Cyclamate Structural Formulae .V.1.svg ImageSize IUPACName sodium N cyclohexylsulfamate OtherNames ... Autoignition Sodium cyclamate sweetener code 952 is an artificial sweetener . It is 30&ndash 50 ... synergistically with other artificial sweeteners, especially saccharin the mixture of 10 parts cyclamate .... Chemistry Cyclamate is the sodium or calcium salt of cyclamic acid cyclohexanesulfamic acid , which ... No Cyclamate Just Add Sugar Cyclamate was discovered in 1937 at the University of Illinois at Urbana ... he put it back in his mouth , he discovered the sweet taste of cyclamate. ref cite book author Packard ... 8 oclc doi accessdate ref The patent for cyclamate was purchased by DuPont but later sold to Abbott ... intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital . In the US in 1958, it was designated GRAS Generally Recognized as Safe . Cyclamate was marketed ... when, in 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce ... resulted in a 1969 study that found the common 10 1 cyclamate saccharin mixture to increase ... additives title Potential side effects of Cyclamate ref On October 18, 1969, the Food and Drug Administration ... mutations and defects, reduce testosterone or shrivel the testes. In the same month, cyclamate was approved ... without restriction in the UK and Europe. As cyclamate is stable in heat, it was and is marketed as suitable ... http www.cyclamate.com cyctable.html title Worldwide Approval of Cyclamate ref Abbott Laboratories ... petitioned the FDA to lift the ban on cyclamate. This petition was eventually denied in 1980 by FDA ... stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States. The petition is now held ... by the FDA. Status Cyclamate is approved as a sweetener in over 55 countries, ref http www.cyclamate.com ... title Tastes like sugar accessdate 1 November 2010 ref for Canada contain cyclamate, though not for those ... more details
enzyme Name cyclamate sulfohydrolase EC number 3.10.1.2 CAS number 52228 00 9 IUBMB EC number 3 10 1 2 GO code 0018789 image width caption In enzymology , a cyclamate sulfohydrolase EC number 3.10.1.2 is an enzyme that catalysis catalyzes the chemical reaction cyclohexylsulfamate H sub 2 sub O math rightleftharpoons math cyclohexylamine sulfate Thus, the two substrate biochemistry substrates of this enzyme are cyclohexylsulfamate and water H sub 2 sub O , whereas its two product chemistry products are cyclohexylamine and sulfate . This enzyme belongs to the family of hydrolase s, specifically those acting on sulfur nitrogen bonds. The systematic name of this enzyme class is cyclohexylsulfamate sulfohydrolase . Other names in common use include cyclamate sulfamatase , cyclamate sulfamidase , and cyclohexylsulfamate sulfamidase . This enzyme participates in caprolactam degradation. References reflist 1 cite journal author Nimura T, Tokieda T, Yamaha T date Tokyo title Partial purification and some properties of cyclamate sulfamatase journal J. volume Biochem. pages 407&ndash 17 pmid 4209783 issue 2 hydrolase stub Category EC 3.10.1 Category Enzymes of unknown structure ... more details
Image Assugrin f3453504.jpg thumb Packets of Assugrin, a brand of cyclamate sugar substitute . Assugrin is a brand name for a sugar substitute that is a blend of cyclamate and saccharin . ref Gorman s New Product News. May 11, 1992 West Germany. new food products from different firms The Deluge Pours On Product Announcement Volume 28 Issue 4 Page 53 ref Produced in Switzerland by MCM Klosterfrau Vertriebsgesellschaft, ref Frost & Sullivan. May 5, 1997 http news.google.com archivesearch?q Both Hermesetas and Assugrin are produced in Switzerland and. &btnG Search&hl en&um 1&ie UTF 8 Euro Special & Dietetic Foods Hermes Susstoff AG ref Assugrin is the main table sweetener in West Germany . ref Lebensmittel Praxis. April 7, 1989 W. Germany Market for table sweeteners static. Page 46. ref History Cyclamate sugar substitute was discovered in 1937 by two American chemists and tested over the subsequent twenty years. After cyclamate was declared safe for consumption in the mid 1950s, the Hermes Company announced their new product, Assugrin, in 1954. ref name turnover Swiss Business Digest. June 18, 2004 Swiss Hermes Edulcorants 2003 Turnover at 44.4 Mln Euro. ref Almost a decade later, in 1965, Hermes company came up with a mixture of saccharin and cyclamate . It was later introduced to the market under Assugrin brand with wide endorsements. In that same year, aspartame was discovered. Aspartame was introduced into the Assugrin brand as Assugrin Gold. In 1987, orange and lemon varieties were added to the West German low calorie soft drink Assugrin Exquisit. ref European New Product Report. October 2, 1987 New flavours for Assugrin Exquisit. W. German New flavours for Assugrin Exquisit. Page 35. ref In 1990, Albi launched Assugrin Aktiv Iso Mineral Fitness Drink , a reduced calorie sports drink . ref Lebensmittel Praxis. April 6, 1990 W Germany Albi launches fitness drink. Page ..., water, artificial sweeteners, and sodium cyclamate. ref International Product Alert November ... more details
chembox verifiedrevid 444359109 ImageFile Ref chemboximage correct ?? ImageFile Cyclamic acid 2D skeletal.png ImageName Skeletal formula of cyclamic acid ImageFile1 Cyclamic acid 3D balls.png ImageName1 Ball and stick model of cyclamic acid OtherNames cyclohexylsulfamic acid Section1 Chembox Identifiers UNII Ref fdacite correct FDA UNII HN3OFO5036 KEGG Ref keggcite correct kegg KEGG D02442 InChI 1 C6H13NO3S c8 11 9,10 7 6 4 2 1 3 5 6 h6 7H,1 5H2, H,8,9,10 InChIKey HCAJEUSONLESMK UHFFFAOYAT StdInChI Ref stdinchicite correct chemspider StdInChI 1S C6H13NO3S c8 11 9,10 7 6 4 2 1 3 5 6 h6 7H,1 5H2, H,8,9,10 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey HCAJEUSONLESMK UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 100 88 9 PubChem 7533 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 7252 ChEBI Ref ebicite correct EBI ChEBI 15964 SMILES O S O O NC1CCCCC1 Section2 Chembox Properties C 6 H 13 S 1 N 1 O 3 S 1 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Cyclamic acid is a Compound chemistry compound with formula C sub 6 sub H sub 11 sub NHSO sub 2 sub OH. It is included in E number E952 . Cyclamic Acid is mainly used as catalyst in the production of paints and plastics, and furthermore as reagent for laboratories. The sodium and calcium salts of cyclamic acid are used as artificial sweetener s under the name cyclamate . The sodium form of this compound which is much more likely to be a carcinogen is banned in the USA and other countries for use as a sweetener. In the UK it used to be banned, but now it is allowed. ref Cyclamate website http www.cyclamate.com cyctable.html ref This is also sometimes considered to be a carcinogen . Citation needed date January 2012 References references Category Sulfonic acids Category Amines organic compound stub fr Acide cyclamique nl Cyclaamzuur sv Cyklaminsyra ... more details
Herbert Leonard Ley, Jr. September 7, 1923 &ndash July 22, 2001 was an United States American physician and government official . Biography He attended Harvard College from 1941 1943, and returned there after World War II , where he received his M.D. degree, cum laude , in 1946. In 1951, he earned an Master of Public Health degree from the Harvard School of Public Health . From 1951 until 1958, he worked with the Army Medical Service Graduate School in rickettsial disease research, the Office of the Surgeon General , and as an epidemiologist in Korea and Vietnam . In 1958, he accepted a position as Professor of Bacteriology and Chairman of the Department of Bacteriology, Hygiene, and Preventive Medicine at George Washington University . In 1963, he was appointed Associate Professor of Epidemiology and Microbiology at the Harvard School of Public Health, and became chairman of the Department in 1964. In September 1966, Ley took a leave of absence from his position to become Medical Director at the Food and Drug Administration On October 21, 1969, Abbott Laboratories reported that the artificial sweetener cyclamate in a saccharin cyclamate mixture had caused liver tumor s in rats. Cyclamates were removed from the list of Generally recognized as safe GRAS ingredients at Dr. Ley s direction on October 30, 1969. Frustrated with the red tape and conflicts with pharmaceutical companies, Ley resigned his position at FDA on December 11, 1969. His activism earned him a spot on the master list of Nixon political opponents . References http www.fda.gov AboutFDA CommissionersPage PastCommissioners ucm113447.htm Herbert L. Ley Jr. biography via FDA Bernstein, Adam August 15, 2001 . Herbert L. Ley Jr. Dies at Age 77 Physician Led FDA in Late 1960s. Washington Post Persondata Metadata see Wikipedia Persondata . NAME Ley, Herbert ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH September 7, 1923 PLACE OF BIRTH DATE OF DEATH July 22, 2001 PLACE OF DEATH DEFAULTSORT Ley, Herbert Cate ... more details
The 2005 Indonesia food scare was a food scare in 2005 in Jakarta , Indonesia, when the government found that 60 of noodle shops in the capital had been serving noodles laced with formaldehyde , a known carcinogen . Noodles in the 2007 Vietnam food scare also had the same contaminant, and the chemical preservative had also definitely been found on tofu , noodles, and salted fish. Thailand ref cite news url http asiarecipe.com thaivegg.html title The truth about your veggies last Sukrung first Karnjariya work Bangkok Post accessdate 2 January 2009 DASHBot archiveurl http web.archive.org web 20090123164057 http asiarecipe.com thaivegg.html archivedate 23 January 2009 deadurl no ref has similar formaldehyde problems. Rumors spread that it was used on chicken as well. ref cite web url http www.pss.org.sg main content view 94 2 title Formaldehyde food scare in Indonesia date January 9, 2006 work Sydney Morning Herald publisher Pharmaceutical Society of Singapore accessdate 2 January 2009 DASHBot archiveurl http web.archive.org web 20081120091407 http www.pss.org.sg main content view 94 2 archivedate 20 November 2008 deadurl no ref This was particularly bad in a nation like Indonesia where chicken is widely consumed because of the Islamic stance on pork. Other food contaminants found by Depok Health agency in elementary schools in 2006 were sodium benzoate , cyclamate and borax exceeding the permissible levels. Benzoate and cyclamate were commonly used as food additives in Indonesia. Other substances found in the samples, such as borax , rhodamine , formaldehyde and yellow methanil used as a dye are not fit for consumption. See also Food contamination 2008 Chinese milk scandal References reflist External links http www.thejakartapost.com news 2006 12 22 formaldehyde found school snacks.html Formaldehyde found in school snacks Consumer Food Safety Category Food safety scandals Category 2005 in Indonesia Indonesia Food Scare, 2005 Category Food scares Category History of Ja ... more details
unreferenced date April 2011 Infobox Beverage name Diet Rite Pure Zero image Image Diet Rite.JPG type Diet soda Diet Cola manufacturer Cott Beverages and Dr Pepper Snapple Group origin United States introduced 1958 discontinued related Diet Coke , Diet Pepsi , Tab soft drink Tab Diet Rite is a brand of no calorie soft drinks originally distributed by the RC Cola company. It was introduced in 1958 and initially released as a dietetic product, but was marketed to the general public as a healthful beverage in 1962. The original formula was sweetened with cyclamate and saccharin . Today it is owned by and distributed by Dr Pepper Snapple Group known until 2008 as Cadbury Schweppes Americas Beverages , after the merger with Dr Pepper Seven Up . Product containers, however, still bear the Dr Pepper Seven Up markings. The early 1960s broadcast media advertising campaign featured a jingle with the lyrics Diet Rite Cola Good for you and children too Because it hasn t got Any sugar at all ... new Diet Rite Cola Reformulation By 1969, the Food and Drug Administration banned cyclamate , forcing the beverage to be reformulated with saccharin . Diet Rite was reformulated in 1983 to eliminate sodium, making it the first sodium free diet soda. In 1987, after having used a blend of the two sweeteners, the saccharin was replaced entirely with NutraSweet brand aspartame and eliminating caffeine altogether. In the 1990s, several fruit flavored varieties of Diet Rite were introduced. In 2000, the line was reformulated yet again, this time to replace aspartame with Splenda brand sucralose and Sunett brand Acesulfame potassium . It became the first major diet soda in the United States to use neither aspartame nor saccharin as a sweetener. In 2005, Pure Zero was added to the name, and a cherry cola flavor was introduced in 2006. Brand decline As of 2011 , most stores in the United States only carry the cola flavor, and to a lesser extent red raspberry. Kiwi strawberry is no longer availabl ... more details
Image Suomenlinna picnic.jpg thumb right 270px Two Finns enjoying a magnum bottle of Pommac Pommac is a carbonated soft drink made of fruits and berries and matured in oak aging barrel barrels for 3 months. The name comes from Pommery , referring to Champagne wine Champagne , and Cognac , as it is matured on oak aging barrel barrels like wine . ref http www.drinkkiklubi.com tuote pommac Drinkkiklubi.com ref The recipe is kept a secret. In 1919, after his best efforts to keep his brewery running Anders Lindahl moved to Stockholm , Sweden as a failed businessman, and founded Fructus Fabriker and began to make Pommac. The recipe was made by a Finland Swedish inventor. The drink was made for the upper classes as an alcohol free substitute for wine. Dr Pepper distributed a formulation of it in the US as a diet drink from 1963 to 1969 in six and a half and ten ounce bottles. It took a while for people to become accustomed to the taste, so sales were slow. Citation needed date June 2009 When sales remained stagnant after six years, and its sweetener, sodium cyclamate , was banned, Dr Pepper discontinued the product. Citation needed date June 2009 Pommac is also served as a non alcoholic champagne alternative on festive occasions. In late 2004, Carlsberg Group Carlsberg in Denmark announced that they were going to cease production of Pommac for financial reasons. However, after overwhelming public demand including a petition tallying over 50,000 signatures Citation needed date June 2009 was raised in response, the company decided to keep marketing Pommac. References reflist Category Fruit sodas Category Finnish cuisine Category Swedish beverages Category Swedish cuisine es Pommac nl Pommac ja no Pommac fi Pommac sv Pommac ... more details
Otheruses Sweet and Low disambiguation File Sweet n Low.svg 176px thumb right File Sweet n Low Flushing Av jeh.jpg thumb upright Cumberland Packing, Cumberland Street, Brooklyn Sweet n Low trademarked as Sweet N Low is a brand of artificial sweetener made primarily from granulated saccharin . It also contains dextrose and cream of tartar , and distributed primarily in sugar packet packets . Sweet n Low is manufactured and distributed in the United States by Sugar Foods Corporation who also produce Sugar in the Raw and Stevia in the Raw , and in the United Kingdom by Dietary Foods Ltd . Its patent is US patent 3625711 . The trademark of words Sweet n Low and the musical staff logo is U.S. Trademark registration No. 1,000,000. The Pink Panther character The Pink Panther cartoon character has been the mascot for the brand since 2001, and appears on product packaging and marketing, including television commercials. In Canada , Sweet n Low is made from sodium cyclamate instead of saccharin. This is because saccharin has not been allowed as a food additive in Canada since the 1970s, when studies surfaced showing cancer resulting in laboratory rats that had been administered the additive. ref name SaccharinCanada cite web title Questions and Answers Saccharin work Health Canada Website url http www.hc sc.gc.ca fn an securit addit sweeten edulcor saccharin qa qr eng.php accessdate July 13, 2010 ref Canada is considering lifting this ban since the studies were recently proved faulty, and several other countries have lifted their saccharin bans and warnings. Sweet n Low has been licensed to Bernard Food Industries for a line of low calorie baking mixes. History Saccharin was first discovered in 1878 by Constantin Fahlberg , a chemist working on coal tar derivatives at the Johns Hopkins University . Although saccharin was commercialized not long after its discovery, it was not until decades later that its use became widespread. Sweet n Low was first introduced in 1957 by Benja ... more details
Refimprove date November 2011 Drugbox verifiedrevid 447812653 IUPAC name 4 dimethylamino 2 isopropyl 2 phenylpentanenitrile image isoaminile.png Clinical data tradename Drugs.com drugs.com international isoaminile pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number 77 51 0 ATC prefix R05 ATC suffix DB04 PubChem 6481 DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 6236 UNII Ref fdacite correct FDA UNII R4823W2PQL KEGG Ref keggcite correct kegg KEGG D08088 Chemical data C 16 H 24 N 2 molecular weight 244.375 g mol smiles N CC c1ccccc1 C C C CC N C C C InChI 1 C16H24N2 c1 13 2 16 12 17,11 14 3 18 4 5 15 9 7 6 8 10 15 h6 10,13 14H,11H2,1 5H3 InChIKey WFLSCFISQHLEED UHFFFAOYAP StdInChI Ref stdinchicite correct chemspider StdInChI 1S C16H24N2 c1 13 2 16 12 17,11 14 3 18 4 5 15 9 7 6 8 10 15 h6 10,13 14H,11H2,1 5H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey WFLSCFISQHLEED UHFFFAOYSA N Isoaminile was discovered by Hoechst AG in the 1950s ref DE Patent 1034649 ref . It is used under the trade name Peracon as an antitussive and is structurally related to methadone . Psychedelic drug Psychedelic effects have been noted from doses approximately 300 mg and above. The normal therapeutic dose is 40 80 mg of the cyclamate salt not to exceed five doses in a 24 hour period. In addition to central antitussive effects it is also an anticholinergic , exhibiting both antimuscarinic and antinicotinic actions. References Reflist 2 Cough and cold preparations Hallucinogens Category Synthetic opioids Category Amines Category N ... more details
. A 10 1 cyclamate saccharin blend is common in countries where both these sweeteners are legal in this blend ... containing Saccharin and CyclamateCyclamate Sucralose brand Splenda Aspartame found in blends ... more details
List of drugs S Sj So sk sn Skelaxin Skelex Skelid Skin Exposure Reduction Paste Against Chemical Warfare Agents Sleep Aid Sleep eze 3 Oral Sleepinal Sleepwell 2 nite Slim Mint Slo Bid Slo Niacin Slo Phyllin Slo Salt Slow K Slow Mag Slow Trasicor SMX TMP Snaplets EX so sob sobetirome United States Adopted Name USAN sobuzoxane International Nonproprietary Name INN sod sode sodelglitazar United States Adopted Name USAN sodi sodiu sodium sodium a sodium f sodium acetrizoate International Nonproprietary Name INN sodium amidotrizoate International Nonproprietary Name INN sodium apolate International Nonproprietary Name INN sodium ascorbate International Nonproprietary Name INN sodium aurothiomalate International Nonproprietary Name INN sodium aurotiosulfate International Nonproprietary Name INN sodium bitionolate International Nonproprietary Name INN sodium borocaptate 10 B International Nonproprietary Name INN sodium calcium edetate International Nonproprietary Name INN sodium chromate 51 Cr International Nonproprietary Name INN sodium cyclamate International Nonproprietary Name INN sodium dehydrocholate International Nonproprietary Name INN sodium dibunate International Nonproprietary Name INN sodium diprotrizoate International Nonproprietary Name INN sodium etasulfate International Nonproprietary Name INN sodium feredetate International Nonproprietary Name INN sodium ferric gluconate complex United States Adopted Name USAN sodium g sodium t sodium gentisate International Nonproprietary Name INN sodium glucaspaldrate International Nonproprietary Name INN sodium gualenate International Nonproprietary Name INN sodium hexacyclonate International Nonproprietary Name INN sodium iodide 125 I International Nonproprietary Name INN sodium iodide 131 I International Nonproprietary Name INN sodium iodohippurate 131 I International Nonproprietary Name INN sodium iopodate International Nonproprietary Name INN sodium iotalamate 125 I International Nonproprietary Name INN sodium iota ... more details
needed date February 2010 The 1960s In the 1960s, Pillsbury added Sweet 10 made with cyclamate , which ... in 1965, along with other flavors. When cyclamate was banned, Sweet 10 and Funny Face had to be dropped ... more details
sweeteners such as saccharin , cyclamate , aspartame , and acesulfame provide no food energy. Controversy over saccharin and cyclamate as artificial sweeteners still exists, but aspartame and acesulfame ... more details
of Cade s wife, the researchers added lemon juice and cyclamate ref name burnett4161994 Richard ... Administration FDA banned cyclamate as a potential carcinogen . ref to the original formula of water ... more details
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