chembox verifiedrevid 443554948 ImageFile Cytidin.svg ImageSize 150px IUPACName 4 & x200b amino & x200b 1 & x200b 3,& x200b 4 & x200b dihydroxy & x200b 5 & x200b hydroxymethyl & x200b tetrahydrofuran & x200b 2 & x200b yl & x200b pyrimidin & x200b 2 & x200b one OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 5940 KEGG Ref keggcite correct kegg KEGG D07769 InChI 1 C9H13N3O5 c10 5 1 2 12 9 16 11 5 8 7 15 6 14 4 3 13 17 8 h1 2,4,6 8,13 15H,3H2, H2,10,11,16 t4 ,6 ,7 ,8 m1 s1 InChIKey UHDGCWIWMRVCDJ XVFCMESIBD ChEMBL Ref ebicite correct EBI ChEMBL 95606 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H13N3O5 c10 5 1 2 12 9 16 11 5 8 7 15 6 14 4 3 13 17 8 h1 2,4,6 8,13 15H,3H2, H2,10,11,16 t4 ,6 ,7 ,8 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey UHDGCWIWMRVCDJ XVFCMESISA N CASNo 65 46 3 CASNo Ref cascite correct CAS PubChem 6175 UNII Ref fdacite correct FDA UNII 5CSZ8459RP ChEBI Ref ebicite correct EBI ChEBI 17562 SMILES O C1 N C N C C N1 C H 2O C H C H O C H 2O CO MeSHName Cytidine Section2 Chembox Properties C 9 H 13 N 3 O 5 MolarMass 243.217 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring also known as a ribofuranose via a N sub 1 sub glycosidic bond . Cytidine is a component of RNA . If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine . Dietary sources of cytidine Dietary sources of cytidine include foods with high RNA ribonucleic acid content, ref name Jonas cite journal author Jonas DA, Elmadfa I, Engel KH, et al. title Safety considerations of DNA in food journal Ann Nutr Metab. volume 45 issue 6 pages 235 54 year 2001 pmid 11786646 url http content.karger.com produktedb produkte.asp?typ fulltext&file anm45235 doi 10.1159 000046734 ref such as organ meats, Brewer s yeast, as well as pyrimidine rich food ... more details
Wikify date June 2011 Drugbox Watchedfields changed verifiedrevid 443603684 IUPAC name 1 2 cyano 2 deoxy small D small arabinofuranosyl 4 palmitoylamino pyrimidin 2 1 H one image Sapacitabine.png Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 151823 14 2 ATC prefix none ATC suffix PubChem 153970 DrugBank Ref drugbankcite correct drugbank DrugBank UNII Ref fdacite correct FDA UNII W335P73C3L Chemical data C 26 H 42 N 4 O 5 molecular weight 490.64 g mol synonyms small N 1 2 R ,3 S ,4 S ,5 R 3 Cyano 4 hydroxy 5 hydroxymethyl oxolan 2 yl 2 oxopyrimidin 4 yl hexadecanamide small Sapacitabine is a drug undergoing research for potential use in chemotherapy . ref name pmid18300755 cite journal author Faderl S, Gandhi V, Kantarjian HM title Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia journal Curr. Opin. Hematol. volume 15 issue 2 pages 101 7 year 2008 month March pmid 18300755 doi 10.1097 MOH.0b013e3282f46e94 url http meta.wkhealth.com pt pt core template journal lwwgateway media landingpage.htm?an 00062752 200803000 00006 ref ref name pmid17637678 cite journal author Serova M, Galmarini CM, Ghoul A, et al. title Antiproliferative effects of sapacitabine CYC682 , a novel 2 deoxycytidine derivative, in human cancer cells journal Br. J. Cancer volume 97 issue 5 pages 628 36 year 2007 month September pmid 17637678 doi 10.1038 sj.bjc.6603896 pmc 2360357 ref Sapacitabine is an oral nucleoside analog prodrug that acts through a dual mechanism. The compound interferes with DNA synthesis by causing single strand DNA breaks and induces arrest of t ... more details
. Cytosine normally combines with a different sugar, deoxyribose , to form deoxycytidine , a component ... deoxycytidine to be incorporated into human DNA, but different enough that it kills the cell. This mechanism ... drug antiviral , cytarabine functions by inhibiting deoxycytidine use. ref name isbn0 ... more details
is a synthetic pyrimidine nucleoside analogue, structurally related to deoxycytidine , in which the 3 ... analogue. The 3 carbon of the ribose ring of 2 deoxycytidine has been replaced by a sulfur atom ... 87px Chemical structure of deoxycytidine br Deoxycytidine br style text align center ... is a deoxycytidine analogue. It is structurally related to lamivudine where the positions of the oxygen ... d4FC Elvucitabine is a deoxycytidine analogue with activity against HIV resistant to several other nucleoside ... more details
Distinguish polynucleotide phosphorylase enzyme Name purine nucleoside phosphorylase EC number 2.4.2.1 CAS number 9030 21 1 IUBMB EC number 2 4 2 1 GO code 0004731 image 1rct.png width caption purine nucleoside phosphorylase. Protein Data Bank PDB 1rct. ref Cite pmid 14706628 ref PBB geneid 4860 Purine nucleoside phosphorylase also known as PNPase and inosine phosphorylase is an enzyme that in humans is encoded by the NP gene . ref name entrez cite web title Entrez Gene NP nucleoside phosphorylase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 4860 accessdate ref Function Purine nucleoside phosphorylase is an enzyme involved in Purine Metabolism purine metabolism . PNP metabolizes adenosine into adenine , inosine into hypoxanthine , and guanosine into guanine , in each case creating ribose phosphate . Nucleoside phosphorylase is an enzyme which cleaves a nucleoside by Phosphorylation phosphorylating the ribose to produce a nucleobase and ribose 1 phosphate. It is one enzyme of the nucleotide salvage pathways. These pathways allow the cell to produce nucleotide monophosphates when the de novo synthesis de novo synthesis pathway has been interrupted or is non existent as is the case in the brain . Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin . All salvage pathway enzymes require a high energy phosphate donor such as Adenosine triphosphate ATP or PRPP . Thymidine can be phosphorylated by thymidine kinase TK . Uridine can be phosphorylated by uridine kinase UK . Cytidine can be phosphorylated by cytidine kinase CK . Deoxycytidine can be phosphorylated by deoxycytidine kinase DOK . Adenosine uses the enzyme adenosine kinase , which is a very important enzyme in the cell. Attempts are being made to develop an inhibitor for the enzyme for use in cancer chemotherapy. Enzyme Regulation This protein may use the morpheein model of allosteric regulation . ref name pmid22182754 ... more details
Drugbox Watchedfields changed verifiedrevid 443833429 IUPAC name 4 amino 1 2 deoxy 2,2 difluoro small D small erythro pentofuranosyl pyrimidin 2 1 H on image Gemcitabine.svg width 200 image2 Gemcitabine hydrochloride from xtal 3D balls.png Clinical data tradename Gemzar Drugs.com drugs.com monograph gemcitabine hydrochloride pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X D pregnancy category legal AU Unscheduled S2 S4 S8 legal UK GSL P POM CD legal US OTC Rx only legal status routes of administration Oral, intravenous Pharmacokinetic data bioavailability protein bound 10 metabolism elimination half life Short infusions 32 94 minutes br for long infusions 245 638 minutes Identifiers CASNo Ref cascite correct CAS CAS number 95058 81 4 ATC prefix L01 ATC suffix BC05 ATC supplemental PubChem 60750 DrugBank Ref drugbankcite correct drugbank DrugBank DB00441 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 54753 UNII Ref fdacite correct FDA UNII B76N6SBZ8R KEGG Ref keggcite correct kegg KEGG D02368 ChEBI Ref ebicite correct EBI ChEBI 175901 ChEMBL Ref ebicite correct EBI ChEMBL 888 Chemical data C 9 H 11 F 2 N 3 O 4 molecular weight 263.198 g mol smiles c1cn c O nc1N C H 2C C H C H O2 CO O F F InChI 1 C9H11F2N3O4 c10 9 11 6 16 4 3 15 18 7 9 14 2 1 5 12 13 8 14 17 h1 2,4,6 7,15 16H,3H2, H2,12,13,17 t4 ,6 ,7 m1 s1 InChIKey SDUQYLNIPVEERB QPPQHZFABM StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H11F2N3O4 c10 9 11 6 16 4 3 15 18 7 9 14 2 1 5 12 13 8 14 17 h1 2,4,6 7,15 16H,3H2, H2,12,13,17 t4 ,6 ,7 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey SDUQYLNIPVEERB QPPQHZFASA N Gemcitabine pronunciation jem SITE a been is a nucleoside analog used as chemotherapy . It is marketed as Gemzar by Eli Lilly and Company . Pharmacology Chemically gemcitabine is a nucleoside analog in which the hydrogen atom s on the 2 carbon of deoxycytidine are replaced by fluorine atoms. As with fluorouracil and other analogues of pyrimidines, the tr ... more details
C, Erie DA, Chen XS, Goodman MF title Structural model for deoxycytidine deaminaton mechanism ... by inducing numerous deoxycytidine to deoxyuridine mutations in the DNA Strand direction negative ... more details
PBB geneid 51455 DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene . ref name pmid10536157 cite journal author Lin W, Xin H, Zhang Y, Wu X, Yuan F, Wang Z title The human REV1 gene codes for a DNA template dependent dCMP transferase journal Nucleic Acids Res volume 27 issue 22 pages 4468 75 year 1999 month Dec pmid 10536157 pmc 148731 doi 10.1093 nar 27.22.4468 ref ref name entrez cite web title Entrez Gene REV1 REV1 homolog S. cerevisiae url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 51455 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein protein interactions. A suggested role for the human Rev1 like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis TLS of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. ref name entrez Rev1 is a DNA polymerase Family Y Y family DNA polymerase it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine dC across from lesions. Whether Guanine G , Adenine A , Thymine T , Cytidine C , or an AP site abasic site , Rev1 will always add a C. Rev1 has the ability to always add a C, because it uses an arginine as a template which complements well with C. Yet it is believed By whom date May 2011 that Rev1 rarely uses its polymerase activity, rather it is thought that Rev1 s primary role is as a protein landing pad, whereby it helps direct the recruitment of TLS proteins, especially Pol REV3L Rev3 Rev7 . Interactions REV1 has been shown to Protein protein interaction interact with MAD2L2 . ref name pmid11485998 cite journal last Murakumo first Y authorlink coauthors Og ... more details
author Wijermans P, L bbert M, Verhoef G, et al. title Low dose 5 aza 2 deoxycytidine, a DNA ... methylation inhibitor 5 aza 2 deoxycytidine journal Br. J. Haematol. volume 114 issue 2 pages ... more details
For other categories, see List of MeSH codes . This is the fourth part of the list of the D codes for MeSH . It is a product of the United States National Library of Medicine . Source for content is http www.nlm.nih.gov mesh filelist.html here . File 2006 MeSH Trees . MeshNumber D08 Enzymes and Coenzymes enzymes and coenzymes MeshNumber D08.211 Coenzymes coenzymes MeshNumber D08.211.090 Biopterin biopterin MeshNumber D08.211.090.500 Neopterin neopterin MeshNumber D08.211.096 Biotin biotin MeshNumber D08.211.175 Cobamides cobamides MeshNumber D08.211.211 Coenzyme A coenzyme a MeshNumber D08.211.211.300 Acyl Coenzyme A acyl coenzyme a MeshNumber D08.211.211.300.075 Acetyl Coenzyme A acetyl coenzyme a MeshNumber D08.211.211.300.500 Malonyl Coenzyme A malonyl coenzyme a MeshNumber D08.211.211.300.700 Palmitoyl Coenzyme A palmitoyl coenzyme a MeshNumber D08.211.474 Flavins flavins MeshNumber D08.211.474.650 Riboflavin riboflavin MeshNumber D08.211.474.650.249 Flavin Adenine Dinucleotide flavin adenine dinucleotide MeshNumber D08.211.474.650.500 Flavin Mononucleotide flavin mononucleotide MeshNumber D08.211.589 NAD nad MeshNumber D08.211.625 NADP nadp MeshNumber D08.211.682 PQQ Cofactor pqq cofactor MeshNumber D08.211.740 Pyridoxal Phosphate pyridoxal phosphate MeshNumber D08.211.790 Sphingolipid Activator Proteins sphingolipid activator proteins MeshNumber D08.211.790.249 G M2 Activator Protein g m2 activator protein MeshNumber D08.211.790.500 Saposins saposins MeshNumber D08.211.840 Tetrahydrofolates tetrahydrofolates MeshNumber D08.211.840.300 Formyltetrahydrofolates formyltetrahydrofolates MeshNumber D08.211.840.300.500 Leucovorin leucovorin MeshNumber D08.211.878 Thiamine Pyrophosphate thiamine pyrophosphate MeshNumber D08.211.906 Thioctic Acid thioctic acid MeshNumber D08.211.935 Ubiquinone ubiquinone MeshNumber D08.244 Cytochromes cytochromes MeshNumber D08.244.175 Cytochrome a Group cytochrome a group MeshNumber D08.244.175.249 Cytochromes a cytochromes a MeshNumb ... more details
Encyclopedia
top
