- Burantashi
Orphan date February 2009 refimprove date March 2009 Burantashi literally penis get up is a native Hausa people Hausa Fulani powder derived from the bark of the African tree Pausinystalia yohimbe . Burantashi is used as a food additive to barbecued meat suya in Nigeria , especially the Northern parts. The extracts contain the alkaloid yohimbine , an Alpha 2 adrenergic receptor alpha sub 2 sub receptor antagonist antagonist that has been used widely with variable success in erectile dysfunction , but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in Lagos, Nigeria was extracted aqueously and studied on the renal circulation of Sprague Dawley rat s. ref name Ajayi Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague Dawley rats. Methods. Find. Expt. Clin. Pharmacol . 2003, 25 10 817 22. ref In the in vivo study, the extract code named CCD X , caused a rise in mean arterial pressure MAP , and a rise in renal medullary blood flow MBF . This systemic vasoconstrictor and renal medullary dilator action was attenuated separately by the endothelin A receptor blocker BMS 182874, ET B blocker BQ788, but blocked by their combination ref name Ajayi . Further, the nitric oxide inhibitor NO , L Nomega nitro Arginine Methyl Ester L NAME 10 mg kg totally inhibited the rise in medullary blood flow due to CCD X. In vitro studies in isolated perfused kidneys IPK and in pressurised microvessels PMV confirmed the in vivo effect to cause vasoconstriction , which was inhibited by endothelin A and B antagonists. The pressor dose response characteristic of CCD X on PMV was similar to that of endothelin 1 with EC sub 50 sub close to 100ng. It was concluded from these studies that, the aqueous ... of Burantashi can be effectively evaluated. See also Sani Abacha References reflist External links ... more details
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