Infobox Disease Name Demyelinatingdisease Image MS Demyelinisation CD68 10xv2.jpg Caption Photomicrograph of a demyelinating MS Lesion. Immunohistochemical staining for CD68 highlights numerous macrophages brown . Original magnification 10 . DiseasesDB ICD10 ICD10 G 35 g 35 ICD10 G 37 g 35 , ICD10 G 61 0 g 60 ICD9 ICD9 340 ICD9 341 , ICD9 357.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D003711 A demyelinatingdisease is any disease of the nervous system in which the myelin sheath of neuron s is damaged. ref DorlandsDict three 000030717 demyelinatingdisease ref This impairs the conduction of signals in the affected nerves, causing impairment in sensation, movement, cognition, or other functions depending on which nerves are involved. The term describes the effect of the disease, rather than its cause some demyelinating diseases are caused by genetics , some by infection infectious agents, some by autoimmune disorder autoimmune reactions, and some by unknown factors. Organophosphate s, a class of chemicals which are the active ingredients in commercial insecticides such as sheep dip , herbicide weed killers , and flea treatment preparations for pets, etc., will also demyelinate nerves. Neuroleptics can cause demyelination. ref cite journal author Konopaske GT, Dorph ... retrieve pii S0006 3223 07 00847 5 ref Demyelinating diseases Demyelinating diseases of the central ... inflammatory demyelinating diseases Vitamin B12 deficiency Central pontine myelinolysis Tabes Dorsalis transverse myelitis Devic s disease progressive multifocal leukoencephalopathy Optic neuritis Leukodystrophy Leukodystrophies Demyelinating diseases of the peripheral nervous system include Guillain Barr syndrome and its chronic counterpart, chronic inflammatory demyelinating polyneuropathy anti MAG peripheral neuropathy Charcot Marie Tooth Disease Copper deficiency See also Multiple sclerosis ... References reflist CNS diseases of the nervous system Demyelinating diseases of CNS PNS diseases of the nervous ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICD9 330.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D020279 A Hereditary CNS demyelinatingdisease is a demyelinatingdiseasedemyelinating central nervous system disease that is primarily due to an inherited genetic condition. This is in contrast to autoimmune demyelinating conditions, such as multiple sclerosis , or conditions such as central pontine myelinolysis that are associated with acute acquired insult. Examples include ref name urlHereditary Central Nervous System Demyelinating Diseases Genetics Home Reference cite web url http ghr.nlm.nih.gov conditionGroup hereditarycentralnervoussystemdemyelinatingdiseases title Hereditary Central Nervous System Demyelinating Diseases Genetics Home Reference format work accessdate 2009 03 11 Dead link date October 2010 bot H3llBot ref Alexander disease Canavan disease Krabbe disease leukoencephalopathy with vanishing white matter megalencephalic leukoencephalopathy with subcortical cysts metachromatic leukodystrophy X linked adrenoleukodystrophy References Reflist disease stub CNS diseases of the nervous system Category Demyelinating diseases of CNS ... more details
Infobox Disease Name CNS demyelinating autoimmune diseases Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D020278 CNS demyelinating autoimmune diseases are autoimmune disease s which primarily affect the central nervous system . Examples include Diffuse cerebral sclerosis of Schilder Acute disseminated encephalomyelitis Acute hemorrhagic leukoencephalitis Multiple sclerosis though ethiology is unknown, it is sure that immune system is involved Transverse myelitis Neuromyelitis optica See also Idiopathic inflammatory demyelinating diseases A wider group of diseases which includes also the non autoimmune demyelinating diseases. Demyelinatingdisease s Group including them all, regardless of their autoimmunity or idiopathic and inflammatory status. CNS diseases of the nervous system disease stub Category Autoimmune diseases Category Demyelinating diseases of CNS ... more details
for the acute version of this disease Guillain Barr syndrome Infobox Disease Name Chronic inflammatory demyelinating polyneuropathy Image Caption DiseasesDB 30084 ICD10 ICD9 ICD9 357.81 ICDO OMIM 139393 MedlinePlus eMedicineSubj neuro eMedicineTopic 467 MeshID D020277 Chronic inflammatory demyelinating polyneuropathy CIDP is an acquired autoimmune disorder immune mediated inflammatory disorder of the peripheral nervous system . The disorder is sometimes called chronic relapsing polyneuropathy or chronic inflammatory demyelinating poly radiculo neuropathy because it involves the nerve roots ref name radiculo . CIDP is closely related to Guillain Barr syndrome and it is considered the Chronic medical chronic counterpart of that acute medicine acute disease. Its symptoms are also similar to progressive ... of the disease is loss of the myelin sheath the fatty covering that insulates and protects nerve fibers of the peripheral nerves. Chronic inflammatory demyelinating polyneuropathy is believed to be due ... of the disease is high. CIDP is under recognized and under treated due to its heterogeneous presentation ... author Toothaker TB, Brannagan TH title Chronic inflammatory demyelinating polyneuropathies current ... left untreated despite progression of their disease. ref cite journal author Latov N title ... of treatment for inflammatory demyelinating neuropathy journal Journal of Anatomy volume 200 issue ... demyelinating polyneuropathy treated successfully with ciclosporin journal J. Neurol. Neurosurg. Psychiatr ... is lacking, mostly due to the heterogeneous nature of the disease in the patient population in addition ... As in multiple sclerosis , another demyelinating condition, it is not possible to predict with certainty ... name radiculo cite journal author Kissel JT title The treatment of chronic inflammatory demyelinating .... Because of the variability in severity and progression of the disease, doctors will not be able ... PNS diseases of the nervous system DEFAULTSORT Chronic Inflammatory Demyelinating Polyneuropathy Category ... more details
?glngUserChoice 8412 . The Medline medical dictionary defines it as a demyelinatingdisease marked ... demyelinating diseases IIDDs , sometimes known as borderline forms of multiple sclerosis , ref cite ... one disease or many? edition 2nd ref ref cite journal author Hartung HP, Grossman RI title ADEM distinct disease or part of the MS spectrum? journal Neurology volume 56 issue 10 pages 1257 60 ... outside the scope of Multiple Sclerosis and inside the scope of Devic s disease , ref cite ... 2009 pmid 19465451 doi 10.1177 1352458509104595 ref Devic s disease , currently considered a separate disease Acute disseminated encephalomyelitis or ADEM, a closely related disorder in which a known ... myelinoclastic sclerosis Schilder disease or diffuse myelinoclastic sclerosis is a rare disease that presents clinically as a pseudotumoural demyelinating lesion and is more common in children. ref cite journal author Garrido C, Levy Gomes A, Teixeira J, Temudo T title Schilder s disease two new ... SA title Myelinoclastic diffuse sclerosis Schilder s disease report of a case and review of the literature ... appearance of tumefactive demyelinating lesions journal AJR Am J Roentgenol volume 182 issue 1 ... W, Jimenez JJ, Alexander JS title Multiple sclerosis as a vascular disease journal Neurol. Res. volume ... aka Chronic fatigue syndrome ref http health.nytimes.com health guides disease chronic fatigue ... has been established, nobody can tell whether the disease dealing with is MS. Cases of MS before ... are rare before puberty, but they can happen. Whether they constitute a separate disease is still an open subject. Anyway, even this pubertal MS could be more than one disease, because early onset ... . In ICD 9 it used to say chronic disease characterized by presence of numerous areas of demyelination ... have to be considered non affected until the definition conditions are satisfied. See also Demyelinatingdisease Pathophysiology of multiple sclerosis The Myelin Project References Reflist 2 Multiple ... more details
Refimprove date February 2012 Infobox television episode Title The Disease Image File ST VOY The Disease.jpg 270px Caption Harry Kim becomes intimate with Varro scientist Tal. Series Star Trek Voyager Season 5 Episode 17 Production 210 Airdate Startdate 1999 02 24 Teleplay Michael Taylor screenwriter Michael Taylor Story Kenneth Biller Director David Livingston director David Livingston Music Dennis McCarthy composer Dennis McCarthy Guests Musetta Vander Tal Charles Rocket Jippeq Prev Dark Frontier Next Course Oblivion Star Trek Voyager Course Oblivion Episode list List of Star Trek Voyager episodes List of Star Trek Voyager episodes NOTOC for an abnormal condition affecting the body of an organism Disease The Disease is the 111th episode of Star Trek Voyager , the 17th episode of the fifth season. The episode had an average rating of 4.2 5 on the official Star Trek website as of August 23, 2007 . ref cite web publisher StarTrek.com url http www.startrek.com startrek view series VOY episode 104851.html title The Disease accessdate 2007 08 23 ref Plot Voyager stops to assist a xenophobic species known as the Varro. This species lives on a Generation ship generational ship which has housed them for 400 years. While the crew works on the Varro ship, Voyager is infested with synthetic ship eating parasites that had been released on the Varro ship by dissident Varro. Meanwhile, Harry Kim Star Trek Harry Kim becomes intimate with Varro scientist Tal, and develops a physiological bond with her, one that is standard in the Varro. The physiological connection alters his behavior and sways him from his duties aboard Voyager . It is later revealed that Tal is one of the separatists. There has been a rumour of a minority of Varro that want off the ship. The parasites that Tal helped create were made to separate the individual pods of the Varro ship without destroying the ship itself ... Star Trek DEFAULTSORT Disease, The Category Star Trek Voyager episodes Category 1999 television episodes ... more details
Charcot disease can refer to several diseases named for Jean Martin Charcot , such as Amyotrophic lateral sclerosis , a degenerative muscle disease also known as Charcot disease or Lou Gehrig s disease Charcot Marie Tooth disease , an inherited demyelinatingdisease of the peripheral nervous system Neuropathic arthropathy , progressive degeneration of a weight bearing joint, also known as Charcot joint disease or Charcot arthropathy disambig ... more details
charitable trust DEFAULTSORT Alpers Disease Category Demyelinating diseases of CNS ca S ndrome d ...Infobox Disease Name Alpers& 39 disease Image Caption DiseasesDB 29298 ICD10 ICD10 G 31 8 g 30 ICD9 ICD9 330.8 ICDO OMIM 203700 MedlinePlus eMedicineSubj eMedicineTopic MeshID D002549 Alpers disease , also called Alpers syndrome , ref name naude2004 Naud , J te Water, C M Verity, R G Will, G Devereux, and L Stellitano. 2004. http jnnp.bmj.com cgi content abstract 75 6 910 Is variant Creutzfeldt Jakob disease in young children misdiagnosed as Alpers syndrome? An analysis of a national surveillance study Journal of Neurology Neurosurgery and Psychiatry , 2004 75 910 913. Fee for full text. Retrieved on 2007 09 27. ref progressive sclerosing poliodystrophy , and progressive infantile poliodystrophy , is a progressive degenerative disease of the central nervous system that occurs mostly in infants and children. It is an autosomal recessive disorder that is sometimes seen in siblings. Alpers disease is caused by certain genetic mutations in the POLG gene. Presentation Alpers formal name is Alpers Huttenlocher syndrome AHS . First signs of the disease, which include intractable seizure s and failure to meet meaningful developmental milestones, usually occur in infancy, after the first year of life, but sometimes as late as the fifth year. Primary symptoms of the disease are developmental delay, progressive mental retardation , hypotonia low muscle tone , spasticity stiffness of the limbs ... to liver failure. While some researchers believe that Alpers disease is caused by an underlying ... for Alpers disease and, currently, no way to slow its progression. Treatment is symptomatic and supportive ... with Alpers disease is poor. Those with the disease usually die within their first decade of life ... WhoNamedIt synd 1459 Alpers disease ref References Reflist 2 Diseases of the nervous system External links http www.ninds.nih.gov disorders alpersdisease alpersdisease.htm Alpers Disease Information ... more details
Infobox disease Name Alexander disease Image Caption DiseasesDB ICD10 ICD9 ICD9 331.89 ICDO OMIM 203450 MedlinePlus eMedicineSubj eMedicineTopic MeshID D038261 Alexander disease is a slowly progressing and fatal neurodegenerative disease . It is a very rare disorder which results from a genetic mutation .... ref http www.highbeam.com doc 1P1 38896449.html MUTATION KEY TO ALEXANDER DISEASE United ... alexander Alexander Disease Gene Reviews ref ref name NINDS Clinical features Delays in development ... Alexander disease is a genetic disorder affecting the central nervous system midbrain and cerebellum ... of a parent with the disease has a 50 50 chance of inheriting the condition ref name Gene Alexander disease belongs to leukodystrophies , a group of diseases which affect growth or development of the myelin ... disorders alexander disease alexander disease.htm ref ref name BBC http news.bbc.co.uk 2 hi health 1097277.stm Cause of brain disease found BBC News ref Rosenthal fibers appear not to be present ... forms of cancer . ref name NINDS ref name Alexander The Rosenthal fibers found in Alexander disease ... The cause of Alexander disease is a mutation in the gene encoding glial fibrillary acidic protein ... HWFIG Can MR Imaging Diagnose Adult Onset Alexander Disease? AJNR ref Diagnosis It is possible to detect the signs of Alexander disease with Magnetic Resonance Imaging, which looks for specific changes in the brain that may be tell tale signs for the disease. ref name Alexander ref http www.ajnr.org ... 3470&resourcetype HWCIT Alexander Disease Diagnosis with MR Imaging AJNR ref It is even possible to detect adult onset Alexander disease with MR imaging. ref name Adult Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. ref name Alexander http www.ulf.org ... bmt journal v20 n3 abs 1700871a.html Allogeneic bone marrow transplantation for Alexander s disease ... 10 years after the onset of symptoms. Usually, the later the disease occurs, the slower its course ... more details
Infobox disease Name Canavan disease Image Caption DiseasesDB 29780 ICD10 ICD10 E 75 2 e 70 ICD9 ICD9 330.0 ICDO OMIM 271900 MedlinePlus 001586 eMedicineSubj eMedicineTopic MeshID D017825 Canavan disease , also called Canavan Van Bogaert Bertrand disease , aspartoacylase deficiency or aminoacylase 2 ..., J Moffett, Jr Madhavarao, Cn title Canavan disease and the role of N acetylaspartate in myelin ... brain brain . Canavan disease is also one of the most common degenerative cerebreal diseases of infancy. This disease is one of a group of genetic disorders called leukodystrophies . Leukodystrophies ... disease was first described in 1931 by Myrtelle Canavan . ref cite journal author Canavan MM title ... Institute The discovery of the gene for Canavan disease, and subsequent events, generated considerable controversy. In 1987 the Greenbergs, a family with two children affected by Canavan disease, donated ... of couples at risk of having a child with Canavan disease. ref name pmid10464621 cite pmid 10464621 ... in arguments about the appropriateness of patenting genes. Prevalence Although Canavan disease may ... Image autorecessive.svg thumb right Canavan disease has an autosomal recessive pattern of inheritance . Canavan disease is inherited in an autosomal recessive fashion. When both parents are carriers, there is a 25 ... for families with two parental carriers. Canavan disease is caused by a defective ASPA gene ASPA ... for efficient transmission of nerve impulses. Symptoms Symptoms of Canavan disease, which appear in early ... also occur. Treatment There is no cure for Canavan disease, nor is there a standard course of treatment ... citrate . When a person has Canavan Disease, his or her levels of N acetyl aspartate are chronically elevated. The lithium citrate has proven that, in a rat genetic model of Canavan Disease, the lithium ... with Canavan disease. ref name pmid20034825 cite pmid 20034825 ref In addition, there are experimental ... Canavan disease. ref name pmid12162821 Cite journal author Janson C et al. title Clinical protocol ... more details
Refimprove date December 2007 Infobox Disease Name Krabbe disease Image Caption DiseasesDB 29468 ICD10 ... MeshID D007965 Krabbe disease also known as globoid cell leukodystrophy ref name pmid17403939 cite ... system . This condition is inherited in an autosomal recessive pattern. The disease is named after ... disease occurs in about 1 in 100,000 births. ref name USLibraryofMedicine cite web url http ghr.nlm.nih.gov condition krabbedisease title Krabbe disease accessdate 2008 05 07 date 2008 05 02 work ... high rates of the disease, reported to be 1 in 50,000 births. ref http books.google.com ... krabbe 20disease 20sweden 2050,000&f false Books.Google.com ref Krabbe disease may also be found ... P, Amedeo S, Catalano D, Cornaglia E, Schiffer D title Krabbe s disease in two West Highland White terriers ... ref Causes Krabbe disease is caused by mutation s in the GALC gene located on chromosome chromosome ... skills. As part of a group of disorders known as leukodystrophy leukodystrophies , Krabbe disease ... degeneration in both the CNS and PNS by disrupting lipid rafts and may play a role in Krabbe disease ... 08.2009 pmid 19439584 ref Symptoms Infants with Krabbe disease are normal at birth. Symptoms ... of the disease, doctors often mistake the symptoms for those of cerebral palsy . Other symptoms include .... There are also juvenile and adult onset cases of Krabbe disease, which have similar symptoms but slower progression. Diagnosis The disease may be diagnosed by its characteristic grouping of certain ..., the disease is generally fatal before age 2. Patients with late onset Krabbe disease tend to have a slower progression of the disease and live significantly longer. Treatment Although there is no cure for Krabbe disease, bone marrow Organ transplant transplantation has been shown to benefit cases early in the course of the disease. Generally, treatment for the disorder is symptomatic and supportive ... the disease as long as they are given before overt symptoms appear. ref cite journal author ... more details
wiktionary disease A disease is an abnormal condition of an organism that impairs bodily functions and can be deadly. Disease may also refer to Disease album Disease album , a 1993 album by G.G.F.H. Disease song Disease song , a 2002 song by Matchbox Twenty disambiguation ... more details
A polycystic disease is a disease that involves multiple cysts scattered throughout an organ, including Polycystic kidney disease Polycystic liver disease Polycystic ovary syndrome disambig ... more details
Artery disease may refer to the following coronary artery disease Peripheral artery disease, more commonly called peripheral vascular disease Carotid artery disease, more commonly called carotid artery stenosis disambig ... more details
expert subject 1 Medicine date November 2011 Infobox disease Name Autoimmune diseases Image Caption DiseasesDB ... places e.g. Goodpasture s disease which may affect the basement membrane in both the lung ... which decreases the immune response. Criteria For a disease to be regarded as an autoimmune disease, it needs to answer to Witebsky s postulates first formulated by Ernst Witebsky and colleagues ... T cells Indirect evidence based on reproduction of the autoimmune disease in experimental animals ... type III , or Type IV hypersensitivity type IV . No type of autoimmune disease mimics type ... ref There is an on going discussion about when a disease should be considered autoimmune, leading ... ADEM Accepted ref name Mesh MeshName Autoimmune Diseases ref Addison s disease interferon ... liver antigen Autoimmune inner ear disease Accepted ref name urlAutoimmune Inner Ear Disease cite web url http www.bcm.edu oto grand 4893.html title Autoimmune Inner Ear Disease, Baylor College of Medicine ... polyendocrine syndrome Accepted Unknown or multiple APS 1 see Addison s disease Autoimmune progesterone ... unused data Immunology ref Autoimmune uveitis Accepted HLAB 27 ? Balo disease Balo concentric sclerosis Beh et s disease immune mediated systemic vasculitis linkage to HLA B51 HLA B27 very different manifestations with ulcers as common symptom also called Morbus Adamandiades Beh et Berger s disease ... Handbook work accessdate ref Cancer Castleman s disease Over expression of Interleukin 6 IL 6 Celiac disease Accepted ref name urlCeliac Disease cite web url http digestive.niddk.nih.gov ddiseases pubs celiac 1 title Celiac Disease format work accessdate ref ref name pmid16234635 cite journal author Meize Grochowski R title Celiac disease a multisystem autoimmune disorder journal Gastroenterol ... B title Is celiac disease an autoimmune disorder? journal Curr. Opin. Immunol. volume 17 issue 6 ... HLA DQ8 and DQ2.5 Chagas disease Suspected ref cite journal author Hyland KV, Engman DM title Further ... more details
Disease management may refer to Disease management agriculture Disease management health disambig Long comment to avoid being listed on short pages ... more details
Sir James Paget , a surgeon and pathologist, described several diseases, including Paget s disease of bone most common use of Paget s disease Paget s disease of the breast Paget Schroetter disease Extramammary Paget s disease EMPD disambig ar sl Pagetova bolezen ... more details
Still s disease can refer to Juvenile idiopathic arthritis Adult onset Still s disease disambig DEFAULTSORT Still S diSeaSe Category Connective tissue diseases pt Doen a de Still fr Maladie de Still ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D005882 A gingival disease is a disorder primarily affecting the gingiva . An example is gingivitis . disease stub Oral pathology Periodontology Category Periodontal disorders ... more details
Duroziez s disease is a congenital variant of mitral stenosis . It was described in 1877 by Paul Louis Duroziez . External links WhoNamedIt synd 2735 Duroziez disease Congenital heart defects Category Heart diseases disease stub ... more details
Infobox Disease Name Fetal disease Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D005315 Fetal disease refers to disorders originating in utero . Examples include hydrops fetalis and chorioamnionitis Medical conditions Certain conditions originating in the perinatal period Category Disorders originating in the perinatal period disease stub ... more details
mergeto Neurodegeneration discuss Talk Neurodegeneration Merger proposal date January 2012 Refimprove date December 2009 A degenerative disease , also called neurodegenerative disease, is a disease in which the function or structure of the affected biological tissue tissues or Organ anatomy organs will progressively deteriorate over time, whether due to normal bodily wear or lifestyle choices such as exercise or eating habits. ref http www.nlm.nih.gov medlineplus degenerativenervediseases.html Degenerative Nerve Diseases ref Degenerative diseases are often contrasted with infectious diseases . Examples of degenerative diseases Amyotrophic Lateral Sclerosis ALS , a.k.a., Lou Gehrig s Disease Alzheimer s disease Parkinson s Disease Multiple system atrophy Niemann Pick disease Atherosclerosis Progressive supranuclear palsy Cancer Tay Sachs Disease Diabetes Heart Disease Keratoconus Inflammatory bowel disease Inflammatory Bowel Disease IBD Prostatitis arthritis Osteoarthritis Osteoporosis Rheumatoid Arthritis Huntington s Disease Chronic traumatic encephalopathy See also Aging Disease Life extension Neurodegeneration Senescence Progressive disease References Reflist DEFAULTSORT Degenerative Disease Category Diseases and disorders ar ca Malaltia degenerativa es Enfermedad degenerativa fa fr Maladie d g n rative hr Degenerativne bolesti id Penyakit degeneratif ms Penyakit degeneratif nl Degeneratieve ziekte pl Choroby zwyrodnieniowe pt Doen a degenerativa sl Degenerativna bolezen sv Degenerativ sjukdom th zh ... more details
Disease reservoir may refer to Natural reservoir , the long term host of the pathogen of an infectious disease Fomite , any inanimate object or substance capable of carrying infectious organisms Disambig ... more details
Infobox disease Name Tooth disease Image Caption DiseasesDB ICD10 K00 K05 ICD9 ICD9 520 ICD9 525 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D014076 A tooth disease is a disorder of the tooth that can be congenital or acquired. Examples Expand section date August 2011 Congenital anodontia Acquired dental caries Medical conditions Tooth disease Category Dental disorders disease stub ... more details
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