nucleic ... more details
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