protein Name deoxyribonucleaseII alpha caption image width HGNCid 2960 Symbol DNASE2 AltSymbols DNASE2A, DRN2, DNL, DNL2 EntrezGene 1777 OMIM 126350 RefSeq NM 001375 UniProt O00115 PDB ECnumber 3.1.22.1 Chromosome 19 Arm p Band 13.2 LocusSupplementaryData protein Name deoxyribonucleaseII beta caption image width HGNCid 28875 Symbol DNASE2B AltSymbols EntrezGene 58511 OMIM 608057 RefSeq NM 021233 UniProt Q8WZ79 PDB ECnumber 3.1.22.1 Chromosome 1 Arm p Band 22.3 LocusSupplementaryData DeoxyribonucleaseII , or Acid DNase , hydrolyzes deoxyribonucleotide linkages in native and denatured DNA , yielding products with 3 phosphates. As the name implies, it is more effective at acid pH . There are several known DNase s II, including DNase II alpha usually just called DNase II DNase II beta also called DLAD, or DNase II Like Acid DNase External links MeshName deoxyribonucleaseII Nucleases Category EC 3.1.21 hydrolase stub ... more details
Image DNase1.jpg thumb right Crystals of DNase protein. A deoxyribonuclease DNase , for short is any enzyme that catalyzes the hydrolysis hydrolytic cleavage of phosphodiester bonds phosphodiester linkages in the DNA backbone. Thus, deoxyribonucleases are one type of nuclease . A wide variety of deoxyribonucleases are known, which differ in their substrate biochemistry substrate specificities, chemical mechanisms, and biological functions. Modes of action Some DNases cleave only residues at the ends of DNA molecules exodeoxyribonuclease s, a type of exonuclease . Others cleave anywhere along the chain endodeoxyribonuclease s, a subset of endonuclease s . Some are fairly indiscriminate about the DNA sequence at which they cut, while others, including restriction enzyme s, are very sequence specific. Some cleave only double stranded DNA others are specific for single stranded molecules and still others are active toward both. DNase enzymes can be inhaled using a nebuliser by cystic fibrosis sufferers. DNase enzymes help because white blood cells accumulate in the mucus, and, when they break down, they release DNA, which adds to the stickiness of the mucus. DNase enzymes break down the DNA, and the mucus is much easier to clear from the lungs. Types of deoxyribonucleases The two main types of DNase found in metazoans are known as deoxyribonuclease I and deoxyribonucleaseII . Other types of DNase include Micrococcal nuclease . Assay of deoxyribonucleases DNA absorbs UV light with a wavelength of maximal absorbance near 260 nm. This absorption is due to the pi electrons in the aromatic bases of the DNA. In dsDNA, or even regions of RNA where double stranded structure occurs, the bases are stacked parallel to each other, and the overlap of the base molecular orbitals leads to a decrease in absorbance of UV light. This phenomenon is called the hyperchromic effect. When DNAse liberates nucleotides from dsDNA, the bases are no longer stacked as they are in dsDNA, so that orbital ... more details
Deoxyribonuclease IV is a type of deoxyribonuclease that functions at AP sites. See also phage T4 External links MeshName Deoxyriboendonuclease IV EC number 3.1.21.2 cite journal author Lindahl T, Gally JA, Edelman GM title Deoxyribonuclease IV a new exonuclease from mammalian tissues journal Proc. Natl. Acad. Sci. U.S.A. volume 62 issue 2 pages 597 603 year 1969 pmid 5256235 doi 10.1073 pnas.62.2.597 pmc 277851 Nucleases hydrolase stub biochem stub Category EC 3.1.21 ... more details
PBB geneid 1773 Deoxyribonuclease I usually called DNase I , is an endonuclease coded by the human gene DNASE1 . ref name entrez cite web title Entrez Gene DNASE1 deoxyribonuclease I url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1773 accessdate ref DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide , yielding 5 phosphate terminated polynucleotides with a free hydroxyl group on position 3 , on average ... . In addition to its role as a waste management endonuclease , it has been suggested to be one of the deoxyribonuclease ... Human genetically polymorphic deoxyribonuclease purification, characterization, and multiplicity of urine deoxyribonuclease I journal J. Biochem. volume 108 issue 3 pages 393 8 year 1991 pmid 2277032 doi cite journal author Kishi K, Yasuda T, Ikehara Y, et al. title Human serum deoxyribonuclease ... deoxyribonuclease I journal Hum. Genet. volume 81 issue 3 pages 295 7 year 1989 pmid 2921043 doi ... derived interleukin 1 inhibitor. Homology with deoxyribonuclease I journal J. Exp. Med. volume 168 ... deoxyribonuclease I polymorphism journal Ann. Hum. Genet. volume 59 issue Pt 2 pages 139 47 year 1995 ... Y, Yoshida A title Structure of the human deoxyribonuclease I DNase I gene identification of the nucleotide ... author Yasuda T, Nadano D, Iida R, et al. title Chromosomal assignment of the human deoxyribonuclease ... of human deoxyribonuclease I identification of the nucleotide substitution that generates the fourth ... 5793 95 00037 A cite journal author Yasuda T, Nadano D, Tenjo E, et al. title Genotyping of human deoxyribonuclease ... polymorphic site in human deoxyribonuclease I DNase I journal Hum. Genet. volume 98 issue ... M, et al. title The fifth allele of the human deoxyribonuclease I DNase I polymorphism journal ... cite journal author Yasuda T, Takeshita H, Iida R, et al. title A new allele, DNASE1 6, of human deoxyribonuclease ... pmid 12005024 doi 10.1023 A 1014999624430 refend External links MeshName deoxyribonuclease I Nucleases ... more details
Ii or ii can refer to ii digraph , a digraph in certain romanized alphabets Ii, Finland , a municipality of Finland Ii is a Japanese surname, daimyo of Hikone Ii clan , Japanese clan Sengoku period Ii Naomasa , one of four Guardians of the Tokugawa clan Naoyuki IiIi Naoyuki , a Japanese author iiNet , a major Australian Internet service provider trading as simply ii 2 number , in lowercase Roman numerals Illegal immigrant especially in Hong Kong vernacular Invariant chain ii IRC client , short for IRC It, an Internet Relay Chat client for Unix like operating systems John Papa , Hawaiian noble Yi language ISO 639 alpha 2, ii Supertonic , in music See also II disambiguation disambig Category Surnames eo Ii no Ii pt II fi Ii t smennyssivu ... more details
Refimprove date July 2009 Infobox rocket stage name S II image ap6 MSFC 6758331.jpg caption The Apollo 6 S II stage during stacking operations in the Vehicle Assembly Building VAB manufacturer North American ... LH2 The S II pronounced ess two was the second stage of the Saturn V rocket. It was built by North ... building in Seal Beach, CA The beginning of the S II came in December 1959 when a committee recommended ... time the S II stage design began to take shape. Initially it was to have four J 2 engines and be 22.5 ... second stage.jpg left thumb Cutaway illustration of the S II second stage When fully loaded with propellant, the S II had a mass of about 481 tonne s. The hardware was only 7.6 of this 92.4 was liquid ... like the S IC , the S II used a common bulkhead that included both the top of the LOX tank and bottom .... The final method was to spray insulation on by hand and trim the excess. The S II was constructed ... efefef Current location style background efefef Notes S II F Used as Dynamic Test Stage replacement after destruction of S II S D and S II T At the U.S. Space & Rocket Center , Huntsville, Alabama Huntsville , Alabama br coord 34.710544 86.657185 format dms type landmark region US AL name S II F S II T Destroyed in explosion May 28, 1966 fact date January 2012 S II D Construction canceled S II S D Structural and Dynamic Test Vehicle Destroyed in test stand September 29, 1965 S II 1 Apollo 4 November 9, 1967 coord 32 12 N 39 40 W name S II 1 fact date January 2012 Carried Camera Targets spaced around the forward skirt and carried cameras to record first stage separation S II 2 Apollo 6 April 4, 1968 carried cameras to record first stage separation S II 3 Apollo 8 December 21, 1968 coord 31 50 N 38 0 W name S II 3 fact date January 2012 S II 4 Apollo 9 March 3, 1969 coord 31 28 N 34 2 W name S II 4 fact date January 2012 1800 kg lighter allowing 600 kg more payload, more powerful engines and carried more LOX S II 5 Apollo 10 May 18, 1969 coord 31 31 N 34 31 W name S II 5 fact ... more details
Anastasius II or Anastasios II could refer to Anastasios II emperor Pope Anastasius II disambiguation bg II fr Anastase II gl Anastasio II hr Anastazije II. it Anastasio II he la Anastasius II fi Anastasius II ... more details
Class II may refer to Class II antiarrhythmic Class II appliance Class II bacteriocin Class II cabinet Class II gene Class II PI 3 kinases Class II railroad Class II star MHC class II dab Long comment to avoid being listed on short pages ... more details
Ramiro II may refer to Ramiro II of Le n died 951 Ramiro II of Aragon died 1157 hndis an Remiro II ca Ramir II es Ramiro II fr Ramiro II gl Ramiro II pt Ramiro II ru II ... more details
Alexius II may refer to Alexius II Comnenus 1167 1183 , Byzantine Emperor Alexius II of Trebizond 1297 1330 , Emperor of Trebizond Patriarch Alexius II 1990 2008 , Patriarch of Moscow and All Russia hndis Alexius II de Alexios II. fr Alexis II it Alessio II la Alexius II nl Alexius II pl Aleksy II pt Alexis II ru II ... more details
Gerard II may refer to Gerard II, Count of Guelders from 1129 to 1131 Gerard II of Isenburg Kempenich co Lord in 1329 1330 hndis Gerard II fr G rard II ... more details
Isabel II can refer to Queen Isabella II of Spain Spanish cruiser Isabel II Isabel II , a Spanish cruiser that fought in the Spanish American War. Queen Elizabeth II of the United Kingdom disambig an Isabel II ast Sabela II ca Isabel II ceb Isabel II es Isabel II eu Isabel II.a gl Isabel II hu II. Izabella egy rtelm s t lap ... more details
Odo II may refer to Odo II, Count of Troyes 9th century Odo II, Count of Blois 983 1037 Odo II, Margrave of the Saxon Ostmark d. 1046 hndis Odo II it Oddone II ... more details
wiktionary II distinguish LL disambiguation II is the Roman numeral for 2 number two . This may also refer to Music II The Presidents of the United States of America album II The Presidents of the United States of America album , 1996 II Boyz II Men album II Boyz II Men album , 1994 II 2 Unlimited album II 2 Unlimited album , 1998 II Espers album II Espers album , 2006 II Krux album II Krux album , 2006 II Hardline album II Hardline album , 2002 Viva Koenji , Koenji Hyakkei album, also known as IIII Maylene and the Sons of Disaster album II Maylene and the Sons of Disaster album , 2007 II Kingston Wall album II Kingston Wall album , 1993 II Darna album II Darna album , 2003 II The Kinleys album II The Kinleys album , 2000 II Charade album II Charade album , 2004 Led Zeppelin II , 1969 Meat Puppets II , 1984 Two Cursed album II Cursed album , 2005 Miscellanea II, the IBC Airways IATA airline designator Immortality Institute Institutional Investor Magazine , an American magazine Image intensifier , medical imaging equipment Index Islamicus Internet Infidels , discussion forum Internationalization Index , used by the UN to rank nations and companies in evaluating their degree of integration with the world economy Optic nerve , 2nd cranial nerve See also Ii disambiguation disambiguation cs II de II es II eo Ii fr II ko II it II sw II lt II ja II no Ii pl II pt II ru II fi Ii t smennyssivu ... more details
George II may refer to George II of Abkhazia 916 960 George II of Georgia 1072 1089 Yuri II of Vladimir or George II 1212 1216, 1218 1237 George II of Bulgaria 1321 1322 George II, Prince of Anhalt Dessau 1454 1509 George II of Kakheti 1511 1513 George II of Imereti 1565 1585 George II, Landgrave of Hesse Darmstadt 1605 1661 George II of Great Britain 1683 1760 George Tupou II of Tonga 1874 1918 He s really Tupou II, not George II, but it does no harm having him here. George II of Greece 1890 1947 See also ura II , of Zeta died 1403 GEORGE 2, a version of GEORGE operating system hndis George II ca Jordi II de Liste der Herrscher namens Georg Georg II. es Jorge II fr Georges II it Giorgio II he ka II hu II. Gy rgy egy rtelm s t lap nl George II ja 2 pl Jerzy II ru II sk Juraj II. fi Yrj II sv Georg II tr II. George uk II zh ... more details
Alfonso II may refer to Alfonso II of Asturias 791 842 Alfonso II of Aragon 1162 1196 Afonso II of Portugal 1185 1223 , the Fat Alfonso, Count of Poitou 1220 1271 , jure uxoris Alfonso II, Count of Toulouse Alfonso II of Naples 1448 1495 Alfonso II d Este 1533 1597 , duke of Ferrara from 1559 to 1597 hndis an Alifonso II ca Alfons II de Liste der Herrscher namens Alfons Alfons II. es Alfonso II fr Alphonse II gl Afonso II ko 2 it Alfonso II ka II lv Alfonso II hu II. Alfonz egy rtelm s t lap nl Alfons II ja 2 pl Alfons II pt Afonso II ru II fi Alfonso II sv Alfons II zh ... more details
Baldwin II may refer to Baldwin II of Flanders c. 865 918 Baldwin II of Boulogne c. 990 c. 1033 Baldwin II, Count of Hainaut 1056 1098 Baldwin II of Jerusalem , King of Jerusalem died 1131 Baldwin II of Constantinople , Latin Emperor of Constantinople 1217 1273 hndis Baldwin II cs Balduin II. de Liste der Herrscher namens Balduin Balduin II. es Balduino II fr Baudouin II ko 2 it Baldovino II he lt Balduinas II reik m s hu II. Balduin egy rtelm s t lap nl Boudewijn II ja 2 pl Baldwin II ru II ... more details
Philip II may refer to People Philip II of Macedon 382 336 BC Philip II Philoromaeus 65 64 BC Philip II of France 1165 1223 Philip II of Navarre 1293 1322 Philip II of Taranto 1329 1374 Philip II, Duke of Burgundy 1342 1404 Philip II, Duke of Savoy 1438 1497 Philip II of Spain 1527 1598 Philip II of Portugal 1578 1621 Philippe II, Duke of Orl ans 1674 1723 Other Philip II Hospital , Republic of Macedonia disambig hn ar an Felipe II ast Felipe II bg II bs Filip II vor br Fulup II cs Filip II. da Filip 2. de Liste der Herrscher namens Philipp Philipp II. es Felipe II desambiguaci n fa fr Philippe II hr Filip II. id Philip II it Filippo II he la Philippus II lv Filips II lt Pilypas I hu II. F l p egy rtelm s t lap nl Filips II nds nl Filips II ja 2 no Filip II pl Filip II ro Filip al II lea ru II simple Philip II sk Filip II. sr II sh Filip II fi Filip II sv Filip II tr II. Filip uk II vi Philip II vls Filips II zh ... more details
Frederick II may refer to Frederick II, Duke of Swabia 1090 1147 Frederick II, Holy Roman Emperor 1194 1250 , king 1211 12 1250, emperor from 1220 Frederick II of Austria died 1246 , Duke of Austria 1230 1246 Frederick III of Sicily 1272 1337 Frederik II van Sierck died 1322 , bishop of Utrecht Frederick II, Elector of Saxony 1412 1464 Frederick II, Margrave of Brandenburg 1413 1470 , margrave 1440 1470 Frederick II, Elector Palatine 1482 1556 , elector 1544 1556 Frederick II of Denmark and Norway 1534 1588 , king 1559 1588 Frederick II, Duke of Saxe Gotha Altenburg 1676 1732 Frederick II, Landgrave of Hesse Cassel 1720 1785 Frederick II of Prussia 1712 1786 , king 1740 1786, better known as Frederick the Great Frederick II, Duke of Mecklenburg Schwerin 1717 1785 Frederick II, Duke of Anhalt 1856 1918 hndis name Frederick II an Frederico II br Frederig II bg II cs Fridrich II. cy Ffrederic II de Friedrich II. es Federico II fa fr Fr d ric II ko 2 hr Fridrik II. is Fri rik 2. it Federico II disambigua he lv Fr drihs II lt Frydrichas II hu II. Frigyes egy rtelm s t lap ro Frederic II nl Frederik II ja 2 no Fredrik II pl Fryderyk II pt Frederico II ru II scn Fidiricu II disambiguitati sk Fridrich II. sl Friderik II. fi Fredrik II sv Fredrik II uk II vi Frederick II zh ... more details
Conrad II may refer to Conrad II, Holy Roman Emperor c. 990 1039 Conrad II, Duke of Transjurane Burgundy floruit fl. 858 864 Conrad II of Znojmo Conrad II of Bohemia died 1191 Conrad II of Dachau died 1159 Conrad II of Italy 1074 1101 Conrad II of Jerusalem 1228 1254 Conrad II of Teck 1235 1292 Conrad II, Duke of Carinthia probably 1003 1039 Conrad II the Hunchback hndis Conrad 02 ca Conrad II cs Konr d II. rozcestn k et Konrad II fr Conrad II pl Konrad II ... more details
Maximilian II may refer to Maximilian II of Burgundy 1514 1558 Maximilian II, Holy Roman Emperor 1527 1576 Maximilian II Emanuel, Elector of Bavaria 1662 1726 Maximilian II of Bavaria 1811 1864 hndis Maximilian II br Masimilian II bg II cs Maxmili n II. de Maximilian II. et Maximilian II ko 2 it Massimiliano II lv Maksimili ns II nl Maximiliaan II ja 2 pt Maximiliano II sv Maximilian II zh ... more details
Boleslaus II Boleslav II, Boleslaw II, Boles aw II may refer to Boleslaus II of Bohemia died 999 Boleslaus II of Poland ca. 1041 or 1042 1081 or 1082 Boles aw II of Cieszyn ca. 1425 28 1452 Boles aw II the Bald Boleslaus II of Masovia See also Boleslaus disambiguation , other kings of this name hndis bs Boleslav II vor cs Boleslav II. rozcestn k it Boleslao II lv Bo eslavs II nl Boleslav II pl Boles aw II sv Boleslav II ... more details
Andronikos II may refer to Andronikos II Palaiologos 1259 1260 1332 , Byzantine Emperor Andronikos II of Trebizond c. 1240 1266 , Emperor of Trebizond hndis nl Andronikos II ... more details
Cotys II or Kotys II can refer to two kings of Thrace Cotys II Odrysian , ruled ca. 300 280 BC Cotys II Sapaean , ruled 42 15 BC hndis ... more details
Charles II may refer to Charles the Bald 823 877 , king of the West Franks and Holy Roman Emperor Charles II of Naples 1248 1309 Charles II of Alen on 1297 1346 Charles II of Navarre 1332 1387 Charles II, Duke of Lorraine 1390 1431 Charles II, Duke of Bourbon 1434 1488 Charles II, Duke of Savoy 1489 1496 Charles II, Archduke of Inner Austria 1540 1590 Charles II, Duke of Mantua and Montferrat 1637 1665 Charles II of England , Ireland & Scotland 1630 1685 Charles II, Elector Palatine 1651 1685 Charles II of Spain 1661 1700 Charles VI, Holy Roman Emperor , also known as Charles II of Bohemia, 1685 1740 Charles de Secondat, baron de Montesquieu 1689 1755 , French political philosopher of the Enlightenment era Charles II, Grand Duke of Mecklenburg Strelitz 1741 1816 Charles XIII of Sweden Charles II of Norway also known as Charles XIII of Sweden 1748 1818 Charles VIII of Sweden Charles II of Sweden , usually called Charles VIII Landgrave Charles of Hesse Kassel 1744 1836 Charles II, Duke of Parma 1799 1883 Carol II of Romania 1893 1953 hndis Charles 02 ast Carlos II bg II ca Carles II cs Karel II. rozcestn k cy Siarl II et Charles II t psustus es Carlos II fa fr Charles II it Carlo II lt Karolis II hu II. K roly egy rtelm s t lap nl Karel II ja 2 nn Karl II pl Karol II pt Carlos II ru II sk Karol II. sl Karel II. fi Kaarle II sv Karl II uk II vls Karel II zh ... more details
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