PBB geneid 57107 Decaprenyl diphosphate synthase subunit 2 PDSS2 , also known as candidate tumor suppressor protein , is a protein that in humans is encoded by the PDSS2 gene . ref name entrez cite web title Entrez Gene prenyl decaprenyl diphosphate synthase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 57107 accessdate ref Function The protein encoded by this gene is an enzyme that synthesizes the prenyl side chain of coenzyme Q, or Coenzyme Q10 ubiquinone , one of the key elements in the electron transport chain respiratory chain . The gene product catalyzes the formation of all trans polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. ref name entrez Clinical significance It may be associated with Coenzyme Q10 deficiency . ref OMIM 607426 ref See also PDSS1 References reflist Further reading refbegin 2 cite journal author Talmud PJ, Drenos F, Shah S, et al. title Gene centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. journal Am. J. Hum. Genet. volume 85 issue 5 pages 628 42 year 2009 pmid 19913121 doi 10.1016 j.ajhg.2009.10.014 pmc 2775832 cite journal author Mungall AJ, Palmer SA, Sims SK, et al. title The DNA sequence and analysis of human chromosome 6. journal Nature volume 425 issue 6960 pages 805 11 year 2003 pmid 14574404 doi 10.1038 nature02055 cite journal author Diomedi Camassei F, Di Giandomenico S, Santorelli FM, et al. title COQ2 nephropathy a newly described inherited mitochondriopathy with primary renal involvement. journal J. Am. Soc. Nephrol. volume 18 issue 10 pages 2773 80 year 2007 pmid 17855635 doi 10.1681 ASN.2006080833 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi ... more details
F420 may refer to Coenzyme F420 , a coenzyme involved in redox reactions in methanogens HMNZS Tutira F420 , a 1948 Loch class frigate of the Royal New Zealand Navy Letter NumberCombDisambig ... more details
neonatal onset primary coenzymeQ10 deficiency a potentially treatable form of mitochondrial ...PBB geneid 57017 Ubiquinone biosynthesis protein COQ9, mitochondrial , also known as coenzyme Q9 homolog COQ9 , is a protein that in humans is encoded by the COQ9 gene . ref name entrez cite web title Entrez Gene coenzyme Q9 homolog S. cerevisiae url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 57017 accessdate ref Function This locus represents a mitochondrial coenzymeQ10 ubiquinone biosynthesis gene. The encoded protein is likely necessary for biosynthesis of coenzymeQ10 , as mutations at this locus have been associated with autosomal recessive neonatal onset primary coenzymeQ10 deficiency. ref name entrez Clinical significance It may be associated with CoenzymeQ10 deficiency . ref OMIM 607426 ref Model organisms class wikitable sortable collapsible collapsed border 1 cellpadding 2 style float right Coq9 knockout mouse phenotype Characteristic Phenotype Homozygote viability bgcolor 488ED3 Normal Fertility bgcolor 488ED3 Normal Body weight bgcolor 488ED3 Normal Open Field animal test Anxiety bgcolor C40000 Abnormal ref name Anxiety cite web url http www.sanger.ac.uk mouseportal phenotyping MCJR open field title Anxiety data for Coq9 publisher Wellcome Trust Sanger Institute ref Neurological assessment bgcolor 488ED3 Normal Grip strength bgcolor 488ED3 Normal Hot plate test Hot plate bgcolor 488ED3 Normal Dysmorphology bgcolor 488ED3 Normal ref name Dysmorphology cite web url http www.sanger.ac.uk mouseportal phenotyping MCJR dysmorphology title Dysmorphology data for Coq9 publisher Wellcome Trust Sanger Institute ref Indirect calorimetry bgcolor 488ED3 Normal Glucose tolerance test bgcolor 488ED3 Normal Auditory brainstem response bgcolor 488ED3 Normal Dual energy X ray absorptiometry DEXA bgcolor 488ED3 Normal Radiography bgcolor 488ED3 Normal Body temperature bgcolor 488ED3 Normal Eye morphology bgcolor 488ED3 Normal Clinical chemistry ... more details
protein Name hydroxyacyl Coenzyme A dehydrogenase 3 ketoacyl Coenzyme A thiolase enoyl Coenzyme A hydratase trifunctional protein , alpha subunit caption image width HGNCid 4801 Symbol HADHA AltSymbols EntrezGene 3030 OMIM 600890 RefSeq NM 000182 UniProt P40939 PDB ECnumber 1.1.1.211 Chromosome 2 Arm p Band 23 LocusSupplementaryData HADHA is a gene associated with long chain 3 hydroxyacyl coenzyme A dehydrogenase deficiency . See also Mitochondrial trifunctional protein biochem stub Multienzyme complexes Lipid metabolism enzymes ... more details
hydroxybenzoate polyprenyl transferase COQ2 causes primary coenzymeQ10 deficiency journal Am. J. Hum ... author Esaka Y, Nagahara Y, Hasome Y, et al. title Coenzyme Q2 induced p53 dependent apoptosis journal ... cite journal author Gonz lez Arag n D, Bur n MI, L pez Lluch G, et al. title Coenzyme ... more details
, Vitamin E, and CoenzymeQ10 for the prevention and treatment of cardiovascular disease. The groups ... of the program which studied the effect of supplemental antioxidants Vitamin C , Vitamin E, and CoenzymeQ10 for the prevention and treatment of cardiovascular disease. The groups findings were published ... more details
Energy gels are carbohydrate gels that provide energy for exercise and promote recovery, ref name aboutgu About http www.guenergy.net GU Energy Gel http walking.about.com library weekly ucgu.htm ref ref name halfrunning Energy gel for running how to use, ingredients and selection http www.half marathon running.com energy gel.html ref commonly used in endurance events such as running , cycling , and triathlon s. Energy gels are also referred to as endurance gels, sports gels, nutritional gels, and carbohydrate gels. ref name halfrunning They come in small, single serve plastic packets. Each packet has a strip with a small notch at the top that can be peeled off to reveal an opening through which the gel can be consumed. ref name halfrunning Nutritional behavior Once consumed, the carbohydrates found in the gels are absorbed into the blood to supply the body with calorie s and nutrient s to fuel exercise activity by helping to delay muscular fatigue, raise blood sugar levels, and enhance performance. ref name runningtimes Running Times Magazine Running Time s Guide to Sports Drinks and Gels http runningtimes.com Article.aspx?ArticleID 6677&PageNum 4 ref Most energy gels have no fat , fiber , or protein , so they can be digested quickly. ref name aboutgu They contain mainly sugar sugars and maltodextrin maltodextrins , which make them similar to sports drink s without the water. ref name rwgel Carbohydrates for Runners at Runner s World.com http www.runnersworld.com article 0,7120,s6 242 301 5956 2 1X2X3 4,00.html ref Some gels, such as e Gel, ref e Gel Electrolyte Energy Gel http www.cranksports.com products eGel ref also come with added electrolyte electrolytes . ref name rwgel There are also gels with extras such as ginseng and other herbs, amino acid amino acids , vitamin vitamins , and Coenzyme Q10 . ref name rwgel Caffeine can be found in some gels as well. ref name rwgel Examples of common energy gels are GU food GU , ref GU Energy Products http www.guenergy.com ... more details
. Studies have shown that low dosages of CoenzymeQ10 reduce this oxidation, and a combination of a diet rich in polyunsaturated fatty acids and CoenzymeQ10 supplementation leads to a longer lifespan in rats. ref name pmid 15036411 cite journal title Coenzyme Q supplementation protects from age .... It is advised that the level of polyunsaturated fats in the diet be regulated if CoenzymeQ10 supplements are not being taken. However, even without CoenzymeQ10 supplementation, the effect on health ... more details
PBB geneid 23590 Decaprenyl diphosphate synthase subunit 1 is an enzyme that in humans is encoded by the PDSS1 gene . ref name pmid10972372 cite journal author Rotig A, Appelkvist EL, Geromel V, Chretien D, Kadhom N, Edery P, Lebideau M, Dallner G, Munnich A, Ernster L, Rustin P title Quinone responsive multiple respiratory chain dysfunction due to widespread coenzyme Q10 deficiency journal Lancet volume 356 issue 9227 pages 391 395 year 2000 month Sep pmid 10972372 pmc doi 10.1016 S0140 6736 00 02531 9 ref ref name entrez cite web title Entrez Gene PDSS1 prenyl decaprenyl diphosphate synthase, subunit 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 23590 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is an enzyme that elongates the prenyl side chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. ref name entrez References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Appelkvist EL title Regulation of coenzyme Q biosynthesis journal Mol. Aspects Med. volume 15 Suppl issue pages s37 46 year 1995 pmid 7752843 doi author separator , author2 Aberg F author3 Guan Z display authors 3 last4 Parmryd first4 I last5 Dallner first5 G cite journal author Runquist M title Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans prenyltransferase journal J. Biol. Chem. volume 269 issue 8 pages 5804 9 year 1994 pmid 8119922 doi author ... more details
chembox verifiedrevid 277881712 ImageFile Octanoyl coenzyme A.svg ImageSize 300px IUPACName OtherNames Section1 Chembox Identifiers CASNo 1264 52 4 PubChem 380 SMILES MeSHName octanoyl coenzyme A Section2 Chembox Properties Formula C sub 29 sub H sub 50 sub N sub 7 sub O sub 17 sub P sub 3 sub S MolarMass 893.732 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Octanoyl coenzyme A is the endpoint of beta oxidation in peroxisome s. biochemistry stub Category Coenzymes fa fr Octanoyl coenzyme A ... more details
orphan date February 2009 Infobox disease ICD10 ICD10 Q 10 3 q10 Epiblepharon is characterised by a Congenital disorder congenital horizontal fold of skin near the margin of the upper or lower eyelid caused by the abnormal insertion of Skeletal muscle muscle fibres . Category Diseases of the eye and adnexa disease stub it Epiblefaron ... more details
Lead too short date September 2009 chembox verifiedrevid 319493451 ImageFile Isovaleryl coenzyme A.svg ImageSize 300px IUPACName OtherNames Section1 Chembox Identifiers CASNo 6244 91 3 PubChem 810 SMILES MeSHName isovaleryl coenzyme A Section2 Chembox Properties Formula C sub 26 sub H sub 44 sub N sub 7 sub O sub 17 sub P sub 3 sub S MolarMass 851.652 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Isovaleryl coenzyme A is an intermediate in branched chain amino acids metabolism. See also Isovaleryl coenzyme A dehydrogenase Amino acid metabolism intermediates References Reflist DEFAULTSORT Isovaleryl Coa Category Coenzymes biochem stub fa fr Isoval ryl coenzyme A ja CoA ... more details
food supplements CoenzymeQ10 , L Carnitine , Taurine and D Ribose, and there is some evidence for the benefits of CoenzymeQ10 in treating heart failure. ref cite journal author Langsjoen PH, Langsjoen PH, Folkers K title A six year clinical study of therapy of cardiomyopathy with coenzymeQ10 journal Int J Tissue React. volume 12 issue 3 pages 169 71 year 1990 pmid 2276895 ref ref cite journal author Folkers K, Langsjoen P, Langsjoen PH title Therapy with coenzymeQ10 of patients in heart ... of coenzymeQ10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators ... more details
HT, Rosendorff C, Silverman JM ref CoQ10 Ubiquinone Inhibition CoenzymeQ10 CoQ10 also known as Ubiquinone ... May title Citizens petition filed with FDA to include coenzymeQ10 use recommendation in all statin ... filed in 1990. ref name Brown MS. Coenzyme q 1990 ref name Tobert JA. Coenzyme q 1990 A citizen s petition ... more details
enzyme Name hydroxymethylglutaryl CoA hydrolase EC number 3.1.2.5 CAS number 9025 89 2 IUBMB EC number 3 1 2 5 GO code 0047994 image width caption In enzymology , a hydroxymethylglutaryl CoA hydrolase EC number 3.1.2.5 is an enzyme that catalysis catalyzes the chemical reaction S 3 hydroxy 3 methylglutaryl CoA H sub 2 sub O math rightleftharpoons math CoA 3 hydroxy 3 methylglutarate Thus, the two substrate biochemistry substrates of this enzyme are S 3 hydroxy 3 methylglutaryl CoA and water H sub 2 sub O , whereas its two product chemistry products are coenzyme A CoA and 3 hydroxy 3 methylglutarate. This enzyme belongs to the family of hydrolase s, specifically those acting on thioester bonds. The systematic name of this enzyme class is S 3 hydroxy 3 methylglutaryl CoA hydrolase. Other names in common use include beta hydroxy beta methylglutaryl coenzyme A hydrolase, beta hydroxy beta methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3 hydroxy 3 methylglutaryl CoA hydrolase. References reflist 1 cite journal author DEKKER EE, SCHLESINGER MJ, COON MJ date 1958 title beta Hydroxy beta methylglutaryl coenzyme A deacylase journal J. Biol. Chem. volume 233 pages 434&ndash 8 pmid 13563516 issue 2 hydrolase stub Category EC 3.1.2 Category Enzymes of unknown structure ... more details
chembox verifiedrevid 265862835 ImageFile Isobutyryl coenzyme A.png ImageSize 250px IUPACName small S 2 3 nowiki nowiki 4 nowiki nowiki 5 6 Aminopurin 9 yl 4 hydroxy 3 phosphonooxyoxolan 2 yl methoxy hydroxyphosphoryl oxy hydroxyphosphoryl oxy 2 hydroxy 3,3 dimethylbutanoyl amino propanoylamino ethyl 2 methylpropanethioate small OtherNames Isobutyryl coenzyme A Section1 Chembox Identifiers CASNo 15621 60 0 PubChem 808 SMILES CC C C O SCCNC O CCNC O C C C C COP O O OP O O OCC1C C C O1 N2C NC3 C2N CN C3N O OP O O O O MeSHName Isobutyryl coenzyme A Section2 Chembox Properties Formula C sub 25 sub H sub 42 sub N sub 7 sub O sub 17 sub P sub 3 sub S MolarMass 837.62 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Isobutyryl coenzyme A is an intermediate in the metabolism of valine . See also Isobutyryl CoA mutase Isobutyryl coenzyme A dehydrogenase deficiency Amino acid metabolism intermediates Category Coenzymes organic compound stub fa fr Isobutyryl coenzyme A ja CoA ... more details
, as they can, in rare cases, develop into more serious problems. CoenzymeQ10 supplementation ... C, Naini AB, Lucchini V, et al. title Muscle coenzymeQ10 level in statin related myopathy journal ... acting adrenergic beta agonists LABAs Hydroxymethylglutaryl coenzyme A reductase inhibitors statins ... more details
oxidase diverges from the cytochrome linked electron transport chain at the coenzymeQ10 ubiquinone ... that target Coenzyme Q cytochrome c reductase complex III , such as azoxystrobin, picoxystrobin ... more details
Unreferenced date December 2009 Protein Name acyl Coenzyme A dehydrogenase, long chain caption image width HGNCid 88 Symbol ACADL AltSymbols EntrezGene 33 OMIM 609576 RefSeq NM 001608 UniProt P28330 PDB ECnumber 1.3.99.3 Chromosome 2 Arm q Band 34 LocusSupplementaryData q35 ACADL is a gene associated with long chain 3 hydroxyacyl coenzyme A dehydrogenase deficiency . See also Acyl CoA dehydrogenase Lipid metabolism enzymes DEFAULTSORT Acadl Biochem stub es ACADL ... more details
enzyme Name glutathione CoA glutathione transhydrogenase EC number 1.8.4.3 CAS number 37256 48 7 IUBMB EC number 1 8 4 3 GO code 0047140 image width caption In enzymology , a glutathione CoA glutathione transhydrogenase EC number 1.8.4.3 is an enzyme that catalysis catalyzes the chemical reaction CoA glutathione disulfide math rightleftharpoons math CoA glutathione glutathione Thus, the two substrate biochemistry substrates of this enzyme are coenzyme A CoA and glutathione disulfide , whereas its two product chemistry products are CoA glutathione and glutathione . This enzyme belongs to the family of oxidoreductase s, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is CoA glutathione disulfide oxidoreductase . Other names in common use include glutathione coenzyme A glutathione disulfide transhydrogenase , glutathione coenzyme A glutathione disulfide transhydrogenase , glutathione coenzyme A glutathione transhydrogenase , glutathione coenzyme A glutathione transhydrogenase , coenzyme A oxidized glutathione oxidoreductase , and coenzyme A glutathione disulfide oxidoreductase . This enzyme participates in cysteine metabolism and glutathione metabolism . References reflist 1 cite journal author Chang SH, Wilken DR date 1966 title Participation of the unsymmetrical disulfide of coenzyme A and glutathione in an enzymatic sulfhydryl disulfide interchange. I Partial purification and properties of the bovine kidney enzyme journal J. Biol. Chem. volume 241 pages 4251&ndash 60 pmid 5924646 issue 18 1.8 enzyme stub Category EC 1.8.4 Category Enzymes of unknown structure it Glutatione CoA glutatione transidrogenasi ja CoA ... more details
enzyme Name 4 Coumarate CoA ligase EC number 6.2.1.12 CAS number 37332 51 7 IUBMB EC number 6 2 1 12 GO code 0016207 image width caption In enzymology , a 4 coumarate CoA ligase EC number 6.2.1.12 is an enzyme that catalysis catalyzes the chemical reaction ATP 4 coumarate CoA math rightleftharpoons math AMP diphosphate 4 coumaroyl CoA The 3 substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP , 4 coumarate , and coenzyme A CoA , whereas its 3 product chemistry products are adenosine monophosphate AMP , diphosphate , and 4 coumaroyl CoA . This enzyme belongs to the family of ligase s, to be specific those forming carbon sulfur bonds as acid thiol ligases. The systematic name of this enzyme class is 4 coumarate CoA ligase AMP forming . Other names in common use include 4 coumaroyl CoA synthetase , p coumaroyl CoA ligase , p coumaryl coenzyme A synthetase , p coumaryl CoA synthetase , p coumaryl CoA ligase , feruloyl CoA ligase , hydroxycinnamoyl CoA synthetase , 4 coumarate coenzyme A ligase , caffeolyl coenzyme A synthetase , p hydroxycinnamoyl coenzyme A synthetase , feruloyl coenzyme A synthetase , sinapoyl coenzyme A synthetase , 4 coumaryl CoA synthetase , hydroxycinnamate CoA ligase , p coumaryl CoA ligase , p hydroxycinnamic acid CoA ligase , and 4CL . This enzyme participates in phenylpropanoid biosynthesis . References reflist 1 cite journal author Gross GG, Zenk MH date 1974 title Isolation and properties of hydroxycinnamate CoA ligase from lignifying tissue of Forsythia journal Eur. J. Biochem. volume 42 pages 453 9 pmid 4364250 doi 10.1111 j.1432 1033.1974.tb03359.x issue 2 cite journal author Lindl T, Kreuzaler F, Hahlbrock K date 1973 title Synthesis of p coumaroyl coenzyme a with a partially purified p coumarate CoA ligase from cell suspension cultures of soybean Glycine max journal Biochim. Biophys. Acta. volume 302 pages 457 64 pmid 4699252 issue 2 ligase stub Category EC 6.2.1 Category Enzymes of unknown structure fr 4 coum ... more details
Infobox disease Name Succinyl CoA 3 oxoacid CoA transferase deficiency Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM 245050 MedlinePlus eMedicineSubj eMedicineTopic MeshID Succinyl CoA 3 oxoacid CoA transferase deficiency is an inborn error of ketone body utilization. Succinyl CoA 3 oxoacid CoA transferase catalyzes the transfer of Coenzyme A from Succinyl Coenzyme A to acetoacetate . It can be caused by mutation in the OXCT1 gene. Disease stub Category Inborn errors of metabolism ... more details
chembox verifiedrevid 401158853 ImageFile Methylcrotonyl coenzyme A.svg ImageSize 300px IUPACName OtherNames Section1 Chembox Identifiers CASNo 6247 62 7 PubChem 1138 SMILES MeSHName Methylcrotonyl CoA Section2 Chembox Properties Formula C sub 26 sub H sub 42 sub N sub 7 sub O sub 17 sub P sub 3 sub S MolarMass 849.636 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 3 Methylcrotonyl CoA or Methylcrotonyl CoA is an intermediate in the metabolism of leucine . It is formed from isovaleryl coenzyme A by isovaleryl coenzyme A dehydrogenase . See also Methylcrotonyl CoA carboxylase Amino acid metabolism intermediates Category Coenzymes biochem stub fa fr 3 m thylcrotonyl coenzyme A ja 3 CoA ... more details
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