In medicine , glycoprotein IIb IIIa inhibitors , also GpIIb IIIa inhibitors , is a class of antiplatelet agent s. Several GpIIb IIIa inhibitors exist abciximab ReoPro eptifibatide Integrilin tirofiban Aggrastat Use Glycoprotein IIb IIIa inhibitors are frequently used during percutaneous coronary intervention angioplasty with or without intracoronary stent placement . They work by preventing platelet aggregation and thrombus formation. They do so by inhibition of the GpIIb IIIa receptor on the surface of the platelet s. They may also be used to treat acute coronary syndromes, without percutaneous coronary intervention, depending on TIMI risk. They should be given intravenously. The oral form is associated with increased mortality and hence should not be given. In integrin nomenclature glycoprotein IIb IIIa is called IIb 3. History Their development arose from the understanding of Glanzmann s thrombasthenia , a condition in which the GpIIb IIIa is lacking. ref Seligsohn U. Glanzmann thrombasthenia a model disease which paved the way to powerful therapeutic agents. Pathophysiol Haemost Thromb. 2002 Sep Dec 32 5 6 216 7. DOI 10.1159 000073569 PMID 13679645. http content.karger.com ProdukteDB produkte.asp?Aktion ShowPDF&ArtikelNr 73569&ProduktNr 224034&Ausgabe 229381&filename 73569.pdf Free Full Text . ref References references Antithrombotics Category gpIIb IIIa inhibitors de Glykoprotein 2b 3a Hemmer pl Inhibitory receptora glikoproteinowego IIb IIIa pt Inibidores da glicoprote na IIb IIIa ... more details
protein Name ITGA2B integrin, alpha 2b platelet glycoprotein IIb of IIb IIIa complex, antigen CD41 caption image width HGNCid 6138 Symbol ITGA2B AltSymbols GP2B EntrezGene 3674 OMIM 607759 RefSeq NM 000419 UniProt P08514 PDB ECnumber Chromosome 17 Arm q Band 21.32 LocusSupplementaryData protein Name ITGB3 integrin, beta 3 platelet glycoprotein IIIa, antigen CD61 caption image width HGNCid 6156 Symbol ITGB3 AltSymbols GP3A EntrezGene 3690 OMIM 173470 RefSeq NM 000212 UniProt P05106 PDB ECnumber Chromosome 17 Arm q Band 21.32 LocusSupplementaryData In medicine , glycoprotein IIb IIIa gpIIb IIIa , also known as integrin sub IIb sub sub 3 sub is an integrin complex found on platelet s. It is a receptor for fibrinogen and aids in coagulation Platelet activation platelet activation . The complex is formed via calcium dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. ref name pmid7535429 cite journal author Calvete JJ title On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor journal Proc. Soc. Exp. Biol. Med. volume 208 issue 4 pages 346 60 year 1995 pmid 7535429 doi issn ref ref name pmid10605720 cite journal author Shattil SJ title Signaling through platelet integrin alpha IIb beta 3 inside out, outside in, and sideways journal Thromb. Haemost. volume 82 issue 2 pages 318 25 year 1999 pmid 10605720 doi issn ref Platelet activation by Adenosine diphosphate ADP blocked by clopidogrel leads to a conformational change in platelet gpIIb IIIa receptors that induces binding to fibrinogen ... , tirofiban . Pathology Defects in glycoprotein IIb IIIa cause Glanzmann s thrombasthenia . ref name ... in immune thrombocytopenic purpura . ref name pmid18096470 cite journal author McMillan R title ... url http linkinghub.elsevier.com retrieve pii S0037 1963 07 00159 X ref Medicine Glycoprotein IIb ... or stroke . See also Glycoprotein IIb IIIa inhibitors References Reflist External links MeshName ... more details
enzyme Name glycoprotein 3 alpha L fucosyltransferase EC number 2.4.1.214 CAS number 68247 53 0 IUBMB EC number 2 4 1 214 GO code 0018392 image width caption In enzymology , a glycoprotein 3 alpha L fucosyltransferase EC number 2.4.1.214 is an enzyme that catalysis catalyzes the chemical reaction GDP L fucose N sub 4 sub N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 N acetyl beta D glucosaminyl asparagine math rightleftharpoons math GDP N sub 4 sub N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 alpha L fucosyl 1 3 N acetyl beta D glucosaminyl asparagine The 5 substrate biochemistry substrates of this enzyme are GDP L fucose , N4 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N , acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D , mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 N acetyl beta D , and glucosaminyl asparagine , whereas its 5 product chemistry products are guanosine diphosphate GDP , N4 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N , acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D , mannosyl 1 4 N acetyl beta ... name of this enzyme class is GDP L fucose glycoprotein L fucose to asparagine linked N acetylglucosamine ... , GDP L fucose glycoprotein L fucose to asparagine linked , N acetylglucosamine of , 4 N ... of cDNAs encoding alpha1,3 fucosyltransferase homologues from Arabidopsis thaliana journal Biochim ... glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster Potential ..., Staudacher E, Grimm R, Glossl J, Altmann F date 1999 title Purification, cDNA cloning, and expression of GDP L Fuc Asn linked GlcNAc alpha1,3 fucosyltransferase from mung beans journal J. Biol. Chem ... alpha1 3 fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis ... more details
PBB geneid 4340 Myelin Oligodendrocyte Glycoprotein MOG is a glycoprotein believed to be important in the process of myelin ization of nerve s in the central nervous system CNS . In humans this protein ..., Kerlero de Rosbo N, Dautigny A title Structure of the human myelin oligodendrocyte glycoprotein gene ... N, Pontarotti P, Coppin H title The human myelin oligodendrocyte glycoprotein MOG gene complete nucleotide ... glycoprotein journal J. Neurochem. volume 63 issue 6 pages 2353 6 year 1994 month December ..., Artzt K, Lindahl KF, Dautigny A title Myelin oligodendrocyte glycoprotein is a member of a subset ... name Roth and have a range varying from 242 to 6484 bp. Structure Because of alternatively spliced from human mRNA of MOG gene forming at least nine isoforms. ref name pmid17573820 cite journal author Boyle LH, Traherne JA, Plotnek G, Ward R, Trowsdale J title Splice variation in the cytoplasmic domains of myelin oligodendrocyte glycoprotein affects its cellular localisation and transport journal ... doi 10.1111 j.1471 4159.2007.04687.x ref The crystal structure of myelin oligodendrocyte glycoprotein was determined by x ray diffraction at a resolution of 1.45 Angstrom, using protein from the Norway ... into the antigenicity of myelin oligodendrocyte glycoprotein journal Proc. Natl. Acad. Sci. U.S.A. ... al. title The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple ... Y, Tien P title Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella ... ref name Berger1 cite journal author Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer ... theory, these antibodies that result from the immune response might be factors that contribute to the development ... positive for antibodies were able to benefit from early treatment . ref name Greeve Over a 12 month ..., Munger KL, Reindl M, O Reilly EJ, Levin LI, Berger T, Ascherio A title Myelin oligodendrocyte glycoprotein ... caused by MS, apart from biologically active antibodies , ref name BergerInt it may be that antibodies ... more details
Pfam box Symbol GP120 Name Envelope glycoprotein GP120 image HIV gp120 core.png width caption Pfam PF00516 InterPro IPR000777 SMART Prosite SCOP 1gc1 TCDB OPM family OPM protein PDB PDB3 2b4c G 160 483 ... 2bf1 A 187 505 Envelope glycoprotein GP120 or gp120 is a glycoprotein exposed on the surface of the Structure and genome of HIV HIV envelope . The 120 in its name comes from its molecular weight of 120 ... Three gp120s, bound as heterodimer s to a transmembrane glycoprotein, gp41 , are thought to combine ... near its receptor binding site. The glycoprotein gp120 is anchored to the viral membrane , or envelope, via non covalent bonds with the transmembrane glycoprotein, gp41. It is involved in entry into cells ... author Wyatt, R., Kwong, P., Desjardins, E., Sweet, R., Robinson, J., Hendrickson, W., and Sodroski ..., C., Kebaabetswe, L., Rossenkhan, R., Nkwe, D., Margolin, L., Musonda, R., Moyo, S., Woldegabriel ... extending from gp120 might obscure possible antibody binding sites. ref name Wood cite journal author ... R, Corey L, Zhu T, Mullins JI title Env length and N linked glycosylation following transmission of human ... author Pantophlet R, Burton DR title GP120 target for neutralizing HIV 1 antibodies journal Annu ..., which make it difficult for antibodies to bind to it. gp120 can also easily be shed from the surface ... glycoprotein that is involved in the metastable attachment of gp120 to CD4 has now been ... al. year 2007 title Characterization of gp120 Hydrolysis by IgA Antibodies from Humans without HIV ... purified from the blood plasma and saliva of HIV seronegative subjects cleaved gp120 more effectively ..., anything which binds to gp120 s target can block gp120 from binding to a cell by being physically ... cells, ref name pmid15910762 cite journal author Price TO, Ercal N, Nakaoke R, Banks WA title HIV 1 ... gp120.htm Human Immunodeficiency Virus Glycoprotein 120 refbegin cite journal author Vashistha H ... RVDocSum&ordinalpos 1 See also HIV structure and genome Viral proteins DEFAULTSORT Envelope Glycoprotein ... more details
enzyme Name glycoprotein 6 alpha L fucosyltransferase EC number 2.4.1.68 CAS number 9033 08 3 IUBMB EC number 2 4 1 68 GO code 0008424 image width caption In enzymology , a glycoprotein 6 alpha L fucosyltransferase EC number 2.4.1.68 is an enzyme that catalysis catalyzes the chemical reaction GDP L fucose N sub 4 sub N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 N acetyl beta D glucosaminyl asparagine math rightleftharpoons math GDP N sub 4 sub N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 alpha L fucosyl 1 6 N acetyl beta D glucosaminyl asparagine The 5 substrate biochemistry substrates of this enzyme are GDP L fucose , N4 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N , acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D , mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 N acetyl beta D , and glucosaminyl asparagine , whereas its 5 product chemistry products are guanosine diphosphate GDP , N4 N acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 3 N , acetyl beta D glucosaminyl 1 2 alpha D mannosyl 1 6 beta D , mannosyl 1 4 N acetyl beta D glucosaminyl 1 4 alpha L , and fucosyl 1 6 N acetyl beta D glucosaminyl asparagine . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP L fucose glycoprotein L fucose to asparagine linked N acetylglucosamine ... asparagine 6 alpha L fucosyltransferase . Other names in common use include GDP fucose glycoprotein ... glycoprotein fucosyltransferase , glycoprotein fucosyltransferase , guanosine diphosphofucose glycoprotein fucosyltransferase , GDP L fucose glycoprotein L fucose to asparagine linked , N acetylglucosamine ... from porcine liver journal Carbohydr. Res. volume 100 pages 365&ndash 92 pmid 7083256 doi 10.1016 ... more details
selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O linked poly ... glycoprotein ligand 1 and effect of its blockade protection from ischemia reperfusion injury in liver ... 6404 accessdate ref P selectin glycoprotein ligand 1 is a glycoprotein found on white blood cells and endothelium ... journal author Sako D, Chang XJ, Barone KM, et al. title Expression cloning of a functional glycoprotein ... localization of the gene encoding human P selectin glycoprotein ligand. journal J. Biol. Chem ... author Wilkins PP, Moore KL, McEver RP, Cummings RD title Tyrosine sulfation of P selectin glycoprotein .... title Post translational modifications of recombinant P selectin glycoprotein ligand 1 required for binding ... P selectin glycoprotein ligand 1 PSGL 1 is a ligand for L selectin in neutrophil aggregation. journal ... DM, Ding H, et al. title Isolated P selectin glycoprotein ligand 1 dynamic adhesion to P and E selectin ... K, et al. title A novel P selectin glycoprotein ligand 1 monoclonal antibody recognizes an epitope ... RD title Noncovalent association of P selectin glycoprotein ligand 1 and minimal determinants for binding ... of P selectin glycoprotein ligand 1 with a natural killer cell restricted sulfated lactosamine ... PS, Denis CV, Weiss L, et al. title P Selectin glycoprotein ligand 1 PSGL 1 is expressed on platelets ... External links MeshName P selectin glycoprotein ligand 1 NLM content Clusters of differentiation ... more details
enzyme Name glycoprotein N palmitoyltransferase EC number 2.3.1.96 CAS number 97162 74 8 IUBMB EC number 2 3 1 96 GO code 0018010 image width caption In enzymology , a glycoprotein N palmitoyltransferase EC number 2.3.1.96 is an enzyme that catalysis catalyzes the chemical reaction palmitoyl CoA glycoprotein math rightleftharpoons math CoA N palmitoylglycoprotein Thus, the two substrate biochemistry substrates of this enzyme are palmitoyl CoA and glycoprotein , whereas its two product chemistry products are coenzyme A CoA and N palmitoylglycoprotein . This enzyme belongs to the family of transferase s, specifically those acyltransferase s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is palmitoyl CoA glycoprotein N palmitoyltransferase . This enzyme is also called mucus glycoprotein fatty acyltransferase . This enzyme participates in aminosugars metabolism . This enzyme has at least one effector biology effector , Dithiothreitol . References reflist 1 cite journal author Liau YH, Slomiany BL, Slomiany A, Piasek A, Palmer D, Rosenthal WS date 1985 title Identification of mucus glycoprotein fatty acyltransferase activity in human gastric mucosa journal Digestion. volume 32 pages 57&ndash 62 pmid 4018446 doi 10.1159 000199218 issue 1 transferase stub Category EC 2.3.1 Category Enzymes of unknown structure it Glicoproteina N palmitoiltransferasi ... more details
Hara PJ, Ching AF title Complete cDNA encoding human phospholipid transfer protein from human endothelial ... lipopolysaccharide s from the Bacterial outer membrane outer membrane of Gram negative bacteria ... similarity. ref name pmid10843855 cite journal author Kleiger G, Beamer LJ, Grothe R, Mallick P ... 12887306 doi 10.1042 url ref Cholesteryl ester transfer protein CETP is a glycoprotein that facilitates ... LDL , Very low density lipoprotein VLDL and chylomicrons . These lipoproteins shield the lipid s from ... protein that is secreted from the submucosal gland to the saliva and nasal lavage fluid. PLUNC appears ... content IPR001124 DEFAULTSORT Lipid Binding Serum Glycoprotein Category Protein domains Category ... more details
Tumor associated glycoprotein 72 TAG 72 is a glycoprotein found on the surface of many cancer cells , including ovary , breast , Colon anatomy colon , and pancreatic cells. ref http www.cancer.gov Templates db alpha.aspx?CdrID 45925 TAG 72 antigen entry in the public domain NCI Dictionary of Cancer Terms ref It is a mucin like molecule with a molar mass of over 1000 kDa . ref Cite journal last1 Sheer first1 Donald G. title Purification and Composition of the Human Tumor associated Glycoprotein TAG 72 Defined by Monoclonal Antibodies CC49 and B72.3 journal Cancer Research volume 48 pages 6811 6818 year 1988 pmid 3180090 last2 Schlom first2 J last3 Cooper first3 HL issue 23 ref TAG 72 is a a tumor marker and can be measured with radioimmunoassay s like CA 72 4 , which uses indium 111In satumomab pendetide indium sup 111 sup In satumomab pendetide and Iodine 125I CC49 iodine sup 125 sup I CC49 monoclonal antibody. ref name pmid15138364 Cite journal author Louhimo J, Alfthan H, Stenman UH, Haglund C title Serum HCG beta and CA 72 4 are stronger prognostic factors than CEA, CA 19 9 and CA 242 in pancreatic cancer journal Oncology volume 66 issue 2 pages 126 31 year 2004 pmid 15138364 doi 10.1159 000077438 url http content.karger.com produktedb produkte.asp?typ fulltext&file OCL2004066002126 ref ref name pmid12237895 Cite journal author Louhimo J, Carpelan Holmstr m M, Alfthan H, Stenman UH, J rvinen HJ, Haglund C title Serum HCG beta, CA 72 4 and CEA are independent prognostic factors in colorectal cancer journal Int. J. Cancer volume 101 issue 6 pages 545 8 year 2002 month October pmid 12237895 doi 10.1002 ijc.90009 ref ref name pmid15300805 Cite journal author Louhimo J, Kokkola A, Alfthan H, Stenman UH, Haglund C title Preoperative hCGbeta and CA 72 4 are prognostic factors ... 15300805 doi 10.1002 ijc.20321 ref ref name pmid12118264 Cite journal author Mattar R, Alves de ... glycoprotein 72 mucin levels in tumor and serum of colorectal patients as measured by the quantitative ... more details
Platelet membrane glycoproteins are surface glycoprotein s on platelet s which have a key role in haemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are Receptor biochemistry receptors . ref http cancerweb.ncl.ac.uk cgi bin omd?platelet membrane glycoproteins Platelet membrane glycoprotein on cancerweb.ncl.ac.uk ref References reflist External links http cancerweb.ncl.ac.uk cgi bin omd?platelet membrane glycoproteins Online Medical Dictionary, Platelet membrane glycoproteins MeshName Platelet membrane glycoproteins Category Biochemistry biochem stub Coagulation cs Membr nov glykoproteiny desti ek ... more details
Tumor associated glycoproteins TAGs are glycoprotein s found on the surface of many cancer cells . They are mucin like molecules with a molar mass of over 1000 kDa . ref Cite journal last1 Sheer first1 Donald G. title Purification and Composition of the Human Tumor associated Glycoprotein TAG 72 Defined by Monoclonal Antibodies CC49 and B72.3 journal Cancer Research volume 48 pages 6811 6818 year 1988 pmid 3180090 last2 Schlom first2 J last3 Cooper first3 HL issue 23 ref See also Tumor associated glycoprotein 72 References Reflist Oncology stub Category Glycoproteins Category Tumor markers ... more details
enzyme Name glycoprotein O fatty acyltransferase EC number 2.3.1.142 CAS number 122191 29 1 IUBMB EC number 2 3 1 142 GO code 0047965 image width caption In enzymology , a glycoprotein O fatty acyltransferase EC number 2.3.1.142 is an enzyme that catalysis catalyzes the chemical reaction palmitoyl CoA mucus glycoprotein math rightleftharpoons math CoA O palmitoylglycoprotein Thus, the two substrate biochemistry substrates of this enzyme are palmitoyl CoA and mucus glycoprotein , whereas its two product chemistry products are coenzyme A CoA and O palmitoylglycoprotein . This enzyme belongs to the family of transferase s, specifically those acyltransferase s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is fatty acyl CoA mucus glycoprotein fatty acyltransferase . This enzyme is also called protein acyltransferase . References reflist 1 cite journal author Kasinathan C, Grzelinska E, Okazaki K, Slomiany BL, Slomiany A date 1990 title Purification of protein fatty acyltransferase and determination of its distribution and topology journal J. Biol. Chem. volume 265 pages 5139&ndash 44 pmid 2318887 issue 9 transferase stub Category EC 2.3.1 Category Enzymes of unknown structure it Glicoproteina O acido grasso aciltransferasi ... more details
Infobox protein family Symbol Hema HEFG Name Hemagglutinin domain of haemagglutinin esterase fusion glycoprotein image PDB 1flc EBI.jpg width caption x ray structure of the haemagglutinin esterase fusion glycoprotein of influenza c virus Pfam PF02710 Pfam clan InterPro IPR003860 SMART PROSITE MEROPS SCOP 1flc TCDB OPM family OPM protein CAZy CDD In molecular biology, haemagglutinin esterase fusion glycoprotein HEF is a multi functional protein embedded in the viral envelope of several viruses , including influenza C virus , Coronavirus coronaviruses and torovirus toroviruses . ref name pmid16575523 cite journal author de Groot RJ title Structure, function and evolution of the hemagglutinin esterase proteins of corona and toroviruses journal Glycoconj. J. volume 23 issue 1 2 pages 59 72 year 2006 month February pmid 16575523 doi 10.1007 s10719 006 5438 8 url ref ref name pmid9817207 cite journal author Rosenthal PB, Zhang X, Formanowski F, Fitz W, Wong CH, Meier Ewert H, Skehel JJ, Wiley DC title Structure of the haemagglutinin esterase fusion glycoprotein of influenza C virus journal Nature volume 396 issue 6706 pages 92 6 year 1998 month November pmid 9817207 doi 10.1038 23974 url ref HEF is required for infectivity , and functions to recognise the host cell surface receptor , to fuse the virus viral and host cell membranes , and to destroy the receptor upon host Cell biology cell infection . The haemagglutinin region of HEF is responsible for receptor recognition and membrane fusion, and bears a strong resemblance to the sialic acid binding haemagglutinin found in influenza A and Influenza B B viruses, except that it Molecular binding bind s 9 O acetylsialic acid. The esterase region of HEF is responsible for the destruction of the receptor, an action that is carried out ... I and rhamnogalacturonan acetylesterase . The haemagglutinin esterase glycoprotein HEF must be cleaved ... the host cell. The haemagglutinin esterase glycoprotein is a trimer , where each monomer is composed ... more details
enzyme Name glycoprotein fucosylgalactoside alpha N acetylgalactosaminyltransferase EC number 2.4.1.40 CAS number 9067 69 0 IUBMB EC number 2 4 1 40 GO code 0004380 image width caption In enzymology , a glycoprotein fucosylgalactoside alpha N acetylgalactosaminyltransferase EC number 2.4.1.40 is an enzyme that catalysis catalyzes the chemical reaction UDP N acetyl D galactosamine glycoprotein alpha L fucosyl 1,2 D galactose math rightleftharpoons math UDP glycoprotein N acetyl alpha D galactosaminyl 1,3 alpha L fucosyl 1,2 D galactose Thus, the two substrate biochemistry substrates of this enzyme are UDP N acetyl D galactosamine and glycoprotein alpha L fucosyl 1,2 D galactose , whereas its 3 product chemistry products are uridine diphosphate UDP , glycoprotein N acetyl alpha D galactosaminyl 1,3 alpha L fucosyl , and 1,2 D galactose . This enzyme belongs to the family of transferase s, specifically those glycosyltransferases hexosyltransferases. The systematic name of this enzyme class is UDP N acetyl D galactosamine glycoprotein alpha L fucosyl 1,2 D ga lactose 3 N acetyl D galactosaminyltransferase . Other names in common use include A transferase , histo blood group A glycosyltransferase , Fucalpha1 2Galalpha1 3 N acetylgalactosaminyltransferase , UDP GalNAc Fucalpha1 2Galalpha1 3 N acetylgalactosaminyltransferase , alpha 3 N acetylgalactosaminyltransferase , blood group substance alpha acetyltransferase , blood group substance A dependent acetylgalactosaminyltransferase , fucosylgalactose acetylgalactosaminyltransferase , histo blood group A acetylgalactosaminyltransferase , histo blood group A transferase , UDP N acetyl D galactosamine alpha L fucosyl 1,2 D galactose , and 3 N acetyl D galactosaminyltransferase . This enzyme participates in 3 metabolism metabolic pathways the lactoseries and neolactoseries of glycosphingolipid biosynthesis, as well as the biosynthesis of glycan structures. Structural studies As of late 2007, 19 tertiary structure structures have ... more details
Pfam box Symbol Lamp Name Lysosome associated membrane glycoprotein Lamp image width caption Pfam PF01299 InterPro IPR002000 SMART Prosite PDOC00280 SCOP TCDB 9.A.16 OPM family OPM protein PDB Lysosome associated membrane glycoproteins lamp ref name PUB00002666 cite journal author Fukuda M title Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking journal J. Biol. Chem. volume 266 issue 32 pages 21327 21330 year 1991 pmid 1939168 ref are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome luminal domains separated by a proline rich hinge region at the C terminal extremity there is a transmembrane region TM followed by a very short cytoplasmic tail C . In each of the duplicated domains, there are two conserved disulfide bond s. This structure is schematically represented in the figure below. xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx Hinge TM C In mammals, there are two closely related types of lamp LAMP1 and LAMP2 . CD69 also called gp110 or macrosialin ref name PUB00002833 cite journal author Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL title Macrosialin, a mouse macrophage restricted glycoprotein, is a member of the lamp lgp family journal J. Biol. Chem. volume 268 issue 13 pages 9661 9666 year 1993 pmid 8486654 ref is a heavily glycosylated integral membrane protein whose structure consists of a mucin like domain followed by a proline rich hinge a single lamp like domain a transmembrane region and a short cytoplasmic tail. CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web http mpr.nci.nih.gov prow . Human proteins containing this domain CD68 LAMP1 LAMP2 LAMP3 References reflist Peroxisomal proteins InterPro content IPR002000 Category Protein domains Category Protein families Category Single pass ... more details
. History The us singular form with an i plural comes from Latin. However, the morphology of Latin ... Ancient Greek , from unicode okt pous lang grc , gender masculine, whose plural is unicode ...Most English language English words ending in us, particularly those derived from Latin language Latin ... e.g. campus , plural campuses , anus , plural anuses , are both Latin words that do not pluralize ... with i in Latin are given an i ending in English. Sometimes this plural becomes widely accepted ... are words that, despite not supporting a Latin plural on etymological grounds, are nonetheless widely ... speakers e.g. octopi as a plural for Octopus octopus . The question of whether or not these alternative plural forms can be considered incorrect or not touches on the on going Linguistic prescription ... were from the Latin declension Second declension o second declension grammatical gender masculine ... including their grammatical number number , i.e. whether they are singular or plural using ... with us , and the nominative plural with i . More at Latin grammar . Confusion arises because some ... third declension neuters, such as opus , with the plural opera , and fourth declension masculine ... are bus , a curtailed form of omnibus , a dative plural, and ignoramus , a verb. Virus The English plural of virus is viruses . ref A Dictionary of Modern English Usage 1950 H. W. Fowler, Oxford ... to use the non standard plural in i. However, in computer enthusiast circles in the late 20th ... these non standard plural forms of virus was always a proportionally small percentage of the English ..., combined with the growing awareness that viri and virii are not etymologically supported plural forms ... plural of virus would have been turns out not to be straightforward, as no plural form is attested in extant ... in English &mdash pluralize only under special circumstances, hence the non existence of plural ... ref It is unclear how a plural might have been formed under Latin grammar if the word had acquired ... more details
enzyme Name glycoprotein N acetylgalactosamine 3 beta galactosyltransferase EC number 2.4.1.122 CAS number 97089 61 7 IUBMB EC number 2 4 1 122 GO code 0016263 image width caption In enzymology , a glycoprotein N acetylgalactosamine 3 beta galactosyltransferase EC number 2.4.1.122 is an enzyme that catalysis catalyzes the chemical reaction UDP galactose glycoprotein N acetyl D galactosamine math rightleftharpoons math UDP glycoprotein D galactosyl 1,3 N acetyl D galactosamine Thus, the two substrate biochemistry substrates of this enzyme are UDP galactose and glycoprotein N acetyl D galactosamine , whereas its two product chemistry products are uridine diphosphate UDP and glycoprotein D galactosyl 1,3 N acetyl D galactosamine . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP galactose glycoprotein N acetyl D galactosamine 3 beta D galactosyltransferase . This enzyme is also called uridine diphosphogalactose mucin beta 1 3 galactosyltransferase . This enzyme participates in o glycan biosynthesis and glycan structures biosynthesis 1 . See also C1GALT1 References reflist 1 cite journal author Hesford FJ, Berger EG, Van den Eijnden DH date 1981 title Identification of the product formed by human erythrocyte galactosyltransferase journal Biochim. Biophys. Acta. volume 659 pages 302&ndash 11 pmid 6789880 issue 2 cite journal author Mendicino J, Sivakami S, Davila M, Chandrasekaran EV date 1982 title Purification and properties of UDP gal N acetylgalactosaminide mucin beta 1,3 galactosyltransferase from swine trachea mucosa journal J. Biol. Chem. volume 257 pages 3987&ndash 94 pmid 6801057 issue 7 cite journal author Schachter H, Narasimhan S, Gleeson P, Vella G date 1983 title Glycosyltransferases involved in elongation of N glycosidically linked oligosaccharides of the complex or N acetyllactosamine type journal Methods Enzymol. volume 98 pages 98&ndash 134 pmid 6366476 doi 10.1016 ... more details
Cleanup date February 2011 Merge fromPlural inflection in Western Lombard date July 2009 The general lines of diachronics of Lombard language Lombard and Piedmontese language Piedmontese plural declension are drawn here Feminine In the Lombard languages and in Piedmontese, feminine plural is generally derived from Latin first declension accusative as nouns from other classes first collapsed there some concrete realisations are as a as es e as es ei i as es ei i e as es ei i math emptyset math Masculine On the contrary, masculine plural is generally derived from Latin second declension nominative i this desinence eventually drops or gives rise to palatalisation or metaphonesis some concrete realisations are li lj gl j ni nj gn ti tj cc Metaphonesis in regression orti rt Neutralisation i math emptyset math See also Western Lombard Eastern Lombard Piedmontese Romance plurals References G.Hull the linguistic unity of Northern Italy and Rhaetia, PhD thesis, University of Sidney West 1982 E.Banfi, G.Bonfadini, P.Cordin, M.Iliescu Italia Settentrionale Crocevia di idiomi Romanzi, Atti del convegno internazionale di studi, Trent 21 23 Ottobre 1993 Niemayer, T bingen, 1995 Category Lombard language Category Piedmontese language Category Grammatical number Category Romance languages ie lang stub ... more details
Plural Voices of Macau Voz Plural Gentes de Macau is one of the 16 lists running to the Macanese legislative election, 2009 legislative election of September 2009 in the Macau Special Administrative Region of the Peoples Republic of China. The election occurs once every four years and is the more significant democratic exercise in Macau. The list is made of 12 candidates, the maximum allowed by law. The candidates are from different ethnic backgrounds including Macanese, Portuguese and, for the first time ever, one Filipino. This is the team s first attempt to enter the Legislative Assembly of the Macau SAR, although the list does follow a tradition of broadly Macanese composition that has existed in all prior elections. Casimiro Pinto, a 38 year old Chinese and Portuguese interpreter and translator in the public administration is the first candidate of Voz Plural Gentes de Macau . Jorge Godinho and Jenny Oliveros Lao, both university professors, are the second and third. The other members on the list are respectively Paula Carion, Mario Evora, Isabela Manhao, Rodantes Quejano, Pedro Lobo, Sharoz Pernencar, Guiomar Pedruco, Chiang Tai Chi and Herman Comandante. The political program of the list has stressed namely the need for massive investments in education, health and the administration of justice, as well as the protection of the cultural heritage of Macau. The list has announced that it will carry on civic work after the election, regardless of the results it obtains. See also Politics of Macau Legislative Assembly of Macau Macau legislative election, 2005 External links http www.miro2009.org Official website http www.al.gov.mo Po po main.htm Members of the Assembly of Macau Portuguese http www.al.gov.mo en en.htm Functions 20and 20Powers Legislative Assembly of Macau Macau Legislative Assembly Building http www.macaucloser.com on record.html Macau Closer, A realist with a heart Macanese political parties Category Political parties in Macau ... more details
enzyme Name UDP glucose glycoprotein glucose phosphotransferase EC number 2.7.8.19 CAS number 84861 40 5 IUBMB EC number 2 7 8 19 GO code 0047358 image width caption Orphan date February 2009 In enzymology , an UDP glucose glycoprotein glucose phosphotransferase EC number 2.7.8.19 is an enzyme that catalysis catalyzes the chemical reaction UDP glucose glycoprotein D mannose math rightleftharpoons math UMP glycoprotein 6 D glucose 1 phospho D mannose Thus, the two substrate biochemistry substrates of this enzyme are UDP glucose and glycoprotein D mannose , whereas its two product chemistry products are uridine monophosphate UMP and glycoprotein 6 D glucose 1 phospho D mannose . This enzyme belongs to the family of transferase s, specifically those transferring non standard substituted phosphate groups. The systematic name of this enzyme class is UDP glucose glycoprotein D mannose glucosephosphotransferase . Other names in common use include UDP glucose glycoprotein glucose 1 phosphotransferase , GlcPTase , Glc phosphotransferase , and uridine diphosphoglucose glycoprotein glucose 1 phosphotransferase . References reflist 1 cite journal author Koro LA, Marchase RB date 1982 title A UDP glucose glycoprotein glucose 1 phosphotransferase in embryonic chicken neural retina journal Cell. volume 31 pages 739&ndash 48 pmid 6297779 doi 10.1016 0092 8674 82 90328 2 issue 3 Pt 2 enzyme stub Category EC 2.7.8 Category Enzymes of unknown structure ... more details
infobox Book See Wikipedia WikiProject Novels or Wikipedia WikiProject Books name First Person Plural My Life as a Multiple title orig translator image Image First Person Plural My Life As A Multiple.JPG image caption author Cameron West illustrator cover artist Rebecca Lown country United States language English language English series genre Nonfiction publisher Hyperion publisher Hyperion release date 1999 english release date media type Print Hardcover pages 319 pp first edition, hardback isbn ISBN 0 7868 6390 0 first edition, hardback dewey 616.85 236 0092 B 21 congress RC569.5.M8 W44 1999 oclc 39210166 First Person Plural My Life As A Multiple is a psychology related autobiography written by Dr. Cameron West, who developed dissociative identity disorder as a result of childhood sexual abuse. In it, Dr. West describes his diagnosis, treatment, and personal experiences. Summary West recovers memories of early childhood sexual abuse and is diagnosed with DID as an adult. The book chronicles the first few years of his struggle to accept and heal from his disorder. West describes a system of 24 different personalities that emerge one by one. The presence of personalities is tied to flashbacks West experiences in which he is child molestation molested by his mother and grandmother as well as one or more unidentified male perpetrators. Alters emerge who either hold memories of West s abuse, carry the pain of the experience, or protect West s psyche in one way or another. One personality, named Switch, physically injures West s body in an effort to release pain. Unlike the classic ... from the damage it did to his psyche. One chapter, written entirely from Rikki s point of view, depicts ... a Ph.D. . Analysis West writes First Person Plural using a first person omniscient style, in which ..., until at last he begins to accept that his condition developed to protect him from the psychological ... first Cameron title First Person Plural My Life As a Multiple publisher Hyperion publisher Hyperion ... more details
About the letter R pp move indef small yes Latin alphabet navbox uc R lc rR English alphabet Letter names named ar IPAc en r ref R Oxford English Dictionary , 2nd edition 1989 ar, op. cit. ref is the eighteenth ... background eee Egyptian hieroglyph br tp Phoenician br resh Etruscan R Greek br Rho letter Rho Later Etruscan R hiero D1 hiero File PhoenicianR 01.png File EtruscanR 01.svg 44px File Rho uc lc.svg 60px ... for tp , head . It was used for IPA r by Semites because in their language, the word for head ... R. It is likely that some Etruscan and Western Greek forms of the letter added the extra stroke to distinguish it from a later form of the letter P. Citation needed date February 2012 The minuscule lower case form of r developed through several variations on the capital form. In handwriting it was common ... leg stroke shortened into the simple arc used today. Another minuscule, r rotunda , kept the loop .... Usage See also Rhotic consonant R colored vowel Guttural R In science, the letter R is a symbol for the gas constant . Mathematicians use R or math mathbb R math an R in blackboard bold , displayed as unicode in Unicode for Set mathematics set of all real numbers . R represents a rhotic consonant ... several variations of the letter to represent the different rhotic consonants IPA r represents the alveolar ... width 85 margin auto style width 35 Alveolar trill IPA r style text align center Media alveolar trill.ogg ... language Spanish and Albanian language Albanian r , Turkish language Turkish , Dutch language ... 55 Spanish language Spanish used as an allophone of r in some South American accents Standard Chinese ... Brazilian Portuguese language Portuguese rr Other languages may use the letter r in their alphabets or Latin transliterations schemes to represent rhotic consonants different from the alveolar ... , IPAblink and IPAblink r , the latter three ones can be used only in certain contexts IPAblink and IPAblink r as rr IPAblink in the syllable coda, as an allophone of IPAslink according ... more details
url issn ref Interactions T cell surface glycoprotein CD3 epsilon chain has been shown to Protein ... homologue of the human 20K T3 T cell receptor glycoprotein. journal Nature volume 314 issue ... title Human CD3 epsilon gene contains three miniexons and is transcribed from a non TATA promoter. journal ... derived from thymic precursors. journal Hum. Immunol. volume 43 issue 4 pages 283 94 year 1996 pmid ... envelope glycoprotein gp120. journal AIDS Res. Hum. Retroviruses volume 9 issue 10 pages 945 55 year ..., et al. title Expression of the zeta protein subunit in CD3 NK effectors derived from human thymus ... more details
R is a Logic programming rule based programming language based on C . The United States patent describes R as follows blockquote The R extension permits rules to be defined as members of C classes. The programming system of the invention takes the classes with rules defined using R and generates C code from them in which the machinery required for the rules is implemented completely as C data members and functions of the classes involved in the rules. ref Cite patent US 5768480 Integrating rules into object oriented programming systems ref blockquote R was developed by Bell Labs in the 1990s, but due to the Bell System divestiture that split the legal rights to the work developed at the Laboratories between AT&T and Lucent , did not see immediate commercial development while the two companies disputed ownership. ref cite news url http informationweek.com 807 innovation.htm title Fancy Footwork author Karyl Scott publisher InformationWeek date October 9, 2000 accessdate 2007 01 21 ref References reflist External links http www.cs.bell labs.com cm cs who pfps rpp index.html R official website via Bell Labs compu lang stub Category C programming language family ... more details
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