Orphan date February 2009 PBB geneid 80124 Deubiquitinating protein VCIP135 is a protein that in humans is encoded by the VCPIP1 gene . ref name pmid11347906 cite journal author Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O title Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro journal DNA Res volume 8 issue 2 pages 85 95 year 2001 month May pmid 11347906 pmc doi 10.1093 dnares 8.2.85 ref ref name pmid12509440 cite journal author Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE title Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase anchoring protein 3 and valosin containing protein p97 during capacitation journal J Biol Chem volume 278 issue 13 pages 11579 89 year 2003 month Mar pmid 12509440 pmc doi 10.1074 jbc.M202325200 ref ref name entrez cite web title Entrez Gene VCPIP1 valosin containing protein p97 p47 complex interacting protein 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 80124 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Maruyama K, Sugano S title Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. journal Gene volume 138 issue 1 2 pages 171 4 year 1994 pmid 8125298 doi 10.1016 0378 1119 94 90802 8 cite journal author Bonaldo MF, Lennon G, Soares MB title Normalization and subtraction two approaches to facilitate gene discovery journal Genome Res. volume 6 issue 9 pages 791 806 year 1997 pmid 8889548 doi 10.1101 gr.6.9.791 cite journal author Suzuki Y, Yoshitomo Nakagawa K, Maruyama K, et al. title Constru ... more details
The Centre for Human Reproductive Science ChRS was established in December 2006 to further develop research and innovation in fertility diagnosis and treatment, working in partnership as the academic and research wing of the Birmingham Women s Fertility Centre at Birmingham Women s Hospital . A particular emphasis in the biomedical research strategy is placing research and discovery in the true physiological context. ref name pmid16354709 cite journal author Barratt CL, Kirkman Brown J title Man made versus female made environment will the real capacitation please stand up? journal Human Reproduction Update volume 12 issue 1 pages 1 2 year 2006 pmid 16354709 doi 10.1093 humupd dmi051 month Jan issn 1355 4786 ref Research Advances The ChRS team alongside the Fertility Centre have made recent notable advances in various areas, these include achievements in Translational medicine, such as the invention of the male Fertell over the counter home fertility test. ref name pmid16267078 cite journal author Bj rndahl L, Kirkman Brown J, Hart G, Rattle S, Barratt CL title Development of a novel home sperm test journal Human Reproduction volume 21 issue 1 pages 145 9 year 2006 month January pmid 16267078 doi 10.1093 humrep dei330 issn 0268 1161 url http humrep.oxfordjournals.org cgi pmidlookup?view long&pmid 16267078 format Free full text ref The first detailed studies of ion channels in human sperm. ref name pmid15385161 cite journal author Gu Y, Kirkman Brown JC, Korchev Y, Barratt CL, Publicover SJ title Multi state, 4 aminopyridine sensitive ion channels in human spermatozoa journal Developmental Biology volume 274 issue 2 pages 308 17 year 2004 month October pmid 15385161 doi 10.1016 j.ydbio.2004.06.025 issn 0012 1606 ref ref name pmid17516540 cite journal author Jim nez Gonz lez MC, Gu Y, Kirkman Brown J, Barratt CL, Publicover S title Patch clamp mapping of ion channel activity in human sperm reveals regionalisation and co localisation into mixed clusters journal Journal ... more details
PBB geneid 55811 Adenylate cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene . ref name pmid10566627 cite journal author Reed BY, Heller HJ, Gitomer WL, Pak CY title Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3 q24 journal J. Clin. Endocrinol. Metab. volume 84 issue 11 pages 3907 13 year 1999 month November pmid 10566627 doi 10.1210 jc.84.11.3907 url ref Function The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of Cyclic adenosine monophosphate cAMP in spermatozoa , implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and or the acrosome reaction. ref name entrez cite web title Entrez Gene ADCY10 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 55811 accessdate ref Clinical significance Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria . ref name pmid10566627 References Reflist Further reading refbegin 2 PBB Further reading citations cite journal author Wuttke MS, Buck J, Levin LR title Bicarbonate regulated soluble adenylyl cyclase. journal JOP volume 2 issue 4 Suppl pages 154 8 year 2002 pmid 11875252 doi cite journal author Hukovic N, Panetta R, Kumar U, et al. title The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization. journal J. Biol. Chem. volume 273 issue 33 pages 21416 22 year 1998 pmid 9694905 doi 10.1074 jbc.273.33.21416 cite journal author Buck J, Sinclair ML, Schapal L, et al. title Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals journal Proc. Natl. Acad. S ... more details
3 phosphate dehydrogenase 2 in mouse sperm capacitation journal Molecular Reproduction and Development ... phosphoproteome of hamster spermatozoa Role of glycerol 3 phosphate dehydrogenase 2 in sperm capacitation ... more details
File D.melanogaster Female Sperm Storage.jpg thumb Sperm storage organs in the fruit fly Drosophila melanogaster . Female was first mated with GFP male and then re mated with RFP male. Female sperm storage is a biological process in which spermatozoa sperm cells transferred to a female during mating are temporarily retained within a specific part of the reproductive tract before the oocyte , or egg, is fertilized. The site of storage is variable among different animal taxa and ranges from structures that appear to function solely for sperm retention, such as insect spermatheca ref Klowden MJ. 2003. Spermatheca. In Resh VH and Card RT eds. Encyclopedia of Insects. San Diego, CA Academic Press. 1266. ref and bird sperm storage tubules bird anatomy , ref Liem KL, Bemis WE, Walker WF & Grande L. 2001. Functional Anatomy of the Vertebrates, an Evolutionary Perspective 3rd ed. Belmont, CA Brooks Cole Thomson Learning. Pp703. ref ref Birkhead TR. 1998. Sperm Competition in Birds mechanisms and function. In Birkhead TR & M ller AP eds. 1998. Sperm Competition and Sexual Selection. San Diego, CA Academic Press. Pp. 826. ref to more general regions of the reproductive tract enriched with receptors to which sperm associate before fertilization, such as the caudal portion of the cow oviduct containing sperm associating annexin s. ref Ignotz GG, Cho MY & Suarez SS. 2007. Annexins are candidate oviductal receptors for bovine sperm surface proteins and thus may serve to hold bovine sperm in the oviductal reservoir. Biology of Reproduction 77 906 913. ref Female sperm storage is an integral stage in the reproductive process for many animals with internal fertilization. It has several documented biological functions including Supporting the sperm by a. enabling sperm to undergo biochemical transitions, called capacitation and motility hyperactivation , in which they become physiologically capable of fertilizing an oocyte e.g. mammals ref name sss02 Suarez SS. 2002. Formation of a r ... more details
which most likely inhibits premature capacitation . The accessory genital ducts ... Health and fitness Medicine Sexuality Capacitation Cum shot Milt Semen extender Spawn biology Spawn ... more details
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