CBG may refer to Cambridge Airport , England IATA code Cambridge railway station , England National Rail station code Cannabigerol , a non psychoactive cannabinoid found in Cannabis Blood glucose monitoring Capillary Blood Glucose Carrier battle group CBG AM , a CBC Radio One station in Gander, Canada CB Richard Ellis , which uses the NYSE ticker symbol CBG Centraal Bureau voor Genealogie , the Dutch research centre for genealogy Central Bank of The Gambia Cigar box guitar Communist Bulletin Group Transcortin Corticosteroid binding globulin Comic Book Guy , character on The Simpsons Comics Buyer s Guide Czech Board Games association of Czech board games designers and a game publisher. disambig DEFAULTSORT Cbg Category Broadcast call sign disambiguation pages de CBG fr CBG it CBG nl CBG ... more details
Image IgM scheme.svg thumb IgM , pictured, is an example of a macroglobulin. Another example is alpha 2 macroglobulin . A macroglobulin is a blood protein plasma globulin of high molecular weight . ref name urlDefinition macroglobulin from Online Medical Dictionary cite web url http cancerweb.ncl.ac.uk cgi bin omd?macroglobulin title Definition macroglobulin from Online Medical Dictionary format work accessdate ref Elevated levels of macroglobulins macroglobulinemia may cause manifestations of excess blood viscosity as is the case for IgM antibodies in Waldenstr m macroglobulinemia and or precipitate within blood vessels when temperature drops as in cryoglobulinaemia . Other macroglobulins include alpha 2 macroglobulin , which is elevated in nephrotic syndrome , diabetes , severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease . References reflist External links MeshName Macroglobulins protein stub Globulins Category Blood proteins ... more details
otheruses Phaseolin disambiguation Phaseolin is the main reserve globulin in seeds of the French bean Phaseolus vulgaris L. . ref http www.plantphysiol.org cgi reprint 109 3 777 The Bean Seed Storage Protein nowiki beta nowiki Phaseolin Is Synthesized, Processed, and Accumulated in the Vacuolar Type II Protein Bodies of Transgenic Rice Endosperm. Z. Zheng, K. Sumi, K. Tanaka and N. Murai, Plant Physiology, Vol 109, Issue 3 777 786 ref ref Physicochemical and structural studies of phaseolin from French bean seed. R. J. Blagrove, P. M. Colman, G. G. Lilley, A. Van Donkelaar and E. Suzuki, Plant Foods For Human Nutrition formely Qualitas Plantarum , Volume 33, Numbers 2 3, 227 229, doi 10.1007 BF01091313 ref It was named and first isolated and characterized by Thomas Burr Osborne chemist Thomas Burr Osborne in 1894 ref Osborne, T.B. 1894 J. Am. Chem. Soc., 16 10 , pp 703 712, doi 10.1021 ja02108a012 ref . References reflist Category Seed storage proteins Protein stub de Phaseolin ... more details
Pandy s test or Pandy s reaction is done on the Cerebrospinal fluid CSF cerebrospinal fluid to detect the elevated levels of protein s mainly globulins . This test is named after the Hungarian neurologist , P ndy K lm n 1868 1945 who developed this test in the year 1910. Principle Proteins globulin and albumin are precipitated by a saturated solution of phenol in water. The reagent used is phenol carbolic acid crystals dissolved in water or, pyrogallic acid or, cresol , usually termed as Pandy s reagent or Pandy s solution. Procedure One drop of CSF sample collected from the patient by lumbar puncture technique , is added to about 1ml of Pandy s solution. The turbid appearance signifies the presence of elevated levels of globulin protein in the CSF and is regarded as positive Pandy s reaction. The CSF from a normal adult shows no turbid precipitate indicates negative Pandy s reaction. Reactions and Results Proteins in the cerebrospinal fluid, normally albumin and globulin are present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. The normal CSF is clear and transparent fluid. The Pandy s reaction makes it translucent or opaque. Positive test A bluish white streak of precipitated proteins is seen. The degree of turbidity depends on the amount of protein in the CSF. It can vary from faint turbidity mild to moderate elevation in CSF proteins to dense milky precipitate high protein content in CSF . The positive Pandy s reaction may indicate one or more of the following pathological conditions Diabetes mellitus Brain tumor Meningioma , Acoustic neuroma or, Ependymoma Encapsulated brain abscess Spinal cord tumor Multiple sclerosis Acute purulent Meningitis Granulomatous Meningitis Carcinomatous Meningitis Syphilis protein may be normal if longstanding Guillain Barr syndrome Infectious polyneuritis Protein rises after 5 7 days Cushing s disease Connective tissue disease Uremia Myxedema Cerebral hemorrhage Negative tes ... more details
ATG may refer to Methionine ATG , the triplet code for the amino acid methionine Anti thymocyte globulin , antibodies to prevent and treat transplant rejection ATG Stores , an e tail site ISO 3166 1 alpha 3 Antigua and Barbuda , using its ISO 3166 1 alpha 3 country code Alexander the Great , king of Macedon, in northern Greece Tape gun Adhesive Transfer Gun , the formal name for a tape gun Advanced Technology Group , a division of Apple Computer Alaska Territorial Guard , a military reserve force in World War II Alternative Tourism Group , a Palestinian NGO Ambassador Theatre Group , a theatre group in the UK Anti tank warfare Anti tank gun , a mobile weapon used against armoured vehicles Anti Tank Guitar , a string instrument Art Technology Group , a software developer Art Theatre Guild , a Japanese film production company At the Gates , a melodic death metal band Aviation Technology Group , the defunct developer of the Javelin Very Light Jet VLJ disambig de ATG eo ATG es ATG fr ATG it ATG lt ATG nl ATG ja ATG ... more details
Infobox Disease Name Dysgammaglobulinemia Image Caption DiseasesDB ICD10 ICD10 D 80 2 d 80 ICD10 D 80 4 d 80 ICD9 ICD9 279.06 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D004406 Dysgammaglobulinemia is a type of immune disorder characterized by a reduction in some types of gamma globulin s. ref DorlandsDict three 000033050 Dysgammaglobulinemia ref ref EMedicineDictionary Dysgammaglobulinemia ref It is distinguished from hypogammaglobulinemia , which is a reduction in all types of gamma globulins. ref DorlandsDict four 000051615 hypogammaglobulinemia ref Hyper IgM syndrome can be considered a form of dysgammaglobulinemia, because it results from a failure of transformation from IgM production to production of other antibodies, and so the condition can be interpreted as a reduction of the other types. References reflist External links Raif S. Geha et al. http www.pubmedcentral.nih.gov articlerender.fcgi?artid 372130 Hyper Immunoglobulin M Immunodeficiency Dysgammaglobulinemia , Journal of Clinical Investigation , 1979 August 64 2 385 391, doi 10.1172 JCI109473. Accessed 2009 07 17. Andre Cruchaud et al. http jem.rupress.org cgi reprint 115 6 1141.pdf The site of synthesis of the 19S T globulins in dysgammaglobulinemia 1962 . Accessed 2009 07 17. Immune disorders Category Predominantly antibody de ciencies medicine stub ... more details
The Vroman effect , named after Leo Vroman , is exhibited by protein adsorption to a surface by blood plasma blood serum proteins. The highest mobility proteins generally arrive first and are later replaced by less motile proteins that have a higher affinity for the surface. A typical example of this occurs when fibrinogen displaces earlier adsorbed proteins on a biopolymer surface and is later replaced by high molecular weight kininogen. The process is delayed in narrow spaces and on hydrophobic surfaces fibrinogen is usually not displaced. Under stagnant conditions initial protein deposition takes place in the sequence albumin globulin fibrinogen fibronectin factor XII , and High molecular weight kininogen HMWK ref cite journal author Vroman, L., Adams, A. L., Fischer, G. C., Munoz, P. C. title Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces date 1980 journal Blood issue 55 pages 156 PMID 7350935 ref . References Reflist Molecular cell biology stub Engineering stub Category Surface chemistry Category Blood de Vroman Effekt nl Vroman effect ... more details
Infobox Disease Name Tuberculous pericarditis Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D010495 Tuberculous pericarditis is a form of pericarditis . Pericarditis caused by tuberculosis is difficult to diagnose, because definitive diagnosis requires culturing Mycobacterium tuberculosis from aspirated pericardium pericardial fluid or pericardial Wiktionary biopsy biopsy , which requires high technical skill and is often not diagnostic the yield from culture is low even with optimum specimens . The Tygerberg score Tygerberg scoring system helps the clinician to decide whether pericarditis is due to tuberculosis or whether it is due to another cause night sweats 1 point , weight loss 1 point , fever 2 point , serum globulin > 40g l 3 points , blood total leucocyte count < 10 x 10 sup 9 sup l 3 points a total score of 6 or more is highly suggestive of tuberculous pericarditis. ref cite journal author Reuter H, Burgess L, van Vuuren W, Doubell A. title Diagnosing tuberculous pericarditis journal Q J Med year 2006 volume 99 pages 827&ndash 39 pmid 17121764 issue 12 doi 10.1093 qjmed hcl123 ref Pericardial fluid with an interferon gamma interferon level greater than 50 Wiktionary picogram pg ml is highly specific for tuberculous pericarditis. References reflist Gram positive actinobacteria diseases Circulatory system pathology Category Pericardial disorders ... more details
by enzymatic cleavage of a leukophilic gamma globulin. It stimulates the phagocytic activity ... fragment of the gamma globulin molecule. See also Oligoester External links http www.nlm.nih.gov ... more details
lymphoproliferative disorder. Such antibodies include Anti thymocyte globulin ATG , Anti lymphocyte globulin ALG and OKT3 . Polyclonal PTLD may form tumor masses and present with symptoms due to a mass ... more details
globulin also known as Coombs reagent . If immunoglobulin or complement factors have been fixed on to the RBC surface in vitro , the antihuman globulin will Agglutination biology agglutinate the RBCs ... saline and then incubated with antihuman globulin. If antibodies have bound to RBC surface antigens ... antihuman globulin also known Coombs reagent in this stage, and the indirect Coombs test will be positive ... also known as Coombs antiglobulin or antihuman globulin is used in both the direct Coombs test and the indirect Coombs test. Coombs reagent is antihuman globulin . It is made by injecting human globulin ... more details
The liver plays the major role in producing proteins that are secretion secreted into the blood, including major plasma proteins, factors in hemostasis and fibrinolysis , carrier proteins, hormones, prohormones and apolipoproteins Major plasma proteins Human serum albumin , osmolyte and carrier protein fetoprotein , the fetal counterpart of serum albumin Soluble plasma fibronectin , forming a blood clot that stops bleeding C reactive protein , opsonin on microbes ref name Immunology182 Lippincott s Illustrated Reviews Immunology. Paperback 384 pages. Publisher Lippincott Williams & Wilkins July 1, 2007 . Language English. ISBN 978 0781795432. Page 182 ref , acute phase protein Various other globulins Factors in hemostasis and fibrinolysis Stimulators of coagulation All factors in the Coagulation The coagulation cascade coagulation cascade , except factor VIII from endothelium Inhibitors of coagulation , inactivate an enormous variety of proteinases 2 macroglobulin 1 antitrypsin Antithrombin III Protein S Protein C Fibrinolysis , breakdown of fibrin clots plasminogen Inhibitors of fibrinolysis 2 antiplasmin Complement components C1 9, Complement component 3 C3 Carrier proteins Albumin , carries thyroid hormone s and other hormones, particularly fat soluble ones, fatty acids to the liver, unconjugated bilirubin , many medication drugs and calcium Ca sup 2 sup Ceruloplasmin , carries copper Transcortin , carries cortisol , aldosterone and progesterone Haptoglobin , carries free hemoglobin released from erythrocytes Hemopexin , carries free heme released from hemoglobin Insulin like growth factor binding protein IGF binding protein , carries insulin like growth factor 1 Major urinary proteins , carries pheromones in rodents Retinol binding protein , carries retinol Sex hormone binding globulin , carries sex hormones , specifically testosterone and estradiol Thyroxine binding globulin , carries the thyroid hormones thyroxine T4 and 3,5,3 triiodothyronine T3 Transthy ... more details
orphan date January 2010 Placental alpha microglobulin 1 PAMG 1 was isolated in 1975 from amniotic fluid by D. Petruin and was originally referred to as specific alpha 1 globulin of placenta. ref name D. Petrunin, et al., Immunological Identification of Organ Specific alpha 1 Globulin of Human Placenta and Its Content in the Amniotic Fluid, in Akusherstvo i Ginekologiya, 1977, N 1, pp. 64 65, Moscow, USSR D. Petrunin, et al., Immunological Identification of Organ Specific alpha 1 Globulin of Human Placenta and Its Content in the Amniotic Fluid, in Akusherstvo i Ginekologiya, 1977, N 1, pp. 64 65, Moscow, USSR ref PAMG 1 is present in blood and the amniotic fluid and cervico vaginal discharge of pregnant women. The concentration of PAMG 1 in the amniotic fluid of pregnant women 2,000 25,000 ng ml , however, is several thousand magnitudes higher than that found in their background cervico vaginal discharge when the fetal membranes are intact 0.05 0.2 ng ml . It has been found to be present in amniotic fluid in significantly high concentrations throughout all three trimesters of pregnancy. Diagnostic potential Because of its contrasting concentrations in the amniotic fluid and background cervico vaginal discharge of pregnant women, PAMG 1 proves to be an excellent protein marker for amniotic fluid. Detecting amniotic fluid via PAMG 1 becomes particularly important when determining whether or not fetal membranes are ruptured. Premature rupture of fetal membranes or Premature rupture of membranes PROM as it is more commonly referred occurs in roughly 10 of pregnancies ref name Alexander JM, Cox SM. Clinical course of premature rupture of the membranes. Semin Perinatol 1996 20 369 374 Alexander JM, Cox SM. Clinical course of premature rupture of the membranes. Semin Perinatol 1996 20 369 374 ref and is one of the most common diagnoses associated with premature delivery and neonatal complications that requires admission to the NICU. ref name Cousins L, Smok D, Lo ... more details
Unreferenced date December 2009 Infobox disease Name Cytokine release syndrome Image Caption DiseasesDB 34296 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Cytokine release syndrome is a common immediate complication occurring with the use of anti T cell antibody infusions such as Anti thymocyte globulin ATG , OKT3 and TGN1412 , but also with the CD 20 antibody rituximab . Severe cases are known as cytokine storm s. The pathogenesis is that the antibody antibodies bind to the T cell receptor, activating the T cells before they are destroyed. The cytokine s released by the activated T cells produce a type of systemic inflammatory response syndrome systemic inflammatory response similar to that found in severe infection characterised by hypotension , pyrexia and rigor medicine rigors . The patient feels very unwell, as if in a high fever &ndash indeed, the cytokine release syndrome is effectively a type of non infective fever. Deaths due to cytokine release syndrome with OKT3 muromonab CD3 have been reported, and it can cause life threatening pulmonary edema if the patient is fluid overloaded. However, if treated appropriately it is usually not dangerous, just extremely unpleasant for the patient. The effect is greatly reduced by using low dose OKT3 e.g. 2 mg instead of 5 mg, slow infusion instead of rapid injection, intravenous administration of an anti histamine such as chlorphenamine and a corticosteroid such as hydrocortisone prior to starting the ATG OKT3 infusion, with further doses of anti histamine and steroid given during the infusion if necessary, Acetaminophine 500 mg by mouth 1 hour before infusion to prevent fever. Moreover, it is recommended that any overhydration to be corrected before the administration the 1st dose either by dialysis or with intravenous furosemide, to prevent the possible development of pulmonary oedema. See also cytokine storm , life threatening massive release of cytokines DEFAULTSORT Cytokine R ... more details
Infobox disease Name Hyperviscosity syndrome ICD10 ICD9 ICDO Image Caption OMIM MedlinePlus eMedicineSubj emerg eMedicineTopic 756 DiseasesDB 20944 Hyperviscosity syndrome is a group of symptoms triggered by increase in the viscosity of the blood . Symptoms of high blood viscosity include spontaneous bleeding from mucous membrane s, visual disturbances due to retinopathy , and neurologic symptoms ranging from headache and Vertigo medical vertigo to seizures and coma . Hyperviscosity syndrome may be caused by an increase in blood plasma serum proteins or cells. Increased levels of proteins are seen with monoclonal gammopathy monoclonal gammopathies such as Waldenstr m macroglobulinemia and in multiple myeloma particularly IgA and IgG3 . High cell counts are seen in conditions such as polycythemia raised red blood cell s or leukemia more white blood cell s, especially in acute leukemic blast crisis acute leukemic blast crises . Diagnosis Serum viscosity can be measured. Normal is between 1.4 and 1.8 centipoise s but to have symptoms from hyperviscosity, serum viscosity is usually greater than 5 centipoises. Patients will also have evidence of their underlying disorder. Those with myeloma will typically display a rouleaux formation on a peripheral smear and a large globulin gap, indicative of a significant paraprotein load. While viscosity can be directly measured, results can take a few days to return and thus a high index of suspicion is required to make the diagnosis in a timely manner. If hyperviscosity is suspected, treatment may need to be started prior to obtaining the official viscosity level. Treatment Plasmapheresis may be used to decrease viscosity in the case of myeloma, whereas leukapheresis or phlebotomy may be employed in a leukemic or polycythemic crisis, respectively. Blood transfusion s should be used with caution as they can increase serum viscosity. Hydration is a temporizing measure to employ while preparing pheresis. Even after treatment, the cond ... more details
protein Name complement factor properdin caption image width HGNCid 8864 Symbol CFP AltSymbols PFC EntrezGene 5199 OMIM 300383 RefSeq NM 002621 UniProt P27918 PDB ECnumber Chromosome X Arm p Band 11.4 LocusSupplementaryData Properdin or factor P is a globulin protein found in the blood blood plasma serum of more complex animal s. In the Complement biology complement system, an innate immunity series of proenzyme s dissolved in the circulation, it is also called Factor P . Function It is known that it participates in some specific immune response s. It plays a part in Biological tissue tissue inflammation as well as the engulfing of pathogen s by phagocyte s. In addition it is known to help to neutralize some virus es. As a component of the Complement biology Alternative pathway alternative pathway for complement activation otherwise known as the properdin pathway , it complexes with another protein, C3b , to stabilize the alternative C3 convertase C3bBb that then cleaves more C3. Image Droga alternatywna.png thumb center 500px Alternative pathway. Properdin is the P in the blue circles. Some labels are in Polish. The alternative pathway is not dependent on antibodies . This branch of the complement system is activated by IgA immune complexes and bacterial endotoxins , polysaccharide s, and cell wall s, and results in producing anaphylatoxins , opsonins , chemotactic factors , and the membrane attack complex , all of which help fight pathogens. History Properdin was discovered in 1954 by Dr. Louis Pillemer of the Institute of Pathology now the Department of Pathology at Case Western Reserve University . Deficiency Properdin deficiency is a rare X linked disease in which properdin is deficient. Affected individuals are susceptible to fulminant meningococcal disease. ref http www.bioporto.com articles properdin Dr. Lars Otto Uttenthal Properdin September 01 2005 ref External links MeshName Properdin Reflist biochem stub Beta globulins Complement system Category Complem ... more details
Drugbox Verifiedfields changed verifiedrevid 458275362 image Monoclonal antibody data type mab mab type mab source o target CD147 Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite changed ?? CAS number 244096 20 6 ATC prefix none ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data chemical formula molecular weight Gavilimomab also known as ABX CBL is a mouse monoclonal antibody intended for use as an immunosuppressive biologic medical product biologic treatment of glucocorticoid resistant graft versus host disease . It binds to the antigen CD147 . ref name findarticles Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy. ref name Macmillan 2007 Cite journal author1 Macmillan, ML author2 Couriel, D author3 Weisdorf, DJ author4 Schwab, G author5 Havrilla, N author6 Fleming, TR author7 Huang, S author8 Roskos, L author9 Slavin, S title A phase 2 3 multicenter randomized clinical trial of ABX CBL versus ATG as secondary therapy for steroid resistant acute graft versus host disease. journal Blood volume 109 issue 6 pages 2657 62 month Mar year 2007 doi 10.1182 blood 2006 08 013995 pmid 17110457 ref It was originally developed by Abgenix , ref name findarticles http findarticles.com p articles mi m0EIN is 2001 Jan 10 ai 68950045 findarticles.com Sangstat to Provide Clinical Development Update At JP Morgan H&Q Conference in San Francisco ref which was later acquired by Amgen . References reflist immunosuppressants Monoclonals for immune system Category Monoclonal antibodies for tumors monoclonal antibody stub antineoplastic drug stub it Gavilimomab ... more details
Refimprove date June 2008 Infobox Disease Name Antithrombin III deficiency Image Caption DiseasesDB 783 ICD10 ICD10 D 68 80 d 65 ICD9 ICD9 289.81 ICDO OMIM 613118 MedlinePlus eMedicineSubj ped eMedicineTopic 119 MeshID D020152 Antithrombin III deficiency is a rare disease rare hereditary disorder that generally comes to light when a patient suffers recurrent venous thrombosis and pulmonary embolism . Inheritance is usually autosomal Dominance genetics dominant , though a few recessive cases have been noted. ref OMIM 107300 ref The disorder was first described by Egeberg in 1965. ref Egeberg O. 1965 Inherited antithrombin deficiency causing thrombophilia . Thromb Diath Haemorrh. 13 516 520. PMID 14347873. ref The patients are treated with anticoagulant s or, more rarely, with antithrombin concentrate. In renal failure , especially nephrotic syndrome , antithrombin is lost in the urine, leading to a higher activity of Factor II and Factor X and in increased tendency to thrombosis . Heparin resistance Patients with AT3 deficiency need higher doses of heparin. AT3 is known to slowly break up fibrin and factor X. When heparin binds to AT3, AT3 will break up fibrin and factor X faster. AT3 is not dependent on vitamin K so unlike warfarin, giving vitamin K will not reverse the effects of heparin. Heparin is used in bridge therapy when initiating a patient on warfarin when in a hospital setting. It can be used in DVT prophylaxis and treatment, acute coronary syndromes, and ST segment elevated MI. See also Antithrombin ATryn References reflist External links http www.med.uiuc.edu hematology PtAntithrombin.htm Information on antithrombin from UIUC http www.nattinfo.org Non profit advocacy group for patients and families with antithrombin deficiency Hematology Disorders of globin and globulin proteins Category Serpinopathies Category Rare diseases Category Coagulopathies disease stub pt Defici ncia de antitrombina III ... more details
Drugbox Verifiedfields changed verifiedrevid 457121609 Monoclonal antibody data type mab mab type mab source u target hepatitis B surface antigen Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number Ref cascite changed ?? CAS number 569658 80 6 ATC prefix none ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA Chemical data C 6416 H 9924 N 1732 O 1982 S 44 molecular weight Exbivirumab is a human monoclonal antibody ref http whqlibdoc.who.int druginfo INN 2005 list53.pdf WHO Drug Information ref developed for the treatment of hepatitis B infections. ref cite journal last Shouval first D coauthors et al. year 2006 title Anti Viral Effects, Pharmacokinetics and Safety of Two Human Monoclonal Anti Hbs Libivirumab Exbivirumab Versus Hepatitis B Immune Globulin Hbig in Hepatits B Virus Hbv in Liver Transplant Lt Recipients journal Hepatology volume 44 issue 4 doi 10.1002 hep.21395 page 196A pmid 17001593 pages 188A 700A ref References reflist Monoclonals for infectious disease and toxins Category Monoclonal antibodies antiinfective drug stub monoclonal antibody stub it Exbivirumab ... more details
Drugbox Verifiedfields changed verifiedrevid 458269945 Monoclonal antibody data type mab mab type mab source u target Hepatitis B surface antigen Clinical data tradename pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite changed ?? CAS number 569658 79 3 ATC prefix none ATC suffix PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data C 6598 H 10232 N 1788 O 2060 S 46 molecular weight 149.04 kDa Libivirumab is a human monoclonal antibody directed against the hepatitis B virus. ref http whqlibdoc.who.int druginfo 18 2 2004 INN91.pdf WHO Drug Information ref ref cite journal last Shouval first D coauthors et al. year 2006 title Anti Viral Effects, Pharmacokinetics and Safety of Two Human Monoclonal Anti Hbs Libivirumab Exbivirumab Versus Hepatitis B Immune Globulin Hbig in Hepatits B Virus Hbv in Liver Transplant Lt Recipients journal Hepatology volume 44 issue 4 doi 10.1002 hep.21395 page 196A pmid 17001593 pages 188A 700A ref References reflist Monoclonals for infectious disease and toxins Category Monoclonal antibodies antiinfective drug stub monoclonal antibody stub it Libivirumab ... more details
main Pregnancy test hCG human chorionic gonadotropin human chorionic gonadotrophin is a hormone secreted in pregnancy that is made by the developing embryo soon after conception and later by the syncytiotrophoblast part of the placenta to maintain the fetus fetal viability preventing the disintegration of the corpus luteum of the ovary and thereby maintaining progesterone production that is critical for a pregnancy in humans it also affects the immune tolerance of the pregnancy. hCG is excreted in the urine of pregnant women. Detection of this hormone in urine or Blood serum serum is an easy first method of diagnosis of pregnancy. The hormone can be detected as early as the sixth day after Conception biology conception . hCG is also an important tumor marker because it is produced by some kinds of tumor , such as seminoma , choriocarcinoma , germ cell tumors , hydatidiform mole formation, teratoma with elements of choriocarcinoma , and Pregnancy test Pregnancy detection kits containing a strip or card impregnated with anti hCG globulin are readily available. The test is executed by immersing the proper end of the strip in urine or sprinkling three drops of urine on the indicated site of a card. Result is readable within two to three minutes. References Shaws Textbook of Gynaecology Dutta, DC Textbook of Obstetrics and Gynaecology External links commons Pregnancy test Urine based HCG test Urine based HCG test http www.whfreeman.com kuby content anm kb07an01.htm A descriptive animation of the principle behind a lateral flow ELISA Sandwich ELISA sandwich ELISA home pregnancy test. http www.sutherlandhealth.com companies condomania product range vision hcg pregnancy midstream human repro stub Pregnancy Category Pregnancy tests ... more details
enzyme Name decylhomocitrate synthase EC number 2.3.3.4 CAS number 51845 40 0 IUBMB EC number 2 3 3 4 GO code 0050458 image width caption In enzymology , a decylhomocitrate synthase EC number 2.3.3.4 is an enzyme that catalysis catalyzes the chemical reaction dodecanoyl CoA H sub 2 sub O 2 oxoglutarate math rightleftharpoons math 3S,4S 3 hydroxytetradecane 1,3,4 tricarboxylate CoA The 3 substrate biochemistry substrates of this enzyme are dodecanoyl CoA , water H sub 2 sub O , and 2 oxoglutarate , whereas its two product chemistry products are 3S,4S 3 hydroxytetradecane 1,3,4 tricarboxylate and coenzyme A CoA . This enzyme belongs to the family of transferase s, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is dodecanoyl CoA 2 oxoglutarate C dodecanoyltransferase thioester hydrolysing, 1 carboxyundecyl forming . Other names in common use include 2 decylhomocitrate synthase , 3 hydroxytetradecane 1,3,4 tricarboxylate 2 oxoglutarate lyase , and CoA acylating . References reflist 1 cite journal author Mahlen A date 1973 title Purification and some properties of 2 decylhomocitrate synthase from Penicillium spiculisporum journal Eur. J. Biochem. volume 38 pages 32&ndash 9 pmid 4774124 doi 10.1111 j.1432 1033.1973.tb03029.x issue 1 cite journal author L, Narendra AM, Mehra NK, Saxena R, Choudhry VP date 2006 title Fludarabine, cyclophosphamide and horse antithymocyte globulin conditioning regimen for allogeneic peripheral blood stem cell transplantation performed in non HEPA filter rooms for multiply transfused patients with severe aplastic anemia journal Bone. Marrow. Transplant. volume 37 pages 745&ndash 9 pmid 16518427 doi 10.1038 sj.bmt.1705321 issue 8 transferase stub Category EC 2.3.3 Category Enzymes of unknown structure it Decilomocitrato sintasi ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 D 56 4 d 55 ICD9 ICD9 282.7 ICDO OMIM 141749 MedlinePlus eMedicineSubj eMedicineTopic MeshID Hereditary persistence of fetal hemoglobin HPFH, BrE Hereditary persistence of foetal haemoglobin is a benign condition in which significant fetal hemoglobin hemoglobin F production continues well into adulthood, disregarding the normal shutoff point after which only adult type hemoglobin should be produced. ref http cancerweb.ncl.ac.uk cgi bin omd?hereditary persistence of foetal haemoglobin ref Causes This is usually caused by mutation s in the globin gene cluster. Fact date September 2008 The percentage of incorrect expression might be as low as 10 15 or as high as 100 of the total hemoglobin, usually higher in homozygotes than in heterozygotes. ref http www.enerca.org PublicPages Anaemiascovered HereditarypersistanceoffoetalhaemoglobinHPFH tabid 177 Default.aspx ref Epidemiology HPFH may alleviate the severity of certain hemoglobinopathy hemaglobinopathies and thalassemia s, and is selected for in populations with a high prevalence of these conditions which in turn are often selected for in areas where malaria is endemic . Thus, it has been found to affect Americans of African and Greek descent. ref cite journal author Friedman S, Schwartz E title Hereditary persistence of foetal haemoglobin with beta chain synthesis in cis position Ggamma beta HPFH in a negro family journal Nature volume 259 issue 5539 pages 138 40 year 1976 month January pmid 1246351 doi 10.1038 259138a0 url http www.nature.com nature journal v259 n5539 abs 259138a0.html ref Presentation The condition is usually asymptomatic, and is only noticed when screening for other hemoglobin disorders. References reflist medicine stub Myeloid hematologic disease Category Hereditary hemolytic anemias Category Disorders of globin and globulin proteins ru ... more details
chembox ImageFile Androstanediol.png ImageSize 200px IUPACName small 3 S ,5 S ,8 R ,9 S ,10 S ,13 S ,14 S ,17 S 10,13 Dimethyl 2,3,4,5,6,7,8,9,11,12,14,15,16,17 tetradecahydro 1H cyclopenta a phenanthrene 3,17 diol small OtherNames 3beta,17beta androstanediol Section1 Chembox Identifiers CASNo 571 20 0 PubChem 242332 SMILES C C 12CC C H C C H 1CC C H 3 C H 2CC C 4 C H 3CC C H 4O C O ChemSpiderID 211834 InChI 1 C19H32O2 c1 18 9 7 13 20 11 12 18 3 4 14 15 5 6 17 21 19 15,2 10 8 16 14 18 h12 17,20 21H,3 11H2,1 2H3 t12 ,13 ,14 ,15 ,16 ,17 ,18 ,19 m0 s1 InChIKey CBMYJHIOYJEBSB YSZCXEEOBK StdInChI 1S C19H32O2 c1 18 9 7 13 20 11 12 18 3 4 14 15 5 6 17 21 19 15,2 10 8 16 14 18 h12 17,20 21H,3 11H2,1 2H3 t12 ,13 ,14 ,15 ,16 ,17 ,18 ,19 m0 s1 StdInChIKey CBMYJHIOYJEBSB YSZCXEEOSA N Section2 Chembox Properties Formula C sub 19 sub H sub 32 sub O sub 2 sub MolarMass 292.46 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 3 Androstanediol is an androstanediol ref name pmid11735427 cite journal author Chambon C, Bennat D, Delolme F, et al title Photoaffinity labeling of human sex hormone binding globulin using 17alpha alkylamine derivatives of 3beta androstanediol substituted with azidonitrophenylamido, azidonitrophenylamino, or trifluoroazidonitrophenylamino chromophores. Localization of Trp 84 in the vicinity of the steroid binding site journal Biochemistry volume 40 issue 50 pages 15424 35 year 2001 month December pmid 11735427 doi 10.1021 bi011504s ref derived from Dihydrotestosterone DHT in a reaction catalyzed by the enzyme 3 beta HSD 3 HSD See also Steroid References reflist DEFAULTSORT Androstanediol, 3 Category Steroids steroid stub fa sr 3 Androstandiol ... more details
Encyclopedia
top
