also List of JWH cannabinoids HU 210 Other HU Cannabinoids List of HU cannabinoids CP 47,497 See also List of CP cannabinoids Further reading A more complete list can be found here http www.surechem.org ... References references Category AM cannabinoids Category Cannabinoids ... more details
of 5.44nM at CB sub 2 sub and 20.9nM at CB sub 1 sub . See also List of AM cannabinoids HU 210 Other HU Cannabinoids List of HU cannabinoids CP 47,497 See also List of CP cannabinoids References references Category JWH cannabinoids Category Cannabinoids ... more details
CBND may refer to Cannabinodiol, a cannabinoid see Cannabinoids Table of natural cannabinoids . Compagnie B ninoise de N goce et de Distribution , a retail and trading company in Benin. disambig ... more details
AM 251 may refer to USS Inflict AM 251 AM251 a Cannabinoid receptor type 1 CB1 Cannabinoids cannabinoid receptor antagonist Letter NumberCombDisambig ... more details
Drugbox verifiedrevid 354916523 IUPAC name 6a R ,10a R 6,6,9 trimethyl 3 butyl 6a,7,8,10a tetrahydro 6 H benzo c chromen 1 ol image Delta 9 tetrahydrocannabinol C4.png drug name sup 9 sup Tetrahydrocannabinol C4 Clinical data tradename pregnancy category legal status ? routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number ATC prefix none ATC suffix PubChem Chemical data C 20 H 28 O 2 molecular weight 300.43 g mol smiles Tetrahydrocannabinol C4 , also known as THC C4 and butyl THC , is a homolog chemistry homologue of tetrahydrocannabinol THC , the active component of Cannabis drug Cannabis . They are only different by the pentyl sidechain being replaced by a butyl sidechain. It is unknown whether THC C4 is an agonist , partial agonist , or receptor antagonist antagonist at the cannabinoid receptor s. The propyl anolog, THCV is a known antagonist while THC itself is an agonist. See also Cannabinoids Cannabis Cannabinoids cannabinoid stub Category Phenols Category Cannabinoids Category Diterpenes Category Benzochromenes ... more details
CB1 may refer to CB1 Cheese Burger 1r Oner Famous Graffiti Artist in Cudahy who graffed the streets from early 2005 present CB1, a postcode district in the CB postcode area Cannabinoid receptor 1 a receptor for cannabinoids in the brain Crash Bandicoot video game Crash Bandicoot , the first game in the Crash Bandicoot series Letter NumberCombDisambig ... more details
Drugbox verifiedrevid 435602295 IUPAC name 6aR,10aR 6a,7,10,10a Tetrahydro 3 5 1H imidazol 1 yl 1,1 dimethylpentyl 6,6,9 trimethyl 6H dibenzo b,d pyran 1 ol image O 2545.svg width 240 Clinical data tradename legal status Unscheduled routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number 874745 42 3 PubChem Chemical data C 26 H 36 N 2 O 2 molecular weight 408.575 g mol smiles CC C CCCCn1ccnc1 c3cc2OC C C C H 4C C C C C C H 4c2c O c3 O 2545 is an analgesic cannabinoid derivative created by Organix Inc. for use in scientific research. Unlike most cannabinoids discovered to date, it is water soluble, which gives it considerable advantages over many related cannabinoids. It has high affinity for both cannabinoid receptor 1 CB sub 1 sub and cannabinoid receptor 2 CB sub 2 sub Receptor biochemistry receptors , with Dissociation constant Ki values of 1.5nM at CB sub 1 sub and 0.32nM at CB sub 2 sub . ref Martin BR, Wiley JL, Beletskaya I, Sim Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK. Pharmacological characterization of novel water soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics . 2006 Sep 318 3 1230 9. PMID 16757541 ref See also O 2113 O 2372 Tropoxane References references cannabinoids cannabinoid stub Category Cannabinoids Category Benzochromenes Category Phenols Category Imidazoles ... more details
, most potent cannabis product I ve ever tested. Marijuana contains various cannabinoids, Hornby explains ... had an ounce of it, only a tiny fraction of a gram would be anything other than cannabinoids. We also ... none. It s essentially just pure cannabinoids. I ve tested a lot of cannabis materials, but this is the most impressive. Hornby s tests also found Budder contains 80 to 90 of its cannabinoids as THC. It contains much smaller percentages of two other cannabinoids cannabidiol and cannabinol. Of these two ... more details
novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988 247 1046 1051 ... of cannabinoids. ref Tramer MR, Carroll D, Campbell FA, Reynolds DJ, Moore RA, McQuay HJ. Cannabinoids for control of chemotherapy induced nausea and vomiting quantitative systematic review ... DJ, Moore RA, McQuay HJ. Are cannabinoids an effective and safe treatment option in the management ... ref Ben Amar M. Cannabinoids in medicine A review of their therapeutic potential. Journal of Ethnopharmacology . 2006 Apr 21 105 1 2 1 25. ref See also CP 47,497 References references Cannabinoids pharma stub cannabinoid stub Category Cannabinoids Category Phenanthridines Category Phenol ethers Category ... more details
Drugbox verifiedrevid 427504107 IUPAC name 2 Isopropyl 5 methyl 1 2,6 dihydroxy 4 nonylphenyl cyclohex 1 ene image IPMDHNPC.png width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem Chemical data C 25 H 40 O 2 molecular weight 372.582 g mol smiles CC C C 2CCC C CC 2c1c O cc cc1O CCCCCCCCC 2 Isopropyl 5 methyl 1 2,6 dihydroxy 4 nonylphenyl cyclohex 1 ene is an analgesic compound which is a cannabinoid agonist . It is a ring opened cannabinoid derivative, an analogue of cannabidiol . However, unlike cannabidiol, this compound produces potent cannabis like effects in animals, suggesting it acts as a cannabinoid receptor 1 CB sub 1 sub agonist. ref cite book chapter The Total Synthesis of Cannabinoids title The Total Synthesis of Natural Products publisher Wiley Interscience author Razdan, K. editor John Apsimon year 1981 page 245 isbn 978 0 471 05460 3 oclc 19487018 ref It can be synthesized by Birch reduction from the nonyl analog of cannabidiol . ref cite journal author Razdan RK, Pars HG, Thompson WR, Granchelli FE journal Tetrahedron Letters year 1974 pages 4315 doi 10.1016 S0040 4039 01 92152 5 title Lithium ammonia reduction of tetrahydrocannabinols volume 15 issue 49 50 ref References references cannabinoids DEFAULTSORT Isopropyl 5 methyl 1 2,6 dihydroxy 4 nonylphenyl cyclohex 1 ene, 2 Category Cannabinoids Category Resorcinols cannabinoid stub ... more details
Drugbox verifiedrevid 446204559 IUPAC name 6aR,10aR 1 methoxy 6,6,9 trimethyl 3 2R 1,1,2 trimethylbutyl 6a,7,10,10a tetrahydrobenzo c chromene image JWH 359 structure.png width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem DrugBank Ref drugbankcite correct drugbank Chemical data C 24 H 36 O 2 molecular weight 356.540 g mol smiles COc2cc C C C C C CC cc3c2C1CC C CCC1C C C O3 JWH 359 is a dibenzopyran classical cannabinoid drug, which is a potent and selective Cannabinoid receptor type 2 CB sub 2 sub receptor agonist, with a Dissociation constant K sub i sub of 13.0nM and selectivity of around 220x for CB sub 2 sub over Cannabinoid receptor type 1 CB sub 1 sub receptors. It is related to other dibenzopyran CB sub 2 sub agonists such as JWH 133 and L 759,656 but with a Chiral chemistry chiral side chain which has made it useful in mapping the shape of the Cannabinoid receptor type 2 CB sub 2 sub binding site. ref Cite pmid 16165365 ref ref cite journal pmid 18289088 doi 10.2174 156802608783498014 ref It was discovered by, and named after, Dr. John W. Huffman . References references Cannabinoids Category Cannabinoids Category JWH cannabinoids Category Benzochromenes Category Phenol ethers cannabinoid stub ... more details
Drugbox verifiedrevid 413559074 IUPAC name 4aR,13bR 2,5,5 trimethyl 8 pentyl 3,4,4a,5,8,13b hexahydroisochromeno 3,4 b carbazol 13 ol image JWH 161 structure.png width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem 10431286 Chemical data C 27 H 33 N 1 O 2 molecular weight 403.555 g mol smiles c5cccc1c5c2c O c c OC3 C C cc2n1CCCCC C4C3CCC C C4 JWH 161 is a cannabinoid derivative that was designed by Dr John W. Huffman s team as a hybrid between the dibenzopyran classical cannabinoid drugs and the novel indole derivatives, in an attempt to unravel the differences in their binding modes to the CB sub 1 sub receptor. While retaining structural elements from both families, JWH 161 has a Cannabinoid receptor type 1 CB sub 1 sub Dissociation constant Protein ligand binding K sub i sub of 19.0nM, although it was found to be slightly weaker than tetrahydrocannabinol THC in animal tests. ref name pmid15974991 cite journal author Huffman JW, Padgett LW title Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes journal Current Medicinal Chemistry volume 12 issue 12 pages 1395 411 year 2005 pmid 15974991 doi 10.2174 0929867054020864 url ref References references Cannabinoids Category Cannabinoids Category JWH cannabinoids Category Phenol ethers cannabinoid stub ... more details
JWH may refer to John Wesley Hardin , an American gun fighter from the 18th century John W. Henry , futures trader and owner of the Boston Red Sox John Howard John Winston Howard , former Prime Minister of Australia JWH 133 , a medication used to prevent Alzheimer s disease John W. Huffman , creator of the JWH cannabinoids Jared Waerea Hargreaves New Zealand rugby league player for the Manly Sea Eagles disambig it JWH ... more details
Drugbox verifiedrevid 437389159 IUPAC name 3 5 cyano 1 ,1 dimethylpentyl 1 4 N morpholinobutyryloxy 8 tetrahydrocannabinol image O 1057 molecular geometry.svg width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number PubChem Chemical data C 32 H 46 N 2 O 4 molecular weight 522.717 g mol smiles N CCCCCC c3cc1OC C H 4C C C CC4c1c OC O CCCN2CCOCC2 c3 C C C C C O 1057 is an analgesic cannabinoid derivative created by Organix Inc. for use in scientific research. Unlike most cannabinoids discovered to date, it is water soluble, which gives it considerable advantages over many related cannabinoids. It has moderate affinity for both cannabinoid receptor 1 CB sub 1 sub and cannabinoid receptor 2 CB sub 2 sub Receptor biochemistry receptors , with Dissociation constant K sub i sub values of 8.36nM at CB sub 1 sub and 7.95nM at CB sub 2 sub . ref Pertwee RG, Gibson TM, Stevenson LA, Ross RA, Banner WK, Saha B, Razdan RK, Martin BR. O 1057, a potent water soluble cannabinoid receptor agonist with antinociceptive properties. British Journal of Pharmacology . 2000 Apr 129 8 1577 84. PMID 10780961 ref See also AM 2232 O 774 O 1812 O 2694 References references cannabinoids cannabinoid stub Category Cannabinoids Category Benzochromenes Category Butyrates Category Morpholines Category Nitriles ... more details
Drugbox Watchedfields changed verifiedrevid 437691572 IUPAC name 1 1E 3 pentylinden 1 ylidine methyl naphthalene image JWH 171.png width 180 Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status Legal routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number ATC prefix ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data C 25 H 24 molecular weight 324.457 g mol smiles CCCCCc c3 c1ccccc1c3 Cc2cccc4ccccc24 JWH 176 is an analgesic drug which acts as a cannabinoid receptor agonist . Its Dissociation constant Protein ligand binding binding affinity at the CB sub 1 sub receptor is only 26.0nM, making it more potent than THC itself, ref Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry , 2005 12 1395 1411. ref however JWH 176 is particularly notable in that it is a hydrocarbon containing no heteroatom s. This demonstrates that reasonably high affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals force Van der Waals interactions to bind to the receptor. ref Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3 540 22565 X ref It was discovered by, and named after, Dr. John W. Huffman . See also JWH 175 References references Cannabinoids cannabinoid stub Category Cannabinoids Category JWH cannabinoids Category Naphthalenes Category Indenes Category Polycyclic aromatic hydrocarbons ... more details
Drugbox verifiedrevid 435604466 IUPAC name 6aR,10aR 6,6,9 trimethyl 3 2 methyl 7 morpholin 4 yl 7 oxoheptan 2 yl 6a,7,10,10a tetrahydrobenzo c chromen 1 yl 4 di propan 2 yl amino butanoate image O 2694.png width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number PubChem 11714280 Chemical data C 38 H 60 N 2 O 5 molecular weight 624.891 g mol smiles CC C N C C C CCCC O Oc c1C2CC 3C cc C C C CCCCC O N4CCOCC4 cc1OC C C C2CC 3 O 2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water soluble, which gives it considerable advantages over many related drugs. It has high affinity for both cannabinoid receptor 1 CB sub 1 sub and cannabinoid receptor 2 CB sub 2 sub Receptor biochemistry receptors , with Dissociation constant Ki values of 3.7nM at CB sub 1 sub and 2.8nM at CB sub 2 sub . However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water insoluble compound O 2372 , thus producing a biphasic effects profile that is less suitable for research purposes than the related compound O 2545 . ref Martin BR, Wiley JL, Beletskaya I, Sim Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK. Pharmacological characterization of novel water soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics . 2006 Sep 318 3 1230 9. PMID 16757541 ref See also O 1057 O 2372 References references cannabinoids cannabinoid stub Category Cannabinoids Category Benzochromenes Category Butyrates Category Morpholines Category Amides ... more details
In 1975, Munson discovered that cannabinoids suppress Lewis lung carcinoma cell growth. The mechanism of this action was shown to be inhibition of DNA synthesis ref cite journal pmid 616322 year 1977 title In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas. journal Cancer Biochem Biophys. ref Cannabinoids increase the life span of mice carrying Lewis lung tumors and decrease primary tumor size. ref cite journal pmid 16250836 year 2005 title Cannabinoids and cancer. journal Mini Rev Med Chem. doi 10.2174 138955705774329555 ref There are multiple modes of action. ref cite journal pmid 12958205 year 2003 title Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading actions on signals involved in angiogenesis and metastasis. journal FASEB J ref A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. ref Cancer Chemother Rep 2 1972 Nov 3 1 325 ref It is also called 3LL and LLC and is used as a transplantable malignancy. It has been used in many studies. ref name TeicherAndrews2004 cite book last1 Teicher first1 Beverly A. last2 Andrews first2 Paul A. title Anticancer drug development guide preclinical screening, clinical trials, and approval url http books.google.com books?id k4jWvlQ2CCcC&pg PA197 accessdate 31 July 2011 year 2004 publisher Humana Press isbn 9781588292285 pages 197 ref References reflist Category Cancer research Medical stub ... more details
Drugbox Watchedfields changed verifiedrevid 444611944 IUPAC name 6,6,9 trimethyl 3 3 methyloctan 2 yl 7,8,9,10 tetrahydrobenzo c chromen 1 yl 4 azepan 1 yl butanoate image Nabazenil structure.png width 200 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 58019 65 1 PubChem 163326 DrugBank Ref drugbankcite correct drugbank UNII Ref fdacite correct FDA UNII N1RX70K36C Chemical data C 35 H 55 N 1 O 3 molecular weight 537.814 g mol smiles CCCCCC C C C C1 CC2 C C3 C CCC C3 C C O2 C C C C1 OC O CCCN4CCCCCC4 Nabazenil SP 175 is a synthetic cannabinoid receptor agonist , which has anticonvulsant properties. ref Concise dictionary of pharmacological agents properties and synonyms. p188. ISBN 0751404993 ref References reflist cannabinoids Category Cannabinoids Category Benzochromenes Category Azepanes Category Butyrates ... more details
Drugbox Watchedfields changed verifiedrevid 445419224 IUPAC name 6,6,9 trimethyl 3 nonan 2 yl 7,8,9,10 tetrahydrobenzo c chromen 1 yl 4 diethylamino butanoate image Naboctate structure.png width 200 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 74912 19 9 PubChem 3033579 DrugBank Ref drugbankcite correct drugbank UNII Ref fdacite correct FDA UNII N6YFU80HRG Chemical data C 33 H 53 N 1 O 3 molecular weight 511.777 g mol smiles CCCCCCCC C C1 CC2 C C3 C CCC C3 C C O2 C C C C1 OC O CCCN CC CC Naboctate SP 325 is a synthetic cannabinoid receptor agonist , which has antiemetic , sedative , anxiolytic and anti glaucoma properties. ref Concise dictionary of pharmacological agents properties and synonyms. p188. ISBN 0751404993 ref References reflist cannabinoids Category Cannabinoids Category Benzochromenes Category Butyrates Category Amines ... more details
Drugbox Watchedfields changed verifiedrevid 444058373 IUPAC name 3,6,6,9 tetramethyl 7,8,9,10 tetrahydrobenzo c chromen 1 yl acetate image Pirnabine structure.png width 200 Clinical data tradename legal status routes of administration Pharmacokinetic data metabolism elimination half life excretion Identifiers CAS number 68298 00 0 PubChem 50137 DrugBank Ref drugbankcite correct drugbank UNII Ref fdacite correct FDA UNII S3FHL03F60 Chemical data C 19 H 24 O 3 molecular weight 300.391 g mol smiles O C C Oc1cc C cc OC2 C C c1C C3 C2CCC3C Pirnabine SP 304 is a synthetic cannabinoid receptor ligand, which was developed for the treatment of glaucoma . ref http jama.ama assn.org cgi reprint 241 1 65.pdf ref References reflist cannabinoids Category Cannabinoids Category Benzochromenes Category Phenols Category Acetate esters ... more details
by 8 and 9 tetrahydrocannabivarin in mice in vivo. Br. J. Pharmacol. 150 5 586 94. ref See also Cannabinoids ... sativa http www.tetrahydrocannabivarin.com www.tetrahydrocannabivarin.com Article on THCV Cannabinoids Category Cannabinoids Category CB1 receptor antagonists Category Benzochromenes Category ... more details
of Alzheimer s Disease Pathology by Cannabinoids Neuroprotection Mediated by Blockade of Microglial Activation Cannabinoids Category Cannabinoids Category JWH cannabinoids Category Benzochromenes ... more details
or sedative , ref Archer RA. The cannabinoids therapeutic potentials. Annual Reports in Medicinal ... it is sometimes used in research into the potential therapeutic applications of cannabinoids. References references Cannabinoids Category Cannabinoids Category Synthetic chromenes Category Alkynes ... more details
Encyclopedia
top
