Histiocyte can also simply refer to a cell from monocyte origin outside the blood system, such as in a tissue ... Histiocytoses describe neoplasias where the proliferative cell is the histiocyte. The most common histiocyte disorders are Langerhans cell histiocytosis and haemophagocytic lymphohistiocytosis . ref name pmid9039734 cite journal author Webb DK title Histiocyte disorders journal Br. Med. Bull ... Category Cell biology Category Mononuclear phagocytes cs Histiocyt de Histiozyt es Histiocito fr Histiocyte ... more details
Image Hemophagocytic syndrome cropped very high mag.jpg thumb right Micrograph showing hemophagocytosis in the spleen . H&E stain . Hemophagocytosis is phagocytosis by histiocyte s of erythrocyte s, leukocyte s, platelet s, and their precursors ref cite web url http www.medscape.com viewarticle 414792 title Hemophagocytic Syndromes and Infection format work accessdate ref in bone marrow and other tissues. It is part of the presentation of hemophagocytic lymphohistiocytosis . References reflist Category Pathology medicine stub ... more details
Infobox Disease Name Histiocytoma Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D051642 A histiocytoma is a Tumor tumour consisting of histiocyte s. ref DorlandsDict nine 000953559 histiocytoma ref Histiocytes are Cells biology cell s that are a part of the mononuclear phagocytic system , a part of the body s immune system that consists of phagocytic cells, which are responsible for engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists . Types include benign fibrous histiocytoma malignant fibrous histiocytoma histiocytoma dog References Reflist Soft tissue tumors and sarcomas Category Connective soft tissue tumors and sarcomas Category Dermal and subcutaneous growths Dermal growth stub ... more details
The mononuclear phagocyte system is a part of the immune system that consists of the phagocytosis phagocytic cells ref MeshName Mononuclear Phagocyte System ref located in reticular connective tissue . The cells are primarily monocyte s and macrophage s, and they accumulate in lymph node s and the spleen . The Kupffer cell s of the liver and tissue histiocyte s are also part of the MPS. Reticuloendothelial system is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophage s. ref name Singh2006 cite book author Inderbir Singh title Textbook of human histology url http books.google.com books?id Ej22iANgNkoC&pg PA90 accessdate 12 November 2010 year 2006 publisher Jaypee Brothers Publishers isbn 9788180618093 pages 90 ref The spleen is the largest unit of the mononuclear phagocyte system. The monocyte is formed in the bone marrow and transported by the blood it migrates into the tissues, where it transforms into a histiocyte or a macrophage. Macrophages are diffusely scattered in the connective tissue and in liver Kupffer cells , spleen and lymph nodes sinus histiocytes , lungs alveolar macrophages , and central nervous system microglia . The half life of blood monocytes is about 1 day, whereas the life span of tissue macrophages is several months or years. The mononuclear phagocyte system is part of both humoral and cell mediated immunity. The mononuclear phagocyte system has an important role in defense against microorganisms, including mycobacteria, fungi, bacteria, protozoa, and viruses. Macrophages remove senescent erythrocytes, leukocytes, and megakaryocytes by phagocytosis and digestion. Functions Formation of new red blood cells RBCs and white blood cells WBCs . Destruction of old RBCs and WBCs Formation of antibody. Formation of plasma proteins. Formation of bile pigments. References reflist External links GPnotebook 550502460 GeorgiaImmunology 1 reticulo Myeloid inn ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD9 ICDO M9755 3 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D054747 Histiocytic sarcoma is a tumor derived from histiocyte s. ref name pmid18239326 cite journal author Yoshida C, Takeuchi M title Histiocytic sarcoma identification of its histiocytic origin using immunohistochemistry journal Intern. Med. volume 47 issue 3 pages 165 9 year 2008 pmid 18239326 doi 10.2169 internalmedicine.47.0386 url http joi.jlc.jst.go.jp JST.JSTAGE internalmedicine 47.0386?from PubMed format dead link date May 2010 ref The tumor is often positive for CD163 ref name pmid15696128 cite journal author Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS title Histiocytic sarcoma a study of five cases including the histiocyte marker CD163 journal Mod. Pathol. volume 18 issue 5 pages 693 704 year 2005 month May pmid 15696128 doi 10.1038 modpathol.3800346 ref and can appear in the thyroid . ref name pmid18386009 cite journal author De Vos FY, Gerding MN, Arends JW, Wegman JJ title Histiocytic sarcoma localised in the thyroid a case report journal Ann. Hematol. volume 87 issue 8 pages 681 2 year 2008 month August pmid 18386009 pmc 2441588 doi 10.1007 s00277 008 0473 0 ref References reflist Category Sarcoma neoplasm stub Histiocytosis Soft tissue tumors and sarcomas ... more details
Infobox Anatomy Name PAGENAME Latin medulla nodi lymphoidei GraySubject GrayPage Image Schematic of lymph node showing lymph sinuses.png Caption Schematic of lymph node showing lymph sinuses Image2 Caption2 Precursor System Artery Vein Nerve Lymph MeshName MeshNumber The medulla of lymph node , or medullary sinus , is the central portion of the lymph node . ref name urlDefinition medulla of lymph node from Online Medical Dictionary cite web url http cancerweb.ncl.ac.uk cgi bin omd?medulla of lymph node title Definition medulla of lymph node from Online Medical Dictionary format work accessdate 2008 10 19 ref There are two named structures in the medulla The medullary cords are cords of lymphatic tissue, and include plasma cell s, macrophages , and B cell s The medullary sinuses or sinusoids are vessel like spaces separating the medullary cords. The Lymph flows into the medullary sinuses from cortical sinuses, and into efferent lymphatic vessels . Medullary sinuses contain histiocyte s immobile macrophages and reticular cell s. See also Medulla disambiguation Medulla References Reflist External links BUHistology 07101loa lymphatic stub Category Lymphatic organ anatomy Lymphatic system ... more details
Infobox disease Name Nonossifying fibroma Image NOF 1.jpg Caption X ray of nonossifying fibroma of distal tibia. DiseasesDB ICD10 ICD10 M 89 8 m 86 ICD9 ICD9 733.99 ICDO OMIM MedlinePlus eMedicineSubj article eMedicineTopic 389590 MeshID File MaturenonossifyingfibromaCT.PNG thumb An ossified non ossifying fibroma on CT A nonossifying fibroma also called fibroxanthoma is a fibrous bone lesion that is usually asymptomatic and discovered as an incidental finding on x ray . It is the most common benign bone tumor in children and adolescents. However, it is controversial whether it represents a true neoplasm or rather a developmental disorder of growing bone. Radiographically, the tumor presents as a well marginated radiolucent lesion, with a distinct multilocular appearance. These foci consist of collagen rich connective tissue , fibroblast s, histiocyte s and osteoclast s. They originate from the growth plate , and are located in adjacent parts of the metaphysis and diaphysis of long bones, most often of the legs. No treatment is needed in asymptomatic patients and spontaneous remission with replacement by bone tissue is to be expected. Multiple nonossifying fibromas occur in Jaffe Campanacci syndrome in combination with cafe au lait spot s, mental retardation , hypogonadism , ocular and cardiovascular abnormalities. See also Fibroma Ossifying fibroma References reflist External links Commons category Nonossifying fibroma http www.wheelessonline.com ortho nonossifying fibroma Wheeless Textbook of Orthopaedics Nonossifying Fibroma Osteochondropathy Category Osteopathies disease stub de Nicht ossifizierendes Fibrom ... more details
Infobox disease Name Rosai Dorfman disease Image Rosai Dorfman disease very high mag.jpg Caption Micrograph of a lymph node involved by Rosai Dorfman disease showing emperipolesis . H&E stain . DiseasesDB 31419 ICD10 D76.3 ILDS D76.360 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Rosai Dorfman disease , also known as sinus histiocytosis with massive lymphadenopathy , is a rare disorder of idiopathic unknown etiology that is characterized by abundant histiocyte s in the lymph node s throughout the body. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 747 Presentation Lymphadenopathy of the neck is the most common place of histiocyte accumulation, although accumulation outside of lymph nodes may occur, as well. The most common sites of accumulation outside of the lymph nodes are skin, upper respiratory tract, and the sinuses. ref name pmid2180012 cite journal author Foucar E, Rosai J, Dorfman R title Sinus histiocytosis with massive lymphadenopathy Rosai Dorfman disease review of the entity journal Semin Diagn Pathol volume 7 issue 1 pages 19 73 year 1990 pmid 2180012 doi accessdate 2007 11 05 ref ref cite journal author Walid MS, Grigorian AA title Ethmo spheno intracranial Rosai Dorfman disease journal Indian J Cancer volume 47 issue 1 pages 80 81 year 2010 pmid 20071801 doi 10.4103 0019 509X.58870 ref The symptoms of this disease vary with the site of accumulation similar to other regional tumors. For instance, accumulation in closed spaces such as the cranium can lead to poor outcomes compared to growth in the dermis of an extremity where surgical excision is possible. History This condition has been named after Ronald F. Dorfman and Juan Rosai . An alternative eponym of this condition is known as Destombes Rosai Dorfman syndrome, part of which is named after Pierr ... more details
Refimprove date November 2009 Infobox Disease Name PAGENAME Image Caption DiseasesDB 29254 ICD10 ICD10 I 39 i 30 , ICD10 M 32 1 m 30 ICD9 ICD9 710.0 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 1295 MeshID D008180 Libman Sacks endocarditis is a form of nonbacterial endocarditis that is seen in lupus erythematosus systemic lupus erythematosus . It is one of the most common cardiac manifestations of lupus the most common being pericarditis . ref Libman Sakcs endocarditis, in Mosby s Medical, Nursing &Allied Health Dictionary, Fourth Edition, Mosby YearBook, Inc., 1994, p. 907 ref It was first described by Drs. Emanuel Libman and Benjamin Sacks at Mount Sinai Hospital, New York Mount Sinai Hospital in New York City in 1924. ref Libman E, Sacks B A hitherto undescribed form of valvular and mural endocarditis. Arch Intern Med 1924 33 701 37. ref ref http www.patient.co.uk showdoc 40024946 Patient.co.uk Libman Sacks Endocarditis Retrieved 2008 08 11 ref The association between Libman Sacks endocarditis and antiphospholipid syndrome was first noted in 1985. Presentation The vegetation pathology vegetation s are small and formed from strands of fibrin , neutrophils , lymphocytes , and histiocyte s. The mitral valve is typically affected, and the vegetations occur on the ventricular and atrial surface of the valve. Libman Sacks lesions rarely produce significant valve dysfunction and the lesions only rarely embolize. ref Doherty NE, Siegel RJ Cardiovascular manifestations of systemic lupus erythematosus. Am Heart J, 1985 Dec 110 6 1257 1265 ref Pathology The pathology is the same as nonbacterial thrombotic endocarditis except focal necrosis hematoxylin bodies can be found only in Libman Sacks endocarditis. Citation needed date November 2009 References reflist Heart diseases Systemic connective tissue disorders Category Valvular heart disease Category Systemic connective tissue disorders de Libman Sacks Endokarditis es Endocarditis de Libman Sacks it Sindrome di Lib ... more details
Infobox Disease Name PAGENAME Image Michaelis Gutmann bodies very high mag cropped.jpg Caption Micrograph showing the characteristic finding of malakoplakia Michaelis Gutmann bodies . H&E stain . Width 225 DiseasesDB 29128 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj derm eMedicineTopic 872 MeshID D008287 Malakoplakia is a rare inflammatory condition which makes its presence known as a papule , plaque Disambiguation needed date January 2012 or genital ulcer ulceration that usually affects the genitourinary tract . ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 274 However, it may also be associated with other bodily organs. It was initially described in the early 1900s as soft yellowish plaques found on the mucosa of the urinary bladder . Microscopically it is characterized by the presence of foamy histiocyte s with basophil ic inclusions called Michaelis Gutmann body Michaelis Gutmann bodies . It usually involves gram negative bacteria. ref name ChengBostwick2006 cite book author1 Liang Cheng author2 David G. Bostwick title Essentials of anatomic pathology url http books.google.com books?id B LUwWcqspoC&pg PA1180 accessdate 15 May 2010 year 2006 publisher Springer isbn 9781588294616 pages 1180 ref Causes Malakoplakia is thought to result from the insufficient killing of bacteria by macrophage s. Therefore, the partially digested bacteria accumulate in macrophages and leads to a deposition of iron and calcium . The impairment of bactericide bactericidal activity manifests itself as the formation of an ulcer dermatology ulcer , plaque or papule. Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma , diabetes mellitus , renal transplant ation, or because of long term Pharmacotherapy therapy with systemic corticosteroid s. Treatment Today, antib ... more details
s, and normal histiocyte s form typical LCH lesions that can be found in almost any Organ anatomy ... k.BD72 Home.htm Histiocyte Society An International Community Dedicated to Research and Treatment ... more details
Image Histiocytoma.JPG thumb A histiocytoma on the ear of a dog Image Canine histiocytoma.jpg thumb Canine Cutaneous Histiocytoma on a young boxer dog A histiocytoma in the dog is a benign tumor. It is an abnormal growth in the skin of histiocyte s histiocytosis , a cell that is part of the immune system . A similar disease in humans, Hashimoto Pritzker disease , is also a Langerhans cell histiocytosis . ref cite journal author Marchal T, Saint Andr I, Magnol J, Dezutter Dambuyant C, Schmitt D title Dendritic cells in dogs and cats models of study in human pathology journal Pathol. Biol. volume 43 issue 10 pages 910 20 year 1995 pmid 8786898 ref Dog breeds that may be more at risk for this tumor include Bulldog s, Scottish Terrier s, Greyhound s, Boxer dog Boxer s, and Boston Terrier s. They also rarely occur in goat s and cattle . ref cite web title Tumors with Histiocytic Differentiation work The Merck Veterinary Manual date 2006 url http www.merckvetmanual.com mvm index.jsp?cfile htm bc 72232.htm accessdate 2007 04 29 ref Histiocytic disorders A histiocyte is a differentiated tissue cell that has its origin in the bone marrow . The source for histiocytes is the monocyte macrophage line. Monocytes found in the blood and macrophages found in tissue are responsible for phagocytosis ingestion of foreign material in the body. Langerhans cell s are dendritic cell s found in the skin and function by internalizing antigen s foreign particles and presenting them to T cell s. They arise from monocytes. ref cite journal author Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M title Langerhans cells arise from monocytes in vivo journal Nat. Immunol. volume 7 issue 3 pages 265 73 year 2006 pmid 16444257 doi 10.1038 ni1307 ref Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. They include the following Reactive diseases of Langerhans cells Histiocytomas Cutaneous histiocytosis Systemic his ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 D76.3 ILDS D76.330 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Sea blue histiocytosis is a cutaneous condition that may occur as a familial inherited syndrome or as an acquired secondary or systemic infiltrative process. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 720 Causes It can be associated with the gene Apolipoprotein E APOE . ref name pmid16094309 cite journal author Faivre L, Saugier Veber P, Pais de Barros JP, et al title Variable expressivity of the clinical and biochemical phenotype associated with the apolipoprotein E p.Leu149del mutation journal Eur. J. Hum. Genet. volume 13 issue 11 pages 1186 91 year 2005 month November pmid 16094309 doi 10.1038 sj.ejhg.5201480 ref It can also be acquired. ref name pmid11732877 cite journal author Candoni A, Grimaz S, Doretto P, Fanin R, Falcomer F, Bembi B title Sea blue histiocytosis secondary to Niemann Pick disease type B a case report journal Ann. Hematol. volume 80 issue 10 pages 620 2 year 2001 month October pmid 11732877 doi 10.1007 s002770100354 url http link.springer.de link service journals 00277 bibs 1080010 10800620.htm ref Sea blue histiocyte syndrome is seen in patients receiving fat emulsion as a part of long term parenteral nutrition TPN for intestinal failure. Pathophysiology and presentation The high lipid content in the blood leads to excessive cytoplasm loading of lipids within histiocytes. The subsequent incomplete degradation of these lipids leads to the formation of cytoplasmic lipid pigments. High lipid content may also cause membrane abnormality of the hemopoietic cells which is recognized by macrophages and therefore, increased accumulation within the bone marrow. These lipid laden histiocytes appear blue with May Giemsa ref na ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 C 96 1 c 81 ICD9 ICD9 202.3 ICDO ICDO 9750 3 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D015620 Malignant histiocytosis also known as Histiocytic medullary reticulosis ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 744 is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocyte histiocytic infiltration of the lungs and lymph node s. The liver , spleen , and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition to its importance in veterinary medicine, the condition is also important in human pathology. ref http dermnetnz.org dermal infiltrative malignant histiocytoses.html Malignant histiocytoses. DermNet NZ Bot generated title ref Histiocytic disorders A histiocyte is a differentiated tissue cell that has its origin in the bone marrow . The source for histiocytes is the monocyte macrophage line. Monocytes found in the blood and macrophages found in tissue are responsible for phagocytosis ingestion of foreign material in the body. Langerhans cell s are dendritic cell s found in the skin and function by internalizing antigen s foreign particles and presenting them to T cell s. They arise from monocytes. ref cite journal author Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M title Langerhans cells arise from monocytes in vivo journal Nat. Immunol. volume 7 issue 3 pages 265 73 year 2006 pmid 16444257 doi 10.1038 ni1307 ref Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. They include the following Reactive diseases of Langerhans cells most important feature in immune histochemistry i ... more details
Infobox Disease Name Histiocytosis Image Caption DiseasesDB ICD10 ICD10 C 96 1 c 81 , ICD10 D 76 0 d 70 ICD9 ICD9 202.3 , ICD9 277.89 ICDO OMIM MedlinePlus eMedicineSubj ped eMedicineTopic 1997 MeshID D015614 In medicine , histiocytosis refers to an excessive number of histiocyte s, ref EMedicineDictionary Histiocytosis ref tissue macrophages , and is typically used to refer to a group of rare diseases which share this as a characteristic. Occasionally and confusingly, the term histiocytosis is sometimes used to refer to individual diseases. The histiocytes may attack skin, bone, muscles, and other important organs, including the liver, lung, spleen, and hematopoietic system. The disease is somewhat similar to cancer , and treatment often involves radiation and chemotherapy . According to the Histiocytosis Association of America , 1 in 200,000 children in the United States are born with histiocytosis each year. ref http www.histio.org site c.kiKTL4PQLvF b.1810505 k.F16D Disease Information.htm Disease information at the Histiocytosis Association of America ref HAA also states that most of the people diagnosed with histiocytosis are children under the age of 10. The University of California, San Francisco , states that the disease usually occurs from birth to age 15. ref http www.ucsfhealth.org childrens medical services cancer histio conditions histio signs.html Histiocytosis Signs and Symptoms Bot generated title ref Histiocytosis and malignant histiocytosis are both important in veterinary as well as human pathology. Classification, and relationships to other conditions There are competing systems for classifying histiocytoses. According to the 1999 classification proposed by the World Health Organization , they can be divided into three categories. ref cite journal author Harris N, Jaffe E, Diebold J, Flandrin G, Muller Hermelink H, Vardiman J, Lister T, Bloomfield C title The World Health Organization classification of neoplastic diseases of the hematopoietic an ... more details
Infobox Disease Name Kikuchi disease Image Histiocytic necrotizing lymphadenitis intermed mag.jpg Caption Micrograph of a lymph node with Kikuchi disease showing the characteristic features abundant histiocytes , necrosis without neutrophil s . H&E stain . DiseasesDB blockquote blockquote ICD10 ICD9 ICDO OMIM OMIM mult MedlinePlus eMedicineSubj med eMedicineTopic 3663 eMedicine mult MeshID D020042 Kikuchi s disease , also known as histiocyte histiocytic necrosis necrotizing lymphadenitis ref name pmid15570824 cite journal author Kaushik V, Malik TH, Bishop PW, Jones PH title Histiocytic necrotising lymphadenitis Kikuchi s disease a rare cause of cervical lymphadenopathy journal Surgeon volume 2 issue 3 pages 179 82 year 2004 month June pmid 15570824 doi url ref and Kikuchi Fujimoto disease , ref name pmid16722618 cite journal author Bosch X, Guilabert A title Kikuchi Fujimoto disease journal Orphanet J Rare Dis volume 1 issue pages 18 year 2006 pmid 16722618 pmc 1481509 doi 10.1186 1750 1172 1 18 url http www.ojrd.com content 1 18 ref ref name pmid15272543 cite journal author Bosch X, Guilabert A, Miquel R, Campo E title Enigmatic Kikuchi Fujimoto disease a comprehensive review journal Am. J. Clin. Pathol. volume 122 issue 1 pages 141 52 year 2004 month July pmid 15272543 doi 10.1309 YF08 1L4T KYWV YVPQ url http ajcp.ascpjournals.org cgi pmidlookup?view long&pmid 15272543 ref is a rare, non cancerous enlargement of the lymph node s. It was first described in Japan by Dr Masahiro Kikuchi in 1972 ref Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes. Acta Hematol Jpn 1972 35 379 80. No PMID ref and independently by Y. Fujimoto. Epidemiology Kikuchi s disease is a very rare disease and mainly seen in Japan. Isolated cases are reported in America, Europe and Asia. It is mainly a disease of young adults mean age, 20 30 years , with a slight bias towards females. The cause of this disease is not known although infectious ... more details
Infobox scientist name Nikolay Nikolaevich Anichkov image image size caption birth date 1885 birth place death date 7 December 1964 death place residence Russia citizenship Russia n nationality ethnicity fields Pathology workplaces alma mater Imperial Military Medical Academy, St. Petersburg doctoral advisor academic advisor doctoral students notable students known for Atherosclerosis research author abbrev bot author abbrev zoo influences influenced awards religion signature filename only footnotes Nikolay Nikolaevich Anichkov lang ru , often spelled Anitschkow in German literature 1885 1964 was a prominent pathologist of Russia n heritage. Anichkov first described the specialized myocardium myocardial cells Anitschkow cell , cardiac histiocyte and discovered the significance and role of cholesterol in atherosclerosis pathogenesis. In 1958, in an editorial in Annals of Internal Medicine , William Dock compared the significance of the classic work of Anichkov to that of the discovery of the tubercle bacillus by Robert Koch . American biochemist D. Steinberg wrote If the full significance of his findings had been appreciated at the time, we might have saved more than 30 years in the long struggle to settle the cholesterol controversy and Anitschkow might have won a Nobel Prize . ref J. Lipid Res., 2004, Vol. 45, p. 1583 93. ref Anichkov elaborated on the doctrines of reticuloendothelial system and autogenic infection s. Early life and training His father, Nikolay M. Anichkov 1844 1916 , was a representative of ancient Russian nobility and held the position of Vice Minister of Education of the Russian Empire . His mother, L. I. Vasiliyeva 1859 1924 , was the daughter of a priest that was founder of the Alexander Nevsky Orthodox church in Rue Daru, Paris . In 1903, Anichkov entered the Imperial Military Medical Academy in St. Petersburg . There, he became a pupil of prominent Russian histology histologist Alexander A. Maximow 1874 1928 and ... more details
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