portion of the complete protein . However, the term exon is often misused to refer only ... in human genes Exon References Zhang 1998 . File Gene structure.svg right To the right is a diagram ... the same exon structure, since parts of the mRNA could be removed by the process of alternative ... coding RNA . Exonization is the creation of a new exon, as result of mutations in intron ic sequences ... Exon trapping or gene trapping is a molecular biology technique that exploits the existence of the intron exon RNA splicing splicing to find new genes. The first exon of a trapped gene splices into the exon that is contained in the insertional DNA . This new exon contains the ORF for a reporter gene ... example Exon shuffling Interrupted gene Intron mRNA Untranslated region UTR References reflist General ... wiktionary exon http wormweb.org exonintron Exon intron graphic maker Post transcriptional modification Category DNA Category Spliceosome Category RNA splicing ar ca Ex cs Exon de Exon es Ex n eu Exoi fa fr Exon gl Ex n ko it Esone he hu Exon nl Exon ja no Ekson oc Exon pl Ekson pt Ex o ru sl Ekson sr Ekson sv Exon tr Ekson uk zh ... more details
Exon may refer to Exon , a region of DNA that is represented in the mature form of RNA Exoniensis or Exon., the List of post nominal letters The United Kingdom Post Nominal Letters for alumni degrees from the University of Exeter Exon can also refer to the signature of the Bishop of Exeter J. James Exon , the U.S. Senator Exon is a rank for an officer in the Yeomen of the Guard It may also be a spelling error for ExxonMobil , the energy company Exxon , a brand of fuel sold by ExxonMobil disambig ... more details
Unreferenced date December 2009 Orphan date December 2009 Exon trapping is a molecular biology technique to identify potential exons in a fragment of eukaryote DNA of unknown intron exon structure. ref Duyk, G. M, S. W. Kim, R. M Myers, and D. R Cox. 1990. Exon Trapping a Genetic Screen to Identify Candidate Transcribed Sequences in Cloned Mammalian Genomic DNA. Proceedings of the National Academy of Sciences 87 22 8995. ref This is done to determine if the fragment is part of an expressed gene . The genomic fragment is inserted into the intron of a splicing Vector molecular biology vector consisting of a known exon intron exon sequence of DNA. If the fragment does not contain exons i.e., consists solely of intron DNA , it will be spliced out together with the vector s original intron. On the other hand, if exons are contained, they will be part of the mature mRNA after transcription with all intron material removed . The presence of trapped exons can be detected by an increase in size of the mRNA. The technique has largely been supplanted by the approach of DNA sequencing sequencing cDNA generated from mRNA and then using bioinformatics tools such as National Center for Biotechnology Information NCBI s BLAST server to determine the source of the sequence, thereby identifying the appropriate exon intron splice sites. DEFAULTSORT Exon Trapping Category Gene expression References reflist ... more details
Philip of Exon was Archdeacon of Barnstaple until 1279. ref Memorials of Barnstaple being an attempt to supply the want of a history of that ancient borough Gribble,J.B Barnstaple, J.Avery, 1830 ref References Reflist Office holders in the Diocese of Exeter Archdeacons of Barnstaple Persondata Metadata see Wikipedia Persondata . NAME Philip of Exon ALTERNATIVE NAMES SHORT DESCRIPTION Archdeacon of Barnstaple DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Philip of Exon Category Archdeacons of Barnstaple UK reli bio stub Christian clergy stub ... more details
File Exon and Intron classes.png thumb right Intron and exon classes. Introns can be classified into phase ... into 9 groups depending on the phases of their flanking introns. Exon shuffling is a molecular ... different genes can be brought together ectopically, or the same exon can be duplicated, to create a new exon intron structure ref Long, M., Betran, E., Thornton, K., & Wang, W. 2003 . The origin of new ... . There are different mechanisms through which exon shuffling occurs transposon mediated exon shuffling, crossover during sexual recombination of parental genomes and illegitimate recombination. Exon ... the reading frame ref Kolkman, J. A., & Stemmer, W. P. 2001 . Directed evolution of proteins by exon shuffling. Nat Biotechnol, 19 5 , 423 428. doi 10.1038 88084 ref . History Exon shuffling was first .... What is clear now is that the eukaryotic exon intron structure is not static, introns are continually inserted and removed from genes and the evolution of introns evolves parallel to exon shuffling. In order for exon shuffling to start to play a major role in protein evolution the appearance of spliceosomal ... world were unsuitable for exon shuffling by intronic recombination. These introns had an essential ... introns evolved fairly recently and are restricted in their evolutionary distribution. Therefore exon ... precisely the time when exon shuffling became significant in eukaryotes, the evolutionary distribution ... and repetitive sequences. As well as the fact that exon shuffling became significant after metazoan radiation ref Patthy, L. 1999 . Genome evolution and the evolution of exon shuffling a review. Gene, 238 1 , 103 114. doi S0378 1119 99 00228 0 pii ref . Mechanisms of exon shuffling Crossover during ... evolution of proteins by exon shuffling. Nat Biotechnol, 19 5 , 423 428. doi 10.1038 88084 ref . Transposon mediated Long interspersed element LINE 1 File L1 retransposition mechanisms for exon ... is the model for the cis pathway. At the bottom is the trans pathway. A potential mechanism for exon ... more details
Infobox Officeholder name J. James Exon image name Jim exon.jpg jr sr United States Senator state Nebraska ... 6 10 1921 8 9 death place Lincoln, Nebraska Lincoln , Nebraska spouse Patricia Exon religion branch ... Jim Exon August 9, 1921 spaced ndash June 10, 2005 was an United States American United States Democratic .... Exon was a Nebraska Democrat who never lost an election, and the only Democrat to hold his Nebraska ... Exon was born in Geddes, South Dakota , in 1921 and attended the University of Omaha between 1939 and 1941. During World War II, Exon served in the U.S. Army Signal Corps . After the war, he worked as the branch manager of a financial services institution. He founded Exon Office Supplies in Lincoln ... its name to Exxon , it asked Gov. Exon for his permission. He received no financial remuneration ... and 1968 and was a member of the Democratic National Committee from 1968 to 1970. Exon was Chair ... 1979 Exon s first bid for public office was his successful campaign for the Governor of Nebraska ... earned Exon the reputation as a fiscal conservative. He vetoed 141 bills in his final seven years as Governor ... to raise taxes, Exon won the support of many Nebraskans who normally voted Republican. Senator from ... File 1995 p80 J James Exon.jpg thumb 100px right 1995, Congressional Pictorial Directory Exon ... , Exon was a strong defender of the B 2 Spirit B 2 stealth bomber . In 1984, Exon had the closest ... winning re election by 25,000 votes. He was re elected again in 1990. He helped sponsor the Exon ... merger was found to be a threat to National Security. Exon helped to write and secure support for a spending ... History of Senator Exon s Communications Decency Act Regulating Barbarians on the Information ... his retirement, Exon served on a Committee established by Congress and led by John M. Deutch on the threat of weapons of mass destruction. In the report, Exon warned of the dangers if such weapons fell ... he claimed in 2003 that it wasn t highly malignant . Exon died of natural causes in Lincoln, Nebraska ... more details
Tandem exon duplication is defined as duplication of exon s within the same gene to give rise to the subsequent exon. A complete exon analysis of all genes in Homo sapiens , Drosophila melanogaster and Caenorhabditis elegans has shown 12,291 instances of tandem duplication in exons in human , fly and worm . Analysis of the intron ic region has produced further 4,660 unidentified duplicated exons referred to as unannotated exons. 1,578 of these unannotated exons contained stop codon s thus not considered potential exons. 35.1 of the unannotated exons were found in the Expressed sequence tag EST sequence thus confirming the potential of the presence of these exons in protein transcripts. ref cite journal author Letunic I, Copley RR, Bork P title Common exon duplication in animals and its role in alternative splicing journal Hum Mol Genet. volume 11 issue 13 pages 1561 7 year 2002 month Jun pmid 12045209 url http hmg.oxfordjournals.org cgi pmidlookup?view long&pmid 12045209 doi 10.1093 hmg 11.13.1561 ref See also Gene duplication References Reflist Category Molecular evolution Category Molecular genetics Genetics stub ... more details
Multiple issues primary sources August 2011 orphan February 2011 self published August 2011 infobox biodatabase title EID logo File Database.png description database of protein coding intron containing genes. scope organism center Harvard University laboratory Department of Molecular Biology author S Saxonov pmid Saxonov & al. 2000 ref name pmid10592221 released standard format url http mcb.harvard.edu gilbert EID download webservice sql sparql webapp standalone license versioning frequency curation bookmark version the Exon Intron Database EID is a database of Alternative splicing spliced mRNA sequences ref name pmid10592221 cite journal quotes yes last Saxonov first S authorlink coauthors Daizadeh I, Fedorov A, Gilbert W year 2000 month Jan title EID the Exon Intron Database an exhaustive database of protein coding intron containing genes journal Nucleic Acids Res. volume 28 issue 1 pages 185 90 publisher location ENGLAND issn 0305 1048 pmid 10592221 bibcode oclc id url pmc 102483 language eng format accessdate laysummary laysource laydate quote doi 10.1093 nar 28.1.185 ref See also Alternative splicing Exon Intron References references External links http www.utoledo.edu med depts bioinfo database.html Category Biological databases Category Gene expression Category Spliceosome Category RNA splicing Biodatabase stub ... more details
The exon junction complex EJC has major influences on DNA Translation translation , mRNA surveillance surveillance and localization of the RNA splicing spliced mRNA . ref name Tange Tange, T. O. Nott, A., Moore, M. J. Curr. 2004 .Opin. Cell Biol. 16, 279. ref It is first deposited onto mRNA during splicing and is then transported into the cytoplasm . There it plays a major role in post transcriptional regulation of mRNA. It is believed that exon junction complexes provide a position specific memory of the splicing event. The EJC consists of a stable heterotetramer core, which serves as a binding platform for other factors necessary for the mRNA pathway. ref name Tange The core of the EJC contains the protein Eukaryote eukaryotic initiation factor 4AIII eIF4AIII a DEAD box DEAD box RNA helicase bound to an adenosine triphosphate Adenosine triphosphate ATP analog, as well as the additional proteins MAGOH Magoh and Y14 gene Y14 . ref name L L. Ballut et al. 2005 , Nat. Struct. Mol. Biol. 12 ... exon junction complex.gif thumb 400px right 2.3 angstrom resolution structure of a core EJC complex .... ref Aly is believed to be recruited to the exon junction complex by the protein UAP56 . ref Cullen ..., forms a splicing dependent interaction with exon product complexes. J. Cell. Biol.150 309 320. ref .... ref Structure The crystallization of the exon junction complex has revealed the structural organization ... by 67 by 54 . ref name A Andersen, Christian B. F. et al. 2006 . Structure of the Exon Junction ..., M.J. 2002 . 50 exon interactions within the spliceosome establish a framework for exon junction ..., N., and Moore, M.J. 2004 . eIF4AIII binds spliced mRNA in the exon junction complex and is essential ... multiple proteins 20 24 nucleotides upstream of mRNA exonexon junctions. EMBO J. 19, 6860 6869. ref ... NMD EJC in nonsense mediated decay Exon junction complexes play a major role in mRNA surveillance . More ... it reaches the location of the exon junction complex, which it then displaces. Next, translation ... more details
The Exon Florio Amendment http www.law.cornell.edu uscode search display.html?terms 2170&url uscode html uscode50a usc sec 50a 00002170 000 .html 50 U.S.C. app 2170 is a law that was enacted by the United States Congress in 1988 to review foreign investment within the United States. The Amend motion amendment was passed into law under the Omnibus Trade and Competitiveness Act of 1988 and amended Section 721 of Defense Production Act of 1950 . All foreign investments that might affect national security may be reviewed and if deemed to pose a threat to security, the President of the United States , may block the investment. According to the amendment, the president may block the investment when there is credible evidence that leads the President to believe that the foreign interest exercising control might take action that threatens to impair the national security. ref Omnibus Trade and Competitiveness Act of 1988, 5021, Public Law 100 418, US Statutes at Large 102 1988 1107 ref ref Graham, Edward M. David M. Marchick 2006 ref ref 50 U.S.C. Appendix 2170 ref ref implementing regulations at 31 C.F.R. Part 800 ref ref cite book last Graham first Edward M authorlink coauthors David M. Marchick title US National Security and Foreign Direct Investment publisher month May year 2006 location pages url http www.petersoninstitute.org publications chapters preview 3918 02iie3918.pdf format PDF doi id isbn 978 0 88132 391 7 ref Ronald Reagan President Reagan delegated the review process to the Committee on Foreign Investment in the United States . The amendment was sponsored by J. James Exon Senator J. James Exon and James J. Florio Representative James J. Florio . The amendment was proposed over concerns of foreign acquisitions by Japan ese businesses ref cite web url http www.fas.org sgp crs natsec RL33388.pdf title The Committee on Foreign Investment in the United States CFIUS accessdate 2008 06 23 author James K. Jackson last Jackson first James date April 23, 2007 format PDF ... more details
Orphan date September 2008 Trans Spliced Exon Coupled RNA End Determination TEC RED is a technique designed by Muller et al. that, like Serial analysis of gene expression SAGE , allows for the digital detection of messenger RNA sequences. Unlike SAGE, detection and purification of transcripts from the 5 end of the messenger RNA require the presence of a trans spliced leader sequence. Trans splicing Background Spliced leader sequences are short sequences of non coding RNA , not found within a gene itself, that are attached to the 5 end of all, or a portion of, mRNAs transcribed in an organism. They have been found in several species to be responsible for separating polycistronic transcripts into single gene mRNA s, and in others to splice onto monocistronic transcripts. ref name Riddle97 cite book author Riddle, Donald L. title C. elegans II publisher Cold Spring Harbor Laboratory Press location Plainview, N.Y year 1997 isbn 0 87969 532 3 url http www.ncbi.nlm.nih.gov books bv.fcgi?rid ce2 ref The major role of trans splicing on monocistronic transcripts is largely unknown. ref cite journal author Lall S, Friedman CC, Jankowska Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE title Contribution of trans splicing, 5 leader length, cap poly A synergism, and initiation factors to nematode translation in an Ascaris suum embryo cell free system journal J. Biol. Chem. volume 279 issue 44 pages 45573 85 year 2004 month October pmid 15322127 doi 10.1074 jbc.M407475200 url http www.jbc.org cgi content full 279 44 45573 ref It has been proposed that they may act as an independent promoter that aids in tissue specific expression of independent protein isoforms. ref cite journal author Choi J, Newman AP title A two promoter system of gene expression in C. elegans journal Dev. Biol. volume 296 issue 2 pages 537 44 year 2006 month August pmid 16765937 doi 10.1016 j.ydbio.2006.04.470 url http linkinghub.elsevier.com retrieve pii S0012 1606 06 00767 6 ref Spliced leaders have been seen ... more details
Orphan date February 2009 Avimer Proteins are multimeric binding proteins or peptides engineered using in vitro exon shuffling and phage display. Multiple binding domains are linked, resulting in greater affinity and specificity compared to single epitope immunoglobin domains. ref http www.nature.com nbt journal v23 n12 abs nbt1166.html Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains Nature Biotechnology Bot generated title ref These properties make avimer proteins extremely useful as potential tools and therapeutics. References reflist Expert Opinion on Investigational Drugs June 2007, Vol. 16, No. 6, Pages 909 917 Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains Nature Biotechnology 23, 1556 1561 2005 Avimers hold their own Nature Biotechnology 23, 1493 1494 2005 DEFAULTSORT Avimer Proteins Category Peptides ... more details
The Good Life is a state slogan for the state of Nebraska . The Omaha, Nebraska Omaha based advertising firm of J. Greoge Smithson created it in the 70s for J. James Exon Governor J. James Exon . The slogan appears on the roadside billboards that welcome motorists as they enter Nebraska. The state has had a number of other tourism slogans since the 1970s, including Possibilities ... Endless introduced in 2003 , America s Frontier, and Genuine Nebraska. See also List of U.S. state slogans External links http www.nebraska.gov The Official Website for Nebraska http www.visitnebraska.org Official Nebraska Government Website Category Symbols of Nebraska Nebraska stub ... more details
otheruses Exon disambiguation Exoniensis usually abbreviated Exon. is the post nominal letters post nominal suffix given to honorary degree honorary and academic degree s from the University of Exeter . The term is the anglicisation of the Latin for of Exeter . In this way, it is equivalent to Oxon. from the University of Oxford and Cantab. from the University of Cambridge . A graduate of the University of Exeter is called an Exonian, although other institutions also use this term. University of Exeter Category University of Exeter Category Exeter Category Bishops of Exeter Category People associated with the University of Exeter Category Alumni of the University of Exeter ... more details
Infobox Election election name United States Senate election in Nebraska, 1978 country Nebraska type presidential ongoing no previous election United States Senate election in Nebraska, 1972 previous year 1972 next election United States Senate election in Nebraska, 1984 next year 1984 election date November 7, 1984 image1 File Jim exon.jpg 125px nominee1 J. James Exon party1 Democratic Party United States popular vote1 334,096 percentage1 67.7 image2 File Replace this image male.svg 125px nominee2 Donald Eugene Shasteen party2 Republican Party United States popular vote2 159,708 percentage2 32.3 title U.S. Senator before election Carl Curtis before party Republican Party United States after election J. James Exon after party Democratic Party United States ElectionsNE The 1978 United States Senate election in Nebraska was held on November 7, 1978. Incumbent Republican U.S. Senator Carl Curtis decided to retire instead of seeking a fifth term. Democratic nominee J. James Exon won the open seat. Candidates Democratic J. James Exon , Governor of Nebraska Republican Donald Eugene Shasteen Results Election box begin title General election results ref http clerk.house.gov member info electionInfo 1978election.pdf ref Election box winning candidate with party link party Democratic Party United States candidate J. James Exon votes 334,096 percentage 67.66 change 20.82 Election box candidate with party link party Republican Party United States candidate Donald Eugene Shasteen votes 159,708 percentage 32.34 change 20.82 Election box majority votes 174,390 percentage 35.32 change 28.99 Election box turnout votes 493,802 percentage change Election box gain with party link winner Democratic Party US loser Republican Party US swing Election box end References reflist Category United States Senate elections, 1978 Nebraska Category United States Senate elections in Nebraska 1978 Category Nebraska elections, 1978 ... more details
of a regulated alpha tropomyosin exon. RNA 4 85 100. ref The suppression or selection of exons ... exon selection in alpha tropomyosin . ref name Gooding2 Gooding C, Roberts GC, Moreau G, Nadal Ginard B, Smith CW. 1994 . Smooth muscle specific switching of alpha tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J 13 16 3861 72. ref References references ... more details
Unreferenced date December 2009 A class II gene is a type of gene that codes for a protein . Class II genes are transcription genetics transcribed by RNAP RNAP II . Class II genes have a promoter biology promoter that often contains a TATA box . Basal transcription of class II genes requires the formation of a preinitiation complex . They are transcribed by RNA polymerase II, include both intron and exon, and code for polypeptide. DEFAULTSORT Class Ii Gene Category Genes Category Molecular biology Genetics stub Biochem stub ... more details
EJC may refer to European Jewish Congress , a representative body of European Jewish communities Eglise de J sus Christ , an independent Christian church in Congo Electronic Journal of Combinatorics , a peer reviewed academic journal specializing in combinatorics European Juggling Convention , an annual juggling festival European Junior Championships in various sports European Judo Championships , an annual event Exon junction complex , formed on mRNA after splicing disambig de EJC fr EJC ... more details
Infobox school name Remuera Intermediate School motto Reliability, Integrity, Service established 1954 principal Janet Exon address Ascot Avenue, br Remuera, br Auckland coordinates Coord 36.8859 174.7999 type edu region NZ AUK display inline,title type State coed intermediate, years 7 8 roll 1000 decile 9 MOE 1461 homepage http www.remint.school.nz remint.school.nz Remuera Intermediate School is a school catering for 10 to 13 year olds in Remuera , Auckland , New Zealand . The school was founded in 1954. The current Principal of the school is Janet Exon, and the deputy principal of the school is Matthew Crumpton. The school s roll consists of around 900 students, varying slightly from year to year. Related links http www.remint.school.nz Remuera Intermediate School http www.tki.org.nz e schools display school info.php?school id 1461 Te Kete Ipurangi School Profile Category Educational institutions established in 1954 Category Intermediate schools in New Zealand Category Schools in Auckland NZ school stub ... more details
An exonic splicing enhancer ESE is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing genetics splicing of hetero nuclear RNA hnRNA or pre mRNA into messenger RNA mRNA . The Basics The central dogma of molecular biology states that all of the information that makes you unique is housed in the cell nucleus nucleus of every cell biology cell in your body in the form of DNA . The human DNA is a string of 3.2 billion base pairs . Short sequences of DNA are transcribed to RNA then this RNA is translated to a protein . A gene located in the DNA will contain introns and exons . Part of the process of preparing the RNA includes splicing genetics splicing out the introns, sections of RNA that do not code for protein. The presence of exonic splicing enhancers is essential for proper identification of splice sites by the cellular machinery. Research Computational methods were used to identify 238 candidate ESEs. ESEs are clinically significant because synonymous point mutations previously thought to be silent mutations located in an ESEs can lead to exon skipping and the production of a non functioning protein. Disruption of an exon splicing ehancer in exon 3 of MLH1 gene is the cause of HNPCC hereditary non polyposis colorectal cancer in a Quebec family. ref cite journal author McVety S, Li L, Gordon PH, Chong G, Foulkes WD title Disruption of an exon splicing enhancer in exon 3 of MLH1 is the cause of HNPCC in a Quebec family journal J. Med. Genet. volume 43 issue 2 pages 153 6 year 2006 month February pmid 15923275 pmc 2564635 doi 10.1136 jmg.2005.031997 url http jmg.bmj.com cgi pmidlookup?view long&pmid ref There is evidence that these 236 hexamers that signal splicing are evolutionarily conserved. ref cite journal author Carlini DB, Genut JE title Synonymous SNPs provide evidence for selective constraint on human exonic splicing enhancers journal J. Mol. Evol. volume 62 issue 1 pages 89 98 year 2006 month January pmid 16320116 ... more details
Infobox Election election name United States Senate election in Nebraska, 1990 country Nebraska type presidential ongoing no previous election United States Senate election in Nebraska, 1984 previous year 1984 next election United States Senate election in Nebraska, 1996 next year 1996 election date November 5, 1990 image1 File Jim exon.jpg 125px nominee1 J. James Exon party1 Democratic Party United States popular vote1 349,779 percentage1 58.9 image2 File Daub.jpg 100px nominee2 Hal Daub party2 Republican Party United States popular vote2 243,013 percentage2 40.9 map image map size 200px map caption County results title U.S. Senator before election J. James Exon before party Democratic Party United States after election J. James Exon after party Democratic Party United States ElectionsNE The 1990 United States Senate election in Nebraska was held on November 5, 1990. Incumbent Democratic U.S. Senator J. James Exon won re election to a third term. Candidates Democratic J. James Exon , incumbent U.S. Senator Republican Hal Daub , U.S. Congressman Results Election box begin title General election results ref http clerk.house.gov member info electionInfo 1990election.pdf General Election Results, House ref Election box winning candidate with party link party Democratic Party United States candidate J. James Exon incumbent inc. votes 379,933 percentage 58.90 change 6.97 Election box candidate with party link party Republican Party United States candidate Hal Daub votes 243,013 percentage 40.92 change 7.09 Election box candidate party Write ins candidate votes 1,036 percentage 0.17 change Election box majority votes 106,766 percentage 17.98 change 14.06 Election box turnout votes 593,828 percentage change Election box hold with party link winner Democratic Party US loser swing Election box end References reflist United States elections, 1990 Category United States Senate elections, 1990 Nebraska Category United States Senate elections in Nebraska 1990 Category Nebraska e ... more details
Infobox Election election name United States Senate election in Nebraska, 1984 country Nebraska type presidential ongoing no previous election United States Senate election in Nebraska, 1978 previous year 1978 next election United States Senate election in Nebraska, 1990 next year 1990 election date November 6, 1984 image1 File Jim exon.jpg 125px nominee1 J. James Exon party1 Democratic Party United States popular vote1 332,117 percentage1 51.9 image2 File Replace this image female.svg 125px nominee2 Nancy Hoch party2 Republican Party United States popular vote2 307,147 percentage2 48.0 title U.S. Senator before election J. James Exon before party Democratic Party United States after election J. James Exon after party Democratic Party United States ElectionsNE The 1984 United States Senate election in Nebraska was held on November 6, 1984. Incumbent Democratic U.S. Senator J. James Exon won re election to a second term. Candidates Democratic J. James Exon , incumbent U.S. Senator Republican Nancy Hoch, businesswoman Results Election box begin title General election results ref http clerk.house.gov member info electionInfo 1984election.pdf ref Election box winning candidate with party link party Democratic Party United States candidate J. James Exon incumbent inc. votes 332,217 percentage 51.94 change 15.72 Election box candidate with party link party Republican Party United States candidate Nancy Hoch votes 307,147 percentage 48.02 change 15.67 Election box candidate party Write ins candidate votes 304 percentage 0.05 change Election box majority votes 25,070 percentage 3.92 change 31.40 Election box turnout votes 639,668 percentage change Election box hold with party link winner Democratic Party US loser swing Election box end References reflist United States elections, 1984 Category United States Senate elections, 1984 Nebraska Category United States Senate elections in Nebraska 1984 Category Nebraska elections, 1984 ... more details
protein Name major histocompatibility complex, class II, DP alpha 1 caption image width HGNCid 4938 Symbol HLA DPA1 AltSymbols HLA DP1A EntrezGene 3113 OMIM 142880 RefSeq NM 033554 UniProt P20036 PDB ECnumber Chromosome 6 Arm p Band 21.3 LocusSupplementaryData Major histocompatibility complex, class II, DP alpha 1 , also known as HLA DPA1 , is a human gene . ref name Entrez Gene 3113 cite web title Entrez Gene HLA DPA1 major histocompatibility complex, class II, DP alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3113 accessdate ref Function The protein encoded by this gene belongs to the MHC class II HLA class II alpha chain Homology 28biology 29 Paralogy paralogues . The class II molecule is a heterodimer consisting of an alpha DPA and a beta chain DPB , both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cell s APC B lymphocytes, dendritic cells, macrophages . ref name Entrez Gene 3113 Gene structure and polymorphisms The alpha chain is approximately 33 35 kDa. It is encoded by 5 exon s, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domain domains , exon 4 encodes the transmembrane protein transmembrane and the cytoplasm cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphism biology polymorphism s specifying the peptide binding specificities, resulting in up to 4 different molecules. ref name Entrez Gene 3113 See also Major histocompatibility complex Human leukocyte antigen HLA DP References reflist Surface antigens gene 6 stub NLM content ... more details
Infobox protein family Symbol Btz Name Btz image PDB 2hyi EBI.jpg width caption structure of the human exon junction complex with a trapped dead box helicase bound to rna Pfam PF09405 Pfam clan InterPro IPR018545 SMART PROSITE MEROPS SCOP TCDB OPM family OPM protein CAZy CDD In molecular biology, the Btz domain CASC3 Barentsz eIF4AIII binding domain is a protein domain found on CASC3 cancer susceptibility candidate gene 3 protein which is also known as Barentsz Btz . CASC3 is a component of the EJC exon junction complex which is a Protein complex complex that is involved in Post transcriptional regulation post transcriptional regulation of mRNA in metazoa . The complex is formed by the association of four protein s EIF4A3 eIF4AIII , Barentsz, MAGOH Mago , and RBM8A Y14 , mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the Directionality molecular biology 5 nucleotide . ref name pmid16923391 cite journal author Bono F, Ebert J, Lorentzen E, Conti E title The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA journal Cell volume 126 issue 4 pages 713 25 year 2006 month August pmid 16923391 doi 10.1016 j.cell.2006.08.006 url ref ref name pmid14973490 cite journal author Palacios IM, Gatfield D, St Johnston D, Izaurralde E title An eIF4AIII containing complex required for mRNA localization and nonsense mediated mRNA decay journal Nature volume 427 issue 6976 pages 753 7 year 2004 month February pmid 14973490 doi 10.1038 nature02351 url ref References reflist InterPro content IPR018545 Category Protein domains ... more details
Infobox company company name Prosensa Therapeutics company type Privately held company Private company foundation 2002 location Leiden , Netherlands key people Hans Schikan small Chief Executive Officer CEO small , Giles Champion small Chief Medical Officer small , Daan Ellens small Chairman small industry Biotechnology products Drug Pharmaceuticals num employees 85 ref http prosensa.eu about prosensa company profile Prosensa official website ref intl yes homepage http www.prosensa.eu www.prosensa.eu Prosensa Therapeutics is a Netherlands Dutch biopharmaceutical company developing therapies for rare diseases, particularly neuromuscular disorders. Prosensa focuses on RNA based therapies that utilise exon skipping to rescue protein production in diseases in which protein production is disrupted by DNA mutations . The company aims to treat diseases such as Duchenne muscular dystrophy DMD , myotonic dystrophy and Huntington s disease . Partnerships In September 2009, Prosensa and GlaxoSmithKline announced a collaboration on the development and commercialisation of an exon skipping compound, PRO051 , for the treatment of DMD. The product is currently in Phase III clinical trials ref http clinicaltrials.gov ct2 show NCT01480245 Record NCT01480245 from clinicaltrials.gov ref . In September 2011, the two companies extended their collaboration on preclinical and clinical development of three more exon skipping compounds for the treatment of DMD ref http www.thepharmaletter.com file 107377 prosensa to get milestone payments from gsk under duchenne collaboration.html Prosensa to get milestone payments from GSK under Duchenne collaboration The Pharma Letter ref . External links Official website http www.prosensa.eu References reflist Category Biotechnology companies ... more details
Encyclopedia
top
