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Epidermal growth factor receptor
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Encyclopedia results for Epidermal growth factor receptor

Epidermal growth factor receptor





Encyclopedia results for Epidermal growth factor receptor

  1. Epidermal growth factor receptor

    geneid 1956 The epidermal growth factor receptor EGFR ErbB 1 HER1 in humans is the Cell membrane cell surface receptor biochemistry receptor for members of the epidermal growth factor family EGF family ... Herbst RS title Review of epidermal growth factor receptor biology journal Int. J. Radiat. Oncol. Biol ... url ref The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily ... or Medicine in 1986. Function EGFR epidermal growth factor receptor exists on the cell surface ... Rapid, Reversible Aggregation of the Purified Epidermal Growth Factor Receptor journal Biochemistry ... MD title Autophosphorylation sites on the epidermal growth factor receptor journal Nature volume 311 ... map of epidermal growth factor receptor signaling journal Mol. Syst. Biol. volume 1 issue 1 pages ... skin mediated by transactivation of the epidermal growth factor receptor journal J Clin Invest. volume ... the phosphorylation of the epidermal growth factor receptor in human colon carcinoma cells. ref name ... D title Oak ellagitannins suppress the phosphorylation of the epidermal growth factor receptor ... month May pmid 18419129 doi 10.1021 jf073427z ref Interactions Epidermal growth factor receptor ... GTPase mediates epidermal growth factor receptor dependent phospholipase D2 activation journal ... R B authorlink coauthors Norton L year 1998 month Apr. title The epidermal growth factor receptor modulates ... month Mar. title cbl b inhibits epidermal growth factor receptor signaling journal Oncogene volume ... I year 2002 month May. title Identification of epidermal growth factor receptor as a target of Cdc25A ... of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor journal J. Biol ... V year 2002 month Sep. title Decorin binds to a narrow region of the epidermal growth factor EGF receptor ... M M, Gendler S J year 2001 month Apr. title Transgenic MUC1 interacts with epidermal growth factor receptor ... and motility in MDA MB 231 human breast cancer cells downstream of epidermal growth factor receptor ...   more details



  1. Epidermal growth factor

    of epidermal growth factor receptor biology journal International Journal of Radiation Oncology, Biology ... by binding with high Affinity pharmacology affinity to epidermal growth factor receptor EGFR on the plasma .... Monoclonal antibodies are potential substances for this purpose. Interactions Epidermal growth factor has been shown to Protein protein interaction interact with Epidermal growth factor receptor ... for the COOH terminal region of the epidermal growth factor EGF receptor in amphiregulin and EGF mitogenic ...PBB geneid 1950 Epidermal growth factor or EGF is a growth factor that stimulates cell growth , cell growth proliferation , and Cellular differentiation differentiation by binding to its receptor Epidermal growth factor receptor EGFR . Human EGF is a 6045 dalton unit Da protein with 53 amino acid amino ... Carpenter G, Cohen S title Epidermal growth factor journal The Journal of Biological Chemistry volume ... 2 doi 10.1177 026010600902000204 ref Biological Sources Epidermal growth factor can be found in human ... KB, Loughlin SE, Morrison RS, Bradshaw RA, Knaver DJ, Cunningham DD title Epidermal growth factor ..., Ferns GA title The epidermal growth factor receptors and their family of ligands their putative role ... Role of the N terminus of epidermal growth factor in ErbB 2 ErbB 3 binding studied by phage display ... of Epidermal Growth Factor EGF at the http www.hprd.org protein 00578 Human Protein Reference Database . MeshName Epidermal growth factor http www.ebi.ac.uk biomodels main static pages.do?page ModelMonth ... growth factor journal Cell Biol. Int. volume 19 issue 5 pages 413 30 year 1995 pmid 7640657 doi 10.1006 cbir.1995.1086 cite journal author Dvorak B title Epidermal growth factor and necrotizing ... doi 10.1016 j.clp.2004.03.015 cite journal author Howell WM title Epidermal growth factor gene ... 16076471 doi 10.1016 j.atherosclerosis.2005.06.038 url ref Heparin binding EGF like growth factor HB EGF TGF alpha transforming growth factor TGF Amphiregulin AR Epiregulin EPR Epigen Betacellulin ...   more details



  1. Growth factor receptor

    A growth factor receptor is a Receptor biochemistry receptor which binds to growth factor . ref MeshName Growth Factor Receptors ref These receptors may use the JAK STAT signaling pathway JAK STAT , MAP kinase , and Phosphoinositide 3 kinase PI3 kinase pathways. ref name HoffbrandMoss2006 cite book author1 A. V. Hoffbrand author2 P. A. H. Moss author3 J. E. Pettit title Essential haematology url http books.google.com books?id IFFL 1YNy oC&pg PA6 accessdate 28 November 2010 year 2006 publisher Wiley Blackwell isbn 9781405136495 pages 6 ref References reflist Growth factor receptors Category Receptors biochem stub ...   more details



  1. Fibroblast growth factor receptor

    The fibroblast growth factor receptors are, as their name implies, Receptor biochemistry receptors that bind to members of the fibroblast growth factor family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia . Structure The fibroblast growth factor receptors consist of a cellular ligand domain composed of three ... splicing alternate splicing of four fibroblast growth factor receptor FGFR genes results in the production ... B. et al. title N glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co receptor binding journal J. Biol. Chem. year 2006 volume 281 issue 37 pages 27178 27189 ..., et al. title Receptor Specificity of the Fibroblast Growth Factor Family journal JBC volume 271 issue ... Sleeman M, Fraser J. et al. title Identification of a new fibroblast growth factor receptor, FGFR5 journal ... to the tyrosine kinase superfamily FGFR1 to FGFR4 . Gene FGFR1 see also Fibroblast growth factor receptor 1 CD331 Gene FGFR2 see also Fibroblast growth factor receptor 2 CD332 Gene FGFR3 see also Fibroblast growth factor receptor 3 CD333 Gene FGFR4 see also Fibroblast growth factor receptor 4 CD334 ... www.sabiosciences.com pathway.php?sn FGF Signaling FGF signaling with refs Growth factor receptors Tyrosine kinases DEFAULTSORT Fibroblast Growth Factor Receptor Category Tyrosine kinase receptors ... with tyrosine kinase activity. These receptors bind fibroblast growth factor s, members of the largest family of growth factor ligands, comprising 22 members. ref name ornitz cite journal author Ornitz DM. and Itoh, N. title Fibroblast growth factors journal Genome Biol. year 2001 volume 2 issue 3 ... journal author Coutts JC, and Gallagher JT. title Receptors for fibroblast growth factors journal .... Immunoglobulin like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs. In many cases, the FGFs themselves can also activate more than one receptor ...   more details



  1. Nerve growth factor receptor

    Nerve growth factor receptors are a group of growth factor receptor s which specifically bind to neurotrophin s. There are two classes of receptors, p75 and the Trk family of Tyrosine kinase s receptors. p75 is a low affinity neurotrophin receptor , to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase x only applies to this receptor. ref MeshName Nerve Growth Factor Receptor p75 ref The Trk receptor Trk family include TrkA , TrkB , and TrkC , and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. NGF binds to TrkA, BDNF and NT 4 bind to TrkB and NT 3 binds to TrkC . In addition NT 3 also binds to and activates TrkA and TrkB but it does so less efficiently. Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis . TrkA, B, and C receptors TrkA is a receptor tyrosine kinase meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling . There are other related Trk receptors TrkB and TrkC , and there are other neurotrophic factors structurally related to NGF BDNF , NT 3 , and NT 4 TrkA mediates the effects of NGF TrkB binds and is activated by BDNF , NT 4 , and NT 3 TrkC binds and is activated only by NT 3 LNGFR receptor The other NGF receptor, the LNGFR , for Low affinity nerve growth factor receptor , commonly known as p75 , plays a less clear role. LNGFR binds and serves as a sink for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity since they have a higher microconcentration of the neurotrophin. However ... basalis of postmortem Alzheimer s brains. References reflist External links MeshName Nerve Growth Factor Receptors Growth factor receptors Category Receptors biochem stub ...   more details



  1. Fibroblast growth factor receptor 3

    Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder ...PBB geneid 2261 Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene . ref name pmid1847508 cite journal author Keegan K, Johnson DE, Williams LT, Hayman MJ title Isolation of an additional member of the fibroblast growth factor receptor family, FGFR 3 journal Proc Natl Acad Sci U S A volume 88 issue 4 pages 1095 9 year 1991 month Mar pmid 1847508 pmc 50963 doi 10.1073 pnas.88.4.1095 ref FGFR3 has also been designated as CD333 cluster of differentiation 333 . Structure and function The PBB Summary template is automatically maintained by Protein Box Bot. See ... by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence ... FGFR3 fibroblast growth factor receptor 3 achondroplasia, thanatophoric dwarfism url http www.ncbi.nlm.nih.gov ... 17085196 doi 10.1016 j.juro.2006.07.132 ref Interactions Fibroblast growth factor receptor 3 has been ... Fibroblast growth factor receptor References Reflist Further reading refbegin 2 PBB Further ... Horton WA, Lunstrum GP title Fibroblast growth factor receptor 3 mutations in achondroplasia and related ... growth factor receptor autoinhibition and ligand binding promiscuity. journal Pnas USA ... Expression and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem. volume ... M, Ornitz D M year 1999 month Dec. title Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity journal J. Biol ... NLM content Tyrosine kinases Growth factor receptors Clusters of differentiation The PBB Controls ... of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals ... acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations ... Hafner C, Hartmann A, Vogt T title FGFR3 mutations in epidermal nevi and seborrheic keratoses lessons ...   more details



  1. Insulin-like growth factor 1 receptor

    drugs or radiotherapy. In breast cancer, where Epidermal growth factor receptor EGFR inhibitors ..., insulin like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology ... like growth factor receptor interplay with the epidermal growth factor receptor. journal Growth ...PBB geneid 3480 The Insulin like Growth Factor 1 IGF 1 Receptor is a protein found on the surface of human ... like growth factor 2 receptor IGF 2R and their respective ligands IGF 1 and IGF 2 , along ... growth factor I receptor journal Endocr. Rev. volume 16 issue 2 pages 143 63 year 1995 month April ... Echeverr a C, Hofmann F, Krystal GW title The insulin like growth factor I receptor kinase inhibitor ..., Garan SA, Gouw AM, Voelker MA, Sternberg H, Timiras PS title Insulin like growth factor 1 receptor ... like growth factor 1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced ... figitumumab . Interactions Insulin like growth factor 1 receptor has been shown to Protein protein ... 3 protein interacts with the insulin like growth factor I receptor journal Biochem. Biophys. Res. Commun ... M year 1995 month Aug. title Localization of the insulin like growth factor I receptor binding sites ... SOCS 2 with the insulin like growth factor I receptor journal J. Biol. Chem. volume 273 issue 37 ... regulates ligand induced ubiquitination and stability of the insulin like growth factor I receptor ... for the direct interaction of the insulin like growth factor I receptor with IRS 1, Shc, and Grb10 ... of the insulin like growth factor I receptor journal Cancer Res. volume 56 issue 14 pages 3165 ... C terminal Src kinase associates with ligand stimulated insulin like growth factor I receptor journal ... M year 2001 month Aug. title Association of insulin like growth factor 1 receptor with EHD1 .... title Identification of c Cbl as a new ligase for insulin like growth factor I receptor with distinct ... interaction of SHC and the insulin receptor substrate 1 IRS 1 with the insulin like growth factor ...   more details



  1. Fibroblast growth factor receptor 4

    protein tyrosine kinases and the epidermal growth factor receptor journal J. Biol. Chem. volume 270 ...PBB geneid 2264 Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 ... growth factor receptor family, where amino acid sequence is highly conserved between members and throughout ... fibroblast growth factor receptor 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2264 accessdate ref Interactions Fibroblast growth factor receptor 4 has been shown ... domain of recombinant human fibroblast growth factor receptor 4 journal Int. J. Biochem ... al. title A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter ... J, Bellosta P, et al. title Fibroblast growth factor receptor 4 shows novel features in genomic ... FGFR 4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern journal ... kinases expressed in human lung fourth member of the fibroblast growth factor receptor family and an intracellular ... Signal transduction by fibroblast growth factor receptor 4 FGFR 4 . Comparison with FGFR 1 journal ... D, Reich R, Chedid M, et al. title Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor journal J. Biol ... P, Alitalo K title Association of a 85 kDa serine kinase with activated fibroblast growth factor receptor ... DM, Xu J, Colvin JS, et al. title Receptor specificity of the fibroblast growth factor family journal ... factor receptor 4 gene to chromosome region 5q33 qter journal Genes Chromosomes Cancer volume 4 issue ... molecules between keratinocyte growth factor and basic fibroblast growth factor define domains ... tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth ... for members 1 3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor ...   more details



  1. Insulin-like growth factor 2 receptor

    A, Francke U title Chromosomal mapping of the gene for the type II insulin like growth factor receptor ... is a multifunctional protein receptor biochemistry receptor that binds insulin like growth factor 2 ... Insulin like growth factor 2 receptor has been shown to Protein protein interaction interact with M6PRBP1 ... author Hawkes C, Kar S title The insulin like growth factor II mannose 6 phosphate receptor structure ... Insulin like growth factor II receptor as a multifunctional binding protein journal Nature volume 329 ... 6 phosphate insulin like growth factor II receptor locus in human hepatocellular tumors journal ... Siemsen C, Waheed A, et al. title Localization of the insulin like growth factor II binding site to amino acids 1508 1566 in repeat 11 of the mannose 6 phosphate insulin like growth factor II receptor ... 6 Phosphate Insulin like Growth Factor II Receptor Targets the Urokinase Receptor to Lysosomes ... Like Growth Factor II Receptor PDB Gallery geneid 3482 Clusters of differentiation Growth factor receptors ... O Dell SD, Day IN title Insulin like growth factor II IGF II journal Int. J. Biochem. Cell Biol ... M title Expression of insulin like growth factors I and II and their receptor mRNAs in primary ... cite journal author Zhou J, Bondy C title Insulin like growth factor II and its binding proteins ... growth factor binding proteins in the human adrenal gland journal Mol. Cell. Endocrinol. volume 97 ... Ishiwata T, Bergmann U, Kornmann M, et al. title Altered expression of insulin like growth factor II ... Identification and cloning of a connective tissue growth factor like cDNA from human osteoblasts encoding ...PBB geneid 3482 about the cation independent mannose 6 phosphate receptor the cation dependent receptor cation dependent mannose 6 phosphate receptor In the fields of biochemistry and cell biology , the insulin like growth factor 2 receptor IGF2R , also called the cation independent mannose 6 phosphate receptor CI MPR is a protein that in humans is encoded by the IGF2R gene . ref name pmid2963003 cite ...   more details



  1. Platelet-derived growth factor receptor

    Refimprove date September 2010 protein Name PDGFRA platelet derived growth factor receptor, alpha polypeptide ... PDGFRB platelet derived growth factor receptor, beta polypeptide caption Ribbon image of two molecules of human PDGF receptor beta yellow and magenta in complex with dimeric PDGFB PDGF B cyan and green ... Platelet derived growth factor receptors PDGF R are cell surface receptor tyrosine kinase tyrosine kinase receptor s for members of the platelet derived growth factor PDGF family. PDGF subunits PDGFA ... growth , Morphogenesis development and many diseases including cancer . ref name pmid2538922 Cite journal author Williams LT title Signal transduction by the platelet derived growth factor receptor ... derived growth factor three isoforms and two receptor types journal Trends Genet. volume 5 issue ... derived growth factor isoform specific signalling via heterodimeric or homodimeric receptor complexes ... External links MeshName Platelet Derived Growth Factor Receptors Tyrosine kinases Growth factor receptors http angiogenesis.amgen.com DEFAULTSORT Platelet Derived Growth Factor Receptor Category Growth ... X. title Structures of a platelet derived growth factor propeptide complex and a platelet derived growth factor receptor complex journal PNAS volume 107 issue 25 no 25 pages 11307 12 year 2010 pmid 20534510 ... Depending on which growth factor is bound, PDGF R homo or heterodimerizes. ref name pmid1315403 Cite ... with signal transduction molecules Tyrosine phosphorylation sites in growth factor receptors serve ... in their monomer ic forms. The PDGFs bind to the protein Receptor tyrosine kinase tyrosine kinase receptor s PDGF receptor and . These two receptor isoform s protein dimer dimer ize upon binding the PDGF dimer, leading to three possible receptor combinations, namely , and . The extracellular region of the Receptor biochemistry receptor consists of five immunoglobulin like domains ... AA binds only to PDGFR , while PDGF BB is the only PDGF that can bind all three receptor combinations ...   more details



  1. Fibroblast growth factor receptor 2

    PBB geneid 2263 Fibroblast growth factor receptor 2 FGFR2 also known as CD332 cluster of differentiation ... A, Courtois Y, Breathnach R title Related fibroblast growth factor receptor genes exist in the human ... fibroblast growth factors journal EMBO J. volume 9 issue 9 pages 2685 92 year 1990 month September pmid 1697263 pmc 551973 doi url ref FGFR2 is a receptor for fibroblast growth factor . The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid ... Gene FGFR2 fibroblast growth factor receptor 2 bacteria expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson Weiss syndrome url ... alternatives of fibroblast growth factor receptor 2 FGFR2 journal Dev. Biol. volume 158 issue 2 pages ... are associated with craniosynostosis . Interactions Fibroblast growth factor receptor 2 has ... of fibroblast growth factor receptor ectodomain bound to ligand and heparin journal Nature volume ... bone and blood vessels. Like the other members of the Fibroblast growth factor receptor family ... growth factor receptor 3 kinase domain journal Mol. Cell. Biol. volume 17 issue 10 pages 5739 ... Heparan sulfate fibroblast growth factor receptor complex structure function relationships journal ... Fibroblast Growth Factor Receptor 2 PDB Gallery geneid 2263 Tyrosine kinases Clusters of differentiation ... growth factor, depending on the isoform. Isoforms FGFR2 has two naturally occurring isoforms ... factor receptor with its ligands journal Proc. Natl. Acad. Sci. U.S.A. volume 97 issue 1 pages 49 54 ... and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem. volume ... growth factor family journal J. Biol. Chem. volume 271 issue 25 pages 15292 7 year 1996 ... 3 , FGF7 7 , FGF10 10 , FGF22 22 FGFR2IIIc binds to FGF 1, basic fibroblast growth factor 2 , FGF4 4 .... The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion ...   more details



  1. Fibroblast growth factor receptor 1

    PBB geneid 2260 Fibroblast growth factor receptor 1 FGFR1 , also known as basic fibroblast growth factor receptor 1 , fms related tyrosine kinase 2 Pfeiffer syndrome , and cluster of differentiation CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor ... form of human basic fibroblast growth factor receptor deduced from its cDNA journal Biochem. Biophys ... growth factor receptor 1 fms related tyrosine kinase 2, Pfeiffer syndrome url http www.ncbi.nlm.nih.gov ... Fibroblast growth factor receptor 1 has been shown to Protein protein interaction interact with GRB14 ... growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor ... motif on fibroblast growth factor receptor mediates direct association and activation of SNT ... and function of vertebrate fibroblast growth factor receptor 1 journal Int. J. Dev. Biol. volume ... 291X 90 90384 Y url ref Function The protein encoded by this gene is a member of the fibroblast growth factor receptor FGFR family, where amino acid sequence is highly conserved between members and throughout ... Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors journal Mol. Cell. Biol. volume ... title Expression and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem ..., absent smell, selfish testes the pleiotropic consequences of human FGF receptor mutations journal Cytokine Growth Factor Rev. volume 16 issue 2 pages 187 203 year 2005 pmid 15863034 doi 10.1016 j.cytogfr.2005.03.001 ... factor receptor 1 on the Atlas of Genetics and Cytogenetics in Oncology and Haematology Atlas of Genetics ... tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factor s, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors ... author Johnson DE, Williams LT title Structural and functional diversity in the FGF receptor ...   more details



  1. Growth factor

    derived neurotrophic factor BDNF Epidermal growth factor EGF Erythropoietin EPO Fibroblast growth ... healing Overview of involved growth factors Signal transduction Receptor biochemistry Cytokine Angiogenesis Human Genome Organisation Growth factor receptor Mitogen References reflist External links ...A growth factor is a naturally occurring substance capable of stimulating cellular growth , ref DorlandsDict three 000038554 growth factor ref proliferation and cellular differentiation . Usually it is a protein or a steroid hormone . Growth factors are important for regulating a variety of cellular ... differentiation, while fibroblast growth factor s and vascular endothelial growth factor s stimulate blood vessel differentiation angiogenesis . Growth factors versus cytokines Growth factor is sometimes ... development and in the mature organism. While growth factor implies a positive effect on cell division ... growth factor proteins tend to occur as members of larger families of structurally and evolution arily ... CSF Granulocyte macrophage colony stimulating factor GM CSF Growth differentiation factor 9 GDF9 Hepatocyte growth factor HGF Hepatoma derived growth factor HDGF Insulin like growth factor IGF Migration stimulating factor Myostatin GDF 8 Nerve growth factor NGF and other neurotrophins Platelet derived growth factor PDGF Thrombopoietin TPO Transforming growth factor alpha TGF Transforming growth factor beta TGF Tumor necrosis factor alpha TNF Vascular endothelial growth factor VEGF Wnt Signaling Pathway placental growth factor PlGF Foetal Bovine Somatotrophin FBS IL 1 Cofactor for IL 3 and IL 6. Activates T cells. IL 2 T cell growth factor. Stimulates IL 1 synthesis. Activates B cells and NK cells. IL 3 Stimulates production of all non lymphoid cells. IL 4 Growth factor for activated .... IL 6 Stimulates Ig synthesis. Growth factor for plasma cells. IL 7 Growth factor for pre B ... Category Growth factors Category Immune system ar ca Factor de creixement cs R stov faktor ...   more details



  1. Growth factor-like domain

    Pfam box Symbol APP CU bd Name Amyloid precursor N terminal image 1mwp gfld.png width 200 caption The GFLD region of amyloid precursor protein Pfam PF02177 InterPro IPR008154 SMART SM00006 PROSITE SCOP 1mwp TCDB PDB PDB2 1mwp , PDB2 1owt , PDB2 2fjz , PDB2 2fk1 , PDB2 2fk2 , PDB2 2fk3 , PDB2 2fkl , PDB2 2fma A growth factor like domain GFLD is a protein domain structurally related to epidermal growth factor , which has a high binding affinity for the epidermal growth factor receptor . As structural domains within larger proteins, GFLD regions commonly bind calcium ion s. A subtype present in the N terminus N terminal region of the amyloid precursor protein is a member of the heparin binding class of GFLDs and may itself have growth factor function, particularly in promoting neuron al development. References Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999 . Crystal structure of the N terminal, growth factor like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6 4 327 31. protein stub Category Protein domains ...   more details



  1. Keratinocyte growth factor

    The Keratinocyte Growth Factor KGF , also known as FGF7 , is a growth factor present in the epithelialization phase of wound healing . In this phase, keratinocytes are covering the wound, forming the epithelium . KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b FGFR2b . ref name pmid18575591 cite journal author Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A title Silencing of Keratinocyte Growth Factor Receptor Restores 5 Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells journal PLoS ONE volume 3 issue 6 pages e2528 year 2008 pmid 18575591 pmc 2424182 doi 10.1371 journal.pone.0002528 url http www.plosone.org article info doi 10.1371 journal.pone.0002528 editor1 last Maas editor1 first Stefan ref For signalling to occur, a dimer is required between two FGF FGFR complexes that is linked together by a molecule of heparin. There are 23 known FGFs, and 4 FGF receptor s. FGF FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner. FGF10 is also known as Keratinocyte growth factor 2 . ref name urliHOP Information Hyperlinked over Proteins FGF10 cite web url http www.ihop net.org UniPub iHOP gs 88201.html title iHOP Information Hyperlinked over Proteins FGF10 format work accessdate ref See also Palifermin References reflist External links http www personal.umich.edu lpt fgf 1fq9 files side.jpg http www personal.umich.edu lpt fgf 1fq9.htm Category Growth factors medicine stub Growth factors it KGF fattore di crescita ...   more details



  1. Transforming growth factor

    Transforming growth factor sometimes referred to as Tumor growth factor , or TGF is used to describe two classes of polypeptide growth factor s, TGF&alpha and TGF beta TGF&beta . The name Transforming Growth Factor is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor biochemistry receptor mechanism biology mechanisms . Furthermore, they do not always induce cellular transformation , and are not the only growth factors that induce cellular transformation. Types TGF&alpha is upregulated in some human cancer s. It is produced in macrophage s, brain cells, and keratinocyte s, and induces epithelium epithelial development. TGF beta TGF exists in three known subtypes in humans, TGF&beta 1, TGF&beta 2, and TGF&beta 3. These are upregulated in Marfan s syndrome ref name dysregmarfan Circulating transforming growth factor beta in Marfan syndrome. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC GenTAC Consortium. Circulation. 2009 Aug 11 120 6 526 32. Epub 2009 Jul 27. PMID 19635970 ref ref name popmarfan http sciencenow.sciencemag.org cgi content full 2008 625 3?etoc Inhibiting TGF to help Marfan ref and some human cancers, and play crucial roles in tissue regeneration , cell differentiation ... growth factor beta TGF 1 are also thought to be involved in the pathogenesis of pre eclampsia . TGF&beta receptors are single pass serine threonine kinase receptor s. Function These proteins were originally ...?search TGF Tumor growth factor TGF citations http www.ihop net.org UniPub iHOP gs 125537.html ... MeshName Transforming Growth Factors Signaling proteins Category Growth factors Category Signal transduction cs Transformuj c r stov faktor de Transforming growth factor fr Facteur de croissance de ... in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors ...   more details



  1. Growth hormone secretagogue receptor

    PBB geneid 2693 Growth hormone secretagogue receptor is a G protein coupled receptor that binds ghrelin ... S title Loss of constitutive activity of the growth hormone secretagogue receptor in familial short ... name entrez cite web title Entrez Gene GHSR growth hormone secretagogue receptor url http www.ncbi.nlm.nih.gov .... title Growth hormone secretagogue receptor family members and ligands. journal Endocrine volume 14 ... Structure and regulation of the growth hormone secretagogue receptor. journal Minerva Endocrinol ... Cloning and characterization of the 5 flanking region of the human growth hormone secretagogue receptor ... growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity ... of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor ... studies of transgenic mice overexpressing growth hormone GH secretagogue receptor 1A in GH ... language archiveurl archivedate quote MeshName growth hormone secretagogue receptor http www.vivo.colostate.edu ..., Pin JP, Spedding M, Kojima M, Kangawa K title International Union of Pharmacology. LVI. Ghrelin receptor ... 17983854 doi 10.1016 S0083 6729 06 77005 4 ref Function Ghrelin is an appetite regulating factor secreted from peripheral organs that is involved in regulation of energy homoeostasis via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. ref cite journal author ... intake and growth hormone secretion journal Endocrinology volume 141 issue 11 pages 4325 8 year 2000 ...?view long&pmid 11089570 ref The pathway activated by binding of Ghrelin to the Growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen activated protein kinase ... One of the important features of GHSR1a displays Receptor biochemistry Binding and activation ... of receptor internalization as well as of signaling activity. ref name pazos2007 Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity. ref cite ...   more details



  1. Hepatocyte growth factor

    SA title Identification of the hepatocyte growth factor receptor as the c met proto oncogene product ... Identification of the hepatocyte growth factor receptor as the c met proto oncogene product journal ...PBB geneid 3082 Hepatocyte growth factor scatter factor HGF SF is a paracrine cellular growth, motility and morphogen morphogenic factor . It is secreted by mesenchymal cell s and targets and acts primarily ... growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto oncogenic c Met receptor ref name pmid1846706 ... science.1846706 url issn ref . Hepatocyte growth factor is secreted by mesenchymal cells and acts ... growth factor hepapoietin A scatter factor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... noedit ref ref name HahnPyun2011 cite pmid 21898720 noedit ref Interactions Hepatocyte growth factor ... month Oct. title Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET ... author Michalopoulos GK, Zarnegar R title Hepatocyte Growth Factor journal Hepatology volume 15 ... and function of hepatocyte growth factor journal Prog. Growth Factor Res. volume 3 issue 1 pages ... Hepatocyte growth factor from diagnosis to clinical applications journal Clin. Chim. Acta volume ... Skibinski G title The role of hepatocyte growth factor c met interactions in the immune system journal ... 10.1172 JCI20530 pmc 297008 cite journal author Hurle RA title Hepatocyte growth factor scatter factor ... 10.1042 BST0340414 refend PDB Gallery geneid 3082 See also growth factor hepatocyte growth factor receptor HGFR External links MeshName Hepatocyte growth factor http atlasgeneticsoncology.org Genes HGFID385ch7q21.html Hepatocyte growth factor on the Atlas of Genetics and Cytogenetics in Oncology and Haematology ... with growth factors and morphogens editor Iozzo, M, V. year 2000 publisher Marcel Dekker ... month title Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant ...   more details



  1. Insulin-like growth factor

    Image 3GF1 Insulin Like Growth Factor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein ... often referred to as the IGF axis consists of two cell surface receptor s IGF1R and IGF2R , two ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growth factor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growth factor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growth factor 1 IGF 1 is mainly secreted by the liver as a result of stimulation by growth hormone GH . IGF 1 is important for both the regulation ... death apoptosis . Insulin like growth factor 2 IGF 2 is thought to be a primary growth factor required for early development while IGF 1 expression is required for achieving maximal growth. Gene ... like Growth Factor I and Insulin like Growth Factor Binding Protein 3 with Intelligence Quotient ... tissue types express the IGF 1 receptor , IGF 1 s effects are diverse. It acts as a neurotrophic factor ... like growth factor binding protein IGF Binding Proteins . These proteins help to modulate IGF ... R, Goldfine ID, Pezzino V year 1993 title Insulin like growth factor I receptors are overexpressed ... hormone insulin like growth factor GH IGF axis by pharmaceutical, nutraceutical and environmental ... like growth factor 1 messenger RNA expression are severely attenuated in middle aged and aged rats ... 4522 97 00539 3 ref See also Insulin like growth factor 1 Insulin like growth factor 2 Growth hormone ... D last2 Dawes first2 PJ. year 2007 title Childhood hearing is associated with growth rates in infancy ... PDR.0b013e3181425869 ref IGF Receptors The IGF s are known to bind the IGF 1 receptor , the insulin receptor , the insulin like growth factor 2 receptor IGF 2 receptor , the insulin related receptor and possibly other receptors. The IGF 1 receptor is the physiologic receptor IGF 1 binds to it at significantly higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF 1 ...   more details



  1. Placental growth factor

    title Placental growth factor PlGF and its receptor Flt 1 VEGFR 1 novel therapeutic targets for angiogenic ... like domain of the vascular endothelial growth factor placenta growth factor receptor Flt 1 ...PBB geneid 5228 Placental growth factor is a protein that in humans is encoded by the PGF gene . ref name entrez cite web title Entrez Gene PGF placental growth factor, vascular endothelial growth factor ... mRNAs coding for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single ... doi url issn ref Placental growth factor PGF is a member of the VEGF vascular endothelial growth ... Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation journal ... growth factor dependent and independent regulation of angiogenesis journal BMB Rep volume ... for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single gene of chromosome ... JY cite journal author Park JE title Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt 1 but not to Flk 1 ... N cite journal author Hauser S, Weich HA title A heparin binding form of placenta growth factor PlGF ... Mattei MG title Assignment of vascular endothelial growth factor VEGF and placenta growth factor ... author Ziche M title Placenta growth factor 1 is chemotactic, mitogenic, and angiogenic journal Lab ... Vuorela P title Expression of vascular endothelial growth factor and placenta growth factor in human ... first8 E cite journal author Cao Y title Placenta growth factor identification and characterization ... Y, Claesson Welsh L title Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase ... growth factor VEGF forms VEGF 145 and VEGF 165 corrected journal J. Biol. Chem. volume 275 issue 24 ... structure of human placenta growth factor 1 PlGF 1 , an angiogenic protein, at 2.0 A resolution journal ... KR cite journal author Li XF title Angiogenic growth factor messenger ribonucleic acids in uterine ...   more details



  1. Nerve growth factor

    called growth factor receptor bound protein 2 Grb2 along with a docking protein called Grb2 associated ... growth factor receptor . ref name pmid11729324 ref name pmid14985763 See also Protein targeting Nervous ...PBB geneid 4803 Nerve growth factor NGF is a small secreted protein that is important for the growth ... ref It is perhaps the prototypical growth factor , in that it is one of the first to be described. While nerve growth factor refers to a single factor, ref MeshName Nerve Growth Factor ref nerve ... factor causes axonal growth. Studies have shown that it causes axonal branching and a bit of elongation ... factor receptor neurotrophin receptor p75 NTR and TrkA, a transmembrane tyrosine kinase. Both are associated ... of nerve growth factor dependent sympathetic neurons journal J. Neurosci. volume 18 ... tumor necrosis factor receptor members such as TRAF6 , which results in the release of nuclear factor ... receptor interacting factor NRIF are both recruited to activate c Jun N terminal kinase JNK which ... of nerve growth factor journal Nature volume 354 issue 6352 pages 411 4 year 1991 month December ... nerve growth factor family of structurally conserved proteins. History Rita Levi Montalcini and Stanley ... to reduce neural degeneration. ref Tuszynski M., Blesch A. 2004 . Nerve growth factor from animal models ... 46021 4 url issn chapter Expression of nerve growth factor in the airways and its possible role in asthma ... growth factor and other trophic factors in brain inflammation series Progress in Brain Research ... pmid 14699974 doi 10.1016 S0079 6123 03 46023 8 url issn chapter Nerve growth factor and wound healing ... s disease . ref cite journal author Counts S, Mufson E title The role of nerve growth factor receptors ... growth factor NGF has high levels when people first fall in love , but these levels return to as they were ..., Geroldi D title Raised plasma nerve growth factor levels associated with early stage romantic love ... of eternal life? Science News The Independent Interactions Nerve growth factor has been shown to Protein ...   more details



  1. Fibroblast growth factor

    FGF10 all bind fibroblast growth factor receptor s FGFRs . FGF1 is also known as acidic , and FGF2 is also known as basic fibroblast growth factor . Members FGF11 , FGF12 , FGF13 , and FGF14 , also ... Fibroblast growth factor image PDB 1nun EBI.jpg width caption crystal structure analysis of the fgf10 ... author Olsen SK, Garbi M. et al. title Fibroblast growth factor FGF homologous factors share structural ... JST.JSTAGE endocrj KR07E 002?from PubMed ref Receptors The mammalian fibroblast growth factor ... as it is capable of activating all 7 different FGFRs. In contrast, FGF7 keratinocyte growth factor ... or two heparan sulfate chains. History Fibroblast growth factor was found in pituitary extracts by Armelin ... cite journal author Gospodarowicz D title Localisation of a fibroblast growth factor and its effect ... growth factor FGF1 and basic fibroblast growth factor FGF2 . These proteins had a high degree ... al. title Nuclear activities of basic fibroblast growth factor potentiation of low serum growth mediated ... of fibroblast growth factor receptors ref Promiscuous refers to the biochemistry and pharmacology ... journal author B ttcher RT, Niehrs C. title Fibroblast growth factor signaling during early vertebrate ... C.Z., Schutzman J.L. and Stern M.J. title Fibroblast growth factor signaling in Caenorhabditis elegans ... growth factor VEGF or platelet derived growth factor PDGF . ref cite journal author Vlodavsky Cao R ... Growth Factor s KGF and KGF2, respectively stimulate the repair of injured skin and mucosal ... and functions of fibroblast growth factor 2 FGF 2 in hippocampal formation. Neuroscientist ... of human basic fibroblast growth factor journal Proc. Natl. Acad. Sci. U.S.A. volume 88 issue 8 pages ..., Thomas K title Brain derived acidic fibroblast growth factor complete amino acid sequence and homologies ... factor G CSF granulocyte macrophage colony stimulating factor GM CSF nerve growth factor NGF neurotrophins erythropoietin EPO thrombopoietin TPO myostatin GDF 8 Growth Differentiation factor 9 GDF9 References ...   more details



  1. Basic fibroblast growth factor

    in the form of an increased proliferation after binding to fibroblast growth factor receptor ... growth factor Growth factor Proteases in angiogenesis Receptor biochemistry Signal transduction ...PBB geneid 2247 Basic fibroblast growth factor , also known as bFGF , FGF2 or FGF , ref http www.copewithcytokines.de ... growth factor family. ref name pmid9925931 cite journal author Kim HS title Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping ... url ref Function In normal tissue, basic fibroblast growth factor is present in basement membrane .... title Cardiac specific overexpression of fibroblast growth factor 2 protects against myocardial dysfunction ... embryonic stem cell culture medium the growth factor is necessary for the cells to remain in an undifferentiated ... Basic fibroblast growth factor has been shown to Protein protein interaction interact with casein ... year 2001 month November title Fibroblast growth factor 2 interacts with free ribosomal protein S19 ... D, Vacca A, Rusnati M, Presta M title The discovery of basic fibroblast growth factor fibroblast growth factor 2 and its role in haematological malignancies. journal Cytokine Growth Factor Rev ... chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus ... dimensional structure of human basic fibroblast growth factor. journal Proc. Natl. Acad. Sci. U.S.A. ... growth factor gene expression. journal Ann. N. Y. Acad. Sci. volume 638 issue pages 109 26 year 1992 ... PJ, Sprang SR title Three dimensional structure of human basic fibroblast growth factor, a structural ... growth factor gene FGFB is assigned to chromosome 4q25. journal Cytogenet. Cell Genet. volume ... M, Galland F, Simonetti J, et al. title The human basic fibroblast growth factor gene is located ... Amino terminal sequence of a large form of basic fibroblast growth factor isolated from human benign ... M, Igarashi K title Cloning and expression of cDNA encoding human basic fibroblast growth factor ...   more details



  1. Nerve Growth factor IB

    PBB geneid 3164 The nerve Growth factor IB NGFIB also known as Nur77 or NR4A1 nuclear receptor subfamily ... name pmid2626032 Nerve Growth factor IB is a member of the Nur biology Nur nuclear receptor family ... 90114 3 ref ref name pmid3272167 cite journal author Milbrandt J title Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene journal Neuron volume 1 issue 3 pages 183 8 year ... modification. ref name pmid16339277 Biochemistry Nerve Growth factor IB binds as a monomer or homodimer ... M, Kinowaki K, Noguchi M title Identification of nerve growth factor responsive element of the TCL1 ... T CA repeat, RXR DX, a Sequence motif motif . Evolution and homology Nerve Growth factor IB has the systematic ... and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1 ... in a range of species including neuronal growth factor induced clone B in rat s, Nur77 in mice and TR3 ... Growth factor IB is a signature gene in the metastasis of some primary solid tumours. It is downregulated ... of a human colon nuclear hormone receptor gene related to the NUR 77 NGFI B genes journal Cell Growth ... H, Matt i MG, et al. title Structure, mapping and expression of a growth factor inducible gene encoding ... factor s. ref name pmid2626032 cite journal author Chang C, Kokontis J, Liao SS, Chang Y title Isolation and characterization of human TR3 receptor a member of steroid receptor superfamily journal ... receptor Nur77 journal Mol. Endocrinol. volume 20 issue 4 pages 786 94 year 2006 pmid 16339277 ... receptor subfamily 4, group A, member 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... following inflammatory stimuli. This process is mediated by the NF B nuclear factor kappa B complex, a ubiquitous transcription factor involved in cellular response to stress. ref name pmid16339277 NGFIB ... such as fatty acids, stress, prostaglandins, growth factors, calcium, inflammatory cytokines, peptide ... nuclear receptor and retinoid X receptor RXR in mediating transcription in response to retinoid s. ref ...   more details



  1. Vascular endothelial growth factor A

    KDR, a receptor for vascular endothelial cell growth factor journal J. Biol. Chem. volume 275 issue ... tyrosine kinase, a receptor for vascular endothelial growth factor VEGF journal Oncogene volume 10 ... cells as an isoform specific receptor for vascular endothelial growth factor journal Cell volume ...PBB geneid 7422 Vascular endothelial growth factor A VEGF A is a protein that in humans is encoded by the VEGFA ... D title Assignment of vascular endothelial growth factor VEGF and placenta growth factor PLGF ... This gene is a member of the platelet derived growth factor PDGF vascular endothelial growth factor VEGF family and encodes a protein that is often found as a disulfide linked homodimer. This protein ... DA, Johnson RS title Deletion of vascular endothelial growth factor in myeloid cells accelerates ... M, Lazarovici G, Keshet E title Upregulation of vascular endothelial growth factor expression ... growth factor s effect on the activation of protein kinase C, its isoforms, and endothelial ... endothelial growth factor A165 plasmid followed by granulocyte colony stimulating factor to induce angiogenesis ... endothelial growth factor gene transfer in the prevention of postangioplasty and in stent restenosis ... 19212427 doi 10.1038 gt.2009.4 ref Interactions Vascular endothelial growth factor A has been shown ... S, Kobayashi K, Okada Y title Connective tissue growth factor binds vascular endothelial growth factor ... M title Neuropilin 1 binds vascular endothelial growth factor 165, placenta growth factor 2, and heparin ... See also Vascular endothelial growth factor Bevacizumab or Avastin anti VEGF A human antibody drug. References ... cell growth, promoting cell migration , and inhibiting apoptosis . Alternative splicing ..., have been characterized. ref name entrez cite web title Entrez Gene Vascular endothelial growth factor A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 7422 accessdate ... microvascular permeability and was originally referred to as vascular permeability factor ...   more details




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