Experimentalautoimmuneencephalomyelitis , sometimes Experimental Allergic Encephalomyelitis EAE is an animal model of brain inflammation . It is an inflammatory demyelinating disease of the central nervous system CNS . It is mostly used with rodent s and is widely studied as an animal model of the human CNS demyelinating diseases, including the disease s multiple sclerosis and acute disseminated encephalomyelitis ADEM . EAE is also the prototype for T cell mediated autoimmune disease in general. EAE was motivated by observations during the convalescence from virus viral diseases by Thomas M. Rivers, D. H. Sprunt and G. P. Berry in 1933. Their findings upon a transfer of inflamed patient tissue to primate s was published in the Journal of Experimental Medicine article Vol. 58, No. 1, pp. ... ENCEPHALOMYELITIS IN MONKEYS. Journal of Experimental Medicine 58 39 53. ref ref Rivers TM & Schwentker FF. 1935 . Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. Journal of Experimental Medicine 61 689 701. ref . An acute monophasic illness, it has been suggested that EAE is far more similar to ADEM than MS ref Sriram S & Steiner I 2005 Experimental Allergic Encephalomyelitis A misleading model of Multiple Sclerosis. Annals of Neurology 58 939 945 ... and pathology ref MANNIE, M., R. H. SWANBORG and J. A. STEPANIAK, 2009 Experimentalautoimmuneencephalomyelitis in the rat. Curr Protoc Immunol Chapter 15 Unit 15 12 ref ref MILLER, S. D., and W. J. KARPUS, 2007 Experimentalautoimmuneencephalomyelitis in the mouse. Curr Protoc Immunol Chapter ... up to 3 bouts of disease within an experimental period. EAE in mice Demyelination is produced by injection ... Research Unit, The University of Queensland Multiple sclerosis DEFAULTSORT ExperimentalAutoimmuneEncephalomyelitis Category Demyelinating diseases of CNS Category Animal testing cs Experiment ln autoimunitn encefalomyelitida de Experimentelle autoimmune Enzephalomyelitis el ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 G 04 g 00 ICD10 G 05 g 00 ICD9 ICD9 323 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D004679 Encephalomyelitis is a general term for inflammation of the brain and spinal cord , describing a number of disorders Acute disseminated encephalomyelitis or postinfectious encephalomyelitis , a demyelinating disease of the brain and spinal cord, possibly triggered by vaccination or virus viral infection ref RareDiseases 8639 Acute disseminated encephalomyelitis ref ref NINDS acute encephalomyelitis Acute Disseminated Encephalomyelitis Information Page ref Encephalomyelitis disseminata , a synonym for multiple sclerosis Equine encephalomyelitis , a potentially fatal mosquito borne viral disease that infects horses and humans Myalgic encephalomyelitis , a syndrome involving inflammation of the central nervous system with symptoms of muscle pain and fatigue the term has sometimes been used interchangeably with chronic fatigue syndrome , though there is still controversy over the distinction. ref RareDiseases 7121 Myalgic encephalomyelitis ref Experimental autoimmune encephalomyelitis EAE , an animal model of brain inflammation. References reflist disease stub Diseases of the nervous system Category Neurological disorders bg cs Encefalomyelitida it Encefalomielite ... more details
Viliuisk Encephalomyelitis VE is a fatal progressive neurological disorder found only in the Yakuts Sakha Iakut Yakuts Yakut population of central Siberia . ref name S1 cite journal last1 Goldfarb first1 L.G. last2 Gajdusek first2 D.C. year 1992 title Viliuisk Encephalomyelitis in the Iakut people of Siberia url journal Brain volume 115 issue page 961 pmid 1393513 ref ref name S2 cite journal last1 Oleksyk first1 TK last2 Goldfarb first2 LG last3 Sivtseva first3 T last4 Danilova first4 AP last5 Osakovsky first5 VL last6 Shrestha first6 S last7 O Brien first7 SJ last8 Smith first8 MW title Evaluating association and transmission of eight inflammatory genes with Viliuisk encephalomyelitis susceptibility. journal European Journal of Immunogenetics volume 31 issue 3 pages 121 8 year 2004 pmid 15182325 doi 10.1111 j.1365 2370.2004.00459.x ref About 15 new cases are reported each year. VE is a very rare disease and little research has been conducted. The causative agents, origin of the disease, and involved candidate genes are currently unknown, but much research has been done in pursuit of the answers. Those inflicted with the disease survive for a period of only a few months to several years. VE follows three main courses of infection an Acute medical acute form, a sub acute form subsiding ... doi 10.1126 science.296.5568.642 ref Viliuisk Encephalomyelitis is classified as a progressive ... first7 AI last8 Alekseev first8 VP last9 Gajdusek first9 DC title Viliuisk encephalomyelitis ... last4 Brown first4 B.D. year 1999 title natural experimental models the global search for biomedical ... conducted. ref name S5 Gajdusek DC, Goldfarb LG. Bibliography of Viliuisk Encephalomyelitis in the Iakut ... S8 World Health Organization . Program for Investigation of Viliuisk Encephalomyelitis in Collaboration ... neurology rigidity of the limbs those infected individuals experienced. Viliuisk Encephalomyelitis ... Encephalomyelitis in the Iakut People of Siberia http www.sciencemag.org cgi content full 296 ... more details
T cells Indirect evidence based on reproduction of the autoimmune disease in experimental animals Circumstantial evidence from clinical clues Classification It is possible to classify autoimmune ...expert subject 1 Medicine date November 2011 Infobox disease Name Autoimmune diseases Image Caption DiseasesDB ... eMedicineTopic MeshID D001327 Autoimmune diseases arise from an inappropriate immune response ... to certain organ anatomy organ s e.g. in autoimmune thyroiditis or involve a particular tissue in different ... and the kidney . The treatment of autoimmune diseases is typically with immunosuppression &mdash medication which decreases the immune response. Criteria For a disease to be regarded as an autoimmune ... author Rose NR, Bona C title Defining criteria for autoimmune diseases Witebsky s postulates revisited ... type III , or Type IV hypersensitivity type IV . No type of autoimmune disease mimics type ... ref There is an on going discussion about when a disease should be considered autoimmune, leading ... Accepted br suspected Hypersensitivity I, II, III, IV Autoantibody Notes Acute disseminated encephalomyelitis ADEM Accepted ref name Mesh MeshName Autoimmune Diseases ref Addison s disease interferon ... I Autoimmune aplastic anemia Autoimmune cardiomyopathy Accepted Autoimmune enteropathy Autoimmune hemolytic anemia Accepted II complement activation Autoimmune hepatitis Accepted cell mediated ... liver antigen Autoimmune inner ear disease Accepted ref name urlAutoimmune Inner Ear Disease cite web url http www.bcm.edu oto grand 4893.html title Autoimmune Inner Ear Disease, Baylor College of Medicine year 1993 ref Autoimmune lymphoproliferative syndrome Accepted TNFRSF6 defective Fas CD95 apoptosis Autoimmune peripheral neuropathy Accepted Autoimmune pancreatitis Accepted Anti nuclear antibody ANA anti lactoferrin antibodies anti carbonic anhydrase antibodies rheumatoid factor Autoimmune polyendocrine syndrome Accepted Unknown or multiple APS 1 see Addison s disease Autoimmune progesterone ... more details
Infobox disease Name Autoimmune hepatitis Image Autoimmune hepatitis cropped very high mag.jpg Caption ... of autoimmune hepatitis. Liver biopsy . H&E stain . DiseasesDB 1150 ICD10 ICD10 K 75 4 k 70 ICD9 ICD9 571.42 ICDO OMIM MedlinePlus 000245 eMedicineSubj med eMedicineTopic 366 MeshID D019693 Autoimmune ... liver infection , causes a cell mediated immune response against the body s own liver, resulting in autoimmune ... lead to further complications, including cirrhosis . ref name urlDigestive Disease Autoimmune Hepatitis ... Autoimmune Hepatitis author National Digestive Diseases Information Clearinghouse accessdate October 9, 2010 , ref Autoimmune hepatitis has an incidence of 1 2 per 100,000 per year, and a prevalence of 10 20 100,000. As with most other autoimmune disease s, it affects women much more often than men ... title Autoimmune Hepatitis work accessdate ref Liver enzyme s are elevated, as may be bilirubin . Classification ... IR, Vergani D title Autoimmune liver serology Current diagnostic and clinical challenges journal ... ref name urlautoimmune hepatitis cite web url http www.meddean.luc.edu Lumen MedEd orfpath autoimmune 20hepatitis.htm title autoimmune hepatitis work accessdate ref this group behaves like group 1 ref ... diagnosis of autoimmune hepatitis is best achieved with a combination of clinical trial clinical , laboratory ... are of use, as is finding an increased IgG Immunoglobulin G level. However, the diagnosis of autoimmune ... to help determine if a patient has autoimmune hepatitis, which combines clinical and laboratory features ... al. title International Autoimmune Hepatitis Group Report review of criteria for diagnosis of autoimmune ... sholland contrivances aihcalc.html title Autoimmune Hepatitis Calculator work accessdate 2008 ... has been observed. ref name pmid17486048 cite journal author Washington MK title Autoimmune liver ... Autoimmune hepatitis classification, heterogeneity, and treatment journal Am. J. Med. volume 96 ... ref References reflist 2 Gastroenterology Hypersensitivity and autoimmune diseases DEFAULTSORT ... more details
, methanol poisoning, and other underlying conditions. Experimental allergic encephalomyelitis main ExperimentalautoimmuneencephalomyelitisExperimental allergic encephalomyelitis EAE is an animal model ...Infobox disease Name Acute disseminated encephalomyelitis Image Caption DiseasesDB 158 ICD10 ICD10 G ... MeshID D004673 Acute disseminated encephalomyelitis ADEM is an immune mediated disease of the human brain brain . ref cite journal author Dale RC title Acute disseminated encephalomyelitis journal Semin ... spid.2003.127225 url ref ref cite journal author Garg RK title Acute disseminated encephalomyelitis ... journal author Jones CT title Childhood autoimmune neurologic diseases of the central nervous system .... As it involves autoimmune demyelinating disease demyelination , it is similar to multiple ... RS title Multiple sclerosis, acute disseminated encephalomyelitis, and related conditions journal ... encephalomyelitis and multiple sclerosis two different diseases a critical review journal Acta ... encephalomyelitis in childhood epidemiologic, clinical and laboratory features journal Pediatr ... encephalomyelitis in children journal Neurology volume 56 issue 10 pages 1308 12 year 2001 month ... al. title Acute disseminated encephalomyelitis in children outcome and prognosis journal Neuropediatrics ... disseminated encephalomyelitis a follow up study of 40 adult patients journal Neurology volume 56 ... disseminated encephalomyelitis an acute hit against the brain journal Curr. Opin. Neurol. volume ... encephalomyelitis journal Curr Neurol Neurosci Rep volume 3 issue 3 pages 256 64 year 2003 ... suffers more than one demyelinating episode, it is called Recurrent disseminated encephalomyelitis ref cite journal author Poser CM title Multiple sclerosis and recurrent disseminated encephalomyelitis ... encephalomyelitis ref name Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG 2000 2407 ... encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children ... more details
Orphan date February 2009 Infobox Disease Name Autoimmune neutropenia Image Caption DiseasesDB 32421 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj ped eMedicineTopic 184 MeshID Autoimmune neutropenia is a form of neutropenia which is most common in infants and young children ref name pmid9414283 cite journal author Bux J, Behrens G, Jaeger G, Welte K title Diagnosis and clinical course of autoimmune neutropenia in infancy analysis of 240 cases journal Blood volume 91 issue 1 pages 181 6 year 1998 pmid 9414283 doi url http www.bloodjournal.org cgi pmidlookup?view long&pmid 9414283 ref where the body identifies the neutrophils as enemies and makes antibodies antibody to destroy them. Primary autoimmune neutropenia AIN is an autoimmune disorder first reported in 1975 that primarily occurs in infancy. In autoimmune neutropenia, the immune system produces autoantibodies directed against the neutrophilic protein antigens in white blood cells known as granulocytic neutrophils granulocytes, segmented neutrophils, segs, polysegmented neutrophils, polys . These antibodies destroy granulocytic neutrophils. Consequently, patients with autoimmune neutropenia have low levels of granulocytic neutrophilic white blood cells causing a condition of neutropenia. Neutropenia causes an increased risk of infection from organisms that the body could normally fight easily. Who is Affected? Primary autoimmune ... conditions occur, including other autoimmune diseases, infections, and malignancies. Neutropenia ... is severe. Ear infections otitis media are the most common infection seen in autoimmune neutropenia .... Studies of children studied for up to six years showed that most cases of autoimmune neutropenia ... for 7 to 24 months. Diagnosis Patients with autoimmune neutropenia are diagnosed on the basis of blood ... Bruin M, Dassen A, Pajkrt D, Buddelmeyer L, Kuijpers T, de Haas M title Primary autoimmune neutropenia ... References reflist DEFAULTSORT Autoimmune Neutropenia Category Monocyte and granulocyte disorders ... more details
eMedicineSubj eMedicineTopic MeshID D013967 Autoimmune thyroiditis, or Chronic Autoimmune thyroiditis ... H. Daniels. title Chronic Autoimmune Thyroiditis journal The New England Journal of Medicine year 1996 volume 335.2 pages 99 107 ref Specialists clinically separate autoimmune thyroiditis into two ... H. Daniels. title Chronic Autoimmune Thyroiditis journal The New England Journal of Medicine year 1996 ... first Dayan, Colin M coauthors Dayan, Colin M., and Gilbert H. Daniels. title Chronic Autoimmune Thyroiditis ... last Dayan first Dayan, Colin M coauthors Dayan, Colin M., and Gilbert H. Daniels. title Chronic Autoimmune ... H. Daniels. title Chronic Autoimmune Thyroiditis journal The New England Journal of Medicine ... H. Daniels. title Chronic Autoimmune Thyroiditis journal The New England Journal of Medicine ... with time. ref name ref2 Causes The exact cause for autoimmune thyroiditis is not known for certain ..., Colin M coauthors Dayan, Colin M., and Gilbert H. Daniels. title Chronic Autoimmune Thyroiditis ... degree relatives of patients with some type of autoimmune thyroiditis present thyroid antibodies ... M., and Gilbert H. Daniels. title Chronic Autoimmune Thyroiditis journal The New England Journal of Medicine ... of autoimmune thyroiditis up to fifty percent . ref name ref 1 cite journal last Dayan first Dayan, Colin M coauthors Dayan, Colin M., and Gilbert H. Daniels. title Chronic Autoimmune Thyroiditis ... Autoimmune thyroiditis has a higher prevalence in societies that have a higher intake of iodine ... H. Daniels. title Chronic Autoimmune Thyroiditis journal The New England Journal of Medicine year ... Dayan first Dayan, Colin M coauthors Dayan, Colin M., and Gilbert H. Daniels. title Chronic Autoimmune ... Autoimmune Thyroiditis journal The New England Journal of Medicine year 1996 volume 335.2 pages 99 .... Autoimmune thyroiditis can also affect children. Although it is very rare for children ... autoimmune thyroiditis. ref name ref 1 cite journal last Dayan first Dayan, Colin M coauthors ... more details
about the Meat Beat Manifesto album autoimmune Infobox album See Wikipedia WikiProject Albums Name Autoimmune Type studio Artist Meat Beat Manifesto Cover Autoimmune MBM 2008.jpg Released 2008 April 08 Recorded Room 5 Genre Dubstep Length US version 1 05 45 br UK version 50 27 Label Metropolis Records small MET531 small br Planet Mu small ZIQ202 small Producer Jack Dangers Last album At the Center 2005 This album Autoimmune 2008 Next album Answers Come in Dreams 2010 Album ratings rev1 Allmusic rev1score Rating 4.5 5 ref Allmusic class album id r1340586 pure url yes Allmusic review ref rev2 PopMatters rev2score Rating 6 10 ref http www.popmatters.com pm review 56200 meat beat manifesto autoimmune PopMatters review ref Automatically generated by DASHBot Autoimmune is an album by Meat Beat Manifesto . Originally announced as a twenty track 2xCD release, ref cite web title MBM News page at Brainwashed url http brainwashed.com mbm date 21 May 2007 accessdate 2009 04 05 ref Dangers decided to shorten the album down ref name igloomag cite web url http igloomag.com profiles 1693 MEAT BEAT MANIFESTO Its all about the rhythm title MEAT BEAT MANIFESTO It s all about the rhythm publisher Igloo Magazine date 1 April 2008 accessdate 2010 02 07 ref to a single disc with different track listings between the US and European releases ref cite web title Autoimmune url http brainwashed.com common htdocs discog met531.php?site mbm07 accessdate 2008 04 02 ref . Stylistically, it steps up the pace a bit from other recent MBM albums, flirting with elements of dub, hip hop, industrial, breakbeat and more ... news 2008 04 meat beat title Autoimmune review Jack Dangers interview publisher Wired date 7 April ... released on an EP available only on the Autoimmune tour ref cite web url http brainwashed.com common ... These tracks appeared on an exclusive tour EP after the release of Autoimmune and would have originally ... DEFAULTSORT Autoimmune Album Category Meat Beat Manifesto albums Category 2008 albums ... more details
Infobox disease Name Autoimmune hypophysitis Image Caption DiseasesDB 34426 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Autoimmune hypophysitis or Lymphocytic hypophysitis is defined as Hypopituitarism below normal production of one or more hormones by the pituitary gland due to autoimmunity . Signs and symptoms The symptoms depend on what part of the pituitary is affected. Lymphocytic adenohypophysitis LAH is when the anterior pituitary ACTH producing cells are affected resulting in adrenal insufficiency . Lymphocytic Infundibuloneurohypophysitis LINH is when the posterior pituitary is affected resulting in diabetes insipidus and symptoms of an intracranial mass. Lymphocytic Infudibulopanhypophysitis LIPH is involvement of both the posterior pituitary and anterior pituitary involvement resulting in both diabestes insipidus and adrenal insufficiency. ref cite journal ... to 40 years for autoimmune destruction to present symptoms. ref name pmid9691980 cite journal author ..., Autoimmune Diseases, Cytotoxic Antigen Induces Hypophysitis in Cancer Patients, 2006 1 9 br see also ..., 20 of autoimmune thyroid patients also have pituitary antibodies. ref name pmid17554056 It follows that a subset of thyroid patients may have a disease related to autoimmune hypophysitis. Recent ... as much as 5 of the population experiences some amount of autoimmune pituitary destruction. It is further .... History Autoimmune disease Autoimmune attack of the pituitary gland resulting in reduced hormone ... of the pituitary and thyroid consistent with autoimmune attack and included atrophy of the adrenal ... R., and Mack, Ian R., The Autoimmune diseases, chap. 40, at pg. 548. ref As Magnetic Resonance Imaging ... author Caturegli, P., title Autoimmune hypophysitis an underestimated disease in search of its autoantigen ... Nevertheless, autoimmune hypophysitis is frequently referred to as a rare disease and estimates as to its ... and autoimmune diseases Category Pituitary disorders Category Autoimmune diseases ... more details
PBB geneid 326 The autoimmune regulator AIRE is a protein that in humans is encoded by the AIRE gene . ref name pmid9398840 cite journal author title An autoimmune disease, APECED, caused by mutations ..., T cells can attack the body, resulting in autoimmune disease . Function In the thymus, the autoimmune ... an autoimmune reaction. So the expression of non local proteins by AIRE reduces the threat of the occurrence ... to become central tolerance tolerant towards peripheral organs, thereby suppressing autoimmune disease ... ref Pathology The autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 APECED Type 1 APS 1 , also known as Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy APECED . Disruption of AIRE results in the development of a range of autoimmune ... doi 10.1093 hmg 11.4.397 ref Interactions Autoimmune regulator has been shown to Protein protein ... M, Scott HS, Antonarakis SE, Kudoh J, Shimizu N, Krohn K, Peterson P title The autoimmune regulator ... N, Antonarakis SE, Scott HS, Krohn K title APECED mutations in the autoimmune regulator AIRE gene ... K, Yamada E, Kanaji Y, Takano K title A novel missense mutation of AIRE gene in a patient with autoimmune ... Ruan QG, She JX title Autoimmune polyglandular syndrome type 1 and the autoimmune regulator journal ... L title An autosomal locus causing autoimmune disease autoimmune polyglandular disease type I assigned ... of the autoimmune polyendocrinopathy candidiasis ectodermal dystrophy locus on chromosome 21q22.3 ... Common mutations in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy patients of different ... Mutations in the AIRE gene effects on subcellular location and transactivation function of the autoimmune ... P, Ollila J, Vihinen M, Scott HS, Antonarakis SE, Kudoh J, Shimizu N, Krohn K, Peterson P title The autoimmune ... P, Krohn K, Peterson P title Subcellular localization of the autoimmune regulator protein. characterization ... mutation in the autoimmune regulator AIRE 1 gene in a French family with autoimmune polyendocrinopathy ... more details
Refimprove date November 2009 Autoimmune pancreatitis AIP is an increasingly recognized type of chronic pancreatitis that can be difficult to distinguish from pancreatic carcinoma but which responds to treatment with corticosteroids , particularly prednisone . ref cite book title The autoimmune diseases publisher Academic Press first1 Noel R. last1 Rose first2 Ian R. last2 Mackay edition 4 year 2006 ISBN 0125959613 pages 783 ref It is increasingly regarded as a form of hyper IgG4 disease . Clinical features AIP is characterized by the following features 1 mild symptoms abdominal pain, weight loss, nausea , usually without acute attacks of pancreatitis, 2 increased serum levels of gamma globulins, immunoglobulin G IgG , or IgG4, 3 the presence of serum autoantibodies such as anti nuclear antibody ANA , anti lactoferrin antibody, anti carbonic anhydrase II antibody, and rheumatoid factor RF , 4 a diffusely enlarged pancreas, 5 diffuse irregular narrowing of the main pancreatic duct and stenosis of the intrapancreatic bile duct on endoscopic retrograde cholangiopancreatography ERCP , 6 rare pancreatic calcification or cyst formation, and 7 marked responsiveness to treatment with corticosteroids. AIP is sometimes associated with other autoimmune disorders, most commonly Sj gren s syndrome , primary sclerosing cholangitis PSC , and inflammatory bowel disease . AIP occurring in association with an autoimmune disorder has been referred to as secondary or syndromic AIP. Diagnostic criteria In 2002, the Japanese Pancreas Society proposed the following diagnostic criteria for autoimmune pancreatitis I. Pancreatic imaging studies show diffuse narrowing of the main pancreatic duct with irregular wall more than 1 3 of length of the entire pancreas . II. Laboratory data demonstrate abnormally .... Terms frequently encountered are autoimmune or autoimmune related pancreatitis, lymphoplasmacytic ... Autoimmune diseases ja fi Autoimmuunipankreatiitti ... more details
Theiler s Murine Encephalomyelitis Virus TMEV is a single stranded RNA murine cardiovirus from the family Picornaviridae that has been used as a mouse model for studying virally induced paralysis as well as encephalomyelitis comparable to Multiple sclerosis . ref cite journal last1 Stavrou first1 S last2 Feng first2 Z last3 Lemon first3 SM last4 Roos first4 RP title Different strains of Theiler s murine encephalomyelitis virus antagonize different sites in the type I interferon pathway journal Journal of Virology volume 84 issue 18 pages 9181 9 year 2010 pmid 20610716 pmc 2937600 doi 10.1128 JVI.00603 10 ref Depending on the mouse and viral strain , viral pathogenesis can range from negligible, to chronic or acute encephalomyelitis. Discovery The virus was discovered by Nobel Prize winning virologist Max Theiler in 1937 while working at the Rockefeller University Rockefeller Institute . ref http nobelprize.org nobel prizes medicine laureates 1951 theiler bio.html ref ref cite journal doi 10.1084 jem.65.5.705 last1 Theiler first1 M title Spontaneous Encephalomyelitis of Mice, A New Virus Disease journal The Journal of experimental medicine volume 65 issue 5 pages 705 19 year 1937 pmid 19870629 pmc 2133518 ref Known mostly for his work with Yellow Fever , Theiler s encephalomyelitis virus was discovered during research on poliovirus like symptoms in mice. Strains There are several different strains of TMEV that are characterized by their pathology as well as genetic sequencing dn date December 2011 and proteomics . The two major groups are listed below, but there are several other ... encephalomyelitis in susceptible mice, with a high mortality rate and no viral persistence after viral ... Y. last2 Obuchi first2 M. chapter Theiler s murine encephalomyelitis virus TMEV Molecular aspects ... Kunihiko last4 Okuwa first4 Takako title Leader L and L proteins of Theiler s murine encephalomyelitis ... between the study of mouse TMEV induced encephalomyelitis and human Multiple Sclerosis. ref cite journal ... more details
Infobox Disease Name CNS demyelinating autoimmune diseases Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D020278 CNS demyelinating autoimmune diseases are autoimmune disease s which primarily affect the central nervous system . Examples include Diffuse cerebral sclerosis of Schilder Acute disseminated encephalomyelitis Acute hemorrhagic leukoencephalitis Multiple sclerosis though ethiology is unknown, it is sure that immune system is involved Transverse myelitis Neuromyelitis optica See also Idiopathic inflammatory demyelinating diseases A wider group of diseases which includes also the non autoimmune demyelinating diseases. Demyelinating disease s Group including them all, regardless of their autoimmunity or idiopathic and inflammatory status. CNS diseases of the nervous system disease stub Category Autoimmune diseases Category Demyelinating diseases of CNS ... more details
Avian encephalomyelitis virus , or AEV , also known epidemic tremor , is a hepatovirus ref http www.ruleworks.co.uk poultry Avian Encephalomyelitis.htm Avian Encephalomyelitis AE at The Poultry Guide , retrieved September 14 2011 ref belonging to the Picornavirus family. ref http www.ncbi.nlm.nih.gov pubmed 10092005 Avian encephalomyelitis virus is a picornavirus and is most closely related to hepatitis A virus , Journal of General Virology , 1999 Mar 80 Pt 3 653 62, by Marvil P, Knowles NJ, Mockett AP, Britton P, Brown TD, Cavanagh D ref The first avian picornavirus to have its genome full genome sequencing sequenced , ref http www.picornaviridae.com tremovirus aev aev.htm Avian encephalomyelitis virus at Picornaviridae.com retrieved September 14, 2011 ref it causes epidemic tremor in chicken s. Avian encephalomyelitis is of economic importance to chicken farmers because it causes a drop in egg production in laying hens, and neurological diseases in chicks less than three weeks old. The domestic host for AEV is the chicken , but it can also infect partridge , turkey bird turkey s, quail , guineafowl , and pheasant s. It has a worldwide distribution. ref http jvi.asm.org cgi content short 82 4 1993 The Picornavirus Avian Encephalomyelitis Virus Possesses a Hepatitis C Virus Like Internal Ribosome , Journal of Virology , February 2008, p. 1993 2003, Vol. 82, No. 4, by Mehran Bakhshesh, Elisabetta Groppelli, Margaret M. Willcocks, Elizabeth Royall, Graham J. Belsham, and Lisa O. Roberts ref AE can be spread by both vertical transmission vertical and horizontal transmission . It is not a zoonosis . Symptoms and diagnosis Neurological signs such as ataxia , tremor of the head and neck, drooping wings, weakness , paralysis , exercise intolerance and blindness are seen in chicks ... is by histopathology or virus isolation. ref name WikiVet http en.wikivet.net Avian Encephalomyelitis Avian Encephalomyelitis expert reviewed and published by WikiVet , accessed 10 October 2011. ref ... more details
Latent Autoimmune Diabetes of Adults LADA , also known as Diabetes Type 1.5 , is a term coined by Tuomi et al. in 1993 Diabetes 42 359 362 to describe slow onset Type 1 autoimmune diabetes in adults. The Expert ... LADA in the definition of Type 1 diabetes Type 1 autoimmune diabetes Type 1 diabetes results from a cellular mediated apoptosis autoimmune destruction of the beta cell s of the pancreas. In Type 1 diabetes ... autoimmune disorder that results in the body mistaking the pancreas as foreign and responding ... stated, autoimmune disorders, including LADA, are an allergy to self. Adults with LADA are frequently ... for LADA LADA may be diagnosed using any of the following terms latent autoimmune diabetes of adulthood late onset autoimmune diabetes of adulthood latent autoimmune diabetes of aging ref Diabetes mellitus ... 732 8 ref slow onset type 1 diabetes, or type 1.5 type one and a half diabetes Diagnosing latent autoimmune ... www.annalsnyas.org cgi content full 958 1 112 Latent Autoimmune Diabetes in Adults Mona Landin Olsson ... date August 2010 ref Moreover, it is now becoming evident that autoimmune diabetes may be highly ... rather limited use in connections with latent autoimmune diabetes. ref cite journal author Landin Olsson M title Latent autoimmune diabetes in adults journal Annals of the New York Academy of Sciences ... autoimmune diabetes in adults LADA .pdf lada antibodies&hl en&gl us&ct clnk&cd 4 Latent Autoimmune ... diagnosis include ref name oldnote1 http www.isletsofhope.com diabetes symptoms latent autoimmune diabetes lada 1.html Latent Autoimmune Diabetes in Adults Symptoms, Diagnosis, Treatment, and Prognosis ... RD, Williams R, Pozzilli P title Clinical review Type 1 diabetes and latent autoimmune diabetes in adults ... diabetes is sometimes involved regarding a latent autoimmune diabetic adult ref name What is LADA cite ... Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 ... title Latent Autoimmune Diabetes of Adults and Pregnancy Foretelling the Future year 2008 last1 Dunn ... more details
Autoimmune inner ear disease is a suspected autoimmune disease characterized by rapidly progressive bilateral sensorineural hearing loss. ref http www.emedicine.com ent TOPIC496.HTM Inner Ear, Autoimmune eMedicine, 2006 ref It occurs when the body s immune system attacks cells in the inner ear that are mistaken for a virus or bacteria. Autoimmune inner ear disease was first described by Dr. Brian McCabe of the University of Iowa in 1979. Causes AIED is generally caused by either antibodies or immune cells that cause damage to the inner ear. There are several autoimmune disorders to which AIED is related Bystander damage Cross reactions Genetic factors Drug Use opiate based painkillers like OxyContin http www.medicalnewstoday.com articles 121790.php http abcnews.go.com GMA story?id 128270&page 1&page 1 http www.foxnews.com story 0,2933,99731,00.html Research has found that long term abuse of opiate based painkillers such as OxyContin and Hydrocodone can lead to profound hearing loss caused by damage to the inner ear, according to Dr. Gail Ishiyama, an assistant professor at the UCLA department of neurology. http www.foxnews.com story 0,2933,99731,00.html Treatment AIED treatment is a rapidly changing field. Steroids are often used in the treatment of AIED, as well as cytotoxic agents such as Cyclophosphamide and Methotrexate . More recently, in order to avoid many of the side effects of steroids, alternative medications and surgical procedures are used. Since these change quite frequently, it is a good idea to check many sources in locating the most cutting edge procedure for treating autoimmune inner ear disease. ref http www.american hearing.org disorders autoimmune autoimmune.html treated Autoimmune inner ear disease at the American Hearing Research Foundation , Chicago, Illinois 2008. ref Notes reflist External links http entmd.org healthinfo hearing autoimmune.cfm Autoimmune inner ear disease at American Academy of Otolaryngology immunology stub Category Autoimmune ... more details
Infobox Disease LOLHAHHHAHAHAILOVESEANLUVYOUHUN 3 Name Autoimmune polyendocrine syndrome Image Caption DiseasesDB 29212 DiseasesDB mult DiseasesDB2 29690 ICD10 ICD10 E 31 0 e 20 ICD9 ICD9 258.1 ICDO OMIM 240300 OMIM mult OMIM2 269200 MedlinePlus eMedicineSubj med eMedicineTopic 1867 eMedicine mult eMedicine2 med 1868 MeshID D016884 In medicine , autoimmune polyendocrine syndromes are a heterogeneous group ref cite journal author Eisenbarth GS, Gottlieb PA title Autoimmune polyendocrine syndromes journal New England Journal of Medicine N. Engl. J. Med. volume 350 issue 20 pages 2068 79 year 2004 pmid 15141045 doi 10.1056 NEJMra030158 url ref of rare disease s characterised by autoimmune activity against more than one endocrine organ s, although non endocrine organs can be affected. There are three autoimmune polyendocrine syndromes , and a number of other diseases which have endocrine autoimmunity as one of their features. The syndromes Autoimmune polyendocrine syndrome type 1 APECED or Whitaker s syndrome Autoimmune polyendocrine syndrome type 2 Schmidt s syndrome The most serious but rarest form is the Sex linkage X linked polyendocrinopathy, immunodeficiency and diarrhea syndrome, also called IPEX syndrome XLAAD X linked autoimmunity and allergic dysregulation or IPEX syndrome IPEX immune dysfunction, polyendocrinopathy, and enteropathy, X linked . This is due to mutation of the FOXP3 gene on the X chromosome. ref name pmid18481161 cite journal author Yong PL, Russo P, Sullivan KE title Use of Sirolimus in IPEX and IPEX Like Children journal J. Clin. Immunol. volume 28 issue ... diabetes and diarrhea as neonates and many die due to autoimmune activity against many organs .... For example, in a patient with known Type 2 autoimmune polyendocrine syndrome but no features of Addison .... References reflist 2 Endocrine pathology Hypersensitivity and autoimmune diseases Category Endocrine diseases Category Autoimmune diseases Category Rare diseases Category Diseases of immune dysregulaton ... more details
Autoimmune progesterone dermatitis may appear as urticarial papules, deep gyrate lesions, papulovesicular lesions, an eczematous eruption, or as targetoid lesions. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 82 Autoimmune progesterone dermatitis initially manifests with eye symptoms, e.g. burning, and progresses into rashes. Its relapsing remitting pattern in women correspond to the progesterone levels durning the menstrual cycle, which spike twice a month. It is an extremely rare disease, only perhaps 50 cases have ever been reported. See also Skin lesion References reflist Cutaneous condition stub Category Eczema ar ... more details
Autoimmune estrogen dermatitis presents as a cyclic skin disorder that may appear eczematous, papular, bullous, or urticarial. with pruritus typically present, skin eruptions that may be chronic but which are exacerbated premenstrually or occur immediately following menses. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 83 See also Skin lesion References reflist Cutaneous condition stub Category Eczema ... more details
Maternal autoimmune bullous disease is a blistering skin condition that presents at birth. ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref See also Accessory nail of the fifth toe List of cutaneous conditions References reflist Dermatology stub Category Cutaneous congenital anomalies ... more details
Infobox disease Name Warm antibody autoimmune hemolytic anemia ICD10 ICD10 D 59 1 d 55 ICD9 ICD9 283.0 Image Caption ICDO OMIM DiseasesDB 29723 MedlinePlus eMedicineSubj eMedicineTopic Warm Antibody Autoimmune Hemolytic Anemia AIHA is the most common of the Autoimmune diseases autoimmune Hemolysis hemolytic diseases. ref name isbn0 7216 0187 1 cite book author Cotran, Ramzi S. Kumar, Vinay Fausto, Nelson Nelso Fausto Robbins, Stanley L. Abbas, Abul K. title Robbins and Cotran pathologic basis of disease publisher Elsevier Saunders location St. Louis, Mo year 2005 pages 637 isbn 0 7216 0187 1 oclc doi accessdate ref About half of the cases are idiopathic , with the other half attributable to a predisposing condition or medications being taken. Pathophysiology The most common antibody involved in warm antibody AIHA is IgG , though sometimes IgA is found. The IgG antibodies attach to a red blood cell, leaving their F sub C sub portion exposed with maximal reactivity at 37 C versus cold antibody induced hemolytic anemia whose antibodies only bind red blood cells at low body temperatures, typically 28 31 C . The F sub C sub region is recognized and grabbed onto by F sub C sub receptors found on monocytes and macrophages in the spleen . These cells will pick off portions of the red cell ... RS, Chen AR, McDonough C, Lederman HM title Fatal warm autoimmune hemolytic anemia resulting from ... cause ref name Jenkins http www.trcc.org blood 10b autoimmune.pdf AUTOIMMUNE HEMOLYTIC ANEMIA AIHA ... M, Luppi M, Potenza L, et al. title Mixed warm and cold autoimmune hemolytic anemia complete recovery ... A, et al. title Efficacy and safety of rituximab in adults warm antibody autoimmune haemolytic ... 2003 06 hemoglobin 42 due to autoimmune.html warm antibody autoimmune hemolytic anemia with typical laboratory findings. Clinical Cases and Images. Hematology DEFAULTSORT Warm Autoimmune Hemolytic Anemia Category Autoimmune diseases Category Acquired hemolytic anemia Category Hematopathology ... more details
Infobox Disease Name Autoimmune lymphoproliferative syndrome Image Caption DiseasesDB 33425 DiseasesDB ... eMedicineTopic MeshID Autoimmune lymphoproliferative syndrome is a form of lymphoproliferative disorder . It affects lymphocyte apoptosis . ref name pmid18193364 It is a RASopathy . Introduction Autoimmune ... pathway, leading to chronic non malignant lymphoproliferation, autoimmune disease, and secondary ... tends to present at a young age median 11.5 months and may improve with age. Autoimmune disease The second most common clinical manifestation and one that most often requires treatment. Autoimmune ... Autoimmune Hemolytic Anemia Autoimmune Neutropenia Autoimmune Thrombocytopenia Other Can ... Autoimmune cerebellar ataxia Guillain Barre Transverse myelitis GI Autoimmune esophagitis, gastritis, colitis, hepatitis, pancreatitis Derm Urticaria Pulmonary Bronchiolitis obliterans Renal Autoimmune ... in other autoimmune diseases Thought to be cytotoxic T lymphocytes that have lost CD8 expression Unknown ... hematopathologist Autoimmune cytopenias and polyclonal hypergammaglobulinemia Family history of ALPS ... prose section date December 2011 Mostly commonly directed at autoimmune disease Maybe needed ... Most studied medicine in clinical trials Some patients have complete resolution of autoimmune ... agent in clinical trials Most patients have complete resolution of autoimmune disease 90 ref name pmid19208097 ... autoimmune disease Most patients have elimination of peripheral blood DNTs mTOR Akt PI3K pathway may ... in patients that require chronic therapy. Better activity against autoimmune disease and lymphoproliferation ... Reflist refs ref name pmid18193364 cite journal pages 87 92 doi 10.1007 s12026 007 8001 1 title The autoimmune ... title Causes and consequences of the autoimmune lymphoproliferative syndrome year 2006 last1 Rao ... in the management and understanding of autoimmune lymphoproliferative syndrome ALPS year 2010 last1 ... response reveal autoimmune lymphoproliferative syndrome ALPS year 2005 last1 Teachey first1 ... more details
Experimental College may refer to Experimental College movement , a movement for unconventional college classes Experimental College Tufts University , a college at Tufts University Experimental College of the Twin Cities disamb ... more details
Autoimmunity Autoimmune heart disease s are the effects of the body s own Immunity medical immune defense system mistaking cardiac antigens as foreign and attacking them leading to inflammation of the heart as a whole, or in parts. The commonest form of autoimmune heart disease is rheumatic heart disease or rheumatic fever . Mechanism and aetiology These are the typical mechanisms of autoimmunity . Autoantibody Autoantibodies or auto toxic T cell T lymphocyte mediated tissue destruction. The process is aided by neutrophil s, the complement system , tumor necrosis factor alpha , etc. Aetiologically, these are most commonly seen in children with a history of sore throat caused by a streptococcus streptococcal infection . This is similar to the post streptococcal glomerulonephritis . Here, the anti bacterial antibodies cross react with the heart antigens causing inflammation. Inflammatory damage leads to the following Pericarditis Here the pericardium gets inflamed. Acutely, it can cause pericardial effusion leading to cardiac tamponade and death. After healing, there may be fibrosis and adhesion of the pericardium with the heart leading to constriction of the heart and reduced cardiac function. Myocarditis Here the muscle bulk of the heart gets inflamed. Inflamed muscles have reduced functional capacity. This may be fatal, if left untreated as is in a case of pancarditis . On healing, there will be fibrosis and reduced functional capacity. Endocarditis Here the inner lining of the heart is inflamed, including the heart valves . This may cause a Valvular heart disease valve prolapse , adhesion of the adjacent cusps of these valves and occlusion of the flow tracts of blood through the heart causing diseases called Valvular heart disease valve stenosis . Specific clinical manifestations These depend on the amount of inflammation . These are covered in their relevant articles ... 1416025340 See also Autoimmunity Heart Glomerulonephritis DEFAULTSORT Autoimmune heart disease ... more details
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