Infobox Anatomy Name CFU GM Latin GraySubject GrayPage Image Drzewko rozwojowe kom rek macierzystych krwi.JPG Caption Lineage. Captions in Polish, but GMP visible near bottom center. Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Code TerminologiaHistologica 2 00 04.3.02009 CFU GM or GMP , for granulocyte macrophage progenitor is a Hematopoietic stem cell Colony forming units colony forming unit . It is derived from CFU GEMM . The GM stands for granulocyte , monocyte . ref name urlHem I WBC Morphology and Physiology cite web url http www.clt.astate.edu wwilliam hem i wbc morphology and physiology.htm title Hem I WBC Morphology and Physiology work accessdate 2008 12 30 Dead link date October 2010 bot H3llBot ref It is the precursor for monoblast s and myeloblast s. Production is stimulated by granulocyte macrophage colony stimulating factor GM CSF . Granulocytes There is some controversy over which granulocyte s derive from CFU GM. There is little disagreement that neutrophil s come from CFU GM. Some sources state that basophil s also derive from CFU GM, but that eosinophil s come from CFU Eos . ref name isbn0 07 144159 X cite book author Ganong, William F. McPhee, Stephen J. Lingappa, Vishwanath R. title Pathophysiology of Disease An Introduction to Clinical Medicine Lange publisher McGraw Hill Medical location year 2005 pages 107 isbn 0 07 144159 X oclc doi accessdate ref Other sources state that basophils do not derive from CFU GM, but from a distinct CFU, titled CFU Baso . ref name isbn0 8385 8285 0 cite book author Rudolph, Colin David title Rudolph s pediatrics publisher McGraw Hill, Medical Pub. Division location New York year 2003 pages 1563 isbn 0 8385 8285 0 oclc doi accessdate ref See also Hematopoietic stem cell Nomenclature of hematopoietic colonies and lineages References reflist External links MeshName CFU GM Blood Blood physiology Category Colony forming units Category Hematopoietic stem cells Category Blood cells Cell bi ... more details
Infobox disease Name Neutrophil immunodeficiency syndrome Image Alt Caption DiseasesDB ICD10 ICD9 ICDO OMIM 608203 MedlinePlus eMedicineSubj eMedicineTopic MeshID Neutrophil immunodeficiency syndrome is a condition caused by mutations in the Rac2 gene. ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref See also Immunodeficiency with hyper IgM List of cutaneous conditions Chronic granulomatous disease References reflist Dermatology stub Monocyte and granulocyte disease Deficiencies of intracellular signaling peptides and proteins Category Noninfectious immunodeficiency related cutaneous conditions Category Congenital defects of phagocyte number, function, or both ... more details
Multiple issues wikify April 2012 orphan April 2012 Glitter cells are neutrophil s that are found in the urine, most commonly associated with urinary tract infection s and pyelonephritis . They derive their name from their appearance when viewed on a wet mount preparation under a microscope the granules within their cytoplasm can be seen moving, giving them a glittering appearance. ref Ringsrud. http labmed.ascpjournals.org content 32 3 153.full.pdf Cells in the Urine Sediment . Lab Medicine 2001 ref References Reflist blood immune system DEFAULTSORT Neutrophil Granulocyte Category Cell biology Category Granulocytes Category Phagocytes Category Human cells ... more details
Specific granules are secretory Vesicle biology vesicles found exclusively in cells of the immune system called granulocyte s. They are also known as secondary granules . It is sometimes described as applying specifically to neutrophils, ref name urlDefinition specific granule from Online Medical Dictionary cite web url http cancerweb.ncl.ac.uk cgi bin omd?specific granule title Definition specific granule from Online Medical Dictionary format work accessdate ref , and sometimes the term is applied to other types of cells. ref name pmid7334549 cite journal author Okuda M, Takenaka T, Kawabori S, Ogami Y title Ultrastructural study of the specific granule of the human eosinophil journal J. Submicrosc. Cytol. volume 13 issue 3 pages 465 71 year 1981 month July pmid 7334549 doi url ref These granule s store a mixture of cytotoxic molecules, including many enzyme s and antimicrobial peptide s, that are released by a process called degranulation following activation of the granulocyte by an immune stimulus. Specific granules are also known as secondary granules . ref name GreerWintrobe2008 cite book author1 John P. Greer author2 Maxwell Myer Wintrobe title Wintrobe s clinical hematology url http books.google.com books?id 68enzUD7BVgC&pg PA173 accessdate 10 November 2010 date 1 December 2008 publisher Lippincott Williams & Wilkins isbn 9780781765077 pages 173 ref Contents Examples of cytotoxic molecule stored by specific granules in different granulocytes include Neutrophil alkaline phosphatase , lactoferrin , lysozyme , myeloperoxidase , NADPH oxidase Eosinophil cathepsin , major basic protein Basophil heparin , histamine not directly cytotoxic Clinical significance A specific granule deficiency can be associated with CEBPE . ref OMIM 245480 SPECIFIC GRANULE DEFICIENCY SGD ref References reflist External links http nic.sav.sk logos books scientific node16.html Neutrophil granules at sav.sk Granule contents DEFAULTSORT Specific Granule Category Organelles Category Immunol ... more details
Infobox Disease Name Basophilia Image Caption DiseasesDB 29698 ICD10 ICD10 D 75 8 d 70 ICD9 ICD9 288.65 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Basophilia is a condition where the basophil quantity is abnormally elevated more than 10 sup 10 sup basophils per liter of blood . ref cite web url http www.medvet.umontreal.ca clinpath banq im hematology toxic neutrophils.htm title Cytoplasmic basophilia accessdate 2008 09 20 work Veterinary Clinical Pathology Image Database publisher University of Montreal Veterinary College date ref Causes Basophilia as an isolated finding is uncommon. However it is a common feature of myeloproliferative disorders and particularly prominent in chronic myelogenous leukemia . ref cite book title Postgraduate Haematology last Ravandi first F. authorlink coauthors R. Hoffman editor A.V. Hoffbrand et al. year 2005 publisher Blackwell Publishing location Boston isbn 1405108215 chapter Chapter 17. Phagocytes pages 296 298 url ref ref name Kumar12 6 Table 12 6 in cite book author Mitchell, Richard Sheppard Kumar, Vinay Abbas, Abul K. Fausto, Nelson title Robbins Basic Pathology publisher Saunders location Philadelphia year pages isbn 1 4160 2973 7 oclc doi 8th edition. ref References Reflist Monocyte and granulocyte disease Category Cell biology Category Granulocytes Category Human cells Category Monocyte and granulocyte disorders medicine stub hr Bazofilija it Basofilia ... more details
Infobox Disease Name Monocytopenia Image Caption DiseasesDB 29083 ICD10 ICD9 ICD9 288.59 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Monocytopenia is a form of leukopenia associated with a deficiency of monocyte s. The causes of monocytopenia include acute infections, stress, treatment with glucocorticoids, aplastic anemia, hairy cell leukemia, acute myeloid leukemia, treatment with myelotoxic drugs and genetic syndromes. ref Cite book last1 first1 title Harrison s principles of internal medicine. date 2005 publisher McGraw Hill location New York isbn 0 07 140235 7 pages 356 ref It has been proposed as a measure to predict neutropenia , ref name pmid10025393 cite journal author Kondo M, Oshita F, Kato Y, Yamada K, Nomura I, Noda K title Early monocytopenia after chemotherapy as a risk factor for neutropenia journal Am. J. Clin. Oncol. volume 22 issue 1 pages 103 5 year 1999 pmid 10025393 doi 10.1097 00000421 199902000 00025 url http meta.wkhealth.com pt pt core template journal lwwgateway media landingpage.htm?issn 0277 3732&volume 22&issue 1&spage 103 ref though some research indicates that it is less effective than lymphopenia . ref name pmid16651243 cite journal author Oguz A, Karadeniz C, Ckitak EC, Cil V title Which one is a risk factor for chemotherapy induced febrile neutropenia in childhood solid tumors early lymphopenia or monocytopenia? journal Pediatr Hematol Oncol volume 23 issue 2 pages 143 51 year 2006 pmid 16651243 doi 10.1080 08880010500457673 url http www.informaworld.com openurl?genre article&doi 10.1080 08880010500457673&magic pubmed unused data 1B69BA326FFE69C3F0A8F227DF8201D0 ref References reflist Monocyte and granulocyte disease Category Monocyte and granulocyte disorders medicine stub pl Monocytopenia ru ... more details
no footnotes date March 2012 Reticular dysgenesis is a rare genetic disorder of the bone marrow resulting in complete absence of granulocyte s and decreased number of abnormal lymphocyte s. Production of red blood cell s erythrocytes and megakaryocyte s platelet precursors is not affected. There is also poor development of the secondary lymphoid organs. Reticular dysgenesis is the most severe form of severe combined immunodeficiency SCID . The cause of reticular dysgenesis is the inability of granulocyte precursors to form granules secondary to mitochondria l AK2 adenylate kinase 2 malfunction. Further reading cite journal author Bertrand Y, M ller SM, Casanova JL, Morgan G, Fischer A, Friedrich W title Reticular dysgenesis HLA non identical bone marrow transplants in a series of 10 patients journal Bone Marrow Transplant. volume 29 issue 9 pages 759 62 year 2002 month May pmid 12040473 doi 10.1038 sj.bmt.1703531 url http www.nature.com bmt journal v29 n9 full 1703531a.html cite journal author Cham B, Bonilla MA, Winkelstein J title Neutropenia associated with primary immunodeficiency syndromes journal Semin. Hematol. volume 39 issue 2 pages 107 12 year 2002 month April pmid 11957193 cite journal author Emile JF, Geissmann F, Martin OC, et al. title Langerhans cell deficiency in reticular dysgenesis journal Blood volume 96 issue 1 pages 58 62 year 2000 month July pmid 10891430 url http bloodjournal.hematologylibrary.org content 96 1 58.long cite journal author Ohashi Y title Reticular dysgenesis language Japanese journal Ryoikibetsu Shokogun Shirizu volume issue 32 pages 35 7 year 2000 pmid 11212742 med stub Category Rare diseases Category Genetic disorders by system Category Combined T and B cell immunode ciencies Category Noninfectious immunodeficiency related cutaneous conditions ... more details
To help compare different orders of magnitude this page lists volume s between 10 sup 16 sup cubic meters and 10 sup 15 sup cubic meters 100 femtolitre s and 1 picolitre . See also orders of magnitude volume volumes or capacities of other orders of magnitude . 1 E 17 m Volumes less than 100 femtolitres 100 femtolitres Size of an enlarged red blood cell macrocytosis . 200 femtolitres Average volume of a lymphocyte . 330 femtolitres Mean volume of a neutrophil granulocyte . 420 femtolitres Volume of an average monocyte . 1 E 15 m Volumes greater than 1 picolitres References Nibbering, P. H., T. P. L. Zomerdijk, A. J. Cors l Van Tiburg, and R. Van Furth. 1990. Mean cell volume of human blood leucocytes and resident and activated murine macrophages. J. Immunol. Methods 129 143 145 http aac.asm.org cgi external ref?access num 2110946&link type MED . Volume DEFAULTSORT 1 E 16 M Category Orders of magnitude volume ... more details
Unreferenced stub auto yes date December 2009 Orphan date September 2006 att March 2011 Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor cell s. Made available through recombinant DNA technology, they hold tremendous potential for medical uses when a person s natural ability to form blood cells is diminished or defective. Recombinant erythropoietin EPO is very effective in treating the diminished red blood cell production that accompanies end stage kidney disease. Erythropoietin is a sialoglycoprotein hormone produced by peritubular cells of kidney Granulocyte macrophage colony stimulating factor and granulovyte CSF are given to stimulate white blood cell formation in cancer patients who are receiving chemotherapy , which tends to kill their red bone marrow cells as well as the cancer cells. Thrombopoietin shows great promise for preventing platelet depletion during chemotherapy. CSFs and thrombopoietin also improve the outcome of patients who receive bone marrow transplants. DEFAULTSORT Hemopoietic Growth Factors Category Hematopoiesis Category Growth factors Medical stub ... more details
Drugbox Verifiedfields changed verifiedrevid 458270465 image Monoclonal antibody data type mab mab type mab source o target NCA 90 granulocyte antigen Clinical data tradename pregnancy category legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite changed ?? CAS number 250242 54 7 ATC prefix none ATC suffix ATC supplemental PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data chemical formula molecular weight Lemalesomab is a mouse monoclonal antibody for the diagnosis of inflammatory lesion s. ref http whqlibdoc.who.int druginfo DRUG INFO 14 4 2000 INN 84.pdf WHO Drug Information ref References reflist Monoclonals for immune system Category Monoclonal antibodies monoclonal antibody stub antineoplastic drug stub it Lemalesomab ... more details
protein Name colony stimulating factor 2 receptor, beta, low affinity granulocyte macrophage caption image width HGNCid 2436 Symbol CSF2RB AltSymbols IL3RB CD131 EntrezGene 1439 OMIM 138981 RefSeq NM 000395 UniProt P32927 PDB ECnumber Chromosome 22 Arm q Band 12.2 LocusSupplementaryData 13.1 CSF2RB is a common subunit to the following type I cytokine receptor s GM CSF receptor IL 3 receptor IL 5 receptor . ref Woodcock et al., Three residues in the common beta chain of the human GM CSF, IL 3 and IL 5 receptors are essential for GM CSF and IL 5 but not IL 3 high affinity binding and interact with Glu21 of GM CSF. EMBO J. 1994 November 1 13 21 5176 5185. ref References reflist External links MeshName Cytokine Receptor Common beta Subunit Cytokine receptors Clusters of differentiation membrane protein stub ... more details
Expert subject MCB date February 2009 CFU DL is a Hematopoietic stem cell Colony forming units colony forming unit . It gives rise to Langerhans cell s. ref name pmid1383322 cite journal author Reid CD, Stackpoole A, Meager A, Tikerpae J title Interactions of tumor necrosis factor with granulocyte macrophage colony stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34 progenitors in human bone marrow journal J. Immunol. volume 149 issue 8 pages 2681 8 year 1992 month October pmid 1383322 doi url http www.jimmunol.org cgi pmidlookup?view long&pmid 1383322 ref ref name isbn1 4051 2289 7 cite book author Klaus Rabe Stockley, Robert A. Steve Rennard title Chronic Obstructive Pulmonary Disease publisher Blackwell Publishers location Cambridge, MA year 2006 pages 220 isbn 1 4051 2289 7 oclc doi accessdate ref References reflist Blood Category Colony forming units Category Blood cells Cell biology stub ... more details
Josef Arneth 13 October 1873, Burgkunstadt 1955 was a Germany German physician and haematologist known for naming the Arneth count . Biography Josef Arneth was born in 1873 in Burgkunstadt, Upper Franconia . He studied medicine at universities in Ludwig Maximilian University of Munich Munich , University of Heidelberg Heidelberg and University of W rzburg W rzburg , qualifying in 1897. He subsequently worked in W rzburg before becoming professor of medicine in M nster in 1907, a position he held until 1944. He published several books on haematology, and produced research on Neutrophil granulocyte neutrophils and their changes in reaction to infection for which he is remembered. External links WhoNamedIt doctor 278 Josef Arneth Persondata NAME Arneth, Josef ALTERNATIVE NAMES SHORT DESCRIPTION German haematologist DATE OF BIRTH 13 October 1873 PLACE OF BIRTH Burgkunstadt DATE OF DEATH 1955 PLACE OF DEATH DEFAULTSORT Arneth, Josef Category 1873 births Category 1955 deaths Category People from Burgkunstadt Category German physicians Germany med bio stub ... more details
Multiple issues orphan March 2012 unreferenced March 2010 Curaxys is a biopharmaceutical company specializing in the research, development and production of biosimilar generic biological drugs. The company is located in the Technological Park of Puerto de Santa Maria, in Cadiz , Spain . Curaxys has been the pioneer citation needed date December 2011 in the use of insect cells in the production of biosimilar drugs. Previously, the insect cell culture platform was used solely for vaccine production, and never for other therapeutic proteins . citation needed date March 2012 Curaxys is also developing new technological platforms based on such other expression system s as bacteria , virus es and yeast . The company is developing the recombinant proteins Insulin , Growth Hormone , Erythropoietin , and Granulocyte colony stimulating factor GCSF it is also developing the Monoclonal antibody monoclonal antibodies Rituximab and Trastuzumab . Other therapeutic proteins are under development, including non monoclonal antibodies . Category Pharmaceutical companies of Spain ... more details
Neutropenia having too few neutrophils Absolute neutrophil count References reflist Monocyte and granulocyte disease Category Monocyte and granulocyte disorders de Neutrophilie hr Neutrofilija it Neutrofilia ... more details
Colony stimulating factors CSFs are secreted glycoprotein s that bind to receptor proteins on the surfaces of hemopoietic stem cells , thereby activating intracellular signaling pathways that can cause the cells to cell growth proliferate and cellular differentiation differentiate into a specific kind of blood cell usually white blood cells . For red blood cell formation, see erythropoietin . They may be synthesized and administered exogenously. However, such molecules can at a latter stage be detected, since they differ slightly from the endogenous ones in, e.g., features of posttranslational modification . Etymology The name colony stimulating factors comes from the method by which they were discovered. Hemopoietic stem cells were cultured see cell culture on a so called semisolid matrix, which prevents cells from moving around, so that, if a single cell starts proliferating, all of the cells derived from it will remain clustered around the spot in the matrix where the first cell was originally located. These are referred to as colonies. Therefore, it was possible to add various substances to cultures of hemopoietic stem cells and then examine which kinds of colonies if any were stimulated by them. The substance that was found to stimulate formation of colonies of macrophages , for instance, was called macrophage colony stimulating factor , for granulocytes, granulocyte colony stimulating factor, and so on. Mechanism The colony stimulating factors are soluble, in contrast to other, membrane bound substances of the hematopoietic microenvironment . This is sometimes used as the definition of CSFs. They transduce by paracrine , endocrine , or autocrine signaling. Examples Colony stimulating factors include Gene CSF1 macrophage colony stimulating factor Gene CSF2 Granulocyte macrophage colony stimulating factor s also called GM CSF and sargramostim Gene CSF3 Granulocyte colony stimulating factor s also called G CSF and filgrastim Synthetic Promegapoietin Clinical Uses ... more details
a deficiency of neutrophil s the most common granulocyte cell only. To be precise, neutropenia is the term ... terms can be used to specify the type of granulocyte referenced Inadequate numbers of neutrophil .... See also Complete blood count Granulocytosis References reflist Monocyte and granulocyte disease Category Monocyte and granulocyte disorders ar de Agranulozytose fr Agranulocytose ... more details
ref anchor granulocyteGranulocyte deficiency , including decreased numbers of granulocyte s called granulocytopenia or, if absent, agranulocytosis such as of neutrophil granulocyte s termed neutropenia . Granulocyte deficiencies also include decreased function of individual granulocytes, such as in chronic ... fungal infections . ref name Bannister2006 Neutropenia Neutrophil granulocyte s Chemotherapy ..., such as lymphocyte s or granulocyte s. ref cite journal author Rosen FS, Cooper MD, Wedgwood ... more details
Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte . ref name CruseLewis2009 cite book author1 Julius M. Cruse author2 Robert Edwin Lewis title Illustrated dictionary of immunology url http books.google.com books?id X4X8d2SmQB0C&pg PA208 accessdate 24 April 2011 date 20 April 2009 publisher CRC Press isbn 9780849379871 pages 208 ref They are protein mediators typically produced by T cell s to direct the immune system response by signalling between its cells. Lymphokines have many roles, including the attraction of other immune cells, including macrophage s and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response. Circulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is required. Lymphokines aid B cell s to produce antibodies. Important lymphokines secreted by the T helper cell include ref Guyton, AC Hall, JE. 2006 Medical Physiology, Elsevier Saunders. 11th edition, pp.447. ref Interleukin 2 Interleukin 3 Interleukin 4 Interleukin 5 Interleukin 6 Granulocyte macrophage colony stimulating factor Interferon gamma References Reflist External links MeshName Lymphokines eMedicineDictionary lymphokine Cytokines Category Cytokines immunology stub bs Limfokin de Lymphokine es Linfocina sr Limfokin zh ... more details
Anthony Walter Segal born 24 February 1944 is a Great Britain British biochemist. He has been Charles Dent Professor of Medicine, University College London , since 1986. He was educated at the University of Cape Town MB ChB, MD and University of London MSc, DSc, PhD . He was elected a Fellow of the Royal Society in 1998. His recent work is concerned with Crohn s Disease and the role played by neutrophils and granulocyte colony stimulating factor. ref Harbord, MW et al., Aliment Pharmacol Ther. 2006 Aug 15 24 4 651 60 ref References Who s Who UK Who s Who 2006 references Persondata Metadata see Wikipedia Persondata . NAME Segal, Anthony ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 24 February 1944 PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Segal, Anthony Category 1944 births Category Fellows of the Royal Society Category British Jews Category South African Jews Category Jewish scientists Category Living people Category Biochemists Category People associated with University College London Category University of Cape Town alumni UK scientist stub ... more details
protein Name Interleukin 19 caption Crystal structure of human IL 19 image IL19 Crystal Structure.png width 250 px HGNCid 5990 Symbol IL19 AltSymbols , MDA1, ZMDA1, IL 10C EntrezGene 29949 OMIM 605687 RefSeq NM 153758 UniProt Q9UHD0 PDB 1N1F ECnumber Chromosome 1 Arm q Band 32.2 LocusSupplementaryData Interleukin 19 is a cytokine that belongs to the Interleukin 10 IL 10 family of cytokines along with several other interleukin s including interleukin 10 IL 10 , interleukin 20 IL 20 , interleukin 22 IL 22 , interleukin 24 IL 24 , interleukin 26 IL 26 , and several virus encoded cytokines. It signals through the same cell surface receptor IL 20R that is used by IL 20 and IL 24. The IL 19 gene is expressed in resting monocytes and B cells . It is up regulated in monocytes following stimulation with granulocyte macrophage colony stimulating factor GM CSF or lipopolysaccharide . ref Chang, C. et al., Crystal Structure of Interleukin 19 Defines a New Subfamily of Helical Cytokines. Journal of Biological Chemistry , 2003, Volume 278, pages 3308 3313. ref References references interleukins immunology stub it Interleuchina 19 sr 19 ... more details
DISPLAYTITLE Technetium sup 99m sup Tc sulesomab Drugbox Verifiedfields changed verifiedrevid 470478372 drug name Technetium sup 99m sup Tc sulesomab Monoclonal antibody data type mab mab type Fab source o target NCA 90 granulocyte cell antigen Clinical data tradename pregnancy category legal status Approved for use in Australia routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID NA CAS number Ref cascite changed ?? CAS number 167747 19 5 CAS supplemental unlabelled ATC prefix V09 ATC suffix HA04 PubChem DrugBank Ref drugbankcite correct drugbank DrugBank Chemical data chemical formula molecular weight Technetium sup 99m sup Tc sulesomab trade name LeukoScan is a mouse monoclonal antibody ref http whqlibdoc.who.int inn proposed lists prop INN list75.pdf WHO Drug Information ref labelled with technetium 99m , a radionuclide . It is approved for the imaging of infections and inflammations in patients with suspected osteomyelitis , ref http www.emea.europa.eu humandocs PDFs EPAR leukoscan H 111 PI en.pdf EMEA Summary of product characteristics LeukoScan ref and is being investigated for other purposes like the detection of soft tissue infections. ref pmid 18836272 ref References reflist Radiopharmaceuticals Monoclonals for immune system Category Radiopharmaceuticals monoclonal antibody stub antineoplastic drug stub it Sulesomab ... more details
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