Tissue typing is a procedure in which the tissues of a prospective donor and recipient are tested for compatibility prior to Organ transplant transplantation . An embryo can be tissue typed to ensure that the embryo implanted can be a cord blood stem cell donor for a sick sibling. ref Designing Donors . Shaun D. Pattinson, Faculty of Law and Sheffield Institute of Biotechnological Law and Ethics, University of Sheffield. http www.ccels.cf.ac.uk literature issue 2003 pattinson.pdf link ref One technique of tissue typing, mixed leukocyte reaction , is performed by culturing lymphocytes from the donor together with those from the recipient. ref http pathmicro.med.sc.edu ghaffar mhc2000.htm MHC Bot generated title ref Another technique, known as a micro cytotoxicity assay, utilizes serum with known anti HLA antibodies that recognize particular human leukocyte antigen HLA loci HLA A, HLA B, HLA C, HLA DP, HLA DQ, HLA DR in order to match genetically similar individuals in hopes of performing a tissue transplantation. In this technique a donor s blood cells are major histocompatibility complex MHC typed by mixing them with Blood serum serum containing the anti HLA antibodies . If the antibodies recognize their epitope on the MHC then classical complement pathway complement activation occurs and the cell will be osmotically lysis lysed . Lysis results in the cell taking up a dye trypan blue . This allows identification of cell s MHC indirectly based on the specificity of the known antibodies in the serum. See also Histocompatibility References references External links http www.hfea.gov.uk preimplantation tissue typing.html How Preimplantation tissue typing works, HFEA website MeshName Tissue typing http www.stanford.edu dept HPS transplant html tt 1.html http www.bchealthguide.org kbase topic medtest hw40261 descrip.htm Category Medical tests Category Transplantation medicine immunology stub ... more details
Drugbox verifiedrevid 455361647 Monoclonal antibody data type mab mab type mab source u target EpCAM Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite correct ?? CAS number 503605 66 1 ATC prefix none ATC suffix ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data C 6552 H 10080 N 1740 O 2052 S 46 molecular weight 147.5 kDa Adecatumumab MT201 is a recombinant human monoclonal antibody which is used to target tumor cells. It binds to the epithelial cell adhesion molecule EpCAM CD326 . Adecatumumab has been used in clinical studies of treatment in prostate cancer prostate ref name pmid16930989 cite journal author Oberneder R, Weckermann D, Ebner B, et al. title A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients journal Eur. J. Cancer volume 42 issue 15 pages 2530 8 year 2006 month October pmid 16930989 doi 10.1016 j.ejca.2006.05.029 url ref and breast cancer s. ref name pmid15655555 cite journal author Prang N, Preithner S, Brischwein K, et al. title Cellular and complement dependent cytotoxicity of Ep CAM specific monoclonal antibody MT201 against breast cancer cell lines journal Br. J. Cancer volume 92 issue 2 pages 342 9 year 2005 month January pmid 15655555 doi 10.1038 sj.bjc.6602310 url pmc 2361858 ref References Reflist Monoclonals for tumors Category Monoclonal antibodies for tumors monoclonal antibody stub antineoplastic drug stub it Adecatumumab ... more details
Refimprove date September 2010 Used in cytogenetics , colcemid, also known as demecolcine , is related to colchicine but it is less toxic. It depolymerization depolymerises microtubules and limits microtubule formation inactivates spindle fibre formation , thus arresting cell biology cell s in metaphase and allowing cell harvest and karyotyping to be performed. Mechanism of Action Colcemid is a microtubule depolymerizing drug like vinblastine . It acts by two distinct mechanisms. At very low concentration it binds to microtubule plus end to suppress microtubule dynamics. ref cite journal last1 Jordan first1 Mary Ann last2 Wilson first2 Leslie title Microtubules as a target for anticancer drugs journal Nature reviews. Cancer volume 4 issue 4 pages 253 65 year 2004 pmid 15057285 doi 10.1038 nrc1317 ref Recent study has found at higher concentration colcemid can promote microtubule detachment from microtubule organizing center. Detached microtubules with unprotected minus end depolymerizes with time. Cytotoxicity of the cells seems to correlate better with microtubule detachment. ref name pmid20696757 cite journal last1 Yang first1 Hailing last2 Ganguly first2 Anutosh last3 Cabral first3 Fernando title Inhibition of Cell Migration and Cell Division Correlates with Distinct Effects of Microtubule Inhibiting Drugs journal The Journal of Biological Chemistry volume 285 issue 42 pages 32242 50 year 2010 pmid 20696757 pmc 2952225 doi 10.1074 jbc.M110.160820 ref Lower concentration affects microtubule dynamics and cell migration. ref name pmid20696757 References Reflist Category Microtubule inhibitors de Demecolcin ... more details
A barrier isolator , or simply an isolator , is a device that provides a physical barrier between a laboratory technician and a work process. Isolators are routinely found within the pharmaceutical industry , and with the recent implementation of USP 797 Pharmaceutical Compounding Sterile Preparations , a set of sterile compounding standards issued by the United States Pharmacopeia , are increasingly used in pharmacy applications. They are designed to provide an isolation of a process or the maintenance of an internal condition e.g., Asepsis sterile or aseptic . Isolators may operate at positive, negative, or ambient differential atmospheric pressure pressure . Isolators may provide personnel, product, or environmental protection, or any combination thereof. They are used throughout industry, from orange juice filling lines to cytotoxicity cytotoxic drug compounding to electronics manufacturing. Regarding pharmacy applications, because people are the greatest source of contamination during aseptic manufacturing of drugs, reducing personnel interventions into the process zone has significant impact on the efficacy of the final drug product. In the mid 1980s, the industry began to employ barrier isolators, and later, in the 1990s, Restricted Access Barrier System s, or RABS, to separate people from the process. The acronym RABS was coined by Stewart Davenport of Upjohn now Pfizer . Since that time, the technology and applications of these systems has developed and broadened significantly. Major manufacturers of barrier isolators include http www.getinge.com GETINGE , http www.envair.co.uk Envair Limited , http www.machaire.co.uk Mach Aire Ltd , http www.walkerbarrier.com Walker Barrier Systems , http www.howorthgroup.com Howorth Air Technology , http www.amercare.co.uk Amercare Ltd , The Baker Company, Esco Global, and Thermo Electron Corporation. References http pharmtech.findpharma.com pharmtech Article Manufacturing High Potency Drugs Using Isolators ArticleStandar ... more details
chembox Verifiedfields changed verifiedrevid 464385520 ImageFile SN 38.svg ImageSize IUPACName OtherNames 7 Ethyl 10 hydroxy camptothecin Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 94634 InChI 1 C22H20N2O5 c1 3 12 13 7 11 25 5 6 17 13 23 19 14 12 9 24 18 19 8 16 15 20 24 26 10 29 21 27 22 16,28 4 2 h5 8,25,28H,3 4,9 10H2,1 2H3 t22 m0 s1 InChIKey FJHBVJOVLFPMQE QFIPXVFZBM ChEMBL Ref ebicite correct EBI ChEMBL 837 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C22H20N2O5 c1 3 12 13 7 11 25 5 6 17 13 23 19 14 12 9 24 18 19 8 16 15 20 24 26 10 29 21 27 22 16,28 4 2 h5 8,25,28H,3 4,9 10H2,1 2H3 t22 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey FJHBVJOVLFPMQE QFIPXVFZSA N CASNo Ref cascite changed ?? CASNo 86639 52 3 PubChem 104842 UNII Ref fdacite correct FDA UNII 0H43101T0J SMILES O C 1N4 C C C2 C 1COC O C 2 O CC c3nc5c c c3C4 CC cc O cc5 Section2 Chembox Properties Formula C sub 22 sub H sub 20 sub N sub 2 sub O sub 5 sub MolarMass 392.404 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition SN 38 is the active metabolite of irinotecan an analog of camptothecin a topoisomerase I inhibitor it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold ref http labeling.pfizer.com ShowLabeling.aspx?id 533 ref . SN38 is metabolized via glucoronidation by UGT1A1 . The variant of UGT1A1 in 10 of Caucasians which leads to poor metabolization of Irinotecan predicts Irinotecan toxicity , as it cannot be excreted from the body in its SN 38 form. SN 38 is lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by 25 of the patients administered Irinotecan . Interactive pathway map IrinotecanPathway WP229 highlight SN 38 See also NK012 , a nanodevice formulation of SN 38 References reflist Category ... more details
Drugbox verifiedrevid 447995846 IUPAC name 4 hydroxy N ,1 dimethyl 2 oxo N br phenyl 1,2 dihydroquinoline 3 carboxamide image Roquinimex.svg Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life 26 42 hours excretion Identifiers CAS number Ref cascite correct ?? CAS number 84088 42 6 ATC prefix L03 ATC suffix AX02 PubChem 55197 DrugBank Ref drugbankcite correct drugbank DrugBank UNII Ref fdacite correct FDA UNII 372T2944C0 Chemical data C 18 H 16 N 2 O 3 molecular weight 308.331 g mol Roquinimex Linomide is a quinoline derivative immunostimulant which increases Natural killer cell NK cell activity and macrophage cytotoxicity . It also inhibits angiogenesis and reduces the secretion of Tumor necrosis factor alpha TNF alpha . Roquinimex has been investigated as a treatment for some cancers including as adjuvant therapy after Hematopoietic stem cell transplantation bone marrow transplantation in acute leukemia and autoimmune diseases, such as multiple sclerosis and recent onset Diabetes mellitus type 1 type I diabetes . Several trials have been terminated due to serious cardiovascular toxicity. Immunostimulants Category Immunostimulants Category Quinolines Category Lactams Category Phenols Category Amides antineoplastic drug stub hu Rokvinimex ... more details
Staphylococcus aureus beta toxin is a toxin produced by Staphylococcus aureus . ref name pmid9054116 cite journal author Cifrian E, Guidry AJ, Bramley AJ, Norcross NL, Bastida Corcuera FD, Marquardt WW title Effect of staphylococcal beta toxin on the cytotoxicity, proliferation and adherence of Staphylococcus aureus to bovine mammary epithelial cells journal Veterinary microbiology volume 48 issue 3 4 pages 187 98 year 1996 month February pmid 9054116 doi 10.1016 0378 1135 95 00159 X url ref It is a form of sphingomyelinase ref name pmid9116505 cite journal author Gaskin DK, Bohach GA, Schlievert PM, Hovde CJ title Purification of Staphylococcus aureus beta toxin comparison of three isoelectric focusing methods journal Protein expression and purification volume 9 issue 1 pages 76 82 year 1997 month February pmid 9116505 doi 10.1006 prep.1996.0664 url http linkinghub.elsevier.com retrieve pii S1046 5928 96 90664 6 ref called sphingomyelinase C. This enzyme is toxic to a variety of cells, including erythrocytes, fibroblasts, leukocytes, and macrophages. Susceptible cells are subject to lysis of exposed sphingomyelin on their membrane surfaces. ref name isbn978 0 323 05470 6 cite book author Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller authorlink editor others title Medical Microbiology edition 6th language publisher Mosby location Philadelphia year 2009 origyear 1990 page 213 quote isbn 978 0 323 05470 6 oclc doi url accessdate ref References reflist Category Bacterial toxins Toxins ... more details
orphan date April 2010 chembox UNII Ref fdacite correct FDA UNII B5TAN0L720 verifiedrevid 442302656 ImageFile Picoplatin.png ImageSize 150px IUPACName azane 2 methylpyridine platinum 2 dichloride OtherNames Section1 Chembox Identifiers CASNo 181630 15 9 PubChem 177358 SMILES CC1 CC CC N1.N. Cl . Cl . Pt 2 Section2 Chembox Properties C 6 H 10 Cl 2 N 2 Pt 1 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Picoplatin is a Cytotoxicity cytotoxic platinum compound in clinical development by Poniard Pharmaceuticals previously NeoRx for the treatment of patients with solid tumor s ref http dx.doi.org 10.1039 C0DT00292E The status of platinum anticancer drugs in the clinic and in clinical trials Dalton Transactions ref . In Phase I and Phase II clinical trials, picoplatin demonstrated activity in a variety of solid tumors, including lung, ovarian, colorectal and hormone refractory prostate cancer. ref http www.poniard.com programs picoplatin clinical.html Picoplatin Clinical Results , Poniard Pharmaceuticals ref However, in Phase III trials, picoplatin failed to hit its primary endpoint for advanced small cell lung cancer . ref http www.fiercebiotech.com story breaking news poniard shares crash phiii picoplatin failure 2009 11 16 Poniard shares crash on Phase III picoplatin failure , fiercebiotech.com, November 16, 2009 ref Hopes are now pinned on its use for metastatic colorectal cancer ref http www.genengnews.com specialreports sritem.aspx?oid 69418732 Nov 2009 ref . References Reflist Category Alkylating antineoplastic agents Category Platinum compounds Category Organochlorides Category Pyridines antineoplastic drug stub fa ... more details
Italic title Taxobox name Haliotis midae image Haliotis midae 01.jpg image caption shell of Haliotis midae regnum Animal ia phylum Mollusca classis Gastropoda unranked superfamilia clade Vetigastropoda superfamilia Haliotoidea familia Haliotidae subfamilia genus Haliotis species H. midae binomial Haliotis midae binomial authority Carl Linnaeus Linnaeus , 1758 synonyms ref ref name WoRMS synonyms Haliotis capensis small Dunker disambiguation Dunker , 1844 small br Haliotis elatior small Pilsbury, 1890 small br Haliotis eliator small Henry Augustus Pilsbry Pilsbry , 1890 small File Abalone Haliotis midae.jpg thumb Abalone Haliotis midae Haliotis midae , known common name commonly as the South African abalone or the perlemoen abalone , is a species of sea snail , a marine gastropod mollusk in the family biology family Haliotidae , the abalone s. ref name WoRMS WRMS species 207660 Haliotis midae Linnaeus, 1758 9 April 2010 ref Subspecies Haliotis midae volcanius Patamakanthin & Eng, 2007 ref name WoRMS Description Empty section date April 2010 Distribution Haliotis midae is endemic to the waters off South Africa . ref Oliver, A.P.H. 2004 . Guide to Seashells of the World. Buffalo Firefly Books. 22 23. ref References reflist External links NCBI 36098 Haliotis midae Franchini P., van der Merwe M. & Roodt Wilding R. 2011 . Transcriptome characterization of the South African abalone Haliotis midae using sequencing by synthesis . BMC Research Notes 4 59. doi 10.1186 1756 0500 4 59 . Use dmy dates date January 2011 Roux A., Sandenbergh L. & Roodt Wilding R. 2008 . Preliminary investigation to determine the cytotoxicity of various cryoprotectants on South African abalone Haliotis midae embryos . Cryobiology 57 3. doi 10.1016 j.cryobiol.2008.09.009 . Use dmy dates date January 2011 DEFAULTSORT Haliotis Midae Category Haliotidae Haliotidae stub vi Haliotis midae ... more details
Infobox protein family Symbol Bombinin Name Bombinin image width caption solution structure of bombinin h2 in dpc micelles Pfam PF05298 Pfam clan InterPro IPR007962 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the bombinin family of antimicrobial peptides includes the bombinin and maximin protein s from Bombina maxima Giant fire bellied toad . Two groups of antimicrobial peptide s have been isolated from skin secretion s of B. maxima .Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin like peptides BLPs . Unlike BLPs, sequence variations in maximins occurred all through the molecule s. In addition to the potent antimicrobial activity, cytotoxicity against tumour cell biology cell s and spermicidal action of maximins, maximin 3 possessed a significant anti Simian HIV Human immunodeficiency virus HIV activity. Maximins 1 and 3 have been found to be toxic to mice . Peptides in the second group, termed maximins H1, H2, H3 and H4, are Homology biology homologous with bombinin H peptides. ref name pmid11835991 cite journal author Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y title Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima journal Peptides volume 23 issue 3 pages 427 435 year 2002 month March pmid 11835991 doi 10.1016 S0196 9781 01 00641 6 url ref References reflist InterPro content IPR007962 Category Protein families ... more details
Taxobox regnum Plant ae divisio Rhodophyta classis Florideophyceae ordo Gigartinales familia Rhizophyllidaceae genus Portieria species P. hornemannii binomial Portieria hornemannii binomial authority Hans Christian Lyngbye Lyngbye Paul C. Silva P.C.Silva Portieria hornemannii is a species of red algae in the family Rhizophyllidaceae . The chemical halomon was discovered in this species. ref name Fuller1 cite journal author Fuller, Richard W. Cardellina, John H., II Kato, Yoko Brinen, Linda S. Clardy, Jon Snader, Kenneth M. Boyd, Michael R. title A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines journal Journal of Medicinal Chemistry year 1992 volume 35 issue 16 pages 3007 3011 doi 10.1021 jm00094a012 pmid 1501227 ref ref name Fuller2 cite journal author Fuller, Richard W. Cardellina, John H., II Jurek, Jaroslaw Scheuer, Paul J. Alvarado Lindner, Belinda McGuire, Mary Gray, Glenn N. Steiner, Jorge Rios Clardy, Jon et al. title Isolation and structure activity features of halomon related antitumor monoterpenes from the red alga Portieria hornemannii journal Journal of Medicinal Chemistry year 1994 volume 37 issue 25 pages 4407 4411 doi 10.1021 jm00051a019 pmid 7996553 ref References reflist External links TaxonIds ncbi 128534 worms 213851 itis eol 914654 http www.algaebase.org search species detail ?species id 3543 Portieria hornemannii at AlgaeBase Category Red algae Category Plants described in 1819 Rhodophyta stub ... more details
DISPLAYTITLE In vitro toxicology In vitro toxicology testing toxicity testing is the scientific Scientific method analysis of the effects of toxic chemical substance s on cultured bacteria or mammalian cell biology cells . In vitro literally in glass testing methods are employed primarily to identify potentially hazardous chemicals and or to confirm the lack of certain toxic properties in the early stages of the development of potentially useful new substances such as therapeutic Medication drugs , agricultural chemicals and food additives. In vitro assays for xenobiotic toxicity are recently carefully considered by key government agencies e.g. EPA NIEHS NTP FDA , to better assess human risks. There are substantial activities in using in vitro systems to advance mechanistic understanding of toxicant activities, and the use of human cells and tissue to define human specific toxic effects. ref Cite web title Tox21 publisher Source U.S. Environmental Protection Agency url http www.epa.gov ncct Tox21 accessdate 2011 10 29 ref Improvement over animal testing Most toxicologists believe that in vitro toxicity testing methods can be more useful, more time and cost effective than toxicology studies in living animals which are termed in vivo or in life methods . Due to regulatory constraints and ethical considerations, the quest for alternatives to animal testing has gained a new momentum. In many cases the in vitro tests are better than animal tests because they can be used to develop safer products. ref Cite web title Vision and Roadmap for the 21st Century publisher Source National Toxicology Program url http ntp.niehs.nih.gov go vision accessdate 2011 10 29 ref Image Microtiter plate.JPG thumb A 96 well microtiter plate being used for ELISA. Example cell viability cytotoxicity assays used for In vitro toxicology Many methods of analysis exist for assaying test substances for cytotoxicity and other cellular responses. MTT MTT assay is used often in determining cell viabili ... more details
, cytotoxicity and SAR of simple geiparvarin analogues journal Anticancer Drug Des volume 12 issue 6 ... Carrara first7 M last8 Cima first8 L ref ref cite journal author Viola G title Synthesis, cytotoxicity ... more details
hemoglobin production in human CD34 cells ref and enhances antibody dependent cellular cytotoxicity ... cellular cytotoxicity ADCC mediated by trastuzumab, cetuximab and rituximab ref See also Lenalidomide ... more details
having minimum carrier cytotoxicity and the solid state of the lipid permit better controlled drug ... In vivo and cytotoxicity evaluation of repaglinide loaded binary solid lipid nanoparticles after ... more details
ligand for KIR NK cell receptors can also be differentiated based on function. Natural cytotoxicity ... for classical polymorphic MHC I molecules. NCR natural cytotoxicity receptors , upon stimulation ... in antibody dependent cell mediated cytotoxicity ADCC , in particular they bind IgG . NK cell receptors can also be differentiated based on function. Natural cytotoxicity receptors directly induce ... . Antibody Dependent Cell Mediated Cytotoxicity ADCC Infected cells are routinely opsonised ... response has been mobilized and to lysis lyse cells through Antibody dependent cellular cytotoxicity Antibody dependent cellular cytotoxicity ADCC .NK cells promote the expression of FAS on cancer cells ... cell cytotoxicity in vitro , however at a lower level than peripheral NK cells, despite containing ... pages 15563 15568 year 2005 pmcid PMC1266146 doi 10.1073 pnas.0507835102 ref . Lack of cytotoxicity ... mediated cytotoxicity against tumor target cells, both in cancer patients and animal models, investigators ... for natural or spontaneous cytotoxicity was made in the early 1970s by doctoral student Rolf ... on human B and T lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte ... were studying cell mediated cytotoxicity in normal human blood and the effect of the removal of various receptor bearing cells on this cytotoxicity. Later that same year Ronald Herberman published similar ... cytotoxicity against tumor target cells. IX. Quantitation of natural killer NK cell activity. J ... more details
cytotoxicity In vitro toxicity of single and multi walled carbon nanotubes in human astrocytoma and lung ... MW MW COOH and MW NH2 , and to assess their cytotoxicity in human astrocytoma D384 cells and lung carcinoma .... In D384 cells MTT results revealed a strong cytotoxicity 50 of SWNTs after 24 hour exposure already ... using calcein PI staining did not confirm MTT cytotoxicity data neither in D384 nor in A549 cells. The viability ... . Cytotoxicity of SWNTs and MWNTs The cytotoxicity was investigated on healthy alveolar macrophage ... cytotoxicity of SWNTs was observed in alveolar macrophage AM after a 6 hour exposure in vitro. The cytotoxicity .... No significant toxicity was observed for C60 up to a dose of 226.00 g cm2. The cytotoxicity ... structures exhibit quite different cytotoxicity and bioactivity in vitro, although they may not be accurately ... more details
Orphan date January 2011 Coramsine or Coramsine SBP002 is a chemotherapeutic and Immunomodulator immunomodulating agent whose primary ingredients are two solasodine glycoalkaloid s, solasonine and solamargine, derived from Solanum linnaeanum Devil s Apple . The use of glycoalkaloids as anti cancer agents was discovered by Queensland researcher Dr. Bill Cham in the late 1970s after hearing reports from farmers that topical application of the Devil s Apple plant was effective in slowing the growth of various skin cancers on horses and cattle. Animal studies ref cite journal author Cham BE, Gilliver M, Wilson L title Antitumour effects of glycoalkaloids isolated from Solanum sodomaeum journal Planta Med year 1987 volume 53 issue 1 pages 34 6 pmid 3575510 doi 10.1055 s 2006 962612 ref ref cite journal author Cham BE, Daunter B title Solasodine glycosides. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180. journal Cancer Lett year 1990 volume 55 issue 3 pages 221 5 pmid 2257540 doi 10.1016 0304 3835 90 90122 E ref and in vitro human trials ref cite journal author Cham BE, Daunter B title Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells journal Cancer Letters volume 55 issue 3 pages 209 20 pmid 2257539 doi 10.1016 0304 3835 90 90121 D year 1990 ref showed positive results, however Cham decided to focus his energies on developing the glycoalkaloid mixture, patented as BEC, as a topical cream for non melanoma skin cancer . ref cite journal author Cham BE, Daunter B, Evans RA title Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture BEC of solasodine glycosides. journal Cancer Lett. year 1991 volume 59 issue 3 pages 183 92 pmid 1913614 doi 10.1016 0304 3835 91 90140 D ref ref cite journal author Punjabi S, Cook LJ, Kersey P, Marks R, Cerio R title Solasodine glycoalkaloids a novel topical therapy for basal cell carcinoma. A doubl ... more details
APs compound have large spectrum of biological activity such as cytotoxicity, ichthyotoxicity, inhibition ... pronounces cytolytic, cytotoxic and antifouling activities. The most widely employed are cytotoxicity ... Almost all 3 APs compounds contains moderate cytotoxicity mechanish in concentration range of few ... more details
of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its ... methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity. See also DNA methylation ... more details
Encyclopedia
top
