Double Negative may refer to Double negative , concept in linguistics Double negative elimination , logic theory Double negation , logic theory p p when extended to infinite collections it is disallowed in intuitionistic logic also considered by some to be one of the Laws of Thought The G del Gentzen negative translation in proof theory Film Deadly Companion , 1980 film also known as Double Negative Double Negative 1985 film Double Negative 1985 film Double Negative 2010 film Double Negative 2010 film Music Double Negative , 2004 album by The Muffins Double Negative band , hardcore punk band based in North Carolina Double Negative , a single release from British art rock band Grammatics Acronyms Metamaterial Classes of metamaterials Double negative metamaterial DNG , a material with both permittivity and permeability less than zero, commonly called a metamaterial Double negative DN T cell s, also called CD4 CD8 Other Double Negative artwork , 1969 artwork on the Mormon Mesa in Nevada Double Negative A Vicky Bauer Mystery , a 1988 book by Leona Gom Double Negative VFX , London based visual effects facility See also Double disambiguation Negative disambiguation Negative double , a bridge game move disambig ... more details
Infobox album See Wikipedia WikiProject Albums Name Studio Z nd 40 Ans d volution Type Compilation Artist Magma band Magma Cover Released 2009 Genre Zeuhl , Progressive rock Last album K.A. Kohntarkosz Anteria br 2004 This album Studio Z nd br 2009 All of Magma band Magma s studio albums up to and including 2004 s K.A. have been officially reissued on CD by Seventh Records. They were released in a 12 disc box set called Studio Z nd 40 Ans d volution, which as a bonus featured the exclusive double CD Archiw I & II, a compilation of unreleased material, including the 1970 film soundtrack for 24 heures seulement , an alternate version of Mekan k Destrukt w Kommand h , the band s first demo recordings from 1970 taken from an acetate disc , and an alternate take of Eliphas Levi from Merci. Albums are not remastered. Tracklisting CD1&2 Magma album Koba a br CD3 1001 Centigrades br CD4 Mekan k Destrukt w Kommand h br CD5 K hntark sz br CD6 urdah tah br CD7 d W d br CD8 Attahk br CD9 Merci Magma album Merci br CD10 K.A. Kohntarkosz Anteria br CD11&12 Archiw I & II Lineup Check the individual album pages for each album s lineup. Magma Category Magma albums ... more details
. Additional suppressor T cell populations include Tr1, Th3, CD8 sup sup CD28 sup sup , and Qa 1 restricted ... as CD4 CD8 T cell receptor TCR cells at the DN double negative stage, where an individual cell will rearrange ... complex MHC . If they receive these signals, they proliferate and express both CD4 and CD8 ... subjects with a history of leishmania infection suggest that modulation of CD8 suppressor T cells is, at least ... of large amounts of interferon gamma and lymphotoxin. CD8 T suppressor cells predominate in patients ... from skin test positive adults killed CD8 T cells but not CD4 helper T cells when added to culture ... test positive adults prevented CD8 suppressor T cell mediated increases in interleukin 10 secretion ... that kill or down regulate CD8 T suppressor cells. Once the leishmania infection has been eliminated and leishmania antigens are gone, CD8 T suppressor cells down regulate CD4 T helper cells. Isolation of cytokines that inhibit and kill CD8 T suppressor cells might be useful in treating diseases ... appears to be a minor population of MHC class I restricted CD8 sup sup Foxp3 expressing regulatory ... more details
of HLA I molecules which correlate with IFN mediated activation of memory CD8 cells and increased cytolytic action against virally infected cells and tumour cells via cytotoxic CD8 cells. References ... more details
Primary sources article date April 2010 Nicholas P. Restifo born in Ohio, 1960 is an American physician, artist , and immunologist . He is presently a tenured senior investigator in the intramural National Cancer Institute of the National Institutes of Health at Bethesda, Maryland . ref cite web url http ccr.cancer.gov staff staff.asp?profileid 5762 title Nicholas P. Restifo, M.D. publisher National Cancer Institute date September 12, 2009 accessdate April 14, 2010 Self published inline date April 2010 ref Dr. Restifo and his research team have made contributions to the fields of tumor immune escape, ref cite journal author Restifo NP, Esquivel F, Kawakami Y, et al. title Identification of human cancers deficient in antigen processing journal The Journal of Experimental Medicine volume 177 issue 2 pages 265 72 year 1993 month February pmid 8426105 pmc 1950463 doi 10.1084 jem.177.2.265 ref ref cite journal author Khong HT, Restifo NP title Natural selection of tumor variants in the generation of tumor escape phenotypes journal Nature Immunology volume 3 issue 11 pages 999 1005 year 2002 month November pmid 12407407 pmc 1508168 doi 10.1038 ni1102 999 ref virally encoded cancer vaccine s, ref cite journal author Irvine KR, McCabe BJ, Rosenberg SA, Restifo NP title Synthetic Oligonucleotide Expressed by a Recombinant Vaccinia Virus Elicits Therapeutic CTL journal Journal of Immunology volume 154 issue 9 pages 4651 7 year 1995 month May pmid 7722317 pmc 1976247 url http www.jimmunol.org cgi pmidlookup?view long&pmid 7722317 ref adoptive cell transfer for the treatment of cancer, and the biology of self tumor reactive T cells, with an emphasis on memory CD8 T cells. ref cite journal doi 10.1038 nm.1982 laysummary http www.emaxhealth.com 2 51 31732 stem immune cells destroy large tumors mice.html laysource EmaxHealth laydate June 15, 2009 title Wnt signaling arrests effector T cell differentiation and generates CD8 memory stem cells year 2009 last1 Gattinoni first1 Luca la ... more details
Infobox disease Name CD25 deficiency Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM 606367 MedlinePlus eMedicineSubj eMedicineTopic MeshID CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the IL 2 receptor interleukin 2 receptor alpha CD25 IL2RA gene. The mutations cause Gene expression expression of a defective chain or complete absence thereof, an essential part of high affinity interleukin 2 IL 2 receptors. The result is a syndrome described as IPEX syndrome IPEX like ref name Caudy2007 cite journal title CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X linked like syndrome, and defective IL 10 expression from CD4 lymphocytes journal J Allergy Clin Immunol year 2007 volume 119 pages 482 7 doi 10.1016 j.jaci.2006.10.007 pmid 17196245 author Caudy AA, Reddy ST, Chatila T, Atkinson JP, Verbsky JB ref or a Severe combined immunodeficiency SCID ref name Bonilla2003 cite journal title 12. Primary immunodeficiency diseases journal J Allergy Clin Immunol year 2003 volume 111 issue 2 Suppl pages S571 81 doi 10.1067 mai.2003.86 pmid 12592303 author Bonilla FA, Geha RS ref . In one patient, deficiency of CD25 on CD4 lymphocytes caused significantly impaired sensitivity to IL 2. This was demonstrated by a lack of measurable response in anti inflammatory interleukin 10 IL 10 secretion to low dose IL 2 incubation. Greatly reduced IL 10 secretion compared to healthy humans results in a syndrome comparable to IPEX syndrome, a type of autoimmunity which is caused by FoxP3 transcription factor dysfunction. In addition to IPEX like symptoms, CD25 deficiency increases susceptibility to viral infections ref name Caudy2007 and possibly fungal and bacterial infections. As IL 2 is an important inducer of lymphocyte Cell proliferation proliferation , the absence of highly sensitive IL 2 receptors may also significantly hinder activation and clonal expansion of CD8 lymphocyte CD8 and ... more details
, suggesting an important role of CD8 sup sup T cells. Street et al. 2001 Perforin is a protein produced by CD8 sup sup T cells, which plays a central role in the Cytotoxin cytotoxic killing mechanisms ... synthesized, and as such are presented on MHC class I molecules to CD8 sup sup T cells ... research is required. Wang, 2003 CD8 sup sup T cells and Antitumour Immunity Historically, much more attention and funding has been devoted to the role of CD8 sup sup T cells in antitumor immunity, rather ... I second, CD8 sup sup T cells, upon being presented with antigen by MHC class I, can directly kill ... immunity, but rather functioned simply in the priming of CD8 sup sup T cells, through activation ... that CD4 sup sup T cells were able to enhance the proliferation and differentiation of CD8 sup sup ... functional MHC class I Hung, 1998 . Subsequent depletion of CD4 sup sup cells and NK cells, but not CD8 ... , while CD8 sup sup mice, could mount a response, weaker than the response of wild type mice ... CD4 sup sup T cells were not present, CD8 sup sup T cells could not mount as effective a response, and thus, the mice died. However, the fact that CD8 sup sup mice were still able to mount some ... only presented by MHC class I molecules, to CD8 sup sup T cells, and not expressed on the cell ... more details
Etiology The postulated cells of origin are a transformed CD8 T cell with clonal rearrangements of chain T cell receptor genes for the majority of cases and a CD8 T cell with clonal rearrangements ... showing a CD4 CD8 T cell subset immunophenotype versus other permutations of those markers. ref ... CD3 dn date September 2011 , TCR dn date September 2011 , CD4 , CD8 style text align center rowspan 3 Rare variants CD3 dn date September 2011 , TCR dn date September 2011 , CD4 , CD8 style text align center CD3 dn date September 2011 , TCR dn date September 2011 , CD4 , CD8 style text align center CD3 dn date September 2011 , TCR dn date September 2011 , CD4 and CD8 variable Genetic ... more details
Image Antigen presentation.svg thumb 240px right Antigen presentation stimulates T cells to become either cytotoxic CD8 cells or helper CD4 cells. seealso Antigen presentation An antigen presenting cell APC or accessory cell is a Cell biology cell that displays foreign antigen complexes with major histocompatibility complex MHC on their surfaces. T cell s may recognize these complexes using their T cell receptor s TCRs . These cells antigen processing process antigens and antigen presentation present them to T cells. Types APCs fall into two categories professional or non professional. T cells cannot recognise, and therefore react to, free antigen. T cells can only see antigen that has been processed and presented by cells via an MHC molecule. Most cells in the body can present antigen to CD8 sup sup T cells via MHC class I molecules and, thus, act as APCs however, the term is often limited to those specialized cells that can prime T cells i.e., activate a T cell that has not been exposed to antigen, termed a naive T cell . These cells, in general, express MHC class II as well as MHC class I molecules, and can stimulate T helper cell CD4 sup sup helper cells as well as Cytotoxic T cell CD8 sup sup cytotoxic T cells , respectively. To help distinguish between the two types of APCs, those that express MHC class II molecules are often called professional antigen presenting cells . Professional APCs Professional APCs are very efficient at internalizing antigen, either by phagocytosis or by receptor mediated endocytosis , and then displaying a fragment of the antigen, bound to a class II Major histocompatibility complex MHC molecule, on their membrane. The T cell recognizes and interacts with the antigen class II MHC molecule complex on the membrane of the antigen presenting cell. An additional co stimulatory signal is then produced by the antigen presenting cell, leading to activation of the T cell. The expression of co stimulatory molecules is a defining feature of pro ... more details
all patients with the activation of cytotoxic T cell CD8 sup sup T cells , which kill HIV infected cells, and subsequently with antibody production, or seroconversion . The CD8 sup sup T cell ... mL . A good CD8 sup sup T cell response has been linked to slower disease progression and a better ... more details
DN , dN , or dn may refer to Dragon Nest , the online game Down disambiguation Dn, abbreviation of Deacon , one of the three major clerical orders in the Christian churches Denmark , a country in northern Europe WMO country code DN Kingfisher Red Air Deccan , an airline based in India IATA code dN, symbol of the Newton unit decinewton , an SI unit of force dn, one of Jacobi s elliptic functions D sub n sub , a Coxeter Dynkin diagram D sub n sub , a Dihedral group Descriptive chess notation Lightweight Directory Access Protocol Distinguished Name , an identifier type in the LDAP protocol Rolling element bearing DN DN the diameter of a rolling element bearing in mm multiplied by its speed in rpm Domain name Name server Domain Nameserver Diametre Nominal, the European equivalent of Nominal Pipe Size . Digha Nikaya , a part of the Buddhist Tripitaka DN, Danish Society for Nature Conservation Danmarks Naturfredningsforening Death Note , a manga anime film series Digital number, the discrete representation of an analog value sampled by an Analog to digital converter Dish Network , a satellite television company Double negative T cell s, also called CD4 sup &minus sup CD8 sup &minus sup Double nil, a bid in the game of Spades Dr. No novel , a James Bond novel made into a film International DN , a kind of iceboat Telephone number Directory number in a phone system The Dreadnought class of warships. Common abbreviation for the city of Dunedin , New Zealand In journalism The Ball State Daily News , the student newspaper of Ball State University in Muncie, Indiana . Dagens N ringsliv , a Norwegian newspaper Dagens Nyheter , a Swedish newspaper Democracy Now , the flagship program for the Pacifica Radio network Di rio de Not cias , a Portuguese newspaper Dos Navigator disambig Category Initialisms cs DN da DN de DN es DN fa DN fr DN ko DN it DN sw DN ja DN no DN andre betydninger pt Di rio de Not cias ro DN sk Dn fi Dn zh DN ... more details
Unreferenced date December 2009 Mergefrom PBMC Mononuclear leukocytes discuss Talk Agranulocyte date February 2010 File Monocyte no vacuoles.JPG thumb 250px Monocyte under a light microscope 40x from a peripheral blood film blood smear surrounded by red blood cell s. Agranulocytes are a category of white blood cell s characterised by the absence of Granule cell biology granule s in their cytoplasm . There are two types of agranulocytes Lymphocyte s Monocyte s. Lymphocytes are much more common in the lymphatic system , and include the so called natural killer T cells . The blood has three types of lymphocytes B cells , T cells and natural killer cells NK cells . B cells make antibodies that bind to pathogens to enable their destruction. CD4 helper T cells co ordinate the immune response they are what becomes defective in an HIV infection . CD8 cytotoxic T cells and natural killer cells are able to kill cells of the body that are infected by a virus. T cells are crucial to the immune response because they possess a unique memory system which allows them to remember past invaders and prevent disease when a similar invader is encountered again. Monocytes share the vacuum cleaner phagocytosis function of neutrophils , but are much longer lived as they have an additional role they present pieces of pathogens to T cells so that the pathogens may be recognized again and killed, or so that an antibody response may be mounted. Monocytes are also known as macrophages after they migrate from the bloodstream and enter tissue. Other white blood cells which are not agranulocytes are mainly the granulocytes neutrophil s, eosinophils and basophil s. Additional images gallery Image Illu blood cell lineage.jpg Blood cell lineage gallery See also white blood cell Blood Category Leukocytes ar cs Agranulocyt es Agranulocito it Agranulocita kk mk nl Agranulocyt ja pl Agranulocyt pt Agranul cito ru sk Agranulocyt sv Agranulocyte ... more details
For the internet slang term PBMC ProblemBetweenMonitorChair mergeto Agranulocyte discuss Talk Agranulocyte date February 2010 A peripheral blood mononuclear cell PBMC is any blood cell biology cell having a round nucleus ref Delves, Peter, et al. Roitt s Essential Immunology, 11th Ed. ISBN 978 1 4051 3603 7 ref . For example a lymphocyte , a monocyte or a macrophage . These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of T cells CD4 and CD8 positive 75 , B cells and NK cells 25 combined . The PBMC population also includes basophils and dendritic cells. These cells can be extracted from whole blood using ficoll , a hydrophilic polysaccharide that separates layers of blood, which will separate the blood into a top layer of plasma, followed by a layer of PBMCs and a bottom fraction of polymorphonuclear cells such as neutrophils and eosinophils and erythrocytes. The polymorphonuclear cells can be further isolated by lysing the red blood cells. PBMCs are widely used in research and clinical uses. See also Peripheral blood cell . Research Applications Many scientists conducting research in the fields of immunology including auto immune disorders , infectious disease , hematological malignancies , vaccine development, Transplant Rejection Transplant Immunology , and high throughput screening are frequent users of Peripheral Blood Mononuclear Cells . In many cases, PBMCs are derived from blood banks . References references DEFAULTSORT Pbmc Category Leukocytes Cell biology stub Immunology stub de PBMC es C lula mononuclear de sangre perif rica ... more details
. CD8 memory T cell number is controlled by a balance between IL 15 and IL 2. When IL 15 binds its receptor ... Cancer IL 15 has been shown to enhance the anti tumor immunity of CD8 T cells in pre clinical ... TA, Restifo NP title IL 15 enhances the in vivo antitumor activity of tumor reactive CD8 T Cells ... BD, Sacks JA, et al. title Interleukin 15 rescues tolerant CD8 T cells for use in adoptive immunotherapy ... more details
Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4 Cd8 Double Positive Thymocytes journal J. Exp. Med. volume 190 issue 2 pages 217 28 year 1999 month ... Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4 Cd8 Double ... more details
Infobox Planet minorplanet yes width 25em bgcolour FFFFC0 apsis name Dallas symbol image caption discovery yes discovery ref discoverer M. Koishikawa discovery site Ayashi Station of the Sendai Astronomical Observatory discovered February 6, 1989 designations yes mp name 8084 alt names 1989 CL1 named after Dallas mp category orbit ref epoch May 14, 2008 aphelion 3.7362317 perihelion 2.3902685 semimajor eccentricity 0.2196953 period 1958.2680033 avg speed inclination 2.14965 asc node 72.40012 mean anomaly 206.91387 arg peri 79.17936 satellites physical characteristics yes dimensions mass density surface grav escape velocity sidereal day axial tilt pole ecliptic lat pole ecliptic lon albedo temperatures temp name1 mean temp 1 max temp 1 temp name2 max temp 2 spectral type abs magnitude 13.2 8084 Dallas 1989 CL1 is a Asteroid belt main belt asteroid discovered on February 6, 1989 by M. Koishikawa at the Ayashi Station of the Sendai Astronomical Observatory . ref cite web url http ssd.jpl.nasa.gov sbdb.cgi?sstr 8084 Dallas JPL title Small Body Database Browser on 8084 Dallas publisher NASA accessdate 2011 09 20 ref References reflist External links MinorPlanets Navigator 8083 Mayeda 8085 1989 CD8 MinorPlanets Footer DEFAULTSORT Dallas Category Main Belt asteroids Category Discoveries by Masahiro Koishikawa Category Asteroids named for places Category Astronomical objects discovered in 1989 beltasteroid stub fa it 8084 Dallas la 8084 Dallas hu 8084 Dallas ja pl 8084 Dallas pt 8084 Dallas uk 8084 vi 8084 Dallas yo 8084 Dallas ... more details
NKG2D is an activating receptor found on Natural killer cell NK cells and Cytotoxic T cell CD8 T cells both and which was first identified in 1991 ref name pmid2007850 cite journal author Houchins, J et al. title DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. journal J. Exp. Med. volume 173 issue pages 1017 1020 year 1991 month pmid 2007850 doi ref and is encoded by the KLRK1 gene. Its function as an activating receptor was first described in 1999 ref name pmid21046993 cite journal author Bauer, S et al. title Activation of NK cells and T cells by NKG2D, a receptor for stress inducible MICA. journal Science volume 285 issue pages 727 729 year 1999 month pmid 21046993 doi 10.1126 science.285.5428.727 ref and its ligands are stressed induced proteins such as MHC class I polypeptide related sequence A MICA , MICB , ULBP1 , ULBP2 , ULBP3 and ULBP4 6 for human NKG2D, and Rae 1 and H 60 for mice NKG2D. ref name pmid18602338 cite journal author Gonz lez, S et al. title NKG2D ligands key targets of the immune response journal Trends in Immunology volume 29 issue 8 pages year 2008 month pmid 18602338 doi 10.1016 j.it.2008.04.007 ref Structure The structure of NKG2D consists of two disulphide linked type II transmembrane proteins with short intracellular proteins uncapable to transduce signals. They therefore require adaptor proteins in order to transduce signals, and this receptor uses two adaptor proteins, DAP10 and DAP12 , which associate as homodimers to the receptor therefore the entire receptor complex appears as a hexamer . ref name pmid21898152 cite journal author Zafirova, B et al. title Regulation of immune cell function and differentiation by the NKG2D receptor journal Cell Mol Life Sci volume 68 issue 21 pages 3519 29 year 2011 month pmid 21898152 doi 10.1007 s00018 011 0797 ... mediated lysis. The function of NKG2D on CD8 T cells is to send co stimulatory signals to activate ... more details
B , IFN , and CXCR3 mRNA in peripheral natural killer cell NK cell s and CD8 sup sup T cell s. This suggested that IL 21 enhances the CD8 sup sup effector functions thus leading to anti tumor response ... with impaired IL 21 signaling had more dramatic exhaustion of LCMV specific Cytotoxic T cell CD8 T cell s, suggesting that IL 21 produced by T helper cell CD4 T cells is required for sustained CD8 ... effects of IL 21 and IL 15 on perforin expression, lysosomal degranulation, and proliferation in CD8 ... Contribute to Durable Viral Control through the Modulation of HIV Specific CD8 T Cell Function ... name chevalier et al In addition, IL 21 producing virus specific CD8 T cells were also preferentially ... 1 specific CD8 T cells are Preferentially Seen in Elite Controllers journal Journal of Virology volume ... These data and the fact that IL 21 stimulated CD8 or NK cells are able to inhibit HIV viral replication ... more details
and CD1a . The immunophenotype CD4 CD8 is present in 60 of cases, the CD4 CD8 immunophenotype is present in 25 , and the CD4 CD8 immunophenotype is present in 15 of cases. ref name mat1 Genetic findings ... more details
G1 on antigen specific human CD8 T lymphocytes during active, latent, and resolved infection ... N, et al. title Analysis of CD127 and KLRG1 expression on hepatitis C virus specific CD8 T cells ... more details
For the 2001 single box, see Mehr davon Die Single Box 1995 2000 Infobox album Name Mehr davon Die Single Box Type box Artist Die Toten Hosen Cover Mehrdavon05.jpg Recorded 1995 2004 Released 2005 Length Genre Punk rock Label JKP Producer Last album Nur zu Besuch Unplugged im Wiener Burgtheater br 2005 This album Mehr davon Die Single Box br 2005 Next album In aller Stille br 2008 Mehr davon Die Single Box More of it is a single box by the Germany German punk rock punk band Die Toten Hosen . It contains some of the more important singles from 1995 2004 , 1996 2005 or 1995 2002 , depending on the version. The 2001 release Mehr davon Die Single Box 1995 2000 partly crosses over with this release and also has different variations. Variations 1995 2004 CD1 Nichts bleibt f r die Ewigkeit 1995 Nichts bleibt f r die Ewigkeit br CD2 Zehn kleine J germeister 1996 Zehn kleine J germeister br CD3 Unsterblich 2000 Unsterblich br CD4 Bayern 2000 Bayern br CD5 Was z hlt 2001 Was z hlt br CD6 Kein Alkohol ist auch keine L sung 2002 Kein Alkohol ist auch keine L sung br CD7 Frauen dieser Welt 2002 Frauen dieser Welt br CD8 Ich bin die Sehnsucht in dir 2004 Ich bin die Sehnsucht in dir 1996 2005 CD1 Zehn kleine J germeister 1996 Zehn kleine J germeister br CD2 Unsterblich 2000 Unsterblich br CD3 Bayern 2000 Bayern br CD4 Was z hlt 2001 Was z hlt br CD5 Kein Alkohol ist auch keine L sung 2002 Kein Alkohol ist auch keine L sung br CD6 Frauen dieser Welt 2002 Frauen dieser Welt br CD7 Ich bin die Sehnsucht in dir 2004 Ich bin die Sehnsucht in dir br CD8 Alles wird vor bergehen 2005 Alles wird vor bergehen 1995 2002 CD1 Nichts bleibt f r die Ewigkeit 1995 Nichts bleibt f r die Ewigkeit br CD2 Paradies 1996 Paradies br CD3 Zehn kleine J germeister 1996 Zehn kleine J germeister br CD4 Alles aus Liebe live 1997 Alles aus Liebe live br CD5 Sch n sein 1999 Sch n sein br CD6 Unsterblich 2000 Unsterblich br CD7 Warum werde ich nicht satt? 2000 Warum werde ich nicht satt? br CD8 Kein Alkohol is ... more details
CD8 cells or helper CD4 cells. Intracellular antigens are produced mainly by viruses replicating ... surface. MHC Class I molecules present antigen to CD8 cytotoxic T cell s. With the exception of some ... more details
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