Image Jakstat pathway.svg thumb 400px Key steps of the JAK STAT pathway for type 1 and 2 cytokine receptors Image Signal transduction pathways.svg thumb 400px Signal transduction. Cytokinereceptor at center left. Cytokinereceptor s are Receptor biochemistry receptor s that bind cytokine s. ref name ... II cytokinereceptor s, whose members are receptors mainly for interferon s. Immunoglobulin superfamily ... beta receptors Comparison class wikitable Type Examples Structure Mechanism type I cytokinereceptor Type 1 interleukin receptors Erythropoietin receptor GM CSF receptor G CSF receptor growth hormone receptor prolactin receptor Oncostatin M receptor Leukemia inhibitory factor receptor rowspan 2 Certain ... transduction pathways type II cytokinereceptor Type II interleukin receptors interferon alpha ... coupled TGF beta receptors TGF beta receptor 1 TGF beta receptor 2 Solubility Cytokine receptors ... Cytokine receptors Category Cytokine receptors membrane protein stub receptor stub cs Cytokinov ... publisher Wiley Blackwell isbn 9780470081587 pages 174 ref In recent years, the cytokine receptors ... of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now ..., many authorities are now of the opinion that a classification of cytokine receptors would be more clinically and experimentally useful. Classification A classification of cytokine receptors based ..., provides several unique perspectives for attractive pharmacotherapeutic targets. Type I cytokinereceptor s, whose members have certain conserved motifs in their extracellular amino acid domain. The IL 2 receptor belongs to this chain, whose chain common to several other cytokines deficiency ... of the vertebrate body Tumor necrosis factor receptor family , whose members share a cysteine rich common extracellular binding domain, and includes several other non cytokine ligands like CD40 , CD27 and CD30 , besides the ligands on which the family is named TNF . Chemokine receptor s, two of which ... more details
portion adjacent to the cell membrane. Members of the type I cytokinereceptor family comprise different chains, some of which are involved in ligand cytokine interaction and others that are involved ...Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokine s with four alpha helix helical strands. These receptors are also known ... between different receptors within this receptor family. ref name isbn0 7216 0008 5 cite book author ... Philadelphia year 2003 edition 5th pages isbn 0 7216 0008 5 oclc doi ref The IL 2 receptor common gamma chain also known as CD132 is shared between IL 2 receptor IL 4 receptor IL 7 receptor IL 9 receptor IL 13 receptor IL 15 receptor ref name pmid7530740 cite journal author He YW, Adkins B, Furse .... Distinct interaction of gamma c in the IL 4 receptor journal J. Immunol. volume 154 issue 4 ... 1596 ref The common beta chain CD131 or CDw131 is shared between the following type I cytokine receptors GM CSF receptor IL 3 receptor IL 5 receptor . ref name pmid9422786 cite journal author Stomski ... 5 receptors essential for disulfide linked receptor heterodimerization and activation of all ... jbc.273.2.1192 ref The gp230 receptor common gamma chain also known as gp130, IL6ST, IL6 beta or CD130 is shared between IL 6 receptor IL 11 receptor Leukamia inhibitory factor receptor Oncostatin M receptor Examples Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors Interleukin receptors Type 1 interleukin receptors Colony stimulating factor receptors Erythropoietin receptor GM CSF receptor G CSF receptor Hormone receptor neuropeptide receptor growth hormone receptor prolactin receptor Other Oncostatin M receptor Leukemia inhibitory factor receptor References Reflist External links MeshName Cytokine Receptors Cytokine receptors JAK STAT signaling pathway Category Cytokine receptors 1 Category Type I cytokine receptors ... more details
ref name pmid11481447 cite journal author Xu W title A soluble class II cytokinereceptor, IL 22RA2 ...Type II cytokine receptors are transmembrane protein s that are expressed on the surface of certain cells, which bind and respond to a select group of cytokine s. These Receptor immunology receptor s are similar to type I cytokinereceptor s except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. Structure Typically type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. Currently no complete structure of the extracellular domains of a type II cytokinereceptor is available. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase JAK family. Types Type II cytokine receptors include those that bind type I and type II interferon s, and those that bind members of the interleukin 10 family interleukin 10, interleukin 20 and interleukin 22 . ref name pmid12521379 cite journal author Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC title Cloning of a new type II cytokinereceptor ... receptors The interferon receptor is a molecule displayed on the surface of cells which allows them to interact with the anti viral substance interferon. The receptor is genetically coded for by number of different genes, as there are a few distinct types of interferon. Interferon receptor deficiency ... W title Correction of complete interferon gamma receptor 1 deficiency by bone marrow transplantation ... ref interferon alpha beta receptor interferon gamma receptor Interleukin receptors Type II interleukin receptors To edit, search for Template Type II interleukin receptors References Reflist 2 Cytokine receptors JAK STAT signaling pathway Category Cytokine receptors 2 immunology stub ... more details
date October 2009 Each cytokine has a matching Receptor biochemistry cell surface receptor . Subsequent ... inflammation . Cytokine receptors Main Cytokinereceptor In recent years, the cytokine receptors have ... the term cytokine encompasses a large and diverse family of regulators produced throughout the body ... New York year 2001 isbn 0 07 135469 7 ref The term cytokine has been used to refer to the immunomodulator ... processes during embryogenesis ref cite journal title Cytokine cross talk between mother and the embryo ... receptor in preimplantation embryos journal Journal of Reproductive Biology date October 1999 first ... of a particular cytokine on a given cell depends on the cytokine, its extracellular abundance, the presence and abundance of the complementary receptor on the cell surface, and downstream signals activated by receptor binding these last two factors can vary by cell type. Cytokines are characterized ... to be a paradox that cytokines binding to antibody antibodies have a stronger immune effect than the cytokine ... White blood cell leukocytes . It is now used largely for designation of newer cytokine molecules ... Huang first3 H last4 Lavoie first4 JP last5 Laverty first5 S title Cytokine and chemokine gene expression ... characteristics, and partly because a deficiency of cytokine receptors has now been ..., many authorities think that a classification of cytokine receptors would be more clinically and experimentally useful. A classification of cytokine receptors based on their three dimensional structure ... , cell adhesion molecule s, and even some cytokines. Examples IL 1 receptor types. Haemopoietic ... amino acid domain. The IL 2 receptor belongs to this chain, whose chain common to several other cytokines ... several other non cytokine ligands like CD40 , CD27 and CD30 , besides the ligands on which the family is named TNF . 7TM Receptor Seven transmembrane helix family, the ubiquitous receptor type ... pmid11239407 cite journal author Locksley RM, Killeen N, Lenardo MJ title The TNF and TNF receptor ... more details
and Angiotensin receptor blockers have theoretical benefit in downregulation of the cytokine storm. ref ...Infobox disease Name Cytokine storm Image Caption DiseasesDB 34296 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID A cytokine storm , or hypercytokinemia is a potentially fatal immune reaction consisting of a positive feedback loop between cytokine s and immune cell s, with highly ... id pmid 15872196 ref Symptoms The primary symptoms of a cytokine storm are high fever , swelling .... Cytokine storms have potential to do significant damage to body tissues and organs. If a cytokine ... and eventually block off the airways, potentially resulting in death. The cytokine storm hypercytokinemia ... 1, and Interleukin 6 and anti inflammatory cytokines such as interleukin 10 and interleukin 1 receptor antagonist are elevated in the Serous fluid serum of patients experiencing a cytokine storm. ref ... about systemic inflammatory response ref Cytokine storms can occur in a number of infectious and non ... ref Cytokine storm may also be induced by certain medications. The experimental drug TGN1412 caused ... S1470 2045 07 70004 9 author Thelancetoncology, pages 85 ref likely due to a cytokine storm ref ... trial Phase I Phase I trial . The first reference to the term cytokine storm in the published medical ..., DG. Gilliland title Cytokine storm of graft versus host disease a critical effector role for interleukin ... that cytokine storms were responsible for many of the deaths during the Spanish flu 1918 influenza ..., Theron M, Wu YC, Lai SK, Liu CC, Lei HY title An interferon gamma related cytokine storm in SARS patients ... pmid 15602737 doi 10.1002 jmv.20255 url ref Human deaths from the bird flu H5N1 usually involve cytokine ... in the 2009 H1N1 flu outbreak 2009 swine flu outbreak has led to speculation that cytokine storms could ... 14568982 ref the possibility of preventing a cytokine storm by inhibiting or disabling T cell response ... and subsequently increasing cytokine production. A combined protein, OX40 immunoglobulin OX40 Ig ... more details
A proinflammatory cytokine is a cytokine which promotes systemic inflammation . Examples include IL 1 ref name pmid10936147 cite journal author Dinarello CA title Proinflammatory cytokines journal Chest volume 118 issue 2 pages 503 8 year 2000 month August pmid 10936147 doi 10.1378 chest.118.2.503 url http www.chestjournal.org cgi pmidlookup?view long&pmid 10936147 ref and TNF alpha . ref name pmid12480361 cite journal author Cheung CY, Poon LL, Lau AS, et al. title Induction of proinflammatory cytokines in human macrophages by influenza A H5N1 viruses a mechanism for the unusual severity of human disease? journal Lancet volume 360 issue 9348 pages 1831 7 year 2002 month December pmid 12480361 doi 10.1016 S0140 6736 02 11772 7 url http linkinghub.elsevier.com retrieve pii S0140673602117727 ref References Reflist Cytokines Category Cytokines sr Proinflamatorni citokin zh immunology stub ... more details
Unreferenced date December 2009 Infobox disease Name Cytokine release syndrome Image Caption DiseasesDB 34296 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Cytokine release syndrome is a common immediate complication occurring with the use of anti T cell antibody infusions such as Anti thymocyte globulin ATG , OKT3 and TGN1412 , but also with the CD 20 antibody rituximab . Severe cases are known as cytokine storm s. The pathogenesis is that the antibody antibodies bind to the T cell receptor, activating the T cells before they are destroyed. The cytokine s released by the activated T cells produce a type of systemic inflammatory response syndrome systemic inflammatory response similar to that found in severe infection characterised by hypotension , pyrexia and rigor medicine rigors . The patient feels very unwell, as if in a high fever &ndash indeed, the cytokine release syndrome is effectively a type of non infective fever. Deaths due to cytokine release syndrome with OKT3 muromonab CD3 have been reported, and it can cause life threatening pulmonary edema if the patient is fluid overloaded. However, if treated appropriately it is usually not dangerous, just extremely unpleasant for the patient. The effect is greatly reduced by using low dose OKT3 e.g. 2 mg instead of 5 mg, slow infusion instead of rapid injection, intravenous administration of an anti histamine such as chlorphenamine and a corticosteroid such as hydrocortisone prior to starting the ATG OKT3 infusion, with further doses of anti histamine and steroid given during the infusion if necessary, Acetaminophine 500 mg by mouth 1 hour before infusion to prevent fever. Moreover, it is recommended that any overhydration to be corrected before the administration the 1st dose either by dialysis or with intravenous furosemide, to prevent the possible development of pulmonary oedema. See also cytokine storm , life threatening massive release of cytokines DEFAULTSORT Cytokine Release ... more details
wiktionary Receptor may refer to Cellular Sensory receptor , in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse Molecular Receptor biochemistry , in biochemistry, a protein molecule that receives and responds to a neurotransmitter, or other substance Special cases of receptors in biochemistry Cell surface receptor , a receptor on the outer surface of a cell membrane, that takes part in communication between the cell and the outside world Nuclear receptor , a receptor found within cells that is responsible for sensing steroid and thyroid hormones and certain other molecules Immune receptor , a receptor that occurs on the surface of immunocytes and binds to antigens Telecommunication Receiver radio , a device for the reception of electromagnetic signals disambig ar ca Receptor fr R cepteur id Reseptor it Recettore lt Receptorius nl Receptor oc Receptor ro Receptor ru sl Receptor fi Reseptori zh ... more details
receptor. A potential mechanism for cytokine mediated insulin resistance journal J. Biol .... PBB geneid 8651 Suppressor of cytokine signaling 1 is a protein that in humans is encoded ... NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A title A novel cytokine inducible gene CIS encodes ... inhibitor SSI , also known as suppressor of cytokine signaling SOCS , family. SSI family members are cytokine inducible negative regulators of cytokine signaling. The expression of this gene can be induced ... IFN gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested ... and survival. ref name entrez cite web title Entrez Gene SOCS1 suppressor of cytokine signaling ... ref See also SOCS JAK STAT signaling pathway Interactions Suppressor of cytokine signaling 1 has been ... E, Demeneix B, Kelly P A, Edery M year 2001 month Dec. title Cytokine inducible SH2 containing protein suppresses PRL signaling by binding the PRL receptor journal Endocrinology journal Endocrinology ... August title Inhibition and restoration of prolactin signal transduction by suppressors of cytokine ... format accessdate laysummary laysource laydate quote ref Growth hormone receptor , ref name pmid10585430 ... laysource laydate quote ref Colony stimulating factor 1 receptor ref name pmid11297560 cite journal ..., Mouchiroud G year 2001 month June title Suppressor of cytokine signaling 1 interacts with the macrophage colony stimulating factor receptor and negatively regulates its proliferation signal journal ... of cytokine signaling journal Stem Cells volume 19 issue 5 pages 378 87 year 2001 pmid 11553846 doi 10.1634 stemcells.19 5 378 cite journal author Wang J, Campbell IL title Cytokine signaling in the brain ... TA, Viney EM, et al. title A family of cytokine inducible inhibitors of signalling journal Nature ... RW title Interaction of human suppressor of cytokine signaling SOCS 2 with the insulin like growth ... more details
SOCS suppressor of cytokine signaling proteins refers to a family of genes involved in inhibiting the JAK STAT signaling pathway . Genes SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 External links MeshName Suppressor of Cytokine Signaling Proteins JAK STAT signaling pathway Category Cell signaling biochemistry stub The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling SOCS , also known as STAT induced STAT inhibitor SSI , protein family. SOCS family members are known to be cytokine inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jul 2008 ... more details
protein Name interleukin 11 receptor alpha subunit interleukin 11 receptor, alpha caption image width HGNCid 5967 Symbol interleukin 11 receptor alpha subunit IL11RA AltSymbols EntrezGene 3590 OMIM 600939 RefSeq NM 004512 UniProt Q14626 PDB ECnumber Chromosome 9 Arm p Band 13 LocusSupplementaryData protein Name interleukin 11 receptor, beta caption image width HGNCid 5968 Symbol IL11RB AltSymbols EntrezGene OMIM RefSeq UniProt PDB ECnumber Chromosome Arm Band LocusSupplementaryData The interleukin 11 receptor is a type I cytokinereceptor , binding interleukin 11 . It is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. ref name pmid7670098 cite journal author Ch rel M, Sorel M, Lebeau B, Dubois S, Moreau JF, Bataille R, Minvielle S, Jacques Y title Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin 11 journal Blood volume 86 issue 7 pages 2534 40 year 1995 pmid 7670098 doi issn url http bloodjournal.hematologylibrary.org cgi content abstract bloodjournal 86 7 2534 ref References Reflist External links MeshName Receptors, Interleukin 11 Cytokine receptors Category Cytokine receptors 1 Category Type I cytokine receptors membrane protein stub ... more details
An immune receptor or immunologic receptor is a Receptor biochemistry receptor , usually on a cell membrane , which binds to a substance for example, a cytokine and causes a response in the immune system . Types The main receptors in the immune system are pattern recognition receptors PRRs , Toll like receptor s TLRs , killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs , complement receptor s, Fc receptors , B cell receptor s and T cell receptor s. ref name Immunology20Unless Lippincott s Illustrated Reviews Immunology. Paperback 384 pages. Publisher Lippincott Williams & Wilkins July 1, 2007 . Language English. ISBN 0781795435. ISBN 978 0781795432. Page 20 ref class wikitable Comparison Receptor Bind to ref name Immunology20Unless Function ref name Immunology20Unless align left pattern recognition receptors PRRs br e.g. Toll like receptor TLRs , NOD like receptor NLRs pathogen associated molecular pattern s PAMP Mediate cytokine production inflammation destroying pathogen killer activated receptor killer activated and killer inhibitor receptor s KARs and KIRs Avails NK cells to identify abnormal host cells KAR or inhibit inappropriate host cell destruction KIR complement receptor s complement proteins on e.g. microbes Allow phagocytic and B cells to recognize microbes and immune complexes Fc receptors epitope antibody complexes Stimulate phagocytosis B cell receptor s epitope s B cell differentiation into plasma cells and proliferation T cell receptor s linear epitopes bound to major histocompatibility complex MHC Activate T cells Cytokinereceptor s cytokine s regulation and co ordination of immune responses See also antigen templates at bottom References references External links MeshName immunologic receptor Transmembrane receptors Immune receptors Category Immune system nl Immuunreceptor ar ... more details
protein Name IL3RA interleukin 3 receptor, alpha caption image width HGNCid 6012 Symbol IL3RA AltSymbols CD123 EntrezGene OMIM 308385 RefSeq UniProt PDB ECnumber Chromosome X Arm p Band 22.3 LocusSupplementaryData protein Name interleukin 3 receptor, Y Chromosomal caption image width HGNCid 6012 Symbol IL3RA AltSymbols IL3RY, IL3RAY EntrezGene 3563 OMIM 430000 RefSeq UniProt PDB ECnumber Chromosome Y Arm p Band 11.3 LocusSupplementaryData The interleukin 3 receptor also known as CD123 antigen is a molecule found on cells which helps transmit the signal of interleukin 3 , a soluble cytokine important in the immune system . The gene coding for the receptor is located in the pseudoautosomal region of the X chromosome X and Y chromosome s. The receptor belongs to the type I cytokinereceptor family and is a heterodimer with a unique alpha chain paired with the common beta beta c or CDw131 subunit. The gene for the alpha subunit is 40 kilobase s long and has 12 exon s. The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. External links MeshName Interleukin 3 ReceptorCytokine receptors Category Cytokine receptors immunology stub sr Interleukin 3 receptor ... more details
Refimprove date February 2008 An interleukin receptor is a cytokinereceptor for interleukin s. Types There are two main families of Interleukin receptors, type 1 cytokine receptors type 1 and type 2 cytokine receptors . Type 1 Type 1 interleukin receptors include ref name pmid15062641 cite journal author Subramaniam S, Stansberg C, Cunningham C title The interleukin 1 receptor family journal Dev. Comp. Immunol. volume 28 issue 5 pages 415 28 year 2004 month May pmid 15062641 doi 10.1016 j.dci.2003.09.016 url issn ref ref name pmid17027517 cite journal author Boraschi D, Tagliabue A title The interleukin 1 receptor family journal Vitam. Horm. volume 74 issue pages 229 54 year 2006 pmid 17027517 doi 10.1016 S0083 6729 06 74009 2 issn ref Type 1 interleukin receptors Type 2 Type 2 interleukin receptors include ref name pmid15123776 cite journal author Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H title The expanded family of class II cytokines that share the IL 10 receptor 2 IL 10R2 chain journal J. Leukoc. Biol. volume 76 issue 2 pages 314 21 year 2004 month August pmid 15123776 doi 10.1189 jlb.0204117 url issn ref Type 2 interleukin receptors Other Interleukin 1 receptor and interleukin 18 receptor belong to the immunoglobulin superfamily . Interleukin 8 receptor , RANTES receptors CCR1 , CCR3 , CCR5 , CCR1 MIP 1 receptor , CXCR4 PF4 receptor , Colony stimulating factor 1 receptor M CSF receptor and NAP 2 receptor belong to the chemokine receptor family. References Reflist External links MeshName Receptors, Interleukin Cytokine receptors Category Immunology membrane protein stub it Recettore delle interleuchine ... more details
Unreferenced stub auto yes date December 2009 Orphan date December 2009 The somatotropin receptor , or growth hormone receptor , is a member of the cytokinereceptor superfamily. One growth hormone molecule binds to one Receptor biochemistry receptor and then recruits a second receptor to form a protein dimer dimer through which Cell signaling signalling occurs. Growth hormone has a Gaussian function bell shaped dose response curve because high concentrations actually prevent dimerization of the receptors and prevent signalling. DEFAULTSORT Somatotropin Receptor Category Transmembrane receptors Biochemistry stub ... more details
protein Name interleukin 22 receptor, alpha 1 caption image width HGNCid 13700 Symbol IL22RA1 AltSymbols IL22R EntrezGene 58985 OMIM 605457 RefSeq NM 021258 UniProt A8K839 PDB ECnumber Chromosome 1 Arm p Band 36.11 LocusSupplementaryData protein Name IL22RA2 interleukin 22 receptor, alpha 2 caption image width HGNCid 14901 Symbol IL22RA2 AltSymbols EntrezGene 116379 OMIM 606648 RefSeq NM 181310 UniProt Q969J5 PDB ECnumber Chromosome 6 Arm q Band 24.1 LocusSupplementaryData 24.2 Interleukin 22 receptor is a type II cytokinereceptor . It binds to Interleukin 22 . It is a heterodimer of 1 ref name pmid10875937 cite journal author Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood WI, Goddard AD, Gurney AL title Interleukin IL 22, a novel human cytokine that signals through the interferon receptor related proteins CRF2 4 and IL 22R journal J. Biol. Chem. volume 275 issue 40 pages 31335 9 year 2000 pmid 10875937 doi 10.1074 jbc.M005304200 ref and IL22RA2 2 ref name pmid11481447 cite journal author Xu W, Presnell SR, Parrish Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, Schlutsmeyer S, Yao L, Whitmore TE, Chandrasekher Y, Grant FJ, Maurer M, Jelinek L, Storey H, Brender T, Hammond A, Topouzis S, Clegg CH, Foster DC title A soluble class II cytokinereceptor, IL 22RA2, is a naturally occurring IL 22 antagonist journal Proc. Natl. Acad. Sci. U.S.A. volume 98 issue 17 pages 9511 6 year 2001 pmid 11481447 doi 10.1073 pnas.171303198 pmc 55483 ref subunits. References Reflist External links MeshName Receptors, Interleukin 22 Cytokine receptors Category Cytokine receptors 1 Category Type II cytokine receptors membrane protein stub ... more details
protein Name interleukin 5 receptor alpha subunit interleukin 5 receptor, alpha caption image width HGNCid 6017 Symbol interleukin 5 receptor alpha subunit IL5RA AltSymbols IL5R EntrezGene 3568 OMIM 147851 RefSeq NM 175725 UniProt Q01344 PDB ECnumber Chromosome 3 Arm p Band 26 LocusSupplementaryData p24 protein Name CSF2RB colony stimulating factor 2 receptor, beta, low affinity granulocyte macrophage caption image width HGNCid 2436 Symbol CSF2RB AltSymbols IL3RB EntrezGene 1439 OMIM 138981 RefSeq NM 000395 UniProt P32927 PDB ECnumber Chromosome 22 Arm q Band 12.2 13.1 LocusSupplementaryData The interleukin 5 receptor is a type I cytokinereceptor . It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB . ref name pmid1773042 cite journal author Takatsu K, Tominaga A title Interleukin 5 and its receptor journal Prog. Growth Factor Res. volume 3 issue 2 pages 87 102 year 1991 pmid 1773042 doi 10.1016 S0955 2235 05 80001 8 ref ref name pmid1732409 cite journal author Murata Y, Takaki S, Migita M, Kikuchi Y, Tominaga A, Takatsu K title Molecular cloning and expression of the human interleukin 5 receptor journal J. Exp. Med. volume 175 issue 2 pages 341 51 year 1992 pmid 1732409 doi 10.1084 jem.175.2.341 pmc 2119102 ref References Reflist External links MeshName Receptors, Interleukin 5 Cytokine receptors Category Cytokine receptors 1 Category Type I cytokine receptors membrane protein stub ... more details
Interleukin 7 receptor IL7R also known as CD127 C luster of D ifferentiation 127 is a type I cytokinereceptor . Category Human proteins Category Type I cytokine receptors ... more details
protein Name interleukin 27 receptor, alpha subunit interleukin 27 receptor, alpha caption image width HGNCid 17290 Symbol interleukin 27 receptor, alpha subunit IL27RA AltSymbols WSX 1, TCCR, CRL1, WSX1, zcytor1, IL 27R EntrezGene 9466 OMIM 605350 RefSeq NM 004843 UniProt Q6UWB1 PDB ECnumber Chromosome 19 Arm p Band 13.11 LocusSupplementaryData protein Name glycoprotein 130 interleukin 6 signal transducer gp130, oncostatin M receptor caption image width HGNCid 6021 Symbol Glycoprotein 130 IL6ST AltSymbols GP130, CD130 EntrezGene 3572 OMIM 600694 RefSeq NM 002184 UniProt P40189 PDB ECnumber Chromosome 5 Arm q Band 11 LocusSupplementaryData The interleukin 27 receptor is a type I cytokinereceptor for interleukin 27 . It is a protein dimer heterodimer composed of the interleukin 27 receptor, alpha subunit ref name pmid9600072 cite journal author Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O Hara PJ, Foster DF title Cloning and characterization of a novel class I cytokinereceptor journal Biochem. Biophys. Res. Commun. volume 246 issue 1 pages 82 90 year 1998 pmid 9600072 doi 10.1006 bbrc.1998.8576 ref ref name pmid11057672 cite journal author Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ title Development of Th1 type immune responses requires the type I cytokinereceptor TCCR journal Nature volume 407 issue 6806 pages 916 20 year 2000 pmid 11057672 doi 10.1038 35038103 ref and glycoprotein 130 . ref name pmid14764690 cite journal author Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA title WSX 1 and glycoprotein 130 constitute a signal transducing receptor for IL 27 journal Journal of immunology Baltimore, Md. 1950 volume ... abstract 170 10 4886 ref References Reflist 2 External links MeshName Receptors, Interleukin 27 Cytokine receptors Category Cytokine receptors 1 Category Type I cytokine receptors membrane protein stub ... more details
protein Name interleukin 1 receptor, type I caption image width HGNCid 5993 Symbol Interleukin 1 receptor, type I IL1R1 AltSymbols IL1R, IL1RA EntrezGene 3554 OMIM 147810 RefSeq NM 000877 UniProt P14778 PDB ECnumber Chromosome 2 Arm q Band 12 LocusSupplementaryData protein Name interleukin 1 receptor, type II caption image width HGNCid 5994 Symbol interleukin 1 receptor, type II IL1R2 AltSymbols IL1RB EntrezGene 7850 OMIM 147811 RefSeq NM 173343 UniProt P27930 PDB ECnumber Chromosome 2 Arm q Band 12 LocusSupplementaryData protein Name IL1RAP interleukin 1 receptor accessory protein caption image width HGNCid 5995 Symbol IL1RAP AltSymbols IL 1RAcP, IL1R3, C3orf13 EntrezGene 3556 OMIM 602626 RefSeq NM 134470 UniProt Q9NPH3 PDB ECnumber Chromosome 3 Arm q Band 28 LocusSupplementaryData Interleukin 1 receptor IL 1R is a cytokinereceptor which binds interleukin 1 . ref name pmid7964161 cite journal author Kuno K, Matsushima K title The IL 1 receptor signaling pathway journal J. Leukoc. Biol. volume 56 issue 5 pages 542 7 year 1994 pmid 7964161 doi url http www.jleukbio.org cgi content abstract 56 5 542 format abstract page ref Two forms of the receptor exist. The interleukin 1 receptor, type I type I receptor is primarily responsible for transmitting the inflammation inflammatory effects of interleukin 1 IL 1 while interleukin 1 receptor, type II type II receptors may act as a suppressor ... of IL 1 is the interleukin 1 receptor antagonist IL 1 receptor antagonist IL 1RA . ref name pmid1834696 cite journal author Arend WP title Interleukin 1 receptor antagonist. A new member of the interleukin ... 10.1172 JCI115453 pmc 295645 ref The IL 1 receptor accessory protein IL1RAP is a transmembrane protein ... journal author Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU title The interleukin 1 receptor accessory protein IL 1RAcP is essential for IL 1 induced activation of interleukin 1 receptor ... References Reflist External links MeshName Receptors, Interleukin 1 Cytokine receptors Category Cytokine ... more details
Interleukin 15 receptor is a type I cytokinereceptor , binding interleukin 15 . It consists of an interleukin 15 receptor, alpha subunit and shares common IL2RB beta and IL2RG gamma subunits with the IL 2 receptor . ref name pmid8530383 cite journal author Anderson DM, Kumaki S, Ahdieh ...protein Name interleukin 15 receptor, alpha subunit interleukin 15 receptor, alpha caption image Protein IL15RA PDB 2ers.png image source Protein Data Bank PDB rendering based on 2ers. width HGNCid 5978 Symbol interleukin 15 receptor, alpha subunit IL15RA AltSymbols EntrezGene 3601 OMIM 601070 RefSeq NM 172200 UniProt Q13261 PDB ECnumber Chromosome 10 Arm p Band 15 LocusSupplementaryData 10p14 protein Name IL2RB interleukin 2 receptor, beta caption image Protein IL2RB PDB 2b5i.png image source Protein Data Bank PDB rendering based on 2b5i. width HGNCid 6009 Symbol IL2RB AltSymbols CD122 EntrezGene 3560 OMIM 146710 RefSeq NM 000878 UniProt P14784 PDB ECnumber Chromosome 22 Arm q Band 13 LocusSupplementaryData protein Name IL2RG interleukin 2 receptor, gamma severe combined immunodeficiency caption image Protein IL2RG PDB 2b5i.png image source Crystallographic structure of Interleukin 2 IL 2 center alpha helix alpha helices complexed with the common gamma chain IL2RG 10 O Clock to 1 O Clock , IL2RA 4 O Clock , and IL2RB 7 O Clock to 9 O Clock . Each protein is individually rainbow colored N terminus blue, C terminus red . ref name pmid16293754 PDB 2B5I cite journal author Wang X, Rickert M, Garcia KC title Structure of the quaternary complex of interleukin 2 with its alpha, beta, and gammac receptors journal Science volume 310 issue 5751 pages 1159 63 year 2005 month November pmid ... characterization of the human interleukin 15 receptor alpha chain and close linkage of IL15RA and IL2RA ... jbc.270.50.29862 ref References Reflist External links MeshName Receptors, Interleukin 15 Cytokine receptors Category Cytokine receptors 1 Category Type I cytokine receptors membrane protein stub ... more details
Encyclopedia
top
