Hematopathology is the branch of pathology which studies diseases of hematopoietic cells hematopathology Diseases of Hematopoietic Cells see below . In the United States, hematopathology is a board certified subspecialty American Board of Pathology practiced by those physicians who have completed general pathology residency anatomic, clinical, or combined and additional fellowship training in hematology. Hematopoietic cells originate from the bone marrow and contribute the cellular components of blood including red blood cells erythrocytes , white blood cells leukocytes , and platelets megakaryocyte derived bodies . Additionally, leukocytes contribute significantly to the cellular composition of lymph nodes, the spleen, the thymus, and mucosa associated lymphoid tissues, and are present to some degree in all tissues. Diseases of the hematopoietic system generally manifest as decreases anemia or increases lymphoma leukemia in these cell types. Consequently, hematopathologists most frequently evaluate peripheral blood smears , bone marrow aspirates and biopsy biopsies , and lymph nodes biopsies to determine the nature of hematopoietic disease. The hematopathologist incorporates traditional microscopy with ancillary techniques including general laboratory values , immunohistochemistry , flow cytometry , and molecular diagnostic tests to make the most accurate medical diagnosis diagnosis . The hematopathologist works closely with the hematologist oncologist specialty physician doctor who sees the patient and decides on the best treatment based upon the medical diagnosis diagnosis made by the hematopathologist. Diseases of Hematopoietic Cells Diseases of the hematopoietic system are myriad and include hereditary and congenital disorders as well as acquired disorders. Hereditary and congenital disorders include, in part, bone marrow failure syndromes and primary immune deficiency ... relapse. Category Hematopathology ... more details
Infobox Disease Name PAGENAME Image Myeloblast.png Caption Myeloblast DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D015470 Acute myeloblastic leukemia is a form of myeloid leukemia affecting myeloblast s. More specifically, it can refer to Minimally differentiated acute myeloblastic leukemia M0 in French American British classification FAB ICDO 9872 3 Acute myeloblastic leukemia without maturation M1 in French American British classification FAB ICDO 9873 3 Acute myeloblastic leukemia with maturation M2 in French American British classification FAB ICDO 9874 3 See also Acute myeloid leukemia Myeloid malignancy oncology stub Category Hematopathology Category Acute leukemia da Akut myeloid leuk mi ru zh ... more details
Prussian blue is a common stain used by pathologist s to detect the presence of iron in biopsy specimens, such as deposits of storage ferritin in bone marrow biopsy samples. The original stain formula, known historically 1867 as Perls Prussian blue after its inventor, German pathologist Max Perls 1843 1881 , used separate solutions of potassium ferrocyanide and acid to stain tissue these are now used combined, just before staining . Iron deposits in tissue then form the insoluble Prussian blue dye a complex hydrated ferric ferrocyanide substance in place, and are visualized the microscopically as blue or purple deposits within cells. ref http www.scribd.com doc 4448747 Perl Formula for Perls Prussian blue stain. Accessed April 2, 2009. ref The formula is also known as Perls Prussian blue and incorrectly as Perl s Prussian blue. References reflist pathology Category Anatomical pathology Category Histopathology Category Hematopathology pathology stub ... more details
Infobox Anatomy Name Accessory visual structures Latin structurae oculi accessoriae GraySubject GrayPage Image Eyes chris.jpg Caption An unmodified male eyebrow and eye Image2 Gray892.png Caption2 Front of left eye with eyelids separated. Precursor System Artery Vein Nerve Lymph MeshName MeshNumber Accessory visual structures is a term used to collectively refer to the adnexa of the human eye eye . Included are the eyebrow , eyelid s, and lacrimal apparatus . One source defines ocular adnexa as the Orbit anatomy orbit , conjunctiva , and eyelid s. ref name isbn0 683 30246 9 cite book author Knowles, Daniel M. title Neoplastic hematopathology publisher Lippincott Williams & Wilkins location Hagerstwon, MD year 2001 pages 1303 isbn 0 683 30246 9 oclc doi accessdate ref References reflist Accessory organs of the eye Category Eye anatomy anatomy stub ... more details
Juvenile megaloblastic anaemia 1 Imerslund Grasbeck syndrome is a disease caused by selective cobalamin malabsorption and inconstant proteinuria. It is caused by mutations in the cubilin CUBN or amnionless AMN genes. ref name Namour2011 Namour F, Dobrovoljski G, Chery C, Audonnet S, Feillet F, Sperl W, Gueant JL 2011 Luminal expression of cubilin is impaired in Imerslund Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7. Haematologica ref Pathophysiology The protein cubilin binds to intrinsic factor cobalamin complex and is expressed in the distal small intestine and proximal renal tubule. Amnionless is a transmembrane protein that binds tightly to the N terminal end of cubilin. Together these proteins form the multiligand cubam compex. Mutations in these genes may cause a decrease in the uptake of vitamin B12 leading to megaloblastic anemia megaloblastic anaemia . References reflist Hematology DEFAULTSORT Juvenile megaloblastic anaemia 1 Category Nutritional anemias Category Hematopathology ... more details
Infobox Disease Name Macrocytosis Image Caption DiseasesDB 7688 ICD10 ICD10 D 75 8 d 70 ICD9 ICD9 289.89 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 1381 MeshName MeshNumber Macrocytosis is the enlargement of red blood cell s with near constant hemoglobin concentration, and is defined by a mean corpuscular volume MCV of greater than 100 femtolitres the precise criterion varies between laboratories . Causes Most commonly especially when the increase in size is mild, and just above normal range the etiology is bone marrow dysplasia secondary to alcohol abuse and Chronic alcoholism . Other causes may include Megaloblastosis Vitamin B12 or folate deficiency or DNA synthesis inhibiting drugs hypothyroidism reticulocytosis commonly from hemolysis or a recent history of blood loss . liver disease myeloproliferative disease Pregnancy is the most common and requires no treatment as female will return back to normal post partum Complications No complications arise from macrocytosis itself and a prognosis will be determined from its etiology . See also Macrocytic anemia pathology stub Myeloid hematologic disease Abnormal clinical and laboratory findings Alcohol and health Category Hematopathology Category Abnormal clinical and laboratory findings for RBCs it Macrocito ... more details
Nancy Lee Harris is the Austin L. Vickery Jr. Professor of Pathology at Harvard Medical School . She is also a physician at Massachusetts General Hospital and an editor with the New England Journal of Medicine . Harris has a BA in English from Stanford University and an MD from Stanford Medical School . She did her internship at Barnes Hospital in St. Louis and then a research fellowship in hematopathology at Massachusetts General Hospital. She is the wife of Jay R. Harris, who is a radiation oncology professor at Harvard Medical School. Their son Matt C. Harris Matthew Carmichael Harris , a venture capitalist, married filmmaker Jessica Glass whose father, Joseph Glass, was a hematologist and oncologist and the director of hematology at Lenox Hill Hospital . Their second son, Dan Harris journalist Dan Harris , is the co anchor of the weekend edition of Good Morning America . Sources http www.massachusettsgeneralhospital.com doctors doctor.aspx?ID 16616 Massachusetts General Hosptial bio of Harris http www.nytimes.com 2004 10 10 fashion weddings 10GLAS.html New York Times , Oct. 10, 2004 article on the marriage of Matthew Harris and Jessica Glass Persondata Metadata see Wikipedia Persondata . NAME Harris, Nancy Lee ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Harris, Nancy Lee Category Living people Category Harvard Medical School faculty Category Stanford Medical School alumni Category Stanford University alumni Category American pathologists ... more details
Infobox disease Name Splenic tumor Image Alt Caption DiseasesDB ICD10 C26.1, D13.9 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID A splenic tumor is a rare form of tumor that may be malignant or benign. Malignant forms include lymphoma and sarcoma . ref name Bisset2008 cite book author Bisset title Differential Diagnosis in Abdominal Ultrasound, 3 e url http books.google.com books?id pw5uaOu7PJEC&pg PT208 accessdate 22 May 2011 date 1 January 2008 publisher Elsevier India isbn 9788131215746 pages 208 ref Lymphoma is the most common malignant splenic tumor. ref name DalrympleLeyendecker2009 cite book author1 Neal C. Dalrymple author2 John R. Leyendecker author3 Michael Oliphant title Problem Solving in Abdominal Imaging url http books.google.com books?id JeaQXWu7Sz0C&pg PA410 accessdate 22 May 2011 date 12 June 2009 publisher Elsevier Health Sciences isbn 9780323043533 pages 410 ref References reflist Lymphatic organ neoplasia Category Lymphatic organ neoplasia Category Hematopathology Category Lymphoma medicine stub ... more details
Normocytic anemia is a common issue that occurs for men and women typically over 85 years old. Its prevalence increases with age, reaching 44 percent in men older than 85 years. ref name AAFP cite journal author Brill JR, Baumgardner DJ title Normocytic anemia journal Am Fam Physician volume 62 issue 10 pages 2255 64 year 2000 month November pmid 11126852 doi url http www.aafp.org afp 20001115 2255.html ref Normocytic anemia is the most frequently encountered type of anemia. ref name AAFP Classification A normocytic anemia is defined as an anemia with an Mean corpuscular volume MCV of 80 100. Causes The issue is thought of as representing any of the following a decreased production of normal sized red blood cells e.g., anemia of chronic disease, aplastic anemia an increased production of HbS as seen in sickle cell disease not sickle cell trait an increased destruction or loss of red blood cells e.g., hemolysis, posthemorrhagic anemia an uncompensated increase in Blood plasma plasma volume e.g., pregnancy , fluid overload a B2 riboflavin deficiency ref Medical Physiolgy by Kibble and Halsey p295 ref a B6 pyridoxine deficiency ref Medical Physiolgy by Kibble and Halsey p295 ref or a mixture of conditions producing microcytic anemia microcytic and macrocytic anemia . ref name AAFP References reflist Myeloid hematologic disease External links Normocytic Anemia http www.aafp.org afp 20001115 2264ph.html Normocytic Anemia American Family Physician http findarticles.com p articles mi m3225 is ai 67164191 Category Anemias Category Hematopathology medical stub ca An mia normoc tica sq Anemia normocitike sl Normocitna anemija sv Normocyt r anemi ... more details
Hematocrit math A value of 45 is usually used as a normal hematocrit. ref name urlUAB Hematopathology cite web url http peir.path.uab.edu heme messages 637 648.html title UAB Hematopathology format work ... more details
Infobox Disease Name Myelophthisic anemia Image Caption DiseasesDB ICD10 ICD10 D 61 9 d 60 ICD9 ICD9 284.2 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 1562 MeshID D000750 Myelophthisic anemia or myelophthisis is a severe kind of anemia found in some people with diseases that affect the bone marrow . Myelophythisis refers to the displacement of hemopoietic bone marrow tissue into the peripheral blood, ref name urlHematopathology cite web url http library.med.utah.edu WebPath HEMEHTML HEME030.html title Hematopathology format work accessdate ref either by fibrosis , tumor s or granuloma s. Causes Myelophythisis can occur in the setting of chronic myeloproliferative disease e.g. myelofibrosis , leukemia , lymphoma , and metastatic carcinoma or myeloma . It is common in people who have chronic idiopathic myelofibrosis. It has been linked to small cell lung cancer, breast cancer or prostate cancer that metastasizes to the bone marrow. ref name AmericanSociety American Society of hematology self assessment program, second edition, 2005, page 82. ref Diagnosis The first test for diagnosis myelophthisis involves looking at a small sample of blood under a microscope. Myelophthisis is suggested by the presence of red blood cells that contain cell nucleus nuclei or are teardrop shaped dacryocytes , or immature granulocyte precursor cells which indicates leukoerythroblastosis is occurring because the displaced hematopoietic cells begin to undergo extramedullary hematopoiesis. These immature granulocytes are seen in peripheral blood smears. Diagnosis is confirmed when a bone marrow biopsy demonstrates significant replacement of the normal bone marrow compartment by fibrosis, malignancy or other infiltrative process. The presence of immature blood cell precursors helps distinguish another cause of pancytopenia , aplastic anemia , from myelophthisic anemia because in aplastic anemia the hematopoietic cells are damaged and immature blood cells are not seen in the periphe ... more details
Refimprove date January 2009 Infobox Disease Name PAGENAME Image Caption DiseasesDB 33778 ICD10 ICD10 L 41 2 l 40 ICD9 ICDO 9718 1 OMIM MedlinePlus eMedicineSubj derm eMedicineTopic 254 MeshID D017731 Lymphomatoid papulosis LyP is a rare skin disorder . The overall prevalence rate of lymphomatoid papulosis is estimated at 1.2 to 1.9 cases per 1,000,000 population. This rare condition has only been studied in depth since 1968. ref name pmid5634442 cite journal author Macaulay WL title Lymphomatoid papulosis. A continuing self healing eruption, clinically benign histologically malignant journal Arch Dermatol volume 97 issue 1 pages 23 30 year 1968 month January pmid 5634442 doi 10.1001 archderm.97.1.23 url ref Presentation It can appear very similar to anaplastic large cell lymphoma . ref name pmid15096372 cite journal author El Shabrawi Caelen L, Kerl H, Cerroni L title Lymphomatoid papulosis reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C journal Arch Dermatol volume 140 issue 4 pages 441 7 year 2004 month April pmid 15096372 doi 10.1001 archderm.140.4.441 url http archderm.ama assn.org cgi pmidlookup?view long&pmid 15096372 ref Type A is CD30 positive, while type B is CD30 negative. ref name YoungGerson2006 cite book author1 Neal S. Young author2 Stanton L. Gerson author3 Katherine A. High title Clinical hematology url http books.google.com books?id LY93 9iBb IC&pg PA555 accessdate 14 May 2011 year 2006 publisher Elsevier Health Sciences isbn 9780323019088 pages 555 ref It has been described as clinically benign but histologically malignant. ref name Proytcheva2011 cite book author Maria Proytcheva title Diagnostic Pediatric Hematopathology url http books.google.com books?id 8s8stgvB1kUC&pg PA544 accessdate 15 May 2011 date 14 March 2011 publisher Cambridge University Press isbn 9780521881609 pages 544 ref Prognosis It can evolve into lymphoma . ref name pmid16638423 cite journal author Dalle S, Balme B, Thomas L title Lym ... more details
Infobox Company name American Pathology Partners, Inc. logo type Private company Private genre foundation 2008 founder Thanasis Papaioanu, Edward Dooling, Martin Rash, Robert Yeager location city Nashville, Tennessee Nashville , Tennessee , United States U.S. location country location locations area served key people Robert Yeager small Chairman small br Sami Abbasi small Chief executive officer CEO small br Robert Mignatti small Chief operating officer COO small br Edward Dooling small CGO small br Thanasis Papaioanu small Chief information officer CIO CDO small br John Starling small Chief financial officer CFO small br Lee Dilworth small General Counsel small industry Healthcare industry Healthcare products services Clinical laboratory revenue operating income net income assets equity owner num employees 200 parent divisions subsid homepage http www.ap2.com www.ap2.com footnotes intl American Pathology Partners, Inc. otherwise referred to as APP or AP2 is a privately held medical laboratory company ref cite web title American Pathology Partners, Inc. Private Company Information url http investing.businessweek.com research stocks private snapshot.asp?privcapId 52010249 publisher Bloomberg BusinessWeek ref headquartered in Nashville, Tennessee Nashville , Tennessee . The company operates a nationwide network of pathology laboratories focused on local and regional healthcare. APP serves physician offices, hospitals, and surgery centers with sub specialized anatomic and molecular pathology services including surgical pathology , cytopathology , dermatopathology , hematopathology , urologic pathology, gastrointestinal and liver pathology, renal pathology , and pediatric and perinatal pathology. APP currently operates three laboratory facilities including Denver, Colorado Wilson, North Carolina and West Palm Beach, Florida doing business as UniPath, Eastern Carolina Pathology, and Palm Beach Pathology in their respective geographies. History In February 2008, APP was f ... more details
PBB geneid 3508 DNA binding protein SMUBP 2 is a protein that in humans is encoded by the IGHMBP2 gene . ref name pmid8349627 cite journal author Fukita Y, Mizuta TR, Shirozu M, Ozawa K, Shimizu A, Honjo T title The human S mu bp 2, a DNA binding protein specific to the single stranded guanine rich sequence related to the immunoglobulin mu chain switch region journal J Biol Chem volume 268 issue 23 pages 17463 70 year 1993 month Sep pmid 8349627 pmc doi ref ref name entrez cite web title Entrez Gene IGHMBP2 immunoglobulin mu binding protein 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3508 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Giannini A, Pinto AM, Rossetti G, et al. title Respiratory failure in infants due to spinal muscular atrophy with respiratory distress type 1. journal Intensive care medicine volume 32 issue 11 pages 1851 5 year 2007 pmid 16964485 doi 10.1007 s00134 006 0346 8 cite journal author Kerr D, Khalili K title A recombinant cDNA derived from human brain encodes a DNA binding protein that stimulates transcription of the human neurotropic virus JCV. journal J. Biol. Chem. volume 266 issue 24 pages 15876 81 year 1991 pmid 1714899 doi cite journal author Mizuta TR, Fukita Y, Miyoshi T, et al. title Isolation of cDNA encoding a binding protein specific to 5 phosphorylated single stranded DNA with G rich sequences journal Nucleic Acids Res. volume 21 issue 8 pages 1761 6 year 1993 pmid 8493094 doi 10.1093 nar 21.8.1761 pmc 309412 cite journal author Gulley ML, Zhang Q, Gascoyne RD, et al. title Translocations of 11q13 in mantle cell lymphoma fail to disrupt the S mu bp 2 gene journal Hematopathology and molecular hematology volume 11 issue 1 pages 1 11 year 1998 pmid 9439975 doi cite journal a ... more details
Encyclopedia
top
