gene&dopt full report&list uids 7048 title TGFBR2 transforming growthfactor, beta receptor ...Transforming growthfactor beta TGF is a protein that controls cell growth proliferation , cellular ... growthfactor beta superfamily , which includes activin and inhibin inhibin s, activin ... 301476 glycoproteomic analysis of two mouse mammary cell lines during transforming growthfactor ... mouse mammary cell lines during transforming growthfactor TGF beta induced epithelial to mesenchymal ... cite journal author Herpin A, Lelong C, Favrel P title Transforming growthfactor beta related proteins ... growthfactor beta 2 an unusual fold for the superfamily journal Science volume 257 issue 5068 pages ... HF title Role of transforming growthfactor beta in human disease journal N. Engl. J. Med. volume ... growthfactor beta superfamily association of gene expression with endometrial bleeding journal J. Clin ... title Redox mediated activation of latent transforming growthfactor beta 1 journal Mol. Endocrinol ... title Integrins and the activation of latent transforming growthfactor beta1 an intimate relationship ... growthfactor beta 1 associates to fibroblast extracellular matrix via latent TGF beta binding .... title Human transforming growthfactor beta complementary DNA sequence and expression in normal and transformed ... DB title Latent transforming growthfactor beta TGF beta binding proteins orchestrators of TGF beta ... LE, Leduc R title Processing of transforming growthfactor beta 1 precursor by human furin convertase ... Latent transforming growthfactor beta binding proteins LTBPs structural extracellular matrix proteins for targeting TGF beta action journal Cytokine GrowthFactor Rev. volume 10 issue 2 pages 99 117 .... title Disruption of the gene encoding the latent transforming growthfactor beta binding protein 4 ... growthfactor beta from fibroblast conditioned medium journal J. Cell Biol. volume 106 issue ... Thrombospondin causes activation of latent transforming growthfactor beta secreted by endothelial ... more details
Growth differentiation factors GDFs are a subfamily of proteins belonging to the transforming growthfactor beta superfamily that have functions predominantly in development. ref name herpin cite journal author Herpin A, Lelong C, Favrel P title Transforming growthfactor beta related proteins an ancestral and widespread superfamily of cytokines in metazoans journal Dev Comp Immunol volume 28 issue 5 pages 461 85 year 2004 pmid 15062644 doi 10.1016 j.dci.2003.09.007 ref Types Several members of this subfamily ... of left right patterning in mice by growth differentiation factor 1 journal Nat Genet volume 24 issue ... O Keeffe G, Dockery P, Sullivan A title Effects of growth differentiation factor 5 on the survival ... author Buxton P, Edwards C, Archer C, Francis West P title Growth differentiation factor 5 GDF 5 ..., Swahn M, Hsueh A, Hovatta O title Growth differentiation factor 9 promotes the growth, development ... E, Ib ez C title Growth differentiation factor 11 signals through the transforming growthfactor beta receptor ALK5 to regionalize the anterior posterior axis journal EMBO Rep volume 7 issue 8 pages ..., Hsiao E, McGrath S, Esquela A, Koniaris L title Growth differentiation factor 15 macrophage inhibitory ... S, Huynh T, Lee S title Characterization of growth differentiation factor 15, a transforming growthfactor beta superfamily member induced following liver injury journal Mol Cell Biol volume ... 1 expression independently of Hfe, transferrin receptor 2 Tfr2 , and IL 6 journal Proc Natl Acad ... 6 43 pmc 1609107 ref GDF8 is now officially known as myostatin and controls the growth of muscle ... author Cunningham N, Jenkins N, Gilbert D, Copeland N, Reddi A, Lee S title Growth differentiation factor 10 a new member of the transforming growthfactor beta superfamily related to bone morphogenetic protein 3 journal Growth Factors volume 12 issue 2 pages 99 109 year 1995 pmid 8679252 doi 10.3109 ... of olfactory receptor neurons occurring in the olfactory epithelium , ref cite journal author Wu ... more details
Unreferenced date January 2009 Orphan date February 2009 Hematopoietic growthfactor is a group of proteins that causes blood cells to grow and mature . External links http www.cancer.gov Templates db alpha.aspx?CdrID 44960 Hematopoietic growthfactor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Blood cells Category Protein groups med stub ... more details
PBB geneid 2690 Growth hormone receptor is a protein that in humans is encoded by the GHR gene . ref name entrez cite web title Entrez Gene GHR growth hormone receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2690 accessdate ref GHR orthologs ref name OrthoMaM ... receptor for growth hormone . Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra and intercellular signal transduction pathway leading to growth ... interacts with the ubiquitin dependent endocytosis UbE motif of the growth hormone receptor journal ... Mutation of the SHP 2 binding site in growth hormone GH receptor prolongs GH promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B journal Mol. Endocrinol. volume 14 issue 9 pages 1338 ... required for coupling to the growth hormone receptor journal J. Biol. Chem. volume 270 issue 24 ..., Norstedt G, Carter Su C year 1994 month Aug. title Domains of the growth hormone receptor required ... The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver journal Growth Horm .... Mutations in this gene have been associated with Laron syndrome , also known as the growth ... of the weight of normal siblings , and also show a 40 increase in lifespan. Interactions Growth hormone receptor has been shown to Protein protein interaction interact with SGTA , ref name pmid12735788 ... J year 1998 month Jun. title Grb10 identified as a potential regulator of growth hormone GH signaling by cloning of GH receptor target proteins journal J. Biol. Chem. volume 273 issue 26 pages 15906 ... inhibition of growth hormone stimulated STAT5 signaling by multiple mechanisms journal J. Biol ... 16503281 doi 10.1016 j.ympev.2005.10.017 url issn ref carnivores phylogenetics. Antagonists Growth hormone receptor antagonists such as pegvisomant trade name Somavert are used in the treatment of acromegaly ... et al. title Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice ... more details
M. last4 Cross first4 Michael J. title Vascular endothelial growthfactorreceptor 2 Structure, function ...Vascular endothelial growthfactor VEGF is a signal protein produced by cells that stimulates vasculogenesis ... diseases. VEGF is a sub family of growth factors , to be specific, the platelet derived growthfactor ... The most important member is VEGF A . Other members are Placenta growthfactor PlGF , VEGF B , VEGF ... of vascular endothelial growthfactor D in angiosarcoma patients journal British Journal of Dermatology ... GrowthFactor in Kidney Leads to Progressive Impairment of Glomerular Functions journal Journal ... decrease vascular endothelial growthfactor VEGF production by human luteinized granulosa cells ... links MeshName Vascular Endothelial Growth Factors Proteopedia Vascular Endothelial GrowthFactor the Vascular Endothelial GrowthFactor Structure in Interactive 3D Further reading refbegin 2 ... of Visual Experience on Vascular Endothelial GrowthFactor Expression during the Postnatal Development ... of vascular endothelial growthfactor in angiogenesis journal Acta Haematol. volume 106 issue ... Ria R title Vascular endothelial growthfactor and its receptors in multiple myeloma journal Leukemia ... first5 F last6 Ribatti first6 D cite journal author Caldwell RB title Vascular endothelial growthfactor ... factor vascular endothelial growthfactor in angiogenesis a historical review journal Br. J. Haematol ... growthfactor in cancer journal Cytokine GrowthFactor Rev. volume 16 issue 1 pages 77 89 year 2005 ... Signal transduction via vascular endothelial growthfactor VEGF receptors and their roles in atherogenesis ... Vascular endothelial growthfactor in amyotrophic lateral sclerosis and other neurodegenerative diseases ..., Agrawal DK title Immunomodulatory role of vascular endothelial growthfactor and angiopoietin 1 in airway ... strategies of vascular endothelial growthfactor in renal cell carcinoma journal Clin. Cancer ... Depolymerized hyaluronan induces vascular endothelial growthfactor, a negative regulator of developmental ... more details
Transforming growth interacting factor TGIF is a potential repressor of TGF pathways in myometrial cells. ref name Yen Ping Cite journal author Yen Ping Ho J, Man WC, Wen Y, Polan ML, Shih Chu Ho E, Chen B title Transforming growth interacting factor expression in leiomyoma compared with myometrium journal Fertil. Steril. volume 94 issue 3 pages 1078 1083 year 2009 month June pmid 19524896 doi 10.1016 j.fertnstert.2009.05.001 url pmc 2888713 ref Expression of TGIF is increased in uterine leiomyoma compared with myometrium. ref name Yen Ping References Reflist Category TGF domain ... more details
PBB geneid 3068 Hepatoma derived growthfactor HDGF also known as high mobility group protein 1 like 2 HMG 1L2 is a protein that in humans is encoded by the HDGF gene . ref name pmid8833162 cite journal author Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J title Mapping of the gene encoding the human hepatoma derived growthfactor HDGF with homology to the high mobility group HMG 1 protein to Xq25 journal Genomics volume 32 issue 2 pages 298 300 year 1997 month May pmid 8833162 pmc doi 10.1006 geno.1996.0122 ref ref name entrez cite web title Entrez Gene HDGF hepatoma derived growthfactor high mobility group protein 1 like url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3068 accessdate ref References reflist Further reading refbegin 2 cite journal author Everett AD, Bushweller J title Hepatoma derived growthfactor is a nuclear targeted mitogen. journal Current drug targets volume 4 issue 5 pages 367 71 year 2003 pmid 12816346 doi 10.2174 1389450033490975 cite journal author Nakamura H, Izumoto Y, Kambe H, et al. title Molecular cloning of complementary DNA for a novel human hepatoma derived growthfactor. Its homology with high mobility group 1 protein. journal J. Biol. Chem. volume 269 issue 40 pages 25143 ... derived growthfactor stimulates cell growth after translocation to the nucleus by nuclear localization ... derived growthfactor is involved in lung remodeling by stimulating epithelial growth. journal ... derived growthfactor in hepatocarcinogenesis. journal J. Gastroenterol. Hepatol. volume 18 issue ... Everett AD, Narron JV, Stoops T, et al. title Hepatoma derived growthfactor is a pulmonary endothelial cell expressed angiogenic factor. journal Am. J. Physiol. Lung Cell Mol. Physiol. volume 286 ... of human hepatoma derived growthfactor. journal J. Biomol. NMR volume 29 issue 1 pages 95 6 year ... al. title Hepatoma derived growthfactor as a prognostic marker in completely resected non small cell ... more details
Expression of leukaemia inhibitory factor LIF receptor in human placenta a possible role for LIF in the growth ... that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. ref name entrez cite web title Entrez Gene LIFR leukemia inhibitory factorreceptor ... ref Interactions Leukemia inhibitory factorreceptor has been shown to Protein protein interaction ... gp130 in heterodimerization with the leukemia inhibitory factorreceptor journal Eur. J. Biochem ... Structural and functional studies on the leukemia inhibitory factorreceptor LIF R gene and soluble ... title Oncostatin M binds the high affinity leukemia inhibitory factorreceptor journal New Biol. volume ... factorreceptor is structurally related to the IL 6 signal transducer, gp130 journal EMBO ... H, et al. title Phosphorylation of the human leukemia inhibitory factor LIF receptor by mitogen activated ... inhibitory factorreceptor LIFR gene is located within a cluster of cytokine receptor loci ... the human differentiation stimulating factor leukemia inhibitory factorreceptor journal J. Biochem ... factorreceptor gene and its alternative promoter usage journal J. Biol. Chem. volume 272 issue ... inhibitory factor LIF and LIF receptor in human lung. Distribution and regulation of LIF release journal ... inhibitory factor LIF and LIF receptor LIF R in the human adrenal cortex implications for steroidogenesis ... of leukemia inhibitory factorreceptor degradation by extracellular signal regulated kinase ... factorreceptor component induces the secretion of and is required for functional responses ...PBB geneid 3977 LIFR also known as CD118 C luster of D ifferentiation 118 , is a subunit of a receptor for leukemia inhibitory factor . The PBB Summary template is automatically maintained by Protein Box ... inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation ... through a high affinity receptor complex composed of a low affinity LIF binding chain LIF receptor ... more details
PBB geneid 8074 Fibroblast growthfactor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene . ref name pmid11032749 cite journal author Yamashita T, Yoshioka M, Itoh N title Identification of a novel fibroblast growthfactor, FGF 23, preferentially expressed in the ventrolateral thalamic nucleus of the brain journal Biochem. Biophys. Res. Commun. volume 277 issue 2 pages 494 8 year 2000 month October pmid 11032749 doi 10.1006 bbrc.2000.3696 url issn ref FGF23 is a member of the fibroblast growthfactor FGF family which is responsible for phosphate metabolism. ref name pmid18310961 cite journal author Fukumoto S title Physiological regulation and disorders of phosphate metabolism pivotal role of fibroblast growthfactor 23 journal Intern. Med. volume 47 issue 5 pages 337 43 year 2008 pmid 18310961 doi 10.2169 internalmedicine.47.0730 url issn ref Function Clinical signficance ... FGF23 fibroblast growthfactor 23 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... cite journal author Fukagawa M, Nii Kono T, Kazama JJ title Role of fibroblast growthfactor 23 ..., Econs MJ title Fibroblast growthfactor 23 roles in health and disease. journal J. Am. Soc. Nephrol ... author Liu S, Quarles LD title How fibroblast growthfactor 23 works. journal J. Am. Soc. Nephrol. volume ... M, Miyake A, et al. title Fibroblast growthfactor FGF 23 inhibits renal phosphate reabsorption by activation ... K, Kinosaki M, et al. title Human fibroblast growthfactor 23 mutants suppress Na dependent phosphate ... mutation in fibroblast growthfactor 23 resists proteolytic cleavage and enhances in vivo biological ... S1 specificity for acidic residues and cleaves peptides derived from fibroblast growthfactor ... phosphaturic factor phosphatonin? journal Nephrol. Dial. Transplant. volume 17 issue 6 pages 958 ... S, Muto T, et al. title Cloning and characterization of FGF23 as a causative factor of tumor induced ... PDB Gallery geneid 8074 Growth factors Category Growth factors gene 12 stub ... more details
protein Name ciliary neurotrophic factorreceptor caption image width HGNCid 2170 Symbol CNTFR AltSymbols EntrezGene 1271 OMIM 118946 RefSeq NM 001842 UniProt P26992 PDB ECnumber Chromosome 9 Arm p Band 13 LocusSupplementaryData The ciliary neurotrophic factorreceptor also known as CNTFR binds the ciliary neurotrophic factor . This receptor and its cognate ligand support the survival of neurons . ref name pmid1648265 cite journal author Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD title The receptor for ciliary neurotrophic factor journal Science volume 253 issue 5015 pages 59 63 year 1991 pmid 1648265 doi 10.1126 science.1648265 issn ref This receptor is most closely related to the interleukin 6 receptor . This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage. ref name pmid10812968 cite journal author Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ title The ciliary neurotrophic factor and its receptor, CNTFR alpha journal Pharm Acta Helv volume 74 issue 2 3 pages 265 72 year 2000 pmid 10812968 doi 10.1016 S0031 6865 99 00050 3 issn ref Model organisms class wikitable sortable collapsible collapsed border 1 cellpadding 2 style float right Cntfr knockout mouse phenotype Characteristic Phenotype Homozygote viability bgcolor C40000 Abnormal Recessive lethal study bgcolor 488ED3 Normal Fertility bgcolor 488ED3 Normal Body weight bgcolor 488ED3 Normal Open Field animal test Anxiety bgcolor 488ED3 Normal Neurological assessment bgcolor 488ED3 Normal Grip strength bgcolor 488ED3 Normal Hot plate test Hot plate bgcolor 488ED3 Normal Dysmorphology bgcolor 488ED3 Normal Indirect calorimetry bgcolor 488ED3 Normal Glucose tolerance test bgcolor 488ED3 Normal Auditory brainstem .... ref name mgp reference References Reflist External links MeshName Ciliary Neurotrophic FactorReceptor alpha Subunit membrane protein stub Growthfactor receptors Category Genes mutated in mice ... more details
PBB geneid 5724 The platelet activating factorreceptor is a G protein coupled receptor which binds platelet activating factor . ref name pmid1322356 cite journal author Seyfried CE, Schweickart VL, Godiska R, Gray PW title The human platelet activating factorreceptor gene PTAFR contains no introns ... T title Platelet activating factorreceptor journal Prostaglandins Other Lipid Mediat. volume 68 69 .... supplied by OMIM ref name entrez cite web title Entrez Gene PTAFR platelet activating factorreceptor ... author Shukla SD title Platelet activating factorreceptor and signal transduction mechanisms. journal ... factorreceptor gene expressed in the human heart. journal Biochem. Biophys. Res. Commun. volume ... author Seyfried CE, Schweickart VL, Godiska R, Gray PW title The human platelet activating factorreceptor ... NP, Gerard C title The human leukocyte platelet activating factorreceptor. cDNA cloning, cell surface ... al. title Molecular cloning and expression of platelet activating factorreceptor from human leukocytes ... Expression of human platelet activating factorreceptor gene in EoL 1 cells following butyrate induced ... and tissue distribution of rat platelet activating factorreceptor cDNA. journal Eur. J. Biochem ... platelet activating factorreceptor. journal FEBS Lett. volume 322 issue 2 pages 129 34 year 1993 ... al. title Isolation and properties of platelet activating factorreceptor cDNAs. journal Journal ... mapping of the human platelet activating factorreceptor gene PTAFR to 1p35 p34.3 by fluorescence ... platelet activating factorreceptor. journal FEBS Lett. volume 402 issue 2 3 pages 203 8 year 1997 ... al. title Localization, quantification, and activation of platelet activating factorreceptor in human ... title Platelet Activating FactorReceptor accessdate author authorlink coauthors date format work IUPHAR ... pages language archiveurl archivedate quote MeshName platelet activating factorreceptor NLM ... Summary section title summary text The PAF receptor shows structural characteristics of the rhodopsin ... more details
TNF receptor associated factors also known as TRAFs are a family of protein s primarily involved in the regulation of inflammation , antiviral drug antiviral responses and apoptosis . ref name pmid10623461 cite journal author Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T title Tumor necrosis factorreceptor associated factor TRAF family adapter proteins that mediate cytokine signaling journal Exp. Cell Res. volume 254 issue 1 pages 14 24 year 2000 month January pmid 10623461 doi 10.1006 excr.1999.4733 url issn ref Currently, six TRAF proteins have been characterized in mammals TRAF1 , TRAF2 , TRAF3 , TRAF4 , TRAF5 , TRAF6 . These proteins share a relatively conserved secondary structure , including a namesake C terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptor s and CD40 . See also Tumor necrosis factors References Reflist External links MeshName TRAF Proteins Adaptor proteins Category Proteins biochemistry stub ... more details
PBB geneid 2149 Proteinase activated receptor 1 PAR1 also known as the coagulation factor II thrombin receptor is a protein that in humans is encoded by the F2R gene . ref name pmid8395910 cite journal ... of the receptor. ref name entrez cite web title Entrez Gene F2R coagulation factor II thrombin receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2149 accessdate ref Ligands Several selective antagonists for the PAR1 receptor have been developed ... thrombin receptor gene localization to region q13 of chromosome 5 journal Blood volume 82 issue 5 pages 1532 7 year 1993 month September pmid 8395910 doi url ref PAR1 is a G protein coupled receptor ... receptor References reflist Further reading refbegin 2 PBB Further reading citations cite journal ... receptor. Issues and opportunities journal J. Clin. Invest. volume 89 issue 2 pages 351 5 year 1992 ..., Laurent GJ, Chambers RC title Role of thrombin and its major cellular receptor, protease activated receptor 1, in pulmonary fibrosis journal Biochem. Soc. Trans. volume 30 issue 2 pages 211 6 year 2002 ... receptor PAR 1 in human melanoma journal Oncogene volume 22 issue 20 pages 3130 7 year 2003 pmid 12789289 ... cite journal author Traynelis SF, Trejo J title Protease activated receptor ... VI, Coughlin SR title Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation journal Cell volume 64 issue 6 pages 1057 68 year 1991 pmid ..., et al. title Solid tumor cells express functional tethered ligand thrombin receptor journal Cancer ... mechanism for resensitization of a G protein coupled receptor journal J. Biol. Chem. volume 269 issue ... V, et al. title Crystallographic structures of thrombin complexed with thrombin receptor peptides ... Response of blood leukocytes to thrombin receptor peptides journal J. Leukoc. Biol. volume 54 issue ... Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase ... more details
epidermalgrowthfactor like growthfactor diphtheria toxin receptor journal Biochemistry volume ...PBB geneid 1839 Heparin binding EGF like growthfactor HB EGF is a member of the epidermalgrowthfactor ... E, Klagsbrun M, Greenberg DA title Heparin binding epidermalgrowthfactor like growthfactor hypoxia ... is a specific receptor for heparin binding EGF like growthfactor that mediates cell migration journal ..., Kawarabayashi T, Mekada E title Heparin binding epidermalgrowthfactor like growthfactor as a novel ... MT, Wakefield D title Proliferative effects of heparin binding epidermalgrowthfactor like ... M, Greenberg DA title Heparin binding epidermalgrowthfactor like growthfactor hypoxia inducible ... HB EGF and epidermalgrowthfactor receptors of blastocysts influence embryo uterine interactions ... binding epidermalgrowthfactor like growthfactor increases peripheral glucose disposal and insulin ... of the heparin binding epidermalgrowthfactor like growthfactor gene in vascular endothelial ... to the epidermalgrowthfactor EGF like domain of human heparin binding EGF like growthfactor diphtheria ... K, Higashiyama S, Asada H, et al. title Heparin binding epidermalgrowthfactor like growthfactor ... and the epidermalgrowthfactor EGF like domain of heparin binding EGF like growthfactor for up regulation ... Heparin binding epidermalgrowthfactor like growthfactor is an autocrine mediator of human prostate ... factor is synthesized as a membrane anchored mitogenic and chemotactic glycoprotein . An epidermalgrowthfactor produced by monocytes and macrophages, due to an affinity for heparin is termed HB EGF ... growthfactor journal Cytokine GrowthFactor Rev. volume 15 issue 1 pages 13 9 year 2004 month February ... Raab G, Klagsbrun M title Heparin binding EGF like growthfactor journal Biochim. Biophys. Acta ... M, Andrews GK, Dey SK title Heparin binding EGF like growthfactor gene is induced in the mouse ... 1071 83 year 1994 month May pmid 8026321 doi ref Interactions Heparin binding EGF like growthfactor ... more details
growthfactor TGF beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity ...PBB geneid 7043 Transforming growthfactor beta 3 is a protein that in humans is encoded by the TGFB3 ... TGFB3 transforming growthfactor, beta 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... Transforming growthfactor, beta 3 has been shown to Protein protein interaction interact with TGF beta receptor 2 . ref name pmid12729750 cite journal doi 10.1016 S0022 2836 03 00360 7 last ... D year 2003 month May title Transforming growthfactor beta TGF beta binding to the extracellular ... complex of multiple members of the transforming growthfactor beta superfamily journal J. Biol ... growthfactor beta 3 mRNA by its 5 untranslated region. journal Mol. Cell. Biol. volume 11 ... P, Iwata KK, et al. title Identification of another member of the transforming growthfactor type beta ... al. title A new type of transforming growthfactor beta, TGF beta 3. journal EMBO J. volume 7 issue ... growthfactor beta 1, beta 2 and beta 3 mRNA expression in human cornea. journal Curr. Eye Res. volume ... factor TGF beta isoforms, TGF beta type I III receptor messenger ribonucleic acid and protein, and contains ... and fibromodulin with transforming growthfactor beta. journal Biochem. J. volume 302 issue 2 pages ... cite journal author Djonov V, Ball RK, Graf S, et al. title Transforming growthfactor beta 3 is expressed ... author Jin L, Qian X, Kulig E, et al. title Transforming growthfactor beta, transforming growthfactor beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries. journal ... of the transforming growthfactor beta superfamily. journal J. Biol. Chem. volume 274 issue 2 pages ... DA title Assignment of transforming growthfactor beta1 and beta3 and a third new ligand to the type ... and interaction of connective tissue growthfactor with transforming growthfactor beta in persistent ... DT, Li W title A traffic control role for TGFbeta3 orchestrating dermal and epidermal cell motility ... more details
cite journal author Salomon DS, Bianco C, De Santis M title Cripto a novel epidermalgrowthfactor .... title Identification and biological characterization of an epidermalgrowthfactor related protein ...Orphan date February 2009 PBB geneid 6997 Teratocarcinoma derived growthfactor 1 is a protein that in humans is encoded by the TDGF1 gene . ref name pmid1882841 cite journal author Dono R, Montuori N, Rocchi M, De Ponti Zilli L, Ciccodicola A, Persico MG title Isolation and characterization of the CRIPTO autosomal gene and its X linked related sequence journal Am J Hum Genet volume 49 issue 3 pages 555 65 year 1991 month Oct pmid 1882841 pmc 1683146 doi ref ref name pmid10393436 cite journal author Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG title Assignment of human teratocarcinoma derived growthfactor TDGF sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1 journal Cytogenet Cell Genet volume 84 issue 3 4 pages 220 4 year 1999 month Jul pmid 10393436 pmc doi 10.1159 000015263 ref ref name entrez cite web title Entrez Gene TDGF1 teratocarcinoma derived growthfactor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6997 accessdate ref The PBB Summary template ... 2 H cite journal author Adamson ED, Minchiotti G, Salomon DS title Cripto a tumor growthfactor and more ... Saccone S, Rapisarda A, Motta S, et al. title Regional localization of the human EGF like growthfactor ... journal author Friess H, Yamanaka Y, B chler M, et al. title Cripto, a member of the epidermalgrowthfactor family, is over expressed in human pancreatic cancer and chronic pancreatitis. journal Int ... of transforming growthfactor alpha, amphiregulin and CRIPTO in human normal and malignant breast ... author Reissmann E, J rnvall H, Blokzijl A, et al. title The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. journal Genes Dev. volume ... more details
Witte D, Thomas A, Ali N, et al. title Expression of the vascular endothelial growthfactorreceptor ...PBB geneid 7424 Vascular endothelial growthfactor C is a Vascular endothelial growthfactor VEGF . The human ... encoded by this gene is a member of the platelet derived growthfactor vascular endothelial growthfactor PDGF VEGF family, is active in angiogenesis , lymphangiogenesis ref cite web title Oncogene Vascular endothelial growthfactor receptors in the regulation of angiogenesis and lymphangiogenesis ... and function of this protein is similar to those of vascular endothelial growthfactor D VEGF D . ref cite web title Entrez Gene VEGFC vascular endothelial growthfactor C url http www.ncbi.nlm.nih.gov ... K, Kaipainen A, et al. title A novel vascular endothelial growthfactor, VEGF C, is a ligand for the Flt4 VEGFR 3 and KDR VEGFR 2 receptor tyrosine kinases. journal EMBO J. volume 15 issue 7 pages ... al. title A novel vascular endothelial growthfactor, VEGF C, is a ligand for the Flt4 VEGFR 3 and KDR VEGFR 2 receptor tyrosine kinases. journal EMBO J. volume 15 issue 2 pages 290 98 year 1996 pmid ... human vascular endothelial growthfactor genes VEGF B and VEGF C localize to chromosomes 11q13 ... cite journal author Lee J, Gray A, Yuan J, et al. title Vascular endothelial growthfactor related protein a ligand and specific activator of the tyrosine kinase receptor Flt4. journal Proc. Natl. Acad ... author Dias S, Choy M, Alitalo K, Rafii S title Vascular endothelial growthfactor VEGF C signaling ... growthfactor C expression and invasion phenotype in cervical carcinomas. journal Int. J. Cancer ... of vascular endothelial growthfactor C VEGF C , angiogenesis, lymphangiogenesis, and lymphatic ... doi cite journal author Nakashima T, Kondoh S, Kitoh H, et al. title Vascular endothelial growthfactor ... PW, Shiah SG, Lin MT, et al. title Up regulation of vascular endothelial growthfactor C in breast cancer ... growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes ... more details
Pfam box Symbol IGFBP Name Insulin like growthfactor br binding protein image PDB 1boe EBI.jpg width caption Structure of the IGF binding domain of the insulin like growthfactor binding protein 5 IGFBP 5 . ref name pmid9822601 cite journal author Kalus W, Zweckstetter M, Renner C, et al. title Structure of the IGF binding domain of the insulin like growthfactor binding protein 5 IGFBP 5 implications for IGF and IGF I receptor interactions journal EMBO J. volume 17 issue 22 pages 6558 72 year 1998 month November pmid 9822601 pmc 1171003 doi 10.1093 emboj 17.22.6558 url ref Pfam PF00219 InterPro IPR000867 SMART SM00121 PROSITE PDOC00194 SCOP 1boe TCDB OPM family OPM protein PDB PDB2 1boe , PDB2 1h59 The Insulin like growthfactor binding protein also known as IGFBP serves as a carrier protein for Insulin like growthfactor 1 IGF 1 . ref name pmid10605625 cite journal author Hwa V, Oh Y, Rosenfeld RG title The insulin like growthfactor binding protein IGFBP superfamily journal Endocr. Rev. volume 20 issue 6 pages 761 87 year 1999 month December pmid 10605625 doi 10.1210 er.20.6.761 url issn ref Function Approximately 98 of IGF 1 is always bound to one of 6 binding proteins IGF BP . IGFBP 3, the most abundant protein, accounts for 80 of all IGF binding. IGF 1 binds to IGFBP 3 in a 1 1 molar ratio. IGF BP also binds to IGF 1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF 1. This is important because proliferating IGF 1 IGF BP complex allow growth of the femur and the muscle. fact date May 2011 IGF binding proteins IGFBPs are proteins ... title Role of insulin like growthfactor binding proteins in the control of IGF actions journal Prog. GrowthFactor Res. volume 6 issue 2 4 pages 357 66 year 1995 pmid 8817679 doi 10.1016 0955 2235 ... SM, Pell JM title Potentiation of insulin like growthfactor I IGF I activity by an antibody ... Reflist External links MeshName Insulin like growthfactor binding proteins biochemistry stub Carrier ... more details
. ref name pmid11749962 See also Insulin like growthfactor 2 receptor Insulin like growthfactor II IRES References reflist External links MeshName Insulin Like GrowthFactor II Further reading refbegin .... title Insulin like growthfactor I receptor signal transduction at the interface between physiology ...PBB geneid 3481 Infobox protein family Symbol IGF2 C Name Insulin like growthfactor II E peptide image ... OPM protein CAZy CDD Insulin like growthfactor 2 IGF 2 is one of three protein hormone s that share ... believed to be secreted by the liver and to circulate in the blood. It has growth regulating, insulin like and mitogenic activities. The growthfactor has a major, but not absolute, dependence on somatotropin. It is believed to be a major fetal growthfactor in contrast to IGF 1 Insulin like growthfactor 1 , which is a major growthfactor in adults . ref http www.ncbi.nlm.nih.gov mesh 68007335 ref ... Insulin like growthfactor 2 has been shown to Protein protein interaction interact with IGFBP3 ... factors and affects binding properties of insulin like growthfactor binding protein 3 journal ... S M authorlink coauthors Baxter R C year 1998 month Mar. title Insulin like growthfactor IGF binding ... binding of insulin like growthfactor binding protein 3 journal J. Biol. Chem. volume 273 issue 5 pages ... CA title The insulin like growthfactor insulin system in epithelial ovarian cancer. journal Front ... AW, Duan C, Bern HA title Insulin like growthfactor signaling in fish. journal Int. Rev. Cytol ... DEFAULTSORT Insulin Like GrowthFactor 2 Category Peptide hormones Category Growth factors es Factor ... be mediated by other proteins Function The major role of IGF 2 is as a growth promoting hormone during gestation . IGF 2 exerts its effects by binding to the Insulin like growthfactor 1 receptor IGF 1 receptor . IGF2 may also bind to the Insulin like growthfactor 2 receptor IGF 2 receptor also called the cation independent mannose 6 phosphate receptor , which acts as a signalling antagonist ... more details
is mediated by binding to its specific receptor, the Insulin like growthfactor 1 receptor , abbreviated ... 6 phosphate receptor . The insulin growthfactor II receptor IGF2R lacks signal transduction capacity ... significant insulin like growthfactor I receptor mutations in centenarians journal PNAS date 2008 ... has for its receptor, Insulin like growthfactor 1 receptor IGFR , its binding does not interfere with IGF ...PBB geneid 3479 Insulin like growthfactor 1 IGF 1 is also called somatomedin C is a protein that in humans ... The human gene encoding insulin like growthfactor I is located on chromosome 12 journal Hum. Genet ... JC, Tong PC., Glucose lowering effect of transgenic human insulin like growthfactor I from rice ... serum insulin like growthfactor I concentration journal J Anim Sci volume 77 issue 4 pages 835 9 year 1999 pmid 10328346 ref Insulin like growthfactor 1 receptor IGF 1R and other tyrosine kinase growthfactor receptors signal through multiple pathways. A key pathway is regulated by phosphatidylinositol ... related to a second protein called Insulin like growthfactor 2 IGF 2 . IGF 2 also binds the IGF ... 1R. As the name insulin like growthfactor 1 implies, IGF 1 is structurally related to insulin, and is even ... Growth hormone receptor deficiency is associated with a major reduction in pro aging signaling, cancer ... of serum total testosterone and insulin like growthfactor I in adult men journal Steroids volume ... cite journal author Scarth J title Modulation of the growth hormone insulin like growthfactor GH IGF ... growthfactor I A potential mechanism linking the environment with cancer risk journal British Medical ... author Velcheti V, Govindan R title Insulin like growthfactor and lung cancer journal Journal of thoracic ... pmid17630612 cite journal author Rosenbloom AL title The role of recombinant insulin like growthfactor ... allows the growthfactor to have an increased half life in serum. Without binding to IGFBP 3 ... Interactions Insulin like growthfactor 1 has been shown to bind and interact with all the IGF 1 Binding ... more details
growthfactor VEGF receptor 1 and its ligand VEGF B in motor neuron degeneration journal J. Neurosci ... growthfactor B VEGF B binds to VEGF receptor 1 and regulates plasminogen activator activity ... K, Lambrechts D et al. title Novel Role for Vascular Endothelial GrowthFactor VEGF Receptor 1 ... growthfactor B VEGF B binds to VEGF receptor 1 and regulates plasminogen activator activity in endothelial ...PBB geneid 7423 Vascular endothelial growthfactor B also known as VEGF B is a protein that, in humans ... growthfactor B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 7423 accessdate ref VEGF B is a growthfactor that belongs to the vascular endothelial growthfactor ... endothelial growthfactor B deficient mice journal J. Cereb. Blood Flow Metab. volume 24 ... growth factors journal Mol. Divers. volume 10 issue 4 pages 515 27 year 2006 month November pmid 16972015 doi 10.1007 s11030 006 9027 3 url issn ref Interactions Vascular endothelial growthfactor ... endothelial growthfactor B splice and proteolytic isoforms to neuropilin 1 journal J. Biol. Chem. volume ... Vascular endothelial growthfactor B, a novel growthfactor for endothelial cells. journal Proc. Natl ... of the mouse and human genes for vascular endothelial growthfactor B VEGF B and characterization ... T, et al. title Differential binding of vascular endothelial growthfactor B splice and proteolytic ... matrix tenascin X in combination with vascular endothelial growthfactor B enhances endothelial ... al. title Comparative expression of vascular endothelial growthfactor family members, VEGF B, C and D ... Crystal structure of human vascular endothelial growthfactor B identification of amino acids important ... Iodide inhibits vascular endothelial growthfactor A expression in cultured human thyroid follicles ..., Watts RJ, Li X title VEGF B is dispensable for blood vessel growth but critical for their survival ... 08.2008 url issn ref VEGF B exerts its effects via the FLT1 receptor. ref name pmid16972015 cite ... more details
PBB geneid 2277 C fos induced growthfactor FIGF or vascular endothelial growthfactor D , VEGF D is a vascular endothelial growthfactor that in humans is encoded by the FIGF gene . ref name entrez cite web title Entrez Gene FIGF c fos induced growthfactor vascular endothelial growthfactor D url http ... derived growthfactor vascular endothelial growthfactor PDGF VEGF family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex ... growthfactor C. ref name entrez Tumor metastasis to lymph nodes Lymph node metastasis is very ... to the platelet derived growthfactor vascular endothelial growthfactor family journal Proc. Natl ... , pmc 38117 cite journal title Molecular cloning of a novel vascular endothelial growthfactor, VEGF ... , last4 Suyama first4 A last5 Sugano first5 S cite journal title Vascular endothelial growthfactor D VEGF D is a ligand for the tyrosine kinases VEGF receptor 2 Flk1 and VEGF receptor 3 Flt4 journal ... Biosynthesis of vascular endothelial growthfactor D involves proteolytic processing which generates ... endothelial growthfactor D in breast carcinoma with long term follow up journal Clin. Cancer Res ... title Vascular endothelial growthfactor D is an independent prognostic factor in epithelial ovarian ... endothelial growthfactor D is associated with lymph node metastasis in human colorectal carcinoma ... growthfactor D mRNA stability journal J. Biol. Chem. volume 278 issue 45 pages 44650 6 year 2004 ... separator , pmc 1368959 cite journal title Impact of vascular endothelial growthfactor C and D ... specific characterization of the vascular endothelial growthfactor axis in prostate cancer expression ... separator , cite journal title Plasmin Activates the Lymphangiogenic Growth Factors VEGF C and VEGF ... R pmc 528928 cite journal title The lymphangiogenic growth factors VEGF C and D are ligands for the integrin ... X stub Growth factors The PBB Controls template provides controls for Protein Box Bot, please see Template ... more details
PBB geneid 2692 The growth hormone releasing hormone receptor GHRHR is a G protein coupled receptor that binds growth hormone releasing hormone . The GHRHR activates a Gs protein that causes a cascade ... Gaylinn BD title Growth hormone releasing hormone receptor journal Recept. Channels volume 8 issue ... section title summary text This gene, expressed in the pituitary, encodes a receptor for growth hormone releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone . Mutations in this gene have been associated with isolated growth hormone deficiency ... BD title Molecular and cell biology of the growth hormone releasing hormone receptor. journal Growth ... and expression of a pituitary specific receptor for growth hormone releasing hormone. journal ... growth hormone releasing hormone receptor in human pituitary adenomas. journal J. Clin. Endocrinol ..., Zysk JR, et al. title Molecular cloning and expression of a human anterior pituitary receptor for growth ... MO title Assignment of the human growth hormone releasing hormone receptor gene GHRHR to 7p14 by in situ ... in the human growth hormone releasing hormone receptor causes growth failure analogous to the little ... Structure and regulation of the human growth hormone releasing hormone receptor gene. journal Mol ... caused by an inactivating mutation in the growth hormone releasing hormone receptor Dwarfism ... al. title Familial dwarfism due to a novel mutation of the growth hormone releasing hormone receptor ... presence of the growth hormone releasing hormone receptor to somatotropes in rat and human pituitaries ... new mutations in the gene for the growth hormone gh releasing hormone receptor in familial isolated ... characterized to date. ref name entrez cite web title Entrez Gene GHRHR growth hormone releasing hormone receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ..., Schally AV, Zar ndi M, Groot K title Inhibition of GH release of rats by new potent antagonists of growth ... more details
Infobox rfam Name Insulin like growthfactor II IRES image RF00483.jpg width caption Predicted secondary structure and sequence conservation of IRES IGF2 Symbol IRES IGF2 AltSymbols Rfam RF00483 miRBase miRBase family RNA type Cis regulatory element Cis reg Internal ribosome entry site IRES Tax domain Eukaryota GO GO 0043022 SO SO 0000243 CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData The insulin like growthfactor II IGF II internal ribosome entry site Internal ribosome entry site IRES is found in the 5 UTR of Insulin like growthfactor 2 IGF II leader 2 mRNA . This cis regulatory element RNA element allows cap independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF II production in rapidly dividing cells during development. ref cite journal last Pedersen first SK coauthors Christiansen J, Hansen TO, Larsen MR, Nielsen FC year 2002 title Human insulin like growthfactor II leader 2 mediates internal initiation of translation journal Biochem J volume 363 pages 37&ndash 44 pmid 11903044 doi 10.1042 0264 6021 3630037 issue Pt 1 pmc 1222448 ref References reflist 1 External links Rfam id RF00483 name Insulin like growthfactor II IRES http iresite.org IRESite web.php?page view&entry id 337 IRESite page for IGF2 leader2 Category Cis regulatory RNA elements molecular cell biology stub ... more details
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