PBB geneid 675 Infobox protein family Symbol BRCA2 Name BRCA2 repeat image PDB 1n0w EBI.jpg width caption crystal structure of a rad51 brca2 brc repeat complex Pfam PF00634 Pfam clan InterPro IPR002093 ... 2 helical Name BRCA 2 helical image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 complex ... CAZy CDD Infobox protein family Symbol BRCA 2 OB1 Name BRCA2, oligonucleotide oligosaccharide binding, domain 1 image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 complex Pfam PF09103 ... protein family Symbol BRCA 2 OB3 Name BRCA2, oligonucleotide oligosaccharide binding, domain 3 image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 complex Pfam PF09104 Pfam clan InterPro ... Symbol Tower Name Tower domain image PDB 1miu EBI.jpg width caption structure of a brca2 dss1 ... protein CAZy CDD Unsourced image removed Image BRCA Genes location of BRCA1 and BRCA2 on chromosomes 13 and 17.gif thumb right Location of the genes BRCA1 and BRCA2 on chromosomes 13 and 17 BRCA2 Breast Cancer 2 susceptibility protein is a protein that in humans is encoded by the BRCA2 gene . ref name ..., BRCA2, to chromosome 13q12 13 journal Science volume 265 issue 5181 pages 2088 90 year 1994 month September pmid 8091231 doi 10.1126 science.8091231 url ref BRCA2 orthologs have been identified in most ... phylogenetic marker BRCA2 coding sequence url http www.orthomam.univ montp2.fr orthomam data cds detailMarkers ENSG00000139618 BRCA2.xml ref BRCA2 belongs to the tumor suppressor gene family ref name pmid10193517 cite journal author Duncan JA, Reeves JR, Cooke TG title BRCA1 and BRCA2 proteins roles ... 51 5 237 ref ref name pmid15546503 cite journal author Yoshida K, Miki Y title Role of BRCA1 and BRCA2 ... ref The BRCA2 gene is located on the long q arm of chromosome 13 human chromosome 13 at position ... of the BRCA1 and BRCA2 genes are very different, at least some functions are interrelated. The protein s made by both gene s are essential for repairing damaged DNA. The BRCA2 protein binds to and regulates ... more details
wiktionarypar BRCA BRCA may refer to BRCA mutation , mutations in two genes which produce a hereditary breast ovarian cancer syndrome BRCA1 BRCA2 British Radio Car Association , an organisation governing all types of radio controlled car racing in the United Kingdom. disambig it BRCA pl BRCA ... more details
PBB geneid 79728 Partner and localizer of BRCA2 , also known as PALB2 , is a protein which in humans is encoded by the PALB2 gene . ref name entrez cite web title Entrez Gene PALB2 partner and localizer of BRCA2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 79728 accessdate ref ref name pmid16793542 cite journal author Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM title Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2 journal Mol. Cell volume 22 issue 6 pages 719 29 year 2006 month June pmid 16793542 doi 10.1016 j.molcel.2006.05.022 url ref ref name pmid17200672 cite journal author Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, Pals G, Errami A, Gluckman E, Llera ... in the BRCA2 partner PALB2 journal Nat. Genet. volume 39 issue 2 pages 159 61 year 2007 month February ... with the breast cancer 2 early onset protein BRCA2 in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. ref name entrez PALB2 binds the single ... A.M, et al. title Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous ... pmid 20871615 volume 17 issue 10 pages 1247 54 ref PALB2 can function synergistically with a BRCA2 ... BRCA2 in stimulating homologous recombination. journal Nature Structural & molecular biology ... of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. journal ... Biallelic mutations in PALB2 also known as FANCN , similar to biallelic BRCA2 mutations, cause Fanconi ... gr.4039406 pmc 1356129 cite journal author Xia B, Sheng Q, Nakanishi K, et al. title Control of BRCA2 ... N, Seal S, Thompson D, et al. title PALB2, which encodes a BRCA2 interacting protein, is a breast cancer ... author Xia B, Dorsman JC, Ameziane N, et al. title Fanconi anemia is associated with a defect in the BRCA2 ... journal author Oliver AW, Swift S, Lord CJ, et al. title Structural basis for recruitment of BRCA2 ... more details
original research date October 2010 unreferenced date October 2010 Microcalcifications are tiny specks of mineral deposit s calcium , that can be scattered throughout the mammary gland , or occur in clusters. When found on a mammogram , a radiologist will then decide whether the specks are of concern usually, this is not the case. Commonly, they simply indicate the presence of tiny benign cyst s, but can signify the presence of early breast cancer for this reason, it is important to attend regular screening sessions, as recommended by your health service. They are caused by a number of reasons Aging the majority of diagnoses are made in women over 50 Benign causes Genetic involving the BRCA1 and BRCA2 genes Depending on what pattern the microcalcifications present determines the future course of the action, whether it be further investigatory techniques as part of the triple assessment , or more regular screening. Category Medical signs Med sign stub ... more details
A BRCA mutation is a mutation in either of the genes BRCA1 and BRCA2 . Harmful mutations in these genes produce a hereditary breast ovarian cancer syndrome in affected families. Mutations in BRCA1 and BRCA2 ... breast cancer , ovarian cancer and certain other cancers. Why BRCA1 and BRCA2 mutations leads preferentially .... Women with harmful mutations in either BRCA1 or BRCA2 have risk of breast cancer that is about ... BRCA title BRCA1 and BRCA2 Cancer Risk and Genetic Testing date 29 May 2009 ref BRCA1 mutations typically confer a higher risk of breast and ovarian cancer in women than BRCA2 mutations. Having a high ... pmid15546503 cite journal author Yoshida K, Miki Y title Role of BRCA1 and BRCA2 as regulators of DNA ... disable the gene or the protein that it produces. The cancer risk caused by BRCA1 and BRCA2 ... Easton, DF author7 Giles, GG author8 McCredie, MR author9 Hopper, JL title After BRCA1 and BRCA2 what ... the entire sequence of both BRCA1 and BRCA2 can be performed. In some cases, ethnicity can be used .... ref name Morris13 Breast and ovarian cancer risk See BRCA1 BRCA2 Women with deleterious mutations in either the BRCA1 or BRCA2 genes have a high risk of developing breast cancer breast and or ovarian ... 70. Approximately 40 to 57 of women with a deleterious mutation in BRCA2 will develop breast cancer ... Cite journal last1 Chen first1 S. last2 Parmigiani first2 G. title Meta analysis of BRCA1 and BRCA2 ... decades earlier than normal. ref name Morris5 BRCA2 is associated primarily with post menopausal breast ... ages, but the risk for women with BRCA2 climbs markedly at or shortly after menopause. ref name ... with a BRCA2 mutation and no screening or medical interventions who die before age 70 will die from ... label2 BRCA2 mutation data2 71 label3 Typical woman data3 84 A 25 year old woman with no mutation ... cancer, and 28 other causes. ref name Kurian 2009 Women with high risk BRCA2 mutations, with screening ... 70. Approximately 6 of men with a BRCA2 mutation will develop breast cancer by age 70, which is approximately ... more details
PBB geneid 56647 BRCA2 and CDKN1A interacting protein is a protein that in humans is encoded by the BCCIP gene . ref name pmid11313963 cite journal author Liu J, Yuan Y, Huan J, Shen Z title Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2 journal Oncogene volume 20 issue 3 pages 336 45 year 2001 month Apr pmid 11313963 pmc doi 10.1038 sj.onc.1204098 ref ref name pmid10878006 cite journal author Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi Ariga SM, Ariga H title TOK 1, a novel p21Cip1 binding protein that cooperatively enhances p21 dependent inhibitory activity toward CDK2 kinase journal J Biol Chem volume 275 issue 40 pages 31145 54 year 2000 month Oct pmid 10878006 pmc doi 10.1074 jbc.M003031200 ref ref name entrez cite web title Entrez Gene BCCIP BRCA2 and CDKN1A interacting protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 56647 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple ... may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity .... ref name entrez Interactions BCCIP has been shown to Protein protein interaction interact with BRCA2 ... conserved nuclear protein that interacts with BRCA2 journal Oncogene volume 20 issue 3 ... Machackova E, Damborsky J, Valik D, Foretova L title Novel germline BRCA1 and BRCA2 mutations in breast ... A, Konstantopoulou I, et al. title BRCA2 gene mutations in Greek patients with familial breast cancer ... cite journal author Robson M, Scheuer L, Nafa K, et al. title Unique de novo mutation of BRCA2 in a woman ... The BRCA2 interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational ... more details
is also found to interact with BRCA1 and BRCA2 , which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. ref cite journal author Daniel DC title Highlight BRCA1 and BRCA2 ... cancer susceptibility protein BRCA2 controls the function of Rad51 in the pathway for DNA repair ... of a RAD51 BRCA2 complex journal Nature volume 420 issue 6913 pages 287 93 year 2002 pmid 12442171 ... 0300985810390826 ref ref cite journal author Klopfleisch R, Gruber AD. title Increased expression of BRCA2 ... 2003 month November title Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome ... ref BRCC3 , ref name pmid14636569 BARD1 , ref name pmid14636569 BRCA2 , ref name pmid14636569 ... Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 journal ... title M phase specific phosphorylation of BRCA2 by Polo like kinase 1 correlates with the dissociation of the BRCA2 P CAF complex journal J. Biol. Chem. volume 278 issue 38 pages 35979 87 publisher ... of Rad51 recombinase by self association and interaction with BRCA2 journal Mol. Cell volume 12 ... J, Sharp Z D, Lee W H year 1998 month April title The BRC repeats in BRCA2 are critical for RAD51 ... Master S R, Huber L J, Ha S I, Chodosh L A year 2001 month October title Analysis of murine Brca2 ... conserved BRC motifs in the human breast cancer susceptibility gene brca2 journal ... possible sites of BRCA2 interacting with DNA repair protein RAD51 journal Genes Chromosomes Cancer ... BRCA2 complex journal Nature journal Nature volume 420 issue 6913 pages 287 93 publisher location ..., an evolutionarily conserved nuclear protein that interacts with BRCA2 journal Oncogene ... month September title Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor ... more details
NCN Route 11 is a Sustrans National Cycle Route connecting Harlow in Essex to King s Lynn in Norfolk . Route Harlow to Cambridge Image National Cycle Route 11 at Great Shelford.jpg thumb NCR 11 near Great Shelford, showing a double helix and a small part of the BRCA2 gene. Harlow Bishop Stortford Hinxton Sawston Cambridge Intersects with NCR 51 in Cambridge. A section of path, about two kilometres long, from Great Shelford to Addenbrookes Hospital in Cambridge, is decorated with over 10,000 lines of four colours representing the nucleotide sequence of the BRCA2 gene. This gene, implicated in early onset breast cancer, was discovered in 1994 the discoverers included scientists from nearby Addenbrookes Hospital and The Sanger Centre, Hinxton. This section of path also includes and commemorates the 10,000th mile of the National Cycle Network. Cambridge to King s Lynn Cambridge Burwell, Cambridgeshire Burwell Wicken, Cambridgeshire Wicken Ely, Cambridgeshire Ely Downham Market Watlington, Norfolk Watlington King s Lynn Intersects with National Cycle Route 1 near King s Lynn Expand section date June 2008 Proposed development Wicken Fen Vision Spine Route main Wicken Fen Lodes Way Route 11 between Cambridge and Ely had a gap in the route, due to the difficulties of crossing the many waterways of the Cambridgeshire Fens. In 2011, the new bridge over Swaffham Bulbeck Lode, and surfacing of several sections of cycle path enables complete use of the route. This section of route 11 had been called the Wicken Fen Vision Spine Route, but in 2011 was named the Lodes Way. The project involves the construction of 18 km of cycleway and of a number of bridges over the man made waterways known as Cambridgeshire Lodes lodes . ref name WFV2 cite web url http www.wicken.org.uk vision lodesway.htm title The Wicken Vision Spine Route publisher National Trust for Places of Historic Interest or Natural Beauty National Trust date accessdate 2011 12 30 ref The Lodes Way still has a foot b ... more details
to form in this way, and in tumours with BRCA1 , BRCA2 or PALB2 ref name Buisson 2010 cite journal ... BRCA2 in stimulating homologous recombination. journal Nature Structural & molecular biology doi ... t replicate their DNA as often as cancer cells, and that lacks any mutated BRCA1 or BRCA2 still ... breaks from the single strand breaks generated by the radiotherapy in tumor tissue with BRCA1 BRCA2 ... more details
PBB geneid 56946 Protein EMSY is a protein that in humans is encoded by the C11orf30 gene . ref name entrez cite web title Entrez Gene C11orf30 chromosome 11 open reading frame 30 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 56946 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions C11orf30 has been shown to Protein protein interaction interact with ZMYND11 , ref name pmid14651845 cite journal last Hughes Davies first Luke authorlink coauthors Huntsman David, Ruas Margarida, Fuks Francois, Bye Jacqueline, Chin Suet Feung, Milner Jonathon, Brown Lindsay A, Hsu Forrest, Gilks Blake, Nielsen Torsten, Schulzer Michael, Chia Stephen, Ragaz Joseph, Cahn Anthony, Linger Lori, Ozdag Hilal, Cattaneo Elena, Jordanova E S, Schuuring Edward, Yu David S, Venkitaraman Ashok, Ponder Bruce, Doherty Aidan, Aparicio Samuel, Bentley David, Theillet Charles, Ponting Chris P, Caldas Carlos, Kouzarides Tony year 2003 month Nov. title EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer journal Cell volume 115 issue 5 pages 523 35 publisher location United States issn 0092 8674 pmid 14651845 bibcode oclc id url language format accessdate laysummary laysource laydate quote doi 10.1016 S0092 8674 03 00930 9 ref BRCA2 ref name pmid14651845 and CBX1 . ref name pmid14651845 References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Hughes Davies L, Huntsman D, Ruas M, et al. title EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer journal Cell volume 115 issue 5 pag ... more details
risk. He was a key part of the team that in 1995 discovered the gene BRCA2, which is linked to an increased ... identified a way to exploit genetic weaknesses in cancer cells including mutated BRCA 1 or BRCA2, leading to a new approach to cancer treatment. Cancer cells that carry mutant forms of BRCA1 or BRCA2 ... more details
Chembox ImageFile Rucaparib.svg ImageSize 200px IUPACName 8 Fluoro 2 4 methylamino methyl phenyl 1,3,4,5 tetrahydro 6 H azepino 5,4,3 cd indol 6 one OtherNames AG014699 Section1 Chembox Identifiers CASNo 283173 50 2 CASNo Ref cascite correct CAS PubChem 9931954 ChemSpiderID 8107584 SMILES Fc4cc2c1c nc c1CCNC2 O c3ccc cc3 CNC c4 InChI InChI 1S C19H18FN3O c1 21 10 11 2 4 12 5 3 11 18 14 6 7 22 19 24 15 8 13 20 9 16 23 18 17 14 15 h2 5,8 9,21,23H,6 7,10H2,1H3, H,22,24 Section2 Chembox Properties C 19 H 18 F 1 N 3 O 1 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Rucaparib AG 014699 is a PARP inhibitor being investigated as a potential anti cancer agent. Rucaparib inhibits the contraction of isolated vascular smooth muscle, including that from the tumours of cancer patients. It also reduces the migration of some cancer and normal cells in culture. ref http www.qub.ac.uk schools SchoolofPharmacy Filestore Filetoupload,121186,en.pdf ref It can be taken orally in tablet form. ref name CRJan2011 cite web url http www.netdoctor.co.uk interactive news cancer research launches new drug trial id801261464 t116.html title Cancer Research launches new drug trial date 11 Jan 2011 ref It has undergone phase I clinical trial s for patients with advanced solid tumour s. ref cite web url http meeting.ascopubs.org cgi content abstract 23 16 suppl 3065 title First in human phase I trial of the PARP inhibitor AG 014699 with temozolomide TMZ in patients pts with advanced solid tumors ref It is in phase II clinical trials for metastatic breast cancer breast and ovarian cancer with known BRCA1 or BRCA2 mutation. ref http science.cancerresearchuk.org research loc newcastle newcastle univ plummerr plummerrfr plummerrfrp2 ?version 1 URL no longer relevant ref ref name CRJan2011 References reflist Category PARP inhibitors Category Indoles Category Lactams antineoplastic drug stub ... more details
Olufunmilayo I. Olopade born 1957 Nigeria is an hematology oncologist , Associate Dean for Global Health and Walter L. Palmer Distinguished Service Professor in Medicine and Human Genetics at the University of Chicago . ref http www.uchospitals.edu physicians olufunmilayo olopade.html ref ref http www.genes.uchicago.edu olopade.html ref She also serves as director of the University of Chicago Hospital s Cancer Risk Clinic. She graduated from University of Ibadan , Nigeria, with a MD, in 1980. She has performed extensive clinical work surrounding the role of the BRCA1 and BRCA2 genes in the incidence of breast cancer in women of African descent. She a member of the American Association for Cancer Research, the American College of Physicians, and the Nigerian Medical Association and works closely with the Breast Cancer Research Foundation. ref http www.bcrfcure.org action 0708grantees olopade.html ref ref http www.bcrfcure.org action 0910grantees olopade.html ref She is a member of the Institute of Medicine . ref http www.iom.edu Global Directory Detail.aspx?id 0020018661 ref She married Christopher Sola Olopade, also a physician at the University of Chicago, in 1983 they have two daughters, and one son. ref http www.notablebiographies.com newsmakers2 2006 Le Ra Olopade Olufunmilayo.html ref Awards 2005 MacArthur Fellows Program ref http www.macfound.org site c.lkLXJ8MQKrH b.1076861 apps nl content2.asp?content id D26D83CB 8210 4530 868D 92480C62AEA0 ¬oc 1 ref References reflist External links http scicom.ucsc.edu QandA AAAS08 Olopade The SciCom Interview Olufunmilayo Olopade http www.pbs.org kcet tavissmiley archive 200907 20090710 olopade.html Dr. Olufunmilayo Olopade , Tavis Smiley , July 10, 2009 http www.portofharlem.net archives coverstories febapr2008.html Is the Answer in Your Genes? , Port of Harlem , Feb Apr 2008 http www.sciencedaily.com releases 2008 03 080317164342.htm Breast Cancer In Black Women May Be Connected To Neighborhood Conditions, Study Sugg ... more details
Infobox scientist name Bruce Ponder image Replace this image male.svg Freely licenced images only. Please do not put a fair use image here, it will be deleted see WP NONFREE image size caption Do you have a picture of Bruce Ponder? Please, post here. birth name birth date birth place nationality British field work institution University of Cambridge alma mater doctoral advisor Lionel Crawford doctoral students notable students other names known for occupation prizes Knight Bachelor , Fellow of the Royal Society FRS Professor Sir Bruce Ponder is the Director and Professor of Oncology at the Cambridge Bio Medical Campus Cancer Research UK Cambridge Research Institute Cancer Research UK Cambridge Research Institute . Ponder s team helped to identify the breast cancer susceptibility genes BRCA1 and BRCA2 . He is the director of the Gurdon Institute . He carried out his PhD studies with Lionel Crawford in London working on chromatin organisation and DNA sequence specificity using polyoma virus . ref name pmid202734 cite journal author Ponder BA, Crew F, Crawford LV title Comparison of nuclease digestion of polyoma virus nucleoprotein complex and mouse chromatin journal J. Virol. volume 25 issue 1 pages 175 86 year 1978 month January pmid 202734 pmc 353914 doi url ref External references http www.jesus.cam.ac.uk contacts fellows profiles ponder.html Page at Jesus college Cambridge http info.cancerresearchuk.org cancerandresearch ourcurrentresearch researchbygrantee prof bruce ponder Page at Cancer Research UK References Reflist Persondata Metadata see Wikipedia Persondata . NAME Ponder, Bruce ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Ponder, Bruce Category Fellows of the Royal Society Category Knights Bachelor Category Cancer research Category Living people ... more details
hand split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2 ... been shown to Protein protein interaction interact with BRCA2 . ref name pmid10373512 cite journal ... gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals journal Mol. Cell. Biol ... Nikola P year 2002 month Sep. title BRCA2 function in DNA binding and recombination from a BRCA2 ... of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from ... first4 D last5 Marshall first5 CJ last6 Ashworth first6 A cite journal author Yang H title BRCA2 function in DNA binding and recombination from a BRCA2 DSS1 ssDNA structure journal Science volume ... more details
high throughput sequencing by Myriad 1995 BRCA2 was resequenced based on unpublished insider ... First BRCA2 patent filed in the U.S. by the University of Utah and other institutions 1996 Myriad ... First BRCA2 patent was granted in the U.S. to the University of Utah, NIEHS and Myriad Genetics 2000 ... for Sick Children University of Toronto University of Tokyo Myriad Genetics, Inc. BRCA2 Co discoverers ... first John last Timmer accessdate 2009 11 10 ref Parts of the company s patents on the BRCA1 and BRCA2 ... more details
publisher Health and Life ref It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations ... Brca2 p53 mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin journal ... cancer s caused by mutations of the BRCA1 and BRCA2 genes. In 12 of the patients, none of whom ... is promising for women with ovarian cancer. 7 responses in 17 patients with BRCA1 or BRCA2 ... more details
O, Cummings S, Garber J, Bernhardt B, Antman K, et al Sequence analysis of BRCA1 and BRCA2 Correlation ... Jewish women for BRCA1 and BRCA2. J Clin Oncol 1999 17 494 500. Antman K, Heitjan D, Hortobagy Gabriel ... in both BRCA1 and BRCA2 Clin Genet 2000 57 70 73. Antman, K, S Lagakos, J Drazen. Designing and Funding ... more details
en icon b r k ref cite web url http www.healthcentral.com breast cancer c 78 9925 brca1 brca2 title BRCA1 and BRCA2 No Longer the Only Troublesome Genes Out There accessdate 2010 07 02 ref breast ... pmid16108063 cite journal author Henderson BR title Regulation of BRCA1, BRCA2 and BARD1 intracellular ... meiosis . The BRCA2 protein, which has a function similar to that of BRCA1, also interacts with the RAD51 ... with BRCA1 or BRCA2 gene mutations & 124 SciVee author Friedenson B date 2012 02 13 format ... suggests that both the BRCA1 and BRCA2 proteins regulate the activity of other genes and play ... BRCA1 or BRCA2 gene have up to a 60 risk of developing breast cancer by age 90 increased ... with BRCA2 mutations. ref http www.breastcancer.org risk genetic bcrisk abnrml genes.jsp Breastcancer.org ... and BRCA2 genes journal Hum Mutat. year 2005 pages 415 22 volume 25 issue 5 pmid 15832305 doi ... containing BRCA1 and BRCA2 greatly increase risks for a subset of leukemias and lymphomas. ref name pmid17683622 Women having inherited a defective BRCA1 or BRCA2 gene have risks for breast and ovarian ... suppressors beyond BRCA1 or BRCA2. A major advantage of this model is that it suggests there may be some ... in carriers of mutations in BRCA1, BRCA2, ATM or Fanconi anemia genes journal Journal of Medicine and Medical ... first SA last Narod coauthors Foulkes, WD. title BRCA1 and BRCA2 1994 and beyond journal Nature ..., L. title Mutation analysis of the BRCA1 and BRCA2 genes in the Belgian patient population and identification ... BRCA2 mutations in 517 Dutch breast and or ovarian cancer families journal European Journal of Cancer ..., R. title Evidence of founder mutations in Finnish BRCA1 and BRCA2 families journal American Journal ..., H Krahe, R Holli, K Kere, J. title Involvement of BRCA1 and BRCA2 in breast cancer in a western ... Provencher, D. title Founder BRCA1 and BRCA2 mutations in French Canadian ovarian cancer cases unselected ..., D Haites, NE Fountzilas, G Pandis, N Yannoukakos, D. title Germ line BRCA1 and BRCA2 mutations in Greek ... more details
BLP IMDB refimprove date May 2010 Infobox person image only free content images are allowed for depicting living people. Non free and fair use images, e.g. promo photos, CD DVD covers, posters, screen captures, etc., will be deleted see WP NONFREE imagesize 150px name Greg Rikaart birth date birth date and age 1977 02 26 birth place Brooklyn, New York , United States U.S. website emmyawards Daytime Emmy Award for Outstanding Supporting Actor in a Drama Series Outstanding Supporting Actor in a Drama Series br 2005 The Young and the Restless Gregory Andrew Rikaart born February 26, 1977 is an United States American actor , currently on the cast of the soap opera The Young and the Restless , playing Kevin Fisher since July 2003. Biography Rikaart was born in Brooklyn, New York and grew up in Staten Island, New York . He graduated with honors from Villanova University in Pennsylvania. While in college, he spent a semester in Washington, D.C. , as an intern for a congressman on Capitol Hill . Rikaart won the Daytime Emmy for Outstanding Supporting Actor in 2005. Roles Felicity TV series Felicity Art Student 1999 episode Portraits Strong Medicine Traylor 2000 episode BRCA2 Gilmore Girls Kid 4 2000 episode Rory s Birthday Parties Grounded for Life Jason 2001 episode Dream on That s Life 2000 TV series That s Life Waiter 2001 episode Sex in the Suburbs As If Josh 2002 episode Alex s POV Dawson s Creek David 2002 2003 7 episodes Prey for Rock & Roll Scott 2003 X2 film X2 Museum Teenager 2 2003 Fake Stacy Josh Patterson 2003 The Young and the Restless Kevin Fisher July 2003 present The Closer Craig Sherman 2005 episode L.A. Woman Wannabe film Wannabe Trevor FYI 2005 CSI Miami Scott LeBrock 2007 episode Chain Reaction Imaginary Bitches Mark 2008 episode It s Totally What You Think Seeds 2009 film Seeds Paul 2009 Awards and nominations Daytime Emmys Winner, Outstanding Supporting Actor 2005 Daytime Emmys Nomination, Outstanding Supporting Actor 2005, 2006, 2007, 2008 Daytime Em ... more details
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