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Encyclopedia results for Cystic fibrosis transmembrane conductance regulator

Cystic fibrosis transmembrane conductance regulator





Encyclopedia results for Cystic fibrosis transmembrane conductance regulator

  1. Cystic fibrosis transmembrane conductance regulator

    PBB geneid 1080 Cystic fibrosis transmembrane conductance regulator CFTR is a protein ref name pmid16554808 ... SL title An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton ... April pmid 1320177 doi url issn ref Interactions Cystic fibrosis transmembrane conductance regulator ... and associates with cystic fibrosis transmembrane conductance regulator interacting PDZ proteins ... month December title The cystic fibrosis transmembrane conductance regulator interacts with and regulates ... RF PDZ1 domain matches the C terminal sequence of cystic fibrosis transmembrane conductance regulator ..., P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na ... in the cystic fibrosis transmembrane conductance regulator CFTR gene a report from the Cystic ... transmembrane conductance regulator and the etiology and pathogenesis of cystic fibrosis journal ... domains on cystic fibrosis transmembrane conductance regulator journal Biochim. Biophys. Acta ... doi cite journal author Schwartz M title Cystic fibrosis transmembrane conductance regulator ... between cystic fibrosis transmembrane conductance regulator, extracellular nucleotides and cystic ... cftr.php The Cystic Fibrosis Transmembrane Conductance Regulator Protein http archive.uwcm.ac.uk ... Cystic Fibrosis Transmembrane Conductance Regulator Category ABC transporters Category Mutated genes ca CFTR de Cystic Fibrosis Transmembrane Conductance Regulator fr G ne et prot ine CFTR hu CFTR pl CFTR ru sk Cystic fibrosis transmembrane conductance ... title A Golgi associated PDZ domain protein modulates cystic fibrosis transmembrane regulator ... June title Protein kinase C epsilon dependent regulation of cystic fibrosis transmembrane regulator ... 1998 month July title An apical PDZ protein anchors the cystic fibrosis transmembrane conductance ... fibrosis transmembrane conductance regulator in airway cells journal J. Biol. Chem. volume ...   more details



  1. Cystic fibrosis

    by a mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator ... transmembrane conductance regulator CFTR . The most common mutation, F508 , is a deletion of three ... transmembrane conductance regulator to the cytoskeleton journal J. Biol. Chem. volume 273 issue ...Infobox disease Name Cystic fibrosis Image CFtreatmentvest2.JPG Alt Caption A breathing treatment for cystic ... GeneReviewsID GeneReviewsName Cystic fibrosis also known as CF or mucoviscidosis is an autosomal ... to thick, viscous secretions. ref name yankas cite journal title Cystic fibrosis adult care ... 39 pmid 14734689 doi 10.1378 chest.125.1 suppl.1S issue 90010 ref The name cystic fibrosis refers to the characteristic ... . ref name andersen Andersen DH. Cystic fibrosis of the pancreas and its relation to celiac ... of the CFTR gene, only one is needed to prevent cystic fibrosis due to the disorder s recessive ... G Cystic fibrosis. Lancet. 2003 Feb 22 361 9358 681 9. ref ref http www.patient.co.uk doctor Cystic Fibrosis.htm Patient UK website Cystic Fibrosis ref The World Health Organization states that In the European ... public geneticdiseases en index2.html ref Individuals with cystic fibrosis can be diagnosed before ... is often necessary as CF worsens. Signs and symptoms File Cystic fibrosis manifestations.png 400px thumb right A diagram showing clinical manifestations of cystic fibrosis ref name isbn0 8089 2325 ... pages quote isbn 0 8089 2325 0 oclc doi url accessdate ref The hallmark symptoms of cystic fibrosis are salty tasting skin , ref name pmid17557942 cite journal author Quinton PM title Cystic fibrosis ... with cystic fibrosis a review of published studies journal Eur. J. Endocrinol. volume 151 Suppl .... ref name pmid19393108 cite journal author O Malley CA title Infection control in cystic fibrosis cohorting ... contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis journal ... cite journal author Ratjen FA title Cystic fibrosis pathogenesis and future treatment strategies ...   more details



  1. Cystic Fibrosis Canada

    Infobox non profit name Cystic Fibrosis Canada image File Cystic Fibrosis Canada 2011.png 160px The new logo and name Cystic Fibrosis Canada , 2011 onward. type Health Charity founded date start date 1960 ... 2009 Keeping a Promise accessdate 2010 12 21 date 2009 publisher Cystic Fibrosis Canada ref endowment ... life into the future former name homepage URL cysticfibrosis.ca dissolved footnotes Cystic Fibrosis Canada , formerly the Canadian Cystic Fibrosis Foundation, is a Canada wide health Charitable organization ..., Cystic Fibrosis Canada celebrated its 50th Anniversary. Cystic Fibrosis Canada s mandate is to help individuals with cystic fibrosis , principally by funding cystic fibrosis research and care. The organization also provides educational materials for the cystic fibrosis community and the general public undertakes advocacy initiatives with, and on behalf of Canadians with cystic fibrosis, and raises funds to supports its programs. Cystic Fibrosis Canada is one of the world s largest non governmental granting agencies in the field of cystic fibrosis research. ref cite web url http www.cysticfibrosis.ca en research index.php title Cystic Fibrosis Canada Research accessdate 2011 01 31 date 2010 05 19 publisher Cystic Fibrosis Canada ref Mission Cystic Fibrosis Canada raises funds in order to promote public awareness and support research and high quality cystic fibrosis care. ref cite web url http www.cysticfibrosis.ca en aboutUs mission.php title Cystic Fibrosis Canada About us What we do Mission accessdate 2011 01 31 date 2009 08 06 publisher Cystic Fibrosis Canada ref Research and Care Cystic Fibrosis Canada s primary objective is to fund CF research and care the organization annually ... undertaking CF investigations. Each year, Cystic Fibrosis Canada awards more than 6 million in grants ... title Cystic Fibrosis Canada Research accessdate 2011 01 31 date 2010 05 19 publisher Cystic Fibrosis Canada ref To help ensure consistent, high quality care across the country, Cystic Fibrosis Canada ...   more details



  1. Cystic Fibrosis Trust

    The Cystic Fibrosis Trust , founded in 1964, is the United Kingdom s only national charity dedicated to all aspects of cystic fibrosis CF . It funds research to treat and cure CF and aims to ensure appropriate clinical care and support for people with cystic fibrosis. Objectives Its objectives are To fund medical and scientific research provide effective treatments and develop a cure for cystic fibrosis To ensure appropriate clinical care for those with cystic fibrosis To provide information, advice, support and, where appropriate, financial assistance to anyone affected by cystic fibrosis Research The aim of the Cystic Fibrosis Trust research is to understand, treat and cure cystic fibrosis. The Cystic Fibrosis Trust is the major funder of medical and scientific CF research in the UK. The Trust ... future. Gene therapy aims to add a healthy copy of the faulty CF gene to the lung. The Cystic Fibrosis ... through the UK Cystic Fibrosis Gene Therapy Consortium . ref http cfgenetherapy.org.uk UK Cystic ... with cystic fibrosis. Clinical care Cystic fibrosis is a complex disease requiring considerable specialist ... CF treatment centres throughout the UK. Since 1997, the Cystic Fibrosis Trust has invested over 10 ... of tomorrow. The Cystic Fibrosis Trust sets national standard on clinical care, provides and funds ... of those with CF across the UK. Information, advice and support The Cystic Fibrosis Trust provides a confidential ..., schools and employers and anyone interested in cystic fibrosis. The Trust also advise families on benefits ... sales will go to the Cystic Fibrosis Trust while the exhibition describes the recessive gene inheritance pattern that causes ginger, or red, hair the same inheritance pattern that causes cystic fibrosis ... See also List of cystic fibrosis organizations Cystic Fibrosis Foundation Canadian Cystic Fibrosis Foundation References Reflist External links http www.cftrust.org.uk The Cystic Fibrosis Trust http cfgenetherapy.org.uk UK Cystic Fibrosis Gene Therapy Consortium Category Health charities in the United ...   more details



  1. Cystic Fibrosis Foundation

    Infobox Non profit Non profit name Cystic Fibrosis Foundation Non profit logo Image Cystic Fibrosis Foundation logo.png founded date 1955 founder location Bethesda, Maryland origins key people Robert J. Beall, Ph.D., President and CEO area served USA focus Cystic fibrosis method revenue United States dollar US 143.7 1000000 number million 2005 ref name 2005 financial cite web url http www.charitynavigator.org index.cfm bay search.summary orgid 9142.htm title Charity Navigator Rating Cystic Fibrosis Foundation publisher Charity Navigator accessdate 2007 10 02 ref endowment num employees owner Non profit slogan homepage http www.cff.org cff.org The Cystic Fibrosis Foundation CFF is a non profit organization in the United States established to provide the means to cure and control cystic fibrosis CF . The Foundation provides information about cystic fibrosis and finances CF research that aims to improve the quality of life for people with the disease. The Foundation also engages in legislative lobbying for cystic fibrosis. ref name about cite web url http www.cff.org aboutCFFoundation title About the Cystic Fibrosis Foundation publisher Cystic Fibrosis Foundation accessdate 2007 10 02 ... . In addition to providing Grant money grants for research into cystic fibrosis and supporting ... with cystic fibrosis. The Foundation has over 80 chapters and offices across the US. In 1989, scientists working for the Foundation discovered the gene that causes cystic fibrosis, considered ... of cystic fibrosis organizations Canadian Cystic Fibrosis Foundation Cystic Fibrosis Trust Association Gr gory Lemarchal NACFC References Reflist External links http www.cff.org Cystic Fibrosis Foundation http www.medicalnewstoday.com medicalnews.php?newsid 19241 Cystic Fibrosis Foundation Marks 50 Years in the Fight Against Cystic Fibrosis Category Charities based in the United States US philanthropy org stub fr Cystic Fibrosis Foundation tr Kistik Fibrozis Kurumu ...   more details



  1. Cystic fibrosis-related diabetes

    Wikify date December 2011 For general diabetes discussion Diabetes Infobox disease Name Cystic fibrosis related diabetes Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic eMedicine mult MeshID Cystic fibrosis related diabetes CFRD is diabetes specifically caused by cystic fibrosis , a genetic condition. Cystic fibrosis related diabetes mellitus CFRD develops with age, and the median age at diagnosis is 21 years. ref name pmid20034372 cite journal author Lek N, Acerini CL title Cystic fibrosis related diabetes mellitus diagnostic and management challenges. journal Curr Diabetes Rev year 2010 volume 6 issue 1 pages 9 16 pmid 20034372 doi pmc url http www.ncbi.nlm.nih.gov entrez eutils elink.fcgi?dbfrom pubmed&tool sumsearch.org cite&retmode ref&cmd prlinks&id 20034372 ref See also Diabetes Diabetes mellitus Cystic fibrosis References references External links http www.cff.org LivingWithCF StayingHealthy Diet Diabetes Cystic Fibrosis Foundation, Guide to Cystic Fibrosis Related Diabetes Category Diabetes Category Pulmonology Category Endocrinology ...   more details



  1. List of cystic fibrosis organizations

    The following organizations assist people with or do research into cystic fibrosis , a hereditary disease .... Australia Cystic Fibrosis Australia ref http www.cysticfibrosis.org.au Cystic Fibrosis Australia ref CFA , an Australian national organization aimed at raising awareness and education of cystic fibrosis ... others and search members. It is created by the CF community for the CF community. Cystic Fibrosis ... fibrosis European Cystic Fibrosis Society ref http www.ecfsoc.org European Cystic Fibrosis ... to information outreach and research for cystic fibrosis, named after the French singer and Star Academy France Star Academy winner Gr gory Lemarchal http www.ncfs.nl Nederlandse Cystic Fibrosis ... Fund ref a U.K based foundation to help support families and their children with cystic fibrosis. Cystic ... and support specific to cystic fibrosis. Operating since 1994, Cystic L serves people with CF ..., spouses, siblings, friends and significant others. Cystic Fibrosis Canada http www.cysticfibrosis.ca CCFF , a Canada wide health charity, which funds cystic fibrosis research and care. Cystic Fibrosis ... fibrosis Cystic Fibrosis Lifestyle Foundation ref http www.cflf.org index.php Cystic Fibrosis Lifestyle ... that engage adolescents and young adults with Cystic Fibrosis as active agents in their healthcare ... and longer lives for themselves. Founded by Brian Callanan. Cystic Fibrosis Reaching Out Foundation , ref http www.reachingoutfoundation.org Cystic Fibrosis Reaching Out Foundation ref a US based ... , a United States US based organization supporting research aimed at finding a cure for cystic fibrosis as well providing education and raising quality of life for people with cystic fibrosis, named ..., named after scientist Elizabeth Nash National Cystic Fibrosis Awareness Committee ref http www.cfawareness.org National Cystic Fibrosis Awareness Committee ref NCFAC , a US based group focused on increased public CF awareness through an annual national Cystic Fibrosis Awareness observance Rock ...   more details



  1. Cystic Fibrosis Foundation Slovenia

    Primary sources date January 2010 The Cystic Fibrosis Foundation from Slovenia Slovene Dru tvo za cisti no fibrozo Slovenije is a non profit organization in Slovenia , Europe. The foundation is a member of the European Cystic Fibrosis Society ECFS and Cystic Fibrosis Europe CFE , a section of international CF organization Cystic Fibrosis Worldwide CFW . History The foundation was established on 3 November 2009. Before it was a part of http www.dpbs.si Association of pulmonary and allergic patients in Slovenia Slovene Dru tvo plju nih in alergijskih bolnikov Slovenije Goals The purpose of association is organized to assist all patients affected with cystic fibrosis and their families to achieve the highest possible quality of life that contribute to a better and longer life of patients affected with cystic fibrosis. The society is intended to address and alleviate social distress and difficulties of people, providing assistance to people whose health or life is threatened, and the strengthening of public health. One of goals is also to educate inform the Slovenian people and general public about the CF and various aspects of life of patients affected with it. See also List of cystic fibrosis organizations References http www.jana.si aktualno ljudje Njen boj za zivljenje.html Her fight ... a delegation of the Cystic Fibrosis Foundation in Slovenia , 2009 http www.primorski.eu stories ... to highlight the problems of patients with cystic fibrosis , newspaper Primorski dnevnik, 2009 http www.dnevnik.si novice zdravje 1042313407 The first European Week of awareness of the cystic fibrosis ... in CF External links http www.drustvocf.com Official webpage of Cystic fibrosis Foundation from Slovenia http www.dpbs.si Dru tvo plju nih in alergijskih bolnikov Slovenije http www.cfww.org Cystic Fibrosis Worldwide CFW http www.ecfs.eu European Cystic Fibrosis Society ECFS http www.cff.org Cystic Fibrosis Foundation Category Charitable organizations Category Slovenian associations hr Dru tvo za ...   more details



  1. List of people diagnosed with cystic fibrosis

    The following notable people have or had cystic fibrosis . Note Please cite sources when adding entries to this list, non sourced entries will be removed class wikitable width 17 Name width 10 Life width 68 Comments width 5 Reference valign top Frankie Abernathy 1981 2007 Former cast member of MTVs The Real World San Diego appeared in 22 of the 25 episodes. ref cite web date June 12, 2007 url http www.mtv.com news articles 1562302 20070612 id 0.jhtml title Real World San Diego Alum Frankie Abernathy Dead At 25 publisher MTV accessdate 2007 06 12 ref valign top Dean Barnett 1967 2008 American conservative columnist and blogger. ref cite web date October 27, 2008 url http www.boston.com bostonglobe regional editions globe west west 2008 10 dean barnett a.html title Dean Barnett, conservative blogger, dead at 41 publisher Boston Globe accessdate 2008 10 27 ref valign top Lisa Bentley 1968 Canadian Ironman triathlete. ref cite web date July 7, 2004 url http www.cysticfibrosis.ca page.asp?id 237 title Lisa Bentley Triumphs Over CF publisher Canadian Cystic Fibrosis Foundation accessdate 2007 01 26 ref valign top Fraser Brown 2006 Son of former UK Prime Minister Gordon Brown . ref cite news date November 29, 2006 url http www.timesonline.co.uk article 0,,2 2478775,00.html title Gordon Brown s baby son diagnosed with cystic fibrosis publisher Times Online accessdate 2007 01 26 location ... scientists have suggested that his symptoms were more consistent with cystic fibrosis, unknown at the time ... Children s Book Author, Actor, Cystic Fibrosis advocate, CEO President Travis Flores Children s Foundation www.tfcf.org valign top Boomer Esiason The Fight Against Cystic Fibrosis Gunnar Esiason 1991 ... 02 23 ref References reflist Category Lists of people by medical condition Cystic fibrosis ... 2F03 2F08 2Fnalice08.xml first Becky last Barrow title Pop singer dies after valiant battle with cystic fibrosis work Telegraph date 2003 07 03 accessdate 2007 02 23 location London ref valign top ...   more details



  1. Conductance

    wiktionary conductance Conductance may refer to Electrical conductance , the ability for electricity to flow a certain path Fluid conductance , the ability for fluid to transmit through materials Thermal conductivity , the ability for temperatures to transmit through materials Conductance graph , a measure in graph theory See also Conductivity disambiguation disambig ca Resist ncia el ctrica da Konduktans fr Conductance pt Condut ncia ...   more details



  1. Fibrosis

    ref improve date October 2011 cleanup date November 2009 Infobox Disease Name Fibrosis Image Cardiac amyloidosis very high mag movat.jpg Caption Micrograph of a heart showing fibrosis yellow left of image and amyloid deposition brown right of image . Movat s stain . DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D005355 Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This is as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue. Scar ring is confluent fibrosis that obliterates the architecture of the underlying organ or tissue. The term is also sometimes used to describe a normal healing process, ref http dermnetnz.org pathology pathology glossary.html Glossary of dermatopathological terms. DermNet NZ Bot generated title ref but this usage is less common. Examples of fibrosis Image Cirrhosis high mag.jpg right thumb Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue Pulmonary fibrosis lungs Idiopathic pulmonary fibrosis where the cause is unknown Cystic fibrosis Cirrhosis liver Endomyocardial fibrosis heart Mediastinal fibrosis soft tissue of the mediastinum Myelofibrosis bone marrow Retroperitoneal fibrosis soft tissue of the retroperitoneum Progressive massive fibrosis lungs a complication of coal workers pneumoconiosis Nephrogenic systemic fibrosis skin Crohn s Disease intestine Keloid skin Old myocardial infarction heart Scleroderma systemic sclerosis skin, lungs Arthrofibrosis knee, shoulder, other joints .... ref References reflist External links DorlandsDict three 000040106 Fibrosis http web.me.com nmsprs ... Diseases and disorders disease stub ... bg ca Fibrosi de Fibrose es Fibrosis fr Fibrose id Fibrosis it Fibrosi pt Fibrose ru sv Fibros ta uk zh ...   more details



  1. Channel-conductance-controlling ATPase

    enzyme Name channel conductance controlling ATPase EC number 3.6.3.49 CAS number IUBMB EC number 3 6 3 49 GO code 0005260 image width caption In enzymology , a channel conductance controlling ATPase EC number 3.6.3.49 is an enzyme that catalysis catalyzes the chemical reaction ATP H sub 2 sub O math rightleftharpoons math ADP phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and water H sub 2 sub O , whereas its two product chemistry products are adenosine diphosphate ADP and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase channel conductance controlling . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1XMI and PDB link 1XMJ . References reflist 1 cite journal author Chen M, Zhang JT year 1996 title Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator CFTR in microsomal membranes journal Mol. Membr. Biol. volume 13 pages 33&ndash 40 pmid 9147660 doi 10.3109 09687689609160572 issue 1 cite journal author Tusnady GE, Bakos E, Varadi A, Sarkadi B year 1997 title Membrane topology distinguishes a subfamily of the ATP binding cassette ABC transporters journal FEBS. Lett. volume 402 pages 1&ndash 3 pmid 9013845 doi 10.1016 S0014 5793 96 01478 0 issue 1 cite journal author Sheppard DN, Welsh MJ year 1999 title Structure and function of the CFTR chloride channel journal Physiol. Rev. volume 79 pages S23&ndash 45 pmid 9922375 issue 1 Suppl Category EC 3.6.3 Category Enzymes of known structure hydrolase stub ...   more details



  1. Regulator

    Wiktionary Regulator may refer to Regulator automatic control , a device that maintains a designated characteristic, as in Battery regulator Pressure regulator Diving regulator Voltage regulator Regulator economics , an agency established by central government for the control of or intervention in the operation of markets Regulator gene , a gene involved in controlling the expression of one or more other genes Regulatory agency or Regulator, an agency responsible for exercising autonomous authority over some area of human activity A precision pendulum clock , originally used as a time standard for adjusting or regulating other clocks and watches An auxiliary physics concept used in regularization physics regularization Regulator mathematics , a positive real number used in Dirichlet s unit theorem A British term for a steam engine s throttle A component of Uilleann pipes , a form of bagpipes A flood control structure designed to manage the return of flood water from flood plains and diversion areas to the main channel Music and literature The Regulators , a novel by Stephen King writing as Richard Bachman The Regulator , a song by Clutch from Blast Tyrant Regulator , a song by Devin Townsend from Ocean Machine Biomech Groups of people A member of the Royal Navy Police A faction in the War of the Regulation 1760&ndash 1771 A member of the Shaysites, followers of Daniel Shays during Shays Rebellion 1786 A faction in the Regulator Moderator War 1839&ndash 1844 A vigilante organized in response to the Banditti of the Prairie 1835&ndash 1848 The Lincoln County Regulators , a deputized posse during the Lincoln County War 1878 See also lookfrom regulator intitle regulator Regulate disambiguation Regulation disambiguation Disambig cs Regul tor de Regulator fa fr R gulateur nl Regulator pt Regulador sv Regulator ...   more details



  1. Transmembrane channels

    caused by ion channel malfunctions include cystic fibrosis where the channel for the chloride ...Orphan date April 2012 Transmembrane channels , also called membrane channels , are pores within the lipid bilayer of the cell membrane . The channels are formed by large protein complexes that run across the membrane connecting the cytosol, or cytoplasm , to the extracellular matrix. ref Roux, B., and Schulten, K. 2004 . Computationals Studies of Membrane Channels. Structure 12, 1343 1351. ref Transmembrane channels are also found in the membranes of organelles including the nucleus , mitochondria and lysosome . ref Alberts, B., Bray, D., Hopkin, K., and Johnson, A. 2010 Essential Cell Biology, 3rd ed. New York Garland Science pp.  387 420. ref Transmembrane channels differ from transporters and pumps in several ways channels are not as selective as transporters and pumps, differentiating solutes primarily by size and ionic charge. Channels perform passive transport of materials also known as facilitated diffusion . Transporters can carry out either passive or active transfer of materials while pumps require energy to act. ref Lodish, H., Berk, A., Kaiser, C., Krieger, M., Scott, M., Bretscher, A., Ploegh, H., and Matsudaira, P. 2008 Molecular Cell Biology, 6th ed. New York W. H. Freeman pp.  437 474. ref There are several modes by which membrane channels operate. The most common is the gated channel which requires a trigger, such as a change in membrane potential in voltage gated channels, to unlock or lock the pore opening. Voltage gated channels are critical to the production of an action potential in neurons resulting in a nerve impulse. A ligand gated channel requires a chemical, such as a neurotransmitter , to activate the channel. Stress gated channels require a mechanical force applied to the channel for opening. Aquaporins are dedicated channels for the movement ... at a Glance. Journal of Cell Science 24, 2107 2112. ref Ion channels are a type of transmembrane ...   more details



  1. Transmembrane domain of ABC transporters

    ABCC6 ABCC8 ABCC9 Cystic fibrosis transmembrane conductance regulator CFTR TAP1 TAP2 TAPL References ...Pfam box Symbol ABC membrane Name ABC transporter transmembrane region image width caption Pfam PF00664 InterPro IPR001140 SMART PROSITE PDOC00364 SCOP 1pf4 TCDB 3.A.1 OPM family 1.1.10.03. Lipid drug exporters OPM protein 2hyd PDB PDB3 2hyd PDB3 3b60 ABC transporter transmembrane domain is main transmembrane Protein domains structural unit of ATP binding cassette transporter which consist of six transmembrane domain es. Many members of the ABC transporter family Pfam PF00005 have two such regions. ref name PUB00017897 cite journal author Kerr ID title Structure and association of ATP binding cassette transporter nucleotide binding domains journal Biochim. Biophys. Acta volume 1561 issue 1 pages 47 64 year 2002 pmid 11988180 ref . ref name PUB00017898 cite journal author Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K title Crystal structures of the MJ1267 ATP binding cassette reveal an induced fit effect at the ATPase active site of an ABC transporter journal Structure volume 9 issue 7 pages 571 86 year 2001 pmid 11470432 doi 10.1016 S0969 2126 01 00617 7 ref ref name PUB00017899 cite journal author Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ title The crystal structure of the MJ0796ATP binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter journal J. Biol. Chem. volume 276 issue 34 pages 32313 21 year 2001 pmid 11402022 doi 10.1074 jbc.M100758200 ref ref name PUB00004290 cite journal author Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF title Crystal structure of the ATP binding subunit of an ABC transporter journal Nature volume 396 issue 6712 pages 703 707 year 1998 pmid 9872322 doi 10.1038 25393 ref ref name PUB00025109 cite journal author ... families Category Transmembrane proteins membrane protein stub ...   more details



  1. Transmembrane protein

    A transmembrane protein TP is a protein that goes from one side of a membrane through to the other side ... membrane. A transmembrane protein is a polytopic protein that spans an entire biological membrane . Transmembrane proteins aggregate and precipitate in water. They require detergent s or nonpolar solvents .... Image Polytopic membrane protein.png thumb right 400px Schematic representation of transmembrane proteins 1. a single transmembrane helix bitopic membrane protein 2. a polytopic transmembrane helical protein 3. a polytopic transmembrane sheet protein br The membrane is represented in light brown. All transmembrane proteins are integral membrane protein s, but not all IMPs are transmembrane ... Academic Press isbn 978 0 12 370458 0 pages 37 ref Types There are two basic types of transmembrane ... category of transmembrane proteins. In humans, 27 of all proteins have been estimated to be alpha ... and chloroplasts . All beta barrel transmembrane proteins have simplest up and down topology ... molecules, while type IV are multiple pass molecules. Type I transmembrane proteins are anchored to the lipid ... of helical transmembrane proteins Transmembrane helix Transmembrane helical proteins are unusually ... dodecyl sulfate SDS micelles has four transmembrane helices folded, while the rest of the protein ... of water soluble proteins 10 kcal mol . Folding of helical transmembrane proteins Refolding of helical transmembrane proteins in vitro is technically difficult. There are relatively few ... are normally folded co translationally within the large transmembrane translocon .The translocon ... polar amphiphilic helix can adopt a transmembrane orientation in the translocon although it would ... helices into structures of transmembrane proteins. The amphiphilic helices remain attached to the translocon .... Stability and folding of barrel transmembrane proteins Stability of barrel transmembrane proteins ... Transmembrane cytochrome b like proteins http opm.phar.umich.edu families.php?superfamily 3 coenzyme ...   more details



  1. Transmembrane domain

    are commonly applied with a limited success. Online transmembrane prediction algorithm servers are listed ... differ and should be used with caution. Category Transmembrane proteins Category Protein structural ...   more details



  1. Thermal conductance

    For Thermal conductance see Thermal contact conductance Thermal conduction Thermal conductivity List of thermal conductivities disambig ...   more details



  1. Conductance (graph)

    Other uses Conductance disambiguation Conductance In graph theory the conductance of a Graph mathematics graph G V , E measures how well knit the graph is it controls how fast a random walk on G converges to a Uniform distribution discrete uniform distribution . The conductance of a graph is often called the Cheeger constant graph theory Cheeger constant of a graph as the analog of its Cheeger constant counterpart in spectral geometry . fact date May 2010 Since electrical networks are intimately related to random walk s with a long history in the usage of the term conductance , this alternative name helps avoid possible confusion. The conductance of a Cut graph theory cut math S, bar S math in a graph ... in V a ij math is the total number or weight of the edges incident with S . The conductance of the whole graph is the minimum conductance over all the possible cuts math phi G min S subseteq V varphi S . , math Equivalently, conductance of a graph is defined as follows math phi G min S subseteq V 0 leq a S leq a V 2 frac sum i in S, j in bar S a ij a S . , math For a d regular graph, the conductance ... applications, one often considers the conductance only over a cut. A common generalization of conductance ... is in the form of a resistance, then the reciprocal weights are added. The notion of conductance ... of petroleum through porous rock can be modeled in terms of the conductance of a graph, with weights ... Graph data structure graph G , the conductance is a way to measure how hard it is to leave a small set of nodes. Formally, the conductance of a graph is defined as the minimum over all sets math S math ... Sinclair showed that conductance is closely tied to mixing time in ergodic reversible Markov chains. We can also view conductance in a more probabilistic way, as the minimal probability of leaving ... probability of leaving a set of nodes S given that we were in that set to begin with, the conductance ... of at most 1 2. Conductance is related to Markov chain mixing time in the reversible setting ...   more details



  1. Sodium-hydrogen antiporter 3 regulator 1

    the cystic fibrosis transmembrane conductance regulator to the cytoskeleton journal J. Biol. Chem .... title An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton ... 2000 month September title The PDZ interacting domain of cystic fibrosis transmembrane conductance ... fibrosis transmembrane conductance regulator journal J. Biol. Chem. volume 276 issue 23 pages ... Young, Lee Min Goo, Muallem Shmuel, Kurtz Ira year 2002 month Dec. title The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3 salvage transporter ... A C terminal motif found in the 2 adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na H exchanger regulatory factor family of PDZ ... accessdate laysummary laysource laydate quote doi 10.1083 jcb.147.4.879 pmc 2156157 ref Cystic fibrosis transmembrane conductance regulator , ref name pmid12403779 ref name pmid9671706 ref name pmid12615054 ... Peptide binding consensus of the NHE RF PDZ1 domain matches the C terminal sequence of cystic fibrosis transmembrane conductance regulator CFTR journal FEBS Lett. volume 427 issue 1 pages 103 8 publisher ... binding chloride channel ClC 3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator interacting PDZ proteins journal J. Biol. Chem. volume 278 issue 8 pages ... jcb.139.1.169 pmc 2139813 ref and PDGFRA . ref name pmid11046132 See also Cystic fibrosis transmembrane conductance regulator Ezrin Moesin Neutron spin echo Radixin Solute carrier family References Reflist ... of the NHE RF PDZ1 domain matches the C terminal sequence of cystic fibrosis transmembrane conductance regulator CFTR journal FEBS Lett. volume 427 issue 1 pages 103 8 year 1998 pmid 9613608 ... A C terminal motif found in the 2 adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane ... Moyer BD, Duhaime M, Shaw C, et al. title The PDZ interacting domain of cystic fibrosis transmembrane ...   more details



  1. Conductance quantum

    The conductance quantum G sub 0 sub is the quantized unit of electrical conductance . It is defined as G sub 0 sub 2 elementary charge e sup 2 sup Planck constant h val 7.7480917346 25 e 5 u Ohm &Omega sup 1 sup Frac 1 12906.4037217   sup 1 sup . ref cite web author Barry N. Taylor, Peter J. Mohr url http physics.nist.gov cgi bin cuu Value?conqu2e2sh title CODATA Value Conductance Quantum year 2010 work http physics.nist.gov cuu index.html The NIST Reference on Constants, Units, and Uncertainty publisher National Institute of Standards and Technology accessdate 2011 06 23 ref It appears when measuring the conductance of a quantum point contact , and, more generally, is a key component of Landauer formula which relates the electrical conductance of a quantum conductor to its quantum properties. Note that the conductance quantum does not mean that the conductance of any system must be an integer multiple of G sub 0 sub . Instead, it describes the conductance of one quantum channel if the probability for transmitting an electron that enters the channel is unity, i.e. if transport through the channel is ballistic transport ballistic . If the transmission probability is less than unity, then the conductance of the channel is less than G sub 0 sub . The total conductance of a system is equal to the sum of the conductances of all the parallel quantum channels that make up the system. ref S. Datta, Electronic Transport in Mesoscopic Systems , Cambridge University Press, 1995, ISBN 0521599431 ref An intuitive motivation from the uncertainty principle A simple, intuitive motivation of the conductance quantum can made using the Heisenberg uncertainty principle , which states that the minimum energy time uncertainty is E t h , where h is the Planck constant . The current I in a quantum ... conductance G I V , this becomes G e sup 2 sup h . References reflist See also Quantum point contact Quantum wire Mesoscopic physics DEFAULTSORT Conductance Quantum Category Quantum electronics ...   more details



  1. Skin conductance

    Image gsr.svg thumb A sample GSR signal of 60 seconds. 400px right Skin conductance , also known as galvanic skin response GSR , electrodermal response EDR , psychogalvanic reflex PGR , skin conductance response SCR or skin conductance level SCL , is a method of measuring the electrical conductance of the human skin skin , which varies with its moisture level. This is of interest because the sweat glands are controlled by the sympathetic nervous system , ref Cite book last1 Martini first1 Frederic last2 Bartholomew first2 Edwin title Essentials of Anatomy & Physiology publisher Benjamin Cummings location San Francisco year 2003 page 267 isbn 0 13 061567 6 ref so skin conductance is used as an indication of psychological or physiological arousal . There has been a long history of electrodermal activity research, most of it dealing with spontaneous fluctuations or reactions to stimuli. Description The device measures the electrical conductance between 2 points, and is essentially a type of ohmmeter ... and muscle tissue to external and internal Stimulus physiology stimuli , the conductance can vary ... the reactions which may produce similar skin conductance responses. These reactions are utilized as part of the polygraph or lie detector . Skin conductance response in regular subjects differs when ... in skin conductance between fair and unfair offers. ref Oshumi, T., Ohira, H. The positive side ... it in many areas of psychological research. As of 2010, skin conductance monitoring equipment is still in use because it is inexpensive e.g. a galvanometer . Uses Skin conductance measurement is one ... . Many biofeedback therapy devices utilize skin conductance to measure and present an individual ... conductance measurement device. ref cite book title Mind Performance Projects for the Evil ... McGraw Hill Professional year 2009 isbn 9780071623926 page 31 ref Skin conductance measurement is also ... gsrtemp2x.htm GSR2 first portable unit, from 1976 Integumentary physiology DEFAULTSORT Skin Conductance ...   more details



  1. Stomatal conductance

    By definition, stomatal conductance , measured in mmol m s , is the measure of the rate of passage of carbon dioxide CO sub 2 sub entering, or water vapor exiting through the stoma ta of a leaf. Stomata are small pores on the top and bottom of a leaf that are responsible for taking in and expelling CO sub 2 sub and moisture from and to the outside air. The rate of stomatal conductance, or its inverse, stomatal resistance, is directly related to the boundary layer resistance of the leaf and the absolute concentration gradient of water vapor from the leaf to the atmosphere. It is under direct biological control of the leaf through the use of guard cells, which surround the stomatal pore ref cite book last Taiz Zeiger title Plant Physiology year 1991 publisher The Benjamin Cummings Publishing Company, Inc. location Redwood City, CA isbn 0 8053 0245 X pages 92 95 ref Taiz Zeiger 1991 . Stomatal conductance is integral to leaf level calculations of transpiration E . Methods for Measuring Stomatal conductance can be measured in several ways Steady state porometers A steady state porometer , such as the http www.decagon.com products environmental instruments stomatal conductance porometry instruments 2 sc 1 porometer for stomatal conductance measurements SC 1 Leaf Porometer from Decagon Devices, Inc., measures stomatal conductance using a sensor head with a fixed diffusion path to the leaf. It measures the vapor concentration at two different locations in the diffusion path. It computes vapor flux from the vapor concentration measurements and the known conductance of the diffusion path using the following equation ref cite web title First Look at Decagon s New Porometer url http ... are the resistances at the two sensors. If the temperatures of the two sensors are the same, conductance ... conductance is the reciprocal of resistance, therefore math g vs frac 1 R vs math . A dynamic porometer ... values found by these equations are typically converted to conductance values. References references ...   more details



  1. Fluid conductance

    Unreferenced date December 2009 Orphan date December 2009 Fluid conductance is related to the rate at which a unit of material can transmit fluids, and is used mainly in hydrology in relation to river and lake bottoms. It is an application of Permeability fluid intrinsic permeability to a unit of material with a defined area and thickness. In hydrology, the magnitude of conductance affects the rate of groundwater recharge or interaction with groundwater . This parameter is often used in such computer modelling codes as MODFLOW . Example For example, the conductance of water through a stream bed is math C b K frac A b math where math C b math is the conductance of the stream bed L sup 2 sup T sup 1 sup m sup 2 sup s sup 1 sup or ft sup 2 sup day sup 1 sup math K math is the hydraulic conductivity of the stream bed materials LT sup 1 sup m s sup 1 sup or ft day sup 1 sup math A math is the area of the stream bed L sup 2 sup m sup 2 sup or ft sup 2 sup math b math is the thickness of the stream bed sediments L m or ft The volumetric Discharge hydrology discharge through the stream bed can be calculated if the difference in hydraulic head is known math Q b C b h b h , math where math Q b math is the volumetric discharge through the stream bed L sup 3 sup T sup 1 sup m sup 3 sup s sup 1 sup or ft sup 3 sup day sup 1 sup math h b math is the hydraulic head of the river elevation stage math h math is the hydraulic head of the aquifer below the stream bed L m or ft See also Vascular resistance DEFAULTSORT Fluid Conductance Category Hydrology ...   more details



  1. Molecular conductance

    Molecular Conductance math G I V math , or the Electrical conductance conductance of a single molecule , is a physical quantity in molecular electronics . Molecular conductance is dependent on the surrounding conditions e.g. pH , temperature, pressure , as well as the properties of measuring device. Many experimental techniques have been developed in an attempt to measure this quantity directly, but theorists and experimentalists still face many challenges. ref Chen F, Hihath J, Huang Z, Li X, Tao NJ. 2007. Measurement of single molecule conductance. Annu. Rev. Phys. Chem. 58 535 64 ref br Recently, a great deal of progress has been made in the development of reliable conductance measuring techniques. These techniques can be divided into two categories molecular film experiments, which measure groups of tens of molecules, and single molecule measuring experiments. Molecular film experiments Molecular film experiments generally consist of the sandwiching of a thin layer of molecules between two electrodes which are used to measure the conductance through the layer. Two of the most successful implementations of this concept have been the bulk electrode approach and in the use of nanoelectrodes. In the bulk electrode approach, a molecular film is typically immobilized onto one electrode and an upper electrode is brought into contact with it allowing for a measure of current flow as a function of applied bias voltage . The nanoelectrode class of experiments, in creatively utilizing equipment such as atomic force microscope tips and small radius wires, are able to perform the same sorts of current versus applied bias measurements but on a much smaller number of molecules as compared to bulk electrode. For instance, the tip of an atomic force microscope can be used as a top electrode ... experimenters a better look at molecular conductance. These fall under the categories ... contact has an effect on the conductance and can change from one run of the experiment to the next ...   more details




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