Infobox disease Name Dermatomyositis Image Dermatomyositis high mag.jpg Caption Micrograph of dermatomyositis ... mult eMedicine2 derm 98 MeshID D003882 Dermatomyositis DM is a connective tissue disease related ... article 332783 overview work Medscape reference accessdate 22 April 2012 date 12 Oct 2011 title Dermatomyositis ... . Many people diagnosed with dermatomyositis were previously diagnosed with infectious mononucleosis and Epstein Barr virus . Some cases of dermatomyositis actually overlap are combined with other autoimmune ... . Because of the link between dermatomyositis and autoimmune disease, doctors and patients suspecting dermatomyositis may find it helpful to run an Anti nuclear antibody ANA antinuclear antibody test ... and dermatomyositis were reported as being triggered by the use of various statin drugs used .... Confirmed polymyositis with the skin signs is known as dermatomyositis which amplifies the problem to various cancers Clarify date August 2011 . Some cases of dermatomyositis are a paraneoplastic phenomenon ... NS title Ulcerative paraneoplastic dermatomyositis secondary to metastatic breast cancer journal Skinmed ... pre existent, with removal of the cancer resulting in remission of the dermatomyositis. The onset ... myositis does not differ from that seen in polymyositis or dermatomyositis. All of these histologic ... of hand interphalangeal joints in a patient with juvenile dermatomyositis. Image XRaydermatomyositis.jpg thumb right X Ray of the knee in a patient with dermatomyositis. X ray findings sometimes ... Interstitial lung disease ILD in polymyositis and dermatomyositis by Maryann Fathi and Ingrid E Lundberg ... manifestation in patients with polymyositis or dermatomyositis and because ILD is associated ... including DAD, UIP, neutrophil alveolitis, digital infarcts showing microangiopathy in dermatomyositis, and amyopathic dermatomyositis have all been reported as risk factors for poor outcome. Presence ... monitoring of lung function. Classification Dermatomyositis is a type of autoimmune connective ... more details
Merge Juvenile dermatomyositis date May 2010 Childhood dermatomyositis is a connective tissue disease related to polymyositis , characterized by inflammation of the muscles and the skin. It differs from adult dermatomyositis in several ways, and has two common variants. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. Page 169. ISBN 0 7216 2921 0. ref The more common form is the Brunsting type, in which slow, progressive muscle weakness with calcinosis can be easily treated with corticosteroid s. The second type is known as Banker type, characterized by a vasculitis of the muscles and gastrointestinal tract, rapid onset of severe weakness, steroid unresponsiveness, and high death date. ref name Andrews Pathology Dermatomyositis is confirmed by proximal muscle weakness, an electromyography with a characteristic spike and wave pattern, and abnormal Creatine kinase CPK or aldolase levels. Conclusive diagnosis requires a muscle biopsy that shows perifascicular infiltration of inflammatory cells. ref name Lehman cite author Thomas J. A. Lehman title It s not just growing pains a guide to childhood muscle, bone, and joint pain url http books.google.com books?id YjAId2FyYXQC&pg PA222&dq Childhood dermatomyositis&ei xt YSoKUEIGEkgSSzqCVAQ publisher Oxford University Press US year 2004 isbn 0195157281 pages 222 225 ref Treatment The more common type of dermatomyositis, the unicyclic Brunsting type , responds well to corticosteroid s and typically disappears within six months of treatment. Muscular ... of dermatomyositis can also be treated with corticosteroids and methotrexate , but respond poorly. Muscle cells that die during the inflammatory phase of dermatomyositis are non renewable, which can lead to permanent weakness. ref name Lehman See also List of cutaneous conditions Juvenile dermatomyositis References Reflist DEFAULTSORT Childhood Dermatomyositis Category Connective tissue diseases ... more details
No footnotes date April 2009 Infobox disease Name Juvenile dermatomyositis Image Dermatomyositis4.jpg Caption Juvenile dermatomyositis ICD10 ICD10 M 33 0 m 30 ICD9 ICD9 710.3 Juvenile dermatomyositis JDM is an idiopathic inflammatory myopathy IMM of presumed autoimmune dysfunction resulting in muscle weakness among other complications. It manifests itself in children it is the pediatric counterpart of dermatomyositis . In JDM, the body s immune system attacks blood vessels throughout the body, causing inflammation called vasculitis . In the United States , the incidence rate of JDMS is approximately 2 3 cases per million children per year.The UK incidence is believed to be between 2 3 per million children per year, with some difference between ethnic groups. The sex ratio Female Male is approximately 2 1. Other Idiopathic inflammatory myopathies include juvenile polymyositis PM and juvenile inclusion body myositis IBM , which are extremely rare and are not as common in children as in adults. Cause The underlying cause of JDM is unknown. It most likely has a genetics genetic component, as other auto immune disease tend to run in the families of patients. The disease is usually triggered by a condition that causes immune system activity that does not stop as it should, but the trigger is almost certainly not the cause in most cases. Common triggers include immunization s, infection s, injuries, and sunburn . Symptoms The vasculitis caused by JDMS manifests itself predominantly in two ways One is a distinctive rash . The rash often affects the face , eyelid s, and hand s, and sometimes ... survey of the diagnostic criteria for juvenile dermatomyositis JDM journal Rheumatology Oxford ... cite journal author Feldman BM, Rider LG, Reed AM, Pachman LM title Juvenile dermatomyositis and other ... Website http www.juveniledermatomyositis.org.uk Juvenile Dermatomyositis Research Group Systemic connective tissue disorders DEFAULTSORT Juvenile Dermatomyositis Category Pediatrics Category Systemic ... more details
association is weaker than in the related condition Dermatomyositis . The latter is linked ... by lymphocytic inflammation mainly cytotoxic T lymphocytes . Polymyositis, like dermatomyositis, strikes females with greater frequency than males. The skin involvement of dermatomyositis is absent ... and Dermatomyositis Autoimmune Disorders of Connective Tissue Merck Manual Home Edition cite web url http www.merck.com mmhe sec05 ch068 ch068e.html title Polymyositis and Dermatomyositis Autoimmune ... as polymyositis and dermatomyositis that does not respond to treatment is likely IBM ... apparently involve different disease mechanisms than are seen in dermatomyositis . Laboratory ... more details
distinguish meiosis miosis mitosis myosotis Infobox disease Name Myositis Image Caption DiseasesDB 29473 ICD10 ICD10 M 60 m 60 ICD9 ICD9 729.1 ICDO OMIM 160750 MedlinePlus 001245 eMedicineSubj eMedicineTopic MeshID D009220 Myositis is a general term for inflammation of the muscle s. Many such conditions are considered likely to be caused by autoimmune conditions, rather than directly due to infection although autoimmune conditions can be activated or exacerbated by infections. It is also a documented side effect of the lipid lowering drugs statins and fibrates. Elevation of creatine kinase in blood is indicative of myositis. Types Types of myositis include myositis ossificans idiopathic Inflammatory myopathy inflammatory myopathies dermatomyositis juvenile dermatomyositis polymyositis inclusion body myositis pyomyositis See also myopathy muscle disease myalgia muscle pain Masticatory muscle myositis a disease in dogs External links http www.myositis.org The Myositis Association http www.nlm.nih.gov medlineplus myositis.html NIH http www.myositis.org about myositis faq general.cfm FAQ http www.arthritis.org conditions DiseaseCenter myositis.asp Arthritis.org http www.hopkinsmedicine.org myositis The Johns Hopkins Myositis Center Inflammation Systemic connective tissue disorders Myopathy Category Inflammations Category Disorders of muscles disease stub ar roa rup Myositis de Myositis fr Myosite it Miosite kk ja no Myositt pt Miosite ru sq Myositis sv Myosit ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 M 33 m 30 ICD9 ICD9 710.3 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D003882 Dermatopolymyositis is a term used to describe a family of myositis disorders. These include polymyositis and dermatomyositis . ref name pmid4093921 cite journal author Tymms KE, Webb J title Dermatopolymyositis and other connective tissue diseases a review of 105 cases journal J. Rheumatol. volume 12 issue 6 pages 1140 8 year 1985 month December pmid 4093921 doi url ref The term PM DM is sometimes used to describe polymyositis and dermatomyositis. ref name pmid9921402 cite journal author Chraibi S, Ibnabdeljalil H, Habbal R, Bennis A, Tahiri A, Chraibi N title Pericardial tamponade as the first manifestation of dermatopolymyositis journal Ann Med Interne Paris volume 149 issue 7 pages 464 6 year 1998 month November pmid 9921402 doi url ref References reflist disease stub Systemic connective tissue disorders Category Inflammations Category Systemic connective tissue disorders ... more details
JDM is an abbreviation or initialism that may refer to Java Data Mining Java Device Manager, Nortel Device Manager Japanese domestic market car models and parts unique to Japan Jeannie Dance Music JDM This term was coined, By The Magic Of John Sanchez Feb 2000 . Jesus Disciples Movement Joint Design Manufacturing Juvenile dermatomyositis Jornada Del Muerto Motorcycle Riders Association Judgment and Decision Making , a subfield of psychology People Jim Morrison James Douglas Morrison Jim Morrison , singer Jens Dyekjaer Madsen , inventor of the original PIC microcontroller Device programmers device programmer used for programming microcontrollers such as the PIC line from Microchip Technology Jeffrey Dean Morgan , actor Jonathon Miller , BL player disambig de JDM fr JDM it JDM zh JDM ... more details
wiktionary Heliotrope may refer to Natural science Heliotropium , a genus of flowering plants A plant that exhibits heliotropism , diurnal motion in response to the sun s movement Heliotrope mineral Media and entertainment Heliotrope song Heliotrope song , by At the Drive In Heliotrope artist , Danish record producer Heliotrope Studios , a video game developer Heliotrope , a song by Robyn Hitchcock on the album Moss Elixir Heliotrope , a story collection by Justina Robson Other uses Heliotrope color Heliotrope instrument , a surveying tool Heliotrope building , a rotating home built by Rolf Disch A distinctive rash associated with juvenile dermatomyositis Disambig de Heliotrop ko ja pl Heliotrop sv Heliotrop uk ... more details
File Unverricht.jpg thumb Heinrich Unverricht. Heinrich Unverricht September 18, 1853 April 22, 1912 was a German internist who was a native of Breslau . In 1877 he obtained his doctorate from the University of Breslau , where he was a student of Michael Anton Biermer 1827 1892 . Later he was a professor at Jena 1886 and Dorpat 1888 , where he resigned in 1892 for political reasons, and became director of the city hospital at Magdeburg Sudenburg. Heinrich Unverricht is most remembered for his research of epilepsy , especially his work with progressive myoclonus epilepsies PME . In 1891 he described a form of PME that was later come to be known by the eponymous label Unverricht Lundborg disease Unverricht Lundborg disease . Equally notable, however, following Ernst Leberecht Wagner Wagner 1863 and Rudolf Virchow Virchow s 1866 initial clinical descriptions, in 1891 ref name Unverricht Dermatomyositis cite journal last Unverricht first H title Dermatomyositis acuta journal Dtsch Med Wochenschr year 1891 volume 17 pages 41 44 ref he developed the concept of an intimate connection between rash and muscle weakness that defined a new disorder ...it seems to me that the skin appearance plays such an important role in the disease picture that the designation Polymyositis is not completely accurate. In our case, the partnership of the skin and muscle disease allows us to use the elocution Dermatomyositis ... translation ref Levine TD History of Dermatomyositis. Arch Neurol 60 780 782, 2003 ref Unverricht published over fifty medical works, including Studien ber die Lungenentz ndung , his prize winning doctorate thesis on pneumonia . References reflist cite book title The founders of child neurology author Stephen Ashwal year 1990 publisher Norman Publishing isbn 0930405269 url http books.google.com books?id eDvHZWRo9 0C&pg PT312&lpg PT312&dq 22heinrich unverricht 22 1853&source web&ots wlAhJVjmVk&sig BkT7SXFiqvX56wNJx3GGtGUtsiU PPT313,M1 http www.whonamedit.com doctor.cfm 2 ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 Y43.3 ICD9 ICD9 E933.1 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Hydroxyurea dermopathy is caused by chronic use of hydroxyurea for chronic myelogenous leukemia , thrombocytopenia, or psoriasis, and presents with skin lesion s characteristic of dermatomyositis . ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 135 See also Skin lesion List of cutaneous conditions References reflist Cutaneous condition stub External causes of morbidity and mortality Category Drug eruptions ... more details
Infobox Disease Name Inflammatory myopathy Image Dermatomyositis intermed mag.jpg Caption Micrograph of dermatomyositis , a type of inflammatory myopathy. Muscle biopsy . H&E stain . DiseasesDB 29473 ICD10 ICD10 M 33 m 30 , ICD10 G 72 4 g 70 ICD9 ICD9 359.6 , ICD9 710.3 ICD9 710.4 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D009220 Inflammatory myopathy is a form of myopathy that involves inflammation of the muscle. Inflammatory myopathy is generally synonymous to the term dermatopolymyositis , which, according to ICD 10 encompasses three related diseases polymyositis , dermatomyositis , and inclusion body myositis . ref http apps.who.int classifications apps icd icd10online ?gm30.htm m33 ICD 10 M33 Dermatopolymyositis ref ref name BarnesHilton Jones2003 cite book author1 Phillip R. J. Barnes author2 David Hilton Jones title Myopathies in Clinical Practice url http books.google.com ?id 4Qs2e4rPM4kC&pg PA85 accessdate 26 June 2010 year 2003 publisher Informa Health Care isbn 9781899066711 pages 85 ref Diagnosis Inflammatory myopathy can be associated with increased Erythrocyte sedimentation rate ESR and creatine kinase . Dermatopolymyositis can be associated with several types of autoantibodies Anti Jo1 antibodies , ref name pmid9067664 cite journal author Kalenian M, Zweiman B title Inflammatory myopathy, bronchiolitis obliterans organizing pneumonia, and anti Jo 1 antibodies an interesting association journal Clinical and diagnostic laboratory immunology volume 4 issue 2 pages 236 40 year 1997 month March pmid 9067664 pmc 170510 doi url http cvi.asm.org cgi pmidlookup?view long&pmid 9067664 ref which is associated with a more abrupt onset of fever, cracked hands, Raynaud s phenomenon , interstitial lung disease , arthritis , and a poor response to therapy. ref name agabegi2nd254 Page 254 in cite book author Elizabeth D Agabegi Agabegi, Steven S. title Step ... Tovar MG, L pez Luna A, Avalos D az E, Herrera Esparza R title A dermatomyositis and scleroderma overlap ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICD9 275.4 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D002114 Calcinosis is the formation of calcium deposits in any soft tissue . Types Dystrophic calcification The most common type of calcinosis is dystrophic calcification . This type of calcification can occur as a response to any soft tissue damage, including that involved in implantation of medical devices. Metastatic calcification Metastatic calcification involves a systemic calcium excess imbalance, which can be caused by hypercalcemia , renal failure , milk alkali syndrome , lack or excess of other minerals, or other etiologies. Tumoral calcinosis The etiology of the rare condition of tumoral calcinosis is not entirely understood. It is generally characterized by large, globular calcifications near joints. See also calcinosis cutis dermatomyositis hypercalcemia hyperphosphatemia scleroderma Fahr s syndrome Primrose syndrome External links http www.rad.washington.edu mskbook softtissueca.html Univ. Washington School of Medicine article on Soft Tissue Calcifications Category Diseases and disorders Inborn errors of metal metabolism disease stub de Kalzinose es Calcificaci n nl Calcinosis pt Calcinose ru uk ... more details
Infobox disease Name Overlap syndrome Image Alt Caption DiseasesDB ICD10 ICD10 M 35 1 m 30 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID GeneReviewsID GeneReviewsName An overlap syndrome is an autoimmune disease of connective tissue ref DorlandsDict eight 000104573 overlap syndrome ref in which the patient presents with symptoms of two or more diseases. As much as 25 of all patients with connective tissue disease show signs of an overlap syndrome. Examples of overlap syndromes include MCTD and scleromyositis , but the exact diagnosis depends from which diseases the patient shows symptoms. In overlap syndromes, features of systemic lupus erythematosus SLE , systemic sclerosis , polymyositis , dermatomyositis , rheumatoid arthritis RA and Sj gren s syndrome are found often. ref cite journal title Overlap syndromes and mixed connective tissue disease author Maddison PJ. journal Curr Opin Rheumatol. year 1991 volume 3 pages 995 1000 pmid 1772755 doi 10.1097 00002281 199112000 00016 issue 6 ref References reflist Category Autoimmune diseases Category Rheumatology Category Syndromes disease stub Systemic connective tissue disorders pl Zesp nak adania ... more details
Although they vary in particulars, polymyositis , dermatomyositis and inclusion body myositis are idiopathic inflammatory myopathies IIM http www.ninds.nih.gov disorders inflammatory myopathies detail inflammatory myopathies.htm primarily characterized by chronic inflammation of human skeletal muscle tissue ref name Lundberg 2000 Lundberg I. and Y L Chung, 2000. Treatment and Investigations of idiopathic inflammatory myopathies. Rheumatology . 39 7 17. ref that ultimately causes the necrosis of muscle cells. This degeneration leads to muscle tissue wasting, weakness and fatigue among other serious effects. Until recently, exercise has been avoided as a type of therapy, and even forbidden due to the risk of triggering or amplifying inflammation. However, several studies have been conducted to test this assumption and have shown that Aerobics aerobic exercise as well as resistance training can maintain and even improve quality of life for IIM affected individuals without increased inflammatory response . ref name Painelli 2009 Painelli VdS, B Gualano, GG Artioli, AL de Sa Pinto, E Bonfa, AH Lancha Jr., FR Lima, 2009. The possible role of physical exercise on the treatment of idiopathic inflammatory myopathies. Autoimmunity Reviews . 8 355 359. ref Modes of Exercise Therapy Trials Isometric Activity In 1993, isometric exercise training was applied for four weeks resulting in isometric peak power at 60 of maximal voluntary contraction. ref name Hicks 1993 Hicks JE, F Miller, P Plotz, TH Chen and I Gerber, 1993. Isometric exercise increases strength and does not produce sustained creatinine phosphokinase increases in a patient with polymyositis. Journal of Rheumatology . 20 1399 ... and TD Beardmore, 1993. Resistive exercise in the rehabilitation of polymyositis dermatomyositis ..., 1998. Improvement of physical fitness and muscle strength in polymyositis dermatomyositis patients ... and dermatomyositis A pilot study. Rheumatology . 38, 608 611. ref where for 12 weeks, weight ... more details
report of CMV retinitis in a patient with dermatomyositis was recently published. ref cite journal author Kim HR, Kim SD, Kim SH, et al. title Cytomegalovirus retinitis in a patient with dermatomyositis ... more details
In medicine , malar rash from Latin lang la mala jaw, cheek bone , also called butterfly rash , is a medical sign consisting of a characteristic form of facial rash. It is often seen in Lupus erythematosus but is not pathognomonic it is also seen in other diseases such as Pellagra , dermatomyositis and Bloom Syndrome . The malar rash of lupus is red or purplish and mildly scaly. Characteristically, it has the shape of a butterfly and involves the bridge of the nose. Notably, the rash spares the naso labial folds of the face, which contributes to its characteristic appearance. It is usually macular with sharp edges and not itchy. The rash can be transient or progressive with involvement of other parts of the facial skin. A malar rash is present in approximately 46 65 of lupus sufferers and varies between different populations. ref name Houman2004 cite journal author Houman M, Smiti Khanfir M, Ben Ghorbell I, Miled M title Systemic lupus erythematosus in Tunisia demographic and clinical analysis of 100 patients journal Lupus volume 13 issue 3 pages 204 11 year 2004 pmid 15119551 doi 10.1191 0961203303lu530xx ref ref name Houman2004 ref cite journal author Vil L, Alarc n G, McGwin G, Friedman A, Baethge B, Bastian H, Fessler B, Reveille J title Early clinical manifestations, disease activity and damage of systemic lupus erythematosus among two distinct U.S. Hispanic subpopulations journal Rheumatology Oxford volume 43 issue 3 pages 358 63 year 2004 pmid 14623949 doi 10.1093 rheumatology keh048 ref There are numerous other conditions which can cause rashes with a similar appearance. Where lupus is suspected further medical test s usually an anti nuclear antibody ANA as a screening test which is not specific for systemic lupus erythematosus and a detailed history and examination are necessary to differentiate it from other conditions. Trivia Pop singer Seal musician Seal has a malar rash on his face due to discoid lupus . References references External links http librar ... more details
Scleromyositis or the PM Scl overlap syndrome is a complex autoimmune disease a disease in which the immune system attacks the body . Patients with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis , and is therefore considered an overlap syndrome . Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD and synthetase syndrome . Autoantibodies often found in these patients are the anti PM Scl anti Exosome complex exosome antibodies. ref cite journal author Jablonska S. and Blaszczyk M. journal Adv Exp Med Biol year 1999 title Scleroderma overlap syndromes volume 455 pages 85 92 pmid 10599327 ref The symptoms that are seen most often are typical symptoms of the individual autoimmune diseases and include Raynaud s phenomenon , arthritis , myositis and scleroderma . ref cite journal author Mahler, M. and Raijmakers R. title Novel aspects of autoantibodies to the PM Scl complex Clinical, genetic and diagnostic insights journal Autoimmunity Reviews year 2007 volume 6 pages 432 7 pmid 17643929 doi 10.1016 j.autrev.2007.01.013 issue 7 ref Treatment of these patients is therefore strongly dependent on the exact symptoms with which a patient reports to a physician and is similar to treatment for the individual autoimmune disease, often involving either immunosuppressive drug immunosuppressive or immunomodulating drugs. ref cite journal author Jablonska S. and Blaszczyk M. title Scleromyositis a scleroderma polymyositis overlap syndrome journal Clinical Rheumatology year 1998 volume 17 pages 465 7 pmid 9890673 doi 10.1007 BF01451281 issue 6 ref References references Category Autoimmune diseases Category Rheumatology disease stub ca Escleromiositis ... more details
The NURD complex, in Molecular Biology molecular biology , is a complex with both ATP dependent chromatin remodelling and histone deacetylase activities. ref name pmid9885572 cite journal author Xue Y, Wong J, Moreno GT, Young MK, C t J, Wang W title NURD, a novel complex with both ATP dependent chromatin remodeling and histone deacetylase activities. journal Mol Cell year 1998 volume 2 issue 6 pages 851 61 pmid 9885572 doi 10.1016 S1097 2765 00 80299 3 pmc ref The nucleosome remodelling and histone deacetylase NuRD complex contains seven subunits the histone deacetylase core proteins HDAC1 and HDAC2, the histone binding proteins RbAp46 and RbAp48, the metastasis associated proteins MTA1 and MTA2, the methyl CpG binding domain protein MBD3 and the chromodomain helicase DNA binding protein Mi2 or CHD2 . The histone deacetylases HDAC1 and Histone deacetylase 2 HDAC2 and the histone binding proteins RbAp48 and RbAp46 form a core complex shared between NuRD and Sin3 histone deacetylase complexes. ref name pmid10444591 cite journal author Zhang Y, Ng HH, Erdjument Bromage H, Tempst P, Bird A, Reinberg D title Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. journal Genes Dev year 1999 volume 13 issue 15 pages 1924 35 pmid 10444591 doi 10.1101 gad.13.15.1924 pmc 316920 ref See also ref name gary cite journal author Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D. title The dermatomyositis specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. journal Cell year 1998 volume 95 issue 5 pages 279 89 doi 10.1016 S0092 8674 00 81758 4 ref References reflist Category Protein domains ... more details
Drugbox Verifiedfields changed verifiedrevid 464390046 type mab image alt mab type mab source u target Interferon alfa Interferon &alpha tradename Drugs.com MedlinePlus pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA OTC, Rx only, Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD Benz POM, CD Anab POM or CD Inv POM legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration bioavailability protein bound metabolism elimination half life excretion CAS number Ref cascite changed ?? CAS number 1143503 67 6 ATC prefix none ATC suffix UNII Ref fdacite correct FDA UNII XOY1YA7RMC ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA PubChem DrugBank Ref drugbankcite correct drugbank DrugBank C 6518 H 10008 N 1724 O 2032 S 38 molecular weight 146.25 kDa Sifalimumab is a human monoclonal antibody designed for the treatment of SLE , dermatomyositis , and polymyositis . ref cite web title Statement On A Nonproprietary Name Adopted By The USAN Council Sifalimumab publisher American Medical Association url http www.ama assn.org ama1 pub upload mm 365 sifalimumab.pdf ref Sifalimumab was developed by MedImmune . References references monoclonals for immune system Category Monoclonal antibodies monoclonal antibody stub antineoplastic drug stub ... more details
Prose date April 2011 Infobox Disease Name Myalgia Image Myalgia of the biceps brachii.jpg Caption Myalgia of the right biceps brachii . DiseasesDB 22895 ICD10 ICD10 M 79 1 m 70 ICD9 ICD9 729.1 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Myalgia , or muscle pain , is a symptom of many diseases and disorders. The most common causes are the overuse or over stretching of a muscle or group of muscles. Myalgia without a traumatic history is often due to virus viral infection s. Longer term myalgias may be indicative of a metabolic myopathy , some nutritional deficiencies or chronic fatigue syndrome . Causes The most common causes of myalgia are overuse, injury or Strain injury strain . However, myalgia can also be caused by diseases, disorders, medications, or as a response to a vaccination . It is also a sign of acute rejection after heart transplant surgery. The most common causes are Injury or trauma, including sprains, hematoma Overuse using a muscle too much, too often, including protecting a separate injury Chronic tension Muscle pain occurs with Rhabdomyolysis , associated with Viral Compression injury Drug related, esp fibrates and statins , occ ACE inhibitors , cocaine , some retro viral drugs Severe potassium deficiency Fibromyalgia Infections, including Influenza the flu Lyme disease Malaria Toxoplasmosis Dengue Fever Hemorrhagic fever Muscle abscess Polio Rocky Mountain spotted fever Trichinosis roundworm Auto immune disorders, including Systemic lupus erythematosus Polymyalgia rheumatica Polymyositis Dermatomyositis Multiple Sclerosis this is neurologic pain localised to myotome Overuse Overuse of a muscle is using it too much, too soon and or too often. ref name MedlinePlus http www.nlm.nih.gov medlineplus ency article 003178.htm MedlinePlus ref Examples are Repetitive strain injury . Injury The most common causes of myalgia by injury are sprains and strain injury . ref name MedlinePlus Autoimmune Multiple sclerosis neurologic pain interpreted ... more details
unreferenced date October 2009 Infobox person name Tim Rooney image imagesize 250px caption birth name Timothy Hayes Yule birth date January 4, 1947 birth place Birmingham, Alabama death date death date and age 2006 09 23 1947 01 04 mf y death place Hemet, California yearsactive 1955 1983 spouse Timothy Hayes Yule January 4, 1947 September 23, 2006 , better known as Tim Rooney , was an American actor and voice actor . He was the second son of actor Mickey Rooney and suffered from a muscle disease known as dermatomyositis . He was born in Birmingham, Alabama . His mother was a former Miss Alabama and singer, B. J. Baker Betty Jane Rase , who performed as B. J. Baker. His notable appearances included the films Village of the Giants and Riot on Sunset Strip , and also the Television program TV series The Donald O Connor Show , Maverick TV series Maverick , Dr. Kildare , Gidget , Bewitched , Dragnet series Dragnet and the cartoon show Mister T TV series Mister T , in voiceovers. In 1962 he co starred as one of the children in the ABC comedy Room for One More TV series . In 1964 1965, he co starred with his father in Mickey TV series Mickey , an American Broadcasting Company ABC situation comedy about a family which operates a hotel in Newport Beach, California Newport Beach , California . He played Timmy Grady. Mickey Rooney appeared as Mickey Grady. Emmaline Henry starred as mother and wife, Nora Grady. Rooney died at the age of fifty nine on his father s 86th birthday . External links IMDb name 740362 Tim Rooney Persondata Metadata see Wikipedia Persondata . NAME Rooney, Tim ALTERNATIVE NAMES SHORT DESCRIPTION American actor DATE OF BIRTH January 4, 1947 PLACE OF BIRTH Birmingham, Alabama DATE OF DEATH September 23, 2006 PLACE OF DEATH Hemet, California DEFAULTSORT Rooney, Tim Category 1947 births Category 2006 deaths Category American voice actors Category American film actors Category American actors Category People from Hemet, California Category People with poliom ... more details
Other uses Heliotrope disambiguation File Heliotropium peruvianum.jpg thumb 240px left Heliotrope flowers Infobox Color title Heliotrope hex DF73FF r 223 g 115 b 255 c 13 m 55 y 0 k 0 h 286 s 55 v 100 source Maerz and Paul ref The color displayed in the color box above matches the color called heliotrope in the 1930 book by Maerz and Paul A Dictionary of Color New York 1930 McGraw Hill the color heliotrope is displayed on page 131, Plate 54, Color Sample C10. ref Heliotrope is a pink purple tint that is a representation of the color of the Heliotropium heliotrope flower . The first recorded use of Heliotrope as a color name in English language English was in 1882 . ref Maerz and Paul A Dictionary of Color New York 1930 McGraw Hill Page 196 Color Sample of Heliotrope Page 131 Plate 54 Color Sample C10 ref Heliotrope in culture In James Joyce s Finnegans Wake , heliotrope is the answer to the Maggies riddle in the game of Colours or Angels and Devils played by the children in Part II, Chapter 1. Throughout the chapter, the word heliotrope is disguised a number of times, hidden either in anagrams, riddles, puns, or obscure allusions. In P. G. Wodehouse s Thank You Jeeves Pauline Stoker escapes from her father s yacht and ends up in Bertie Wooster s heliotrope pajamas In Sarah Mlynowski s Parties & Potions , the Samsortas wear a gown that is heliotrope in color, as the color has magical properties that enhance natural beauty . The periorbital purplish discoloration occurring in dermatomyositis is called the Heliotrope rash after the color. Heliotrope is among the handful of half mourning colors worn by Victorian fashion Victorian s during the last stage of mourning . ref http www.fashion era.com mourning fashion.htm Mourning Fashion ref State University of New York at Purchase formerly had heliotrope as one of the college s colors. The University of Arkansas used heliotrope as one of the school colors in the early 1900s. Heliotrope was a popular color reference of Galto ... more details
For the German physician of the same name who lived from 1864 1938 Albert Fraenkel Albert Fraenkel 10 March 1848, Frankfurt Oder 6 July 1916, Berlin was a Germany German physician . He received his education at the gymnasium school of his native town and at the University of Berlin , whence he graduated as doctor of medicine in 1870. After having been assistant to Kussmaul, Ludwig Traube physician Ludwig Traube and Von Leyden in Berlin , he settled in the German capital, becoming lecturer at the university in 1877. He was a nephew of Traube, the third volume of whose Gesammelte Beitr ge zur Pathologic und Physiologic he published in 1878. Fraenkel received the title of Professor in 1884, and became director of the medical department of the Am Urbanplatz Hospital, Berlin. Literary works Following in the footsteps of Traube, Fraenkel s first works were on experimental pathology , among them being the following Ueber den Einfluss der Verminderten Sauerstoffzufuhr zu den Geweben auf den Eiweiszerfall , in Virchow s Archiv, vol. lxvii with Von Leyden, Ueber die Gr sse der Kohlens ureausscheidung im Fieber , ib. vol. lxxvi with Julius Geppert J. Geppert , Ueber die Wirkungen der Verd nnten Luft auf den Organismus , Berlin, 1873 After becoming lecturer at the university his field of special research was the disease s of the lungs and the heart . Of his essays and works in this area may be mentioned Bakteriologische Mittheilungen ber die Actiologie der Pneumonie , in Zeitsch. f r Klinische Medizin , vols. x. and xi., in which essay he was the first to expound the theory of the micrococci of pneumonia Pathologie und Therapie der Krankheiten des Respirationsapparates , 1890 1902 Ueber Septikopy mische Erkrankungen, Speciell Akute Dermatomyositis , 1894 Ueber Akute Leuk mie , 1895 Zur Pathologischen Anatomie des Bronchialasthma , 1898. His writings have appeared in the Charit Annalen , Zeitschrift f r Klinische Medizin , Berliner Klinische Wochenschrift , and Deutsche Medizi ... more details
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