About a protein protein Name Fatty acid amide hydrolase caption Fatty acid amide hydrolase FAAH dimer shown with covalent inhibitor MAFP , yellow bound in the active site. image Faah w mafp.png width 300 HGNCid 3553 Symbol FAAH AltSymbols EntrezGene 2166 OMIM 602935 RefSeq NM 001441 UniProt O00519 PDB 1MT5 ECnumber 3.5.1. Chromosome 1 Arm p Band 35 LocusSupplementaryData p34 Fatty acid amide hydrolase or FAAH is a member of the serine hydrolase family of enzyme s. It was first shown to breakdown anandamide in 1993 ref name pmid8373432 cite journal author Deutsch DG, Chin SA. title Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. journal Biochem Pharmacol. volume ... . In humans, it is encoded by the gene FAAH . ref name pmid8900284 cite journal author Cravatt BF ... 12459591 doi 10.1126 science.1076535 ref Function FAAH is an integral membrane hydrolase with a single N terminal transmembrane domain. In vitro , FAAH has esterase and amidase activity. ref name ... ref In vivo , FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty ... A, Cravatt BF title A FAAH regulated class of N acyl taurines that activates TRP ion channels ... bi0608008 ref FAAH Knockout mouse knockout mice display highly elevated 15 fold levels of N acylethanolamines ... levels, FAAH KOs have an analgesic phenotype, showing reduced pain sensation in the hot plate test ... ref Finally, because of their impaired ability to degrade anandamide, FAAH KOs also display supersensitivity ... to the ability of FAAH to regulate nociception , it is currently viewed as an attractive drug target ... 622 and PF 750 are more potent and more selective inhibitors of FAAH than URB597. ref name ... have also been described. Structure The first crystal structure of FAAH was published in 2002 PDB ... science.1076535 ref Structures of FAAH with drug like ligands were first reported in 2008, and include ... wiki index.php 2vya Proteopedia FAAH entry interactive structure JMOL of inhibitor bound FAAH Carbon ... more details
FAAH is an abbreviation, acronym, or initialism that may refer to Fatty acid amide hydrolase , a protein found in cell membranes FightAIDS Home , a distributed computing project disambig ... more details
that may be possible in the laboratory. For example, while fatty acid amide hydrolase FAAH can hydrolyze ... or pharmacological disruption of FAAH elevates anandamide but not 2 AG, suggesting that 2 AG is not an endogenous, in vivo substrate for FAAH. ref Cravatt BF, Demarest K, Patricelli MP, Bracey ... 9376. ref In another example, the N acyl taurines NATs are observed to increase dramatically in FAAH disrupted animals, but are actually poor in vitro FAAH substrates. ref Saghatelian A, Trauger SA ... more details
Scott Kurowski is an entrepreneurial software technologist and inventor. In 1997 he founded Entropia, Inc. company Entropia , a venture capital funded company law company selling grid computing or distributed computing software . In 2000, he built a grid computing system searching for HIV protease inhibitors for The Scripps Research Institute. In 2002 he helped launch Digital Orchid, a branded mobile wireless digital media solutions company law company using technology acquired from Discovercast. GIMPS PrimeNet Server He also continues to run the http www.mersenne.org primenet Internet PrimeNet Server that supports Great Internet Mersenne Prime Search GIMPS , one of the earliest and most successful grid computing projects, researching Mersenne prime numbers. Scott Kurowski wrote the PrimeNet server software that supports distributed computing to demonstrate Entropia distributed computing software. He is Executive Vice President and board director of http v5www.mersenne.org legal Mersenne Research Inc. See also GIMPS FAAH External links http www.scottkurowski.com Scott Kurowski s Web Site http www.digitalorchid.com Digital Orchid, Inc. http www.discovercast.com Discovercast, Inc. http www.entropia.com Entropia, Inc. http v5www.mersenne.org PrimeNet grid http fightaidsathome.scripps.edu FAAH grid Persondata Metadata see Wikipedia Persondata . NAME Kurowski, Scott ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Kurowski, Scott Category American computer scientists Category Living people compu bio stub ... more details
Drugbox verifiedrevid 419371651 IUPAC name 5 Z ,8 Z ,11 Z ,14 Z N 4 hydroxyphenyl icosa 5,8,11,14 tetraenamide image AM404 skel.svg width 240 Clinical data tradename legal status routes of administration Pharmacokinetic data elimination half life excretion Identifiers CASNo Ref cascite ?? ?? CAS number 183718 77 6 CAS supplemental CAS 198022 70 7 PubChem 6604822 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 5037081 ChEMBL Ref ebicite correct EBI ChEMBL 39878 Chemical data C 26 H 37 N 1 O 2 molecular weight 395.577 g mol smiles O C Nc1ccc O cc1 CCC C C C C C C C C C C C CCCCC InChI 1 C26H37NO2 c1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 26 29 27 24 20 22 25 28 23 21 24 h6 7,9 10,12 13,15 16,20 23,28H,2 5,8,11,14,17 19H2,1H3, H,27,29 b7 6 ,10 9 ,13 12 ,16 15 InChIKey IJBZOOZRAXHERC DOFZRALJBG StdInChI Ref stdinchicite correct chemspider StdInChI 1S C26H37NO2 c1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 26 29 27 24 20 22 25 28 23 21 24 h6 7,9 10,12 13,15 16,20 23,28H,2 5,8,11,14,17 19H2,1H3, H,27,29 b7 6 ,10 9 ,13 12 ,16 15 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey IJBZOOZRAXHERC DOFZRALJSA N AM404 , also known as N 4 hydroxyphenyl arachidonoylethanolamide , is an activity chemistry active metabolite of paracetamol acetaminophen , responsible for all or part of its analgesic action. ref cite pmid 16438952 ref Pharmacology AM404 was originally reported to be an endogenous cannabinoid reuptake inhibitor , preventing the transport of anandamide and other related compounds back from the synapse synaptic cleft , much in the same way that common SSRI antidepressants prevent the reuptake of serotonin . Recent work on the mechanism of AM404 has suggested that the inhibition of fatty acid amide hydrolase FAAH by AM404 is likely responsible for all of its attributed reuptake properties, since intracellular FAAH hydrolysis of anandamide changes the intra extracellular anandamide equilibrium. ref cite pmid 12655057 ref AM404 is also a T ... more details
Chembox ImageFile LY 2183240 structure.png ImageSize IUPACName N,N dimethyl 5 4 biphenyl methyl tetrazole 1 carboxamide OtherNames Section1 Chembox Identifiers CASNo 874902 19 9 PubChem 11507802 ChemSpiderID SMILES CN C C O n1nnnc1Cc2ccc cc2 c3ccccc3 Section2 Chembox Properties Formula C sub 17 sub H sub 17 sub N sub 1 sub O sub 1 sub MolarMass 307.349 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition LY 2183240 is a drug which acts both as a potent inhibitor of the reuptake of the endocannabinoid anandamide , and as an inhibitor of fatty acid amide hydrolase FAAH , the primary enzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY 2183240 has been shown to produce both analgesic and anxiolytic effects in animal models. ref Dickason Chesterfield AK, Kidd SR, Moore SA, Schaus JM, Liu B, Nomikos GG, Felder CC. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cellular and Molecular Neurobiology . 2006 Jul Aug 26 4 6 407 23. PMID 16736384 ref ref Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Journal of the American Chemical Society . 2006 Aug 2 128 30 9699 704. PMID 16866524 ref ref Maione S, Morera E, Marabese I, Ligresti A, Luongo L, Ortar G, Di Marzo V. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation cannabinoid and non cannabinoid receptor mediated mechanisms. British Journal of Pharmacology . 2008 Nov 155 5 775 82. PMID 18660824 ref ref Powers MS, Barrenha GD, Mlinac NS, Barker EL, Chester JA. Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear potentiated startle and alcohol seeking behaviors in mice selectively bred for high alcohol preference. Psychopharmacology Berlin . 2010 Dec 212 4 571 83. PMID 20838777 ref See also URB 597 R ... more details
chembox verifiedrevid 424696969 ImageFile jzl184 2structures.png ImageSize IUPACName 4 nitrophenyl 4 bis 1,3 benzodioxol 5 yl hydroxy methyl piperidine 1 carboxylate OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct ?? CASNo PubChem SMILES MeSHName Section2 Chembox Properties Formula C sub 27 sub H sub 24 sub N sub 2 sub O sub 9 sub MolarMass 520.15 g mol Appearance Pale yellow solid Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition JZL184 is an irreversible enzyme inhibitor inhibitor for monoacylglycerol lipase MAGL , the primary enzyme responsible for degrading the endocannabinoid 2 arachidonoylglycerol 2 AG . ref name pmid19029917 cite journal author Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pav n FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF title Selective blockade of 2 arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects journal Nat. Chem. Biol. volume 5 issue 1 pages 37 44 year 2008 month November pmid 19029917 doi 10.1038 nchembio.129 url pmc 2605181 ref It displays high selectivity for MAGL over other brain serine hydrolase s, including the anandamide degrading enzyme fatty acid amide hydrolase FAAH , thereby making it a useful tool for studying the effects of endogenous 2 AG signaling, in vivo . Administration of JZL184 to mice was reported to cause dramatic elevation of brain 2 AG leading to several tetrad test cannabinoid related behavioral effects . See also JZL195 References div class references small references div Cannabinoids Category Cannabinoids Category Benzodioxoles Category Alcohols Category Piperidines Category Carbamates Category Nitrobenzenes Cannabinoid stub fa ... more details
by the fatty acid amide hydrolase FAAH enzyme, which converts anandamide into ethanolamine and arachidonic acid . As such, inhibitors of FAAH lead to elevated anandamide levels and are being pursued ... to the action of the enzyme fatty acid amide hydrolase FAAH , which breaks it down into free arachidonic ... combined with arachidonic acid by FAAH to form AM404 . ref name AM404 cite doi 10.1074 jbc.M501489200 ... more details
Infobox scientist name Benjamin F Cravatt image image size caption birth date birth place death date death place residence citizenship nationality ethnicity field Chemical Biology work institution The Scripps Research Institute br ActivX Biosciences alma mater doctoral advisor doctoral students known for Proteomics author abbreviation bot author abbreviation zoo prizes religion footnotes Benjamin Franklin Cravatt is a professor in and chair of the Department of Chemical Physiology at The Scripps Research Institute in La Jolla, California . Considered the co inventor of activity based proteomics with Matthew Bogyo, he is a prominent figure in the nascent field of chemical biology . Cravatt attended Stanford University , earning BS in the Biological Sciences and a BA in History. ref cite journal last Bogyo first Matthew coauthors Cravatt, Benjamin F. title Genomics and proteomics From genes to function advances in applications of chemical and systems biology journal Current Opinion in Chemical Biology year 2007 volume 11 pages 1 3 doi 10.1016 j.cbpa.2006.12.029 ref He then received a PhD in Macromolecular and Cellular Structure and Chemistry from The Scripps Research Institute in 1996, where he worked under the joint supervision of Dale L. Boger and Richard Lerner . His early contributions to the cannabinoid field include identification and characterization of the endocannabinoid terminating enzyme fatty acid amide hydrolase, FAAH , as well as the isolation of the novel soporific compound oleamide from cerebrospinal fluid . ref Cravatt B.F., Giang D.K., Mayfield S.P., Boger D.L., Lerner, R.A. Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides Nature 384 83 1996 . DOI 10.1038 384083a0 PMID 8900284 ref ref Cravatt BF, Prospero Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical characterization of a family of brain lipids that induce sleep. Science . 1995 268 5216 1506 9. DOI 10.1126 science.7770779 PMID 77707 ... more details
This is a listing of the horses that finished in either first, second, or third place and the number of starters in the Dancing Count Stakes , an United States American stakes race for three year olds at six furlongs on dirt held at Laurel Park Racecourse in Baltimore, Maryland . ref Stakes Histories, The Original Racing Almanac 2009, page 184 on June 26, 2008. ref List 1985 present class wikitable sortable border 1 cellpadding 0 style border collapse collapse font size 90 bgcolor DACAA5 align center width 45px Year br width 130px Winner br width 125px Second br width 125px Third br width 55px Starters align center 2012 Beggarthyneighbor Trippi s Secret Ill Conceived align center 7 align center 2011 Wicked Thunder Diski Dancer Afternoon Action align center 8 bgcolor eeeeee align center 2010 No Race No Race No Race align center n a align center 2009 Russell Road Great Love St John s Gospel align center n a align center 2008 Vanderkaay Ghostly Thunder Vigors Storm align center n a align center 2007 Heart Throbbin Place Your Bet Crafty Bear align center n a align center 2006 Great Senaca Ah Day The Village Vicar align center n a align center 2005 More Smoke Timely Impulse Primal Storm align center n a align center 2004 Kiowa Prince Basketball Court Hands On align center n a align center 2003 Philadelphia Gym Gimmeawink For Gold align center n a align center 2002 President Butler Sothern Livin Coach Knight align center n a align center 2001 Sea of Green Faah Emiss My Golden Sun align center n a align center 2000 Gangsta Rap Chief J. Strongbow Tricky Di align center n a align center 1999 Mr. Katowice Twilight Princess Tom s Revenge align center n a align center 1998 Just Call Me Carl Unreal Madness Running Copelan align center n a align center 1997 Balanced Budget For Real Zeal Anttietam Creek align center n a align center 1996 In Contention Viv Irish Cloud align center n a align center 1995 Onto Luck He s Got Gall Without Remorse align center n a align center 1994 Can t ... more details
hydrolase FAAH , which cleaves anandamide into arachidonic acid and ethanolamine or monoacylglycerol ... . Emerging data in the field also points to FAAH being expressed in postsynaptic neurons complementary ... doi 10.1002 hipo.20151 ref NPs in the hippocampus have been shown to possess FAAH and express CB ... more details
Pfam box Symbol PI3 PI4 kinase Name Phosphatidylinositol 3 and 4 kinase image PI3kinase.png width caption PI3 Kinase 110 gamma bound to the inhibitor PIK 93 yellow . ref name pmid16647110 PDB 2chz cite journal author Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM title A pharmacological map of the PI3 K family defines a role for p110alpha in insulin signaling journal Cell volume 125 issue 4 pages 733 47 year 2006 month May pmid 16647110 doi 10.1016 j.cell.2006.03.035 url pmc 2946820 ref Pfam PF00454 InterPro IPR000403 SMART SM00146 PROSITE PDOC00710 SCOP 3gmm TCDB OPM family OPM protein PDB PDB2 1cja , PDB2 1e7u , PDB2 1e7v , PDB2 1e8w , PDB2 1e8x , PDB2 1e8y , PDB2 1e8z , PDB2 1e90 , PDB2 1he8 , PDB2 2a4z , PDB2 2a5u , PDB2 2chw , PDB2 2chx , PDB2 2chz Phosphatidylinositol 3 kinases PI 3 kinases or PI3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In response to lipopolysaccharide , PI3K phosphorylates p65 , inducing anandamide synthesis to inhibit NF B activation. This is under the control of Fatty acid amide hydrolase FAAH limiting the ability of LPS to increase AEA levels and is also inhibited by wortmannin and cannabidiol , one of the only natural compounds to inhibit FAAH. ref name Jie Liu, S ndor B tkai, P l Pacher, Judith Harvey White, Jens A. Wagner, Benjamin F. Cravatt, Bin Gao, George Kunos 2003 cite journal author Jie Liu, S ndor B tkai, P l Pacher, Judith Harvey White, Jens A. Wagner, Benjamin F. Cravatt, Bin Gao, George Kunos title Lipopolysaccharide Induces Anandamide Synthesis in Macrophages via CD14 MAPK Phosphoinositide 3 Kinase NF B Independently of Platelet activating Factor journal The Journal of Biological Chemistry doi 10.1074 jbc.M306062200 url ref ref name pmid21175579 cite journal auth ... more details
FAAH . It is a user friendly web sever for the prediction of binding affinity of small chemical molecules against FAAH. http crdd.osdd.net raghava kidoq KiDoQ KiDoQ, a web server has been developed ... more details
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