- Deferasirox
licence EU Exjade license US Deferasirox Deferasirox marketed as Exjade is a Drug design Rational ... Current status of iron overload and chelation with deferasirox journal Indian J Pediatr volume 74 issue ... Choudhry ref cite journal author Yang LP, Keam SJ, Keating GM title Deferasirox a review of its use ... , renal failure and cytopenia s have been reported in patients receiving deferasirox oral suspension tablets. Properties of deferasirox Image Deferasirox iron III complex.png thumb left Two deferasirox molecules binding iron The half life of deferasirox is between 8 and 16 hours allowing once a day dosing. Two molecules of deferasirox are capable of binding to 1 atom of iron which are subsequently ... . Together with deferiprone , deferasirox seems to be capable of removing iron from cells cardiac myocytes and hepatocytes as well as removing iron from the blood. Synthesis Deferasirox can be prepared ... acid in the following two step synthetic sequence Image Deferasirox synthesis.png center Image ... acid in the presence of base to give 4 3,5 bis 2 hydroxyphenyl 1,2,4 triazol 1 yl benzoic acid Deferasirox ... 2004 issue 21 pages 4177 4192 year 2004 doi 10.1002 ejic.200400363 ref Risks Deferasirox was the 2 ... more details
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- Transfusion hemosiderosis
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 T 80 8 t 80 ICD9 ICD9 999.8 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Transfusional hemosiderosis is the accumulation of iron in the liver and or heart but also endocrine organs, in patients who receive frequent blood transfusion s such as those with thalassemia , sickle cell disease , aplastic anemia or myelodysplastic syndrome . Treatment Treatment is by phlebotomy if anemia is no more an issue, or iron chelating agent s deferoxamine , ref name pmid18360637 cite journal author Cappellini MD title Exjade R deferasirox, ICL670 in the treatment of chronic iron overload associated with blood transfusion journal Ther Clin Risk Manag volume 3 issue 2 pages 291 9 year 2007 month June pmid 18360637 doi 10.2147 tcrm.2007.3.2.291 url pmc 1936310 ref deferiprone or deferasirox . If iron overload has caused end organ damage, this is generally irreversible and may require Organ transplant transplantation . Notable patients Ted DeVita , the bubble boy , died of transfusional iron overload from too many blood transfusion s. See also Hemosiderosis References reflist medical stub Complications of surgical and medical care Category Transfusion reactions Category Complications of surgical and medical care ... more details
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- ATC code V03
ATC codes lead V 03 All other therapeutic products vet add anchor V03A V03A All other therapeutic products anchor V03AB V03AB Antidote s V03AB01 Carapichea ipecacuanha Ipecacuanha V03AB02 Nalorphine V03AB03 Edetates V03AB04 Pralidoxime V03AB05 Prednisolone and promethazine V03AB06 Thiosulfate V03AB08 Sodium nitrite V03AB09 Dimercaprol V03AB13 Obidoxime V03AB14 Protamine V03AB15 Naloxone V03AB16 Ethanol V03AB17 Methylthioninium chloride V03AB18 Potassium permanganate V03AB19 Physostigmine V03AB20 Copper sulfate V03AB21 Potassium iodide V03AB22 Amyl nitrite V03AB23 Acetylcysteine V03AB24 Digitalis antitoxin V03AB25 Flumazenil V03AB26 Methionine V03AB27 4 dimethylaminophenol V03AB29 Cholinesterase V03AB31 Prussian blue V03AB32 Glutathione V03AB33 Hydroxocobalamin V03AB34 Fomepizole V03AB35 Sugammadex V03AB36 Phentolamine QV03AB90 Atipamezole QV03AB91 Sarmazenil QV03AB92 Diprenorfin QV03AB93 Yohimbine QV03AB94 Tolazoline anchor V03AC V03AC Iron chelating agent s V03AC01 Deferoxamine V03AC02 Deferiprone V03AC03 Deferasirox anchor V03AE V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia V03AE01 Polystyrene sulfonate V03AE02 Sevelamer V03AE03 Lanthanum carbonate V03AE04 Calcium acetate magnesium carbonate Calcium acetate and magnesium carbonate anchor V03AF V03AF Detoxifying agents for antineoplastic treatment V03AF01 Mesna V03AF02 Dexrazoxane V03AF03 Calcium folinate V03AF04 Calcium levofolinate V03AF05 Amifostine V03AF06 Sodium folinate V03AF07 Rasburicase V03AF08 Palifermin V03AF09 Glucarpidase V03AF10 Sodium levofolinate anchor V03AG V03AG Drugs for treatment of hypercalcemia V03AG01 Sodium cellulose phosphate anchor V03AH V03AH Drugs for treatment of hypoglycaemia V03AH01 Diazoxide anchor V03AK V03AK Tissue adhesives anchor V03AM V03AM Drugs for embolisation anchor V03AN V03AN Medical gases V03AN01 Oxygen V03AN02 Carbon dioxide V03AN03 Helium V03AN04 Nitrogen V03AN05 Medical air anchor V03AX V03AX Other therapeutic products V03AX02 Nalfurafine anchor V03A ... more details
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- Khashayar Karimian
of Deferasirox and Deferiprone on Nickel Oxyhydroxide midified Electrode , Anal. Biochem ... of deferasirox and deferiprone on a nickel oxyhydroxide modified electrode , Anal. Biochem .... Amani, M. Saboury, A. A. The Effects of Deferiprone and Deferasirox on the Structure and Function ... more details
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- Chelation therapy
www.ftc.gov os 1998 12 9623147att.htm notification letter ref Medical use Image Deferasirox iron III complex.png thumb 275px Two molecules of deferasirox , an orally administered chelator, binding iron . Deferasirox is used in the treatment of Transfusion hemosiderosis transfusional iron overload in people ... EDTA lead poisoning ref name KatzungTrevor2008 Deferoxamine and Deferasirox acute iron poisoning ref ... more details
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- Deferiprone
Deferasirox References references Chelating agents Category Chelating agents Category Antidotes ... more details
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- Congenital dyserythropoietic anemia
undertake chelation therapy to survive either deferoxamine i.e . Desferal , deferasirox i.e. Exjade ... more details
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- Myelodysplastic syndrome
Desferal for IV use and deferasirox Exjade for oral use. These options now provide potentially useful ... a stem cell transplant. Although deferasirox is generally well tolerated other than episodes ... by the FDA and Novartis was added to deferasirox treatment guidelines. Following post marketing use of deferasirox, there were rare cases of acute kidney failure or liver failure, some resulting in death. Due to this, it is recommended that patients be closely monitored on deferasirox therapy prior ... international Phase III clinical trial is ongoing comparing treatment of deferasirox to placebo, which should help to establish the clinical value of deferasirox in iron overloaded MDS patients. Prognosis ... more details
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- List of drugs: De
List of drugs D De de dea deb deanol aceglumate International Nonproprietary Name INN Deapril ST deboxamet International Nonproprietary Name INN debrisoquine International Nonproprietary Name INN debropol International Nonproprietary Name INN dec def Deca Durabolin Decabid Decaderm decamethonium bromide International Nonproprietary Name INN Decapryn Decaspray decimemide International Nonproprietary Name INN decitabine International Nonproprietary Name INN decitropine International Nonproprietary Name INN declenperone International Nonproprietary Name INN Declomycin declopramide International Nonproprietary Name INN decloxizine International Nonproprietary Name INN decominol International Nonproprietary Name INN decoquinate International Nonproprietary Name INN dectaflur International Nonproprietary Name INN deditonium bromide International Nonproprietary Name INN deferasirox United States Adopted Name USAN deferiprone International Nonproprietary Name INN deferitrin United States Adopted Name USAN deferoxamine International Nonproprietary Name INN defibrotide International Nonproprietary Name INN Perflutren Definity deflazacort International Nonproprietary Name INN deforolimus International Nonproprietary Name INN defosfamide International Nonproprietary Name INN deg deh degarelix International Nonproprietary Name INN dehydrocholic acid International Nonproprietary Name INN dehydroemetine International Nonproprietary Name INN del Del Vi A dela dels delafloxacin United States Adopted Name USAN , International Nonproprietary Name INN Delalutin delanterone International Nonproprietary Name INN delapril International Nonproprietary Name INN Delatestryl delavirdine International Nonproprietary Name INN Delaxin Delcobese delequamine International Nonproprietary Name INN delergotrile International Nonproprietary Name INN Delestrogen delfantrine International Nonproprietary Name INN delfaprazine International Nonproprietary Name INN Delfen Delflex deligoparin sodium United ... more details
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- Binding selectivity
. Synthetic siderophores such as deferiprone and deferasirox have been developed, using the known ... more details
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- Poison
warfarin vitamin K opioids naloxone Iron and other heavy metals desferrioxamine , Deferasirox or Deferiprone ... more details
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- Iron overload
iron overload as a result are deferasirox and deferiprone . See also Human iron metabolism References ... more details
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- Beta-thalassemia
they are painful and inconvenient. The oral chelator deferasirox marketed as Exjade by Novartis ... more details
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- Thalassemia
. Deferasirox Exjade is an oral iron chelation drug also approved in the US in 2005. Deferiprone is an oral ... more details
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- Catenin
catenin. Acyl hydrazones and other iron chelators like desferrioxamine, deferasirox, and ciclopirox ... more details
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