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Encyclopedia results for Aryl hydrocarbon receptor nuclear translocator

Aryl hydrocarbon receptor nuclear translocator





Encyclopedia results for Aryl hydrocarbon receptor nuclear translocator

  1. Aryl hydrocarbon receptor nuclear translocator

    PBB geneid 405 The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand bound aryl hydrocarbon receptor AhR , and is required for receptor function ... Aryl hydrocarbon receptor nuclear translocator has been shown to Protein protein interaction interact ... coactivators by the aryl hydrocarbon receptor aryl hydrocarbon receptor nuclear translocator complex ... of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor ... Y, Kuo MT title Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two hybrid system. journal Biochem. Pharmacol. volume ... aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins direct ... minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein ... pmc 232345 Refend PDB Gallery geneid 405 External links MeshName Aryl Hydrocarbon Receptor Nuclear Translocator ... of the Drosophila single minded protein that interact with the mouse aryl hydrocarbon receptor nuclear .... The ligand free, cytosolic form of the aryl hydrocarbon receptor is complexed to Hsp90 heat shock ... interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo journal J. Biol ... laysource laydate quote ref Aryl hydrocarbon receptor , ref name pmid7628454 cite journal last Lindebro ... O title Identification of the Ah receptor nuclear translocator protein Arnt as a component of the DNA ... receptor nuclear translocator protein ARNT . journal Mol. Cell. Biol. volume 14 issue 9 pages 6075 ... journal author Johnson B, Brooks BA, Heinzmann C, et al. title The Ah receptor nuclear translocator ... sites of the Ah receptor and Ah receptor nuclear translocator. journal J. Biol. Chem. volume ... spliced variants encoding different isoforms have been described for this gene. The aryl hydrocarbon ... ref and Nuclear receptor coactivator 2 . ref name pmid12024042 References Reflist Further reading Refbegin ...   more details



  1. Aryl hydrocarbon receptor repressor

    protein Name aryl hydrocarbon receptor repressor caption image width HGNCid 346 Symbol AHRR AltSymbols AHH, AHHR EntrezGene 57491 OMIM 606517 RefSeq NM 020731 UniProt Q9ULI6 PDB ECnumber Chromosome 5 Arm p Band 15.33 LocusSupplementaryData The aryl hydrocarbon receptor repressor also known as AHRR is a human gene . ref name pmid11423533 cite journal author Baba T, Mimura J, Gradin K, Kuroiwa A, Watanabe T, Matsuda Y, Inazawa J, Sogawa K, Fujii Kuriyama Y title Structure and expression of the Ah receptor repressor gene journal J. Biol. Chem. volume 276 issue 35 pages 33101 10 year 2001 month August pmid 11423533 doi 10.1074 jbc.M011497200 url ref Function Dioxin chemical Dioxin is a Teratogenesis teratogen that exerts its effects through the aryl hydrocarbon receptor AhR in conjunction with the Receptor biochemistry receptor s binding partner, aryl hydrocarbon receptor nuclear translocator ..., Birrer M, Cuttitta F title The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene ... expression of aryl hydrocarbon receptor repressor gene in human tissues organ specific distribution ... author Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y title The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor AhRR on the Growth of Human Breast Cancer MCF 7 Cells journal Biol. Pharm. Bull ... for binding to the arylhydrocarbon receptor. ref name pmid18000031 cite journal author Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME title Repression of aryl hydrocarbon receptor AHR signaling by AHR repressor role of DNA binding and competition for AHR nuclear translocator journal Mol. Pharmacol. volume 73 issue 2 pages 387 98 year 2008 month February pmid 18000031 doi 10.1124 mol.107.040204 url ref Expression of the repressor is stimulated by the receptor translocator protein dimer heterodimer , thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa B . The AhRR ...   more details



  1. Nuclear receptor

    magenta and two molecules of the Nuclear receptor coactivator 2 NCOA2 coactivator red . The PPAR ... that affects the receptor s behavior is present. More specifically, ligand binding to a nuclear ... . As discussed below, nuclear receptors may be classified according to either Nuclear receptor Mechanism of action mechanism ref name Mangelsdorf 1995 ref name Novac 2004 or Nuclear receptor Family ... Structures of selected endogenous nuclear receptor ligands and the name of the receptor that each ... in sequence between various nuclear receptors. valign top Image Nuclear Receptor Structure.png thumb ... sequence of a nuclear receptor. br Bottom 3D structures of the DBD bound to DNA and LBD bound to hormone regions of the nuclear receptor. The structures shown are of the estrogen receptor . Experimental ... hydroxycholesterol space filling model carbon white, oxygen red and the Nuclear receptor coactivator ... PROSITE SCOP 1lbd TCDB OPM family OPM protein CDD cd06157 Mechanism of action Image Nuclear receptor action.png thumb 475px Mechanism nuclear receptor action . This figure depicts the mechanism of a class I nuclear receptor NR that, in the absence of ligand biochemistry ligand , is located in the cytosol ... sequence of DNA known as a hormone response element hormone response element HRE . The nuclear receptor ..., which results in a change in cell function. Image Type ii nuclear receptor action.png thumb 475px Mechanism nuclear receptor action . This figure depicts the mechanism of a class II nuclear receptor ... of illustration, the nuclear receptor shown here is the thyroid hormone receptor thyroid hormone ... receptor . ref name AutoJQ 1 It has been noted that some of the NR subfamily 2 nuclear receptors ... to a single half site HRE. As of now, these nuclear receptors are considered orphan receptor s, as their endogenous ligands still unknown. The nuclear receptor DNA complex chemistry complex then recruits ... binding to the nuclear receptor causes dissociation of corepressor and recruitment of coactivation ...   more details



  1. Nuclear receptor coactivator 2

    laysource laydate quote ref Aryl hydrocarbon receptor nuclear translocator , ref name pmid12024042 cite ... SRC 1 p160 family of transcriptional coactivators by the aryl hydrocarbon receptor aryl hydrocarbon receptor nuclear translocator complex journal Mol. Cell. Biol. volume 22 issue 12 pages 4319 ...PBB geneid 10499 The nuclear receptor coactivator 2 gene NCOA2 is a transcription coregulator transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic ... 232124 ref NCOA2 is also frequently called glucocorticoid receptor interacting protein 1 GRIP1 , steroid receptor coactivator 2 SRC 2 , or transcriptional mediators intermediary factor 2 TIF2 . Interactions Nuclear receptor coactivator 2 has been shown to Protein protein interaction interact with DDX17 ... Shigeaki year 2003 month Jun. title The chromatin remodeling complex WINAC targets a nuclear receptor ... 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha journal ... nuclear receptor coactivator 2 3 nuclear receptor coactivator 2 NURSA C90 Further reading refbegin ... between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. journal Blood ... signal input and output domains of the 160 kilodalton nuclear receptor coactivator proteins. journal ... author Atkins GB, Hu X, Guenther MG, et al. title Coactivators for the orphan nuclear receptor RORalpha ... enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase ... nuclear receptors. NCOA2 in turn acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression. ref name ..., a 160 kDa transcriptional mediator for the ligand dependent activation function AF 2 of nuclear receptors ... S year 2001 month Mar. title A subfamily of RNA binding DEAD box proteins acts as an estrogen receptor ... quote pmc 145523 ref Androgen receptor , ref name pmid14593076 cite journal last Song first Liang ...   more details



  1. Aryl

    about the aryl organic functional group the fleshy covering of certain seeds aril In the context of organic molecules, aryl refers to any functional group or substituent derived from an aromatic ring , be it phenyl , naphthyl , thiophene thienyl , indole indolyl , etc. see IUPAC nomenclature . ref http goldbook.iupac.org A00464.html ref Aryl is used for the sake of abbreviation or generalization, and Ar is used as a placeholder for the aryl group in chemical structure diagrams. A simple aryl group is phenyl , C sub 6 sub H sub 5 sub it is derived from benzene . The tolyl group, CH sub 3 sub C sub 6 sub H sub 4 sub , is derived from toluene methylbenzene . The xylyl group, CH sub 3 sub sub 2 sub C sub 6 sub H sub 3 sub , is derived from xylene dimethylbenzene , while the naphthyl group, C sub 10 sub H sub 7 sub , is derived from naphthalene . Arylation is simply any chemical process in which an aryl group is attached to a substrate. See also Alkyl Aryl hydrocarbon receptor , a bodily target for Dioxins and dioxin like compounds dioxin s ref name pmid16545780 cite journal author Bock KW, K hle C title Ah receptor dioxin mediated toxic responses as hints to deregulated physiologic functions journal Biochem. Pharmacol. volume 72 issue 4 pages 393 404 year 2006 pmid 16545780 doi 10.1016 j.bcp.2006.01.017 ref Arene compound References Reflist Category Aryl groups Category Substituents aromatic stub ar be be x old ca Grup aril cs Aryl de Arylgruppe et Ar lr hm es Grupo arilo fa fr Aryle it Arile hu Arilcsoport mk nl Arylgroep ja pl Grupa arylowa pt Arila ru sv Arylgrupp uk zh ...   more details



  1. Nuclear Receptor Signaling Atlas

    The Nuclear Receptor Signaling Atlas NURSA is a United States National Institutes of Health funded research consortium focussed on nuclear receptors and transcription coregulator nuclear receptor coregulators . ref name pmid16051673 cite journal author Margolis RN, Evans RM, O Malley BW title The Nuclear Receptor Signaling Atlas development of a functional atlas of nuclear receptors journal Mol. Endocrinol. volume 19 issue 10 pages 2433 6 year 2005 month October pmid 16051673 doi 10.1210 me.2004 0461 url ref ref name pmid16381851 cite journal author Lanz RB, Jericevic Z, Zuercher WJ, Watkins C, Steffen DL, Margolis R, McKenna NJ title Nuclear Receptor Signaling Atlas hyperlinking the nuclear receptor signaling community journal Nucleic Acids Res. volume 34 issue Database issue pages D221 6 year 2006 month January pmid 16381851 pmc 1347392 doi 10.1093 nar gkj029 url ref Its co principal investigators are Bert W. O Malley Bert O Malley of Baylor College of Medicine and Ronald M. Evans Ron Evans of the Salk Institute. References Reflist External links cite web url http www.nursa.org title NURSA Nuclear Receptor Signaling Atlas author authorlink coauthors date format work publisher pages language archiveurl archivedate quote Receptors, Coactivators, Corepressors and Ligands accessdate 2008 08 27 Category Bioinformatics Category Biological databases bioinformatics stub ...   more details



  1. Nuclear receptor coregulators

    Nuclear receptor coregulators ref name Copyright This article is based on the transcript of an animated course on the Nuclear Receptor Signaling Atlas NURSA website entitled Nuclear receptor signaling ..., the Nuclear Receptor Signaling Atlas, on August 25th 2008. ref are a class of transcription coregulators ... receptor superfamily. A comprehensive database of nuclear receptor coregulators can be found at the http www.nursa.org Nuclear Receptor Signaling Atlas website . Introduction The ability of nuclear ... receptor coactivator was steroid receptor coactivator 1, or nuclear receptor coactivator 1 SRC 1 , first ... 7481822 doi 10.1126 science.270.5240.1354 issue 5240 ref SRC 1 and two related proteins, nuclear receptor ... pnas.93.10.4948 issue 10 pmc 39385 ref and nuclear receptor coactivator 3 ACTR p CIP , initially ... D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. title Nuclear receptor coactivator ACTR ... co activator p CIP binds CBP and mediates nuclear receptor function journal Nature volume 387 ... amino acids where L leucine and X any amino acid , or nuclear receptor box, present from a single ... on a critical conformation of the receptor AF 2 domain, as well as upon nuclear receptor box like ... isolated in rapid succession, nuclear receptor corepressor, or nuclear receptor co repressor 1 NCoR ... by a nuclear receptor co repressor journal Nature volume 377 pages 397 404 year 1995 pmid 7566114 ... to the coactivator nuclear receptor boxes. ref name Hu 1994 cite journal author Hu, X., and Lazar ..., M. Geoffrey Rosenfeld Rosenfeld MG title Combinatorial roles of the nuclear receptor corepressor in transcription .... title Distinct steady state nuclear hormone receptor coregulator complexes exist in vivo journal Proc ... aspects of nuclear receptor and coregulator action remain poorly defined, a broad composite model of nuclear receptor action invokes corepressors as critical mediators of nuclear receptor silencing ... of nuclear receptor coregulators in a variety of molecular functions within the cell, it should come ...   more details



  1. Nuclear receptor coactivator 3

    PBB geneid 8202 The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded ... several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA3, in turn ... nuclear receptor s in the upregulation of gene expression. ref name Anzick 1997 cite journal author ... Nuclear receptor coactivator 3 has been shown to Protein protein interaction interact with DDX17 ... expression of nuclear receptor coactivators in the mouse lung journal Am. J. Physiol. Lung Cell ... mechanisms of nuclear receptor regulation by receptor associated coactivator 3 journal J. Biol. Chem ... D, Nash A, Nagy L, Privalsky M L, Nakatani Y, Evans R M year 1997 month Aug. title Nuclear receptor ... ref References Reflist External links MeshName nuclear receptor coactivator 3 3 nuclear receptor coactivator ... L title Molecular structure and biological function of the cancer amplified nuclear receptor coactivator ... first9 Melvin G. cite journal author Li H, Gomes PJ, Chen JD title RAC3, a steroid nuclear receptor ... OP last9 Trent first9 JM cite journal author Chen H title Nuclear receptor coactivator ACTR is a novel ... title Differential mechanisms of nuclear receptor regulation by receptor associated coactivator 3 ... yes Category Transcription coregulators fr Nuclear receptor coactivator 3 ... receptor coactivator amplified in breast and ovarian cancer journal Science volume 277 issue 5328 ..., A novel 160 kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator 1 journal J. Biol. Chem. volume 272 issue 44 pages 27629 34 year 1997 month ... in breast 1 AIB1 , steroid receptor coactivator 3 SRC 3 , or thyroid hormone receptor activator molecule ... JM, Meltzer PS title AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer journal ... WW title TRAM 1, A novel 160 kDa thyroid hormone receptor activator molecule, exhibits distinct properties ...   more details



  1. Nuclear receptor coactivator 1

    PBB geneid 8648 The nuclear receptor coactivator 1 gene NCOA1 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity EC number 2.3.1.48 . NCOA1 is recruited to DNA promotion sites by ligand activated nuclear ... 9575154 ref NCOA1 is also frequently called steroid receptor coactivator 1 SRC 1 . Interactions Nuclear receptor coactivator 1 has been shown to Protein protein interaction interact with Thyroid hormone receptor beta , ref name pmid9751500 cite journal doi 10.1210 en.139.10.4197 last Liu first Y authorlink ... 1998 month Jun. title A regulatory role for RIP140 in nuclear receptor activation journal Mol. Endocrinol ... MeshName nuclear receptor coactivator 1 3 nuclear receptor coactivator 1 NURSA C89 Further reading .... Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. ref name Onate ... of a coactivator for the steroid hormone receptor superfamily journal Science volume 270 issue ... BW title The steroid receptor coactivator 1 contains multiple receptor interacting and activation ... role of steroid receptor coactivator 1 in ligand induced transactivation by thyroid hormone receptor journal Mol. Endocrinol. volume 11 issue 6 pages 755 67 publisher location UNITED STATES issn ... Dec. title Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways ... acts as an estrogen receptor alpha coactivator through the N terminal activation domain AF 1 ... protein and steroid receptor coactivators in vitamin D receptor mediated transcription journal J. Biol ... laydate quote ref Androgen receptor , ref name pmid15256534 cite journal last Masiello first David ... of the androgen receptor by interleukin 6 and the role of steroid receptor coactivator 1 in prostate ... and AF2 domains of the androgen receptor interact with distinct regions of SRC1 journal Mol. Cell ... of the steroid receptor coactivator 1 SRC1 CREB binding protein interaction interface and its importance ...   more details



  1. Hydrocarbon

    chemistry are as follows Saturated hydrocarbons alkane s are the simplest of the hydrocarbon species ... 978 3 54 076885 2 ref Unsaturated hydrocarbon s have one or more double or triple bonds between carbon .... The general formula for a saturated hydrocarbon containing one ring is C sub n sub H sub 2n sub . ref name Silderberg Aromatic hydrocarbon s, also known as arene s, are hydrocarbons that have ... bonding or catenation of carbon preventing entire saturation of the hydrocarbon by the formation ... to as catenation , and allows hydrocarbon to form more complex molecules, such as cyclohexane ,and in rarer ... oil or natural gas . The hydrocarbon is burnt and the heat is used to heat water, which is then circulated ... is required for combustion to take place. The simplest hydrocarbon, methane, burns as follows ... organic chemicals . The extraction of liquid hydrocarbon fuel from sedimentary basin s is integral ... petroleum origin Biohydrocarbon Energy storage Fractional distillation Functional group Hydrocarbon ... ca Hidrocarbur cs Uhlovod ky cy Hydrocarbon da Kulbrinte de Kohlenwasserstoffe et S sivesinikud ... simple Hydrocarbon sk Uh ovod k sl Ogljikovodik sr sh Ugljikovodici su Hidrokarbon ...   more details



  1. Nuclear receptor co-repressor 2

    D, Lee JE, Safe S title Interactions of nuclear receptor coactivator corepressor proteins with the aryl hydrocarbon receptor complex journal Arch. Biochem. Biophys. volume 367 issue 2 pages 250 7 year 1999 pmid 10395741 doi 10.1006 abbi.1999.1282 cite journal author Bailey P title The nuclear receptor ...PBB geneid 9612 The nuclear receptor co repressor 2 gene NCOR2 is a transcription coregulator transcriptional coregulatory protein that contains several nuclear receptor interacting domains. In addition, NCOR2 appears to recruit histone deacetylase s to DNA promoter regions. Hence NCOR2 assists nuclear ... domains as well as two or three C terminus C terminal nuclear receptor interacting domains ... D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM title Nuclear receptor repression mediated by a complex ... in a variant referred to as TRAC 1. ref name Sande 1996 Interactions Nuclear receptor co repressor ... R, Jameson J L year 1998 month Dec. title The interaction of the vitamin D receptor with nuclear receptor ... A novel nuclear receptor corepressor complex, N CoR, contains components of the mammalian SWI SNF complex ... signal cointegrator 2 as transcriptional coregulators of the orphan nuclear receptor Nur77 journal ... Hui, Chen J Don year 2003 month Feb. title Regulation of androgen receptor activity by the nuclear ... repression and nuclear receptor signaling journal PNAS Proc. Natl. Acad. Sci. U.S.A. ... nuclear receptor repression and activation journal Genes Dev. volume 15 issue 9 pages 1140 51 publisher ... by the thyroid hormone receptor mediated by a nuclear receptor co repressor journal Nature volume ... Dejean first4 A last5 Privalsky first5 ML cite journal author Chen H title Nuclear receptor coactivator ... forms of human and mouse nuclear receptor corepressor SMRT journal Proc. Natl. Acad. Sci. U.S.A. volume ... and thyroid hormone receptors extended isoform that is more related to the nuclear receptor corepressor ... links MeshName nuclear receptor corepressor 2 3 nuclear receptor corepressor 2 NURSA C98 PBB Controls ...   more details



  1. Photoreceptor cell-specific nuclear receptor

    PBB geneid 10002 The photoreceptor cell specific nuclear receptor PNR , also known as NR2E3 nuclear receptor subfamily 2, group E, member 3 , is a protein that in humans is encoded by the NR2E3 gene . ref name pmid10220376 cite journal author Kobayashi M, Takezawa S, Hara K, Yu RT, Umesono Y, Agata K, Taniwaki M, Yasuda K, Umesono K title Identification of a photoreceptor cell specific nuclear receptor journal Proc. Natl. Acad. Sci. U.S.A. volume 96 issue 9 pages 4814 9 year 1999 pmid 10220376 doi 10.1073 pnas.96.9.4814 pmc 21774 ref PNR is a member of the nuclear receptor super family of intracellular ... AF, Stone EM, Sheffield VC, Jacobson SG title The nuclear receptor NR2E3 plays a role in human retinal ... J, Ferraz F, Yu Umesono R, Munnich A, Kaplan J title The photoreceptor cell specific nuclear receptor ... author Chen F, Figueroa DJ, Marmorstein AD, et al. title Retina specific nuclear receptor A potential ... AV, et al. title Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome ... author Gerber S, Rozet JM, Takezawa SI, et al. title The photoreceptor cell specific nuclear receptor .... title Photoreceptor specific nuclear receptor NR2E3 functions as a transcriptional activator in rod ... of photoreceptor specific nuclear receptor NR2E3 in rod photoreceptors of fetal human retina journal ... The rod photoreceptor specific nuclear receptor Nr2e3 represses transcription of multiple cone specific ... specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription ... nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa journal Am. J. Hum. Genet. volume ... R, Bennett J, Weleber RG, Fishman GA, Wright AF, Stone EM, Sheffield VC title Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate journal Nat. Genet ... doi 10.1093 hmg 10.16.1619 cite journal author Milam AH, Rose L, Cideciyan AV, et al. title The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration journal ...   more details



  1. Nuclear receptor related 1 protein

    PBB geneid 4929 The Nuclear receptor related 1 protein NURR1 also known as NR4A2 nuclear receptor subfamily 4, group A, member 2 is a protein that in humans is encoded by the NR4A2 gene . ref name pmid7706727 cite journal author Okabe T, Takayanagi R, Imasaki K, Haji M, Nawata H, Watanabe T title cDNA cloning of a NGFI B nur77 related transcription factor from an apoptotic human T cell line journal J. Immunol. volume 154 issue 8 pages 3871 9 year 1995 pmid 7706727 doi issn url http www.jimmunol.org cgi content abstract 154 8 3871 ref NURR1 is a member of the nuclear receptor family of intracellular ... nuclear receptor NURR1 journal Nucleic Acids Res. volume 34 issue 19 pages 5515 27 year 2006 pmid .... ref name entrez cite web title Entrez Gene NR4A2 nuclear receptor subfamily 4, group A, member ... had limited results. Interactions Nuclear receptor related 1 protein has been shown to Protein protein interaction interact with Retinoic acid receptor alpha ref name pmid7705655 cite journal author ... H title Organization of the human orphan nuclear receptor Nurr1 gene. journal Gene volume 230 issue ... of the retinoid X receptor beta, nuclear related receptor 1, and peroxisome proliferator activated receptor alpha genes in schizophrenia and alcohol dependence possible haplotype association of nuclear related receptor 1 gene to alcohol dependence. journal Am. J. Med. Genet. volume 114 issue 1 ... T, et al. title Activation of nuclear orphan receptor NURR1 transcription by NF kappa B and cyclic ... cite journal author Kim KS, Kim CH, Hwang DY, et al. title Orphan nuclear receptor Nurr1 directly transactivates ... refend External links MeshName Nurr1 nuclear receptor PDB Gallery geneid 4929 Transcription ... 7705655 doi 10.1101 gad.9.7.769 url issn ref Retinoic acid receptor beta . ref name pmid7705655 References ... among nuclear hormone receptors. journal Cell volume 81 issue 4 pages 541 50 year 1995 pmid 7758108 ... immediate early response gene closely related to the steroid thyroid hormone receptor NAK1 ...   more details



  1. Translocator protein

    PBB geneid 706 Translocator protein TSPO is an 18 kDa protein mainly found on the outer mitochondrial membrane . It was first described as peripheral benzodiazepine receptor PBR , a secondary binding site for diazepam , but subsequent research has found the receptor to be expressed throughout the body ... TB, Lacap re JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M title Translocator protein 18kDa new nomenclature for the peripheral type benzodiazepine receptor based on its structure ... month August pmid 16822554 doi 10.1016 j.tips.2006.06.005 url issn ref In humans, the translocator protein ... receptor regional mapping of the gene and characterization of the receptor expressed from ... of a human peripheral type benzodiazepine receptor journal Eur. J. Biochem. volume 195 issue 2 pages ... JM, Drieu K title Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis ... receptor is essential for stress adaptation in plants journal Plant J. volume 51 issue 6 pages ... for the peripheral type benzodiazepine receptor journal Biochemical Pharmacology volume 52 pages 1805 ... author Tanimoto Yutaka coauthors Onishi, Yoshiaki year 1999 title Benzodiazepine Receptor Agonists ... title Translocator protein 18 kDa TSPO molecular sensor of brain injury and repair journal Pharmacology ... Y, Leschiner S, Spanier I, Lakomek M, Gavish M title Ligands of the mitochondrial 18 kDa translocator ... M title Channel like functions of the 18 kDa translocator protein TSPO regulation of apoptosis ... M, Putzolu M, Diaz G title Intracellular cholesterol changes induced by translocator protein 18 kDa ... C title Anxiolytic like effects of N,N dialkyl 2 phenylindol 3 ylglyoxylamides by modulation of translocator ... Translocator Protein Ligands as Promising Therapeutic Tools for Anxiety Disorders journal Current ... R, Holsboer F, Kucher K title Translocator Protein 18 kD as Target for Anxiolytics Without Benzodiazepine ... for imaging of inflammation. For example, the radioligand 3H PK 11195 has been used in receptor autoradiography ...   more details



  1. Nuclear receptor co-repressor 1

    PBB geneid 9611 The nuclear receptor co repressor 1 also known as thyroid hormone and retinoic acid receptor ... receptor mediated by a nuclear receptor co repressor journal Nature volume 377 issue 6548 pages ... which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylase s to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation ... 147 issue 4 pages 827 839 doi 10.1016 j.cell.2011.10.017 ref Interactions Nuclear receptor co repressor ... and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand ... D J, Leid M year 1999 month May. title Identification of nuclear receptor corepressor as a peroxisome ... Markus, Chait Brian T, Roeder Robert G year 2002 month Mar. title The N CoR HDAC3 nuclear receptor ... E A, Guenther M G, Kouzarides T, Lazar M A year 2000 month Jan. title Nuclear receptor corepressors ... S P, Torchia J year 2000 month Dec. title A novel nuclear receptor corepressor complex, N CoR, contains ... S, Zelent A year 1998 month Apr. title Reduced retinoic acid sensitivities of nuclear receptor ... of the dihydrotestosterone activated androgen receptor by nuclear receptor corepressor journal Mol ... Anthony N year 2005 month Feb. title The androgen receptor recruits nuclear receptor CoRepressor ... R, Jameson J L year 1998 month Dec. title The interaction of the vitamin D receptor with nuclear receptor ... JL title Nuclear receptor corepressors activate rather than suppress basal transcription of genes ... retinoic acid sensitivities of nuclear receptor corepressor binding to PML and PLZF RARalpha underlie ..., Xie W, et al. title Unique forms of human and mouse nuclear receptor corepressor SMRT. journal Proc ... cite journal author Nagaya T, Chen KS, Fujieda M, et al. title Localization of the human nuclear receptor .... title Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3 independent ... refend External links MeshName nuclear receptor corepressor 1 3 nuclear receptor corepressor ...   more details



  1. Aryl radical

    An Aryl radical in organic chemistry is an reactive intermediate and an arene compound incorporating one free radical carbon atom as part of the ring structure. As such it is the radical counterpart of the Arenium ion . The parent compound is the phenyl radical C sub 6 sub H sub 5 sub sup . sup ref Minireview Intermolecular Olefin Functionalisation Involving Aryl Radicals Generated from Arenediazonium Salts Markus R. Heinrich DOI 10.1002 chem.200801306 Chemistry A European Journal 2008 Volume 15 Issue 4, Pages 820 833 ref . Aryl radicals are intermediates in certain organic reaction s. Synthesis Aryl radicals can be obtained via aryl diazonium salt s. Alternatives for these salts are certain aryl triazene s and aryl hydrazine s. Aryl bromides and iodides can be converted to aryl radicals via tributyltin hydride and related compounds and silyl hydride s. Aryl halides can also be converted via electrosynthesis electrochemical cathodic reduction The mushroom Stephanospora caroticolor is suspected to generate an aryl radical as part of its biological chemical defence mechanism. Spectroscopy The parent phenyl radical has been identified via electron paramagnetic resonance and UV spectroscopy . Reactions Aryl radicals are very reactive and are found in many different reactions. Proton abstraction is considered a side reaction . Several reactions of synthetic utility in which aryl radicals feature are Halogen transfer reaction with electron deficient alkenes in the meerwein arylation biaryl coupling reaction couplings Sandmeyer reaction s addition to iminium ion s addition to sulfur dioxide References Reflist DEFAULTSORT Aryl Radical Category Reactive intermediates Category Free radicals ...   more details



  1. Aryl halide

    In organic chemistry , an aryl halide also known as haloarene or halogenoarene is an aromatic compound in which one or more hydrogen atoms directly bonded to an aromatic ring are replaced by a halide. The haloarene ... and properties. The most important members are the aryl chlorides, but the class of compounds ... routes to aryl halides are direct halogenation and via diazonium salts. ref name morrison cite ... iron III chloride or aluminium chloride . The most important aryl halide, chlorobenzene is produced ... . Aniline s aryl amines are converted to their diazonium salt s using nitrous acid . For example, copper I chloride converts diazonium salts to the aryl chloride. Nitrogen gas is the leaving group, which ... as the fluoride donor. Halogenation in nature Aryl halides occur widely in nature, most commonly ... pyrrole derivatives. Some of these naturally occurring aryl halides exhibit useful medicinal properties ... ref File Vancomycin.svg thumb 280px center center Vancomycin , an important antibiotic , is an aryl ... trends The C X distances for aryl halides follow the expected trend. These distances for fluorobenzene ... last1 Oberhammer first1 Heinz isbn 9780470682531 ref Reactions Aryl halides do not participate in conventional ... nucleophiles via reactions involving radical anions. Alternatively aryl halides, especially ... type reactions. Aryl halides react with metals to give more reactive derivatives that behaves as sources of aryl anions. Magnesium to give Grignard reagent s, which are useful in organic synthesis of other aryl compounds. Chlorobenzene was once the precursor to phenol , which is now made by oxidation of cumene . At high temperatures, aryl react with ammonia to give anilines. ref name Ullmann ... The aryl halides produced on the largest scale are chlorobenzene and the isomers of dichlorobenzene ... the herbicide Lasso. Overall, production of aryl chlorides as well as related naphthyl derivatives ... H sub 5 sub Cl PCl sub 3 sub 6 Na P C sub 6 sub H sub 5 sub sub 3 sub 6 NaCl Aryl bromides are widely ...   more details



  1. Aryl-acylamidase

    enzyme Name aryl acylamidase EC number 3.5.1.13 CAS number 9025 18 7 IUBMB EC number 3 5 1 13 GO code 0047680 image width caption In enzymology , an aryl acylamidase EC number 3.5.1.13 is an enzyme that catalysis catalyzes the chemical reaction an anilide H sub 2 sub O math rightleftharpoons math a carboxylate aniline Thus, the two substrate biochemistry substrates of this enzyme are anilide and water H sub 2 sub O , whereas its two product chemistry products are carboxylate and aniline . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is aryl acylamide amidohydrolase . Other names in common use include AAA 1 , AAA 2 , brain acetylcholinesterase is associated with AAA 2 , and pseudocholinesterase associated with arylacylamidase . References reflist 1 cite journal author Nimmo Smith RH date 1960 title Aromatic N deacylation by chick kidney mitochondria journal Biochem. J. volume 75 pages 284&ndash 293 pmid 14427286 pmc 1204423 issue 2 hydrolase stub Category EC 3.5.1 Category Enzymes of unknown structure Wickedpedia article ...   more details



  1. Hydrocarbon mixtures

    Unreferenced date December 2009 Orphan date October 2006 att June 2011 Hydrocarbon mixtures are a group of various Volatility chemistry volatile , highly flammable , mixtures used chiefly as nonpolar solvents . Composition Hydrocarbon mixtures are composed of petroleum ether s and other hydrocarbon s. Petroleum ether should not be confused with the class of organic compounds called ethers and equally, going under its alternative name of benzine , it should not be confused with benzene . Benzine is a mixture of alkanes , such as pentane , hexane , and heptane whereas benzene is a cyclic, aromatic hydrocarbon . A hydrocarbon is any chemical compound that consists only of the chemical element element s carbon C and hydrogen H . They all contain a carbon frame, and have hydrogen atoms attached to the frame. Often the term is used as a shortened form of the term aliphatic hydrocarbon . Most hydrocarbons are combustible . Petroleum ether is obtained from petroleum refineries as the portion of the distillate which is intermediate between the lighter naphtha and the heavier kerosene . It has a specific gravity of between 0.6 and 0.8 depending on its composition. DEFAULTSORT Hydrocarbon Mixtures Category Alkanes Category Hydrocarbon solvents ...   more details



  1. Aryl sulfotransferase

    enzyme Name aryl sulfotransferase EC number 2.8.2.1 CAS number 9026 09 9 IUBMB EC number 2 8 2 1 GO code 0004062 image width caption Pfam box Symbol Arylsulfotransferase Name Arylsulfotransferase Pfam PF05935 InterPro IPR010262 PROSITE PDB An aryl sulfotransferase EC number 2.8.2.1 is an enzyme that transfers a sulfate group from phenol phenolic sulfate ester s to a phenolic acceptor substrate ref name PUB00011921 cite journal author Kim SK, Baek MC, Kim DH, Kim BK, Choi EC title Cloning and sequencing of the Klebsiella K 36 astA gene, encoding an arylsulfate sulfotransferase journal Microbiol. Immunol. volume 40 issue 8 pages 531 537 year 1996 pmid 8887346 ref . 3 phosphoadenylyl sulfate a phenol math rightleftharpoons math adenosine 3 ,5 bisphosphate an aryl sulfate Thus, the two substrate biochemistry substrates of this enzyme are 3 phosphoadenylyl sulfate and phenol , whereas its two product chemistry products are adenosine 3 ,5 bisphosphate and aryl sulfate . These enzymes are transferase s, specifically the sulfotransferase s, which transfer sulfur containing groups. The systematic name of this enzyme class is 3 phosphoadenylyl sulfate phenol sulfotransferase . Other names in common use include phenol sulfotransferase , sulfokinase , 1 naphthol phenol sulfotransferase , 2 naphtholsulfotransferase , 4 nitrocatechol sulfokinase , arylsulfotransferase , dopamine sulfotransferase , p nitrophenol sulfotransferase , phenol sulfokinase , ritodrine sulfotransferase , and PST . This enzyme participates in sulfur metabolism . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1LS6 , PDB link 1Z28 , PDB link 1Z29 , PDB link 2A3R , and PDB link 2D06 . References reflist 1 Further reading refbegin cite journal author Romain Y, Demassieux S, Carriere S year 1982 title Partial purification and characterization of two isoenzymes involved in the sulfurylation of catecholamines ...   more details



  1. Unsaturated hydrocarbon

    Unreferenced date December 2009 Unsaturated hydrocarbon s are hydrocarbon s that have double or triple covalent bond s between adjacent carbon atom s. Those with at least one double bond are called alkene s and those with at least one triple bond are called alkyne s. Each double bond is represented by a number preceding the name of the base chain, representing on which hydrocarbon in the chain the double or triple bond can be found. Alkenes and alkynes with more than one double or triple bond respectively are named with the appropriate numeric prefix preceding the ene or yne . Examples of unsaturated hydrocarbon include 2,4 pentadiene and 2 butyne, among others. Unsaturated hydrocarbons with both double and triple bonds have the suffix enyne and are handled in a similar manner. The physical properties of unsaturated hydrocarbons are very similar to those of the corresponding saturated compounds. They are slightly soluble in water. Except for aromatic compounds , unsaturated hydrocarbons are highly reactive and undergo addition reaction s to their multiple bonds. Typical reagents added are hydrogen halide s, water , sulfuric acid , elemental halogen s and alcohols . Testing To test whether the hydrocarbon is unsaturated you should add bromine water. If the bromine water becomes decolourised Goes colorless then it is unsaturated.Mix water with saturated hydrocarbon as well as unsaturated hydrocarbon. Add some common salt to it. Unsaturated hydrocarbon with water makes salt dissolves and saturated hydrocarbon make its vice versa. See also saturated hydrocarbon DEFAULTSORT Unsaturated Hydrocarbon Category Hydrocarbons ar es Hidrocarburo insaturado hi lv Nepies tin tie og de ra i ja pl W glowodory nienasycone pt Hidrocarboneto insaturado ru zh ...   more details



  1. Hydrocarbon economy

    Hydrocarbon economy is a term referencing the global hydrocarbon industry and its relationship to world markets. world energy resources and consumption energy used mostly comes from three hydrocarbon s petroleum , coal , and natural gas . Hydrocarbon economy is often used when talking about possible alternatives like the hydrogen economy . ref http scholar.google.com scholar?q 22hydrocarbon economy 22&hl en&lr &start 30&sa N ref ref http www.google.com search?tab sw&sa N&q 22hydrocarbon economy 22&hl en&lr &sa N ref References reflist Category Energy economics Category Economies ...   more details



  1. Hydrocarbon keratosis

    A hydrocarbon keratosis also known as Pitch keratosis, Tar keratosis, and Tar wart is a Precancerous condition precancerous Keratosis keratotic skin lesion that occurs in people who have been occupationally exposed to polycyclic aromatic hydrocarbon s. ref name Fitz2 Freedberg, et. al. 2003 . Fitzpatrick s Dermatology in General Medicine . 6th ed. . McGraw Hill. ISBN 0071380760. ref rp 728 References reflist Diseases of the skin and subcutaneous tissue Category Dermatologic terminology Category Epidermal nevi, neoplasms, cysts Epidermal growth stub ...   more details



  1. Unburned hydrocarbon

    Unreferenced date December 2009 Unburned hydrocarbons UHCs are the hydrocarbon s emitted after petroleum is burned in an engine. Any fuel entering a flame will be reacted. Dubious Running rich date July 2010 Thus, when unburned fuel is emitted from a combustor , the emission is caused by fuel avoiding the flame zones. For Category Fossil fuels Category Hydrocarbons ...   more details



  1. Hydrocarbon plant

    Hydrocarbon plants or petroleum plants are plants which produce terpenoid s as secondary metabolite s in sufficient quantities to make it economically feasible to convert their dry mass to gasoline like fuels. Nobel laureate Melvin Calvin has studied the terpenoid terpene biosynthetic pathway s of a number of species of plants to study and quantify this property in various species. Species include latex producing members of the Euphorbiaceae family that cannot be tapped for their liquid latex such as Euphorbia lathyris and Euphorbia tirucalli E. tirucalli . ref name Kalita2008 cite journal last1 Kalita first1 D title Hydrocarbon plant New source of energy for future journal Renewable and Sustainable Energy Reviews volume 12 issue 2 year 2008 pages 455 471 issn 13640321 doi 10.1016 j.rser.2006.07.008 ref ref name Ramawat2010 cite book author K. G. Ramawat title Desert Plants Biology and Biotechnology url http books.google.com books?id UNaNWN4zkqQC&pg PA37 accessdate 23 August 2010 year 2010 publisher Springer isbn 9783642025495 pages 37 ref See also Biogasoline Energy crop Asclepias References reflist bioenergy Category Biofuels material stub ...   more details




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