- Deoxyribozyme
3 which acts as a deoxyribozyme that uses light to repair a thymine ... pubmed 14691255?dopt Abstract title A deoxyribozyme that harnesses light to repair thymine dimers ... ref . ref cite web url http intl.pnas.org content 101 1 65.full title A deoxyribozyme that harnesses ... MeshName Deoxyribozyme Category DNA ... more details
|
- Dz13
Dz13 is an experimental treatment developed by Australia n scientists which aims to combat a range of illnesses from diabetes to Heart Disease heart disease and cancer . How it works Dz13 is a Deoxyribozyme DNAzyme that targets c Jun , a transcription factor found in diseased blood vessels, eyes, lungs and joints. The treatment works by destroying RNA , essentially inhibiting c Jun expression in cells. ref name Dass2008 The potential of Dz13 as a therapeutic derives from the fact that inactivation of c Jun can have an effect on Upstream and downstream transduction downstream gene genes such as MMP 2 , MMP 9 , VEGF and FGF 2 . ref name Fahmy2006 Dz13 in cancer Dz13 has been shown to inhibit tumour growth and angiogenesis . ref name Fahmy2006 Anti cancer effects have been demonstrated in models of prostate cancer , breast cancer and osteosarcoma . ref name Tan2010 Clinical trials of Dz13 in patients with skin cancer basal cell carcinoma commenced in 2010. ref name ACT2010 References Reflist refs ref name Dass2008 Dass, C.R. et al 2008 . DNAzyme technology and cancer therapy cleave and let die. Mol Cancer Ther. 7 2 243 51. ref ref name Fahmy2006 Fahmy, R. et al 2006 . Suppression of vascular permeability and inflammation by targeting of the transcription factor c Jun. Nat Biotechnol. 24 7 856 863. ref ref name Tan2010 Tan, M.L. et al 2010 . Direct anti metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP 2, MMP 9 and MT1 MMP in tumours. Cancer Cell Int. 10 9. ref ref name ACT2010 Australian Cancer Trials 2010 . A phase I study of the Dz13 drug targeting the c Jun gene in subjects with skin cancer nodular basal cell carcinoma . http www.australiancancertrials.gov.au search clinical trials search results clinical trials details.aspx?TrialID 335133&ds 1 . ref External links http www.smh.com.au news National New super drug may combat cancer 2006 07 03 1151778858991.html New super drug may combat cancer Category Experimental medical treatments ... more details
|
- MAYA-II
gates are made of the E6 Deoxyribozyme s or DNAzyme which react to specific oligonucleotide input ... more details
|
- Metal Ions in Life Sciences
Metal Coordination Deoxyribozyme Enantioselective catalysis at the DNA Scaffold G quadruplex G Quadruplexes ... more details
|
- Ribozyme
month May pmid 16426595 doi 10.1016 j.cca.2005.11.023 url issn ref See also colbegin 2 Deoxyribozyme ... more details
|
- DNA computing
DNA deoxyribozyme or DNAzyme catalyze a reaction when interacting with the appropriate input, such as a matching ... more details
|
- DNA nanotechnology
In addition, reconfigurable structures and devices can be made using functional nucleic acids such as deoxyribozyme ......4.1203S ref Another approach is to make use of restriction enzyme s or deoxyribozyme s to cleave ... more details
|
Encyclopedia
top
