282 283 Fluorouracil 5 FU or f5U sold under the brand names Adrucil , Carac , Efudix , Efudex and Fluoroplex ... PG title 5 fluorouracil mechanisms of action and clinical strategies journal Nat. Rev. Cancer ... excessive scarring at the trabeculectomy site is the main cause for failure of the surgery. Fluorouracil ... , Carac or Fluoroplex . Due to fluorouracil s toxicity and the fact that it can be manufactured using ... author Chu E title Ode to 5 Fluorouracil journal Clinical Colorectal Cancer volume 6 issue 9 ... fluorine is reacted with uracil, 5 fluorouracil is produced. 5 Fluorouracil masquerades as uracil during the nucleic acid replication process. Because 5 fluorouracil is similar in shape to but does ... Raghunathan K, Priest DG title Modulation of fluorouracil antitumor activity by folic acid in a murine ... author Tucker JM, Davis C, Kitchens ME, et al. title Response to 5 fluorouracil chemotherapy is modified ... studies were needed. ref http books.google.com books?id mst5gVH6WUcC&pg PA207&lpg PA207&dq Fluorouracil ... Trissel LA, Martinez JF, Xu QA title Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin ... C title Routine dihydropyrimidine dehydrogenase testing for anticipating 5 fluorouracil related ... enzyme, asked Robert Duschinsky and Robert Schnitzer at Hoffman La Roche to synthesize fluorouracil ... that 5 fluorouracil markedly inhibited tumors in mice. ref cite journal author Cohen, Seymour ... Individualdrugs Fluorouracil Cancerbackup.org.uk &ndash Fluorouracil s use in cancer Chemotherapeutic ... hr Fluorouracil id Fluorouracil it Fluorouracile nl 5 fluorouracil ja pl Fluorouracyl pt Fluorouracila ru sl Fluorouracil zh 5 ... more details
Cyclophosphamide Methotrexate Fluorouracil CMF is a commonly used Chemotherapy regimens regimen of breast cancer chemotherapy that combines three anti cancer agents cyclophosphamide , methotrexate , and Fluorouracil 5 fluorouracil 5 FU . ref name pmid18306034 cite journal author Kimmick GG, Cirrincione C, Duggan DB, et al. title Fifteen year median follow up results after neoadjuvant doxorubicin, followed by mastectomy, followed by adjuvant cyclophosphamide, methotrexate, and fluorouracil CMF followed by radiation for stage III breast cancer a phase II trial CALGB 8944 journal Breast Cancer Res. Treat. volume 113 issue 3 pages 479 90 year 2008 pmid 18306034 doi 10.1007 s10549 008 9943 2 ref . While it is no longer considered most efficient all around chemotherapy it retains a great importance in the treatment of elderly patients with luminal cancers and may become important for the treatment of estrogen receptor negative androgen receptor positive luminal GATA3 expressing breast cancer. The regimen was designed in order to mimic the highly successful regimen developed to treat Hodgkin s lymphoma . ref name classic cite journal author Ferreira Filho AF, Di Leo A, Paesmans M et al. title The feasibility of classical cyclophosphamide, methotrexate, 5 fluorouracil CMF for pre and post menopausal node positive breast cancer patients in a Belgian multicentric trial a study of consistency in relative dose intensity RDI and cumulative doses across institutions journal Annals of Oncology volume 13 issue 3 pages 416 421 year 2002 url http annonc.oxfordjournals.org cgi content full 13 3 416 pmid 11996473 doi 10.1093 annonc mdf051 ref Treatment The treatment is administrated over a four week cycle. On days 1 and 8 methotraxate and 5 FU are given as injections. Cyclophosphamide may be also administered intravenously in conjunction with these drugs, or may be taken as an oral tablet ..., methotrexate and 5 fluorouracil accessdate 2008 10 13 publisher Breakthrough Breast ... more details
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer . It is made up of the following drugs FOL folinic acid leucovorin , a vitamin B derivative used as a rescue drug for high doses of the drug methotrexate and that modulates potentiates reduces the side effects of fluorouracil F fluorouracil 5 FU , a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops synthesis and IRI irinotecan Camptosar , a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating. Cetuximab , a monoclonal antibody to epidermal growth factor receptor , is sometimes added to FOLFIRI. ref NEJM 360 1408 ref The regimen consists of Irinotecan 180 mg m IV over 90 minutes concurrently with folinic acid 400 mg m or 2 x 250 mg m IV over 120 minutes . Followed by fluorouracil 400 500 mg m IV bolus then fluorouracil 2400 3000 mg m intravenous infusion over 46 hours . This cycle is typically repeated every two weeks. The dosages shown above may vary from cycle to cycle. Also see IFL chemotherapy Dose dense chemotherapy References Reflist Chemotherapeutic Agents DEFAULTSORT Folfiri Category Chemotherapy regimens antineoplastic drug stub de FOLFIRI ja FOLFIRI ... more details
IFL is a chemotherapy regimen for treatment of certain cancers, consisting of concurrent treatment with irinotecan , leucovorin folinic acid , and fluorouracil . It is similar to the FOLFIRI regimen and uses the same drugs. However, the flurouracil component is given as a bolus injection rather than as an infusion over 48 hours. See also Dose dense chemotherapy Chemotherapeutic Agents Category Chemotherapy regimens treatment stub ... more details
, fluorouracil 5 FU Breast cancer CAV Cyclophosphamide , Adriamycin doxorubicin , vincristine Lung cancer ... in patients with history of cardiovascular disease Cyclophosphamide, methotrexate and fluorouracil CMF Cyclophosphamide , methotrexate , fluorouracil 5 FU Breast cancer COPP chemotherapy COPP Cyclophosphamide ... cancer ECF Epirubicin , cisplatin , fluorouracil 5 FU Gastric cancer and oesophageal cancer EP Etoposide ... , Oncovin , cyclophosphamide , and hydroxydaunorubicin Lymphomas FEC Fluorouracil 5 FU , epirubicin , cyclophosphamide Breast cancer FL Also known as Mayo Fluorouracil 5 FU , leucovorin folinic acid Colorectal cancer FOLFOX Fluorouracil 5 FU , leucovorin folinic acid , oxaliplatin Colorectal cancer FOLFIRI Fluorouracil 5 FU , leucovorin folinic acid , irinotecan Colorectal cancer ICE chemotherapy ... exclusively to DPD Deficiency and Fluorouracil 5 FU Toxicity related issues dpd deficiency.com Chemotherapeutic ... more details
Image Pyrimidin.svg thumb right Pyrimidine Pyrimidinediones are a class of chemical compounds characterized by a pyrimidine ring substituted with two carbonyl groups. Examples include naturally occurring metabolite s class wikitable Trivial name IUPAC name Structure Pathway Uracil Pyrimidine 2,4 1 H ,3 H dione Image Uracil.svg Pyrimidine biosynthesis Thymine 5 Methylpyrimidine 2,4 1 H ,3 H dione File Thymine chemical structure.png 150px Pyrimidine biosynthesis 5,6 Diaminopyrimidine 2,4 1 H ,3 H dione Riboflavin biosynthesis and drugs Image Primidone.png thumb right Primidone Fluorouracil Idoxuridine Primidone Trifluridine References http www.biam2.org www Cla20291.html Classe PYRIMIDINEDIONE heterocyclic stub Category Pyrimidinediones fr Pyrimidinedione ja sr Pirimidindion zh ... more details
This is a list of specific Wiktionary pharmacological agent pharmacologic agents that are known to be of use in the treatment of cancer , otherwise known as Wiktionary chemotherapeutic agent chemotherapeutic agents . This list is organized by type of agent, though the subsections are not necessarily definitive and are subject to revision. Each drug is listed once at present , though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing. Expand list date August 2008 Alkylating agents Cyclophosphamide Mechlorethamine Chlorambucil Melphalan Anthracyclines article on anthracycline s Daunorubicin Doxorubicin Epirubicin Idarubicin Mitoxantrone Valrubicin Cytoskeletal disruptors Taxanes Paclitaxel Docetaxel Epothilones article on epothilone s Histone Deacetylase Inhibitors Vorinostat Romidepsin Inhibitors of Topoisomerase II Etoposide Teniposide Tafluposide Kinase Inhibitors Bortezomib Erlotinib Gefitinib Imatinib Vismodegib Monoclonal Antibodies Bevacizumab Cetuximab Ipilimumab Ofatumumab Ocrelizumab Panitumab Rituximab Vemurafenib Nucleotide analogs and precursor analogs Azacitidine Azathioprine Capecitabine Cytarabine Doxifluridine Fluorouracil Gemcitabine Hydroxyurea Mercaptopurine Methotrexate Tioguanine formerly Thioguanine Peptide antibiotics Bleomycin Actinomycin Platinum based agents Carboplatin Cisplatin Oxaliplatin Retinoids Tretinoin Alitretinoin Bexarotene Vinca alkaloids and derivatives Vinblastine Vincristine Vindesine Vinorelbine Full alphabetical listing Actinomycin All trans retinoic acid Azacitidine Azathioprine Bleomycin Bortezomib Carboplatin Capecitabine Cisplatin Chlorambucil Cyclophosphamide Cytarabine Daunorubicin Docetaxel Doxifluridine Doxorubicin Epirubicin Epothilone Etoposide Fluorouracil Gemcitabine Hydroxyurea Idarubicin Imatinib Mechlorethamine Mercaptopurine Methotrexate Mitoxantrone Oxaliplatin Paclitaxel Pemetrexed Teniposide Tioguanine Valrubicin Vinblastine Vincristine Vindesin ... more details
2 h day 1 2 Fluorouracil u F u luorouracil 400 mg m IV bolus 2 min day 1 2 u F u luorouracil 600 ... A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations ... more details
TPF may refer to Tibial plateau fracture Tactical Patrol Force, slang term for riot control squad Transaction Processing Facility , an operating system by IBM Terrestrial Planet Finder , a proposed system of telescopes to detect extrasolar planets The Pop Factory , a Welsh television program The Perl Foundation , a non profit organization The Proud Family , a Disney Channel Original Series Tapered polymer fiber , a type of laser Taxotere , paclitaxel , and fluorouracil , a chemotherapy regimen used in head and neck cancer Tokyopop , a manga publishing company Telangana Praja Front , a political party Tribunal p nal f d ral , the Swiss Supreme Court for criminal matters Peter O. Knight Airport , IATA airport code Tooting Popular Front, a fictional revolutionary organisation in Citizen Smith The Purse Forum, a popular online forum dedicated to the discussion of fashion and luxury goods National Treatment Purchase Fund , the Irish healthcare programme Tachi Palace Fights , an United States American Mixed Martial Arts promotion. disambig de TPF fr TPF it TPF nl TPF ja TPF ... more details
Methotrexate Fluorouracil CMF cyclophosphamide , methotrexate , and 5 fluorouracil given 4 weekly for 6 cycles FAC or CAF 5 fluorouracil , doxorubicin , cyclophosphamide given 3 weekly for 6 cycles ... , and cyclophosphamide given 3 weekly for 6 cycles FEC 5 fluorouracil , epirubicin and cyclophosphamide ... more details
CMF , a three letter acronym, may stand for California Medical Facility , a male only state prison in CA, USA Campus MovieFest , the world s largest student film festival Centre of mass frame in mechanics Certificate of Management Fundamentals , a management certification from the Commonwealth of Kentucky. Chaikin Money Flow , a technical stock chart indicator Chern Medal Foundation , an organization that bestows the Chern Medal Award in mathematics Christian Medical Fellowship , an evangelical, interdenominational organisation that links together Christian doctors and medical students in the UK IATA code for Chamb ry Airport , in Savoie, France The Citizens Military Force s, historic reserve units of the Australian Army Color matching fields or functions, a triplet of spectral sensitivity curves in color vision modeling. See CIE 1931 color space Color matching functions Content Management Framework for customizing management of media content Combined Maritime Forces , Naval Force of United Nations Country Music Foundation , a non profit, educational organisation, operating The Country Music Hall of Fame and Museum Creative Music File , an Adlib MIDI hybrid music format developed by Creative Labs Cyclophosphamide, methotrexate and fluorouracil , a chemotherapy regimen commonly used in treating breast cancer Canada Media Fund , a not for profit public private partnership which financially supports the creation of Canadian television and new media The Claretians Congregatio Missionariorum Filiorum disambig de CMF fr CMF it CMF nl CMF ja CMF pl CMF pt CMF ... more details
ECF may refer to Science, technology and medicine Extracellular fluid , body fluid outside of cells Electrochemical fluorination , technology for production of fluorocarbons Elemental chlorine free , a form of paper bleaching that does not use elemental chlorine ECF, a chemotherapy regimen for the treatment of gastric and esophageal cancers consisting of epirubicin, cisplatin, and fluorouracil Eye controlled focusing , for autofocus SLR cameras Organisations Economic Cooperation Foundation , a non governmental entity in Israel English Chess Federation , the governing chess organisation in England European Climate Forum , a platform for joint studies and science based stakeholder dialogue on climatic change European Cultural Foundation , an independent European foundation European Curling Federation European Cyclists Federation , an umbrella organisation for European cycling organisations Other E Cigarette Forum, the world s largest e cigarette forum Enterprise Capital Fund , a UK specific type of venture capital Electronic Case Filing System , an automated system for prosecution of criminal offenses Electronic court filing , the automated transmission of court documents between legal agencies and courts disambiguation de ECF fr ECF ja ECF fi ECF ... more details
image Generalized eruptive keratoacanthomas of Grzybowski.jpg 220px thumb right Picture of the face of a patient Generalized eruptive keratoacanthomas of Grzybowski Generalized eruptive keratoacanthoma also known as Generalized eruptive keratoacanthoma of Grzybowski is a cutaneous condition, a variant of keratoacanthoma s, characterized by hundreds to thousands of tiny follicular keratotic papule s over the entire body. ref name Fitz2 Freedberg, et. al. 2003 . Fitzpatrick s Dermatology in General Medicine . 6th ed. . McGraw Hill. ISBN 0071380760. ref rp 763 ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0721629210. ref rp 645 Treatment Treatments are not successful for many patients with Generalized eruptive keratoacanthoma. Use emollients and anti itch medications can ease some symptoms. Improvement or complete resolutions of the condition has occurred with the application of the following medications Acitretin Isotretinoin Fluorouracil Methotrexate Cyclophosphamide Epidemiology The epidemiology of Generalized eruptive keratoacanthoma remains unknown. See also Keratoacanthoma Nail anatomy Nail anatomy List of cutaneous conditions References reflist Epidermal growth stub Category Epidermal nevi, neoplasms, cysts ... more details
wiktionary FEC is an acronym which may refer to Foreign exchange certificate , a type of currency Federal Election Commission Forward error correction , a system of error control for data transmission Family entertainment center , a small amusement park or indoor equivalent intended for family fun Fellow of Engineers Canada Frank Erwin Center , a multi purpose facility on the campus of the University of Texas Businesses and Organizations Far Eastern College , founded in 1919 in the City of Manila, Philippines Florida East Coast Railway , an American railroad instrumental in the economic development of Florida Family Equality Council , advocates for families headed by same sex couples Federal Election Commission , administers and enforces campaign finance legislation in the United States Far Eastern Commission , policy making commission for post war Japan Federaci n Ecuatoriana de Ciclismo , national governing body of cycle racing in Ecuador Fec Publishing , an imprint of the German group VDM Publishing devoted to the reproduction of Wikipedia content Further education College, mainly used in connection with education in the United Kingdom Farnell company , UK distributor of electronic components Federation of Egalitarian Communities , a group of intentional communities that subscribe to the same principles Food Editors Club Germany , an association of specialist culinary journalists in Germany. Medicine Fecal Egg Count , a procedure for determining worm burden in livestock Chemotherapy regimen Fluorouracil epirubicin cyclophosphamide, a chemotherapy treatment for breast cancer Technology Fast Ethernet Channel, the original name of EtherChannel , is a method for bundling Ethernet channels Focused expression coverage , a type of condition code coverage used in the verification of hardware described by hardware description languages Forward error correction , in digital communications coding Forwarding equivalence class , in Multiprotocol Label Switching disambiguation ... more details
selfref On Wikipedia, FL may refer to Wikipedia Featured lists . wiktionary fl fl. Fl FL FL or variations may refer to TOCright Places Florida United States postal abbreviation Fort Lauderdale, Florida , a city in Florida F rstentum Liechtenstein Principality of Liechtenstein Businesses and organizations AirTran Airways IATA airline code FL Group , an Icelandic investment company with an emphasis on flight and tourism industry Foot Locker, Inc. ticker symbol The Football League in England Measures Femtolitre , a metric unit of volume Foot lambert , a unit of luminance Flawless, a grade of diamond clarity Flight level , a standard nominal altitude of an aircraft, in hundreds of feet Fork length, a standard fish measurement Forestay length, in sailing Denotes fluid in fluid ounce fl oz Mathematics and computing FL complexity , a class of functions in complexity theory FL programming language FL Studio , a music production software program Freelancer computer game Numismatics Florin disambiguation Florin , various coins Guilder , various coins also sometimes called florin Other International license plate code for Liechtenstein Fastest lap in motorsports Foreign language The Flaming Lips , an American rock band Freelancer , a self employed professional fl., floruit Latin, flourished , used to indicate periods when a person, organization, or species was influential fl , a common typographical ligature Fluorouracil 5 FU and leucovorin folinic acid , a Chemotherapy regimens chemotherapy regimen for treating colon cancer Follicular lymphoma in medicine Fluffy transcription factor FLT3LG Fms related tyrosine kinase 3 ligand Federal League , a US baseball league in 1914 Floor , the floor number in a highrise structure also called storey Fl., the abbreviation of the Roman praenomen gens Flavius disambiguation cs FL de FL el FL eo FL fa FL fr FL ko FL it FL sw FL nl FL ja FL no FL pt FL ro FL sl FL fi Fl sv FL tr FL ... more details
In pharmacology , Enteral Greek, enteros Intestine is a term used to describe routes of drug administration that involve absorption of the drug through the gastrointestinal tract . The term may also be used to describe something as residing in the gastrointestinal tract. This is contrasted with the term parenteral Greek para Besides enteros Intestine , meaning outside the intestines , or more specifically in pharmacology Methods of introducing drugs or substances into the body other than through the gastrointestinal tract, via, for example, intravenous injection . Forms of enteral administration Enteral administration may be divided into two different categories, oral and rectal. class wikitable colspan 2 style text align center Oral administration Rectal administration Solids Liquids style text align center Pill pharmacy Pill Solution Ointment Tablet pharmacy Tablet Softgel Suppository Time release technology Suspension chemistry Suspension Enema OROS Osmotic controlled release capsule Emulsion Murphy drip Syrup Nutrient enema Elixir Tincture hydrogel Drug absorption from the intestine The mechanism for drug absorption from the intestine is for most drugs passive transfer, a few exceptions include levodopa and fluorouracil , which are both absorbed through carrier mediated transport . For passive transfer to occur, the drug has to diffuse through the lipid cell membrane of the epithelial cells lining the inside of the intestines. The rate at which this happens is largely determined by two factors Ionization and lipid solubility . ref cite book last Rang first H. P. title Rang and Dale s Pharmacology year 2007 publisher Elsevier isbn 0 443 06911 5 pages 104 ref Factors influencing gastrointestinal absorption Gastrointestinal motility . Splanchnic blood flow. Particle size and formulation. Physicochemical factors. First pass metabolism Drugs given by enteral administration may be subjected to significant first pass metabolism , and therefore, the amount of drug enter ... more details
File Nci vol 8631 300 George Canellos.jpg thumb George P. Canellos 1975 George P. Canellos is a renowned American oncologist and cancer researcher. His research career spans many decades as well as several areas of therapeutic agents for the treatment of malignant diseases. He is perhaps most known for his work with Vincent T. DeVita in which he developed the combination chemotherapy Cyclophosphamide, methotrexate and fluorouracil CMF , ref http www.ncbi.nlm.nih.gov pubmed 1259283?ordinalpos 6&itool EntrezSystem2.PEntrez.Pubmed.Pubmed ResultsPanel.Pubmed RVDocSum Combination chemotherapy for advanced breast cance... Ann Intern Med. 1976& 93 PubMed Result Bot generated title ref which was one of the first combination therapies for breast cancer . The two also collaborated to create the MOPP regimen for Hodgkin s lymphoma . ref DeVita V, Simon R, Hubbard S, Young R, Berard C, Moxley J, Frei E, Carbone P, Canellos G 1980 . Curability of advanced Hodgkin s disease with chemotherapy. Long term follow up of MOPP treated patients at the National Cancer Institute. . Ann Intern Med 92 5 587 95. PMID 6892984 ref As former chair of the Lymphoma Committee of the Cancer and Leukemia Group B CALGB , a national American cooperative trials group, Dr. Canellos initiated many practice changing clinical trials of cancer therapies. He was also the Editor in Chief of the Journal of Clinical Oncology from 1988 to 2001. He is currently one of the senior clinicians at the Dana Farber Cancer Institute and the Brigham and Women s Hospital as well as the William Rosenberg Professor of Medicine at Harvard Medical School . References references Persondata Metadata see Wikipedia Persondata . NAME Canellos, George ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Canellos, George Category Year of birth missing living people Category Living people Category Oncologists Category Cancer researchers Category Harvard Medical School faculty ... more details
Thymidylate synthase inhibitors are chemical agents which enzyme inhibitor inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy . ref name Jackman and Calvert cite journal last1 Jackman first1 A.L. last2 Calvert first2 A.H. year 1995 title Folate based thymidylate synthase inhibitors as anticancer drugs journal Annals of Oncology volume 6 issue 9 pages 871 881 url http annonc.oxfordjournals.org content 6 9 871.abstract ref Five agents were in clinical trials in 2002 raltitrexed , pemetrexed , nolatrexed , ZD9331 , and GS7904L . ref name urlThymidylate synthase inhibitors as anticancer agents from bench to bedside Cite web url http cat.inist.fr ?aModele afficheN&cpsidt 15072905 title Thymidylate synthase inhibitors as anticancer agents from bench to bedside format work accessdate 2009 01 28 ref Examples include Raltitrexed, used for colorectal cancer since 1998 Fluorouracil , used for colorectal cancer ref name pmid10631692 Cite journal author Papamichael, D. title The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer current status journal Oncologist volume 4 issue 6 pages 478 87 year 1999 pmid 10631692 doi url http theoncologist.alphamedpress.org cgi pmidlookup?view long&pmid 10631692 ref BGC 945 ref name Gibbs BGC 945 cite journal author Gibbs, David D., et al year 2005 title BGC 945, a novel tumor selective thymidylate synthase inhibitor targeted to folate receptor overexpressing tumors journal Cancer Research volume 65 issue 24 pages 11721 11728 doi 10.1158 0008 5472.CAN 05 2034 url http cancerres.aacrjournals.org content 65 24 11721.abstract ref References Reflist 2 Enzyme inhibition Intracellular chemotherapeutic agents Biochem stub Oncology stub Category Antineoplastic antimetabolites Category Thymidylate synthase inhibitors ... more details
of chemotherapy doxorubicin , herceptin , paclitaxel , docetaxel , cyclophosphamide , fluorouracil ... that has been removed surgically. Fluorouracil is one effective agent. Citation needed date April ... Paclitaxel Cyclophosphamide Fluorouracil Methotrexate Epirubicin Combination adjuvant chemotherapy ..., and fluorouracil Cyclophosphamide, methotrexate, and fluorouracil. Docetaxel and cyclophosphamide. Docetaxel, doxorubicin, and cyclophosphamide Cyclophosphamide, epirubicin, and fluorouracil ... more details
Oxaliplatin is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX ... 9704726 ref It has been extensively studied in combination with Fluorouracil and Folinic Acid a combination known as FOLFOX . When compared with Fluorouracil and Folinic Acid administered according ... et al. year 2000 title Leucovorin and fluorouracil with or without oxaliplatin as first line treatment ..., chemotherapy based on Fluorouracil and folinic acid reduces the risk of relapse. The benefit is clinically ... more details
S, Kolder H, Carney B, Phelps C, et al. Five year follow up of the fluorouracil filtering surgery study. American Journal of Ophthalmology 1996 121 4 349 366. Fluorouracil Filtering Surgery Study Group, Alward WLM, Farrell T, Hayreh S, Kolder H, Carney B, et al. Three Year Follow Up of the Fluorouracil ... more details
BLP refimprove date October 2010 File Nci vol 2727 300 Vincent DeVita.jpg thumb Dr. Vincent T. DeVita, Jr. Mike Mitchell photographer Mike Mitchell ,1999 Vincent T. DeVita, Jr. , MD is an internationally recognized pioneer physician in the field of oncology . DeVita earned his Bachelor of Science degree from the College of William and Mary in 1957. He was awarded his Doctor of Medicine MD degree with distinction from the George Washington University School of Medicine in 1961. ref name award 12 June 2007 http www.webwire.com ViewPressRel.asp?aId 39098 Vincent T. DeVita, Jr., MD Honored by ASCO , Webwire press release , Retrieved October 28, 2010 ref DeVita spent the early part of his career at the National Cancer Institute NCI . In 1980, the president of the United States appointed him as director of the NCI and the National Cancer Program, ref name cancer1 Greenberg, Daniel S. http www.nejm.org doi pdf 10.1056 NEJM198010233031744 A Conversation with Vincent T. DeVita, Jr., M.D. , The New England Journal of Medicine , 1980 303 1014 1016, Retrieved October 28, 2010 ref a position he held until 1988. While at the NCI, he was instrumental in developing combination chemotherapy programs that ultimately led to an effective regimen of curative chemotherapy for Hodgkin s disease and diffuse large cell lymphoma s. Along with colleagues at the NCI, he developed the four drug combination, known by the acronym MOPP medicine MOPP , which increased the cure rate for patients with advanced Hodgkin s disease from nearly zero to over 70 . In addition, in collaboration with Dr. George Canellos , DeVita developed the combination chemotherapy Cyclophosphamide Methotrexate Fluorouracil CMF , which still remains a useful therapy for breast cancer . DeVita was the Director of Yale Cancer Center from 1993 to 2003. He is currently the chair of the Yale Cancer Center advisory board and is professor of internal medicine and of epidemiology and public health at Yale School of Medicine Yale s ... more details
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