intracytoplasmic cytoskeleton of epithelial tissue . The term cytokeratin began to be used in the late ... literature that used the term cytokeratin . Types Image Intermediate trophoblast lmwk high mag.jpg thumb right Micrograph showing low molecular weight cytokeratin LMWCK staining of intermediate trophoblast ... type I cytokeratin s and the basic chemistry basic or neutral type II cytokeratin s. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin . Basic or neutral ... cytokeratin fingerprint allows the classification of all epithelia upon their cytokeratin expression profile. Furthermore this applies also to the malignant counterparts of the epithelia carcinoma s , as the cytokeratin .... The main clinical implication is that the study of the cytokeratin profile by immunohistochemistry ... 19346656 doi 10.4103 0019 509X.49160 ref class wikitable Cytokeratin Sites Cytokeratin 4 Non keratinized ... October 2010 ref Cytokeratin 7 A subgroup of glandular epithelia and their tumors ref name mubio Transitional epithelium and transitional carcinoma ref name mubio Cytokeratin 8 Glandular epithelia ... cells Adenocarcinomas originating from those above ref name mubio Cytokeratin 10 Cytokeratin ... Differentiated areas of highly differentiated squamous cell carcinoma s ref name mubio Cytokeratin 13 Non keratinized squamous epithelia, except cornea ref name mubio Cytokeratin 14 Basal layer of stratified and combined epithelia ref name mubio Cytokeratin 18 Glandular epithelia of the digestive ... Adenocarcinomas originating from those above ref name mubio Cytokeratin 19 Glandular type epithelia ... ref name mubio Keratin 20 Cytokeratin 20 Glandular type epithelia. Signet ring round clear cells ... for trichocytes. All cytokeratin chains are composed of a central helix rich domain with a 50 ... form coiled dimers in solution. The end domain sequences of type I and II cytokeratin chains ... providing the cytokeratin chain a strong insoluble character and facilitating the interaction with other ... more details
Unreferenced stub auto yes date December 2009 Keratin 21 is a type I cytokeratin which expresses immunologically specific fusion protein. It is not found in humans, but only in Rattus norvegicus . Cytoskeletal proteins Category Keratins Protein stub ... more details
PBB geneid 3850 Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene . ref name pmid7510223 cite journal author Raimondi E, Moralli D, De Carli L, Ceratto N, Balzaretti M, Leube R, Collin C, Romano V title Assignment of the human cytokeratin 3 gene KRT3 to 12q12 q13 by FISH journal Cytogenet. Cell Genet. volume 66 issue 3 pages 162 3 year 1994 pmid 7510223 doi 10.1159 000133690 url issn ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J. Cell Biol. volume 174 issue 2 pages 169 74 year 2006 month July pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 url issn ref Keratin 3 is a type II cytokeratin . It is specifically found in the corneal epithelium together with keratin 12 . Mutations in the KRT3 encoding this protein have been associated with Meesmanns Corneal Dystrophy . ref name pmid9171831 cite journal author Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH title Mutations in cornea specific keratin K3 or K12 genes cause Meesmann s corneal dystrophy journal Nat. Genet. volume 16 issue 2 pages 184 7 year 1997 month June pmid 9171831 doi 10.1038 ng0697 184 url issn ref References Reflist Cytoskeletal proteins Gene 12 stub Category Keratins ru 3 ... more details
Ck1 may refer to Transportation AIDC F CK 1 Ching kuo , the Taiwainese fighter jet the F 16 variant, see F 16 Fighting Falcon variants Chang Kong CK 1 , the radio controlled target drone Cicar CK.1 , the Argentine helicopter the locomotive, see CK class Biochemistry the cytokeratin, see Type II keratin Casein kinase 1 , a family of protein kinases Asteroids 1994 CK1, see 10146 Mukaitadashi 1993 CK1, see 20043 Ellenmacarthur 1989 CK1, see 4836 Medon 1986 CK1, see 3951 Zichichi 1983 CK1, see 4198 Panthera Other the illicit drug cocktail, see cocaine and ketamine the Calvin Klein product, see Calvin Klein Pentecost biogeographic region, see Interim Biogeographic Regionalisation for Australia Letter NumberCombDisambig ... more details
34 E12 , often written as 34betaE12 and also known as CK34 E12 and keratin 903 CK903 , is an antibody specific for high molecular weight cytokeratin s Keratin 1 1 , Keratin 5 5 , Keratin 10 10 and Keratin 14 14 . ref cite journal author Aishima S, Asayama Y, Taguchi K, et al. title The utility of keratin 903 as a new prognostic marker in mass forming type intrahepatic cholangiocarcinoma journal Mod. Pathol. volume 15 issue 11 pages 1181 90 year 2002 month November pmid 12429797 doi 10.1097 01.MP.0000032537.82380.69 url http www.nature.com modpathol journal v15 n11 full 3880675a.html ref ref name yeh cite journal author Yeh IT, Mies C title Application of immunohistochemistry to breast lesions journal Arch. Pathol. Lab. Med. volume 132 issue 3 pages 349 58 year 2008 month March pmid 18318578 doi url http journals.allenpress.com jrnlserv ?request get abstract&issn 0003 9985&volume 132&page 349 ref It is sometimes, less precisely, referred to as high molecular weight keratin HMWK and high molecular weight cytokeratin HMWCK . Utility It is used to stain basal cell biology cell s in prostate prostatic glands loss of basal cells is seen in prostate adenocarcinoma the most common form of prostate cancer . It can be used to differentiate in situ cancers of the breast lobular carcinoma in situ LCIS exhibits peri nucleus cell nuclear staining with 34 E12. Ductal carcinoma in situ DCIS does not stain for 34 E12. ref name yeh See also Immunohistochemistry References reflist DEFAULTSORT 34 beta E12 Category Pathology ... more details
6B or 6b or VI B may refer to Keratin 6B , a type II cytokeratin Oflag VI B , a World War II German POW camp for officers located convert 5 km mi abbr on SW of the small town D ssel REL 6B Radar , a ground air surveillance and guidance radar Rumpler 6B , a 1916 German single engine floatplane fighter Season 6B , a popular fan theory related to the long running British science fiction television series Doctor Who Stalag VI B , a Nazi World War II camp for prisoners of war TUIfly Nordic IATA airline designator British Rail Class 203 Diesel electric Multiple Units, which were classed as 6B 6 coaches, Buffet pre TOPS 6B Fringe 6B Fringe , an episode of the television series Fringe 6 bits, like in 6b 8b encoding See also B6 disambiguation Letter NumberCombDisambig de 6B it 6B ... more details
ref ref cite journal author Feldstein AE et al. title Cytokeratin 18 fragment levels as noninvasive ... author Luft T et al. title Serum cytokeratin 18 fragments as quantitative markers of epithelial apoptosis ... Leers M et al. title Immunocytochemical detection and mapping of a cytokeratin 18 neo epitope exposed ... between Cell Death Modes using Measurements of Different Soluble Forms of Extracellular Cytokeratin ... more details
Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual ... Nordg rd O, Oltedal S, K rner H, et al. title The potential of cytokeratin 20 and mucin 2 mRNA as metastasis ... duct type of the pancreas with respect to expression of CD10 and cytokeratin 20. journal Pancreas ... journal author Gonz lez JJ, Bernardo CG, Sanz L, et al. title Mismatch repair protein MSH2, cytokeratin 18 and cytokeratin 20 expression clinicopathological correlation and prognostic value in colorectal ... Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. journal ... author Eissa S, Zohny SF, Swellam M, et al. title Comparison of CD44 and cytokeratin 20 mRNA in voided ... growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative ... more details
PBB geneid 3860 Keratin 13 or cytokeratin 13 is a protein that in humans is encoded by the KRT13 gene . ref name pmid1385306 cite journal author Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N title Chromosomal mapping of human cytokeratin 13 gene KRT13 journal Genomics volume 14 issue 2 pages 495 7 year 1992 month October pmid 1385306 doi 10.1016 S0888 7543 05 80250 2 url ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J. Cell Biol. volume 174 issue 2 pages 169 74 year 2006 month July pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 url ref Keratin 13 is a type I cytokeratin , it is paired with keratin 4 and found in the suprabasal layers of non cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus . ref name pmid7493031 cite journal author Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG title Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus journal Nat. Genet. volume 11 issue 4 pages 453 5 year 1995 month December pmid 7493031 doi 10.1038 ng1295 453 url ref K13 is negative in buccal epithelium. Citation needed date February 2010 References reflist Further reading refbegin 2 cite journal author title journal volume issue pages year pmid doi cite journal author Jacques CM, Pereira AL, Maia ... pmid 16836912 doi cite journal author Ceratto N, Dobkin C, Carter M, et al. title Human type I cytokeratin ... al. title Stage specific expression of the intermediate filament protein cytokeratin 13 in luminal ... and immunohistochemical analysis with cytokeratin 13 journal Eur. J. Obstet. Gynecol. Reprod ... to Cytokeratin 13 of Epithelial Cells journal Infect. Immun. volume 68 issue 4 pages 1787 95 year 2000 ... more details
of the chromosomal locus containing the cytokeratin 19 gene journal Eur. J. Cell Biol ... YK, et al. title Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma ... Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes journal ... al. title Identification of a subset of breast carcinomas characterized by expression of cytokeratin ... more details
Image CutaneousMyxoma.jpg right thumbnail Cutaneous Myxoma A cutaneous myxoma , AKA superficial angiomyxoma , consists of a multilobulated myxoid mass containing stellate and or spindled fibroblasts with pools of mucin forming cleft like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate. Staining is positive for vimentin , negative for cytokeratin and desmin , and variable for CD34 , Factor VIIIa, SMA Disambiguation needed date June 2011 , MSA Disambiguation needed date June 2011 and S 100 protein S 100 . ref name Review cite journal author Satter EK title Solitary superficial angiomyxoma an infrequent but distinct soft tissue tumor journal J. Cutan. Pathol. volume 36 issue Suppl 1 pages 56 9 year 2009 month October pmid 19187115 doi 10.1111 j.1600 0560.2008.01216.x url http www3.interscience.wiley.com cgi bin fulltext 121664953 HTMLSTART ref Clinically, it may present as solitary or multiple flesh colored nodules on the face, trunk, or extremities. It may occur as part of the Carney complex , and is sometimes the first sign. Local recurrence is common. ref name Andrews cite book last1 James first1 William last2 Berger first2 Timothy last3 Elston first3 Dirk title Andrews Diseases of the Skin Clinical Dermatology publisher Saunders year 2005 isbn 0 7216 2921 0 page 614 edition 10th ref See also Skin lesion Myxoma References reflist Dermal growth stub Soft tissue tumors and sarcomas Category Dermal and subcutaneous growths ... more details
PBB geneid 3880 Keratin, type I cytoskeletal 19 also known as cytokeratin 19 CK 19 or keratin 19 K19 is a protein that in humans is encoded by the KRT19 gene . ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J Cell Biol volume 174 issue 2 pages 169 74 year 2006 month Jul pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 ref ref name entrez cite web title Entrez Gene KRT19 keratin 19 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3880 accessdate ref Keratin 19 is a type I keratin . Function Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 is a type I keratin . The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cell s. It is specifically found in the periderm fish periderm , the transiently superficial layer that envelops the developing epidermis skin epidermis . The type I cytokeratins are clustered in a region of chromosome 17q12 q21. ref name entrez Use as biomarker Due to its high sensitivity, KRT19 is the most ... title Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail less intermediate ... derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene ... Shezen E, Okon E, Ben Hur H, Abramsky O title Cytokeratin expression in human thymus immunohistochemical ... M, et al. title Human type I cytokeratin genes are a compact cluster journal Cytogenet. Cell Genet ... of human cytokeratin 19 gene in human cholangiocarcinoma cell line journal J. Hepatol. volume 35 ... more details
related kinase associates with and phosphorylates cytokeratin 8 and 18 journal J. Cell Biol. volume ..., Elvin P, Jenner D, et al. title Localisation of a cDNA clone for human cytokeratin 18 to chromosome ... author Romano V, Hatzfeld M, Magin TM, et al. title Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone journal Differentiation ... Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins ... 363314 cite journal author S mat A, Vasseur M, Maillet L, et al. title Sequence analysis of murine cytokeratin ... more details
wiktionary CK .ck CK , Ck , or ck may refer to Biochemistry Creatine kinase Cytokinin , a kind of plant hormone Cytokeratin People known by the initials CK Prahalad , a professor at the University of Michigan Ross School of Business Louis C.K. Chaka Khan , American singer and songwriter Carrie Kelley , the first published female Robin Other seealso C K theory Ck digraph .ck , the Internet country code top level domain for the Cook Islands CK album CK album , 1998 album by Chaka Khan Calvin Klein Candidate key Chaka Khan 1982 album Chaka Khan 1982 album , Chaka Khan s self titled album Chairman King or Circus King , bosses in Okage video games Certified Kinesiologist , Chevrolet C K , car companies Chevrolet and GMC s full size Pickup truck line from 1960 until 1998 China Cargo Airlines s IATA code Citizen Kane Civilinis kodeksas , Code of Lithuania Composite Corridor , a designation of British Rail carriage Con Kolivas , the Linux Kernel developer Conductive keratoplasty Core Knowledge , a textbook series Corner kick Corner Kick , a method of restarting play in a game of association football Cranbrook Kingswood , a Bloomfield Hills school Crusader Kings video game , a grand strategy game made by Paradox Interactive Crip Killer, a member of the Bloods street gang Cyanogen chloride disambiguation cs CK de CK eo Ck fa CK fr CK ko CK it CK sw CK lv CK lt CK reik m s nl Ck ja CK no CK pl CK ro CK sl CK fi Ck sv CK zh CK ... more details
File Epidermal layers.png thumb Histologic image showing a section of epidermis. Stratum spinosum labeled slightly below center. The stratum spinosum or spinous layer is a layer of the epidermis skin epidermis found between the stratum granulosum and Stratum germinativum stratum basale . ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 Andrews Diseases of the Skin Clinical Dermatology 10th ed. . Saunders. Page 2. ISBN 0721629210. ref This layer is also referred to as the spinous or prickle cell layer. ref name Rooks McGrath, J.A. Eady, R.A. Pope, F.M. 2004 . Rook s Textbook of Dermatology Seventh Edition . Blackwell Publishing. Pages 3.7 3.8. ISBN 9780632064298. ref This appearance is due to desmosome desmosomal connections of adjacent cells. Keratinization begins in the stratum spinosum. ref name Lookingbill Marks, James G Miller, Jeffery 2006 . Lookingbill and Marks Principles of Dermatology 4th ed. . Elsevier Inc. Page 6. ISBN 1 4160 3185 5. ref This layer is composed of polyhedral keratinocytes, they have large pale staining nuclei as they are active in synthesizing fibrilar proteins, known as cytokeratin, which build up within the cells aggregating together forming tonofibrils . The tonofibrils go on to form the desmosomes allowing strong connections to form between adjacent keratinocytes. Additional images gallery Image Normal Epidermis and Dermis with Intradermal Nevus 10x.JPG Epidermis and dermis of human skin Image Skinlayers.png Section of epidermis gallery References reflist integumentary system Category Skin anatomy fr Stratum spinosum it Strato spinoso lt Dygliuotasis sluoksnis pl Warstwa kolczysta nask rka ja ... more details
Type 2 or Type II may refer to Type II machine pistol Type II , a Japanese Sub machine Gun Type 2 20 mm AA Machine Cannon , a Japanese weapon Type 2 AT mine Type 2 cannon , a 30 mm Japanese weapon Type 2 encryption Type 2 Gumbel distribution Type 2 Ho I , a Japanese tank Type 2 Ka Mi , a Japanese tank Type II cytokeratin Type II error used in statistics for a false negative error Type II string theory Type II superconductor Type II supernova Activin type 2 receptors Diabetes mellitus type 2 Glutaric acidemia type 2 Hyper IgM Syndrome Type 2 JDBC type 2 driver Kawanishi H8K , Type 2 flying boat code named Emily Multiple endocrine neoplasia type 2 Real Personal Trooper Type 2 Volkswagen Type 2 T3 Volkswagen Type 2 Atelosteogenesis, type II German Type II submarine Glycogen storage disease type II Hyperfinite type II factor Motorola Type II Neurofibromatosis type II R Type II Type I and type II errors Type II civilization , an advanced civilization on the Kardashev scale . IEC 62196 Type 2 IEC 62196 Type 2 connector type alias Mennekes Type British Railways Type 2 Diesel locomotives Type 2 may also refer to Albinism Charcot Marie Tooth disease Chomsky hierarchy Compact Cassette Compact Font Format CompactFlash Cyclic permutation Dbx noise reduction Gaucher s disease Hypersensitivity PC card Second degree heart block Spinal muscular atrophy Topoisomerase Usher syndrome Von Willebrand disease disambig ru 2 ... more details
Infobox Anatomy Name PAGENAME Latin myoepitheliocytus GraySubject GrayPage Image Caption Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Code TerminologiaHistologica 2 00 02.0.03059 Myoepithelial cells sometimes referred to as Myoepithelium are Cell biology cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the lumen anatomy lumenal cells. These may be positive for ACTA2 alpha smooth muscle actin and can contract and expel the secretions of exocrine glands . They are found in the sweat gland , mammary gland , lacrimal gland , and salivary gland . Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial Progenitor cell progenitor stem cells . In the case of wound healing , myoepithelial cells reactively cell growth proliferate . Presence of myoepithelial cells in a hyperplasia hyperplastic tissue proves the benign ity of the gland and, when absent, indicates cancer . Only rare cancers like adenoid cystic carcinoma s contains myoepithelial cells as one of the malignant components. It can be found in endoderm or ectoderm . ref name Berman2009 cite book author Jules J. Berman title Neoplasms principles of development and diversity url http books.google.com books?id WWnJ1 IM1yUC&pg PA207 accessdate 16 April 2010 year 2009 publisher Jones & Bartlett Learning isbn 9780763755706 pages 207 ref Markers Myoepithelial cells are true epithelial cell s positive for keratin s, not to be confused with myofibroblasts which are true mesenchymal cell s positive for vimentin . These cells are generally positive for alpha smooth muscle actin SMA , cytokeratin 5 6 and other high molecular weight cytokeratins, TP73L p63 and caldesmon . References reflist External links eMedicineDictionary Myoepithelium AnatomyAtlasesMicroscopic 07 141 Axillary Sweat Gland Myoepithelium OklahomaHistology 43 13 thick skin KansasHistology glands glands09 Simple Tubul ... more details
DISPLAYTITLE Technetium sup 99m sup Tc votumumab Drugbox Verifiedfields changed verifiedrevid 470478400 image drug name Technetium sup 99m sup Tc votumumab Monoclonal antibody data type mab mab type mab source u target tumor antigen CTAA16.88 Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status not marketed routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite changed ?? CAS number 148189 70 2 ATC prefix V09 ATC suffix IA04 ATC supplemental PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data chemical formula molecular weight Technetium sup 99m sup Tc votumumab trade name HumaSPECT is a human monoclonal antibody labelled with the radionuclide technetium 99m . ref http whqlibdoc.who.int druginfo INN 1999 list41.pdf WHO Drug Information ref It was developed for the detection of colorectal tumor s, but has never been marketed. ref name EMEA http www.emea.europa.eu pdfs human press pus 388504en.pdf EMA Public Statement on HumaSPECT ref The target of votumumab is CTAA16.88, a complex of cytokeratin polypeptides in the molecular weight range of 35 to 43 kDa , which is expressed in colorectal tumors. ref http ec.europa.eu enterprise sectors pharmaceuticals documents community register 1998 199809253252 anx 3252 en.pdf EMA Summary of Product Characteristics for HumaSPECT ref References reflist Radiopharmaceuticals Monoclonals for tumors Category Radiopharmaceuticals monoclonal antibody stub antineoplastic drug stub ... more details
Image Intermediate trophoblast high mag.jpg thumb right Micrograph showing intermediate trophoblasts. H&E stain . Image Intermediate trophoblast lmwk high mag.jpg thumb right Implantation site intermediate trophoblast. Low molecular weight cytokeratin stain. Intermediate trophoblast is a distinct subtype of trophoblast ic tissue that arises from the cytotrophoblast . ref name pmid11192071 cite journal author Shih IM, Kurman RJ title The pathology of intermediate trophoblastic tumors and tumor like lesions journal Int. J. Gynecol. Pathol. volume 20 issue 1 pages 31 47 year 2001 month January pmid 11192071 doi url ref It is sub categorized by location ref name pmid11192071 Implantation site intermediate trophoblast Villous intermediate trophoblast Chorionic type intermediate trophoblast Function The function of the implantation site intermediate trophoblast is to anchor the placenta to the maternal tissue. Histomorphology Large cells Eosinophilic cytoplasm May be multi nucleated Pathology Intermediate trophoblasts are thought to be the cell of origin for ref name pmid11192071 cite journal author Shih IM, Kurman RJ title The pathology of intermediate trophoblastic tumors and tumor like lesions journal Int. J. Gynecol. Pathol. volume 20 issue 1 pages 31 47 year 2001 month January pmid 11192071 doi url ref Exaggerated placental site EPS Placental site nodule PSN Placental site trophoblastic tumour PSTT Epithelioid trophoblastic tumour ETT References reflist Extraembryonic and fetal membranes Category Embryology ... more details
PBB geneid 3851 Keratin, type I cytoskeletal 4 also known as cytokeratin 4 CK 4 or keratin 4 K4 is a protein that in humans is encoded by the KRT4 gene . ref name pmid1702379 cite journal author Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V title Subchromosomal localization of two human cytokeratin genes KRT4 and KRT15 by in situ hybridization journal Cytogenet. Cell Genet. volume 54 issue 3 4 pages 148 50 year 1990 pmid 1702379 doi 10.1159 000132979 url ref ref name pmid16831889 cite journal author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW title New consensus nomenclature for mammalian keratins journal J. Cell Biol. volume 174 issue 2 pages 169 74 year 2006 month July pmid 16831889 pmc 2064177 doi 10.1083 jcb.200603161 url ref Keratin 4 is a type II cytokeratin s. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13 . Mutations in the genes encoding this protein have been associated with White Sponge Nevus , characterized by Wiktionary oral oral , esophageal , and anus anal leukoplakia . ref name pmid12828738 cite journal author Chao SC, Tsai YM, Yang MH, Lee JY title A novel mutation in the keratin 4 gene causing white sponge naevus journal Br. J. Dermatol. volume 148 issue 6 pages 1125 8 year 2003 month June pmid 12828738 doi 10.1046 j.1365 2133.2003.05337.x url ref References reflist Further reading refbegin 2 cite journal author Leube RE, Bader BL, Bosch FX, et al. title Molecular characterization and expression of the stratification related cytokeratins 4 and 15 journal J. Cell Biol. volume 106 issue 4 pages 1249 61 year 1988 pmid 2452170 pmc 2114990 doi 10.1083 jcb.106.4.1249 cite journal author Samen U, Eikmanns BJ, Reinscheid DJ, Borges F title The Surface Protein Srr 1 of Streptococcus agalactiae Binds ... assignments of human type I and type II cytokeratin genes to different chromosomes journal ... more details
, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin mediated cell adhesion ... J, Sato T, et al. title A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin ... more details
specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1 journal Cell Res. volume 15 issue ... more details
carcinoma . ref name Raul There is normally cytoplasmic staining for a number of cytokeratin s and the immunohistochemical ... cytokeratin AE1 AE3 pan cytokeratin CK8 18 cytokeratin 8 18 EMA epithelial membrane antigen GFAP glial ... more details
Encyclopedia
top
