enzyme Name GDP glucosidase EC number 3.2.1.42 CAS number 37288 36 1 IUBMB EC number 3 2 1 42 GO code 0047917 image width caption In enzymology , a GDP glucosidase EC number 3.2.1.42 is an enzyme that catalysis catalyzes the chemical reaction GDP glucose H sub 2 sub O math rightleftharpoons math D glucose GDP Thus, the two substrate biochemistry substrates of this enzyme are GDP glucose and water H sub 2 sub O , whereas its two product chemistry products are D glucose and guanosine diphosphate GDP . This enzyme belongs to the family of hydrolase s, specifically those glycosidases that hydrolyse O and S glycosyl compounds. The systematic name of this enzyme class is GDP glucose glucohydrolase . Other names in common use include guanosine diphosphoglucosidase , and guanosine diphosphate D glucose glucohydrolase . References reflist 1 cite journal author Sonnino S, Carminatti H, Cabib E date 1966 title Guanosine diphosphate D glucose glucohydrolase journal Arch. Biochem. Biophys. volume 116 pages 26&ndash 33 pmid 5963308 doi 10.1016 0003 9861 66 90007 5 issue 1 hydrolase stub Category EC 3.2.1 Category Enzymes of unknown structure ... more details
enzyme Name mannose 1 phosphate guanylyltransferase GDP EC number 2.7.7.22 CAS number 9026 31 7 IUBMB EC number 2 7 7 22 GO code 0008928 image width caption Technical date December 2007 In enzymology , a mannose 1 phosphate guanylyltransferase GDP EC number 2.7.7.22 is an enzyme that catalysis catalyzes the chemical reaction GDP alpha D mannose 1 phosphate math rightleftharpoons math phosphate GDP mannose Thus, the two substrate biochemistry substrates of this enzyme are guanosine diphosphate GDP and alpha D mannose 1 phosphate , whereas its two product chemistry products are phosphate and GDP mannose . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is GDP alpha D mannose 1 phosphate guanylyltransferase . This enzyme participates in fructose and mannose metabolism . Other common names GDP mannose phosphorylase Mannose 1 phosphate guanosine diphosphate guanylyltransferase GDP mannose phosphorylase GDP mannose 1 phosphate guanylyltransferase Guanosine diphosphate mannose 1 phosphate guanylyltransferase Guanosine diphosphomannose phosphorylase Mannose 1 phosphate guanylyltransferase GDP D mannose 1 phosphate guanylyltransferase References reflist 1 cite journal author CARMINATTI H, CABIB E date 1961 title Phosphorolysis of the pyrophosphate bond of some nucleotides journal Biochim. Biophys. Acta. volume 53 pages 417&ndash 9 pmid 13876695 doi 10.1016 0006 3002 61 90458 9 issue 2 enzyme stub Category EC 2.7.7 Category Enzymes of unknown structure ... more details
DISPLAYTITLE C sub 10 sub H sub 13 sub N sub 5 sub O sub 5 sub The molecular formula C sub 10 sub H sub 13 sub N sub 5 sub O sub 5 sub may refer to Guanosine 8 Oxo 2 deoxyguanosine MolFormDisambig sr C10H13N5O5 ... more details
enzyme Name galactoside 2 alpha L fucosyltransferase EC number 2.4.1.69 CAS number 56093 23 3 IUBMB EC number 2 4 1 69 GO code 0008107 image width caption In enzymology , a galactoside 2 alpha L fucosyltransferase EC number 2.4.1.69 is an enzyme that catalysis catalyzes the chemical reaction GDP beta L fucose beta D galactosyl R math rightleftharpoons math GDP alpha L fucosyl 1,2 beta D galactosyl R Thus, the two substrate biochemistry substrates of this enzyme are GDP beta L fucose and beta D galactosyl R , whereas its two product chemistry products are guanosine diphosphate GDP and alpha L fucosyl 1,2 beta D galactosyl R . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP beta L fucose beta D galactosyl R 2 alpha L fucosyltransferase . Other names in common use include blood group H alpha 2 fucosyltransferase , guanosine diphosphofucose galactoside 2 L fucosyltransferase , alpha 1 2 L fucosyltransferase , alpha 2 fucosyltransferase , alpha 2 L fucosyltransferase , blood group substance H dependent fucosyltransferase , guanosine diphosphofucose glycoprotein 2 alpha fucosyltransferase , guanosine diphosphofucose lactose fucosyltransferase , GDP fucose lactose fucosyltransferase , guanosine diphospho L fucose lactose fucosyltransferase , guanosine , diphosphofucose beta D galactosyl alpha 2 L fucosyltransferase , guanosine , diphosphofucose , galactosylacetylglucosaminylgalactosylglucosylceramide , alpha L fucosyltransferase , guanosine diphosphofucose glycoprotein 2 alpha L fucosyltransferase , H gene encoded beta galactoside alpha1 2fucosyltransferase , secretor type beta galactoside alpha1 2fucosyltransferase , beta galactoside alpha1 2fucosyltransferase , and GDP L fucose lactose fucosyltransferase . This enzyme participates in 4 metabolism metabolic pathways glycosphingolipid biosynthesis lactoseries , glycosphingolipid biosynthesis neo lactoseries , glycosphingolipid ... more details
Prokaryotic initiation factor 2 is a prokaryotic initiation factor . ref MeshName Prokaryotic Initiation Factor 2 ref IF2 binds to an N Formylmethionine initiator tRNA and controls the entry of that tRNA into the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet tRNA sub f sub binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolysis hydrolyzes Guanosine triphosphate GTP to Guanosine diphosphate GDP and Phosphate P sub i sub , causing a conformational change in the IF2 that causes IF2 to release and allow the 70S subunit to form. References reflist GeneticTranslation GTPases Category Molecular biology Category Protein biosynthesis Category Gene expression ... more details
enzyme Name GDP mannose 3,5 epimerase EC number 5.1.3.18 CAS number 72162 82 4 IUBMB EC number 5 1 3 18 GO code 0047918 image width caption In enzymology , a GDP mannose 3,5 epimerase EC number 5.1.3.18 is an enzyme that catalysis catalyzes the chemical reaction GDP mannose math rightleftharpoons math GDP L galactose Hence, this enzyme has one substrate biochemistry substrate , GDP mannose , and one product chemistry product , GDP L galactose . This enzyme belongs to the family of isomerase s, specifically those racemase s and epimerase s acting on carbohydrate s and derivatives. The systematic name of this enzyme class is GDP mannose 3,5 epimerase . Other names in common use include GDP D mannose GDP L galactose epimerase , guanosine 5 diphosphate D mannose guanosine 5 diphosphate , and L galactose epimerase . This enzyme participates in ascorbate and aldarate metabolism . Structural studies As of late 2007, 4 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2C54 , PDB link 2C59 , PDB link 2C5A , and PDB link 2C5E . References reflist 1 cite journal author Barber GA, Hebda PA date 1982 title GDP D mannose GDP L galactose epimerase from Chlorella pyrenoidosa journal Methods Enzymol. volume 83 pages 522&ndash 5 pmid 7098948 doi 10.1016 0076 6879 82 83046 2 series Methods in Enzymology isbn 9780121819835 cite journal author Hebda PA, Behrman EJ, Barber GA date 1979 title The guanosine 5 diphosphate D mannose guanosine 5 diphosphate L galactose epimerase of Chlorella pyrenoidosa. Chemical synthesis of guanosine 5 diphosphate L galactose and further studies of the enzyme and the reaction it catalyzes journal Arch. Biochem. Biophys. volume 194 pages 496&ndash 502 pmid 443816 doi 10.1016 0003 9861 79 90644 1 issue 2 isomerase stub Category EC 5.1.3 Category Enzymes of known structure ... more details
enzyme Name cellulose synthase GDP forming EC number 2.4.1.29 CAS number 9027 18 3 IUBMB EC number 2 4 1 29 GO code 0016761 image width caption In enzymology , a cellulose synthase GDP forming EC number 2.4.1.29 is an enzyme that catalysis catalyzes the chemical reaction GDP glucose 1,4 beta D glucosyl n math rightleftharpoons math GDP 1,4 beta D glucosyl n sup sup 1 Thus, the two substrate biochemistry substrates of this enzyme are GDP glucose and 1,4 beta D glucosyl n , whereas its two product chemistry products are guanosine diphosphate GDP and 1,4 beta D glucosyl n 1 . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP glucose 1,4 beta D glucan 4 beta D glucosyltransferase . Other names in common use include cellulose synthase guanosine diphosphate forming , cellulose synthetase , guanosine diphosphoglucose 1,4 beta glucan glucosyltransferase , and guanosine diphosphoglucose cellulose glucosyltransferase . This enzyme participates in starch and sucrose metabolism . References reflist 1 cite journal author Chambers J, Elbein AD date 1970 title Biosynthesis of glucans in mung bean seedlings. Formation of beta 1,4 glucans from GDP glucose and beta 1,3 glucans from UDP glucose journal Arch. Biochem. Biophys. volume 138 pages 620&ndash 31 pmid 4317490 doi 10.1016 0003 9861 70 90389 9 issue 2 cite journal author Flowers HM, Batra KK, Kemp J, Hassid WZ date 1969 title Biosynthesis of cellulose in vitro from guanosine diphosphate D glucose with enzymic preparations from Phaseolus aureus and Lupinus albus journal J. Biol. Chem. volume 244 pages 4969&ndash 74 pmid 5824571 issue 18 enzyme stub Category EC 2.4.1 Category Enzymes of unknown structure it GDP glucosio cellulosa glucosiltransferasi ... more details
orphan date January 2010 enzyme Name alpha,alpha trehalose phosphate synthase GDP forming EC number 2.4.1.36 CAS number 37257 32 2 IUBMB EC number 2 4 1 36 GO code 0047260 image width caption In enzymology , an alpha,alpha trehalose phosphate synthase GDP forming EC number 2.4.1.36 is an enzyme that catalysis catalyzes the chemical reaction GDP glucose glucose 6 phosphate math rightleftharpoons math GDP alpha,alpha trehalose 6 phosphate Thus, the two substrate biochemistry substrates of this enzyme are GDP glucose and glucose 6 phosphate , whereas its two product chemistry products are guanosine diphosphate GDP and alpha,alpha trehalose 6 phosphate . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP glucose D glucose 6 phosphate 1 alpha D glucosyltransferase . Other names in common use include GDP glucose glucose phosphate glucosyltransferase , guanosine diphosphoglucose glucose phosphate glucosyltransferase , and trehalose phosphate synthase GDP forming . References reflist 1 cite journal author Elbein AD date 1967 title Carbohydrate metabolism in Streptomyces hygroscopicus . I. Enzymatic synthesis of trehalose phosphate from guanosine diphosphate D glucose 14C journal J. Biol. Chem. volume 242 pages 403&ndash 6 pmid 6022837 issue 3 Category EC 2.4.1 Category Enzymes of unknown structure enzyme stub it Alfa,alfa trealosio fosfato sintasi GDP formante ... more details
enzyme Name fucose 1 phosphate guanylyltransferase EC number 2.7.7.30 CAS number 9033 14 1 IUBMB EC number 2 7 7 30 GO code 0047341 image width caption In enzymology , a fucose 1 phosphate guanylyltransferase EC number 2.7.7.30 is an enzyme that catalysis catalyzes the chemical reaction GTP beta L fucose 1 phosphate math rightleftharpoons math diphosphate GDP L fucose Thus, the two substrate biochemistry substrates of this enzyme are guanosine triphosphate GTP and beta L fucose 1 phosphate , whereas its two product chemistry products are diphosphate and GDP L fucose . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is GTP beta L fucose 1 phosphate guanylyltransferase . Other names in common use include GDP fucose pyrophosphorylase , guanosine diphosphate L fucose pyrophosphorylase , GDP L fucose pyrophosphorylase , GDP fucose pyrophosphorylase , and GTP L fucose 1 phosphate guanylyltransferase . This enzyme participates in fructose and mannose metabolism . References reflist 1 cite journal author Ishihara H, Heath EC date 1968 title The metabolism of L fucose. IV. The biosynthesis of guanosine diphosphate L fucose in porcine liver journal J. Biol. Chem. volume 243 pages 1110&ndash 5 pmid 5646162 issue 6 enzyme stub Category EC 2.7.7 Category Enzymes of unknown structure ... more details
enzyme Name hydroxylysine kinase EC number 2.7.1.81 CAS number 9073 58 9 IUBMB EC number 2 7 1 81 GO code 0047992 image width caption In enzymology , a hydroxylysine kinase EC number 2.7.1.81 is an enzyme that catalysis catalyzes the chemical reaction GTP 5 hydroxy L lysine math rightleftharpoons math GDP 5 phosphonooxy L lysine Thus, the two substrate biochemistry substrates of this enzyme are guanosine triphosphate GTP and 5 hydroxy L lysine , whereas its two product chemistry products are guanosine diphosphate GDP and 5 phosphonooxy L lysine . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is GTP 5 hydroxy L lysine O phosphotransferase . Other names in common use include hydroxylysine kinase phosphorylating , and guanosine triphosphate 5 hydroxy L lysine O phosphotransferase . This enzyme participates in lysine degradation . References reflist 1 cite journal author Hiles RA, Henderson LM date 1972 title The partial purification and properties of hydroxylysine kinase from rat liver journal J. Biol. Chem. volume 247 pages 646&ndash 51 pmid 4621658 issue 3 enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
enzyme Name GDP 6 deoxy D talose 4 dehydrogenase EC number 1.1.1.135 CAS number 37250 66 1 IUBMB EC number 1 1 1 135 GO code 0047916 image width caption In enzymology , a GDP 6 deoxy D talose 4 dehydrogenase EC number 1.1.1.135 is an enzyme that catalysis catalyzes the chemical reaction GDP 6 deoxy D talose NAD P math rightleftharpoons math GDP 4 dehydro 6 deoxy D mannose NAD P H H sup sup The 3 substrate biochemistry substrates of this enzyme are GDP 6 deoxy D talose , nicotinamide adenine dinucleotide NAD sup sup , and nicotinamide adenine dinucleotide phosphate NADP sup sup , whereas its 4 product chemistry products are GDP 4 dehydro 6 deoxy D mannose , nicotinamide adenine dinucleotide NADH , nicotinamide adenine dinucleotide phosphate NADPH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is GDP 6 deoxy D talose NAD P 4 oxidoreductase . This enzyme is also called guanosine diphospho 6 deoxy D talose dehydrogenase . This enzyme participates in fructose and mannose metabolism . References reflist 1 cite journal author Markovitz A year 1964 title Biosynthesis of guanosine diphosphate D rhamnose and guanosine diphosphate D talomethylose from guanosine diphosphate alpha D mannose journal J. Biol. Chem. volume 239 pages 2091&ndash 2098 pmid 14209931 Category EC 1.1.1 Category NADPH dependent enzymes Category NADH dependent enzymes Category Enzymes of unknown structure 1.1.1 enzyme stub it GDP 6 deossi D talosio 4 deidrogenasi ja GDP 6 D 4 ... more details
Unreferenced date December 2009 Nucleotide exchange factor s NEF s are protein s that stimulate the exchange replacement of nucleoside diphosphate s for nucleoside triphosphate s bound to other proteins. Function Many cellular proteins cleave hydrolysis hydrolyze nucleoside triphosphates&ndash adenosine triphosphate ATP or guanosine triphosphate GTP &ndash to their diphosphate forms adenosine diphosphate ADP and guanosine diphosphate GDP as a source of energy and to drive conformational changes. These changes in turn affect the structural, enzyme enzymatic , or signalling properties of the protein. Nucleotide exchange factors actively assist in the exchange of depleted nucleoside diphosphates for fresh nucleoside triphosphates. NEFs are specific for the nucleotides they exchange ADP or GDP, but not both and are often specific to a single protein or class of proteins with which they interact. See also Nucleoside diphosphate kinase Guanine nucleotide exchange factor DEFAULTSORT Nucleotide Exchange Factor Category Proteins Protein stub ... more details
Guanylyl transferases are enzyme s that transfer a guanosine monophosphate GMP also known as guanylic acid group, usually from Guanosine triphosphate GTP to another molecule, releasing pyrophosphate . Many eukaryote eukaryotic guanylyl transferases are capping enzyme s that catalyze the formation of the 5 cap in the co transcriptional modification of messenger RNA . Because the 5 end of the RNA molecule ends in a phosphate group, the bond formed between the RNA and the GTP molecule is an unusual 5 5 triphosphate linkage, instead of the 3 5 linkages between the other nucleotides that form an RNA strand. In capping enzymes, a highly conserved lysine residue serves as the catalytic residue that forms a covalent enzyme GMP complex. ref name Fresco Fresco LD, Buratowski S. 1994 . Active site of the mRNA capping enzyme guanylyltransferase from Saccharomyces cerevisiae similarity to the nucleotidyl attachment motif of DNA and RNA ligases. Proc Natl Acad Sci USA 91 14 6624 6628. ref The transfer RNA tRNA for histidine is unique among eukaryotic tRNAs in requiring the addition of a guanine nucleotide before being aminoacylation aminoacylated by the histidine aminoacyl tRNA synthetase tRNA synthetase . The yeast guanylyl transferase specific to tRNA sup His sup is unique in being the only known non tRNA synthetase enzyme that specifically recognizes the tRNA anticodon . ref name Jackman Jackman JE, Phizicky EM. 2006 . tRNAHis guanylyltransferase adds G 1 to the 5 end of tRNAHis by recognition of the anticodon, one of several features unexpectedly shared with tRNA synthetases. RNA 12 1007 1014. ref Guanylyl transferases also exist for transferring guanosine nucleotides to sugar molecules, such as mannose and fucose . See also mRNA guanylyltransferase External links http www.expasy.org enzyme 2.7.7. EC number 2.7.7. nucleotidyltransferases References reflist transferase stub Kinases Category EC 2.7.7 ... more details
enzyme Name GDP 4 dehydro D rhamnose reductase EC number 1.1.1.187 CAS number 9075 56 3 IUBMB EC number 1 1 1 187 GO code 0042356 image width caption In enzymology , a GDP 4 dehydro D rhamnose reductase EC number 1.1.1.187 is an enzyme that catalysis catalyzes the chemical reaction GDP 6 deoxy D mannose NAD P math rightleftharpoons math GDP 4 dehydro 6 deoxy D mannose NAD P H H sup sup The 3 substrate biochemistry substrates of this enzyme are GDP 6 deoxy D mannose , nicotinamide adenine dinucleotide NAD sup sup , and nicotinamide adenine dinucleotide phosphate NADP sup sup , whereas its 4 product chemistry products are GDP 4 dehydro 6 deoxy D mannose , nicotinamide adenine dinucleotide NADH , nicotinamide adenine dinucleotide phosphate NADPH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is GDP 6 deoxy D mannose NAD P 4 oxidoreductase . Other names in common use include GDP 4 keto 6 deoxy D mannose reductase , GDP 4 keto D rhamnose reductase , and guanosine diphosphate 4 keto D rhamnose reductase . This enzyme participates in fructose and mannose metabolism . References reflist 1 cite journal author Barber GA date 1968 title The synthesis of guanosine 5 diphosphate D rhamnose by enzymes of a higher plant journal Biochim. Biophys. Acta. volume 165 pages 68&ndash 75 pmid 4386238 issue 1 cite journal author Winkler NW, Markovitz A date 1971 title Guanosine diphosphate 4 keto D rhamnose reductase. A non stereoselective enzyme journal J. Biol. Chem. volume 246 pages 5868&ndash 76 pmid 4398966 issue 19 1.1.1 enzyme stub Category EC 1.1.1 Category NADPH dependent enzymes Category NADH dependent enzymes Category Enzymes of unknown structure it GDP 4 deidro D ramnosio reduttasi ja GDP 4 D ... more details
enzyme Name GTP cyclohydrolase II EC number 3.5.4.25 CAS number 56214 35 8 IUBMB EC number 3 5 4 25 GO code 0003935 image width caption In enzymology , a GTP cyclohydrolase II EC number 3.5.4.25 is an enzyme that catalysis catalyzes the chemical reaction GTP 3 H sub 2 sub O math rightleftharpoons math formate 2,5 diamino 6 hydroxy 4 5 phosphoribosylamino pyrimidine diphosphate Thus, the two substrate biochemistry substrates of this enzyme are guanosine triphosphate GTP and water H sub 2 sub O , whereas its 3 product chemistry products are formate , 2,5 diamino 6 hydroxy 4 5 phosphoribosylamino pyrimidine , and diphosphate . This enzyme belongs to the family of hydrolase s, those acting on carbon nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is GTP 7,8 8,9 dihydrolase diphosphate forming . Other names in common use include guanosine triphosphate cyclohydrolase II , and GTP 8 formylhydrolase . This enzyme participates in riboflavin metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2BZ0 and PDB link 2BZ1 . References reflist 1 cite journal author Foor F, Brown GM date 1975 title Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli journal J. Biol. Chem. volume 250 pages 3545&ndash 51 pmid 235552 issue 9 hydrolase stub Category EC 3.5.4 Category Enzymes of known structure ... more details
enzyme Name GDP mannose 4,6 dehydratase EC number 4.2.1.47 CAS number 37211 59 9 IUBMB EC number 4 2 1 47 GO code 0008446 image width caption In enzymology , a GDP mannose 4,6 dehydratase EC number 4.2.1.47 is an mannosyltransferase enzyme that catalysis catalyzes the chemical reaction GDP mannose math rightleftharpoons math GDP 4 dehydro 6 deoxy D mannose H sub 2 sub O Hence, this enzyme has one substrate biochemistry substrate , GDP mannose , and two product chemistry products , GDP 4 dehydro 6 deoxy D mannose and water H sub 2 sub O . This enzyme belongs to the family of lyase s, specifically the hydro lyases, which cleave carbon oxygen bonds. The systematic name of this enzyme class is GDP mannose 4,6 hydro lyase GDP 4 dehydro 6 deoxy D mannose forming . Other names in common use include guanosine 5 diphosphate D mannose oxidoreductase , guanosine diphosphomannose oxidoreductase , guanosine diphosphomannose 4,6 dehydratase , GDP D mannose dehydratase , GDP D mannose 4,6 dehydratase , Gmd , and GDP mannose 4,6 hydro lyase . This enzyme participates in fructose and mannose metabolism. It employs one cofactor biochemistry cofactor , NAD . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1DB3 , PDB link 1N7G , PDB link 1N7H , PDB link 1RPN , and PDB link 1T2A . References reflist 1 cite journal author Elbein AD and Heath EC date 1965 title THE BIOSYNTHESIS OF CELL WALL LIPOPOLYSACCHARIDE IN ESCHERICHIA COLI. II. GUANOSINE DIPHOSPHATE 4 KETO 6 DEOXY D MANNOSE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE COLITOSE journal J. Biol. Chem. volume 240 pages 1926&ndash 31 pmid 14299611 cite journal author Liao TH, Barber GA date 1972 title Purification of guanosine 5 diphosphate D mannose oxidoreductase from Phaseolus vulgaris journal Biochim. Biophys. Acta. volume 276 pages 85&ndash 93 pmid 5047712 issue 1 cite journal author Melo A, Elliott W ... more details
Unreferenced date December 2009 Chembox verifiedrevid 447288204 ImageFile DGDP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo PubChem 644 SMILES C1C C OC1N2C NC3 C2NC NC3 O N COP O O OP O O O O Section2 Chembox Properties Formula C sub 10 sub H sub 15 sub N sub 5 sub O sub 10 sub P sub 2 sub MolarMass 427.201122 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxyguanosine diphosphate is a nucleoside diphosphate . It is related to the common nucleic acid GTP, or guanosine triphosphate , with the OH hydroxyl group on the 2 carbon on the nucleotide s pentose removed hence the deoxy part of the name , and with one fewer phosphoryl group than GTP. Deoxyguanosine diphosphate is abbreviated dGDP. See also Nucleic acid DNA metabolism Cofactor biochemistry Cofactor Guanosine Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxyguanosine Diphosphate Category Nucleotides ca Difosfat de desoxiguanosina fa gl Desoxiguanosina difosfato nl Deoxyguanosinedifosfaat sr Dezoksiguanozin difosfat zh ... more details
Unreferenced date October 2006 Chembox verifiedrevid 447289738 ImageFile Desoxyguanosinmonophosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 902 04 5 PubChem 161075 SMILES C1C C OC1N2C NC3 C2NC NC3 O N COP O O O O.N Section2 Chembox Properties Formula C sub 10 sub H sub 14 sub N sub 5 sub O sub 7 sub P MolarMass 347.2243 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxyguanosine monophosphate , also known as deoxyguanylate , or dGMP , is a derivative of the common nucleic acid guanosine triphosphate GTP , in which the OH hydroxyl group on the 2 carbon on the nucleotide s pentose has been reduced to just a hydrogen atom hence the deoxy part of the name . It is used as a monomer in DNA . See also Nucleic acid DNA metabolism Cofactor biochemistry Cofactor Guanosine Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxyguanosine Monophosphate Category Nucleotides ca Monofosfat de desoxiguanosina fa fr D soxyguanosine monophosphate gl Desoxiguanosina monofosfato nl Deoxyguanosinemonofosfaat sr Dezoksiguanozin monofosfat zh ... more details
enzyme Name heteroglycan alpha mannosyltransferase EC number 2.4.1.48 CAS number 37277 57 9 IUBMB EC number 2 4 1 48 GO code 0047264 image width caption In enzymology , a heteroglycan alpha mannosyltransferase EC number 2.4.1.48 is an enzyme that catalysis catalyzes the chemical reaction GDP mannose heteroglycan math rightleftharpoons math GDP 2 or 3 alpha D mannosyl heteroglycan Thus, the two substrate biochemistry substrates of this enzyme are GDP mannose and heteroglycan , whereas its 3 product chemistry products are guanosine diphosphate GDP , 2 alpha D mannosyl heteroglycan , and 3 alpha D mannosyl heteroglycan . This enzyme belongs to the family of glycosyltransferase s, to be specific the hexosyltransferases. The systematic name of this enzyme class is GDP mannose heteroglycan 2 or 3 alpha D mannosyltransferase . Other names in common use include GDP mannose alpha mannosyltransferase , and guanosine diphosphomannose heteroglycan alpha mannosyltransferase . References reflist 1 cite journal author Garancis JC, Ankel H, Ankel E, Schutzbach JS date 1970 title Mannosyl transfer in Cryptococcus laurentii journal J. Biol. Chem. volume 245 pages 3945&ndash 55 pmid 5492958 issue 15 enzyme stub Category EC 2.4.1 Category Enzymes of unknown structure it Eteroglicano alfa mannosiltransferasi ... more details
enzyme Name undecaprenyl phosphate mannosyltransferase EC number 2.4.1.54 CAS number 37277 62 6 IUBMB EC number 2 4 1 54 GO code 0047267 image width caption In enzymology , an undecaprenyl phosphate mannosyltransferase EC number 2.4.1.54 is an enzyme that catalysis catalyzes the chemical reaction GDP mannose undecaprenyl phosphate math rightleftharpoons math GDP D mannosyl 1 phosphoundecaprenol Thus, the two substrate biochemistry substrates of this enzyme are GDP mannose and undecaprenyl phosphate , whereas its two product chemistry products are guanosine diphosphate GDP and D mannosyl 1 phosphoundecaprenol . This enzyme belongs to the family of glycosyltransferase s, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP mannose undecaprenyl phosphate D mannosyltransferase . Other names in common use include guanosine diphosphomannose undecaprenyl phosphate , mannosyltransferase , GDP mannose undecaprenyl phosphate mannosyltransferase , and GDP D mannose lipid phosphate transmannosylase . It employs one cofactor biochemistry cofactor , phosphatidylglycerol . References reflist 1 cite journal author Lahav M, Chiu TH, Lennarz WJ date 1969 title Studies on the biosynthesis of mannan in Micrococcus lysodeikticus II. The enzymatic synthesis of mannosyl l phosphoryl undecaprenol journal J. Biol. Chem. volume 244 pages 5890&ndash 8 pmid 5350943 issue 21 enzyme stub Category EC 2.4.1 Category Enzymes of unknown structure it Undecaprenil fosfato mannosiltransferasi ... more details
enzyme Name glucose 1 phosphate guanylyltransferase EC number 2.7.7.34 CAS number 9033 13 0 IUBMB EC number 2 7 7 34 GO code 0047344 image width caption In enzymology , a glucose 1 phosphate guanylyltransferase EC number 2.7.7.34 is an enzyme that catalysis catalyzes the chemical reaction GTP alpha D glucose 1 phosphate math rightleftharpoons math diphosphate GDP glucose Thus, the two substrate biochemistry substrates of this enzyme are guanosine triphosphate GTP and alpha D glucose 1 phosphate , whereas its two product chemistry products are diphosphate and GDP glucose . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing nucleotide groups nucleotidyltransferase s . The systematic name of this enzyme class is GTP alpha D glucose 1 phosphate guanylyltransferase . Other names in common use include GDP glucose pyrophosphorylase , and guanosine diphosphoglucose pyrophosphorylase . This enzyme participates in starch and sucrose metabolism . References reflist 1 cite journal author Danishefsky I, Heritier Watkins O date 1967 title Nucleoside diphosphate glucose pyrophosphorylases in mast cell tumors journal Biochim. Biophys. Acta. volume 139 pages 349&ndash 57 pmid 6034677 issue 2 enzyme stub Category EC 2.7.7 Category Enzymes of unknown structure ... more details
enzyme Name phosphoglycerate kinase GTP EC number 2.7.2.10 CAS number 62213 34 7 IUBMB EC number 2 7 2 10 GO code 0050191 image width caption In enzymology , a phosphoglycerate kinase GTP EC number 2.7.2.10 is an enzyme that catalysis catalyzes the chemical reaction GTP 3 phospho D glycerate math rightleftharpoons math GDP 3 phospho D glyceroyl phosphate Thus, the two substrate biochemistry substrates of this enzyme are guanosine triphosphate GTP and 3 phospho D glycerate , whereas its two product chemistry products are guanosine diphosphate GDP and 3 phospho D glyceroyl phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with a carboxy group as acceptor. The systematic name of this enzyme class is GTP 3 phospho D glycerate 1 phosphotransferase . References reflist 1 cite journal author Reeves RE, South DJ date 1974 title Phosphoglycerate kinase GTP . An enzyme from Entamoeba histolytica selective for guanine nucleotides journal Biochem. Biophys. Res. Commun. volume 58 pages 1053&ndash 7 pmid 4365563 doi 10.1016 S0006 291X 74 80250 0 issue 4 enzyme stub Category EC 2.7.2 Category Enzymes of unknown structure ... more details
enzyme Name phosphomannan mannosephosphotransferase EC number 2.7.8.9 CAS number 37278 31 2 IUBMB EC number 2 7 8 9 GO code 0047361 image width caption In enzymology , a phosphomannan mannosephosphotransferase EC number 2.7.8.9 is an enzyme that catalysis catalyzes the chemical reaction GDP mannose phosphomannan n math rightleftharpoons math GMP phosphomannan n sup sup 1 Thus, the two substrate biochemistry substrates of this enzyme are GDP mannose and phosphomannan n , whereas its two product chemistry products are guanosine monophosphate GMP and phosphomannan n 1 . This enzyme belongs to the family of transferase s, specifically those transferring non standard substituted phosphate groups. The systematic name of this enzyme class is GDP mannose phosphomannan mannose phosphotransferase . References reflist 1 cite journal author Bretthauer RK, Kozak LP, Irwin WE date 1969 title Phosphate and mannose transfer from guanosine diphosphate mannose to yeast mannan acceptors journal Biochem. Biophys. Res. Commun. volume 37 pages 820 827 pmid 4311996 doi 10.1016 0006 291X 69 90965 6 issue 5 enzyme stub Category EC 2.7.8 Category Enzymes of unknown structure ... more details
The Purine Nucleotide Cycle is a metabolic pathway in which fumarate is generated from aspartate in order to increase the concentration of Krebs cycle intermediates. ref Salway, J. G., Metabolism at a glance 3rd edition , Blackwell Publishing Ltd., Oxford, 2004, pp. 56 57 ref The pathway was first described by John Lowenstein, who demonstrated its role in increasing the rate of oxidative phosphorylation in skeletal muscle . ref Voet, D., Voet, J. G., Biochemistry 3rd Edition , John Wiley & Sons, Inc., 2004, pp. 1094 1095 ref Outline The cycle is composed of three Enzyme enzyme catalysed reactions. The first stage is the deamination of the purine nucleotide Adenosine monophosphate AMP to form inosine monophosphate IMP , catalysed by the enzyme AMP deaminase AMP H sub 2 sub O IMP NH sub 4 sub sup sup The second stage is the formation of adenylosuccinate from IMP and the amino acid aspartate , which is coupled to the energetically favourable hydrolysis of Guanosine triphosphate GTP , and catalysed by the enzyme adenylosuccinate synthetase Aspartate IMP GTP Adenylosuccinate Guanosine diphosphate GDP Inorganic phosphate P sub i sub Finally, Adenylosuccinate is cleaved by the enzyme adenylosuccinate lyase to release fumarate and regenerate the starting material of AMP Adenylosuccinate AMP Fumarate References ISBN Reflist Category Purines Category Metabolic pathways Category Biochemistry fr Cycle des nucl otides puriques zh ... more details
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