- Cyclopamine
Section3 Chembox Hazards MainHazards FlashPt Autoignition Cyclopamine 11 deoxojervine is a naturally ... of a single eye cyclopia . It does so by inhibiting the hedgehog signaling pathway Hh . Cyclopamine ... cancers in which Hh is overexpressed. Cyclopamine was named for one eyed lambs which were born ... started an eleven year investigation which led to the identification of cyclopamine as the cause of the birth ... effects Cyclopamine inhibits the hedgehog signaling pathway Hh by influencing the balance between the active and inactive forms of the smoothened protein. Medical potential Cyclopamine is currently ... mutations in Smoothened and Patched can be reversed by cyclopamine journal Nature journal Nature date ... Matthew P. ref glioblastoma , and as a treatment agent for multiple myeloma . Studies suggest that cyclopamine ..., pancreatic and breast cancers. A way of controlling the pathway using cyclopamine could turn ... Base date 2009 08 15 author David Bradley ref The cyclopamine derivative chemistry derivative IPI ... ref See also Saridegib also know as IPI 926 , a semi synthetic analog of cyclopamine, a natural ... first1 S last2 Avci first2 O title Rapid clearance of psoriatic skin lesions induced by topical cyclopamine ... Kim first6 YK last7 Chang first7 CW title Synthesis and anticancer activity studies of cyclopamine ... more details
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- Testis cords
Infobox Embryology Name PAGENAME Latin GraySubject GrayPage Image Caption Image2 Caption2 System CarnegieStage Days 49 Precursor sex cord GivesRiseTo rete testis MeshName MeshNumber DorlandsPre c 55 DorlandsSuf 12259039 The testis cords are precursors to the rete testis . They play several different roles in the development of the male genitals. ref name pmid12051821 cite journal author Yao HH, Capel B title Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis journal Dev. Biol. volume 246 issue 2 pages 356 65 year 2002 pmid 12051821 doi 10.1006 dbio.2002.0663 ref References reflist Development of urinary and reproductive systems Category Embryology of urogenital system developmental biology stub ... more details
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- Ciclopramine
Distinguish cyclopamine Drugbox IUPAC name N methyl 2,3,7,8 tetrahydro 1 H quino 1,8 ab 1 benzazepin 3 amine image Ciclopramine.png Clinical data tradename pregnancy category legal status Not marketed routes of administration Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 33545 56 1 ATC prefix None ATC suffix PubChem 160410 ChemSpiderID 140965 UNII Ref fdacite correct FDA UNII BXS8X8APGS Chemical data C 18 H 20 N 2 molecular weight 264.36 g mol smiles c14c2c ccc1 C NC CCN2c3ccccc3CC4 Ciclopramine is a tetracyclic antidepressant TeCA that was never marketed. ref name isbn0 412 46630 9 cite book author David J. Triggle title Dictionary of pharmacological agents publisher Chapman & Hall location London year 1997 pages isbn 0 412 46630 9 oclc doi accessdate ref ref name pmid7090895 cite journal author Saletu B title Pharmaco EEG profiles of typical and atypical antidepressants journal Advances in Biochemical Psychopharmacology volume 32 issue pages 257 68 year 1982 pmid 7090895 doi url ref References Reflist Antidepressants Tricyclics Category Amines Category Tetracyclic antidepressants Category Dibenzazepines nervous system drug stub ... more details
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- Jervine
binding of Cyclopamine to Smoothened journal Genes Dev. year 2002 volume 16 pages 2743 2748 ... more details
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- Veratrum californicum
effects It is a source of jervine and cyclopamine , teratogen s which can cause prolonged ..., J Taipale, J Cooper, M. title Inhibition of Hedgehog Signaling by direct binding of Cyclopamine ... Cyclopamine extracted from V. californicum is being used in anti cancer experimental drugs. One ... more details
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- Vismodegib
media media releases med cor 2012 01 30.htm ref Mechanism of action The substance acts as a cyclopamine ... in more than 90 of basal cell carcinomas. ref name Spreitzer See also Cyclopamine , a naturally ... more details
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- Veratrum
. Cyclopamine derived from Veratrum species is a potent teratogen that is an effective treatment for several ... in Smoothened and Patched can be reversed by cyclopamine journal Nature journal Nature date 2000 08 ... more details
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- IPI-926
ref Chemically, it is a semi synthetic derivative chemistry derivative of the alkaloid cyclopamine . The process begins with cyclopamine extracted from harvested Veratrum californicum which is taken through a series of alterations resulting in an analogue of the natural product cyclopamine, making ... more details
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- Fermentek
, cyclopamine , Thiostrepton , Staurosporine , Mithramycin , Midostaurin , Geldanamycin and its derivates ... more details
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- Smoothened
differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling journal ... more details
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- Cyclopia
teratogenic alkaloid toxin that can cause cyclopia is cyclopamine or 2 deoxyjervine, found in the plant ... more details
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- Small molecule
medium media anti shh antibodies , HHIP Hedgehog interacting protein or cyclopamine , the first ... more details
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- List of biomolecules
This is a list of articles that describe particular biomolecule s or types of biomolecules. compactTOC8 side yes seealso yes nobreak yes A For substances with an A or prefix such as a amylase amylase , please see the parent page in this case Amylase . A23187 Calcimycin, Calcium Ionophore Abamectin Abietic acid Acetic acid Acetylcholine Actin Actinomycin D Adenosine Adenosine diphosphate ADP Adenosine monophosphate AMP Adenosine triphosphate ATP Adenylate cyclase Adonitol Adrenaline , epinephrine Adrenocorticotropic hormone ACTH Aequorin Aflatoxin Agar Alamethicin Alanine Albumins Aldosterone Aleurone Alpha amanitin Allantoin Allethrin Amanatin, see Alpha amanitin Amino acid Amylase also see a amylase amylase Anabolic steroid Anethole Angiotensinogen Anisomycin Antidiuretic hormone ADH Arabinose Arginine Ascomycin Ascorbic acid vitamin C Asparagine Aspartic acid Asymmetric dimethylarginine Atrial natriuretic peptide ANP Auxin Avidin Azadirachtin A &ndash C sub 35 sub H sub 44 sub O sub 16 sub B Bacteriocin Beauvericin Bicuculline Bilirubin Biopolymer Biotin Vitamin H Brefeldin A Brassinolide Brucine C Cadaverine Caffeine Calciferol Vitamin D calcitonin Calmodulin Calmodulin Calreticulin Camphor Cannabinol Capsaicin Carbohydrase Carbohydrate Carnitine Carrageenan Casein Caspase Cellulase Cellulose C sub 6 sub H sub 10 sub O sub 5 sub sub x sub Cerulenin Cetrimonium bromide Cetrimide C sub 19 sub H sub 42 sub BrN Chelerythrine Chromomycin A3 Chaparonin Chitin a chloralose Chloralose Chlorophyll Cholecystokinin CCK Cholesterol Choline Chondroitin sulfate Cinnamaldehyde Citral Citric acid Citrinin Citronellal Citronellol Citrulline Cobalamin Vitamin B12 vitamin B sub 12 sub Coenzyme Coenzyme Q Colchicine Collagen Coniine Corticosteroid Corticosterone Corticotropin releasing hormone CRH Cortisol Creatine Creatine kinase Crystallin Alpha cyclodextrin Cyclodextrin Cyclodextrin glycosyltransferase Cyclopamine Cyclopiazonic acid Cysteine Cystine Cytidine Cytochala ... more details
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- Veratrum nigrum
name Barecloux815 ref name Huang246 Cyclopamine 11 deoxojervine is one of the alkaloids isolated from the plant which interferes with the hedgehog signaling pathway Hh . Cyclopamine is under investigation ... more details
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- Hedgehog signaling pathway
severe defects of holoprosencephaly , results if the pathway inhibitor cyclopamine is consumed by gestating mammals. ref cite journal doi 10.1007 BF02533750 title Cyclopamine and related steroidal alkaloid ... SMO targeting agents are cyclopamine competitive. Itraconazole Sporanox has also been shown to target SMO through a mechanism distinct from cyclopamine and vismodegib . ref cite journal doi 10.1016 ... of Hh signaling Cyclopamine , a naturally occurring small molecule Vismodegib , an investigational ... more details
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- Cyclops
. 3.80 83, Ep. ad Pis. 300 . ref contains the alkaloids cyclopamine and jervine , which are teratogen ... more details
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- Psoriasis
Infobox disease Name Psoriasis Image Psoriasis on back1.jpg Caption A person whose back and arms are affected by psoriasis DiseasesDB 10895 ICD10 ICD10 L 40 l 40 ICD9 ICD9 696 ICDO OMIM 177900 MedlinePlus 000434 eMedicineSubj emerg eMedicineTopic 489 eMedicine mult Dermatology eMedicine2 derm 365 plaque br eMedicine2 derm 361 guttate br eMedicine2 derm 363 nails br eMedicine2 derm 366 pustular br Arthritis eMedicine2 derm 918 br Radiology eMedicine2 radio 578 br Physical Medicine eMedicine2 pmr 120 MeshID D011565 Psoriasis IPAc en icon s r a . s s is an autoimmune disease that appears on the skin. It occurs when the immune system mistakes the skin cells as a pathogen, and sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis is not contagious. ref cite web title Learn About psoriasis publisher National Psoriasis Foundation url http www.psoriasis.org netcommunity about psoriasis ref However, psoriasis has been linked to an increased risk of stroke, ref cite news title Psoriasis Linked to Stroke Risk publisher BBC url http www.bbc.co.uk news health 14559523 date 28 August 2011 ref and treating high Blood lipids blood lipid levels may lead to improvement. ref cite pmid 21233693 ref There are five types of psoriasis plaque, guttate, inverse, pustular and erythrodermic. The most common form, plaque psoriasis, is commonly seen as red and white hues of scaly patches appearing on the top first layer of the epidermis skin . Some patients, though, have no dermatological symptoms. In plaque psoriasis, skin rapidly accumulates at these sites, which gives it a silvery white appearance. Plaques frequently occur on the skin of the Elbow joint elbows and knee s, but can affect any area, including the scalp , palms of hands and soles of feet, and sex organ genitals . In contrast to eczema , psoriasis is more likely to be found on the extensor outer side of the joint. The disease disorder is a chronic recurring condition that varies in severi ... more details
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- Cancer stem cell
, such as cyclopamine . There is also a new water soluble cyclopamine that may be more effective in cancer ... more details
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- Alkaloid
cyclopamine present in the plant. Most alkaloids contain oxygen those compounds are usually colorless ... them. A characteristic example is the alkaloid cyclopamine , which is present in the leaves of Veratrum ... as the alkaloid 11 deoxyjervine, which was renamed cyclopamine. ref cite book page 362 ... more details
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- Hellebore
s cyclopamine and jervine , it is believed to be the hellebore used by Hippocrates ... more details
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- Mir-92 microRNA precursor family
cyclopamine drug was sufficient to reduce proliferation of tumour cells that had been infected ... more details
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