enzyme Name deoxycytidine deaminase EC number 3.5.4.14 CAS number 37259 56 6 IUBMB EC number 3 5 4 14 GO code 0047844 image width caption In enzymology , a deoxycytidine deaminase EC number 3.5.4.14 is an enzyme that catalysis catalyzes the chemical reaction deoxycytidine H sub 2 sub O math rightleftharpoons math deoxyuridine NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are deoxycytidine and water H sub 2 sub O , whereas its two product chemistry products are deoxyuridine and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is deoxycytidine aminohydrolase . This enzyme participates in pyrimidine metabolism . References reflist 1 cite journal author Cohen SS date 1953 title Studies on controlling mechanisms in the metabolism of virus infected bacteria journal Cold Spring Harbour Symp. Quant. Biol. volume 18 pages 221&ndash 235 hydrolase stub Category EC 3.5.4 Category Enzymes of unknown structure ... more details
Unreferenced date October 2006 Chembox verifiedrevid 447288252 ImageFile 2 Desoxycytidindiphosphat.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo 800 73 7 PubChem 3972 SMILES Nc1ccn C2CC O C COP O O OP O O O O2 c O n1 MeSHName deoxycytidine diphosphate Section2 Chembox Properties Formula C sub 9 sub H sub 15 sub N sub 3 sub O sub 10 sub P sub 2 sub MolarMass 387.177 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxycytidine diphosphate is a nucleoside diphosphate . It is related to the common nucleic acid CTP, or cytidine triphosphate , with the OH hydroxyl group on the 2 carbon on the nucleotide s pentose removed hence the deoxy part of the name , and with one fewer phosphoryl group than CTP . Deoxyguanosine diphosphate would be abbreviated dCDP. See also DNA Cofactor biochemistry Cofactor Cytosine Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxycytidine Diphosphate Category Nucleotides Biochem stub ca Difosfat de desoxicitidina fa gl Desoxicitidina difosfato nl Deoxycytidinedifosfaat sr Dezoksicitidin difosfat zh ... more details
PBB geneid 1633 Deoxycytidine kinase , also known as DCK , is an enzyme which in humans is encoded by the DCK gene . ref name entrez cite web title Entrez Gene DCK deoxycytidine kinase url http www.ncbi.nlm.nih.gov ... phosphate to deoxycytidine . Function Deoxycytidine kinase DCK is required for the phosphorylation ... to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase ... phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation ... is required for productive substrate positioning in the active site of human deoxycytidine ... of human deoxycytidine kinase variants able to phosphorylate 5 substituted deoxycytidine ... M, Lavie A title Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine ... A title Elucidation of Different Binding Modes of Purine Nucleosides to Human Deoxycytidine Kinase ... deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues journal FEBS ... property of human deoxycytidine kinase explained by structures of the enzyme in complex ... 3TC and troxacitabine by human deoxycytidine kinase journal Nucleic Acids Res. volume 35 issue 1 pages ... deoxycytidine kinase cDNA journal Proc. Natl. Acad. Sci. U.S.A. volume 88 issue 4 pages 1531 5 year ..., Bergman T, et al. title Characterization of human deoxycytidine kinase. Correlation with cDNA sequences ... Expression of deoxycytidine kinase and phosphorylation of 2 chlorodeoxyadenosine in human normal and tumour ... Assignment of the human deoxycytidine kinase DCK gene to chromosome 4 band q13.3 q21.1 journal Genomics ... deoxycytidine kinase gene journal Proc. Natl. Acad. Sci. U.S.A. volume 90 issue 2 pages 431 ... S, Karlsson A title Human deoxycytidine kinase is located in the cell nucleus journal Proc. Natl. Acad ... of deoxycytidine kinase journal J. Biol. Chem. volume 273 issue 46 pages 30239 43 year 1998 ... MJ, Heemskerk MH, Honders MW, et al. title Functional role of alternatively spliced deoxycytidine ... more details
Unreferenced date December 2009 Expert subject Chemistry date November 2008 Chembox verifiedrevid 417224336 ImageFile Desoxycytidintriphosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 2056 98 6 PubChem 65091 SMILES C1C C OC1N2C CC NC2 O N COP O O OP O O OP O O O O Section2 Chembox Properties Formula C sub 9 sub H sub 16 sub N sub 3 sub O sub 13 sub P sub 3 sub MolarMass 467.156923 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxycytidine triphosphate dCTP is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction . e.g. A chemical equation can be written that represents the process DNA sub n sub dCTP DNA sub n sub C PP sub i sub That is, dCTP has the PP sub i sub pyrophosphate cleaved off and the Deoxycytidine monophosphate dCMP is incorporated into the DNA strand at the 3 end. Subsequent hydrolysis of the PP sub i sub drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain. It is stored at 20 degrees Celsius. See also DNA Replication Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxycytidine Triphosphate Category Molecular biology Category Nucleotides Biochemistry stub ca Trifosfat de desoxicitidina de Desoxycytidintriphosphat fa gl Desoxicitidina trifosfato nl Deoxycytidinetrifosfaat sr Dezoksicitidin trifosfat zh ... more details
chembox verifiedrevid 460776176 ImageFile DCMP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 13343 InChI 1 C9H14N3O7P c10 7 1 2 12 9 14 11 7 8 3 5 13 6 19 8 4 18 20 15,16 17 h1 2,5 6,8,13H,3 4H2, H2,10,11,14 H2,15,16,17 t5 ,6 ,8 m0 s1 InChIKey NCMVOABPESMRCP SHYZEUOFBL StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H14N3O7P c10 7 1 2 12 9 14 11 7 8 3 5 13 6 19 8 4 18 20 15,16 17 h1 2,5 6,8,13H,3 4H2, H2,10,11,14 H2,15,16,17 t5 ,6 ,8 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey NCMVOABPESMRCP SHYZEUOFSA N CASNo Ref cascite correct CAS CASNo 1032 65 1 ChEMBL Ref ebicite correct EBI ChEMBL 374699 PubChem 624 ChEBI Ref ebicite correct EBI ChEBI 15918 SMILES c1cn c O nc1N C H 2C C H C H O2 COP O O O O MeSHName Deoxycytidine monophosphate Section2 Chembox Properties Formula C sub 9 sub H sub 14 sub N sub 3 sub O sub 7 sub P MolarMass 307.197 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxycytidine monophosphate , also known as deoxycytidylate , or dCMP , is a deoxynucleotide , and one of the four monomer s that make up DNA . In a DNA double helix, it will base pair with deoxyguanosine monophosphate . Nucleobases, nucleosides, and nucleotides Category Nucleotides biochem stub ca Monofosfat de desoxicitidina fa fr D soxycytidine monophosphate gl Desoxicitidina monofosfato nl Deoxycytidinemonofosfaat sr Dezoksicitidin monofosfat zh ... more details
DCMP may refer to DC Motema Pembe , a football club of the Democratic Republic of the Congo Deoxycytidine monophosphate Dynamic Core Based Multicast Routing Protocol , a Multicast routing protocol disambig fr DCMP ... more details
A deoxyribonucleoside is a type of nucleoside including deoxyribose as a component. ref MeshName Deoxyribonucleosides ref An example is deoxycytidine . References reflist Nucleobases, nucleosides, and nucleotides chem stub Category Nucleosides bg fr D soxyribonucl oside ko nl Deoxyribonucleoside sr Dezoksiribonukleozid ... more details
enzyme Name dCTP diphosphatase EC number 3.6.1.12 CAS number 9024 87 7 IUBMB EC number 3 6 1 12 GO code 0047840 image width caption lowercase In enzymology , a dCTP diphosphatase EC number 3.6.1.12 is an enzyme that catalysis catalyzes the chemical reaction dCTP H sub 2 sub O math rightleftharpoons math dCMP diphosphate Thus, the two substrate biochemistry substrates of this enzyme are dCTP and water H sub 2 sub O , whereas its two product chemistry products are Deoxycytidine monophosphate dCMP and diphosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is dCTP nucleotidohydrolase . Other names in common use include deoxycytidine triphosphatase , dCTPase , dCTP pyrophosphatase , deoxycytidine triphosphatase , deoxy CTPase , and dCTPase . This enzyme participates in pyrimidine metabolism . References reflist 1 cite journal author Zimmerman SB and Kornberg A year 1961 title Deoxycytidine di and triphosphate cleavage by an enzyme formed in bacteriophage infected Escherichia coli journal J. Biol. Chem. volume 236 pages 1480&ndash 1486 pmid 13788541 Category EC 3.6.1 Category Enzymes of unknown structure hydrolase stub ... more details
enzyme Name deoxycytidylate C methyltransferase EC number 2.1.1.54 CAS number 61970 01 2 IUBMB EC number 2 1 1 54 GO code 0050003 image width caption In enzymology , a deoxycytidylate C methyltransferase EC number 2.1.1.54 is an enzyme that catalysis catalyzes the chemical reaction 5,10 methylenetetrahydrofolate dCMP math rightleftharpoons math dihydrofolate deoxy 5 methylcytidylate Thus, the two substrate biochemistry substrates of this enzyme are 5,10 Methylenetetrahydrofolic acid and Deoxycytidine monophosphate dCMP , whereas its two product chemistry products are dihydrofolic acid and deoxy 5 methylcytidylic acid . This enzyme belongs to the family of transferase s, specifically those transferring one carbon group methyltransferases. The systematic name of this enzyme class is 5,10 methylenetetrahydrofolate dCMP C methyltransferase . Other names in common use include deoxycytidylate methyltransferase , and dCMP methyltransferase . References reflist 1 cite journal author Kuo TT, Tu J date 1976 title Enzymatic synthesis of deoxy 5 methyl cytidylic acid replacing deoxycytidylic acid in Xanthomonas oryzae phage Xp12DNA journal Nature. volume 263 pages 615 pmid 980110 doi 10.1038 263615a0 issue 5578 transferase stub Category EC 2.1.1 Category Enzymes of unknown structure it Deossicitidilato C metiltransferasi ... more details
enzyme Name cytidylate kinase EC number 2.7.4.14 CAS number 37278 21 0 IUBMB EC number 2 7 4 14 GO code 0004127 image width caption In enzymology , a cytidylate kinase EC number 2.7.4.14 is an enzyme that catalysis catalyzes the chemical reaction ATP d CMP math rightleftharpoons math ADP d CDP Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and Deoxycytidine monophosphate dCMP , whereas its two product chemistry products are adenosine diphosphate ADP and dCDP . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with a phosphate group as acceptor. The systematic name of this enzyme class is ATP CMP phosphotransferase . Other names in common use include deoxycytidylate kinase , deoxycytidylate kinase , CMP kinase , CTP CMP phosphotransferase , dCMP kinase , deoxycytidine monophosphokinase , UMP CMP kinase , ATP UMP CMP phosphotransferase , and pyrimidine nucleoside monophosphate kinase . This enzyme participates in pyrimidine metabolism . Structural studies As of late 2007, 17 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1CKE , PDB link 1KDO , PDB link 1KDP , PDB link 1KDR , PDB link 1KDT , PDB link 1Q3T , PDB link 1QF9 , PDB link 1TEV , PDB link 1UKE , PDB link 2CMK , PDB link 2FEM , PDB link 2FEO , PDB link 2H92 , PDB link 2UKD , PDB link 3UKD , PDB link 4UKD , and PDB link 5UKD . References reflist 1 cite journal author Hurwitz J date 1959 title The enzymatic incorporation of ribonucleotides into polydeoxynucleotide material journal J. Biol. Chem. volume 234 pages 2351&ndash 2358 Boyer, P.D., Lardy, H. and Myrback, K. Eds. , The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 139 149. cite journal author Ruffner BW Jr, Anderson EP date 1969 title Adenosine triphosphate uridine monophosphate cytidine monophosphate phosphotransferase from Tetrahyme ... more details
enzyme Name dCTP deaminase EC number 3.5.4.13 CAS number 37289 18 2 IUBMB EC number 3 5 4 13 GO code 0008829 image width caption lowercase In enzymology , a dCTP deaminase EC number 3.5.4.13 is an enzyme that catalysis catalyzes the chemical reaction dCTP H sub 2 sub O math rightleftharpoons math dUTP NH sub 3 sub Thus, the two substrate biochemistry substrates of this enzyme are dCTP and water H sub 2 sub O , whereas its two product chemistry products are dUTP and ammonia NH sub 3 sub . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase . Other names in common use include deoxycytidine triphosphate deaminase , and 5 methyl dCTP deaminase . This enzyme participates in pyrimidine metabolism . Structural studies As of late 2007, 9 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1OGH , PDB link 1PKH , PDB link 1PKJ , PDB link 1PKK , PDB link 1XS1 , PDB link 1XS4 , PDB link 1XS6 , PDB link 2J4H , and PDB link 2J4Q . References reflist 1 cite journal author Tomita F, Takahashi I date 1969 title A novel enzyme, dCTP deaminase, found in Bacillus subtilis infected with phage PBS I journal Biochim. Biophys. Acta. volume 179 pages 18&ndash 27 pmid 4976547 issue 1 hydrolase stub Category EC 3.5.4 Category Enzymes of known structure ... more details
Drugbox Watchedfields changed verifiedrevid 450864482 IUPAC name 4 amino 1 2 deoxy b small D small erythro pentofuranosyl br 1,3,5 triazin 2 1 H one image Decitabine2.png Clinical data tradename Dacogen Drugs.com drugs.com monograph decitabine MedlinePlus a608009 pregnancy category D legal status Rx only routes of administration Intravenous therapy Intravenous Pharmacokinetic data bioavailability protein bound 1 metabolism elimination half life 30 minutes Identifiers CASNo Ref cascite correct CAS CAS number Ref cascite correct ?? CAS number 2353 33 5 ATC prefix L01 ATC suffix BC08 ATC supplemental PubChem 451668 DrugBank Ref drugbankcite correct drugbank DrugBank DB01262 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 397844 UNII Ref fdacite correct FDA UNII 776B62CQ27 KEGG Ref keggcite correct kegg KEGG D03665 ChEBI Ref ebicite correct EBI ChEBI 50131 ChEMBL Ref ebicite correct EBI ChEMBL 1201129 Chemical data C 8 H 12 N 4 O 4 molecular weight 228.206 g mol smiles O C1 N C N C N1 C H 2O C H C H O C2 CO N InChI 1 C8H12N4O4 c9 7 10 3 12 8 15 11 7 6 1 4 14 5 2 13 16 6 h3 6,13 14H,1 2H2, H2,9,11,15 t4 ,5 ,6 m0 s1 InChIKey XAUDJQYHKZQPEU KVQBGUIXBH StdInChI Ref stdinchicite correct chemspider StdInChI 1S C8H12N4O4 c9 7 10 3 12 8 15 11 7 6 1 4 14 5 2 13 16 6 h3 6,13 14H,1 2H2, H2,9,11,15 t4 ,5 ,6 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey XAUDJQYHKZQPEU KVQBGUIXSA N Decitabine trade name Dacogen , or 5 aza 2 deoxycytidine , is a cytidine analog. Mechanism It is a hypomethylating agent . ref name pmid16532500 cite journal author Kantarjian H, Issa JP, Rosenfeld CS, et al. title Decitabine improves patient outcomes in myelodysplastic syndromes results of a phase III randomized study journal Cancer volume 106 issue 8 pages 1794 803 year 2006 month April pmid 16532500 doi 10.1002 cncr.21792 ref ref name pmid12879469 cite journal author Kantarjian HM, O Brien S, Cortes J, et al. title Results of decitabine 5 aza 2 deoxycytidine therapy i ... more details
Unreferenced date December 2009 Here is a table of data skip past it to edit the text. border 1 cellpadding 2 cellspacing 0 align right style margin left 1em align center valign bottom Nitrogenous base Nucleoside Deoxynucleoside align center valign File Adenine chemical structure.png 58px Chemical structure of adenine br Adenine br File Adenosine.png 95px Chemical structure of adenosine br Adenosine br A File dA chemical structure.png 95px Chemical structure of deoxyadenosine br Deoxyadenosine br dA align center valign File Guanine chemical structure.png 86px Chemical structure of guanine br Guanine br File G chemical structure.png 123px Chemical structure of guanosine br Guanosine br G File dG chemical structure.png 123px Chemical structure of deoxyguanosine br Deoxyguanosine br dG align center valign File Thymine chemical structure.png 63px Chemical structure of thymine br Thymine br File T chemical structure.png 87px Chemical structure of 5 methyluridine br 5 Methyluridine br m sup 5 sup U File dT chemical structure.png 87px Chemical structure of thymidine br Thymidine br dT align center valign File Uracil chemical structure.png 51px Chemical structure of uracil br Uracil br File U chemical structure.png 87px Chemical structure of uridine br Uridine br U File dU chemical structure.png 87px Chemical structure of deoxyuridine br Deoxyuridine br dU align center valign File Cytosine chemical structure.png 51px Chemical structure of cytosine br Cytosine br File C chemical structure.png 87px Chemical structure of cytidine br Cytidine br C File dC chemical structure.png 87px Chemical structure of deoxycytidine br Deoxycytidine br dC Nucleosides are glycosylamine s consisting of a nucleobase often referred to as simply base bound to a ribose or deoxyribose sugar via a anomer beta Glycosidic bond glycosidic linkage . Examples of nucleosides include cytidine , uridine , adenosine , guanosine , thymidine and inosine . Biological function Nucleosides can be phosphorylation p ... more details
DAC is a three letter abbreviation with multiple uses TOCRight Culture Danish Architecture Centre Deutsche Alternative Charts , a listing of the most popular alternative albums and singles in Germany David Allan Coe , a country singer Sports Dakota Athletic Conference , an athletic conference. Daskalakis Athletic Center , the indoor sports and recreation facility for Drexel University Detroit Athletic Club , an exclusive athletic club in Detroit, MI DAC 1904 Dunajsk Streda , a slovak football team Technology Design Automation Conference , a yearly conference on electronic design automation Diamond anvil cell , an instrument used for producing very high pressures Double Acting Cylinder, a type of pneumatic cylinder Double Address Cycle , 64 bit addressing mode for DMA Digital to analog converter Discretionary Access Control is a type of access control in computer security Domain Assurance Council , a trade association started in 2006 for DKIM reputation Derived Air Concentration, a regulatory limit for radiation exposure Politics Democratic Action Congress , a political party in Trinidad and Tobago Development Assistance Committee , a sub organisation of the Organisation for Economic Co operation and Development OECD , responsible for development issues and development policies Other DAC vehicle manufacturer , a Romanian truck manufacturer Deputy Assistant Commissioner , a rank in the London Metropolitan Police Decitabine , or 5 aza 2 deoxycytidine, a DNA demethylating agent Deferred Acquisition Costs , in the insurance industry, when a company defers the sales costs that are associated with acquiring a new customer over the term of the insurance contract Districtus Austriae Controllatus , a classification for Austrian wine Star Trek DAC , a Star Trek video game Shahjalal International Airport IATA airport code DAC in Dhaka, Bangladesh Defense Ammunition Center in McAleseter, Oklahoma Mon Calamari planet Dac , the fictional Mon Calamari homeworld Department of the A ... more details
unreferenced date February 2007 Nucleoside triphosphate NTP is a molecule containing a nucleoside bound to three phosphate s. Natural nucleoside triphosphates include adenosine triphosphate ATP , guanosine triphosphate GTP , cytidine triphosphate CTP , 5 methyluridine triphosphate m sup 5 sup UTP , and uridine triphosphate UTP . These terms refer to those nucleoside triphosphates that contain ribose. The nucleoside triphosphates containing deoxyribose take prefix deoxy in their names and small d in their abbreviations deoxyadenosine triphosphate dATP , deoxyguanosine triphosphate dGTP , deoxycytidine triphosphate dCTP , deoxythymidine triphosphate dTTP and deoxyuridine triphosphate . Check the entry nucleoside for table and description of these compounds. Apart from d ATP, d GTP, d CTP, d TTP and d UTP, there are other less abundant NTPs, such as intermediates of nucleotide metabolism, but also rare natural nucleotides or even artificial nucleotides . The rare NTP are tautomeric forms of the NTPs. They cause mismatched base pairing during DNA replication. For example, a tautomeric form of cytosine is capable of forming 3 h bonds with adenine, and it will spontaneously revert to its original cytosine form, causing a mismatch. By a similar token, the deamination of cytosine leads to uracil, whereas a deamination of a commonly encountered in eukaryotes 5 methylcytosine will lead to thymine. However, the 5 to 3 DNA replication ensures that these mismatched bases are excised. Nucleotide derivatives are necessary for life, as they are building blocks of nucleic acid s and have thousands of other roles in cell metabolism and regulation. ATP is a major source of cellular energy. GTP is a very frequent cofactor of enzymes and proteins. NTPs generally provide energy and phosphate group for phosphorylations. Generally nucleoside s are nucleotide s sugar covalently bonded to a nitrogenous base, such as adenine, guanine, cytosine... that lack phosphates. However, for the sake of ... more details
Unreferenced stub auto yes date December 2009 Nucleoside analogues are a range of antiviral products used to prevent virus viral replication in infected cells. The most commonly used is Acyclovir , although its inclusion in this category is uncertain, as it contains only a partial nucleoside structure, as the pentose sugar ring is replaced by an open chain structure. Function These agents can be used against hepatitis B virus , hepatitis C virus , herpes simplex , and HIV . Once they are Phosphorylation phosphorylated , they work as antimetabolite s by being similar enough to nucleotide s to be incorporated into growing DNA strands but they act as chain terminators and stop viral DNA Polymerase. They are not specific to viral DNA and also affect mitochondrial DNA. Because of this they have side effects such as bone marrow suppression. There is a large family of reverse transcriptase inhibitor Nucleoside analog reverse transcriptase inhibitors NARTIs or NRTIs nucleoside analogue reverse transcriptase inhibitor s, because DNA production by reverse transcriptase is very different from normal human DNA replication , so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues, however, can function both as NRTIs and polymerase inhibitors for other viruses e.g., hepatitis B . Less selective nucleoside analogues are used as chemotherapy agents to treat cancer . Resistance Resistance can develop quickly with as little as one mutation. Citation needed reason an example from the literature would be nice date March 2009 Mutations occur in the enzymes that phosphorylate the drug to activate it. Examples Nucleoside analogue drugs include deoxyadenosine analogues Didanosine ddI HIV Vidarabine chemotherapy deoxycytidine analogues Cytarabine chemotherapy Emtricitabine FTC HIV Lamivudine 3TC HIV, hepatitis B Zalcitabine ddC HIV deoxyguanosine analogues Abacavir HIV Entecavir hepatitis B deoxy thymidine analogues Stav ... more details
About Buckethead s music album the enzyme Deoxycytidine kinase Infobox album See Wikipedia WikiProject Albums Name Death Cube K Type studio Artist Death Cube K Cover DCK.jpg 225px Released Jul 18 2007 limited edition br Sep 6 2007 standard edition Genre Dark Ambient br ambient music Ambient br Experimental music Experimental Length 51 28 Label TDRS Music Producer Reviews Last album Tunnel album Tunnel br 1999 This album DCK br 2007 Next album Monolith Death Cube K album Monolith br 2007 DCK is Buckethead s fourth album under the anagram Death Cube K . The limited edition started on Jul 18 2007 ref cite web url http www.tdrsmusic.com cgi bin yabb YaBB.cgi?board TDRS action display num 1184708999 title Travis Dickerson Recording Studio Forum Index publisher Tdrsmusic.com date accessdate 2012 02 12 ref and ended on Aug 24 2007. ref cite web url http www.tdrsmusic.com cgi bin yabb YaBB.cgi?board TDRS action display num 1187908342 title Travis Dickerson Recording Studio Forum Index publisher Tdrsmusic.com date accessdate 2012 02 12 ref The non limited version was available a few days later on Sep 6 2007. ref cite web url http www.tdrsmusic.com cgi bin yabb YaBB.cgi?board TDRS action display num 1189013081 title Travis Dickerson Recording Studio Forum Index publisher Tdrsmusic.com date accessdate 2012 02 12 ref Initial copies were lettered and numbered by Buckethead, but only 400 of these were made. Later CDs came without the number but with silver DCK letters. The album doesn t have an official track listing, just coming in a plain black case with no further information. ref http www.bucketheadstoystore.net DCK limited.html dead link date February 2012 ref This album is commonly mislabeled as the long awaited Torn From Black Space , released in 2009. An un official statement on the Silent Watcher Bill Laswell frequent collaborator of Buckethead and the first Death Cube K releases discography site, talked about the creation of the new label RareNoise Ltd. and the releases ... more details
phosphorylation of D and L form deoxycytidine analogue monophosphates journal Cancer research volume ... last3 Dutschman first3 GE last4 Cheng first4 YC title Phosphorylation of Cytidine, Deoxycytidine, and Their Analog ... more details
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