Crystal structure of human CDK4 in complex with a D type cyclin journal Proc. Natl. Acad. Sci. U.S.A. ... ECnumber Chromosome 6 Arm p Band 21 LocusSupplementaryData CyclinD is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclinD is initiated during G1 and drives the G1 S phase transition. CyclinD protein is anywhere from 155 in zebra mussel ... through an APC c dependent pathway. CyclinD is one of the major cyclins produced in terms of its ... D Cdk4 6 complex accumulation is of great importance for cell cycle progression. Namely, cyclin ... have one cyclinD protein. In humans, in addition to the mouse homologue, two more cyclinD proteins ... name curie Homologues The most studied homologues of cyclinD are found in yeast and virus es. The yeast homologue of cyclinD, referred to as CLN3 Cln3 , interacts with Cdc28 cell division control ... 8 Kaposi s sarcoma associated herpesvirus HHV 8 Kaposi s sarcoma associated herpesvirus cyclinD ... benefit. ref name Hardwick Viral cyclinD binds human Cyclin dependent kinase 6 Cdk6 and inhibits .... Other than Rb, viral cyclinD Cdk6 complex also targets CDKN1B p27 sup Kip sup , a Cdk inhibitor of cyclin E and A. In addition, viral cyclinD Cdk6 is resistant to Cdk inhibitors, such as p21 sup ... forming an active complex with cyclinD. ref name Hardwick ref name Kufe Function Cyclins in humans ... cyclinD production. One of the members of the pathways, MAPK activates a transcription factor Myc, which alters transcription of genes important in cell cycle, among which is cyclinD. In this way, cyclinD is synthesized as long as the growth factor is present. Even though cyclinD levels ... S transition is active cyclinD Cdk4 6 complexes. Despite this, cyclinD has no effect on G1 S transition unless it forms a complex with Cdk 4 or 6. One of the best known substrates of cyclinD Cdk4 ... cells from progressing through G1. Active cyclinD Cdk4 and 6 inhibit Rb by partial phosphorylation ... more details
, Cyclin A Cyclin dependent kinase 2 CDK2 active in S phase. CyclinDCyclin dependent kinase 4 CDK4 , CyclinDCyclin dependent kinase 6 CDK6 , and Cyclin E CDK2 regulates transition from G sub ..., Cig1? Cdk1 Cdc13 Cdk1 align center D. melanogaster cyclinD Cdk4 cyclin E Cdk2 cyclin E, A Cdk2,1 cyclin ... cyclin A, B, B3 Cdk1 align center H. sapiens cyclinD 1,2,3 Cdk4,6 cyclin E Cdk2 cyclin A Cdk2,1 ... C Cyclin C CCNC align center CyclinDDCyclin D1 CCND1 , Cyclin D2 CCND2 , Cyclin D3 CCND3 align ... cycle by activating cyclin dependent kinase Cdk enzyme s. ref name pmid12910258 cite journal title ... FP author3 Giordano A author separator , ref Function Image Cyclin Expression.svg thumb left 400px ... according to their conserved cyclin box structure, and not all these cyclins alter in level through ... ref The oscillations of the cyclins, namely fluctuations in cyclin gene expression and destruction by proteolysis, induce oscillations in Cdk activity to drive the cell cycle. A cyclin forms a complex ... 12 2011 hosted by Jim Al Khalili , R. Timothy Hunt explained that the name cyclin was originally ... BBC accessdate 13 December 2011 ref R.Timothy Hunt By the way the name cyclin, which I coined, was really ... p34 Cdk1 cdc2 or Cyclin dependent kinase 1 cdk1 proteins, form the maturation promoting factor ... rise in late G1 and fall in early S phase. The Cdk G1 S cyclin complex begins to induce the initial ... as well to promote early events in mitosis. M cyclin concentrations rise as the cell begins to enter ... of mitotic spindles and alignment of sister chromatids along the spindles are induced by M cyclin Cdk ... structure, or amino acid sequence. The similarity between members of the cyclin family are similar in the 100 amino acids that make up the cyclin box. Cyclins contain two protein domain domains of similar ... helices. The first of which is the conserved cyclin box, outside of which cyclins are divergent. For example ... these proteins for proteolysis in mitosis. valign top Pfam box Symbol Cyclin N Name Cyclin, N ... more details
protein Name CCNA1 cyclin A1 caption image width HGNCid 1577 Symbol CCNA1 AltSymbols EntrezGene 8900 OMIM 604036 RefSeq NM 003914 UniProt P78396 PDB ECnumber Chromosome 13 Arm q Band 12.3 LocusSupplementaryData q13 protein Name cyclin A2 caption image width HGNCid 1578 Symbol CCNA2 AltSymbols CCNA, CCN1 EntrezGene 890 OMIM 123835 RefSeq NM 001237 UniProt P20248 PDB ECnumber Chromosome 4 Arm q Band 27 LocusSupplementaryData Cyclin A is a member of the cyclin family. Cyclin A binds to S phase Cdk2 and is required for the cell to progress through the S phase . Cyclin A Cdk2 is inhibited by the complex p21CIP. Image Cyclinexpression waehrend Zellzyklus.png center 422px Expression of cyclins through the cell cycle . External links http www.sdbonline.org fly newgene cyclina1.htm Drosophila Cyclin A The Interactive Fly MeshName Cyclin A Cell cycle proteins Category Cell cycle Category Proteins Cell biology stub es Ciclina A ... more details
expression of cyclin E correlated with poorer prognosis. ref Huang L, Wang D, Chen Y, et al. Meta analysis ...protein Name CCNE1 cyclin E1 caption image width HGNCid 1589 Symbol CCNE1 AltSymbols CCNE EntrezGene ... protein Name CCNE2 cyclin E2 caption image width HGNCid 1590 Symbol CCNE2 AltSymbols EntrezGene ... Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase G sub 1 sub phase Cdk2 , which is required for the transition from G sub 1 sub to S phase . The Cyclin E CDK2 complex phosphorylation phosphorylates p27 sup Kip1 sup an Enzyme inhibitor inhibitor of CyclinD , tagging it for degradation, thus promoting expression of Cyclin A , allowing progression to S phase ... cycle . Functions of Cyclin E Like all cyclin family members, cyclin E forms a complex with cyclin dependent kinase CDK2 . Cyclin E CDK2 regulates multiple cellular processes by phosphorylating numerous downstream proteins. Cyclin E CDK2 plays a critical role in the G1 phase and in the G1 S phase transition. Cyclin E CDK2 phosphorylates Retinoblastoma Rb to promote G1 progression. Hyper phosphorylated ..., 70 993 1006 ref Cyclin E CDK2 also phosphorylates p27 and p21 during G1 and S phases, respectively ... by cyclin E CDK2. The phosphorylation of Smad3 by cyclin E CDK2 inhibits its transcriptional activity ... of cyclin E overexpression on Smad3 activity in breast cancer cell lines. Cell Cycle. 2010, 9 4900 4907 ref CBP p300 and E2F 5 are also substrates of cyclin E CDK2. Phosphorylation of these two proteins ... Thangue NB. Regulation of E2F transcription by cyclin E Cdk2 kinase mediated through p300 CBP co activators. Nat Cell Biol. 2000, 2 232 239 ref Cyclin E CDK2 can phosphorylate p220 NPAT to promote histone ... regulated phosphorylation of p220 NPAT by cyclin E Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 2000, 14 2298 2313 ref Apart from the function in cell cycle progression, cyclin ... duplication. ref Okuda M, Horn HF, Tarapore P, et al. Nucleophosmin B23 is a target of CDK2 cyclin E ... more details
The CyclinD Cdk4 complex is a compound structure of CyclinD and Cdk4 , regulated by the GATA1 GATA 1 transcription factor . ref cite journal author Muntean A, Pang L, Poncz M, Dowdy S, Blobel G, Crispino J title CyclinD Cdk4 is regulated by GATA 1 and required for megakaryocyte growth and polyploidization journal Blood volume 109 issue 12 pages 5199 207 year 2007 pmid 17317855 doi 10.1182 blood 2006 11 059378 pmc 1890844 ref See also Human papillomavirus References references biochemistry stub Category Cell cycle Category Human proteins Category Papillomavirus Category Protein complexes Category Transcription factors es Ciclina D Cdk4 ... more details
Liu D, Matzuk MM, Sung WK, et al. title Cyclin A1 is required for meiosis in the male mouse. journal ... Liu D, Liao C, Wolgemuth DJ title A role for cyclin A1 in the activation of MPF and G2 M transition ...PBB geneid 8900 Cyclin A1 is a protein that in humans is encoded by the CCNA1 gene . ref name pmid9041194 cite journal author Yang R, Morosetti R, Koeffler HP title Characterization of a second human cyclin ... section title summary text The protein encoded by this gene belongs to the highly conserved cyclin ... complex complex together with cyclin dependent kinases cyclin dependent kinases CDKs . Different cyclins ... of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis . This cyclin ..., the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind ... Cip family of CDK inhibitor proteins. ref name entrez Cite web title Entrez Gene CCNA1 cyclin ... ref Interactions Cyclin A1 Protein protein interaction interacts with E2F1 , ref name pmid10022926 ... H P year 1999 month March title Functions of cyclin A1 in the cell cycle and its interactions ... S, Hatakeyama M year 2000 month February title Human p55 CDC Cdc20 associates with cyclin A and is phosphorylated by the cyclin A Cdk2 complex journal Biochem. Biophys. Res. Commun. volume 268 ... protein , ref name pmid10022926 Cyclin dependent kinase 2 , ref name pmid9041194 cite journal ... title Characterization of a second human cyclin A that is highly expressed in testis and in several ... Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M year 1996 month January title A distinct cyclin A is expressed in germ cells in the mouse journal Development volume 122 ... C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P year 2001 month April title Cyclin A1 directly interacts with B myb and cyclin A1 cdk2 phosphorylate B myb at functionally important serine ... more details
Seghezzi W, Parry D, Mahony D, Lees E year 1999 month Feb. title Cyclin E associates with BAF155 ... D title Subunit rearrangement of the cyclin dependent kinases is associated with cellular transformation ...PBB geneid 891 G2 mitotic specific cyclin B1 is a protein that in humans is encoded by the CCNB1 gene ... 92 90190 4 ref Function Cyclin B1 is a regulatory protein involved in mitosis . The gene product complexes ... web title Entrez Gene CCNB1 cyclin B1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 891 accessdate ref Cyclin B1 contributes to the switch like all or none behavior ... loops ensure that once the cyclin B1 Cdk1 complex is activated it is not deactivated. Cyclin B1 ... breakdown, and spindle pole assembly. Once activated, cyclin B1 Cdk1 promotes several of the events .... Another important function of the cyclin B1 Cdk1 complex is to break down the nuclear envelope ... of Lamin nuclear lamins . Phosphorylation of the lamins by cyclin B1 Cdk1 causes them to dissociate ... Image Nsp cellcycle 5 3 5 8.jpg thumb 300px left Cyclin B1 accumulates throughout the cell ... cell cycle. Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation .... A possible trigger for activation is phosphorylation by cyclin A Cdk, which functions before cyclin B1 Cdk in the cell cycle. Active Cdk1 is also capable of phosphorylating and activating Cdc25 and thus promote its own activation, resulting in a positive feedback loop. Once cyclin B1 Cdk1 is activated, it remains stably active for the rest of mitosis. Another mechanism by which cyclin B1 Cdk1 activity is regulated is through subcellular localization. Before mitosis almost all cyclin ... by the phosphorylation of cyclin B1, in contrast to phosphorylation of Cdk1 regulating the activity of the complex. Phosphorylation of cyclin B1 causes it to be imported to the nucleus ... more details
kinase activity for cdk6, a novel cyclinD partner. journal Mol. Cell. Biol. volume 14 issue 3 ... AR, Shiffman D, Chan CS, et al. title Functional analysis of the human cyclin D2 and cyclin D3 promoters ... journal author G mez Lahoz E, Liegeois NJ, Zhang P, et al. title CyclinD and E dependent kinases ... cite journal author Choi D, Lee EY, Yoon S, et al. title Clinical correlation of cyclin ...PBB geneid 894 G1 S specific cyclin D2 is a protein that in humans is encoded by the CCND2 gene . ref ... AT title Genomic organization, chromosomal localization, and independent expression of human cyclinD genes journal Genomics volume 13 issue 3 pages 565 74 year 1992 month Aug pmid 1386335 pmc doi 10.1016 0888 7543 92 90126 D ref The PBB Summary template is automatically maintained by Protein Box Bot ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... of cyclin dependent kinases. Different cyclins exhibit distinct Gene expression expression and degradation patterns which contribute to the temporal coordination of each mitosis mitotic event. This cyclin ... web title Entrez Gene CCND2 cyclin D2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... citations cite journal author Xiong Y, Menninger J, Beach D, Ward DC title Molecular cloning and chromosomal mapping of CCND genes encoding human D type cyclins. journal Genomics volume 13 issue ..., Roussel MF, Kato JY, et al. title Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclinD dependent kinases CDK4 and CDK6. journal Mol. Cell. Biol. volume 15 issue 5 pages 2672 81 year ... protein with mammalian D type cyclins. journal Cell volume 73 issue 3 pages 487 97 year ... cite journal author Hirai H, Sherr CJ title Interaction of D type cyclins with a novel ... Cyclin D2 is an FSH responsive gene involved in gonadal cell proliferation and oncogenesis. journal ... Kitagawa M, Higashi H, Jung HK, et al. title The consensus motif for phosphorylation by cyclin ... more details
J D, Dutta A date May 1998 title Human CDC6 Cdc18 Associates with Orc1 and Cyclin cdk and Is Selectively ...PBB geneid 890 Cyclin A2 is a protein that in humans is encoded by the CCNA2 gene . ref name pmid1675006 ... in the human cyclin A gene journal Nucleic Acids Res volume 19 issue 9 pages 2516 date July 1991 ... summary text The protein encoded by this gene belongs to the highly conserved cyclin family, whose members ... patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin .... ref name entrez cite web title Entrez Gene CCNA2 cyclin A2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 890 accessdate ref See also Cyclin A Interactions Cyclin A2 has been shown to Protein protein interaction interact with ITGB3BP , ref name pmid10673397 ... M date January 2000 title beta3 endonexin as a novel inhibitor of cyclin A associated kinase ... K A, Peng C Y, Yee A S, Piwnica Worms H date December 1994 title Cyclin A CDK2 binds directly ... C S, Bartek J, Helin K date January 1999 title Phosphorylation of mammalian CDC6 by cyclin A CDK2 ... Koundrioukoff St phane, H bscher Ulrich date July 2003 title Phosphorylation of human Fen1 by cyclin ... F, et al. title Cyclin A is required at two points in the human cell cycle journal EMBO J. volume 11 ... T, Bornens M title Cytoplasmic accumulation of cyclin B1 in human cells association with a detergent ... between human cyclin A and adenovirus E1A associated p107 protein journal Science volume 255 issue ... LR, Adamczewski JP, Hunt T, La Thangue NB title Cyclin A and the retinoblastoma gene product complex ... of a human cyclin A gene to 4q26 q27 journal Genomics volume 8 issue 3 pages 595 7 year 1991 ..., Br chot C title Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma journal ... 7630397 doi 10.1038 376313a0 cite journal author Xu M, Sheppard KA, Peng CY, et al. title Cyclin A CDK2 ... more details
see also CyclinD PBB geneid 595 G1 S specific cyclin D1 is a protein that in humans is encoded by the CCND1 ... grap2 and cyclinD interacting protein, regulates E2F mediated transcriptional activity journal ... of cyclinD CDK4 journal Nature journal Nature volume 366 issue 6456 pages 704 7 publisher location ... Adnane first J authorlink coauthors Shao Z, Robbins P D year 1999 month January title Cyclin D1 ... A year 1994 month April title D type cyclin binding regions of proliferating cell nuclear antigen journal ... journal author Gautschi O, Ratschiller D, Gugger M, et al. title Cyclin D1 in non small cell lung ..., chromosomal localization, and independent expression of human cyclinD genes journal Genomics ... cite journal author Xiong Y, Connolly T, Futcher B, Beach D title Human D type cyclin journal Cell ... JV, Kronenberg HM, Arnold A title A novel cyclin encoded by a bcl1 linked candidate oncogene journal ... novel human cyclins by rescue of G1 cyclin Cln function in yeast journal Cell volume 66 issue 6 pages ... cyclin family, whose members are characterized by a dramatic periodicity in protein abundance ... mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of Cyclin dependent kinase 4 CDK4 or Cyclin dependent kinase 6 CDK6 , whose activity is required for cell cycle ... web title Entrez Gene CCND1 cyclin D1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 595 accessdate ref Image Mantle cell lymphoma intermed mag cyclin D1.jpg thumb right 125px Micrograph of cyclin D1 staining in a mantle cell lymphoma . Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma . Interactions Cyclin D1 has been ... month August title Cyclin D1 Is a Ligand independent Co repressor for Thyroid Hormone Receptors journal ... J L authorlink coauthors Rushton J J, Sellers W R, Kaelin W G, Robbins P D year 2000 month November title Cyclin D1 suppresses retinoblastoma protein mediated inhibition of TAFII250 kinase activity ... more details
CCND3 cyclin D3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 896 accessdate ref See also CyclinCyclinD Interactions Cyclin D3 has been shown to Protein protein ... X, Wolgemuth D J year 1999 month Jun. title Developmentally regulated expression of cyclin D3 and its ... of G1 kinase activity for cdk6, a novel cyclinD partner journal Mol. Cell. Biol. volume 14 issue 3 ... of G1 kinase activity for cdk6, a novel cyclinD partner. journal Mol. Cell. Biol. volume ... cite journal author Brooks AR, Shiffman D, Chan CS, et al. title Functional analysis of the human cyclin ... author G mez Lahoz E, Liegeois NJ, Zhang P, et al. title CyclinD and E dependent kinases and the p57 ... J, et al. title A cyclinD Cdk4 activity required for G2 phase cell cycle progression is inhibited ...PBB geneid 896 G1 S specific cyclin D3 is a protein that in humans is encoded by the CCND3 gene . ref ... AT title Genomic organization, chromosomal localization, and independent expression of human cyclinD genes journal Genomics volume 13 issue 3 pages 565 74 year 1992 month Aug pmid 1386335 pmc doi 10.1016 0888 7543 92 90126 D ref The PBB Summary template is automatically maintained by Protein Box Bot ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions ... protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell ... Alexandra, Rochette Egly C cile, Chomienne Christine, Delva Laurent year 2003 month Feb. title Cyclin ... Pierre P, Pirson Isabelle year 2004 month Mar. title A novel partner for D type cyclins protein ... kinase, with cyclin D3 journal J. Biol. Chem. volume 277 issue 38 pages 35314 22 publisher location ... format accessdate laysummary laysource laydate quote ref CRABP2 , ref name pmid12482873 Cyclin ..., Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi Guedehoussou Nono, Klitgord Niels ... more details
Mumberg D, Wick M, B rger C, et al. title Cyclin ET, a new splice variant of human cyclin E with a unique ...Cleanup date November 2007 PBB geneid 898 G1 S specific cyclin E1 is a protein that in humans is encoded ... of three novel human cyclins by rescue of G1 cyclin Cln function in yeast journal Cell volume ... to the Highly conserved sequence highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitosis mitotic event. This cyclin forms a complex with and functions ... Gene CCNE1 cyclin E1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 898 accessdate ref See also cyclin E Interactions Cyclin E1 has been shown to Protein protein ... Shanahan first F authorlink coauthors Seghezzi W, Parry D, Mahony D, Lees E year 1999 month February title Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI SNF complex, and alters ... Giordano A, Desai D, Yamashita K, Harper J W, Elledge S, Nishimoto T, Morgan D O, Franza B R, Roberts J M year 1992 month September title Formation and activation of a cyclin E cdk2 complex during ... laysource laydate quote ref Cyclin dependent kinase 2 , ref name pmid9891079 ref name pmid1388288 ... first A K authorlink coauthors Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D ... D H, Lees E year 2000 month November title BRG1, a component of the SWI SNF complex, is mutated ... name pmid10500095 cite journal doi 10.1101 gad.13.18.2375 last Singer first J D authorlink coauthors Gurian West M, Clurman B, Roberts J M year 1999 month September title Cullin 3 targets cyclin E for ubiquitination ... author Mazumder S, DuPree EL, Almasan A title A dual role of cyclin E in cell proliferation and apoptosis ... 10.1016 0092 8674 92 90249 C Cite journal author Koff A, Giordano A, Desai D, et al. title Formation and activation of a cyclin E cdk2 complex during the G1 phase of the human cell cycle. journal Science ... author Koff A, Cross F, Fisher A, et al. title Human cyclin E, a new cyclin that interacts with two ... more details
J, Lee G, Price D H, Flores O year 1999 month Dec. title Cyclin K functions as a CDK9 regulatory subunit ...PBB geneid 8812 Cyclin K is a protein that in humans is encoded by the CCNK gene . ref name pmid9632813 cite journal author Edwards MC, Wong C, Elledge SJ title Human Cyclin K, a Novel RNA Polymerase II Associated Cyclin Possessing Both Carboxy Terminal Domain Kinase and Cdk Activating Kinase Activity journal Mol Cell Biol volume 18 issue 7 pages 4291 300 year 1998 month Jul pmid 9632813 pmc 109013 doi ref ref name pmid10574912 cite journal author Fu TJ, Peng J, Lee G, Price DH, Flores O title Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription journal J Biol Chem volume 274 issue 49 pages 34527 30 year 2000 month Feb pmid 10574912 pmc doi 10.1074 jbc.274.49.34527 ref ref name entrez cite web title Entrez Gene CCNK cyclin K url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 8812 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB ... cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin dependent kinases CDK that phosphorylate the C terminal domain CTD of the large subunit ... II activities. ref name entrez Interactions Cyclin K has been shown to Protein protein interaction ... R, Fujinaga K, Peterlin BM title P TEFb containing cyclin K and Cdk9 can activate transcription via ... jbc.M200117200 cite journal author Mori T title Cyclin K as a Direct Transcriptional Target of the p53 ... separator , author2 Jedrychowski M author3 Schwartz D display authors 3 last4 Elias first4 JE ... first5 Am lie last6 Li first6 Ning last7 Berriz first7 Gabriel F. last8 Gibbons first8 Francis D. last9 ... author Baek K, Brown RS, Birrane G, Ladias JA title Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin dependent Kinase 9 journal J. Mol. Biol. volume 366 issue 2 pages 563 73 year ... more details
Image 2B9R.png thumb alt Structure of PDB 2B9R human cyclin B rendered with PyMol DeLano Scientific Freeware . Structure of human cyclin B. ref name pmid17495533 cite journal author Petri, E.T., Errico, A., Escobedo, L., Hunt, T., and Basavappa, R. title The crystal structure of human cyclin B journal Cell Cycle volume 11 issue 11 pages 1342 9 year 2007 pmid 17495533 ref protein Name cyclin B1 caption image width HGNCid 1579 Symbol cyclin B1 CCNB1 AltSymbols CCNB EntrezGene 891 OMIM 123836 RefSeq NM 031966 UniProt P14635 PDB ECnumber Chromosome 5 Arm q Band 12 LocusSupplementaryData protein Name cyclin B2 caption image width HGNCid 1580 Symbol cyclin B2 CCNB2 AltSymbols EntrezGene 9133 OMIM 602755 RefSeq NM 004701 UniProt O95067 PDB ECnumber Chromosome 15 Arm q Band 21.3 LocusSupplementaryData protein Name cyclin B3 caption image width HGNCid 18709 Symbol CCNB3 AltSymbols EntrezGene 85417 OMIM 300456 RefSeq NM 033670 UniProt Q8WWL7 PDB ECnumber Chromosome X Arm p Band 11 LocusSupplementaryData Cyclin B is a member of the cyclin family. Cyclin B is a mitosis mitotic cyclin. The amount of cyclin B which binds to Cdk1 and the activity of the cyclin B Cdk complex rise through the cell cycle ref name pmid11089869 cite journal author Ito M title Factors controlling cyclin B expression journal Plant Mol. Biol. volume 43 issue 5 6 pages 677 90 year 2000 month August pmid 11089869 doi 10.1023 A 1006336005587 url http www.kluweronline.com art.pdf?issn 0167 4412&volume 43&page 677 ref until mitosis, where they fall abruptly due to degradation of cyclin B Cdk1 is constitutively present ... of cyclin B journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. volume 354 issue 1389 pages 1571 ... url ref The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting ... the cell cycle . See also Cyclin B1 Cyclin B2 References Reflist External links MeshName Cyclin B http www.sdbonline.org fly newgene cyclinb1.htm Drosophila Cyclin B The Interactive Fly Cell cycle ... more details
D H year 1998 month Mar. title Identification of multiple cyclin subunits of human P TEFb journal ...PBB geneid 905 Cyclin T2 is a protein that in humans is encoded by the CCNT2 gene . ref name pmid9499409 cite journal author Peng J, Zhu Y, Milton JT, Price DH title Identification of multiple cyclin subunits ... Gene CCNT2 cyclin T2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p TEFb. The p TEFb complex containing this cyclin ..., have been described. ref name entrez cite web title Entrez Gene CCNT2 cyclin T2 url http www.ncbi.nlm.nih.gov ... Cyclin T2 has been shown to Protein protein interaction interact with CDK9 ref name pmid9499409 ... and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins ... cite journal author Kwak YT, Ivanov D, Guo J, et al. title Role of the human and murine cyclin T proteins in regulating HIV 1 tat activation. journal J. Mol. Biol. volume 288 issue 1 pages ... TA, Bogerd HP, Cullen BR title Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat cyclin T complexes. journal J. Virol. volume ... MA title The Cdk9 and cyclin T subunits of TAK P TEFb localize to splicing factor rich nuclear ... to and inhibits the activity of CDK9 cyclin T complexes. journal Nature volume 414 issue 6861 pages ... author Michels AA, Nguyen VT, Fraldi A, et al. title MAQ1 and 7SK RNA interact with CDK9 cyclin T complexes ... SA, Jedrychowski M, Schwartz D, et al. title Large scale characterization of HeLa cell nuclear ... BM title Transcriptional activity and substrate recognition of cyclin T2 from P TEFb. journal Gene ... is a novel partner of cyclin T2a in muscle differentiation. journal J. Cell. Physiol. volume 207 issue ... more details
PBB geneid 902 Cyclin H is a protein that in humans is encoded by the CCNH gene . ref name pmid9465303 ... title Mapping of the human genes encoding cyclin H CCNH and the CDK activating kinase CAK assembly factor ... cite web title Entrez Gene CCNH cyclin H url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized ... which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex ... kinases, thus functions as a CDK activating kinase CAK . This cyclin and its kinase partner are components ... control and the cell cycle machinery. ref name entrez Interactions Cyclin H has been shown to Protein ... laysource laydate quote ref Cyclin dependent kinase 7 ref name pmid8078587 cite journal last M kel ... 1994 month September title A cyclin associated with the CDK activating kinase MO15 journal Nature journal ... MAT1, a cyclin dependent kinase activating kinase CAK assembly factor journal Cancer Res. volume ... Linda, Robinson Mark D, O Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian ... month March title MTA1 interacts with MAT1, a cyclin dependent kinase activating kinase complex ring ... D title Transcriptional control Tat cofactors and transcriptional elongation journal Curr. Biol. volume ... Taviaux S display authors 3 last4 Fesquet first4 D last5 Martinez first5 AM last6 Galas first6 S last7 ... 0092 8674 94 90040 X cite journal author Fisher RP, Morgan DO title A novel cyclin associates ... pmid 8069918 doi 10.1016 0092 8674 94 90535 5 cite journal author M kel TP title A cyclin associated ... human CDK7 cyclin H complex requires MAT1, a novel 36 kDa RING finger protein journal EMBO J. volume ... EA cite journal author Adamczewski JP title MAT1, cdk7 and cyclin H form a kinase complex which is UV ... first6 D cite journal author Reardon JT title Isolation and characterization of two human transcription ... last6 Pan first6 ZQ cite journal author Drapkin R title Human cyclin dependent kinase activating kinase ... more details
PBB geneid 9133 G2 mitotic specific cyclin B2 is a protein that in humans is encoded by the CCNB2 gene . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Cyclin B2 is a member of the cyclin family, specifically the B type cyclins. The B type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2 cdc2 may play a key role in transforming growth factor beta mediated cell cycle control. ref name entrez cite web title Entrez Gene CCNB2 cyclin B2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9133 accessdate ref See also Cyclin B Interactions Cyclin B2 has been shown to Protein protein interaction interact with TGF beta receptor 2 . ref name pmid9926943 cite journal last Liu first J H authorlink coauthors Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y year 1999 month Jan. title Functional association of TGF beta receptor II with cyclin B journal Oncogene volume 18 issue 1 pages 269 75 publisher location ENGLAND issn 0950 9232 pmid 9926943 doi 10.1038 sj.onc.1202263 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref ... 11 pages 6705 11 year 1995 pmid 7474080 doi pmc 189580 cite journal author Re F, Braaten D, Franke ... the activation of p34cdc2 cyclin B. journal J. Virol. volume 69 issue 11 pages 6859 64 year 1995 ... localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. journal ... al. title Cyclin B2 null mice develop normally and are fertile whereas cyclin B1 null mice die in utero ... association of TGF beta receptor II with cyclin B. journal Oncogene volume 18 issue 1 pages ... more details
T J authorlink coauthors Peng J, Lee G, Price D H, Flores O year 1999 month December title Cyclin K ...PBB geneid 904 Cyclin T1 is a protein that in humans is encoded by the CCNT1 gene . ref name pmid9491887 ... C type cyclin interacts directly with HIV 1 Tat and mediates its high affinity, loop specific binding ..., Price DH title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev volume ... conserved cyclin family, whose members are characterized by a dramatic periodicity in protein ... of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p TEFb. The kinase complex containing this cyclin ... transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation ... cite web title Entrez Gene CCNT1 cyclin T1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 904 accessdate ref Interactions Cyclin T1 has been shown to Protein protein ... cyclin T complexes in a transcription dependent manner journal Mol. Cell. Biol. volume 23 issue 14 ... granulin interacts with cyclin T1 and modulates P TEFb dependent transcription journal Mol. Cell ... pmid9499409 cite journal last Peng first J authorlink coauthors Zhu Y, Milton J T, Price D H year 1998 month March title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev. volume ... year 2003 month September title The human I mfa domain containing protein, HIC, interacts with cyclin ... between cyclin T1 and SCF SKP2 targets CDK9 for ubiquitination and degradation by the proteasome ... year 2003 month May. title Recruitment of human cyclin T1 to nuclear bodies through direct interaction ... cite journal author Yankulov K, Bentley D title Transcriptional control Tat cofactors and transcriptional ... functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. journal ... year 2005 pmid 15638724 doi 10.2174 1570162052772924 cite journal author Gibellini D, Vitone F, Schiavone ... more details
PBB geneid 10309 Cyclin O is a protein that in humans is encoded by the CCNO gene . ref name entrez cite web title Entrez Gene CCNO cyclin O url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10309 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions Cyclin O has been shown to Protein protein interaction interact with RPA2 ref name pmid10393198 cite journal last Otterlei first M authorlink coauthors Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E year 1999 month Jul. title Post replicative base excision repair in replication foci journal EMBO J. volume 18 issue 13 pages 3834 44 publisher location ENGLAND issn 0261 4189 pmid 10393198 doi 10.1093 emboj 18.13.3834 bibcode oclc id url language format accessdate laysummary laysource laydate quote pmc 1171460 ref and PCNA . ref name pmid10393198 ref name pmid12171929 cite journal last Ohta first Satoshi authorlink coauthors Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki year 2002 month Oct. title A proteomics approach to identify proliferating cell nuclear antigen PCNA binding proteins in human cell lysates. Identification of the human CHL12 RFCs2 5 complex as a novel PCNA binding protein journal J. Biol. Chem. volume 277 issue 43 pages 40362 7 publisher location United States issn 0021 9258 pmid 12171929 ... title Cell cycle regulation of a human cyclin like gene encoding uracil DNA glycosylase journal J. Biol ... display authors 3 author1 Lu X author2 Bocangel D author3 Nannenga B author separator , last4 Yamaguchi ... S last7 Gordon first7 LA last8 Scott first8 D last9 Xie first9 G cite journal title The Status, Quality ... Rasooly first9 R pmc 528928 cite journal title The cyclin like uracil DNA glycosylase UDG of murine ... Miller D author separator , cite journal title Latency Associated Nuclear Antigen of Kaposi s Sarcoma ... more details
Unreferenced stub auto yes date December 2009 A cyclin dependent kinase complex abbreviated cdkc , also called cyclin CDK is a protein complex formed by the association of cyclin with cyclin dependent kinase . These complexes are able to phosphorylate other compounds under consumption of Adenosine triphosphate ATP , and are thereby involved in the regulation of the cell cycle . Depending on the type of cyclin attached to CDK, it has a different function. These serve as markers in each phase which are integral for the correct sequence of events, as well as facilitating the transition to the next phase. Classes Image Cyclinexpression waehrend Zellzyklus.png thumb 422px Expression of cyclins through the cell cycle . There are three classes of cdkc depending on the phase of the cell cycle. G1 phase G sub 1 sub phase cdkc, including mostly cyclinD and cyclin E DNA replication S phase cdkc mitosis M phase cdkc See also Cell cycle DEFAULTSORT Cyclin Dependent Kinase Complex Category Cell cycle Cell biology stub ... more details
class wikitable CDK Cyclin partner Function Deletion Phenotype in Mice Cdk1 Cyclin B M phase None. E2.5. Cdk2 Cyclin E G1 S transition Reduced size, imparted neural progenitor cell proliferation. Viable, but both males & females sterile. Cdk2 Cyclin A S phase, G2 phase Cdk3 Cyclin C G1 phase ? No defects. Viable, fertile. Cdk4 CyclinD G1 phase Reduced size, insulin deficient diabetes. Viable, but both ... after birth. Cdk6 CyclinD G1 phase Cdk7 Cyclin H CDK activating kinase, transcription Cdk8 Cyclin C Transcription Cdk9 Cyclin T Transcription Embryonic lethal Cdk11 Cyclin L ? Mitotic defects. E3.5. ? Cyclin F ? Defects in extraembryonic tissues. E10.5. ? Cyclin G ? CDKs and Cyclins in the Cell Cycle Most of the known cyclin CDK complexes regulate the progression through the cell cycle . Animal ... and the CDK of a complex and can be inhibitory or activating. Cip Kip proteins activate cyclinD ... of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent ... domain. ref name Morgan2007 By definition, a CDK binds a regulatory protein called a cyclin . Without cyclin , CDK has little kinase activity only the cyclin CDK complex is an active kinase ..., their cyclin partners, and their functions in the human ref name Morgan1997 and consequences of deletion ... cycle regulation. ref name Morgan2007 In mammalian cells, CDK1, with its partners cyclin A2 and B1, alone ... as the CDK activating kinase. ref name Morgan2007 Cyclin CDK complexes phosphorylate substrates appropriate for the particular cell cycle phase. ref name Morgan1997 Cyclin CDK complexes in earlier cell cycle phase help activate cyclin CDK complexes in later phases. ref name Morgan2007 Table 2 Cyclins and CDKs by Cell Cycle Phase class wikitable Phase Cyclin CDK G0 C Cdk3 G1 D, E Cdk4, Cdk2, Cdk6 S A, E Cdk2 G2 A Cdk2, Cdk1 M B Cdk1 Table 3 Cyclin dependent kinases that control the cell cycle in model ... protein, cyclin or other. CDK1 cyclin A , cyclin B Cyclin dependent kinase 2 CDK2 cyclin ... more details
Entrez Gene CDK6 cyclin dependent kinase 6 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1021 accessdate ref It is regulated by CyclinD . The PBB Summary template ... activity for cdk6, a novel cyclinD partner journal Mol. Cell. Biol. volume 14 issue 3 pages 2077 ... cyclinD associated cdk4 homologue in normal human T lymphocytes journal J. Immunol. volume 154 issue ... of G1 kinase activity for cdk6, a novel cyclinD partner journal Mol. Cell. Biol. volume ..., et al. title Hypo phosphorylation of the retinoblastoma protein pRb by cyclinD Cdk4 6 complexes ... TL, Fox TR title Chemical transformation of mouse liver cells results in altered cyclinD CDK protein ... DH, Dhanaraj V, Wick S, et al. title Crystal structure of the complex of the cyclinD dependent ... Summary section title summary text The protein encoded by this gene is a member of the cyclin dependent kinase cyclin dependent protein kinase CDK family. CDK family members are highly similar to the gene ... including D type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4 ... name entrez Interactions Cyclin dependent kinase 6 has been shown to Protein protein interaction interact ... D, O Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang ... cite journal last Jeffrey first P D authorlink coauthors Tong L, Pavletich N P year 2000 month December title Structural basis of inhibition of CDK cyclin complexes by INK4 inhibitors journal Genes ... coauthors Paramio J M, Ball K L, La n S, Lane D P year 1996 month January title Inhibition of pRb ... Tong L, Lee J O, Jeffrey P D, Pavletich N P year 1998 month September title Structural basis for inhibition of the cyclin dependent kinase Cdk6 by the tumour suppressor p16INK4a journal Nature journal ... T P, Solomon M J year 2001 month December title CAK independent activation of CDK6 by a viral cyclin ... Kaldis P, Solomon M J year 2000 month November title Dephosphorylation of human cyclin dependent ... more details
PBB geneid 1025 Cyclin dependent kinase 9 or CDK9 is a cyclin dependent kinase associated with P TEFb ... of the cyclin dependent protein kinase CDK family. CDK family members are highly similar to the gene ... by its regulatory subunit cyclin T or cyclin K. HIV 1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. ref cite web title Entrez Gene CDK9 cyclin dependent kinase 9 CDC2 related kinase url http www.ncbi.nlm.nih.gov ... been shown to Protein protein interaction interact with Cyclin K , ref name pmid10574912 cite journal last Fu first T J authorlink coauthors Peng J, Lee G, Price D H, Flores O year 1999 month December title Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription ... quote doi 10.1074 jbc.274.49.34527 ref Cyclin T2 , ref name pmid9499409 cite journal last Peng first J authorlink coauthors Zhu Y, Milton J T, Price D H year 1998 month March title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev. volume 12 issue 5 pages 755 62 publisher ... ref Cyclin T1 , ref name pmid10574912 ref name pmid9499409 ref name pmid15107825 cite journal last Cabart ... with cyclin T1 and modulates P TEFb dependent transcription journal Mol. Cell. Biol. volume ..., Bensaude Olivier year 2003 month July title MAQ1 and 7SK RNA interact with CDK9 cyclin T complexes ... interacts with cyclin T1 and modulates P TEFb dependent transcription journal Mol. Cell. Biol ... December title Interaction between cyclin T1 and SCF SKP2 targets CDK9 for ubiquitination and degradation ... receptor , ref name pmid11266437 cite journal last Lee first D K authorlink coauthors Duan H O ... K, Bentley D title Transcriptional control Tat cofactors and transcriptional elongation. journal ... 1 cite journal author Romano G, Kasten M, De Falco G, et al. title Regulatory functions of Cdk9 and of cyclin ... 10.2174 1570162052772924 cite journal author Gibellini D, Vitone F, Schiavone P, Re MC title HIV ... more details
gene . ref name pmid8069918 cite journal author Fisher RP, Morgan DO title A novel cyclin associates ... is a member of the Cyclin dependent kinase cyclin dependent protein kinase CDK family. CDK ... forms a trimeric complex with cyclin H and MAT1 , which functions as a Cdk activating kinase ... of transcription and the cell cycle. ref name entrez cite web title Entrez Gene CDK7 cyclin ... sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1022 accessdate ref Interactions Cyclin dependent ... human MAT1, a cyclin dependent kinase activating kinase CAK assembly factor journal Cancer Res ... oclc id url language format accessdate laysummary laysource laydate quote ref Cyclin H , ref name ... J P, Nigg E A, Frutiger S, Hughes G J, Weinberg R A year 1994 month September title A cyclin associated ... is phosphorylated by CDK7 cyclin H in a p36MAT1 dependent manner journal Mol. Cell. Biol. volume ... pmid10734072 cite journal last Lee first D K authorlink coauthors Duan H O, Chang C year 2000 month ... H C, Morgan D O, Reinberg D year 1995 month March title Cdk activating kinase complex is a component ... year 2003 month March title MTA1 interacts with MAT1, a cyclin dependent kinase activating kinase ... laydate quote ref and SUPT5H . ref name pmid10958691 See also Cyclin dependent kinase CDK7 pathway ... 1 pages 24 7 year 1998 pmid 9570510 doi 10.1007 BF02253352 cite journal author Yankulov K, Bentley D ... families of cyclin dependent kinase CDK inhibitors block the phosphorylation of cyclin dependent ..., et al. title A cyclin associated with the CDK activating kinase MO15 journal Nature volume 371 issue ... L, Yee A, Liu L, et al. title Molecular cloning of the human CAK1 gene encoding a cyclin dependent kinase ... MAT1, a cyclin dependent kinase activating kinase CAK assembly factor journal Cancer Res. volume 55 ... author Drapkin R, Le Roy G, Cho H, et al. title Human cyclin dependent kinase activating kinase exists ... year 1996 pmid 8934526 doi 10.1038 384375a0 cite journal author Garc a Mart nez LF, Ivanov D, Gaynor ... more details
by this gene is part of the cyclin dependent kinase family. Physiological Role Recently Cdk5 has ... other cyclin dependent kinases, CDK5 does not also require phosphorylation on the T loop so that binding ... T, Ogawa M, Mikoshiba K title Modulation of Reelin signaling by Cyclin dependent kinase 5 journal ... by cyclin dependent kinase 5 via phosphorylation of Munc18 journal J Biol Chem volume 274 issue ... cite journal author Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ title Cyclin dependent kinase 5 activity is required for T cell activation and induction ... map NicotineDopaminergicActivity WP1602 highlight Cyclin dependent kinase 5 Interactions Cyclin ..., Banner Steven J, Shemilt Stephen J A, Cooper Jonathan D, Leigh P Nigel, Shaw Christopher E, McLoughlin ... associated neuronal kinase, cyclin dependent kinase 5 p35 regulated kinase journal J. Neurosci. volume ... , ref name pmid11163260 cite journal last Niethammer first M authorlink coauthors Smith D S, Ayala ... 2001 month June title Expression of the neuronal cyclin dependent kinase 5 activator p35Nck5a in human ... J, Kesavapany S, Agarwal N, Kuner R, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB 2007 Cyclin dependent ... S, Pant HC, Iadarola MJ, Brady RO, Kulkarni AB 2006 Cyclin dependent kinase 5 activity regulates ... links MeshName Cyclin Dependent Kinase 5 Cell cycle proteins PBB Controls update page yes require ... Cyclin dependent kinase 05 Category Cell cycle Category Proteins gene 7 stub ru ... more details
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