isobacteriochlorin CHEBI 52583 accessdate 1 February 2012 ref File Porphyrin, chlorin, bacteriochlorins.png 540px thumb left Structures comparing porphin , chlorin, bacteriochlorin, and isobacteriochlorin ... therapy . Chlorin is not to be confused with the chemical element chlorine . References references ... Category Photosynthesis Category Tetrapyrroles de Chlorin fr Chlorine io Klorino id Klorin heterolingkar ... more details
and e are chlorin s, meaning their molecules have a chlorin macrocycle ring with one reduced pyrrole ring D . File Porphyrin, chlorin, bacteriochlorins.png 540px thumb center Chemical structure s comparing porphin , chlorin , bacteriochlorin , and isobacteriochlorin . Note relocation of C C double ... more details
Unreferenced stub auto yes date December 2009 Tetrapyrroles are compounds containing four pyrrole rings. With the exception of corrin , the four pyrrole rings are interconnected through one carbon methine or methylene bridges, in either a linear or a cyclic fashion. Because of their ability to form metal complexes, these compounds are particularly important in biological systems. Linear tetrapyrroles bilane s , using three one carbon bridges, include Heme breakdown products e.g., bilirubin Phycobilin s found in cyanobacteria Cyclic tetrapyrroles, using four one carbon bridges, include Porphyrin s e.g., heme Chlorin s e.g., chlorophyll a Chlorophyll a Corrin s are cyclic tetrapyrroles that have replaced one of the conventional methine bridges with a direct interpyrrole bond. External links http www.chem.qmul.ac.uk iupac tetrapyrrole app1.html Tetrapyrroles Category Tetrapyrroles Biochem stub ca Tetrapirrol de Tetrapyrrole es Tetrapirrol gl Tetrapirrol nl Tetrapyrrool ja sv Tetrapyrrol ug zh ... more details
. File Chlorin.svg thumb right This is the structure of a chlorin ring without the central Mg ... a consists of a N ring with a Mg center, side chains , and a hydrocarbon hydrocarbon tail . Chlorin ... as a chlorinchlorin ring . The chlorin ring is a heterocyclic compound derived from a pyrrole that encases ... more details
Drugbox verifiedrevid 447519392 IUPAC name N 2 S ,3 S 7 carboxy 3 2 carboxyethyl 12 ethyl 2,8,13,18 tetramethyl 17 vinyl 2,3 dihydroporphyrin 5 yl acetyl small L small aspartic acid image Talaporfin.png Clinical data tradename Drugs.com drugs.com international talaporfin pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status Rx only routes of administration Intravenous therapy IV Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 110230 98 3 CAS supplemental br CAS 220201 34 3 sodium salt ATC prefix none ATC suffix ATC supplemental PubChem 5486799 DrugBank Ref drugbankcite correct drugbank DrugBank UNII Ref fdacite correct FDA UNII P4ROX5ELT2 Chemical data chemical formula C 38 H 41 N 5 O 9 molecular weight 711.76 g mol smiles CCC1 C2C C3C C C N3 C C4 C H C H C N4 C C5C C C CC C1C N2 N5 C C C C CCC O O CC O N C H CC O O C O O C O O C Talaporfin International Nonproprietary Name INN , also known as aspartyl chlorin , mono L aspartyl chlorine e6, NPe6 , or LS11 is a photosensitizer used in photodynamic therapy PDT . It absorbs red light at 664nm normally provided by a laser tuned to this wavelength. ref http journals.lww.com jto Fulltext 2006 06000 Photodynamic Therapy PDT for Lung Cancers.18.aspx Photodynamic Therapy PDT for Lung Cancers 2006 ref It was approved in Japan in 2004 for Photodynamic therapy PDT of lung cancer and marketed as Laserphyrin . ref http meeting.ascopubs.org cgi content abstract 24 18 suppl 7229 Photodynamic therapy using Laserphyrin for centrally located early stage lung cancer 2006 ref It is trademarked as Aptocine by Light Sciences Oncology. ref http www.lsoncology.com aptocine ref References reflist Chemotherapeutic agents Category Photosensitizing agen ... more details
A macrocycle is, as defined by IUPAC , a cyclic macromolecule or a macromolecular cyclic portion of a molecule. ref iupac 01 In the chemical literature, organic chemists may consider any molecule containing a ring of nine or more atoms to be a macrocycle. Citation needed reason Jan 2010 date January 2010 Coordination chemists generally define a macrocycle more narrowly as a cyclic molecule with three or more potential donor atoms that can coordinate to a metal center. Macrocycle effect File Cyclen Zinc InorgChem 1997 4579 commons.jpg thumbnail 175px Crystal structure of a Zn II ion coordinated to cyclen and ethanol reported in Inorg. Chem., 1997, 4579 4584. The macrocyclic effect was discovered in 1969. ref Cabbiness 01 Coordination chemists study macrocycles with three or more potential donor atoms in rings of greater than nine atoms as these compounds often have strong and specific binding with metals. ref melson 01 This property of coordinating macrocyclic molecules is the macrocycle effect. Synthesis Macrocycles are generally synthesized from smaller, usually linear, molecules. Historical uses Macrocycles have been in use for several decades as synthetic dyes. Phthalocyanine is a porphyrin analogue, which is arguably the most useful, in uses as dyes and pigments since their discovery in 1928, due to their dark blue colour. There are however many other uses for them. Their name comes from their synthetic precursor, phthalodinitrile. ref milgrom 01 Biological macrocycles Heme , the active site in the hemoglobin the protein in blood that transports oxygen is a porphyrin containing iron. Chlorophyll , the green photosynthetic pigment found in plants contains a chlorin ring. Vitamin B12 , contains a corrin ring. Related molecular categories Ligand an atom, ion or functional group that is bonded to one or more central atoms or ions. Chelate a multidentate ligand, containing more than one donor atom. Cryptand a macrocycle with multiple loops e.g. bicyclic . Rotaxane ma ... more details
hemoproteins. Several other heterocycles are related to porphyrins. These include corrin s, chlorin s, bacteriochlorophyll s, and Cofactor F430 corphins . Chlorin s 2,3 dihydroporphyrin are more ... more details
metal complexes often have strong colors. A similar molecular structural ring unit called chlorin ... small Heme group of hemoglobin small small The chlorin section of the chlorophyll a molecule. The green ... more details
plays a crucial role in photosynthesis . It contains a magnesium enclosed in a chlorin ring ... by other divalent ions with little loss of activity. Rather, the photon is absorbed by the chlorin ... more details
, and mono L aspartyl chlorin e6 NPe6 . Several photosensitizers are commercially available for clinical ... chlorin in the nuclear envelope journal Photochemistry and Photobiology volume 81 issue 6 pages 1544 ... more details
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