Drugbox IUPAC name 2 4 methoxyphenyl 3,4 dihydronaphthalen 1 yl 4 2 pyrrolidin 1 ylethoxy phenyl methanone image Trioxifene.png Clinical data tradename pregnancy category legal status Uncontrolled routes of administration Oral Pharmacokinetic data bioavailability metabolism elimination half life excretion Identifiers CAS number 63619 84 1 ATC prefix none ATC suffix PubChem 50139 ChemSpiderID 45471 UNII Ref fdacite correct FDA UNII R0130F043H synonyms Chemical data C 30 H 31 N 1 O 3 molecular weight 453.57 g mol Trioxifene LY 133,314 is a selective estrogen receptor modulator SERM with competitive inhibition competitive binding molecular binding activity chemistry activity against estradiol for estrogen receptor alpha ER alpha and receptor antagonist antagonistic activity against ER alpha mediated gene expression . It has demonstrated anticancer effects in animal studies, ref name pmid14522935 cite journal author Neubauer BL, McNulty AM, Chedid M, Chen K, Goode RL, Johnson MA, Jones CD, Krishnan V, Lynch R, Osborne HE, Graff JR title The selective estrogen receptor modulator trioxifene LY133314 inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model journal Cancer Research volume 63 issue 18 pages 6056 62 year 2003 month September pmid 14522935 doi url ref indicating that it may be useful for the treatment of breast cancer . See also Selective estrogen receptor modulator References Reflist Estrogenics Category Dilines Category Pyrrolidines Category Selective estrogen receptor modulators Category Aromatic ketones Category Phenols Category Phenol ethers pharmacology stub ... more details
bleeding is likely due to hormonal fluctuations. The body is pre programmed to make certain estrogen levels each day and the estrogen and some additional hormones like Follicle stimulating hormone FSH ... estrogen. These excess estrogen levels can cause pre period bleeding bleeding through . This should ... and not developed endometrium. Keep in mind that the usage of combined estrogen and progesterone eliminates .... This is because the dosage of estrogen in the OCs pills is much lower than the quantity produced ... by using a pill with a higher estrogen which will stimulate further proliferation of the endometrium ... more details
of estrogen for Hormone replacement therapy menopause hormone replacement therapy in the United States of America. Estrone is the major estrogen in Premarin about 50 and equilin is present as about 25 of the total. Estrone is a major estrogen that is normally found in women. Equilin is not normally ... , modified chemical forms in which the active estrogen is coupled to another chemical group such as sulfate . Estrone sulfate is usually the major form of estrogen in women. After being taken ... to be the major active estrogen in women. References Reflist Estrogenics Category Estrogens Category ... more details
Progestin challenge , or progesterone withdrawal test is a test used in the field of obstetrics and gynecology in order to evaluate a patient who is experiencing amenorrhea . Due to readily available assays to measure serum estradiol levels, this test is now rarely used. ref cite web url http emedicine.medscape.com article 276110 diagnosis title eMedicine Amenorrhea, Secondary Differential Diagnoses & Workup accessdate 2010 05 02 publisher eMedicine.com ref The test is performed by administering progesterone orally in the form of medroxyprogesterone acetate Provera , or intramuscularly. If the patient has sufficient serum estradiol greater than 50 pg mL then withdrawal bleeding should occur 2 7 days after the progestin is finished, indicating that the patient s amenorrhea is due to anovulation . However, if no bleeding occurs after progesterone withdrawal, then the patient s amenorrhea is likely to be due to either a low serum estradiol, b hypothalamic pituitary axis dysfunction or c a problem with the uterine outflow tract, such as stenosis of uterine cervix cervical stenosis or uterine synechiae Asherman s syndrome . In order to distinguish between hypoestrogenism or a uterine outflow tract problem, estrogen may be administered followed by a course of progestin in order to induce withdrawal bleeding. If the patient experiences withdrawal bleeding with the combined estrogen progestin therapy, then the amenorrhea is likely due to low estrogen. ref cite web url http www.advancedfertility.com progesterone withdrawal test.htm title Progesterone Withdrawal Test accessdate 2010 05 02 publisher Advanced Fertility Center of Chicago ref References reflist Category Female genital procedures ... more details
in men. Aromatase is the enzyme which synthesizes estrogen . As breast and ovarian cancers require estrogen to grow, AIs are taken to either block the production of estrogen or block the action of estrogen on receptors. Types of AIs There are 2 types of aromatase inhibitors AIs approved ... Arimidex , inhibits the synthesis of estrogen via reversible competition for the aromatase enzyme ... converts androgen s into estrogen s by a process called aromatization. As breast tissue is stimulated ... tissue. The main source of estrogen is the ovaries in premenopausal women, while in post menopausal women most of the bodies estrogen is produced in the conversion of androgens to estrogen by the aromatase ... a few CNS sites in various regions within the brain . Estrogen is produced and acts locally via action of the aromatase enzyme in these tissues, but any circulating estrogen, which exerts Systemic circulation systemic estrogenic effects in men and women, is the result of estrogen escaping Hydroxylation ... 0760 03 00360 1 author Simpson ER title Sources of estrogen and their importance journal The Journal ... most of the estrogen is produced in the ovary ovaries , in postmenopausal women estrogen is mainly ... respond to estrogen, lowering estrogen production at the site of the cancer i.e. the adipose tissue ... women, the decrease in estrogen activates the hypothalamus and pituitary axis to increase gonadotropin ... hormonal therapy in postmenopausal women with breast cancer. Although tamoxifen Selective estrogen ... cancer that is estrogen receptor positive. Investigational off label File WBMaromatase.jpg right ... their elevated levels of testosterone from being converted to excess estrogen. Although anastrozole ..., only the selective estrogen receptor modulator , tamoxifen , has been shown to be more successful ... etiological differences in steroid induced gynecomastia excess estrogen and pubertal gynecomastia ..., showing the acute anti estrogen action of tamoxifen on the affected tissue provides faster relief ... more details
Unreferenced stub auto yes date December 2009 Sex hormone receptor s belong to the group of steroid hormone receptor s and interact with sex hormones . Three sex hormone steroid receptors can be distinguished Androgen receptor s Estrogen receptor s Progesterone receptor s Transcription factors g2 DEFAULTSORT Sex Hormone Receptor Category Intracellular receptors Cell biology stub es Receptor de hormonas sexuales ... more details
cancers require estrogen to grow. Those cancers have estrogen Receptor biochemistry receptors ERs , and are called ER positive. They may also be called estrogen responsive, hormonally responsive, or hormone receptor positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers ... in addition to surgery and or radiation in post menopausal women. The main source of estrogen is the ovaries in premenopausal women, while in post menopausal women most of the body s estrogen is produced via the conversion of androgen s into estrogen by the aromatase enzyme in the peripheral tissues i.e. adipose tissue like that of the breast and a number of sites in the brain. Estrogen is produced .... Any circulating estrogen in post menopausal women as well as men is the result of estrogen escaping ... Sources of estrogen and their importance journal The Journal of Steroid Biochemistry and Molecular Biology ... ever completing their task of converting androgens into estrogens. The estrogen suppression rate for exemestane ... medicine indicated for the adjuvant treatment of postmenopausal women with estrogen receptor ... estrogen receptor positive unknown receptor status breast in a large well designed trial. Preliminary ... more details
An antiestrogen is a substance that blocks the production or utilization of estrogens , ref name urlDefinition of antiestrogen NCI Dictionary of Cancer Terms, Definition of antiestrogen NCI Dictionary of Cancer Terms cite web url http www.cancer.gov dictionary ?CdrID 44813 title Definition of antiestrogen NCI Dictionary of Cancer Terms, Definition of antiestrogen NCI Dictionary of Cancer Terms format work accessdate , ref or inhibits their effects. ref DorlandsDict one 000006027 antiestrogen ref Estrogens are the family of hormones that promote the development and Maintenance of an organism maintenance of female sex characteristics . Antiestrogens like tamoxifen can promote an invasive phenotype in estrogen receptor Breast cancer classification ER positive breast cancer cells with deficient Cell adhesion intercellular adhesion . Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class. ref name pmid16112269 cite journal author Riggins RB, Bouton AH, Liu MC, Clarke R title Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer journal Vitam. Horm. volume 71 issue pages 201 37 year 2005 pmid 16112269 doi 10.1016 S0083 6729 05 71007 4 url http linkinghub.elsevier.com retrieve pii S0083 6729 05 71007 4 ref Aromatase inhibitors reduce the production of estrogen, while the term antiestrogen is usually reserved for agents reducing the response to estrogen. See also Selective estrogen receptor modulator National Collegiate Athletic Association NCAA Published list of banned drug for the usage to student athletes.Examples of anti estrogens are anastrozole, clomiphene, tamoxifen, and formestane. References Reflist External links http www.reutershealth.com archive 2009 01 02 professional links 20090102clin030.html NCI cancer dict Estrogenics Category Hormonal agents Category Hormonal antineoplastic drugs antineoplastic drug stub es Antiestr geno ... more details
ATD may refer to 1,4,6 Androstatrien 3,17 dione , estrogen inhibitor. Acute Tryptophan Depletion. Against the Day , a Thomas Pynchon novel. Anthropomorphic Test Device crash test dummy . Azimuth thruster Azimuth tractor drive , a drive system for tugboats. The Unix daemon handling at Unix at commands. Above threshold dissociation , a phenomenon in optics . Attention To Detail , a British game development studio that liquidated in late 2003. Actual Time of Departure disambig de ATD fr ATD it ATD ... more details
Wikify date January 2011 Christian Pike is an Associate Professor at the Leonard Davis School of Gerontology and a member of the USC Neuroscience Program. His ongoing work focuses on Alzheimer s disease and other age related neurodegenerative disorders. His laboratory studies the role of neuronal apoptosis in neural diseases. Recently, his research found new use for synthetic estrogens in lessening the effects of Hormone Replacement Therapy for Alzheimer s patients. ref http www.usc.edu uscnews stories 14782.html Article on Synthetic Estrogen Use ref In 2000, he won the Turken Award from the Alzheimer s Association. Selected Papers and Publications Pike CJ 1999 Estrogen modulates neuronal Bcl xL expression and b amyloid induced apoptosis relevance to Alzheimer s disease J Neurochem 72 1552 1563. Stoltzner SE, Berchtold NC, Cotman CW and Pike CJ 2001 Estrogen regulates bcl x expression in rat hippocampus. Neuroreport 12 2797 2800.. Pike CJ 2001 Testosterone attenuates b amyloid toxicity in cultured hippocampal neurons Brain Res. 919 160 165. Berchtold NC, Kesslak J.P., Pike CJ and Cotman CW 2001 Estrogen and exercise interact to regulate brainderived neurotrophic factor BDNF gene expression in the hippocampus Eur J Neurosci 14 1992 2002. External links http www.usc.edu dept gero University of Southern California Davis School of Gerontology References reflist Persondata Metadata see Wikipedia Persondata . NAME Pike, Christian ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Pike, Christian Category American scientists Category Living people ... more details
DISPLAYTITLE C sub 18 sub H sub 18 sub O sub 2 sub The molecular formula C sub 18 sub H sub 18 sub O sub 2 sub molar mass 266.33 g mol, exact mass 266.13068 may refer to Dienestrol , a synthetic estrogen Equilenin , a horse steroid Honokiol Magnolol MolFormDisambig ... more details
. The primary hormone that causes these changes is estrogen . Estrogen and progesterone A hormonal imbalance occurs as a reaction to the elevated level of estrogen and lowered level of progesterone within a woman s body. Estrogen is naturally produced by the ovaries and is the female hormone necessary ... the body during childbearing years. Estrogen is dominant during the follicular phase of the menstrual ... their production of estrogen and progesterone, causing symptoms of hormone imbalance to develop. Estrogen replacement therapy is a common treatment for hormone imbalance. Frequently, only estrogen ... it is important to supplement progesterone as well, as the balance between estrogen and progesterone is important. Estrogen dominance , in which there is too much estrogen relative to progesterone, can ... due to estrogen dominance or increased amounts of estrogen in the body and not enough ... or estrogen. Menstruation is less frequent and eventually stops altogether. It is a biology biological .... The first is estrogen replacement. It is available in tablet form, cream, or a patch. It is administered ... is a combination of estrogen and progesterone. It is commonly known as HRT combination therapy. These two ... more details
Vaginally administered estrogens are estrogen s that are delivered by intravaginal administration , thereby exerting their effects mainly in the nearby tissue, with more limited systemic effect s compared to orally administered estrogens. ref name mayo2011 http www.mayoclinic.com health drug information DR602127 Estrogen Vaginal Route from Mayo Clinic Thomson Healthcare Inc. Portions of this document last updated Nov. 1, 2011 ref For menopausal hormone replacement therapy When used for Hormone replacement therapy menopause menopausal hormone replacement therapy , vaginally administered estrogens are intended to decrease the uncomfortable effects on the vagina, vulva and urethra that are caused by the decrease in estrogen production in the body after menopause, such as Atrophic vaginitis , with presentations such as dryness and soreness in the vagina and dyspareunia pain during sexual intercourse ref name mayo2011 Itching, redness, or soreness of the vulva ref name mayo2011 Urinary urgency feeling an urge to urinate more often than is needed , or dysuria experiencing pain while urinating ref name mayo2011 Examples Vaginal tablets , including Vagifem which contains estradiol ref http www.vagifem.com Vagifem Manufacturer s website ref Vaginal cream , including Premarin which is a compound cream ref http www.fda.gov Safety MedWatch SafetyInformation Safety RelatedDrugLabelingChanges ucm121062.htm Premarin conjugated estrogens Vaginal Cream Detailed View Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research CDER November 2008 ref consisting primarily of conjugated estrogen s isolated from horse mare s urine . Another vaginal cream is Ovesterin , which contains estriol . Vaginal ring s , which are polymeric drug delivery devices designed to provide controlled release of drugs to the vagina over extended periods of time. References reflist Category Menopause ... more details
main Oral contraceptive formulations Estrostep is the brand name for a female combined oral contraceptive pill , distributed by Warner Chilcott. It is the first of its kind in that it is the only oral contraceptive that changes estrogen levels while keeping progestin levels constant. The estrogen doses are as follows 20 g for 5 days, 30 g for 7 days and 35 g for 9 days. ref http www.wcrx.com products estrostep . Estrostep FAQ, Warner Chilcott ref In addition, the 7 placebo pills contain iron to help replace what is lost during the pill period. Studies have shown that it helps significantly with acne. ref http www.centerwatch.com patient drugs dru707.html Newly Approved Drug Therapies 707 Estrostep ethinyl estradiol and norethindrone acetate , Pfizer Bot generated title ref References references Birth control methods Hormonal contraceptives Category Personal care brands Category Hormonal contraception pharma stub ... more details
unreferenced date October 2011 Fern test refers to detection of a characteristic fern like pattern of cervical mucus when a specimen of cervical mucus is allowed to dry on a glass slide and is viewed under a low power microscope. Fern test is used to provide indirect evidence of ovulation and fertility, however this test does not predict the time of ovulation. Ferning is due to the presence of sodium chloride in the mucus under estrogen effect. When high levels of estrogen are present, just before ovulation, the cervical mucus forms fern like patterns due to crystallization of sodium chloride on mucus fibers. This pattern is known as arborization or ferning . When progesterone is the dominant hormone, as is just after ovulation, fern pattern is no longer discernible. Fern pattern is completely absent by 22nd day of cycle. Disappearance of fern pattern after 22nd day suggests ovulation and its persistence throughout menstrual cycle suggests an ovulation infertility . Category Medical tests Category Gynaecology ... more details
orphan date February 2012 PBB geneid 55082 ARGLU1 also known as arginine and glutamate rich 1 is a human gene at 13q33.3. ref name entrez cite web title Entrez Gene ARGLU1 arginine and glutamate rich 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 55082 accessdate ref The protein product of this gene has been proposed as a MED1 interacting protein required for estrogen dependent gene transcription and breast cancer cell growth ref cite journal last Zhang first D coauthors Jiang, P, Xu, Q, Zhang, X title Arginine and glutamate rich 1 ARGLU1 interacts with mediator subunit 1 MED1 and is required for estrogen receptor mediated gene transcription and breast cancer cell growth. journal The Journal of biological chemistry date 2011 May 20 volume 286 issue 20 pages 17746 54 pmid 21454576 ref . References reflist Category Human genetics ... more details
enzyme Name estrone sulfotransferase EC number 2.8.2.4 CAS number 9026 06 6 IUBMB EC number 2 8 2 4 GO code 0004304 image width caption In enzymology , an estrone sulfotransferase EC number 2.8.2.4 is an enzyme that catalysis catalyzes the chemical reaction 3 phosphoadenylyl sulfate estrone math rightleftharpoons math adenosine 3 ,5 bisphosphate estrone 3 sulfate Thus, the two substrate biochemistry substrates of this enzyme are 3 phosphoadenylyl sulfate and estrone , whereas its two product chemistry products are adenosine 3 ,5 bisphosphate and estrone 3 sulfate . This enzyme belongs to the family of transferase s, to be specific, the sulfotransferases, which transfer sulfur containing groups. The systematic name of this enzyme class is 3 phosphoadenylyl sulfate estrone 3 sulfotransferase . Other names in common use include 3 phosphoadenylyl sulfate estrone 3 sulfotransferase , estrogen sulfotransferase , estrogen sulphotransferase , oestrogen sulphotransferase , and 3 phosphoadenylylsulfate oestrone sulfotransferase . This enzyme participates in androgen and estrogen metabolism and sulfur metabolism . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1AQU , PDB link 1AQY , PDB link 1BO6 , PDB link 1G3M , and PDB link 1HY3 . References reflist 1 cite journal author Adams JB, Poulos A date 1967 title Enzymic synthesis of steroid sulphates. 3. Isolation and properties of estrogen sulphotransferase of bovine adrenal glands journal Biochim. Biophys. Acta. volume 146 pages 493&ndash 508 pmid 4965224 issue 2 cite journal author Rozhin J, Zemlicka J and Brooks SC date 1967 title Studies on bovine adrenal estrogen sulfotransferase. Inhibition and possible involvement of adenine estrogen stacking journal J. Biol. Chem. volume 252 pages 7214&ndash 7220 cite journal author Adams JB, Ellyard RK, Low J date 1974 title Enzymic synthesis of steroid sulphates. IX. Phys ... more details
with the observational study . The 4 interventions and their abbreviated terminology are Estrogen progestin versus placebo This phase studied estrogen , specifically conjugated equine estrogen, plus ... healthy postmenopausal women. This trial found that, compared with placebo, women receiving estrogen ... in 2002 when the researchers found that the subjects with estrogen plus progestin had a greater incidence ... Group for the Women s Health Initiative Investigators title Risks and Benefits of Estrogen Plus ... Breast cancer after use of estrogen plus progestin in postmenopausal women url http content.nejm.org ... of Medicine NEJM doi 10.1056 NEJMoa0807684 issue 6 ref Conjugated estrogen versus placebo This trial studied estrogen , specifically conjugated equine estrogen Premarin , Wyeth , alone versus placebo ... so that estrogen could be administered without a progestin. In women with a uterus, a progestin is needed to counteract the risk of endometrial cancer posed by unopposed estrogen. Major results of this study were that, compared with placebo, women receiving estrogen alone experienced ref name ... animals as indicating that administration of an estrogen supplement to postmenopausal women would ... The estrogen that was administered in the WHI studies was conjugated equine estrogen CEE . This consists ... and WHI estrogen trial results describes potential explanations for the conflicting results. In addition ... with CEE was associated with a slightly increased risk of breast cancer. Some benefits of using an estrogen ... studies. For example, other forms of estrogen such as esterified estrogens or topical administration ..., hormone therapy, and venous thromboembolism among postmenopausal women impact of the route of estrogen ... RL, et al. title Risks and benefits of estrogen plus progestin in healthy postmenopausal women principal ... GL, Limacher M, Assaf AR, et al. title Effects of conjugated equine estrogen in postmenopausal women ... more details
remains unknown. ref name estrogen Citation last Bhandari first Ramji Kumar title Evidence That Estrogen ... estrogen Citation last Bhandari first Ramji Kumar title Gonadal restructuring and correlative steroid ... Science volume 21 pages 305 310 date year 2004 ref ref name zhou Estrogen s E2 role Females only change ... change. In fish, it is conclusive that estrogen has a direct effect on ovarian differentiation and is needed to maintain overall ovarian development. ref name estrogen Biosynthesis of estrogen ..., the levels of Estrogen decrease and even immature females turn into males. However, if AI is given ... role in maintaining a female gender in the Honeycomb grouper fish. Lack of Estrogen causes degradation ... more details
Infobox Disease Name Atrophic vaginitis Image Caption DiseasesDB 32516 ICD10 ICD10 N 95 2 n 80 ICD9 ICD9 627.3 ICDO OMIM MedlinePlus 000892 eMedicineSubj eMedicineTopic MeshID Atrophic vaginitis also known as vaginal atrophy or urogenital atrophy is an inflammation of the vagina and the outer urinary tract due to the thinning and shrinking of the tissues, as well as decreased lubrication. This is all due to a lack of the reproductive hormone estrogen . The most common cause of vaginal atrophy is the decrease in estrogen which happens naturally during perimenopause, and increasingly so in post menopause . However this condition can sometimes be caused by other circumstances. The symptoms can include vaginal soreness and itching, as well as painful intercourse, and bleeding after sexual intercourse. The shrinkage of the tissues can be extreme enough to make intercourse impossible. Symptoms and signs Genital symptoms include dryness, itching, burning, soreness, pressure, white discharge, malodorous discharge due to infection, painful sexual intercourse, bleeding after intercourse. In addition, sores and cracks may occur spontaneously. Atrophic vaginitis is a cause of Postmenopausal bleeding PMB . Urinary symptoms include painful urination, blood in the urine, increased frequency of urination, incontinence, and increased likelihood and occurrence of infections. Incidence and causes A large number of postmenopausal women who are not using topical estrogen have at least some degree of vaginal atrophy however, many women do not actively ask that medical attention be paid to this, possibly because it is naturally caused, or because of the taboo that still exists surrounding aging and sexuality. Citation needed date January 2010 The cause of vaginal atrophy is usually the normal decrease in estrogen as a result of menopause. Other causes of decreased estrogen levels are decreased ovarian functioning due to radiation therapy or chemotherapy, immune disorder, removal of the ov ... more details
estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Estradiol ... receptor . After the estrogen receptor has bound its ligand , estradiol can enter the cell nucleus ... upon the target cell. Estradiol binds well to both estrogen receptors, ER , and ER , in contrast .... These medications are called selective estrogen receptor modulator s, or SERMs. Estradiol is the most potent naturally occurring estrogen. Metabolism In plasma, estradiol is largely bound to sex hormone ... estrogen in women with amenorrhea or menstrual dysfunction, and to detect the state of hypoestrogenicity and menopause . Furthermore, estrogen monitoring during fertility therapy assesses follicular growth and is useful in monitoring the treatment. Estrogen producing tumors will demonstrate persistent ... pregnancy , estrogen levels, including estradiol, rise steadily toward term. The source of these estrogens ... increases due to placenta l production. In baboons, blocking of estrogen production leads to pregnancy ... in many parts of the world, and estrogen exposure in the environment has been postulated to be the cause ... estrogen deficiency. Liver Estradiol has complex effects on the liver. It can lead to cholestasis ... pituitary system to regulate gonadotropin s. Estrogen is considered to play a significant role ... drops or fluctuations in, or long periods of sustained low levels of estrogen may be correlated ... was shown to be effective after levels of estrogen were stabilized and or restored. ref cite journal author Douma SL, Husband C, O Donnell ME, Barwin BN, Woodend AK title Estrogen related mood ... Blood vessels Estrogen affects certain blood vessels. Improvement in arterial blood flow has been ... Circulation volume 92 issue 1 pages 24 30 year 1995 pmid 7788912 ref Oncogene Estrogen is suspected ... more details
PBB geneid 6783 Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene . ref name pmid7961757 cite journal author Bernier F, Leblanc G, Labrie F, Luu The V title Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene journal J Biol Chem volume 269 issue 45 pages 28200 5 year 1994 month Dec pmid 7961757 pmc doi ref ref name entrez cite web title Entrez Gene SULT1E1 sulfotransferase family 1E, estrogen preferring, member 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6783 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure number and length of exons is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. ref name ... of a cDNA for human liver estrogen sulfotransferase journal J. Steroid Biochem. Mol. Biol ... author Aksoy IA, Wood TC, Weinshilboum R title Human liver estrogen sulfotransferase identification ... S, et al. title Human estrogen sulfotransferase gene STE cloning, structure, and chromosomal localization ... RM title Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase immunochemical ... localization and regulation of expression of testicular estrogen sulfotransferase journal Endocrinology ... LC, Petrotchenko E, Shevtsov S, Negishi M title Crystal structure of the human estrogen sulfotransferase ... analysis of a hydroxylated polychlorinated biphenyl OH PCB bound to the catalytic estrogen binding site of human estrogen sulfotransferase journal Environ. Health Perspect. volume 111 issue 7 pages 884 ... more details
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