Infobox disease Name Glioblastomamultiforme ICD10 ICD10 C 71 c 69 ICD9 ICD9 191 ICDO ICDO 9440 3 Image ... 147 eMedicine mult eMedicine2 med 2692 DiseasesDB 29448 MeshID D005909 Glioblastomamultiforme GBM ... first7 R. A. title GlioblastomaMultiforme Clinical Findings, Magnetic Resonance Imaging, and Pathology ...?citype Disease&ciid Glioblastoma 20multiforme t3 Glioblastomamultiforme at Mount Sinai Hospital ... Li Fraumeni syndrome Turcot syndrome Pathogenesis Glioblastomamultiforme tumors are characterized ... Samuel J. title A multivariate analysis of 416 patients with glioblastomamultiforme prognosis, extent ... GlioblastomaMultiforme Prognostic Factors and Patterns of Progression journal International ... ref Boron neutron capture therapy has been tested as an alternative treatment for glioblastomamultiforme ... for GlioblastomaMultiforme journal Progress in Neurotherapeutics and Neuropsychopharmacology volume ... glioblastomamultiforme GBM and anaplastic astrocytoma. ref http clinicaltrials.gov ct2 show ... report on tumor stem cell B cell hybridoma vaccine for recurrent glioblastomamultiforme journal .... last9 Heese first9 O. title Long term survival with glioblastomamultiforme journal Brain volume ... repair gene MGMT in long term survivors of glioblastomamultiforme journal Journal of Neuro ..., Los Angeles Neuro Oncology How Our Patients Perform GlioblastomaMultiforme GBM& 93 . Neurooncology.ucla.edu. ... tumors. According to a 2003 study, glioblastomamultiforme prognosis can be divided into three subgroups ... partitioning analysis RPA for glioblastomamultiforme GBM patients journal International Journal ... http www.abta.org tumor treatement 81 2 Information about GlioblastomaMultiforme GBM from ... Link GA de Link FA it ca Glioblastomamultiforme de Glioblastom el es Glioblastoma fr Glioblastome multiforme it Glioblastoma la Glioblastomamultiforme ja no Glioblastomamultiforme pl Glejak wielopostaciowy pt Glioblastomamultiforme ru simple Glioblastoma ... more details
Infobox disease Name Erythema multiforme Image EMminor09.JPG Caption Erythema multiforme minor of the hands ... ICDO OMIM MedlinePlus 000851 eMedicineSubj derm eMedicineTopic 137 MeshID D004892 Erythema multiforme ... of life. Presentation The condition varies from a mild, self limited rash erythema multiforme minor E. multiforme minor ref DorlandsDict three 000036713 erythema multiforme ref to a severe, life threatening form known as erythema multiforme major or erythema multiforme majus that also involves ... cite journal author Lamoreux MR, Sternbach MR, Hsu WT title Erythema multiforme journal Am Fam ... days is the norm. Individuals with persistent chronic erythema multiforme will often have a sore form ... recurrent erythema multiforme eruption. ref Tatnall FM et al A double blind plaebo controlled trial of continuous acyclovir therapy in recurrent erythema multiforme. Br J Dermatol 132 267,1995 ref The human form of Orf animal disease orf can also cause erythema multiforme. Citation needed date May 2011 ... , and allopurinol , or a host of internal ailments. Persistent chronic erythema multiforme ... Erythema multiforme is frequently self limiting and requires no treatment. The appropriateness of glucocorticoid ... for erythema multiforme in children journal Can Fam Physician volume 51 issue pages 1481 3 year 2005 ... ref Gallery lines 3 Image Erythema multiforme.jpg Erythema multiforme reaction to an antibiotic Image Steven Johnsons Syndrome.jpg Erythema multiforme major Stevens Johnson syndrome which resembles erythema multiforme Image Target lesion 1.jpg Target lesion File Erythema Multiforme target lesions on the leg, Nell Brigham, 2011.jpg Erythema Multiforme target lesions on the leg See also Erythema multiforme major Erythema multiforme minor Toxic epidermal necrolysis Stevens Johnson syndrome References ... Cutaneous condition stub ar de Erythema exsudativum multiforme es Eritema multiforme fa fr ryth me polymorphe it Eritema multiforme pl Rumie wielopostaciowy ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 L 92 8 l 80 ILDS L92.840 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Granuloma multiforme is a cutaneous condition most commonly seen in central Africa , and rarely elsewhere, characterized by skin lesion s that are on the upper trunk and arms in sun exposed areas. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 707 See also Skin lesion References reflist Cutaneous condition stub Cutaneous ketatosis, ulcer, atrophy, necrobiosis, and vasculitis Category Monocyte and macrophage related cutaneous conditions ... more details
glioblastomamultiforme journal Journal of Neurosurgery volume 101 issue 2 pages 219 ... title Histologic factors of prognostic significance in the glioblastomamultiforme journal Cancer volume ...Infobox name Infobox doc bodystyle above Giant cell glioblastoma abovestyle background lightgrey image ... data2 Giant cell glioblastoma label3 Structure data3 Neuroepithelial tumors br Astrocytic tumors br Glioblastoma br Giant cell glioblastoma header4 International Classification of Diseases for Oncology ... The giant cell glioblastoma is a histological variant of glioblastoma , presenting a prevalence ... chapter Giant cell glioblastoma editor Kleihues P and Cavenee WK title Pathology and Genetics of Tumours ... and sign are similar to those of the ordinary glioblastoma. Methodology of diagnosis and treatment are the same. Prognosis is similar to the ordinary glioblastoma about 12 months . ref name DeAngelis ... annotation The giant cell glioblastoma was originally termed monstrocellular sarcoma , because of its ... date September 2010 ref Epidemiology Incidence The giant cell glioblastoma is a rare neoplasia its incidence ..., ordinary glioblastoma . ref name Palma1989 ref Cite journal author Meyer Puttlitz B, Hayashi ... November pmid 9370234 doi 10.1097 00005072 199711000 00008 issn 0022 3069 ref The giant cell glioblastoma ... with giant cell glioblastoma have unfavourable prognosis, ref Cite journal author Huang MC, Kubo O, Tajika Y, Takakura K title A clinico immunohistochemical study of giant cell glioblastoma journal ... clinical results slightly better than the ordinary glioblastoma, ref Cite journal author Margetts JC, Kalyan Raman UP title Giant celled glioblastoma of brain. A clinico pathological and radiological ... W title Favorable outcome of giant cell glioblastoma in a child. Report of an 11 year survival ..., due to the nature of giant cells of this type. ref name Ohgaki 2000 See also Glioblastoma ... nervous system References Reflist 2 Central nervous system tumors DEFAULTSORT Giant cell Glioblastoma ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICD9 695.11 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Erythema multiforme minor also known as Herpes simplex associated erythema multiforme is a skin condition associated with a preceding herpetic infection, characterized by skin lesion s that begin as sharply marginated, erythematous macule s, which then become raised and develop a target like appearance. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0721629210. ref rp 140 Erythema multiforme minor is sometimes divided into papular and vesiulobullous forms. ref name TrozakTennenhouse2005 cite book author1 Daniel J. Trozak author2 Dan J. Tennenhouse title Dermatology skills for primary care an illustrated guide url http books.google.com books?id hn 5f4KMKW0C&pg PA161 accessdate 5 June 2010 date 1 October 2005 publisher Humana Press isbn 9781588294890 pages 161 ref See also Erythema Diascopy Erythema multiforme List of cutaneous conditions References reflist Cutaneous condition stub Urticaria and erythema Category Erythemas ... more details
Infobox Disease Name Erythema multiforme major Image Confluent epidermal necrosis very high mag.jpg Caption Micrograph of confluent epidermal necrosis. H&E stain . DiseasesDB ICD10 ICD9 ICD9 695.12 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Erythema multiforme major also known as Erythema multiforme minor erythema multiforme von Hebra ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref is a term that may be used to refer to two conditions that constitute a spectrum of the same disease process Stevens Johnson syndrome SJS Toxic epidermal necrolysis TEN The term Erythema multiforme major is sometimes used to imply a bullous presentation. ref name TrozakTennenhouse2005 cite book author1 Daniel J. Trozak author2 Dan J. Tennenhouse title Dermatology skills for primary care an illustrated guide url http books.google.com books?id hn 5f4KMKW0C&pg PA161 accessdate 5 June 2010 date 1 October 2005 publisher Humana Press isbn 9781588294890 pages 161 ref According to some sources, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment. ref name urlErythema Multiforme eMedicine Emergency Medicine cite web url http emedicine.medscape.com article 762333 overview title Erythema Multiforme eMedicine Emergency Medicine format work accessdate ref ref name pmid8420497 cite journal author Bastuji Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC title Clinical classification of cases of toxic epidermal necrolysis, Stevens Johnson syndrome, and erythema multiforme journal Arch Dermatol volume 129 issue 1 pages 92 6 year 1993 month January pmid 8420497 doi 10.1001 archderm.129.1.92 url http archderm.ama assn.org cgi pmidlookup?view long&pmid 8420497 ref Survivors Woodrow Allen Boyer, author, broadcaster, entrepreneur and lecture circuit personality. He survived toxic epidermal ... more details
Radiation induced erythema multiforme may occur when phenytoin is given prophylactically to neurosurgical patients who are receiving whole brain therapy and systemic steroids. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 130 See also Skin lesion References reflist Category Ionizing radiation induced cutaneous conditions Cutaneous condition stub ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 Y40 ICD9 ICD9 E930.8 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Urticarial erythema multiforme is an unusual reaction virtually always associated with antibiotic ingestions, characterized by skin lesions that consist of urticarial papule s and plaques, some of which clear centrally forming annular lesions, but with no true urticarial lesions. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 130 See also Skin lesion List of cutaneous conditions References reflist Cutaneous condition stub External causes of morbidity and mortality Category Drug eruptions ... more details
A glioblast is a type of cell derived from neuroectoderm and with the ability to differentiate into several different types of neuroglia . It is considered by some sources to be equivalent to spongioblast , Citation needed date October 2008 while other sources consider them to be distinct entities. ref eMedicineDictionary glioblast ref ref eMedicineDictionary spongioblast ref See also Glioblastoma multiforme References references Gray s Development of nervous system Human cell types derived primarily from ectoderm Category Embryology of nervous system Anatomy stub fr glioblaste ... more details
Glial tumor is a general term for numerous tumors of the central nervous system , including astrocytomas , ependymal tumor s, glioblastoma multiforme , and primitive neuroectodermal tumor s. External links http www.cancer.gov Templates db alpha.aspx?CdrID 45697 Glial tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Nervous system neoplasia oncology stub ... more details
APG101 ref http apogenix.com ref is for the treatment of Glioblastomamultiforme GBM . APG101 is a soluble CD95 Fc fusion protein for the treatment of malignant diseases. APG101 blocks the CD95 ligand CD95L from binding to the CD95 receptor CD95 . So far, APG101 has been tested in 20 healthy volunteers and 32 patients. It was well tolerated and has shown no serious side effects. ref www.biocentury.com products apg101 ref Currently, APG101 s efficacy is being tested in a clinical phase II study with patients suffering from Glioblastoma. The ongoing study was initiated at the beginning of 2010 and is expected to run through 2011. A total of 83 patients will be enrolled in the trial. At the moment, patient recruitment is still ongoing. ref ClinicalTrials.gov, a service of the U.S. National Institutes of Health, http clinicaltrials.gov ct2 show NCT01071837 ref APG101 constitutes an innovative approach to treating GBM since it has the therapeutic aim to inhibit the invasive growth of glioblastoma cells. This therapy is based on results from the DKFZ German Cancer Research Center DKFZ that in glioblastoma cells, the binding of the CD95 Ligand to its cognate receptor stimulates the invasive growth of the tumor cells. ref Kleber et al Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell, 2008 Mar 13 3 235 48, http www.ncbi.nlm.nih.gov pubmed 18328427 ref Thus, the inhibition of this interaction by APG101 reduces tumor cell migration. An article in Nature ref www.nature.com nature journal v465 n7297 full nature09075.html ref published on 27 May 2010 CD95 promotes tumor growth supports APG101 s principle of inhibiting the CD95 CD95L system in the treatment of tumors. The paper was submitted by Professor Marcus Peter and his team at the University of Chicago. Apogenix has been granted orphan drug status for APG101 to treat GBM in Europe and the US. References references Category Drugs de APG101 ... more details
Unreferenced date March 2007 Orphan date February 2009 A gemistocyte sg. IPAc en icon d m s t s a t respell je MIS t syt is a swollen, reactive astrocyte . These cells usually appear during acute injury after that, they gradually shrink in size. Gemistocytes are also found in some chronic disease s and within certain brain tumors, which suggests the presence of a long lasting pathological reaction. In the context of cancer gemistocytic astrocytomas , gemistocytes are known to dedifferentiate to a high grade III or IV glioma i.e. glioblastoma multiforme at a rapid pace, usually indicative of a poor prognosis . Category Nervous tissue cells Category Central nervous system cell biology stub ... more details
File AFIP 00405558 Glioblastoma Radiology.jpg thumb right MRI showing a ring enhancing lesion in the brain of a patient with glioblastomamultiforme A ring enhancing lesion is an abnormal finding on MRI or CT scan s obtained using radiocontrast . On the image there is an area of decreased density see radiodensity surrounded by a bright rim from concentration of the enhancing contrast dye. This can be a finding in numerous disease states. In the brain, it can occur with an early brain abscess as well as in Nocardia infections associated with lung cavitary lesions. In patients with HIV the major differential is between CNS lymphoma and CNS Toxoplasmosis . External links http medical dictionary.thefreedictionary.com ring enhancement Ring Enhancement The Free Medical Dictionary Category Neuroimaging Category Radiologic signs med sign stub ... more details
unreferenced date February 2012 Infobox film name Juncture image Juncture film.jpg image size alt caption Theatrical release poster director James Seale film director James Seale producer screenplay based on starring Kristine Blackport music cinematography editing studio distributor released October 6, 2007 small worldwide runtime 106 minutes country Film US language English budget gross Juncture is a 2007 thriller film directed by James Seale film director James Seale and the first in a planned trilogy. The plot revolves around the character of Anna Carter Kristine Blackport an ordinary woman who turns into a vigilante . Plot Anna Carter is a woman with a jet setting lifestyle working for business man Jonathan Lamont. When she is diagnosed with a terminal form of Glioblastoma multiforme glioblastoma and given no more than three months she decides to spend her final days hunting criminals that somehow evaded justice. External links imdb title 0765462 Juncture allrovi movie 419824 Juncture rotten tomatoes juncture Juncture Category 2007 films Category American films Category American thriller films Category English language films thriller film stub ... more details
GBM may refer to Medicine Glioblastomamultiforme , a type of brain tumor Glomerular basement membrane , a part of the glomerulus which helps separate urine from blood Other Game Boy Micro , a portable video game system from Nintendo geometric Brownian motion , used in mathematical modelling of some phenomena in financial markets George B. McClellan , a Union general during the American Civil War known for organizing the Army of the Potomac GLAST Burst Monitor, renamed Gamma ray Burst Monitor, an instrument aboard the Fermi Gamma ray Space Telescope Global Banking & Markets , a business in the Royal Bank of Scotland group gradient boosting , a machine learning technique Grand Bauhinia Medal , an honour in Hong Kong Greater Britain Movement , a far right group Isle of Man s List of international license plate codes international vehicle license plate code Great Bowel Movement , a social awareness movement for Crohn s Disease and Colitis disambiguation de GBM es GBM eo GBM fr GBM it GBM pl GBM sv GBM zh GBM ... more details
barelinks date September 2011 Toca 511 & Toca FC Toca 511, the key novel component of Tocagen s ref http www.tocagen.com site c.quIYL6MOJrE b.3789961 k.8FC2 Tocagen Inc.htm ref first Product Candidate Toca 511 & Toca FC ref http www.tocagen.com site c.quIYL6MOJrE b.3791445 k.DFD0 Products.htm ref , was developed using Controlled Active Gene Transfer CAGT technology ref http www.tocagen.com site c.quIYL6MOJrE b.3791437 k.2AB0 Technology.htm ref . The CAGT platform is a Retroviral Replicating Vector RRV that carries the complete complement of viral gene s gag, pol, env which allow viral replication and subsequent delivery of a therapeutic gene throughout a tumor ref http www.nature.com mt journal v12 n5 full mt20051365a.html ref . Toca 511 is intended to be used in combination with Toca FC. Toca FC is a novel extended release tablet containing 5 FC flucytosine . Toca 511 & Toca FC is being investigated in a Phase I II clinical trial for the treatment of recurrent high grade glioma HGG brain cancer , including glioblastoma multiforme GBM ref http www.tocagen.com site c.quIYL6MOJrE b.6116599 k.9D00 Clinical Trials.htm ref . References See http en.wikipedia.org wiki Wikipedia Footnotes on how to create references using ref ref tags which will then appear here automatically Reflist External links http clinicaltrials.gov ct2 show NCT01156584?term Tocagen&rank 1 Categories Category Experimental medical treatments treatment stub molecular biology stub Category Articles created via the Article Wizard ... more details
, also known as glioblastomamultiforme as well as for treating melanoma , a form of skin cancer ... diagnosed glioblastomamultiforme Malignant prolactinoma Structure and mechanism Temozolomide sometimes ... and overall survival in glioblastomamultiforme patients. Side effects The most common non hematological ... resistant glioblastomamultiforme . ref cite journal title Phase II trial of temozolomide plus ... treatment of glioblastomamultiformeglioblastomamultiforme astrocytoma Oligodendroglioma References ... and benefit from temozolomide in glioblastoma journal N. Engl. J. Med. volume 352 issue 10 pages ... versus radiotherapy alone on survival in glioblastoma in a randomised phase III study 5 year analysis ... more details
File PDB 1ttg EBI.jpg thumb The tenth fibronectin type III domain human, PDB 1TTG File PDB 2rhe EBI.jpg thumb Variable domain of an antibody s lambda light chain human, PDB 2RHE Monobodies , also known as adnectins , are genetically engineered protein s that are able to bind to antigen s. Despite their name, they are not structurally related to antibodies , which makes them a type of antibody mimetic . They are being developed by Adnexus , a biotechnology company which has been part of Bristol Myers Squibb since 2007. The monobody angiocept CT 322 , a VEGF receptor receptor antagonist antagonist , has entered Phase II clinical trial s investigating the treatment of glioblastoma in October 2007. ref ClinicalTrialsGov NCT00562419 CT 322 in Treating Patients With Recurrent Glioblastoma Multiforme and Combination Therapy With Irinotecan ref ref name pmid19576999 cite journal author Bloom L, Calabro V title FN3 a new protein scaffold reaches the clinic journal Drug Discov. Today volume 14 issue 19 20 pages 949 55 year 2009 month July pmid 19576999 doi 10.1016 j.drudis.2009.06.007 url http linkinghub.elsevier.com retrieve pii S1359 6446 09 00219 0 ref It is also being studied for the treatment of other types of cancer, such as non small cell lung cancer ref ClinicalTrialsGov NCT00850577 Ph II of a Novel Anti angiogenic Agent in Combination With Chemotherapy for the Treatment of Non Small Cell Lung Cancer ref and colorectal cancer ref ClinicalTrialsGov NCT00851045 Ph II Trial of a Novel Anti angiogenic Agent in Combination With Chemotherapy for the Second line Treatment of Metastatic Colorectal Cancer ref . Structure Monobodies consist of 94 amino acids and have a molecular mass of about 10 kDa , fifteen times smaller than an IgG type antibody and comparable to the size of a single variable domain of an antibody. They are based on the structure of human fibronectin , more specifically on its tenth extracellular Fibronectin type III domain type III domain . This domain has ... more details
Ricardo J. Komotar MD is an assistant professor of clinical neurosurgery in the Department of Neurological Surgery at the University of Miami and serves as the director of surgical neuro oncology at the University of Miami Hospital and co director of surgical neurooncology at the Sylvester Comprehensive Cancer Center and the University of Miami Health Clinics . Dr. Komotar graduated summa cum laude with a B.S. in neuroscience from Duke University , spending a year at Oxford University in England to focus on neuropharmacology. He received his medical degree from the The Johns Hopkins University School of Medicine with highest honors and completed his internship and neurosurgical residency at Columbia University Medical Center The Neurological Institute of New York , followed by a surgical neurooncology fellowship at Memorial Sloan Kettering Cancer Center to specialize in brain tumors. Dr. Komotar s main clinical interests are surgical and radiosurgical treatment of primary and metastatic brain tumors. Author of over 200 scientific articles, book chapters, and invited editorials in peer reviewed journals such as Neurosurgery and the Journal of Neurosurgery , ref cite web title PubMed Works url http www.ncbi.nlm.nih.gov pubmed?term 22Komotar 20RJ 22 5BAuthor 5D ref Dr. Komotar s research interests include clinical trial development and translational science research that is aimed to pioneer new therapies for brain tumors. He has received NIH grants for his research, and is collaborating currently for clinical trials including that for HSPPC 96 for glioblastoma multiforme . ref cite web title HSPPC 96 Vaccine url http clinicaltrials.gov ct2 show NCT00905060?term glioblastoma AND heat shock protein&rank 2 ref He has served on the Executive Committee for the Congress of Neurological Surgeons and the Executive Board for the AANS CNS Joint Section on Tumors. Dr. Komotar is also founder and director of the Annual Neurosurgery Charity Softball Tournament a successful internat ... more details
Infobox Person name Johnny Gunther imagesize 175px caption birth date November 4, 1929 birth place Paris , France death date death date and age 1947 6 30 1929 11 4 death place New York , New York education Deerfield Academy occupation student residence spouse children parents John Gunther and Frances Gunther religion John Gunther jr November 4, 1929 June 30, 1947 , was the son of the American author John Gunther and is the central figure in John Gunther s book, Death Be Not Proud book Death Be Not Proud , which tells of the younger Gunther s death at the age of seventeen from a brain tumor . ref John Gunther, Death Be Not Proud 1949 . Harper Perennial edition 1998 ISBN 0 06 092989 8 ref Born in 1929 in Paris, France , Gunther was diagnosed with a brain tumour, later further diagnosed as glioblastoma multiforme , at age 16 and died from the illness 15 months later at Memorial Sloan Kettering Cancer Center Memorial Hospital , now known as Memorial Sloan Kettering Cancer Center, in New York City . ref cite news url http select.nytimes.com gst abstract.html?res F50F14FA3A5A147B93C0A9178CD85F438485F9 title JOHN GUNTHER JR. format pdf work The New York Times pages 23 date July 2, 1947 ref ref http muse.jhu.edu cgi bin access.cgi?uri journals bulletin of the history of medicine v078 78.4krueger.html Abstract of Krueger, Gretchen Marie Death Be Not Proud Children, Families, and Cancer in Postwar America Bulletin of the History of Medicine Volume 78, Number 4, Winter 2004, pp. 836 863 ref In his father s memoir, Johnny Gunther s struggle against the disease is documented and he is described as a very talented young man by all who knew him the sharpness of his intellect is evidenced by the fact that he corresponded briefly with Albert Einstein about physics before his illness prevented him from continuing his academic pursuits. Immediately before his death Gunther realized his dream of living long enough to graduate from University preparatory school prep school at Deerfield ... more details
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