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Encyclopedia results for G protein coupled receptor

G protein coupled receptor





Encyclopedia results for G protein coupled receptor

  1. G protein-coupled receptor

    structure of a G protein coupled receptor G protein coupled receptors GPCRs , also known as seven ... AJ title International Union of Pharmacology. XLVI. G protein coupled receptor list journal Pharmacol ... journal title The G protein coupled receptor repertoires of human and mouse author Vassilatis DK, Hohmann ... for predicting G protein coupled receptor functional classes url http icpr.jci.jx.cn bioinfo GPCR ... Qiu JD, Huang JH, Liang RP, Lu XQ title Prediction of G protein coupled receptor classes based on the concept ... of G Protein Coupled Receptor Classes in Low Homology Using Chou s pseudo amino acid composition ... title Crystal structure of rhodopsin A G protein coupled receptor journal Science volume 289 issue 5480 ... structure of an engineered human sub 2 sub adrenergic G protein coupled receptor journal Science ... of G protein coupled receptor signals journal J. Cell. Sci. volume 115 issue Pt 3 pages 455 ... RP, Newton CL title The year in G protein coupled receptor research journal Mol. Endocrinol. volume ... termination. GPCR signaling Image GPCR mechanism.png right thumb 300px G protein coupled receptor ... arrs , G protein coupled receptor kinase GRKs , and Src gene Srcs . Additionally, further ... JY, Haastert PV, Devreotes PN title Social senses G protein coupled receptor signaling pathways in Dictyostelium ..., Bascands JL, Girolami JP title A novel protein protein interaction between a G protein coupled receptor ... JA, Lefkowitz RJ title The role of sequestration in G protein coupled receptor resensitization ... conformation conformation allows recruitment of G protein coupled receptor kinase GPCR Regulating ... pathways and, ultimately, cellular responses. G protein coupled receptors are found only in eukaryote ... in size from small molecules to peptide s to large protein s. G protein coupled receptors are involved ... nrd2199 url ref There are two principal signal transduction pathways involving the G protein coupled ... TK, Findlay JB title Fingerprinting G protein coupled receptors journal Protein Eng year 1994 volume ...   more details



  1. G protein-coupled receptor kinase

    enzyme Name G protein coupled receptor kinase EC number 2.7.11.16 CAS number IUBMB EC number 2 7 11 16 GO code 0004703 image Gprotein coupled receptor kinase.png width caption Crystal structure of G protein ... month May pmid 18339619 pmc 2376226 doi 10.1074 jbc.M708974200 url issn ref G protein coupled receptor ... Gene OMIM G protein coupled receptor kinase 1 Rhodopsin kinase Gene GRK1 OMIM2 180381 G protein coupled ... ADRBK1 GRK2 OMIM2 109635 G protein coupled receptor kinase 3 beta adrenergic receptor kinase &beta Adrenergic receptor kinase 2 BARK2 Gene ADRBK2 GRK3 OMIM2 109636 G protein coupled receptor kinase 4 Has been associated with regulation of kidney tubule function Gene GRK4 OMIM2 137026 G protein coupled ... 600870 G protein coupled receptor kinase 6 Knockout mice are supersensitive to dopaminergic s ref ... supersensitivity in G protein coupled receptor kinase 6 deficient mice journal Neuron journal Neuron ... GRK6 OMIM2 600869 G protein coupled receptor kinase 7 Cone opsin kinase Gene GRK7 OMIM2 606987 See also Downregulation and upregulation G protein coupled receptor Phosphorylation Protein kinase References ... Mechanisms of Regulation and Function of G Protein Coupled Receptor Kinases language Polish journal ... The G protein coupled receptor kinase GRK interactome role of GRKs in GPCR regulation and signaling ... Devi LA others title The G Protein Coupled Receptors Handbook Contemporary Clinical Neuroscience chapter G Protein Coupled Receptor Kinases chapterurl http books.google.com books?id sW2SY9zzydMC&pg ... of rhodopsin kinase in different ligand states reveal key elements involved in G protein coupled ... of G protein coupled receptors GPCRs by phosphorylation phosphorylating their intracellular domains ... and deactivation. Defects in GRK1 result in Oguchi disease 2. ref cite web title GRK1 G protein coupled ... H others title G protein coupled receptors chapter G Protein Coupled Kinases and Desensitization ... transferase stub fi Gprk2 sr G protein spregnuti receptor kinaza ...   more details



  1. G protein-coupled receptor kinase 7

    protein Name G protein coupled receptor kinase 7 caption image width HGNCid 17031 Symbol GRK7 AltSymbols GPRK7 EntrezGene 131890 OMIM 606987 RefSeq NM 139209 UniProt Q8WTQ7 PDB ECnumber 2.7.11.14 Chromosome 3 Arm q Band 24 LocusSupplementaryData G protein coupled receptor kinase 7 also known as GRK7 is an enzyme which in humans is encoded by the GRK7 gene . ref name pmid11717351 cite journal author Weiss ER, Ducceschi MH, Horner TJ, Li A, Craft CM, Osawa S title Species specific differences in expression of G protein coupled receptor kinase GRK 7 and GRK1 in mammalian cone photoreceptor cells implications for cone cell phototransduction journal J. Neurosci. volume 21 issue 23 pages 9175 84 year 2001 month December pmid 11717351 doi url ref ref name pmid11754336 cite journal author Chen CK, Zhang K, Church Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W title Characterization of human GRK7 as a potential cone opsin kinase journal Mol. Vis. volume 7 issue pages 305 13 year 2001 month December pmid 11754336 doi url ref ref name entrez cite web title Entrez Gene GPRK7 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 131890 accessdate ref Function This gene encodes a member of the G protein coupled receptor kinase subfamily of the Ser Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylation phosphorylate cone opsin s and initiate their deactivation. ref name entrez References Reflist NLM content gene 3 stub ...   more details



  1. G protein-coupled bile acid receptor

    PBB geneid 151306 The G protein coupled bile acid receptor is a G protein coupled receptor which binds .... Alternative splicing results in multiple transcript variants encoding the same protein. ref name entrez cite web title Entrez Gene GPBAR1 G protein coupled bile acid receptor 1 url http www.ncbi.nlm.nih.gov ... S, Haga T, et al. title Identification of G protein coupled receptor genes from the human genome ... Kawamata Y, Fujii R, Hosoya M, et al. title A G protein coupled receptor responsive to bile acids ... Thomas SM, Bhola NE, Zhang Q, et al. title Cross talk between G protein coupled receptor and epidermal ... Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the G protein coupled receptor GPCR superfamily. This protein functions as a cell surface receptor for bile acids. Treatment ... cite journal author Keitel V, Reinehr R, Gatsios P, et al. title The G protein coupled ... quote MeshName GPBAR1 protein, human G protein coupled receptors transmembranereceptor stub NLM content Category G protein coupled receptors The PBB Controls template provides controls for Protein ... H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M title A G protein coupled receptor responsive to bile acids journal J. Biol. Chem. volume 278 issue 11 pages 9435 40 year 2003 pmid 12524422 doi 10.1074 jbc.M209706200 ref One effect of this receptor is to activate ... growth factor receptor and mitogen activated protein kinases in gastric carcinoma cells. journal ... inspection no update protein box yes update summary yes update citations yes sr Receptor u ne kiseline ... T sub 3 sub . T sub 3 sub in turn activates the thyroid hormone receptor which increases metabolic ... of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated ... of membrane type receptor for bile acids M BAR . journal Biochem. Biophys. Res. Commun. volume ...   more details



  1. Retinal G protein coupled receptor

    PBB geneid 5995 RPE retinal G protein coupled receptor is a protein that in humans is encoded by the RGR ... web title Entrez Gene RGR retinal G protein coupled receptor url http www.ncbi.nlm.nih.gov sites entrez ... G protein coupled receptor has been shown to Protein protein interaction interact with KIAA1279 . ref ... of retinal g protein coupled receptor opsin journal J. Biol. Chem. volume 276 issue 24 pages ... title Synthesis of the all trans retinal chromophore of retinal G protein coupled receptor opsin in cultured ... Lin MY title Deposition of exon skipping splice isoform of human retinal G protein coupled receptor ... stub NLM content G protein coupled receptors Category G protein coupled receptors The PBB Controls template provides controls for Protein Box Bot, please see Template PBB Controls for details. PBB Controls update page yes require manual inspection no update protein box yes update summary no update citations yes sr Retinalni G protein spregnuti receptor ... maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section ... like receptor subfamily of GPCR . Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein presumably acts as a photoisomerase ... cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal ... 2005 month Oct. title Towards a proteome scale map of the human protein protein interaction network ... protein journal Exp. Eye Res. volume 60 issue 4 pages 401 6 year 1995 pmid 7789419 doi 10.1016 S0014 ... A human opsin related gene that encodes a retinaldehyde binding protein journal Biochemistry volume ... first4 Russell G last5 Hankins first5 Mark W last6 Gregory Evans first6 Kevin last7 Gregory Evans ... first5 LH last6 Schuler first6 G last7 Klein first7 SL last8 Old first8 S last9 Rasooly first9 R cite journal author Rual JF title Towards a proteome scale map of the human protein protein interaction ...   more details



  1. Retinoic acid-inducible orphan G protein-coupled receptor

    protein Name GPRC5A G protein coupled receptor, family C, group 5, member A caption image width HGNCid 9836 Symbol GPRC5A AltSymbols RAIG1, RAI3 EntrezGene 9052 OMIM 604138 RefSeq NM 003979 UniProt Q8NFJ5 PDB ECnumber Chromosome 12 Arm p Band 13 LocusSupplementaryData p12.3 protein Name GPRC5B G protein coupled receptor, family C, group 5, member B caption image width HGNCid 13308 Symbol GPRC5B AltSymbols RAIG2 EntrezGene 51704 OMIM 605948 RefSeq NM 016235 UniProt Q9NZH0 PDB ECnumber Chromosome 16 Arm p Band 12 LocusSupplementaryData protein Name GPRC5C G protein coupled receptor, family C, group 5, member C caption image width HGNCid 13309 Symbol GPRC5C AltSymbols RAIG3 EntrezGene 55890 OMIM 605949 RefSeq NM 022036 UniProt Q9NQ84 PDB ECnumber Chromosome 17 Arm q Band 25 LocusSupplementaryData protein Name GPRC5D G protein coupled receptor, family C, group 5, member D caption image width ... G protein coupled receptor s RAIG are a group of four closely related G protein coupled receptor s whose ... a putative G protein coupled receptor journal J. Biol. Chem. volume 273 issue 52 pages 35008 15 year ... Cloning and characterization of a human orphan family C G protein coupled receptor GPRC5D journal ... acid inducible orphan G protein coupled receptors GPRC5B and GPRC5C journal Genomics volume 67 issue ... acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein coupled receptors and appear to activate the Wnt signaling ... X title Retinoic Acid Inducible G Protein Coupled Receptors Bind to Frizzled Receptors and May Activate ... archivedate quote MeshName GPRC5A protein, human MeshName GPRC5B protein, human MeshName GPRC5C protein, human transmembranereceptor stub G protein coupled receptors Category G protein coupled ... Osborne H, Krogsgaard Larsen P title Sequence and expression pattern of a novel human orphan G protein coupled receptor, GPRC5B, a family C receptor with a short amino terminal domain journal Genomics ...   more details



  1. G protein-coupled receptors database

    multiple issues notability August 2011 primary sources August 2011 self published August 2011 orphan April 2011 infobox biodatabase title GPCRDB logo File Database.png description G protein coupled receptor s. scope organism center Radboud University laboratory author Bas Vroling pmid Vroling & al. 2011 ref name pmid21045054 released 1998 standard format url http www.gpcr.org 7tm download webservice sql sparql webapp standalone license versioning frequency curation bookmark version G protein coupled receptors database GPCRDB is a database of G protein coupled receptor s. ref name pmid21045054 cite journal quotes yes last Vroling first Bas authorlink coauthors Sanders Marijn, Baakman Coos, Borrmann Annika, Verhoeven Stefan, Klomp Jan, Oliveira Laerte, de Vlieg Jacob, Vriend Gert year 2011 month Jan title GPCRDB information system for G protein coupled receptors journal Nucleic Acids Res. volume 39 issue Database issue pages D309 19 publisher location England issn pmid 21045054 doi 10.1093 nar gkq1009 bibcode oclc id url pmc 3013641 language eng format accessdate laysummary laysource laydate quote ref See also G protein coupled receptor s References references External links http www.gpcr.org 7tm . Category Biological databases Category G protein coupled receptors Biodatabase stub ...   more details



  1. Proton-sensing G protein-coupled receptors

    pmid 17118800 doi 10.1080 10799890600932220 url issn ref These G protein coupled receptor s are activated ... G protein coupled receptor 1 gene OGR1 had slower melanoma growth KO than control mice with OGR1 ... Deficient for Ovarian Cancer G Protein Coupled Receptor 1 journal PLoS ONE volume 4 issue 5 pages ... 7.0 . The functional role of the low pH sensitivity of the proton sensing G protein coupled ... bone and Inflammation inflamed tissues. The four known proton sensing G protein coupled receptors are Rhodopsin ... G protein coupled receptors have been shown to be expressed in small diameter neurons responsible ... root ganglion express proton sensing G protein coupled receptors journal Mol. Cell. Neurosci. volume ... role for proton sensing GPCRs in osteoclast s. References reflist Category G protein coupled receptors G protein coupled receptors sr Proton indiciraju i G protein spregnuti receptori ... Li H, Wang D, Singh LS, Berk M, Tan H, Zhao Z, Steinmetz R, Kirmani K, Wei G, Xu Y editor1 last ...   more details



  1. G protein-coupled inwardly-rectifying potassium channel

    biochemistry ligand stimulated G protein coupled receptor s GPCRs . ref name pmid9429760 cite journal author Dascal N title Signalling via the G protein activated K sup sup channels journal Cell ... The G protein coupled inwardly rectifying potassium channels GIRKs are a family of inward rectifier ... ir sub 3.4 Examples A wide variety of G protein coupled receptors activate GIRKs, including the muscarinic ... 1998 pmid 9478984 doi 10.1074 jbc.273.9.5271 ref References Reflist 2 External links MeshName G Protein Coupled Inwardly Rectifying Potassium Channels Ion channels g3 Category Ion channels sr G protein ... ref name pmid9860808 cite journal author Yamada M, Inanobe A, Kurachi Y title G protein regulation ... ref GPCRs in turn release activated G protein G protein subunits G beta gamma subunits Beta gamma complex G sub sub from inactive heterotrimeric G protein complexes G sub sub . Finally, the G sub sub dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell. G protein coupled inwardly rectifying potassium channels are a type of G protein gated ion channel s because of this direct activation of GIRK channels by G protein subunits. GIRK1 to GIRK3 are distributed broadly in the central nervous ... T, Ikeda K, Ichikawa T, Abe S, Togashi S, Kumanishi T title Molecular cloning of a mouse G protein ... Krapivinsky G, Gordon EA, Wickman K, Velimirovi B, Krapivinsky L, Clapham DE title The G protein gated ... Identification of domains conferring G protein regulation on inward rectifier potassium channels journal ... I, Clapham DE title Structure, G protein activation, and functional relevance of the cardiac G ... title The G protein gated atrial K sup sup channel I sub KACh sub is a heteromultimer of two inwardly ... G, Krapivinsky L, Clapham DE title Number and stoichiometry of subunits in the native atrial G protein ...protein Name KCNJ3 potassium inwardly rectifying channel, subfamily J, member 3 caption image width HGNCid ...   more details



  1. Guanylate cyclase-coupled receptor

    Guanylate cyclase coupled receptor or Membrane bound guanylyl cyclase is a single transmembrane protein. ref name SiegelAlbers2006 cite book author1 George J. Siegel author2 R. Wayne Albers title Basic neurochemistry molecular, cellular, and medical aspects url http books.google.com books?id Af0IyHtGCMUC&pg PA368 accessdate 16 December 2010 year 2006 publisher Academic Press isbn 9780120883974 pages 368 ref They are enzyme linked receptor s GC A NPR1 GUCY2A & GC B NPR2 GUCY2B for natriuretic factor s such as atrial natriuretic factor ANF . GC C guanylyl cyclase c GUCY2C for guanylin and uroguanylin . GC D GUCY2D GC E GUCY2E GC F GUCY2F There is also a human pseudogene for GUCY2GP . References reflist External links MeshName Guanylate Cyclase Coupled Receptors Enzyme linked receptors Phosphorus oxygen lyases DEFAULTSORT Guanylate Cyclase Coupled Receptor Category EC 4.6.1 ...   more details



  1. G protein

    accessdate ref G protein coupled receptor s are transmembrane receptors. Signal molecules bind to a domain located outside the cell. An intracellular domain activates a G protein. The G protein activates ... transducing molecules in cells. Malfunction of GPCR G Protein Coupled Receptor signaling pathways ... change in the G protein coupled receptor , exchange GDP for GTP, and dissociate to activate other ... activates the G protein coupled receptor , it induces a conformational change in the receptor that allows ... enzymes directly. Instead, the receptor stimulates a G protein, which stimulates an enzyme ... None ref The human genome encodes roughly 950 G protein coupled receptors , which detect photons .... Common mechanism Image GPCR Zyklus.png thumb 300px Activation cycle of G proteins by G protein coupled receptors Receptor activated G proteins are bound to the inside surface of the cell membrane ... to and activating G protein coupled inwardly rectifying potassium channel s. Small GTPases Main Small ...distinguish Protein G Merge Heterotrimeric G protein date June 2011 Image 1b9x opm.gif thumb 250px Phosducin transducin beta gamma complex. Beta and gamma subunits of G protein are shown by blue and red ... abstract 296 5573 1636 title G Protein Pathways Neves et al. 296 5573 1636 Science date 31 May 2002 ... found in the human genome have unknown functions. Types of G protein signaling G protein can refer to two distinct families of proteins. Heterotrimeric G protein s, sometimes referred to as the large G proteins that are activated by G protein coupled receptor s and made up of alpha , beta , and gamma Protein subunit subunit s. There are also small G proteins 20 25kDa that belong to the Ras ... on the G sub sub subunit. In the traditional view of heterotrimeric protein activation, this exchange ... Digby GJ, Lober RM, Sethi PR, Lambert NA. title Some G protein heterotrimers physically dissociate ... K, Lattanzi G, Carloni P title G protein inactive and active forms investigated by simulation ...   more details



  1. Protein A/G

    Protein A G is a fusion protein Recombinant fusion proteins recombinant fusion protein that combines Immunoglobulin G IgG binding domains of both Protein A and Protein G . Protein A G contains four Fc binding domains from Protein A and two from Protein G, yielding a final mass of 50,460 daltons. The binding of Protein A G is less dependent upon pH than Protein A, but otherwise has the additive properties of Protein A and G. Protein A G binds to all subclasses of human IgG, making it useful for purifying polyclonal antibodies polyclonal or monoclonal antibodies monoclonal IgG antibody antibodies whose subclasses have not been determined. In addition, it binds to Immunoglobulin A IgA , Immunoglobulin E IgE , Immunoglobulin M IgM and to a lesser extent Immunoglobulin D IgD . Protein A G also binds to all subclasses of mouse IgG but does not bind mouse IgA, IgM or serum albumin. ref Sikkema, J.W.D. 1989 Amer. Biotech. Lab, 7, 42. ref This allows Protein A G to be used for purification and detection of mouse monoclonal IgG antibodies, without interference from IgA, IgM and serum albumin . Mouse monoclonal antibodies commonly have a stronger affinity to the Chimera protein chimeric Protein A G than to either Protein A or Protein G. ref Eliasson, M., et al. 1988 J. Biol. Chem. 263, 4323 4327. ref Protein A G also has been used for purification of macaque IgG ref Chackerian, B., et al. 2004 J. Virol. 78, 4037 4047. ref Other antibody binding proteins In addition to Protein A G, other immunoglobulin binding Bacteria bacterial proteins such as Protein A , Protein G and Protein L are all commonly used to purify, immobilize or detect antibody immunoglobulins . Each of these immunoglobulin binding proteins has a different antibody binding profile in terms of the portion of the antibody that is recognized and the species and type of antibodies. References references Category Proteins ...   more details



  1. Protein G

    distinguish G protein Protein G is an immunoglobulin binding protein expressed in group C and G Streptococcal bacteria much like Protein A but with differing specificities. It is a 65 kDa G148 protein G and a 58 kDa C40 protein G ref name Sjobring 1991 cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from Recombinant DNA recombinant forms of Protein G. Other antibody binding proteins In addition to Protein G, other immunoglobulin binding bacterial proteins such as Protein A , Protein A G and Protein L are all commonly used to purify, immobilize or detect immunoglobulins. Each of these immunoglobulin binding proteins has a different antibody binding profile in terms of the portion of the antibody that is recognized and the species and type of antibodies it will bind. Folding of Protein G, B1 Domain An Ab initio quantum chemistry methods ab initio simulation of the protein G B1 domain demonstrates that, as earlier results suggested, this protein initiates folding via a nucleation event in the hydrophobe hydrophobic core Amino acid residues followed by small adjustments. ref name Kmiecik 1994 The folding events are as follows a Beta hairpin hairpin is formed, stabilized by residues W43, Y45, and F52. Residue contacts between residue F30, in an Alpha helix helix ... in a globular protein . The protein G B1 domain is aka. GB1 often used as part of a fusion protein ... L, Kastern W, et al title Streptococcal protein G. Gene structure and protein binding properties journal ... cite journal author Kmiecik S, Kolinski A title Folding pathway of the b1 domain of protein G explored ... Category Proteins de Protein G es Prote na G Streptococcus ru G ... Yuan Cheng, Dinshaw J Patel, An efficient system for small protein expression and refolding, Biochemical ...   more details



  1. Receptor activity-modifying protein

    p12 Receptor activity modifying proteins RAMP s are a class of protein which interact with and modulate the activities of several Class B GPCR G Protein Coupled Receptor s including the receptors for secretin receptor secretin , calcitonin receptor calcitonin CT , glucagon receptor glucagon , and vasoactive intestinal peptide receptor vasoactive intestinal peptide VIP . ref name Sexton cite journal author Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A title Complexing receptor pharmacology modulation of family B G protein coupled receptor function ...protein Name Receptor activity modifying protein 1 caption image width 500px HGNCid 9843 Symbol RAMP1 ... q Band 36 LocusSupplementaryData 37.1 protein Name Receptor activity modifying protein 2 caption ... O60895 PDB ECnumber Chromosome 17 Arm q Band 12 LocusSupplementaryData 21.1 protein Name Receptor activity modifying protein 3 caption image width HGNCid 9845 Symbol RAMP3 AltSymbols EntrezGene 10268 ... archiveurl archivedate quote MeshName Receptor activity modifying protein Neuropeptide receptors ... and Pharmacology Chapter 3 Receptor pharmacology journal Advances in Pharmacology volume 52 issue ... is divided into classes activities. When associated with the Calcitonin receptor CTR or CALCRL Calcitonin receptor like CALCRL below RAMPs can change the selectivity of the receptor for a specific ... to AM KO mice. Types Association of RAMPs with either the calcitonin receptor CT or CALCRL proteins form 6 different receptors from the calcitonin receptor family ref name IUPHAR DB cite web url ... specificity of the calcitonin receptor like receptor journal Nature volume 393 issue 6683 pages 333 ... resultant receptor rowspan 3 CALCRL Calcitonin receptor like RAMP1 CGRP RAMP2 adrenomedullin AM receptor, designated AM sub 1 sub ref name pmid10217420 cite journal author Kamitani S, Asakawa M, Shimekake ... receptor in human endothelial and vascular smooth muscle cells journal FEBS Lett. volume 448 issue ...   more details



  1. Lipoprotein receptor-related protein

    Lipoprotein receptor related proteins , low density lipoprotein receptor related proteins HGNC or prolow density lipoprotein receptor related protein UniProt , abbreviated LRP , are a group of protein s. They include LRP1 LRP1B LRP2 megalin LRP3 LRP4 LRP5 LRP6 LRP8 , apolipoprotein e receptor LRP10 LRP11 LRP12 See also LRPAP1 low density lipoprotein receptor related protein associated protein 1 Cell surface receptors Lipoprotein metabolism Category Human proteins ...   more details



  1. Endothelial protein C receptor

    author Biguzzi E, Merati G, Liaw PC, et al. title A 23bp insertion in the endothelial protein C receptor ...PBB geneid 10544 Endothelial protein C receptor EPCR also known as activated protein C receptor APC receptor ... protein C activated protein C receptor journal J Biol Chem volume 269 issue 42 pages 26486 91 year ... cell protein C receptor EPCR journal FEBS Lett volume 458 issue 1 pages 77 80 year 1999 month ... Gene PROCR protein C receptor, endothelial EPCR url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... cluster of differentiation 201 . The protein encoded by this gene is a receptor for activated protein ... web title Entrez Gene PROCR protein C receptor, endothelial EPCR url http www.ncbi.nlm.nih.gov sites ... protein C receptor gene and thrombophilia. journal Thromb. Haemost. volume 98 issue 3 pages 564 ... cite journal author Laszik Z, Mitro A, Taylor FB, et al. title Human protein C receptor is present ... author Ye X, Fukudome K, Tsuneyoshi N, et al. title The endothelial cell protein C receptor EPCR functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries ... protein C receptor EPCR gene comparison with the structure of CD1 major histocompatibility complex ... of the human endothelial protein C receptor gene. journal Gene volume 238 issue 2 pages 367 73 ... PF, Smirnov MD, Esmon CT title Mechanisms by which soluble endothelial cell protein C receptor modulates ..., Esmon CT title Metalloproteolytic release of endothelial cell protein C receptor. journal J. Biol ... C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand ... of protein C receptor expression in monocytes. journal Br. J. Haematol. volume 115 issue 2 pages ... cell protein C receptor gene in venous thrombophilia. journal Thromb. Haemost. volume 86 issue 6 pages ..., Oganesyan N, Terzyan S, et al. title The crystal structure of the endothelial protein C receptor and a bound ... Activation of endothelial cell protease activated receptor 1 by the protein C pathway. journal Science ...   more details



  1. AH receptor-interacting protein

    PBB geneid 9049 AH receptor interacting protein AIP also known as aryl hydrocarbon receptor interacting protein , immunophilin homolog ARA9 , or HBV X associated protein 2 XAP 2 is a protein that in humans is encoded by the AIP gene . ref name entrez cite web title Entrez Gene AIP aryl hydrocarbon receptor interacting protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... HBV X protein. ref name entrez cite web title Entrez Gene AIP aryl hydrocarbon receptor interacting protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9049 ... protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments ... activated receptor alpha is complexed with the 90 kDa heat shock protein and the hepatitis ..., Whitlock JP title A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide ... B virus X associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex ... al. title Characterization of the Ah receptor associated protein, ARA9. journal J. Biol. Chem. volume ... like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. journal ... like protein XAP2 regulate dioxin receptor function and interaction with hsp90. journal J ... that peroxisome proliferator activated receptor alpha is complexed with the 90 kDa heat shock protein ... C, Yang WM, Seto E title XAP2, a novel hepatitis B virus X associated protein that inhibits X transactivation ... Carver LA, Bradfield CA title Ligand dependent interaction of the aryl hydrocarbon receptor with a novel ... role in aryl hydrocarbon receptor mediated signalling possibly by influencing its receptivity for ligand ... patients. ref name pmid20530095 cite journal author Occhi G, Trivellin G, Ceccato F, et al. title ... online.org content 163 3 369.long ref Interactions AIP has been shown to Protein protein interaction interact with the aryl hydrocarbon receptor , ref name pmid9111057 ref name pmid10986286 cite journal ...   more details



  1. LDL-receptor-related protein associated protein

    lipoprotein receptor related protein associated protein 1 also known as LRPAP1 or RAP is a chaperone ... Primary structure of alpha 2 macroglobulin receptor associated protein. Human homologue of a Heymann ... Entrez Gene LRPAP1 low density lipoprotein receptor related protein associated protein 1 url http www.ncbi.nlm.nih.gov ... the Binding molecular binding of all know ligands for these receptors, and may prevent receptor protein ... macroglobulin receptor associated protein journal Proc. Natl. Acad. Sci. U.S.A. volume 94 issue 14 pages ... coauthors Farquhar M G year 1994 month Apr. title Functional domains of the receptor associated ... the activity of alpha 2 macroglobulin receptor low density lipoprotein receptor related protein. Multiple regulatory sites for 39 kDa receptor associated protein. journal J. Biol. Chem. volume 267 ... DK title The 39 kDa receptor associated protein interacts with two members of the low density ... al. title 39 kDa protein modulates binding of ligands to low density lipoprotein receptor related protein alpha 2 macroglobulin receptor. journal J. Biol. Chem. volume 266 issue 31 pages 21232 8 year ... receptor gene family, gp330 and LRP alpha 2MR, and the receptor associated protein RAP . journal ... Orlando RA, Farquhar MG title Functional domains of the receptor associated protein RAP . journal ... 2 macroglobulin receptor associated protein 1 gene LRPAP1 and other gene fragments to human chromosome ... HJ, Strous GJ, Schwartz AL title 39 kDa receptor associated protein is an ER resident protein and molecular chaperone for LDL receptor related protein. journal EMBO J. volume 14 issue 10 pages 2269 ... coding for the alpha 2 macroglobulin receptor associated protein and structural comparison with the murine ... GL, Bowen SL, et al. title The 39 kDa receptor associated protein modulates lipoprotein catabolism ... that binds the alpha2 macroglobulin receptor associated protein. journal J. Biol. Chem. volume ... Bu G, Rennke S, Geuze HJ title ERD2 proteins mediate ER retention of the HNEL signal of LRP s receptor ...   more details



  1. CAMP receptor protein

    Lowercase Protein Name CAMP receptor protein image 1i5z.jpg caption Structure of the E. coli Cyclic AMP Receptor Protein. Symbol CRP AltSymbols CAP EntrezGene 947867 RefSeq NP 417816.1 UniProt P0ACJ8 PDB 1I5Z cAMP receptor protein CRP also known as catabolite activator protein , CAP is a regulatory protein in bacteria . CRP protein binds cyclic adenosine monophosphate cAMP , which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the Promoter biology promoter s of the genes it controls ref name Busby cite journal author Busby S., Richard H. Ebright Ebright RH. title Transcription activation by catabolite activator protein CAP journal J. Mol. Biol. volume 293 pages 199 213 year 2001 pmid 10550204 doi 10.1006 jmbi.1999.3161 ref ref name Lawson cite journal author Lawson C.L., Swigon D., Murakami K.S., Darst S.A., Berman H.M., Richard H. Ebright Ebright RH. title Catabolite activator protein DNA binding and transcription activation journal Curr. Opin. Struct. Biol. volume 14 pages 10 20 year 2004 pmid 15102444 doi 10.1016 j.sbi.2004.01.012 ref CRP then activates transcription through direct protein protein interactions with RNA polymerase . ref name Busby ref name Lawson The genes regulated by CRP are mostly involved in energy metabolism, such as galactose , citrate , or the PEP group translocation system. ref cite journal author Weickert MJ, Adhya ... coli, cyclic AMP receptor protein CRP can regulate the transcription of more than 100 genes. The signal ..., in which protein protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter. ref name Busby References Reflist DEFAULTSORT cAMP Receptor Protein Category ... signal transduction from the N terminal cAMP binding domain to the C terminal domain of the protein ... and activates transcription through protein protein interactions between activating region 1 of CRP ... 35 element and activates transcription through two sets of protein protein interactions 1 an interaction ...   more details



  1. Heterotrimeric G protein

    hand, directly open Inward rectifier potassium ion channel G protein coupled inward rectifying potassium ...Merge G protein date June 2011 Image G protein1.png thumb This heterotrimeric G protein is illustrated .... Image G Protein.png thumb 3D structure of a heterotrimeric G protein G protein usually refers to the membrane associated heterotrimeric G proteins , sometimes referred to as the large G proteins . These proteins are activated by G protein coupled receptor s and are made up of alpha , beta and gamma Protein subunit subunit s, ref name Hurowitz 2000 cite journal author Hurowitz EH, Melnyk ... G protein alpha, beta, and gamma subunit genes journal DNA Res volume 7 issue 2 pages 111 ... subunit of the stimulatory G protein G sub s sub activates hormone sensitive adenylate cyclase ... receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved ... G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits journal Proc. Natl ... pmc 51921 ref border 1 cellspacing 0 bgcolor cfcfcf width 10 G protein family bgcolor cfcfcf ... cyclase olfactory receptor s Smell bgcolor dfdfdf colspan 5 G sub q sub family G sub q sub Gq alpha ... G proteins Category Membrane biology Category Peripheral membrane proteins de Heterotrimeres G Protein fr Prot ine h t rotrim rique sr Heterotrimerni G protein ... G sub sub subunits can directly activate effector enzymes. The GTP form of the subunit of transducin G sub t sub activates the cyclic GMP phosphodiesterase from retinal rod outer segments, ref ... proteins. J. Biol. Chem. 260 15829 15833. PMID 2999139. ref G sub sub subunits consist of two ... G sub sub subunits, which are separated into four main families. This nomenclature is based ... G sub i sub family G sub i o sub Gi alpha subunit sub i sub , sub o sub GNAO1 , GNAI1 , GNAI2 ... receptor sub 2 sub Adrenoreceptors , Serotonin 5 HT sub 1 sub receptors, Histamine H sub 3 sub ...   more details



  1. Regulator of G protein signalling

    G proteins, thereby inactivating the G protein and rapidly switching off G protein coupled receptor signalling pathways ref name PUB00006536 cite journal author De Vries L, Farquhar MG, Zheng B, Fischer T, Elenko E title The regulator of G protein signaling family journal Annu. Rev. Pharmacol ...Pfam box Symbol RGS Name Regulator of G protein signalling domain image PDB 1gia EBI.jpg width caption ... D 54 174 PDB3 1omw A 54 174 PDB3 2bcj A 54 174 Regulators of G protein signalling or RGS are protein structural domain s that activate GTPase s for heterotrimeric G protein alpha subunits. RGS are multi ... by stabilising the G protein transition state. All RGS proteins contain an RGS box or RGS domain , which ... PUB00015163 cite journal author Burchett SA title Regulators of G protein signaling a bestiary of modular ... , and GGL domain GGL G protein gamma subunit like for binding G protein beta subunits InterPro IPR001770 ref name PUB00015162 cite journal author Dohlman HG, Chasse SA title RGS proteins G protein ... can interact with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit association, thereby preventing heterotrimer formation. Examples ... Inhibition of G protein signaling by dominant gain of function mutations in Sst2p, a pheromone ... G protein alpha subunits journal Nature volume 383 issue 6596 pages 172 5 year 1996 month September ... AG title GAIP and RGS4 are GTPase activating proteins for the Gi subfamily of G protein alpha subunits ..., a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein ... in PROSITE GTP binding protein regulators Category G proteins Category Protein domains Category Peripheral membrane proteins sr Regulator G protein signalizacije vi Ch t i u ti t truy n t n hi u protein ... SMART RGS PROSITE PDOC50132 SCOP 1gia TCDB OPM family OPM protein 2bcj PDB PDB3 2af0 A 83 198 ... ref . Upon activation by GPCRs, heterotrimeric G proteins exchange GDP for GTP, are released ...   more details



  1. Rab (G-protein)

    The Rab family of protein s is a member of the Ras superfamily of monomer ic G proteins . ref name pmid11387043 cite journal author Stenmark H, Olkkonen VM title The Rab GTPase family journal Genome Biol. volume 2 issue 5 pages REVIEWS3007 year 2001 pmid 11387043 pmc 138937 doi 10.1186 gb 2001 2 5 reviews3007 url http genomebiology.com content 2 5 REVIEWS3007 ref Approximately 70 types of Rabs have now been identified in humans. Rab GTPases regulate many steps of membrane traffic, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside the cell, such as the transferrin receptor, or serves as a means of regulating the number of a certain type of protein molecules on the surface. Function Rab proteins are peripheral membrane proteins, anchored to a membrane via a lipid group covalently linked to an amino acid. Specifically, Rabs are anchored via prenyl groups on two cysteine s in the C terminus. Rab escort proteins REPs deliver newly synthesized and prenylated Rab to its destination membrane by binding the hydrophobic , insoluble prenyl groups and carrying Rab through the cytoplasm. The lipid prenyl group s can then insert into the membrane, anchoring Rab at the cytoplasmic face of a vesicle or the plasma membrane. Because Rab proteins are anchored to the membrane through ... links MeshName rab G Proteins GTPases Vesicular transport proteins Intracellular signaling peptides and proteins Category G proteins Category Peripheral membrane proteins ca Prote na Rab cs Rab G protein ... to GDP is catalyzed by a GTPase activating protein GAP . REPs carry only the GDP bound form ... Rab to its original membrane. Clinical significance Defects in protein prenylation can cause pathologies ...   more details



  1. Receptor protein serine/threonine kinase

    enzyme Name Receptor protein serine threonine kinase EC number 2.7.11.30 CAS number 146702 86 5 IUBMB EC number 2 7 11 30 GO code image width caption In enzymology , a receptor protein serine threonine kinase EC number 2.7.11.30 is an enzyme that catalysis catalyzes the chemical reaction ATP receptor protein math rightleftharpoons math ADP receptor protein phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and receptor protein , whereas its two product chemistry products are adenosine diphosphate ADP and receptor protein phosphate . This enzyme belongs to the family of transferase s, to be specific those transferring phosphorus containing groups protein serine threonine kinases. The systematic name of this enzyme class is ATP receptor protein phosphotransferase . Other names in common use include activin receptor kinase , receptor type I serine threonine protein kinase , receptor type II serine threonine protein kinase , STK13 , TGF beta kinase , and receptor serine threonine protein kinase . This enzyme participates in 7 metabolism metabolic pathways mapk signaling pathway , cytokine cytokine receptor interaction , tgf beta signaling pathway , adherens junction , colorectal cancer , pancreatic cancer , and chronic myeloid leukemia . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2GOO , PDB link 2H62 , PDB link 2H64 , PDB link 2HLQ , and PDB link 2HLR . References reflist 1 refbegin cite journal author Wrana JL, Attisano L, Wieser R, Ventura F, Massague J date 1994 title Mechanism of activation of the TGF beta receptor journal Nature. volume 370 pages 341&ndash 7 pmid 8047140 doi 10.1038 370341a0 issue 6488 cite journal author Massague J, Chen YG date 2000 title Controlling TGF beta signaling journal Genes ... enzyme stub Serine threonine specific protein kinases Enzyme linked receptors Category EC 2.7.11 ...   more details



  1. Outer membrane protein G

    Pfam box Symbol Porin OmpG Name Outer membrane protein G OmpG image 2iwv.gif width 220 caption Pfam PF09381 InterPro SMART Prosite SCOP 2iwv TCDB 1.B.21 OPM family 181 OPM protein 2iwv PDB Outer membrane protein G OmpG is a porin protein porin , a channel proteins in the Bacterial outer membrane outer membrane of Gram negative bacteria . Escherichia coli OmpG forms a 14 stranded beta barrel and in contrast to most porins, appears to function as a monomer. ref name pmid16797588 cite journal author Subbarao GV, van den Berg B title Crystal structure of the monomeric porin OmpG journal J. Mol. Biol. volume 360 issue 4 pages 750 9 year 2006 month July pmid 16797588 doi 10.1016 j.jmb.2006.05.045 url ref The central pore of OmpG is wider than other E. coli porins and it is speculated that it may form a non specific channel for the transport of larger oligosaccharide s. ref name pmid16797588 cite journal author Subbarao GV, van den Berg B title Crystal structure of the monomeric porin OmpG journal J. Mol. Biol. volume 360 issue 4 pages 750 9 year 2006 month July pmid 16797588 doi 10.1016 j.jmb.2006.05.045 url ref References reflist Category Protein domains Category Protein families Category Outer membrane proteins membrane protein stub InterPro content ...   more details



  1. Bone morphogenetic protein receptor, type 1

    Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins . They belong to a class of receptor serine threonine kinases that bind members of the TGF beta superfamily of ligands the Bone morphogenetic protein s. There are two type I BMP receptors BMPR1A and BPMR1B . External links MeshName Bone Morphogenetic Protein Receptors, Type I TGF beta signaling Serine threonine specific protein kinases Growth factor receptors Category Receptors Category Transmembrane receptors Category S T domain Category GS domain Category Bone morphogenetic protein ...   more details




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