? at the Cincinnati Center for Eosinophilic Disorders blood immune system DEFAULTSORT EosinophilGranulocyte ...Infobox Anatomy Name PAGENAME Latin GraySubject GrayPage Image Eosinophil blood smear.JPG Caption Eosinophil ... the eosinophil, two platelet s at the top left corner. Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Code TerminologiaHistologica 2 00 04.1.02017 Eosinophil granulocytes ... with allergy and asthma . They are granulocyte s that develop during hematopoiesis in the bone ... the cellular cytoplasm , which contain many chemical mediators, such as histamines and protein s such as eosinophil ... of the eosinophil, and are toxin toxic to both parasite and host tissues. In normal individuals ... by ex vivo culture experiments. Eosinophil development, migration and activation Eosinophils develop ... interleukin 3 IL 3 , interleukin 5 IL 5 , and granulocyte macrophage colony stimulating factor ... 2 IL 5, GM CSF, and IL 3 are important for eosinophil activation as well as maturation. There is evidence to suggest that eosinophil granule protein expression is regulated by the non coding RNA EGOT ..., a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression journal Blood ... of eosinophil cationic protein is determined by a gene polymorphism and post translational modifications ... such as superoxide , peroxide , and hypobromite hypobromous acid, which is preferentially produced by eosinophil ... D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via ... C, Bozza P, Weller P title The cellular biology of eosinophil eicosanoid formation and function journal ... Expression of vascular endothelial growth factor by human eosinophils upregulation by granulocyte ... 13 IL 13 , and TNF alpha . ref name rothenberg cite journal author Rothenberg M, Hogan S title The eosinophil ... Eosinophil granule proteins Following activation by an immune stimulus, eosinophils degranulate to release ... S0065 2776 08 60351 X ref These include major basic protein MBP eosinophil cationic protein ECP ... more details
by their appearance under Wright s stain Neutrophil granulocyte s Eosinophilgranulocyte s Basophil granulocyte s Their names are derived from their staining biology staining characteristics for example, the most abundant granulocyte is the neutrophil granulocyte , which has neutrally staining ...Image pBEosinophil.jpg framed Eosinophilic granulocyte Granulocytes are a category of white blood cell s characterized by not only illogical but not necessarily true as stated the fact that all types have differently staining biology staining the presence of Granule cell biology granule s in their cytoplasm . ref eMedicineDictionary granulocyte ref They are also called polymorphonuclear leukocytes PMN or PML because of the varying shapes of the cell nucleus nucleus , which is usually lobed into three segments. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocyte s, ref eMedicineDictionary polymorphonuclear leukocyte ref the most abundant ... last8 Chakrabarti first8 S last9 Mcavoy first9 E issn 1078 8956 ref Eosinophils main Eosinophil Image pBEosinophil.jpg framed An eosinophil surrounded by erythrocytes Eosinophils also have lobed nuclei two to four lobes . The number of granules in an eosinophil can vary because they have a tendency ... eosinophil.cfm title Segmented Eosinophil accessdate 2009 04 10 last Hess first Charles E. publisher .... ref cite journal author Kariyawasam HH, Robinson DS title The eosinophil the cell and its weapons ... agents Defensin s and Eosinophil cationic protein Enzyme s Lysozyme dissolves cell walls of some ... deficiency of neutrophil granulocyte s . Granulocytes live only one to two days in circulation ... associated with such a procedure. There is usually a granulocyte chemotactic defect in individuals ... da Granulocyt de Granulozyt es Granulocito eo Granulocito fa fr Granulocyte id Granulosit ... ru sq Granulociti simple Granulocyte sk Granulocyt sr fi Jyv ssolu sv Granulocyt ... more details
Eosinophil peroxidase is a haloperoxidase enzyme that in humans is encoded by the EPX gene . ref name ... and characterization of a chromosomal gene for human eosinophil peroxidase journal J. Biol. Chem. volume ... eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family journal J ... sub O sub 2 sub formed by the eosinophil , and either chloride or bromide ions, eosinophil peroxidase ... bacteria . Eosinophil peroxidase is a haloperoxidase that preferentially uses bromide over chloride ... 26129 36 year 2005 pmid 15894800 doi 10.1074 jbc.M503027200 ref Eosinophil peroxidase is also partly responsible for tissue remodeling. Role in pathology The oxidizing compounds produced by eosinophil ... of eosinophil peroxidase journal Biochem. J. volume 358 issue Pt 1 pages 233 9 year 2001 month August pmid 11485572 pmc 1222052 doi 10.1042 0264 6021 3580233 url ref See also Eosinophil Major basic ... C, et al. title Hereditary eosinophil peroxidase deficiency immunochemical and spectroscopic studies ... journal author Ten RM, Pease LR, McKean DJ, et al. title Molecular cloning of the human eosinophil ... author Ulrich M, Petre A, Youhnovski N, et al. title Post translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase journal J. Biol. Chem. volume 283 issue 42 ... Dalen CJ, Winterbourn CC, Kettle AJ title Mechanism of nitrite oxidation by eosinophil peroxidase ... Q, Stemmler S, Epplen JT, Hoffjan S title Variation in genes encoding eosinophil granule proteins ... Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase journal ... Nakamura H, Miyagawa K, Ogino K, et al. title High contribution contrast between the genes of eosinophil ... in the eosinophil peroxidase gene with allergic rhinitis in the Czech population journal Int. Arch ... polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis journal Int. Arch ... K, Kanda N, Ueda T, et al. title The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase ... more details
cloning of the human eosinophil derived neurotoxin a member of the ribonuclease gene family journal ... A family, 2 liver, eosinophil derived neurotoxin url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6036 accessdate ref The protein encoded by this gene is found in eosinophilgranulocyte s. References reflist Further reading refbegin 2 PBB Further reading citations ... 10.1007 BF02790409 cite journal author Abu Ghazaleh RI, Dunnette SL, Loegering DA, et al. title Eosinophil ... Hamann KJ, Ten RM, Loegering DA, et al. title Structure and chromosome localization of the human eosinophil derived neurotoxin and eosinophil cationic protein genes evidence for intronless coding sequences ... DA, et al. title Sequence of human eosinophil derived neurotoxin cDNA identity of deduced amino acid ..., et al. title Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases ... al. title Biochemical and functional similarities between human eosinophil derived neurotoxin and eosinophil ... MN title X ray crystallographic structure of recombinant eosinophil derived neurotoxin at 1.83 A resolution ... DG, Kita H, et al. title Localization of eosinophil derived neurotoxin and eosinophil cationic protein ... 9620664 doi cite journal author Zhang J, Rosenberg HF title Sequence variation at two eosinophil associated ... RNASE2 protein, human MeshName Eosinophil Derived Neurotoxin gene 14 stub Nucleases Granule ... more details
in human bronchial epithelial BEAS 2B cells. ref name Chang 2010 Clinical significance Eosinophilgranulocyte ...PBB geneid 6037 Eosinophil Cationic Protein ECP also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. ref name pmid11404391 cite journal author Boix E, Carreras E, Nikolovski Z, Cuchillo CM, Nogu s MV title Identification and characterization of human eosinophil cationic ... 35 year 2001 month June pmid 11404391 doi url ref In humans, the eosinophil cationic protein is encoded ... HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ title Localization of the human eosinophil Charcot Leyden crystal protein lysophospholipase gene CLC to chromosome 19 and the human ribonuclease 2 eosinophil derived neurotoxin and ribonuclease 3 eosinophil cationic protein genes RNS2 and RNS3 to chromosome ... weights from 18 22 kDa. ref Lee BioSolutions, Inc. http www.leebio.com eosinophil cationic protein human P359.html ref Function Eosinophil cationic protein and the sequence related eosinophil ... , parasitic worm helmintho toxic, and RNA ribonucleo lytic activities. Eosinophil cationic protein is localized to the granule matrix of the eosinophil . ref name pmid2387583 cite journal author Hamann ... Structure and chromosome localization of the human eosinophil derived neurotoxin and eosinophil cationic ... human eosinophil cationic protein. Ribonuclease activity is not essential for cytotoxicity journal ... Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein journal ... author Motojima S, Frigas E, Loegering DA, Gleich GJ title Toxicity of eosinophil cationic proteins ... exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian ... T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil ... HY, Chang MD title A heparan sulfate facilitated and raft dependent macropinocytosis of eosinophil ... CM, Nogu s MV title The cytotoxicity of eosinophil cationic protein ribonuclease 3 on eukaryotic ... more details
distinguish granulocyte macrophage colony stimulating factor PBB geneid 1440 Granulocyte colony stimulating ... tissue biology tissues to stimulate the bone marrow to produce granulocyte s and stem cell ... 3 kinase PI3K protein kinase B Akt signal transduction pathway. Discovery Mouse granulocyte colony ... in 1983, ref name pmid2990035 cite journal author Metcalf D title The granulocyte macrophage colony ... and expression of cDNA for human granulocyte colony stimulating factor journal Nature volume 319 ... granulocyte colony stimulating factor effects on normal and leukemic myeloid cells journal Science ... differentiation into mature granulocyte s. G CSF is also a potent inducer of HSCs mobilization ... Thomas J, Liu F, Link DC title Mechanisms of mobilization of hematopoietic progenitors with granulocyte ... S, Suess S, Spoelgen R, Henriques A, Ehrenreich H, Sch bitz WR, Bach A, Schneider A title Granulocyte .... title Molecular cloning and expression of cDNA for human granulocyte colony stimulating factor journal ... EA, Eagleton MC, Prior JL, Piwnica Worms D, Trinkaus K, Apicelli A, Weilbaecher K title Granulocyte ... investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis ... DA title The synergy between stem cell factor SCF and granulocyte colony stimulating factor G CSF molecular ... Granulocyte macrophage colony stimulating factor GM CSF and granulocyte colony stimulating factor ... journal author Zink T, Ross A, Ambrosius D, et al. title Secondary structure of human granulocyte ... K, et al. title Structural characterization of natural and recombinant human granulocyte colony ... doi cite journal author Souza LM, Boone TC, Gabrilove J, et al. title Recombinant human granulocyte ... M, Asano S, et al. title The chromosomal gene structure and two mRNAs for human granulocyte ... of a cDNA for human granulocyte colony stimulating factor G CSF from a glioblastoma multiforme ... S, et al. title Characterization of recombinant human granulocyte colony stimulating factor produced ... more details
Distinguish granulocyte colony stimulating factor PBB geneid 1437 Infobox protein family Symbol GM CSF Name Granulocyte macrophage colony stimulating factor image PDB 1csg EBI.jpg width caption three dimensional structure of recombinant human granulocyte macrophage colony stimulating factor Pfam PF01109 Pfam clan CL0053 InterPro IPR000773 SMART PROSITE PDOC00584 MEROPS SCOP 2gmf TCDB OPM family OPM protein CAZy CDD Drugbox Verifiedfields changed verifiedrevid 476997210 IUPAC name Human granulocyte macrophage colony stimulating factor image GMCSF Crystal Structure.rsh.png Clinical data tradename Identifiers CAS number Ref cascite correct ?? CAS number 83869 56 1 ATC prefix L03 ATC suffix AA09 DrugBank Ref drugbankcite changed drugbank DrugBank DB00020 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA Chemical data C 639 H 1006 N 168 O 196 S 8 molecular weight 14434.5 g mol Granulocyte macrophage colony stimulating factor , often abbreviated to GM CSF , is a protein secreted by macrophage s, T cell s, mast cells , endothelial cell s, and fibroblast s. Functions GM CSF is a cytokine that functions as a white blood cell growth factor . GM CSF stimulates stem cell s to produce granulocyte s neutrophil s, eosinophil s, and basophil s and monocyte s. Monocytes exit the circulation and migrate into tissue, whereupon they mature into macrophage s and dendritic cell s. Thus, it is part of the immune system immune inflammation inflammatory biochemical cascade cascade , by which ... factor 2 granulocyte macrophage url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1437 accessdate ref Glycosylation Human granulocyte macrophage colony stimulating factor ... of Rheumatoid Arthritis, Germany year 2010 ref See also Granulocyte macrophage colony stimulating ... gentaur web site http www.leukine.com http www.leukine.com Official Leukine web site MeshName Granulocyte ... yes DEFAULTSORT Granulocyte Macrophage Colony Stimulating Factor Category Cytokines Category Hematology ... more details
PBB geneid 1441 The granulocyte colony stimulating factor receptor G CSF R also known as CD114 C luster ... Molecular cloning of cDNAs for the human granulocyte colony stimulating factor receptor from HL ... biochemistry receptor for the granulocyte colony stimulating factor G CSF . ref name entrez cite web title Entrez Gene CSF3R colony stimulating factor 3 receptor granulocyte url http www.ncbi.nlm.nih.gov ... .The granulocyte colony stimulating factor receptor is present on precursor cells in the bone marrow ... of Granulocyte colony stimulating factor GCSF should be avoided, at least in children and adolescents ... author Ehlers S, Herbst C, Zimmermann M, et al. title Granulocyte colony stimulating factor G CSF ... Granulocyte colony stimulating factor receptor has been shown to Protein protein interaction ..., Csar XF title Direct binding of Shc, Grb2, SHP 2 and p40 to the murine granulocyte colony stimulating ... is activated by granulocyte colony stimulating factor G CSF and docks to the activated G CSF receptor ... TA title Granulocyte colony stimulating factor receptors on CD34 cells in patients with myelodysplastic ... DJ, Anderson K, Cannizzaro LA, et al. title Molecular cloning of cDNAs for the human granulocyte colony ... R, Nagata S title Chromosomal gene organization of the human granulocyte colony stimulating ... granulocyte colony stimulating factor receptor. journal Proc. Natl. Acad. Sci. U.S.A. volume 87 issue ... Fukunaga R, Ishizaka Ikeda E, Pan CX, et al. title Functional domains of the granulocyte colony stimulating ... granulocyte colony stimulating factor receptor gene CSF3R to chromosome 1 at region p35 p34.3. journal ... journal author Larsen A, Davis T, Curtis BM, et al. title Expression cloning of a human granulocyte ... Identification and characterization of receptors for granulocyte colony stimulating factor on human ... SE, Oates AC, Harpur AG, et al. title Tyrosine kinase JAK1 is associated with the granulocyte colony ... of a nonsense mutation in the granulocyte colony stimulating factor receptor in severe congenital ... more details
PBB geneid 1438 The granulocyte macrophage colony stimulating factor receptor also known as CD116 C luster of D ifferentiation 116 , is a receptor biochemistry receptor for granulocyte macrophage colony ... of sup 125 sup I labeled granulocyte colony stimulating factor to normal murine hemopoietic cells ... ref It is associated with Surfactant metabolism dysfunction type 4. Structure The granulocyte ... 3 IL 3 and Interleukin 5 IL 5 . The subunit contains a binding site for granulocyte macrophage ... BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF title Molecular assembly of the ternary granulocyte ... author Doyle SE, Gasson JC title Characterization of the role of the human granulocyte macrophage colony ... en&lr &q intitle 3ACharacterization of the role of the human granulocyte macrophage colony stimulating ... of a second subunit of the receptor for human granulocyte macrophage colony stimulating factor GM CSF ... T last6 Miyajima first6 A cite journal author Crosier KE title A functional isoform of the human granulocyte ... cloning of a soluble human granulocyte macrophage colony stimulating factor receptor journal ... granulocyte macrophage colony stimulating factor journal EMBO J. volume 8 issue 12 pages 3667 ... granulocyte macrophage colony stimulating factor receptor journal J. Biol. Chem. volume 263 ... journal author Williams WV title Molecular cloning of a soluble form of the granulocyte macrophage ... David B. cite journal author Jubinsky PT title Expression and function of the human granulocyte macrophage ... subunit of the granulocyte macrophage colony stimulating factor receptor journal Biochim. Biophys ... granulocyte macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine ... cellular localization of granulocyte macrophage colony stimulating factor GM CSF and GM CSF alpha ... author Lia F, Rajotte D, Clark SC, Hoang T title A dominant negative granulocyte macrophage colony ... apoptosis by granulocyte macrophage colony stimulating factor journal J. Immunol. volume 157 issue ... more details
Unreferenced stub auto yes date December 2009 Infobox Disease Name Granulocytosis Image Caption DiseasesDB 8995 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID In medicine , granulocytosis is the presence in peripheral blood of an increased number of granulocyte s, a category of white blood cell s. Often, the word refers to an increased neutrophil granulocyte count, as neutrophils are the main granulocytes. Causes An increase in eosinophil granulocyte is known as eosinophilia . Granulocytosis can be a feature of a number of diseases Infection , especially bacterium bacteria l Malignancy , most notably leukemia it is the main feature of chronic myelogenous leukemia , CML Autoimmune disease Prognostic relations In cardiovascular disease , increased white blood cell counts have been shown to indicate a worse prognosis. See also Agranulocytosis Complete blood count Bandemia Monocyte and granulocyte disease Paraneoplastic syndromes Category Monocyte and granulocyte disorders Med sign stub it Granulocitosi pl Granulocytoza ... more details
Expert subject medicine date February 2009 Myelopoiesis is the regulated formation of myeloid myeloid cells , including eosinophilic eosinophilic granulocytes , basophilic basophilic granulocytes , neutrophilic neutrophilic granulocytes , and monocytes . In hematology , myelopoiesis is the production of blood cells in the bone marrow . The myeloid progenitor can differentiate in the bone marrow into granulocyte s, macrophage s mature monocyte s , mast cell s whose blood borne progenitor is not well defined , and dendritic cell s of the innate immune system. The granulocytes, also called polymorphonuclear leukocytes because of their oddly shaped nuclei, give rise to three short lived cell types including eosinophil s, basophil s, and neutrophil s. A granulocyte differentiates into a distinct cell type by a process called granulopoiesis . In this process it first transforms from a common myeloblast myeloid progenitor to a common promyelocyte. This promyelocyte gives rise to a unique myelocyte that for the first time can be classified as a eosinophil, basophil, or neutrophil progenitor based on the histological staining affinity eosinophilic, basophilic, or neutral granules . ref Junqueira, Carneiro. Basic Histology, Text and Atlas.McGraw Hill Companies. 2005. ISBN 978 0 07 144116 2 ref The unique myelocyte next differentiates into a metamyelocyte and then a band cell , with a C shaped nucleus, before becoming a mature eosinophil, basophil, or neutrophil. Macrophages come from monoblast progenitors that differentriate into promonocytes , which mature into monocytes . Monocytes eventually enter the tissues and become macrophages . References reflist External links MeshName Myelopoiesis Blood physiology Category Hematopoiesis Category Histology biology stub es Mielopoyesis ... more details
Granulopoiesis or granulocytopoiesis is hematopoiesis of granulocyte s. It occurs primarily within bone marrow and involves the following stages Pluripotential hemopoietic stem cell Myeloblast Promyelocyte Eosinophilic myelocyte Eosino neutrophilic myelocyte neutro basophilic myelocyte Metamyelocyte Band cell Stab cell Granulocytes Eosinophil Eosino neutrophil neutro basophil It can be stimulated by Candida albicans . ref name pmid15068692 cite journal author Basu S, Zhang HH, Quilici C, Dunn AR title Candida albicans can stimulate stromal cells resulting in enhanced granulopoiesis journal Stem Cells Dev. volume 13 issue 1 pages 39 50 year 2004 month February pmid 15068692 doi 10.1089 154732804773099245 ref References Reflist Blood physiology Category Hematopoiesis pl Granulopoeza sv Granulopoes ... more details
Unreferenced date July 2008 An acidophile or acidophil , or, as an adjectival form, acidophilic describes is a term used by histologist s to describe a particular staining pattern of cells and tissues when using haematoxylin and eosin stains. Specifically, the name refers to structures which love acid, and take it up readily. It describes the microscopic appearance of cell biology cell s and Biological tissue tissue s, as seen down the microscope , after a histological section has been stained with an acidic dye . The most common such dye is eosin , which stains acidophilic organisms red and is the source of the related term eosinophilic . See also Anterior pituitary acidophil Basophilic Oxyphil cell Eosinophil granulocyte Stains Please name category Category Histology Category Staining biology stub ar pt Acidof lico ... more details
Lobation is a characteristic of the cell nucleus of certain white blood cell s, it is when the nucleus is segmented into two or more connected bulbs. class wikitable Lobated Luekus Cell type colspan 2 Image Lobation Neutrophil Image pBNeutrophil.jpg 75px Image Neutrophil.png 75px multilobed , i.e. having more than two lobes Eosinophil Image Eosinophil.jpg 75px Image Eosinophil2.png 75px bi lobed , i.e. having two lobes Basophil granulocyte Basophil Image PBBasophil.jpg 75px Image Basophil.png 75px bi or tri lobed References reflist Category Organelles medicine stub ... more details
Specific granules are secretory Vesicle biology vesicles found exclusively in cells of the immune system called granulocyte s. They are also known as secondary granules . It is sometimes described as applying specifically to neutrophils, ref name urlDefinition specific granule from Online Medical Dictionary cite web url http cancerweb.ncl.ac.uk cgi bin omd?specific granule title Definition specific granule from Online Medical Dictionary format work accessdate ref , and sometimes the term is applied to other types of cells. ref name pmid7334549 cite journal author Okuda M, Takenaka T, Kawabori S, Ogami Y title Ultrastructural study of the specific granule of the human eosinophil journal J. Submicrosc. Cytol. volume 13 issue 3 pages 465 71 year 1981 month July pmid 7334549 doi url ref These granule s store a mixture of cytotoxic molecules, including many enzyme s and antimicrobial peptide s, that are released by a process called degranulation following activation of the granulocyte by an immune stimulus. Specific granules are also known as secondary granules . ref name GreerWintrobe2008 cite book author1 John P. Greer author2 Maxwell Myer Wintrobe title Wintrobe s clinical hematology url http books.google.com books?id 68enzUD7BVgC&pg PA173 accessdate 10 November 2010 date 1 December 2008 publisher Lippincott Williams & Wilkins isbn 9780781765077 pages 173 ref Contents Examples of cytotoxic molecule stored by specific granules in different granulocytes include Neutrophil alkaline phosphatase , lactoferrin , lysozyme , myeloperoxidase , NADPH oxidase Eosinophil cathepsin , major basic protein Basophil heparin , histamine not directly cytotoxic Clinical significance A specific granule deficiency can be associated with CEBPE . ref OMIM 245480 SPECIFIC GRANULE DEFICIENCY SGD ref References reflist External links http nic.sav.sk logos books scientific node16.html Neutrophil granules at sav.sk Granule contents DEFAULTSORT Specific Granule Category Organelles Category Immunol ... more details
Hypereosinophilia is a disease characterised by a marked increase in the eosinophil count in the bloodstream. The eosinophil count in human blood is normally 0.4 10 sup 9 sup L 0.1 0.6 and results from a balance between production of eosinophils and emigration through post capillary venules Yamaguchi et al. 1991 . Eosinophils are only a small minority of peripheral blood leucocytes and in normal subjects, most are found in the tissues of the lung and gastro intestinal tract Beeken et al. 1987 . Blood eosinophil counts are arbitrarily classified as mild between 0.6 to 1.5 10 sup 9 sup L moderate between 1.5 to 5 10 sup 9 sup L and severe when greater than 5 10 sup 9 sup L. An elevated blood eosinophil count may be associated with a number of reactive conditions and with clonal disorders of the bone marrow. However, when the blood eosinophil count is persistently greater than 1.5 10 sup 9 sup L, for a period of more than six months, damage to end organs such as the heart, lungs, skin, joints and nervous system can be demonstrated, and in the absence of any clonal or reactive cause, the term idiopathic hypereosinophilic syndrome HES is used. The three defining criteria of HES are therefore Eosinophil count persistently greater than 1.5 10 sup 9 sup L Damage to end organs No ascertainable cause for the eosinophilia and no evidence of clonality . There are three categories of blood eosinophilia Reactive non clonal eosinophilia infections, parasitic infestations, asthma and allergies, respiratory diseases, cytokine infusions , vasculitides, non haematological malignant diseases, drug reactions and connective tissue diseases, Hodgkin s and non Hodgkin s lymphomas are included here as the eosinophils have not been shown to be clonal. Clonal Disorders of the Bone Marrow associated with eosinophilia Acute and chronic eosinophilic leukaemia, chronic myeloid leukaemia , polycythaemia ... Hypereosinophilic Syndrome research in UK Category Monocyte and granulocyte disorders ... more details
Infobox Disease Name Eosinopenia Image Caption DiseasesDB ICD10 D72.8 ICD9 ICD9 288.0 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Eosinopenia is a form of agranulocytosis where the number of eosinophil granulocyte is lower than expected. Leukocytosis with eosinopenia can be a predictor of bacterial infection. ref name pmid12829215 cite journal author Gil H, Magy N, Mauny F, Dupond JL title Value of eosinopenia in inflammatory disorders an old marker revisited language French journal Rev Med Interne volume 24 issue 7 pages 431 5 year 2003 pmid 12829215 doi 10.1016 S0248 8663 03 00138 3 url http linkinghub.elsevier.com retrieve pii S0248866303001383 ref It can be induced by the use of steroid s. ref name titleMonocytopenia Eosinopenia cite web url http www.pathology.vcu.edu education hematology wbc non neoplastic ben ezra sld019.htm title Monocytopenia Eosinopenia accessdate 2008 02 17 format work archiveurl http web.archive.org web 20080116055418 http www.pathology.vcu.edu education hematology wbc non neoplastic ben ezra sld019.htm Bot retrieved archive archivedate 2008 01 16 ref Pathological causes include burns and acute infections. See also Eosinophilia References reflist External links cite journal author Krause JR, Boggs DR title Search for eosinopenia in hospitalized patients with normal blood leukocyte concentration journal Am. J. Hematol. volume 24 issue 1 pages 55 63 year 1987 pmid 3799595 doi 10.1002 ajh.2830240108 Monocyte and granulocyte disease Category Monocyte and granulocyte disorders medicine stub es Eosinopenia it Eosinopenia he nds Eosinopenie pl Eozynopenia pt Eosinopenia ... more details
Infobox Anatomy Name CFU GM Latin GraySubject GrayPage Image Drzewko rozwojowe kom rek macierzystych krwi.JPG Caption Lineage. Captions in Polish, but GMP visible near bottom center. Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Code TerminologiaHistologica 2 00 04.3.02009 CFU GM or GMP , for granulocyte macrophage progenitor is a Hematopoietic stem cell Colony forming units colony forming unit . It is derived from CFU GEMM . The GM stands for granulocyte , monocyte . ref name urlHem I WBC Morphology and Physiology cite web url http www.clt.astate.edu wwilliam hem i wbc morphology and physiology.htm title Hem I WBC Morphology and Physiology work accessdate 2008 12 30 Dead link date October 2010 bot H3llBot ref It is the precursor for monoblast s and myeloblast s. Production is stimulated by granulocyte macrophage colony stimulating factor GM CSF . Granulocytes There is some controversy over which granulocyte s derive from CFU GM. There is little disagreement that neutrophil s come from CFU GM. Some sources state that basophil s also derive from CFU GM, but that eosinophil s come from CFU Eos . ref name isbn0 07 144159 X cite book author Ganong, William F. McPhee, Stephen J. Lingappa, Vishwanath R. title Pathophysiology of Disease An Introduction to Clinical Medicine Lange publisher McGraw Hill Medical location year 2005 pages 107 isbn 0 07 144159 X oclc doi accessdate ref Other sources state that basophils do not derive from CFU GM, but from a distinct CFU, titled CFU Baso . ref name isbn0 8385 8285 0 cite book author Rudolph, Colin David title Rudolph s pediatrics publisher McGraw Hill, Medical Pub. Division location New York year 2003 pages 1563 isbn 0 8385 8285 0 oclc doi accessdate ref See also Hematopoietic stem cell Nomenclature of hematopoietic colonies and lineages References reflist External links MeshName CFU GM Blood Blood physiology Category Colony forming units Category Hematopoietic stem cells Category Blood cells Cell bi ... more details
name Simon Patients displaying eosinophilia overexpress a gene encoding an eosinophil hematopoietin ... eosinophil production is induced by compounds released by basophils and mast cells , including eosinophil ... is by complete blood count CBC . However, in some cases, a more accurate absolute eosinophil count ... However, in primary eosinophilia, or if the eosinophil count must be lowered, corticosteroids such as prednisone ... Monocyte and granulocyte disease Category Monocyte and granulocyte disorders bg cs Eosinofilie ... more details
PBB geneid 5553 Proteoglycan 2, bone marrow natural killer cell activator, eosinophil granule major basic ..., eosinophil granule major basic protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein ... in allergic diseases. ref name entrez PRG2 is a 117 residue protein that predominates in eosinophil ... cells in vitro . The eosinophil major basic protein also causes the release of histamine from mast ... KR title Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm ... journal author Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR title Eosinophil ... plasma protein A and identification of the proform of eosinophil major basic protein as its physiological ... plasma protein A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate ... of eosinophil major basic protein journal J. Biol. Chem. volume 268 issue 17 pages 12243 6 publisher ... Eosinophil Major Basic Protein Further reading refbegin 2 PBB Further reading citations cite journal ... journal author Barker RL title Cloning and sequence analysis of the human gene encoding eosinophil ... TL title Evidence of eosinophil granule major basic protein in human placenta journal J. Exp. Med. volume ... in human eosinophil granule major basic protein cDNA journal J. Exp. Med. volume 168 issue 4 pages ... M title Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic ... sequence analysis of human eosinophil granule major basic protein journal J. Biol. Chem. volume 263 ... journal author Weller PF, Ackerman SJ, Smith JA title Eosinophil granule cationic proteins major basic protein is distinct from the smaller subunit of eosinophil peroxidase journal J. Leukoc. Biol ... of pregnancy associated plasma protein A messenger ribonucleic acid and eosinophil granule ... Gleich first7 GJ cite journal author Li MS title Human eosinophil major basic protein, a mediator of allergic ... more details
Infobox disease Name Hypereosinophilic syndrome Image Eosinophil.jpg Caption An eosinophil , the white blood cell involved in hypereosinophilic syndrome, seen amongst red blood cells . DiseasesDB ICD10 ICD10 D 72 1 d 70 ILDS D72.12 ICD9 ICD9 288.3 ICDO 9964 3 OMIM 607685 MedlinePlus eMedicineSubj med eMedicineTopic 1076 eMedicine mult eMedicine2 derm 920 MeshID D017681 The hypereosinophilic syndrome HES is a disease characterized by a persistently Eosinophilia elevated eosinophil count 1500 eosinophils mm in the blood for at least six months without any recognizable cause, with involvement of either the heart , nervous system , or bone marrow . ref name pmid1090795 cite journal author Chusid MJ, Dale DC, West BC, Wolff SM title The hypereosinophilic syndrome analysis of fourteen cases with review of the literature journal Medicine Baltimore volume 54 issue 1 pages 1 27 year 1975 pmid 1090795 doi 10.1097 00005792 197501000 00001 ref HES is a diagnosis of exclusion, after clonal eosinophilia such as leukemia and reactive eosinophilia in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia , or cancer have been ruled out. ref name Fazel New England Journal of Medicine 360 2005 2009 ref There are some associations with chronic eosinophilic leukemia ref name oxford cite book last Longmore first Murray coauthors Ian Wilkinson, Tom Turmezei, Chee Kay ... hypereosinophilic syndrome, of which the most important is blood testing. In HES, the eosinophil count ... cgi content full 348 13 1201 ref Treatment Treatment primarily consists of reducing eosinophil ... , are good for reducing eosinophil levels and antineoplastics are useful for slowing eosinophil ... in reducing blood eosinophil count to acceptable levels it is hoped that in the future hypereosinophilic ... DermNet systemic hypereosinophilic Monocyte and granulocyte disease Myeloid malignancy Category Eosinophilic cutaneous conditions Category Myeloid neoplasia Category Monocyte and granulocyte disorders ... more details
Gleich s syndrome or episodic angioedema with eosinophilia is a rare disease in which the body swells up episodically angioedema , associated with raised antibodies of the IgM type and increased numbers of eosinophil granulocyte s, a type of white blood cell s, in the blood eosinophilia . It was first described in 1984. ref name pmid6727934 cite journal author Gleich GJ, Schroeter AL, Marcoux JP, Sachs MI, O Connell EJ, Kohler PF title Episodic angioedema associated with eosinophilia journal N. Engl. J. Med. volume 310 issue 25 pages 1621 6 year 1984 pmid 6727934 doi 10.1056 NEJM198406213102501 ref Its cause is unknown, but it is unrelated to capillary leak syndrome which may cause similar swelling episodes and eosinophilia myalgia syndrome which features eosinophilia but alternative symptoms . Moreover, it is not a form of hypereosinophilic syndrome as there is no evidence that it leads to organ damage. Some studies have shown that edema attacks are associated with degranulation release of enzymes and mediators from eosinophils , and others have demonstrated antibody antibodies against endothelium cells lining blood vessels in the condition. ref name pmid10930860 cite journal author Emonet S, Kaya G, Hauser C title Gleich s syndrome journal Ann Dermatol Venereol volume 127 issue 6 7 pages 616 8 year 2000 pmid 10930860 url http www.masson.fr masson portal bookmark?Global 1&Path REVUE ADE 2000 127 6 7 ARTICLE11105965522.xml doi ref Gleich syndrome has a good prognosis. Attack severity may improve with glucocorticoid steroid treatment. ref name pmid6727934 ref name pmid10930860 References references Category Urticaria and angioedema Category Immune system disorders Cutaneous condition stub Immunology stub ja Angioedema with eosinophilia ... more details
Infobox Anatomy Name PAGENAME Latin GraySubject GrayPage Image Caption Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Code TerminologiaHistologica 2 00 04.3.02008 CFU GEMM is a Hematopoietic stem cell Colony forming units colony forming unit that generates myeloid cells. CFU GEMM cells are multipotential progenitor cell s. ref name pmid7679010 cite journal author Carow CE, Hangoc G, Broxmeyer HE title Human multipotential progenitor cells CFU GEMM have extensive replating capacity for secondary CFU GEMM an effect enhanced by cord blood plasma journal Blood volume 81 issue 4 pages 942 9 year 1993 month February pmid 7679010 doi url http www.bloodjournal.org cgi pmidlookup?view long&pmid 7679010 ref ref name pmid3332164 cite journal author Roodman GD, LeMaistre CF, Clark GM, Page CP, Newcomb TF, Knight WA title CFU GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high dose melphalan chemotherapy journal Bone Marrow Transplant. volume 2 issue 2 pages 165 73 year 1987 month August pmid 3332164 doi url ref The GEMM stands for granulocyte , erythrocyte , monocyte , megakaryocyte . ref name urlHem I WBC Morphology and Physiology cite web url http www.clt.astate.edu wwilliam hem i wbc morphology and physiology.htm title Hem I WBC Morphology and Physiology work accessdate 2008 12 30 Dead link date October 2010 bot H3llBot ref CFU GEMM gives rise to CFU GM . It has been suggested that eosinophil s do not derive from the common myeloid progenitor. ref name pmid19114669 cite journal author Mori Y, Iwasaki H, Kohno K, et al. title Identification of the human eosinophil lineage committed progenitor revision of phenotypic definition of the human common myeloid progenitor journal J. Exp. Med. volume 206 issue 1 pages 183 93 year 2009 month January pmid 19114669 doi 10.1084 jem.20081756 url http www.jem.org cgi pmidlookup?view long&pmid 19114669 pmc 2626675 ref References reflist 2 Blood ... more details
a deficiency of neutrophil s the most common granulocyte cell only. To be precise, neutropenia is the term ... terms can be used to specify the type of granulocyte referenced Inadequate numbers of neutrophil s neutropenia most common Inadequate numbers of eosinophil s eosinopenia uncommon Inadequate .... See also Complete blood count Granulocytosis References reflist Monocyte and granulocyte disease Category Monocyte and granulocyte disorders ar de Agranulozytose fr Agranulocytose ... more details
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